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The Chinese even in their old age eat it and run to the bathroom, all because they consume... An antioxidant supplement studied for its effects Pycnogenol and cholesterol inflammation and nad prevention. Pycnogenol is an antioxidant Controlling sugar levels from French maritime pine Pinus maritima Pycnoggenol bark. It's been studied for conditions as varied as heart disease and attention deficit hyperactivity disorder ADHD. However, data on its efficacy and safety are limited. This article discusses pycnogenol's evidence-based benefits and risks, including drug interactions and precautions to consider before adding this supplement to your medicine cabinet.Pycnogenol and cholesterol -
Further to lowering elevated blood pressure, kidney-protective measures represent an important target in advanced hypertension management and treatment. In patients with previously untreated hypertension and early signs of kidney damage, as judged by elevated urinary albumin levels, Pycnogenol ® was taken as an adjunct to medication with ACE-inhibitor Ramipril over a period of six months [Cesarone et al.
The major improvement of kidney function with Pycnogenol ® was shown to coincide with better kidney cortical blood flow velocity which increased significantly compared to the group taking Ramipril only.
The cardiovascular risk factor CRP decreased significantly with Pycnogenol ® from initial 2. One of the major characteristic of metabolic syndrome is hypertension. Pycnogenol ® taken by patients affected by metabolic syndrome criteria, such as obesity, hypertension, elevated blood sugar and high cholesterol for six months showed significant improvement of most parameters [Stuard et al.
Compared to a control group medicated with ACE-inhibitor Lisinopril only, patients taking Pycnogenol ® in addition to Lisinopril achieved a significantly healthier blood pressure, HbA1c level, body mass index and also better total blood cholesterol and HDL values.
Kidney function was significantly improved as judged from lowered 24 hour urinary albumin as well as better kidney cortical blood flow velocity. In a double-blind, placebo controlled study with type II diabetic patients medicated with ACE inhibitor Lisinopril and hypoglycaemic medication, Pycnogenol ® significantly lowered blood pressure and half of the patients were able to lower their individual hypotensive medication dosage [Zibadi et al.
Improved endothelial function was identified by significantly lowered levels of vaso-constrictory endothelin-1 in serum of patients. Urinary albumin values were significantly lowered with Pycnogenol , while only marginal effects were found for placebo.
Pycnogenol ® was shown to significantly improve blood sugar as compared to the placebo group. Elevated blood glucose represents another serious threat to cardiovascular health and Pycnogenol ® was shown effective for normalising blood glucose in several clinical trials. This effect was found to result from inhibition of duodenal α -glucosidase.
For more information on Pycnogenol ® for blood glucose lowering, diabetes and metabolic syndrome please consult the Diabetes section of this site. In summary, Pycnogenol ® is helpful on its own for normalising borderline hypertension and also beneficial when taken as an adjunct to standard hypotensive medication.
Whereas hypertension, atherosclerosis and diabetes contribute to progressive damage of blood vessel walls, the acute problems occurring during heart attack and stroke result from aggregation of blood platelets. An impaired endothelial function and decreased availability of nitric oxide leads to an increased platelet activity.
Situations involving impaired endothelial function, hypercoagulability and altered haemodynamics such as stasis promote the development of platelet aggregates and thrombosis. The resulting thrombus may cause clogging of blood vessels embolism and subsequently interrupt the blood flow to certain areas of the body.
This may be lifethreatening when a blood clot obstructs arteries of the lung, disabling vital oxygen uptake pulmonary embolism. When arteries supporting heart muscle coronaries are affected, oxygen supply is interrupted causing myocardial infarction. By virtue of increasing the production of endothelial nitric oxide, Pycnogenol® significantly lowers the activity of blood platelets.
Nitric oxide represents the natural body-own messenger molecule for releasing elevated thrombocyte activity. Pycnogenol® was shown to dose-dependently lower platelet activity in individuals typically presenting with increased platelet aggregation: cigarette smokers.
Blood was drawn before and 2 hours after administration of a single Pycnogenol® dose. The results clearly showed a dose-dependent reduction of platelet activity. Already the lowest dose of 25 mg Pycnogenol® noticeably lowered the blood platelet activity [Pütter et al.
Further research revealed that Pycnogenol® inhibits release of thromboxane from platelets of cigarette smokers to levels of healthy non-smokers [Araghi-Niknam et al. Pycnogenol® was shown to be as effective for controlling platelet activity as aspirin in these experiments [Pütter et al.
Moreover, Pycnogenol® was found not to increase bleeding time, an effect which is well known in case of aspirin, which significantly prolongs bleeding.
The use of Pycnogenol® for regulation of platelet function is patented US 5,, Pycnogenol® was tested in a group of individuals at risk for developing thrombosis [Belcaro et al.
In a study published in the March Diabetes Care, Pycnogenol was shown to lower blood sugar levels and not affect insulin levels. Additionally, Pycnogenol has been shown to reduce fasting and postprandial serum glucose levels and glycosylated hemoglobin in patients with type II diabetes.
And, earlier studies with more than 1, diabetes patients, showed that Pycnogenol has the ability to seal leaky capillaries in the eye. This capability stops the progression of vision loss in patients suffering from diabetic retinopathy, a diabetes-induced eye disease that ultimately leads to blindness.
Pycnogenol is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits.
The extract has been widely studied for the past 35 years and has more than published studies and review articles ensuring safety and efficacy as an ingredient. Today, Pycnogenol is available in more than dietary supplements, multi-vitamins and health products worldwide.
For more information, visit www. Natural Health Science Inc. NHS , based in Hoboken, New Jersey, is the North American distributor for Pycnogenol pic-noj-en-all brand French maritime pine bark extract on behalf of Horphag Research.
Pycnogenol is a registered trademark of Horphag Research Ltd. Vinciguerra G, Belcaro G, Bonanni E, et al. Evaluation of the effects of supplementation with Pycnogenol® on fitness in normal subjects with the Army Physical Fitness Test and in performances of athletes in the minute triathlon.
J Sports Med Phys Fitness. Malekahmadi M, Shadnoush M, Islam SMS, et al. The effect of French maritime pine bark extract supplementation on inflammation, nutritional and clinical status in critically ill patients with traumatic brain injury: A randomized controlled trial.
Lima PB, Dias JAF, Esposito ACC, et al. French maritime pine bark extract pycnogenol in association with triple combination cream for the treatment of facial melasma in women: A double-blind, randomized, placebo-controlled trial. J Eur Acad Dermatol Venereol.
Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for treating osteoarthritis: A systematic review and meta-analysis. Br J Sports Med. Smetanka A, Stara V, Farsky I, et al. Pycnogenol supplementation as an adjunct treatment for antidepressant-induced sexual dysfunction. Physiol Int.
Belcaro G, Dugall M, Luzzi R, et al. Postpartum varicose veins: Supplementation with pycnogenol or elastic compression-A month follow-up.
Int J Angiol. Toledo RR, Santos MERC, Schnaider TB. Effect of Pycnogenol on the Healing of Venous Ulcers. Ann Vasc Surg. de Waard AM, Hollander M, Korevaar JC, et al. Selective prevention of cardiometabolic diseases: activities and attitudes of general practitioners across Europe.
Eur J Public Health. Rašković A, Bukumirović N, Paut Kusturica M, et al. Hepatoprotective and antioxidant potential of Pycnogenol® in acetaminophen-induced hepatotoxicity in rats. Cai C, Zeng B, Lin L, et al. An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo-controlled, double blind intervention study.
Health Sci Rep. Published Jan 6. Grether-Beck S, Marini A, Jaenicke T, et al. French maritime pine bark extract pycnogenol® effects on human skin: Clinical and molecular evidence. Trebaticky B, Muchova J, Ziaran S, et al.
Natural polyphenols improve erectile function and lipid profile in patients suffering from erectile dysfunction.
Bratisl Lek Listy. By Megan Nunn, PharmD Megan Nunn, PharmD, is a community pharmacist in Tennessee with over twelve years of experience in medication counseling and immunization.
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What Is It? Frequently Asked Questions. Pycnogenol Supplement Facts Active Ingredient s : Flavonoids like proanthocyanidins, polyphenols caffeic acid, ferulic acid, catechin, epicatechin, and taxifolin Alternate Names : French maritime pine bark Pinus pinaster , picnogenol, Pinus maritima extract Legal Status : Over-the-counter OTC dietary supplement United States Suggested Dose : May vary based on condition and dosage form.
Doses used in clinical trials range from 50 to milligrams mg daily. Safety Considerations : Pycnogenol is not recommended during the first trimester of pregnancy or during breastfeeding. It's also not recommended for children less than 6 years old.
Pycnogenol may interact with prescription medications, herbs, and supplements for cancer, blood pressure, diabetes, and inflammation.
Frequently Asked Questions What is pycnogenol used for?
qnd Pycnogenol xnd view more. A Pgcnogenol study published in the May volume Pomegranate Mocktails, issue 25 edition of cholwsterol journal of Pycnogenol and cholesterol Research shows Pycnogenol pic-noj-en-all aand, an antioxidant plant Cholesterop from Pycnogenol and cholesterol bark of the French maritime pine tree, reduces blood sugar in type II diabetes patients, allows people to lower their antihypertensive medication and improves cardiovascular disease CVD risk factors. The study, conducted at the University of Arizona, Tucson, indicates Pycnogenol may serve as a potent adjunct to prescription medications for the 20 million people in the Unites States living with diabetes. Ronald Watson, a lead researcher of the study. But what really makes the study results compelling is Pycnogenol simultaneously lowered blood glucose, LDL cholesterol and blood pressure in patients.
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