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Criteria for Weight Loss Medication Prescriptions Determining whether someone is a candidate for weight loss medications begins with BMI.

Currently Available Weight Loss Medications Some weight loss medications have been on the market for many years, and new ones emerge frequently. Commonly prescribed weight loss medications include: Semaglutide Wegovy, Ozempic Wegovy is a brand name for semaglutide, a GLP-1 receptor agonist.

Ozempic is the same medication but is approved to treat type 2 diabetes. Tirzepatide Zepbound, Mounjaro Tirzepatide was previously approved to treat type 2 diabetes as Mounjaro.

Liraglutide Saxenda Liraglutide is a daily injectable medication that acts on hormones from the gut that send signals to the brain to make the patient feel full quicker and decrease hunger signals. Phentermine Adipex, Suprenza Phentermine is the oldest and most widely used weight loss medication.

Phentermine-topiramate Qsymia Topiramate can be combined with phentermine to decrease appetite and cravings. Naltrexone-bupropion Contrave Naltrexone-bupropion combines an opioid receptor antagonist with an antidepressant to affect the pleasure-reward areas of the brain and thereby decrease cravings and appetite.

Setmelanotide Imcivree Setmelanotide is a melanocortin-4 receptor agonist indicated for chronic weight management in adult and pediatric patients 6 years of age and older with obesity due to one of several specific rare genetic disorders.

Orlistat Xenical and Alli Orlistat is a lipase inhibitor that comes in a capsule and works by blocking the enzyme that breaks down fats consumed through food. Hydrogel Plenity A medical device rather than a medication, Plenity was FDA-cleared in for people with a BMI of 24 to Upcoming Weight Loss Medications With fervent consumer demand for weight loss medications, combined with rising obesity rates, more medications are bound for the market in the coming years.

Frequently Asked Questions About Weight Loss Medications How effective are weight loss medications? What is the strongest weight loss prescription medication?

They listed four first-line options: Semaglutide Liraglutide Phentermine-topiramate extended-release ER Naltrexone-bupropion extended-release ER They also recommended phentermine and diethylpropion.

How do weight loss medications work? Are there medications that can cause weight gain? Some beta-blockers and calcium channel blockers Anti-diabetes medications such as insulins, sulfonylureas, thiazolidinediones, and meglitinides Hormone therapies such as glucocorticoids and injectable progestins Anti-seizure medications, including carbamazepine, gabapentin, valproate, and pregabalin A wide variety of different antidepressants Some mood stabilizers Migraine medications such as amitriptyline and paroxetine Some antipsychotics Chemotherapeutic and anti-inflammatory agents How should weight loss medications be used in conjunction with other forms of treatment?

How long do weight-loss medications need to be taken? How have options in weight loss medications changed in recent years? How do the different categories of weight loss medications compare in terms of cost?

How do they affect weight regain? What are the differences between OTC and prescription weight loss medications? What is the connection between antidepressant medication and weight loss?

Which weight loss medications are known for suppressing appetite? Dzay, Omar, et al. Online searches for SGLT-2 inhibitors and GLP-1 receptor agonists correlate with prescription rates in the United States: An infodemiological study. Frontiers in Cardiovascular Medicine.

Food and Drug Administration. FDA Approves New Drug Treatment for Chronic Weight Management, First Since June 4, Obesity Algorithm. Obesity Medicine Association Park, Alice. More Weight Loss Drugs Are Coming, and They Could Be Even More Effective. Time, June 26, Cairns, Elizabeth.

Amgen tries something new in obesity. Evaluate Vantage, December 5, Seaborg, Eric. Calling the Shot: Could a Hormonal Approach Be a Key to Treating Obesity? Endocrine News, October Dagam Jeong, Ronny Priefer. Anti-obesity weight loss medications: Short-term and long-term use.

Life Sciences, Volume , , Ghusn, Wissam, MD, et al. Weight Loss Outcomes Associated With Semaglutide Treatment for Patients With Overweight or Obesity.

JAMA Network Open. Wilding, John P. Once-Weekly Semaglutide in Adults with Overweight or Obesity. The New England Journal of Medicine, March 18, Haelle, Tara. AGA Releases Guidelines on Anti-Obesity Medications for Weight Management. Medscape, October 21, Rasmussen, Louise and Michael Erman.

Novo Nordisk, Pfizer weight-loss pills work as well as shots. Reuters, May 22, NIH, National Institute of Diabetes and Digestive and Kidney Diseases. Neuman, Tricia and Juliette Cubanski, What Could New Anti-Obesity Drugs Mean for Medicare?

Kaiser Family Foundation, May 18, Though it's considered "fairly safe," there's no evidence that it actually helps with weight loss, and excessive use has been linked to liver problems.

Other diet pills may contain chitosan, from the shells of crabs, lobsters, and shrimp. In theory, it's supposed to bind fat in your digestive tract so your body can't absorb it. In reality, according to the NIH, the amount of fat it binds is probably not enough to help you lose a significant amount of weight.

The most common ingredients are stimulants like caffeine, yerba mate, bitter orange, or guarana. When it comes to the data on these ingredients, there's not a lot to suggest they help in any way with weight loss, said Katherine Zeratsky , a registered dietitian at the Mayo Clinic.

For example, a study found that rats given caffeine burned more calories than rats doing the same amount of exercise without a stimulant. But there is no evidence that the effect carries over to humans.

Theoretically, all these ingredients should help with weight loss, but it's extremely difficult to figure out if they work, Zeratsky said. That's because most diet pills are made up of multiple ingredients and the directions suggest you take them while having a diet that's restrictive in calories.

So it's hard to tell whether you lost weight because of the product or because you simply ate fewer calories. No matter what diet pill ingredient or program you're considering, it's critical that you talk to your pharmacist first, Zeratsky said, especially if you take other medications.

Though many of the ingredients are considered safe, they can have toxic effects at high doses. And it's possible that they could interfere with your other medications. Your pharmacist can walk you through a cryptic ingredient list and point out any red flags. Close icon Two crossed lines that form an 'X'.

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