Sarna S ,. Ahotupa M. Affiliations 1. Department of Physiology, University of Turku, Finland. Authors Vasankari T 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook.

Abstract Background We studied the effects of supplementation of vitamin C and carbohydrate on acute exercise-induced lipid peroxidation. Methods Experimental design two randomized controlled trials. Participants 17 endurance athletes. Interventions in study I, nine athletes repeated twice a In study II, eight athletes repeated twice a km maximal run and ingested in randomly either g carbohydrate or placebo.

Venous blood samples were taken before the exercise, immediately after the exercise, and after a recovery period of 90 min study I or min study II.

Measure serum diene conjugation, lipid peroxidation. Results In study I, there was no difference in serum diene conjugation between the trials during exercise pre- vs post-exercise. In study II, there was no difference between the carbohydrate and placebo trials.

Conclusions Vitamin C and carbohydrate do not prevent exercise-induced increase in oxidative stress, but vitamin C, being a potent aqueous antioxidant, seems to decrease the levels of diene conjugation during recovery after exercise.

The clinical significance of this phenomenon needs further evaluation. Vitamin C and glutathione supplementation: a review of their additive effects on exercise performance.

Lee E , Park HY , Kim SW , Kim J , Lim K Phys Act Nutr , 27 3 , 30 Sep Cited by: 0 articles PMID: PMCID: PMC Review Articles in the Open Access Subset are available under a Creative Commons license.

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Bjelakovic G , Nikolova D , Gluud LL , Simonetti RG , Gluud C Cochrane Database Syst Rev , 3 :CD, 14 Mar Cited by: articles PMID: PMCID: PMC Review Free full text in Europe PMC.

Effect of a special carbohydrate-protein cake on oxidative stress markers after exhaustive cycling in humans. Kerasioti E , Kiskini A , Veskoukis A , Jamurtas A , Tsitsimpikou C , Tsatsakis AM , Koutedakis Y , Stagos D , Kouretas D , Karathanos V Food Chem Toxicol , 50 8 , 17 Apr Cited by: 21 articles PMID: Antioxidant supplementation during exercise training: beneficial or detrimental?

Peternelj TT , Coombes JS Sports Med , 41 12 , 01 Dec Cited by: articles PMID: Review. Carbohydrate administration and exercise performance: what are the potential mechanisms involved? Karelis AD , Smith JW , Passe DH , Péronnet F Sports Med , 40 9 , 01 Sep Cited by: 37 articles PMID: Review.

Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Increased serum and low-density-lipoprotein antioxidant potential after antioxidant supplementation in endurance athletes.

Vasankari TJ , Kujala UM , Vasankari TM , Vuorimaa T , Ahotupa M Am J Clin Nutr , 65 4 , 01 Apr Cited by: 29 articles PMID: Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans.

Morrison D , Hughes J , Della Gatta PA , Mason S , Lamon S , Russell AP , Wadley GD Free Radic Biol Med , , 19 Oct Cited by: 86 articles PMID: Carbohydrate ingestion during prolonged running exercise results in an increase of serum cortisol and decrease of gonadotrophins.

Vasankari TJ , Kujala UM , Viljanen TT , Huhtaniemi IT Acta Physiol Scand , 3 , 01 Mar Cited by: 1 article PMID: Influence of an antioxidant vitamin-enriched drink on pre- and post-exercise lymphocyte antioxidant system.

Sureda A , Tauler P , Aguiló A , Cases N , Llompart I , Tur JA , Pons A Ann Nutr Metab , 52 3 , 19 Jun Cited by: 13 articles PMID: Vitamin C: effects of exercise and requirements with training.

Peake JM Int J Sport Nutr Exerc Metab , 13 2 , 01 Jun Cited by: 35 articles PMID: Review. Claim to ORCID Get citation. Follow us News blog Technical blog Twitter YouTube.

About About Europe PMC. Become a funder. Tools Tools overview. ORCID article claiming. Journal list. Grant finder. External links service. Annotations submission service. Developers Developer resources. Articles RESTful API. Grants RESTful API. API case studies.

SOAP web service. Annotations API. OAI service. Bulk downloads. Developers Forum. Free Radic Biol Med. Merry TL, Ristow M Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? Dillard CJ, Litov RE, Savin WM et al Effects of exercise, vitamin E, and ozone on pulmonary function and lipid peroxidation.

J Appl Physiol. Fisher-Wellman K, Bloomer RJ Acute exercise and oxidative stress: a 30 year history. Dyn Med — Powers SK, Nelson WB, Hudson MB Exercise-induced oxidative stress in humans: cause and consequences. Free Radic Biol Med — Powers SK, Radak Z, Ji LL Exercise-induced oxidative stress: past, present and future.

Sies H Oxidative stress: introductory remarks. In: Sies H ed Oxidative stress. Academic Press, London. Google Scholar. Kassahn KS, Crozier RH, Pörtner HO, Caley MJ Animal performance and stress: responses and tolerance limits at different levels of biological organisation. Biol Rev — Sies H, Jones D Oxidative stress.

In: Fink G ed Encyclopedia of stress, 2nd edn. Academic Press, London, pp 45— Chapter Google Scholar. Birben E, Sahiner UM, Sackesen C et al Oxidative stress and antioxidant defense.

World Allergy Organ J — Gomes EC, Silva AN, De OMR Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev. Ji LL Oxidative stress during exercise: implication of antioxidant nutrients.

He F, Li J, Liu Z et al Redox mechanism of reactive oxygen species in exercise. Front Physiol — Nikolaidis MG, Kyparos A, Spanou C et al Redox biology of exercise: an integrative and comparative consideration of some overlooked issues.

J Exp Biol — Lushchak VI Free radicals, reactive oxygen species, oxidative stress and its classification. Chem Biol Interact — Boveris A, Oshino N, Chance B The cellular production of hydrogen peroxide.

Biochem J — Sen CK Glutathione homeostasis in response to exercise training and nutritional supplements. Mol Cell Biochem — St-Pierre J, Buckingham JA, Roebuck SJ, Brand MD Topology of superoxide production from different sites in the mitochondrial electron transport chain.

J Biol Chem — Wei L, Salahura G, Boncompagni S et al Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB — Alessio HM Exercise-induced oxidative stress.

Med Sci Sport Exerc — Bailey DM, Young IS, McEneny J et al Regulation of free radical outflow from an isolated muscle bed in exercising humans. Am J Physiol Heart Circ Physiol H—H Powers SK, Jackson MJ Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production.

Physiol Rev. Vollaard NBJ, Shearman JP, Cooper CE Exercise-induced oxidative stress: myths, realities and physiological relevance.

Sports Med — Di Meo S, Venditti P Mitochondria in exercise-induced oxidative stress. Biol Signals Recept — Nishino T, Okamoto K, Kawaguchi Y et al Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: Identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant.

Rasmussen JT, Rasmussen MS, Petersen TE Cysteines involved in the interconversion between dehydrogenase and oxidase forms of bovine xanthine oxidoreductase.

J Dairy Sci — Hellsten Y, Ahlborg G, Jensen-Urstad M, Sjodin B Indication of in vivo xanthine oxidase activity in human skeletal muscle during exercise. Acta Physiol Scand — Sahlin K, Ekberg K, Cizinsky S Changes in plasma hypoxanthine and free radical markers during exercise in man.

Hellsten-Westing Y, Balsom PD, Norman B, Sjödin B The effect of high-intensity training on purine metabolism in man. Gomez-Cabrera MC et al Effect of xanthine oxidase-generated extracellular superoxide on skeletal muscle force generation.

Am J Physiol Regul Integr Comp Physiol —8. Wiecek M, Maciejczyk M, Szymura J et al Impact of single anaerobic exercise on delayed activation of endothelial xanthine oxidase in men and women. Halliwell B, Gutteridge JM Free radicals in biology and medicine, 5th edn.

Oxford University Press. Book Google Scholar. Ji LL, Leichtweis S Exercise and oxidative stress: sources of free radicals and their impact on antioxidant systems.

Age Omaha — Article CAS PubMed Central Google Scholar. Bejma J, Ji LL Aging and acute exercise enhance free radical generation in rat skeletal muscle. J Appl Physiol — Sakellariou GK, Vasilaki A, Palomero J et al Studies of mitochondrial and nonmitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase s in the increased skeletal muscle superoxide generation that occurs during contractile activity.

Antioxid Redox Signal — Pearson T, Kabayo T, Ng R et al Skeletal muscle contractions induce acute changes in cytosolic superoxide, but slower responses in mitochondrial superoxide and cellular hydrogen peroxide. PLoS ONE 9:e Fielding RA, Manfredi TJ, Ding W et al Acute phase response in exercise III.

Neutrophil and IL-1β accumulation in skeletal muscle. Am J Physiol Regul Integr Comp Physiol. Belcastro AN, Arthur GD, Albisser TA, Raj DA Heart, liver, and skeletal muscle myeloperoxidase activity during exercise.

Suzuki K Exhaustive exercise-induced neutrophil-associated tissue damage and possibility of its prevention. J Nanomed Biother Discov — Suzuki K, Nakaji S, Yamada M et al Impact of a competitive marathon race on systemic cytokine and neutrophil responses. Med Sci Sports Exerc — Peake JM, Neubauer O, Gatta PAD, Nosaka K Muscle damage and inflammation during recovery from exercise.

Toumi H, Best TM The inflammatory response: friend or enemy for muscle injury? Br J Sports Med — Pyne DB Regulation of neutrophil function during exercise.

Smith JA Neutrophils, host defense, and inflammation: a double-edged sword. J Leukoc Biol 56 6 — Quindry JC, Stone WL, King J, Broeder CE The effects of acute exercise on neutrophils and plasma oxidative stress. Suzuki K, Sato H, Kikuchi T et al Capacity of circulating neutrophils to produce reactive oxygen species after exhaustive exercise.

Bury TB, Pirnay F Effect of prolonged exercise on neutrophil myeloperoxidase secretion. Int J Sports Med — Camus G, Pincemail J, Ledent M et al Plasma levels of polymorphonuclear elastase and myeloperoxidase after uphill walking and downhill running at similar energy cost.

Wetzstein CJ, Shern-Brewer RA, Santanam N et al Does acute exercise affect the susceptibility of low density lipoprotein to oxidation? Paravati S, Rosani A, Warrington SJ Physiology, catecholamines. In: StatPearls. StatPearls Publishing, Treasure Island. Zouhal H, Jacob C, Delamarche P, Gratas-Delamarche A Catecholamines and the effects of exercise, training and gender.

Sellami M, Ben AA, Casazza GA et al Effect of age and combined sprint and strength training on plasma catecholamine responses to a Wingate-test. Eur J Appl Physiol — Thacker JS, Middleton LE, McIlroy WE, Staines WR The influence of an acute bout of aerobic exercise on cortical contributions to motor preparation and execution.

Physiol Rep — Messan F, Tito A, Gouthon P et al Comparison of catecholamine values before and after exercise-induced bronchospasm in professional cyclists. Tanaffos — PubMed PubMed Central Google Scholar.

Ghimire LV, Kohli U, Li C et al Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise. Pharmacogenet Genomics — Kruk J, Kotarska K, Aboul-Enein BH Physical exercise and catecholamines response: benefits and health risk: possible mechanisms.

Free Radic Res 54 2—3 — Lippi G, Sanchis-Gomar F Epidemiological, biological and clinical update on exercise-induced hemolysis.

Ann Transl Med — Cooper CE, Vollaard NB, Choueiri T, Wilson MT Exercise, free radicals and oxidative stress. Çimen MYB Free radical metabolism in human erythrocytes.

Clin Chim Acta — Mohanty JG, Nagababu E, Rifkind JM Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging. Front Physiol —6. Nyakundi BB, Erdei J, Tóth A et al Formation and detection of highly oxidized hemoglobin forms in biological fluids during hemolytic conditions.

Johnson RM, Goyette G, Ravindranath Y, Ho YS Hemoglobin autoxidation and regulation of endogenous H 2 O 2 levels in erythrocytes. Misra HP, Fridovich I The generation of superoxide radical during the autoxidation of hemoglobin. Brzzeszczynska J, Pieniazek A, Gwozdzinski L et al Structural alterations of erythrocyte membrane components induced by exhaustive exercise.

Appl Physiol Nutr Metab — Gwozdzinski K, Pieniazek A, Brzeszczynska J et al Alterations in red blood cells and plasma properties after acute single bout of exercise. Sci World J. Steinbacher P, Eckl P Impact of oxidative stress on exercising skeletal muscle.

Biomolecules — Radak Z, Hart N, Marton O, Koltai E Regular exercise results in systemic adaptation against oxidative stress. Syst Biol Free Radic Antioxid. Valko M, Izakovic M, Mazur M et al Role of oxygen radicals in DNA damage and cancer incidence. Valko M, Rhodes CJ, Moncol J et al Free radicals, metals and antioxidants in oxidative stress-induced cancer.

Reid MB, Shoji T, Moody MR, Entman ML Reactive oxygen in skeletal muscle. Extracellular release of free radicals. Murrant CL, Reid MB Detection of reactive oxygen and reactive nitrogen species in skeletal muscle.

Microsc Res Tech — Ji LL Antioxidant signaling in skeletal muscle: a brief review. Exp Gerontol — Morgan MJ, Liu Z Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res — Yavari A, Javadi M, Mirmiran P, Bahadoran Z Exercise-induced oxidative stress and dietary antioxidants.

Asian J Sports Med —7. Gomez-Cabrera M-C, Domenech E, Viña J Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Nikolaidis MG, Margaritelis NV, Paschalis V et al Common questions and tentative answers on how to assess oxidative stress after antioxidant supplementation and exercise.

In: Lamprecht M ed Antioxidants and redox signaling. CRC Press, pp 1— Margaritelis NV, Veskoukis AS, Paschalis V et al Blood reflects tissue oxidative stress: a systematic review. Biomarkers — Marrocco I, Altieri F, Peluso I Measurement and clinical significance of biomarkers of oxidative stress in humans.

Dalle-Donne I, Rossi R, Colombo R et al Biomarkers of oxidative damage in human disease. Clin Chem — Gulcin İ Antioxidants and antioxidant methods: an updated overview. Arch Toxicol 94 3 — Di Meo S, Napolitano G, Venditti P Mediators of physical activity protection against ros-linked skeletal muscle damage.

Int J Mol Sci — Powers SK, DeRuisseau KC, Quindry J, Hamilton KL Dietary antioxidants and exercise. J Sports Sci — Noori S An overview of oxidative stress and antioxidant defensive system.

Open Access Sci Rep —9. Reid MB Free radicals and muscle fatigue: of ROS, canaries, and the IOC. Shindoh C, DiMarco A, Thomas A et al Effect of N -acetylcysteine on diaphragm fatigue. Ferreira LF, Campbell KS, Reid MB Effectiveness of sulfur-containing antioxidants in delaying skeletal muscle fatigue.

Katz A, Hernández A, Caballero DMR et al Effects of N -acetylcysteine on isolated mouse skeletal muscle: contractile properties, temperature dependence, and metabolism. Pflugers Arch Eur J Physiol — Reid MB, Stokić DS, Koch SM et al N -acetylcysteine inhibits muscle fatigue in humans.

J Clin Invest — Medved I, Brown MJ, Bjorksten AR et al N -acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals.

Slattery KM, Dascombe B, Wallace LK et al Effect of N -acetylcysteine on cycling performance after intensified training. Reardon TF, Allen DG Time to fatigue is increased in mouse muscle at 37 °C; the role of iron and reactive oxygen species.

Antioxid Redox Signal 15 9 — Debold EP Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species.

Front Physiol —7. Close GL, Hamilton DL, Philp a, et al New strategies in sport nutrition to increase exercise performance. Speakman JR, Selman C The free-radical damage theory: accumulating evidence against a simple link of oxidative stress to ageing and lifespan.

BioEssays — Dekkers JC, van Doornen LJ, Kemper HC The role of antioxidant vitamins and enzymes in the prevention of exercise-induced muscle damage.

Vida K, Robinson N, Ives SJ Exercise performance and physiological responses: the potential role of redox imbalance. Ji LL, Gomez-Cabrera MC, Vina J Exercise and hormesis: activation of cellular antioxidant signaling pathway.

Ann N Y Acad Sci — Pingitore A, Lima GPP, Mastorci F et al Exercise and oxidative stress: potential effects of antioxidant dietary strategies in sports.

Nutrition 31 7—8 — Gomez-Cabrera M-C, Viña J, Ji LL Interplay of oxidants and antioxidants during exercise: implications for muscle health. Phys Sportsmed — Theodorou A, Nikolaidis MG, Paschalis V et al No effect of antioxidant supplementation on muscle performance and blood redox status adaptations to eccentric training.

Am J Clin Nutr. Ferran M, Sanchis-Gomar F, Lavie CJ et al Do antioxidant vitamins prevent exercise-induced muscle damage? A systematic review. Antioxidants — Radak Z, Chung HY, Goto S Systemic adaptation to oxidative challenge induced by regular exercise.

Curr Top Nutraceutical Res — CAS Google Scholar. Evans WJ Vitamin E, vitamin C, and exercise. Pehlivan FE Vitamin C: an antioxidant agent. Intech, pp 24— Finaud J, Lac G, Filaire E Oxidative stress: relationship with exercise and training. Traber MG, Stevens JF Vitamins C and E: beneficial effects from a mechanistic perspective.

García-Closas R, Berenguer A, José Tormo M et al Dietary sources of vitamin C, vitamin E and specific carotenoids in Spain. Br J Nutr — Lee SK, Kader AA Preharvest and postharvest factors influencing vitamin C content of horticultural crops. Postharvest Biol Technol — Padayatty SJ, Katz A, Wang Y et al Vitamin C as an antioxidant: evaluation of its role in disease prevention.

J Am Coll Nutr — Tauler P, Aguiló A, Gimeno I et al Influence of vitamin C diet supplementation on endogenous antioxidant defences during exhaustive exercise. Pflugers Arch — Peake J Vitamin C: effects of exercise and requirements with training. Int J Sport Nutr Exerc Metab — Bloomer RJ, Goldfarb AH, McKenzie MJ Oxidative stress response to aerobic exercise: comparison of antioxidant supplements.

Bryer SC, Goldfarb HA Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise. Popovic LM, Mitic NR, Miric D et al Influence of vitamin C supplementation on oxidative stress and neutrophil inflammatory response in acute and regular exercise.

Oxid Med Cell Longev —7. Zoppi CC, Hohl R, Silva FC et al Vitamin C and e supplementation effects in professional soccer players under regular training. J Int Soc Sports Nutr — FASEB J — Meister A Glutathione-ascorbic acid antioxidant system in animals.

J Hepatol. Sotler R, Poljšak B, Dahmane R et al Prooxidant activities of antioxidants and their impact on health.

Acta Clin Croat — Acta Biochim Pol — Asplund KUM, Jansson PJ, Lindqvist C, Nordstöm T Measurement of ascorbic acid vitamin C induced hydroxyl radical generation in household drinking water.

Free Radic Res 36 12 — Poljsak B, Ionescu JG Pro-oxidant vs. antioxidant effects of vitamin C. In: Handbook of vitamin C research: daily requirements, dietary sources and adverse effects. Nova Science Publishers, Inc, New York, pp — Kaźmierczak-Barańska J, Boguszewska K, Adamus-Grabicka A, Karwowski BT Two faces of vitamin c—antioxidative and pro-oxidative agent.

Yimcharoen M, Kittikunnathum S, Suknikorn C et al Effects of ascorbic acid supplementation on oxidative stress markers in healthy women following a single bout of exercise. J Int Soc Sports Nutr —9. Cholewa J, Poprzęcki S, Zajac A, Waskiewicz Z The influence of vitamin C on blood oxidative stress parameters in basketball players in response to maximal exercise.

Sci Sports — Bailey DM, Williams C, Betts J et al Oxidative stress, inflammation and recovery of muscle function after damaging exercise: effect of 6-week mixed antioxidant supplementation.

Mason SA, Baptista R, Della Gatta PA et al High-dose vitamin C supplementation increases skeletal muscle vitamin C concentration and SVCT2 transporter expression but does not alter redox status in healthy males.

Cobley JN, McHardy H, Morton JP et al Influence of vitamin C and vitamin e on redox signaling: implications for exercise adaptations. Poulab E, Sajedinia H, Hafezi F et al The effect of a four-week acute vitamin C supplementation on the markers of oxidative stress and inflammation following eccentric exercise in active men.

Int J Basic Sci Appl Res — Gomez-Cabrera M-C, Domenech E, Romagnoli M et al Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr — Nikolaidis MG, Kerksick CM, Lamprecht M, McAnulty SR Does vitamin C and e supplementation impair the favorable adaptations of regular exercise?

Paulsen G, Hamarsland H, Cumming KT et al Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training.

Bates CJ, Jones KS, Bluck LJC Stable isotope-labelled vitamin C as a probe for vitamin C absorption by human subjects. Levine M, Padayatty SJ, Espey MG Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.

Adv Nutr — Davison G, Gleeson M The effects of acute vitamin C supplementation on cortisol, interleukin-6, and neutrophil responses to prolonged cycling exercise. Eur J Sport Sci — Bohlooli S, Rahmani-Nia F, Babaei P, Nakhostin-Roohi B Influence of vitamin C moderate dose supplementation on exercise-induced lipid peroxidation, muscle damage and inflammation.

Med Dello Sport — Righi NC, Schuch FB, De Nardi AT et al Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials.

Eur J Nutr. Eur J Nutr —9. Margaritelis NV, Kyparos A, Paschalis V et al Reductive stress after exercise: the issue of redox individuality. Redox Biol — Gore M, Fiebig R, Hollander J et al Endurance training alters antioxidant enzyme gene expression in rat skeletal muscle.

Can J Physiol Pharmacol. Hollander J, Fiebig R, Gore M et al Superoxide dismutase gene expression in skeletal muscle: fiber-specific adaptation to endurance training. Lambertucci RH, Levada-Pires AC, Rossoni LV et al Effects of aerobic exercise training on antioxidant enzyme activities and mRNA levels in soleus muscle from young and aged rats.

Mech Ageing Dev. Lawler JM, Powers SK, Van Dijk H et al Metabolic and antioxidant enzyme activities in the diaphragm: effects of acute exercise. Respir Physiol. Hollander J, Fiebig R, Gore M et al Superoxide dismutase gene expression is activated by a single bout of exercise in rat skeletal muscle.

Hitomi Y, Watanabe S, Kizaki T et al Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta. Peake JM, Markworth JF, Nosaka K et al Modulating exercise-induced hormesis: does less equal more?

Li L, Kang C, Zhang Y Exercise-induced hormesis and skeletal muscle health. Radak Z, Ishihara K, Tekus E et al Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve. Ito N, Ruegg UT, Kudo A et al Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy.

Nat Med. Abruzzo PM, Esposito F, Marchionni C et al Moderate exercise training induces ros-related adaptations to skeletal muscles. Jager S, Handschin C, St J, Spiegelman BM AMP-activated protein kinase AMPK action in skeletal muscle via direct phosphorylation of PGC-1a.

They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.

Abstract Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. There is no real need of using a taxonomy, or boolean terms, such as AND or OR they work, but are rarely needed.

If you are really fond of this kind of search strategies, you can use our advanced search. You can search in your own language or in English.

You can even combine terms from different languages. or Registrieren. Erweiterte Suche Help. For instance, vitamin C cold vaccine autism There is no real need of using a taxonomy, or boolean terms, such as AND or OR they work, but are rarely needed.

Effects of ascorbic acid and carbohydrate ingestion on exercise induced oxidative stress. Recent Activity. Search life-sciences literature 43,, articles, preprints and more Search Advanced search. This website requires cookies, and the limited processing of your personal data in order to function.

By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. Vasankari T 1 ,. Kujala U ,. Sarna S ,. Ahotupa M. Affiliations 1. Department of Physiology, University of Turku, Finland. Authors Vasankari T 1.

Share this article Share with email Share with twitter Share with linkedin Share with facebook. Abstract Background We studied the effects of supplementation of vitamin C and carbohydrate on acute exercise-induced lipid peroxidation. Methods Experimental design two randomized controlled trials.

Participants 17 endurance athletes. Interventions in study I, nine athletes repeated twice a In study II, eight athletes repeated twice a km maximal run and ingested in randomly either g carbohydrate or placebo.

Venous blood samples were taken before the exercise, immediately after the exercise, and after a recovery period of 90 min study I or min study II. Measure serum diene conjugation, lipid peroxidation. Results In study I, there was no difference in serum diene conjugation between the trials during exercise pre- vs post-exercise.

In study II, there was no difference between the carbohydrate and placebo trials. Conclusions Vitamin C and carbohydrate do not prevent exercise-induced increase in oxidative stress, but vitamin C, being a potent aqueous antioxidant, seems to decrease the levels of diene conjugation during recovery after exercise.

The clinical significance of this phenomenon needs further evaluation. Vitamin C and glutathione supplementation: a review of their additive effects on exercise performance. Lee E , Park HY , Kim SW , Kim J , Lim K Phys Act Nutr , 27 3 , 30 Sep Cited by: 0 articles PMID: PMCID: PMC Review Articles in the Open Access Subset are available under a Creative Commons license.

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Bjelakovic G , Nikolova D , Gluud LL , Simonetti RG , Gluud C Cochrane Database Syst Rev , 3 :CD, 14 Mar Cited by: articles PMID: PMCID: PMC Review Free full text in Europe PMC.

Effect of a special carbohydrate-protein cake on oxidative stress markers after exhaustive cycling in humans. Kerasioti E , Kiskini A , Veskoukis A , Jamurtas A , Tsitsimpikou C , Tsatsakis AM , Koutedakis Y , Stagos D , Kouretas D , Karathanos V Food Chem Toxicol , 50 8 , 17 Apr Cited by: 21 articles PMID: Antioxidant supplementation during exercise training: beneficial or detrimental?

Peternelj TT , Coombes JS Sports Med , 41 12 , 01 Dec Cited by: articles PMID: Review. Carbohydrate administration and exercise performance: what are the potential mechanisms involved? Karelis AD , Smith JW , Passe DH , Péronnet F Sports Med , 40 9 , 01 Sep Cited by: 37 articles PMID: Review.

Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Increased serum and low-density-lipoprotein antioxidant potential after antioxidant supplementation in endurance athletes. Vasankari TJ , Kujala UM , Vasankari TM , Vuorimaa T , Ahotupa M Am J Clin Nutr , 65 4 , 01 Apr Cited by: 29 articles PMID: Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans.

Morrison D , Hughes J , Della Gatta PA , Mason S , Lamon S , Russell AP , Wadley GD Free Radic Biol Med , , 19 Oct Cited by: 86 articles PMID: