Polyphenols and stress reduction -
Their use in disease management should also consider interacting with pharmaceuticals Santini and Novellino, A nutraceutical should be understood, according to recent studies, as a compound or combination of compounds used to prevent or reduce the risk of disease.
The nutraceuticals interact with human microbiota and affect the physiological balance of the body. This declines with age and the inflammatory proliferation which becomes more acute in the presence of oxidative stress. These critical points determine a decreased bioavailability, and finally dysbiosis.
Microbiological modulation of the microbiota and the metabolomic response depend on the capacity to colonize in vivo , which is a limiting factor for the in vitro study. Many studies have been conducted in static systems, and the dynamic response similar to that of the in vivo is assumed to be based on the identification of certain biomarkers e.
The response is determined by a great number of factors, both exogenous and endogenous. The limiting potential arises from the low number of studies using target groups with a microbiota pattern which retains certain characteristics e. In conclusion, drug administration like those of antibiotics or anti-inflammatory drugs, induces oxidative stress through the dynamics of a human-microbiota pattern.
Individual variability reveals a specific response to the microbiota—drug interaction. When classical medication is combined with the nutraceuticals, it reduces the inflammatory pressure and preserves the effect of the microbial plasticity.
Therefore, intervention against dysbiosis becomes the top priority for optimizing the anti-inflammatory response to the growing pressure of oxidative stress.
Nutraceuticals will be a way of promoting human wellbeing in the future, but the degree of valorisation will depend on the understanding of factors that regulate different physiological processes. The use of products compounds as part of a personalized treatment will be an essential point in increasing the quality of life Zmora et al.
This study is supported by the University of Agronomic Sciences and Veterinary Medicine. The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Many thanks to my wife Albertina Vamanu for her effort, critical comments, and partial English editing.
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They are found in foods such as onions, scallions, grapes, and many others. Catechins are part of the flavonoid family and are abundant in green tea, which has several known health benefits discussed below. The amount and type of polyphenolic compounds in foods depend on their origin, ripeness, and how they were farmed, transported, stored, and prepared.
The antioxidant potential of foods can quickly become compromised. Research indicates that organic agriculture particularly fruits produces slightly higher polyphenol content and antioxidant capacity [3].
Juicing may also be one way to improve the intake of polyphenols, but might be best alongside a high-fiber meal that also has dietary fat. While supplements are indicated in some cases, the ideal situation would be to consume polyphenols in their natural state i.
Given what we now know about the role of gut microbiota in human health, the case for emphasizing real food is gaining traction. A diet comprised of ultra-processed and packaged foods is generally low in polyphenols, which may explain why individuals with low-quality diets generally have worse mental health, and why the transition to a whole-food plant-forward diet can improve mood.
Instead of focusing on cutting out convenience foods, focus on adding anti-inflammatory foods! Polyphenols have been proposed as adjunctive treatments in psychiatric and neurodegenerative disorders, and trials are underway [5]. Animal studies have shown that phenolic extracts from parsley produce potent anxiolytic and antidepressant-like effects [6].
More funding is needed to advance this field forward, but recent strides are being made with respect to depression. Epigallocatechin gallate EGCG is an abundant catechin polyphenol in green tea and has been studied for its neuroprotective effects [7]. The green tea amino acid L-theanine has also been shown to reduce stress and anxiety in people exposed to stressful conditions [8].
Multiple compounds in plant foods work synergistically to confer benefits. For this reason, isolating nutraceuticals and consuming them in the supplemental form will never outperform real food but will be the only way to isolate effects through controlled trials.
From clinical experience, we have observed that individuals with lower polyphenolic intakes display higher tendencies for stress eating comfort food. These compounds work at the cellular level and are also involved in microbial processes that lead to the production of metabolites that interact with brain health, as well as reduce inflammation.
Wise Mind Nutrition can personalize a program for you to boost your mood and walk you through the steps on how to include more polyphenol food groups into your daily diet.
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Food for oxidative stress relief: Polyphenols. Cite Share. Oxidative stress has been implicated in Break the habit of mindless eating pathologies of many metabolic, inflammatory, cardiovascular, Polypheno,s neurodegenerative Polyphenolw leading to Polyphenols and stress reduction and Plant-based supplement products. While Polypuenols mechanism remains unclear, overwhelming evidence point to uncontrolled formation of highly reactive oxygen species ROS and nitrogen species RNSand decrease production and availability of endogenous antioxidants or both. These changes cause cellular and tissue damages associated with oxidative stress-related diseases. Over the years, pharmacological remedies using antioxidant therapy have been applied to correct the triggers of these diseases, albeit with considerable risk and side effects. Current interest in the old paradigm of food as medicine is increasingly becoming mainstream. Pablo TateMariela Claudia Protein intake for hormonal balanceMelisa Daniela Marquioni RamellaAngela Redction Suburo; Polyphenols in the prevention of oxidative stress-induced damage Polyphenops ARPE Online workout challenges. Purpose : Sress outer retina is subjected reductionn a highly Polyphenols and stress reduction and cell-damaging milieu. Under healthy conditions, however, oxidative damage reducction buffered by a large array of defensive mechanisms. By contrast, in age-related macular degeneration AMDthe appearance of oxidative changes suggests that environmental and genetical alterations in retinal protection mechanisms would allow the destruction of the retinal pigment epithelium RPE and photoreceptors. Since enhancement of cellular antioxidant mechanisms could be beneficial for AMD, we have tested caffeic CAF and chlorogenic CHL acids on H 2 O 2 -induced damage of RPE-derived ARPE cells. Methods : ARPE cell damage was induced by H 2 O 2 µM for 90 minutes. Polyphenols were applied before damage 70 µM CAF or µM CHL for 2 hours.
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