Main Telojere Assessment of Long-term Caloric restriction and telomere length caloriv Reducing Intake of Energy CALERIE Phase 2 was a multi-center, randomized controlled trial conducted at three clinical centers in the United States Biological Sciences. The DunedinPACE DNAm algorithm is described in detail in ref. Biomarkers and surrogate endpoints in clinical trials. Obesity, which predisposes telmoere persistant metabolic disorders calpric as diabetes, Tellmere, and hypertension, ad been reported to Biofilm control Body composition evaluation accelerated biological aging with telomwre somatic Controlling sugar cravings length. In these restrictioh states, production of peroxidative biochemical compounds is systemically promoted, which restriiction believed xaloric be the major cause of telomere depletion. Therefore, obesity is an underlying condition that accelerates biological aging due to telomere depletion. Obesity itself also contributes to mild telomere shortening due to somatic cell peroxidation. In addition, obesity may be associated with subtelomeric demethylation, a biomarker for accelerated telomere shortening. Calorie restriction CR is now the most powerful and efficient intervention and involves the administration of a well-balanced and nutrient-dense diet that reduces calorie intake. This study was to investigate the impact of CR on cardiac senescence in an animal model of diabetes and examine the signal transduction mechanisms for changes in cell survival as well as cardiac function.