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Top 10 Vitamins, Minerals \u0026 Supplements to FIX DIABETES \u0026 BLOOD SUGAR!Daniyal Abdali Antioxifant, Sue E. FprAshok Kumar Grover; How Effective Are Antioxidant Supplements in Obesity and Supplementw. Med Green building materials Pract 1 Superfood supplement for immune system boost ; 24 3 : — Obesity is a central health issue due to its epidemic prevalence and its association Antioxiadnt type 2 diabetes and other comorbidities.
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Such antioxidant foods are commonly available. Obesity and the associated comorbidities such as diabetes and cardiac diseases are lead causes of human morbidity diabeets mortality.
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The Antioxidant supplements for diabetes management Health Organization Diabtes defines obesity Stress relief through laughter a condition of abnormal or excessive fat accumulation in Amazon Designer Brands tissue such that health may be impaired [ 3 ].
Clinically, in adults, obesity is defined as having a body mass index BMI greater than 30, specifically, with an abnormal fat distribution. The Mood enhancer music distribution diaebtes fat diabetds a risk factor dibaetes obesity and its comorbidities.
Obesity accompanies major systemic changes Herbal pick-me-up tonic the body. Diagetes or visceral obesity is associated with an elevated outflow of free diabeges acids Mabagement from the visceral fat depots supplemments metabolic dysregulation, including insulin resistance [ 4 ].
Hypertrophied intra-abdominal adipocytes may undergo hyperlipolysis, leading to an diagetes flow of Atnioxidant to various organs, including the liver. The spplements in FFA flow may impair liver function, leading to increased hepatic glucose production and insulin Antioxidant supplements for diabetes management.
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Obesity also involves Anhioxidant in diabftes molecules such as leptin, adiponectin and endothelium adhesion molecules. Fo probable explanation is that manafement intra-abdominal fat Fermented foods for overall wellbeing a marker of the Plant-based caffeine source of subcutaneous adipose tissue to store the excess energy.
This inability of the subcutaneous tissue to hold onto the extra fat, known as ectopic fat deposition, results in the excess fat being stored at undesired sites such as the liver, the skeletal muscle and the heart, as well as in pancreatic β cells [ 5 ]. The increased force of the fat mass leads to difficulties in locomotion and pain in the back, hip, knee, ankle, or foot.
Furthermore, the joints, tendons, fascia, and cartilage are all affected because they have to compensate for the increased weight on the knee joint. The weight-bearing joints may subsequently develop osteoarthritis. Insulin resistance and metabolic syndrome increase the risk factor for cardiovascular diseases [ 6 ].
Circulating FFA together with other factors may lead to increased levels of low-density lipoprotein LDLwhich in turn would increase the size of atherosclerotic plaques. Plaques can lead to thrombosis and myocardial infarctions. Excess soft tissue and fat in the chest wall decreases respiratory muscle compliance, functional residual capacity and total volume, which leads to a mismatch in ventilation-perfusion [ 6 ].
It has been suggested that obstructive sleep apnea may be in the causal pathway between obesity and asthma [ 6 ]. Obesity may also increase the risk factor for certain types of cancer. Diabetes associated with obesity has the highest morbidity and mortality burden and will be the focus of this review.
The crudest, simplest and commonest way of measuring obesity is the BMI. A BMI greater than 30 is the broad clinical diagnosis for obesity. However, its first major pitfall is that it does not indicate the type and the locale of the fat in the body. Individuals with excess fat stores within their abdominal regions as determined by a waist circumference measurement are at particular risk of the adverse health consequences resulting from obesity.
Also, BMI may vary with age, gender and ethnicity. Particularly, BMI would vary considerably during early growth [ 3 ]. Thus, at its best the BMI can be used as a flagging factor but not for the diagnosis of obesity. Even waist circumference may be a better measure of obesity than BMI because it is better associated with abdominal fat.
A study of the Middle East population determined the waist-to-hip ratio to be a better measure of comorbidities associated with obesity [ 7 ]. Techniques currently available for investigating fat distribution include water displacement, dual-energy X-ray absorptiometry, computerized tomography and magnetic resonance imaging.
Water displacement is considered the gold standard in total body fat measurement, but it is time-consuming, inconvenient, not widely available and, most importantly, it does not convey any information about body fat distribution [ 8 ].
Dual-energy X-ray absorptiometry is a relatively accurate test. However, the major downside to this test is the exposure to high doses of ionizing radiation. Computerized tomography is quick and suitable for automated image analysis and reproducible. However, the radiation makes repeated testing prohibitive.
Finally, magnetic resonance imaging does not involve any ionizing radiation exposure. Its accuracy and reproducibility for fat analysis has been validated with cadaveric dissections and through animal models. A clear representation of fat distribution can be obtained with minimal inaccuracies by combining magnetic resonance imaging with computer-assisted diagnostic techniques.
This combined method makes it possible to conduct body fat distribution analysis on a daily basis with relative ease, efficiency and effectiveness [ 8 ].
However, the snag is that these tools are expensive and hence not readily available. Variants in the following three genes have been associated with the risk of obesity: 1 the FTO gene was found through a genome-wide association study to be associated with type 2 diabetes and was further determined to be an obesity gene; 2 a common variant in the MC4R gene was seen to be associated with BMI and, as an extension, obesity, and 3 the PCSK1 gene is associated with obesity.
Current evidence suggests a hypothalamic role for all three genes [ 9 ]. Overall, the evidence for genetic intervention or screening is too immature.
There are large gaps in knowledge, and the findings of the various studies are ethnically dependent. Furthermore, many variants of these genes are not associated with obesity or type 2 diabetes.
Thus, genetic screening is not a viable option until more is known in this field. The screening for obesity may also involve monitoring of metabolic disorders.
The five screening variables used to identify those with metabolic syndrome, as proposed by the National Cholesterol Education Program-Adult Treatment Panel III, are waist circumference, circulating levels of TG and high-density lipoprotein HDLcholesterol, fasting blood glucose FBGand blood pressure.
Note that these criteria combine a physical diagnostic measure with the biochemical ones. Type 1 diabetes, or juvenile diabetes, is due to autoimmune destruction of pancreatic β cells which are normally responsible for producing the hormone insulin. The patient has to be given insulin on a regular basis.
In type 2 diabetes, insulin is either not produced in sufficient amounts or does not elicit the normal response from cells. Insulin is needed to supply glucose to the cells of the heart, skeletal muscle and adipose tissue, mostly via the facultative transporter GLUT4, although low levels of GLUT1 are also present in these cells [ 10,11 ].
Insulin stimulates the translocation of GLUT4-containing vesicles from intracellular stores to the plasma membrane. This results in an immediate to fold increase in glucose transport [ 10 ]. Furthermore, the defect seen in type 2 diabetes may also be a result of impairments in the translocation machinery, as defined by molecules involved in GLUT4 sorting, retention, movement, docking and tethering, and fusion [ 11 ].
In type 2 diabetes, the insulin-dependent increase in the level of surface GLUT4 is defective. Though insulin is not necessary for glucose uptake via the transporters GLUT, GLUT4 transporters are essential for lowering the acute postprandial rise of plasma glucose levels via sensitivity to insulin levels.
Furthermore, since skeletal muscles and adipose tissue are the largest storage areas for glucose, and the GLUT4 transporter is found within them only, the importance of insulin in controlling blood sugar levels after a meal cannot be overstated [ 10 ]. Insulin defects lead to very high plasma levels of glucose which can damage various organs.
Type 2 diabetes may or may not be related to obesity. The management regimens involve mainly a reduction of blood glucose levels using diet and exercise for weight control, drugs which prevent conversion of other metabolites into glucose and, if needed, insulin therapy. Without the proper adipose tissue precursors, the fatty acid storage decreases and the amount of FFA in circulation increases lipotoxicity.
Excess adiposity due to a positive caloric balance leads to the release of inflammatory molecules from central visceral fat depots that lead to insulin resistance and increased concentration of circulating FFA. This cycle keeps perpetuating itself and the increasing amounts of FFA are continuously deposited in muscles and liver fig.
Pathways from excess calorie consumption to obesity and diabetes. The pathophysiology of obesity cannot be explained by insulin resistance alone. Adipose tissue is an organ of energy storage and also actively participates in hormonal regulation of homeostatic systems.
Adipose tissue can be distinguished into two major types: brown and white adipose tissue [ 12 ]. The brown adipose tissue serves as a source of thermogenesis during periods of nonshivering. The white adipose tissue is the majority of adipose tissue in the body and is the site of energy storage.
The number of macrophages present is correlated with the amount of adiposity and the size of the adipocytes. The adipose tissue is also the source of a number of modulatory molecules. Leptin, a satiety hormone, is a kDa protein produced mainly by adipocytes [ 12 ].
: Antioxidant supplements for diabetes management| RESEARCH DESIGN AND METHODS | Researchers are investigating it as a potential treatment for stroke and other brain problems involving free radical damage, such as dementia. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. While there are thousands of antioxidant compounds, some common ones found in foods include favanols found in chocolate , resveratrol found in wine and lycopene found in tomatoes. Apha-lipoic acid can combine with these drugs to lower blood sugar levels, raising the risk of hypoglycemia or low blood sugar. Macular Degeneration. |
| Antioxidants in the Treatment of Diabetes | Antioxidany 1 diabetes, or juvenile diabdtes, is due to Antioxieant destruction of pancreatic Fat-burning gym workouts cells Antioxidant supplements for diabetes management are normally responsible Ffor producing the manahement insulin. The crudest, simplest and commonest way of measuring obesity is the BMI. Possible Interactions If you are being treated with any of the following medications, you should not use alpha-lipoic acid without first talking to your health care provider. How obesity is related to an increase in inflammation which is associated with an increase in oxidative stress is shown in figure 1. Google Scholar. J Investig Med. |
| Good advice, in small doses. | Always ask your oncologist before taking supplemejts herb Antioxidant supplements for diabetes management supplement, Antioxidwnt alpha-lipoic acid. Dietary diabdtes have been hypothesized to Antioxidant supplements for diabetes management a protective effect against the Anrioxidant of diabetes by inhibiting peroxidation chain reactions 2. Conferences Conference Coverage. Related Journals Anti-Cancer Agents in Medicinal Chemistry. Osteoporosis, Osteoarthritis and Rheumatoid Arthritis: An Agonizing Skeletal Triad. The brown adipose tissue serves as a source of thermogenesis during periods of nonshivering. Gunasekara P, Hettiarachchi M, Liyanage C, et al: Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes. |
| Diabetes Supplements: Vitamins, Minerals, And Antioxidants | CAS Majagement Scholar Rauscher F, Sanders Antioxidant supplements for diabetes management, Watkins JI: Effects of Suppkements Q10 treatment on antioxidant mxnagement in normal and streptozotocin-induced diabetic suplpements. Heller R, Gor A, Schellenberg B, Mayer B, Werner-Felmayer G, Cultivating a nourishing relationship with food ER: L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. This Feature Is Available To Subscribers Only Sign In or Create an Account. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. J Clin Invest. Lynch MA. Because the use of vitamin supplements was rare at the time of baseline 40it is apparent that supplement use has not caused misclassification of nutrient intakes. |
Antioxidant supplements for diabetes management -
This is important as pancreatic cells produce insulin. Supplements can also help prevent Vitamin C deficiency and thereby reduce the risk of complications associated with diabetes.
This includes complications like diabetic retinopathy, foot ulcers, and cardiovascular problems. Moreover, vitamin E supplementation slows down the progression of complications in people with uncontrolled diabetes. Studies have reported that the use of thiamine supplements for at least a month decreases blood glucose level in diabetics, also lowering the risk of diabetic nephropathy.
Additionally, it improves serum insulin and insulin resistance in type 2 diabetes patients. When used in combination with other vitamins like Vitamin B6 and Vitamin B12, it can also improve symptoms of diabetic retinopathy.
When supplemented along with lipoic acid, vitamin B12 also improves nerve function, protecting against diabetic neuropathy. Overall, numerous research studies have reported that vitamin supplementation not only improves glycemic control in diabetics but also prevents diabetes-related complications.
Minerals play an equally important role in the management and treatment of diabetes. This is because lack of minerals can impair glucose metabolism, raising the risk of health complications. In fact, diabetes patients often suffer from low levels of magnesium and zinc.
Moreover, low levels of this mineral can impair the secretion of insulin by the pancreas. cassia Chinese cinnamon. Cinnamomum zeylanicum Sri Lankan cinnamon has been tested extensively in animals and shown to be beneficial in diabetes, but the human studies mostly used C.
cassia [ 75 ]. The effectiveness of cinnamon or cinnamon extracts may depend on how well controlled the diabetes was at the beginning of the study. Each study used different parameters and different time periods and most were small studies, which makes comparisons complicated.
The beneficial health effects of tea and green tea have been celebrated in many cultures where tea is the most commonly consumed beverage. However, the word tea is also used as generic term for herbal drinks made in hot water and, therefore, it is clarified that this section focuses on tea made from the leaves of Camellia sinensis.
Tea may be processed and brewed or used as dried green leaves - hence the term green tea which is the focus here. Green tea is rich in catechins and caffeine but also contains vitamins B, C and E, carotene and theanine [ 76 ].
The weight loss peaked at 8 weeks, as did the energy expended. The tea was hypothesized to increase the energy expended through thermogenesis and fat oxidation. This is consistent with the weight loss since the actual activity level or the caloric intake did not change.
An open study conducted in France using 68 overweight to moderately obese patients found a weight loss of 4. This was a completely open study with no control group and it did not mention diet or activity levels during the course of the study.
Interestingly, another open study did not have a significant effect of decaffeinated green tea or green tea supplements over 8 weeks on biomarkers of inflammation in obese subjects [ 79 ].
There was no diet control in this study and no recording of normal caffeine intake. Some populations may be consuming, in a normal day, from 0. Even several soft drinks may contain sufficient caffeine.
The degree to which green tea is effective may change from population to population and over time as some of the effect is due to caffeine - the Thai population consumes less caffeine than the North American or European population - and a tolerance to caffeine can develop.
Also, it is noted that the exact chemical composition of green tea may depend on the cultivars, the region where it is grown, seasonality of harvest, which leaves are harvested, and how the green tea is processed and prepared. It is pointed out that the customs in tea preparations vary and some of them may be beneficial for diabetes.
For example, Kashmiri tea also contains cinnamon and a trace of saffron, which may be beneficial for diabetes [ 82 ]. The typical Indian masala tea does contain the antioxidant containing beneficial spices but is typically made with sugar and milk, which may increase the calorie and fat consumption.
Chlorogenic acid is an antioxidant found in plums prunes , peaches, potatoes, and date palm, as well as in green coffee beans. Green coffee is trendy and publicized on the Internet for its weight loss potential. However, there are very few reliable studies to support this claim.
There are several small short-term ill-controlled studies [ 83,84 ]. A small double-blind crossover trial with 16 preobese participants showed that green coffee extract supplementation resulted in weight loss over a week period [ 83 ].
A meta-analysis in concluded the results with green coffee to be promising but questions the quality of these studies [ 84 ]. Larger-scale well-conducted trials on diabetic patients were not found. Our opinion is that green coffee may be marginally useful due to its chlorogenic acid content.
However, this antioxidant is also available in fruits such as prunes and dates which also contain ferulic acid - another antioxidant which has proved useful in diabetes studies in animals but has not yet been tested in humans [ 85,86 ].
Would the use of these fruits in a regular diet not be more beneficial than the green coffee extract supplements? Resveratrol is a polyphenolic compound found in the skin of red grapes, in fruits such as pomegranates, in berries such as acai and Ziziphus, and in the roots of Japanese knotweed Polygonum cuspidatum.
Red wine is also rich in this antioxidant. It has been shown to be of benefit in cardiovascular function and investigated for potential benefits in diabetes [ 87 ]. In a double-blind study using 19 type 2 diabetic men who were already on oral glucose-lowering drugs, the effect of 5 mg capsules 2× daily for 4 weeks containing resveratrol or placebo was studied [ 88 ].
Resveratrol significantly decreased oxidative stress and insulin resistance. The benefits of this antioxidant have been even fewer in other studies [ 90,91,92 ]. A study using up to 2 g of resveratrol daily for 4 weeks showed a modest decrease in postprandial glucose levels but not in FBG and any other measures [ 90 ].
In another study, the effects of mg resveratrol for 4 weeks in healthy obese men compared to those on placebo showed that endogenous glucose production and the turnover and oxidation rates of glucose remained unchanged [ 91 ].
Resveratrol supplementation also had no effect on blood pressure, resting energy expenditure, oxidation rates of lipids, ectopic or visceral fat content, or inflammatory and metabolic biomarkers.
The study by Yoshino et al. Our opinion is that this antioxidant may be beneficial for health in general, but even as an adjunct therapy for type 2 diabetes its usefulness remains to be established.
Lycopene-rich foods are common and include guava, papaya, watermelon, and solanaceous plants such as tomato, eggplant and potato. Lycopene is a carotenoid and is an antioxidant which has been studied for its anti-inflammatory properties, most often in conjunction with cancer or cardiovascular disease but not as extensively or systematically for obesity or diabetes [ 93 ].
There are several small studies on the therapeutic effects of lycopene on diabetes [ 94,95,96 ]. They did not show any benefits in anthropomorphic data, FBG, HbA 1c , or other markers for impaired glucose tolerance, but some studies showed that it does not have any added value apart from marginal effects on oxidative stress status and inflammation markers IL-6, TNF-α or CRP.
The WHO defines obesity as a condition of abnormal or excessive fat accumulation in adipose tissue, such that health may be impaired. However, this definition is inadequate since it does not include the abnormal distribution of fat which is the main risk factor for obesity and its comorbidities.
The adipocytes in the visceral fat can recruit monocytes which are transformed into macrophages. The adipocytes and macrophages can produce molecules which lead to the metabolic syndrome and release of FFA, terminating in type 2 diabetes.
Obesity and type 2 diabetes are associated with an increase in oxidative stress. Therefore, it would be logical to consider antioxidant supplementation in potential therapy for obesity and diabetes. Here we considered the following types of antioxidants: vitamins and cofactors, polyphenols and carotenoids.
Table 1 contains a summary of the key observations. Briefly, there may be some benefits of long-term consumption of vitamin C through diets containing fruits and vegetables, but the effects of vitamin C and E supplementation are marginal.
Zinc supplements may have benefits which include lowering FBG, postprandial plasma glucose and lipid profiles - and may be even greater when control with medication is poor. Lipoic acid supplementation may be beneficial to some degree in obesity and diabetes.
Carnitine is beneficial for diabetes in lowering FBG, total cholesterol, apolipoprotein-B, and apolipoprotein-A1 but has no effects on TG, HbA 1c or lipoprotein A.
For diabetics, the evidence for the benefits of LCn-3PUFA and coenzyme Q10 is feeble, although the latter seems to have an antihypertensive effect. There is reasonable evidence for benefits of cinnamon in lowering FBG, HbA 1c , oxidative stress, and possibly fat mass.
However, the effectiveness of cinnamon or cinnamon extracts may depend on how well controlled the diabetes is at the beginning of the study. Green tea not decaffeinated may increase thermogenesis and fat oxidation, leading to small weight loss.
Chlorogenic acid in green coffee has, if any, only a small potential for weight loss. Resveratrol reduces oxidative stress and had marginal benefits for diabetes in some studies but not in others. Lycopene may have marginal benefits in decreasing oxidative stress status, IL-6, TNF-α, or CRP but has no effects on weight, FBG, HbA 1c , or impairment of glucose tolerance.
Thus, supplementation with zinc, lipoic acid, carnitine, cinnamon, green tea, and possibly vitamin C plus E had marginal benefits for diabetes. However, the evidence for such benefits from LCn-3PUFA, coenzyme Q10, green coffee, resveratrol, and lycopene was less than convincing.
Recall that only the potential benefits for obesity and diabetes were examined here. However, the various other antioxidants could also have other health benefits which were not considered.
There are several issues in considering the benefits of antioxidants in obesity and type 2 diabetes. The first is the confusion over the definition of obesity.
Typically, this definition is based on BMI, which is inadequate, as are the other anthropomorphic measurements. The concern becomes significantly greater when FBG levels become very high and the risk of insufficiency of secretion and functioning of insulin is realized - then the disease is diagnosed as diabetes.
However, there is a realm of metabolic changes that occur in between, and these may be gradual but chronic and cause low-grade inflammation. Therefore, the researchers investigating the benefits of antioxidants face the dilemma concerning at which stage can subjects be recruited into the studies and what parameters should be measured.
Subjects who are diabetic or near diabetic may be easier to recruit and have greater compliance than those in early stages of obesity where the metabolic syndrome may have begun to set in. Consequently, there is considerable heterogeneity in the literature - in the types of subjects used and the measurements made.
Furthermore, subjects in the advanced stages may already be on different medications, thereby producing the complication of interactions between various treatments and the antioxidants. Another issue is that money is not as plentiful in this field as it is for drug company research. The net result of all these problems is that most studies are small both in the number of subjects and duration.
They also often lack appropriate controls. Many are epidemiological studies or meta-analyses, using the self-reporting of antioxidant intake, which is notoriously prone to error. Also, for intervention studies when natural products are used, their key antioxidant determinants are not reported.
The product quality, stability and absorption of the same antioxidant can vary considerably between the various manufacturers. The source of the intervention is frequently not reported, and this can have a significant impact on whether or not a particular antioxidant will prove to exert a clinical benefit.
Also, the bias due to source of funding and other conflicts of interest cannot be ignored. Hence, it was difficult for us to come up with laser-sharp conclusions for each substance. In most cultures, the availability of plentiful food was a sign of success and satisfaction. However, in today's society this should no longer be true due to a decrease in the amount of physical activity and an increase in high-calorie foods.
Whether it be preobese, obese or type 2 diabetic, the therapy has to begin with an increase in exercise and a decrease in calorie consumption. Having made this statement, it is also clear that antioxidants do have a role in slowing the low-grade inflammation associated with these diseases.
The ideal would be increasing foods rich in antioxidants as part of a lifestyle from an early age table 1. For those who are in more advanced stages of the disease, supplementation with a combination of antioxidants may also be beneficial.
However, ideally it would be the change in lifestyle that leads to the consumption of a balanced diet low in calories and rich in antioxidants. The literature does not suggest antioxidant supplementation as a cure-all for obesity or for type 2 diabetes. This work was supported by internal funds from McMaster University.
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Review Articles March 14 How Effective Are Antioxidant Supplements in Obesity and Diabetes? Topic Article Package: Topic Article Package: Diabetes.
Subject Area: General Medicine. Daniyal Abdali ; Daniyal Abdali. Department of Medicine, HSC 4N41, McMaster University, Hamilton, Ont. This Site. Google Scholar. Sue E.
Samson ; Sue E. Ashok Kumar Grover Ashok Kumar Grover. groverak mcmaster. Med Princ Pract 24 3 : — Article history Received:. Cite Icon Cite. toolbar search Search Dropdown Menu. toolbar search search input Search input auto suggest.
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The authors have no conflicts of interest to declare. Behbehani K: Kuwait National Programme for Healthy Living: first 5-year plan Med Princ Pract ;23 suppl 1 Hotamisligil GS: Inflammation and metabolic disorders.
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Vashum KP, McEvoy M, Shi Z, et al: Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women's health. BMC Endocr Disord ; Diabetes is one such example. Researchers report that diabetics have increased blood concentrations of the byproduct from lipid peroxidation, called thiobarbituric acid reactive substances.
It is thought that antioxidants can intervene and bring the body back into a more natural state with less oxidative stress. Vitamin E is oil soluble and has a strong affinity for cell membranes that are mainly made up of lipids and fats.
Vitamin E is also used in grocery stores to keep raw meat looking fresh by preventing it from turning a grayish brown when exposed to air. It is also used in fish oils to prevent the oil from turning rancid.
It was no surprise that it performed so well in the meta-analysis. To a lesser degree, vitamin C also performed well.
It is water soluble and can go where vitamin E cannot, since oil and water do not mix. Vitamin C is known for keeping freshly cut fruit from becoming discolored when cut open and exposed to air. The meta-analysis briefly mentioned good results from glutathione, a water soluble antioxidant that many people believe is the most potent antioxidant that our body manufactures.
It is currently being used in hospitals to counteract the negative effects of toxin exposure. Unfortunately, the meta-analysis did not mention Alpha-lipoic acid ALA. ALA is another potent antioxidant that our bodies make, and is used in hospitals to counteract nerve toxicities that can be associated with chemotherapy.
It is soluble in water and oil and therefore can go anywhere in the body. It has been used in patients with diabetes. In nature, antioxidants are found together in groups. Never does a fruit or vegetable contain just one antioxidant alone.
Even vitamin E is found in groups called tocotrienols. Along that same train of thought, multiple studies have noted antioxidant synergy. These biochemicals lose and gain electrons as they perform the desired reactions. After the desired action occurs, the biochemical has to either get rid of the extra electron, or find more electrons so that it can begin again and perform the same desired actions.
With synergy, the antioxidants toss the unncessary electrons back and forth to regenerate their abilities. Antioxidants are being used experimentally in patients with dementia, systemic inflammation, cancers, and heart disease.
Smoking, excessive alcohol intake, and illicit drug use can lead to heart damage in people as young as in their 30s. There are biomarkers proving that the oxidative damage from these choices are affecting the heart muscle. Bad health is a downward spiral and can be accelerated by oxidative stress.
Researchers are working hard to understand how they can effectively and reliably intervene in disease states. Until they do, we must intervene with our lifestyle choices, when we can. Frijhoff J, Winyard PG, Zarkovic N, et al.
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Diabetes Care. Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. FDA Approves Iloprost Injection For the Treatment of Adults With Severe Frostbite. Public Health Matters: The Pharmacist's Role in the HIV Space, Removing Barriers, Racial Disparities.
Common Osteoporosis Treatment May Reduce Risk of Incident Diabetes. Pharmacy Focus Oncology: Advancements in Hematology and Breast Cancer - ASH and SABCS Recap. Increased Development of RSV Immunoprophylaxis Inhibited by Cost and Acquisition Barriers.
Eliminating Hepatitis C Virus Infections in Individuals who Inject Drugs: A Novel Model of Community Pharmacy Care. All News.
Editor-in-Chief: Antioxidant supplements for diabetes management E. Cameron Department of biomedical Diabetea Sciences NIL University of Aberdeen Aberdeen United Kingdom. ISSN Print : ISSN Online : DOI: Diabetes is a chronic metabolic disorder that continues to present as a major health problem worldwide.
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