Ststin it was beyond the scope of this paper to elucidate Support healthy cholesterol levels slimming pills mechanism behind the increased intrinsic Coenzyne respiratory capacity, we speculate it is a consequence of impaired plasticity of the mitochondrial network. Sign In or Create an Account. Karoline Maise Chrøis. Abstract Background. View Large Download. However, statins are still widely used and their safety is still debated.

Coenzyme Q and statin therapy -

It is also worth noting that, as serum CoQ10 is transported by lipoproteins such as LDL, the reduction in plasma CoQ10 levels after treatment with statins may be at least partly attributed to reduced levels of LDL.

Although reductions in plasma CoQ10 levels have been observed after treatment with statins, 7 it is unclear whether this is accompanied by a reduction in intramuscular CoQ10 levels.

Although CoQ10 deficiency has been associated with various conditions and disorders, the consequences of reduced plasma CoQ10 levels in individuals following statin treatment remain unclear. As CoQ10 deficiency has been associated with myopathies, 20 multiple studies have investigated whether CoQ10 supplementation can improve muscle symptoms associated with statin use.

To date, there have been mixed results across trials on the effect of CoQ10 supplementation on muscle symptoms in patients taking statins. Although some small studies have reported a significant reduction in muscle symptoms with CoQ10 supplementation, others have shown no significant benefit.

A meta-analysis performed in assessed outcomes from 7 RCTs with people included in total. Overall, the authors concluded that CoQ10 did not have a significant effect on reducing muscle pain compared with placebo.

Although Australian guidelines for management of absolute CV risk and hypertension do not provide specific guidance on use of CoQ10, 1 , 31 a European Atherosclerosis Society consensus statement notes that CoQ10 supplementation is not recommended to treat or prevent SAMS.

If improvement in symptoms is reported, a trial of stopping and restarting CoQ10 therapy could be considered to establish causality. Consultant physician, Royal Perth Hospital Winthrop Professor, School of Medicine and Pharmacy, University of Western Australia.

It is important to promptly assess the signs and symptoms of all patients who present with suspected SAMS. This can help to minimise the risk of compromising adherence to statins, and to differentiate symptoms that may be suggestive of rarer and more severe myopathies.

If the muscle symptoms are indeed associated with statin use, confirm there is an appropriate indication for statin use before proceeding to trial management strategies as listed in the SAMS management algorithm.

Consider strategies such as reducing statin dose, intermittent dosing or switching the type of statin before making a change in cholesterol-lowering medicine, to ensure patients are not left without the benefits of statins for primary or secondary prevention of CVD.

Reasonable care is taken to provide accurate information at the time of creation. This information is not intended as a substitute for medical advice and should not be exclusively relied on to manage or diagnose a medical condition. NPS MedicineWise disclaims all liability including for negligence for any loss, damage or injury resulting from reliance on or use of this information.

Read our full disclaimer. This website uses cookies. Read our privacy policy. Skip to main content. Log in Log in All fields are required. Log in. Forgot password? Home News Can co-enzyme Q10 supplementation prevent or treat statin-associated muscle symptoms? Can co-enzyme Q10 supplementation prevent or treat statin-associated muscle symptoms?

Subscribe to NPS MedicineWise. Key points Co-enzyme Q10 CoQ10 is an antioxidant produced by the cholesterol biosynthesis pathway. Treatment with statins has been associated with reduced plasma CoQ10 levels, and it has been hypothesised that supplementation with CoQ10 may assist with management of statin-associated muscle symptoms SAMS.

Evidence supporting the use of CoQ10 supplements to prevent or treat SAMs in clinical practice is inconsistent. If a patient chooses to take a CoQ10 supplement, exercise caution in those taking oral anticoagulants such as warfarin due to potential for interactions.

Promptly assess suspected SAMS and implement appropriate management strategies to minimise the risk of compromising patient adherence to statins. What is co-enzyme Q10? Statin treatment associated with reduction in plasma CoQ10 levels In addition to the well-known effect of statins on low-density lipoprotein cholesterol LDL-C via inhibition of HMG-CoA reductase, 17,18 a meta-analysis of 6 RCTs demonstrated that statin treatment is also associated with significant reductions in plasma CoQ10 concentrations.

Does CoQ10 supplementation improve statin-associated muscle symptoms? What does this mean in practice? Expert commentary.

So what are effective management strategies for suspected SAMS? References National Vascular Disease Prevention Alliance. Guidelines for the management of absolute cardiovascular disease risk.

Therapeutic Guideline Ltd eTG March edition : Lipid modification. West Melbourne: Australian Therapeutic Guidelines Limited, accessed 20 September Stroes ES, Thompson PD, Corsini A, et al.

Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J ; NICE guidance on cardiovascular disease: risk assessment and reduction, including lipid modification , does not support the use of coenzyme Q10 supplements as a strategy to improve adherence to statin therapy due to insufficient evidence.

The guideline development group concluded that the use of coenzyme Q10 supplements for statin-induced muscle symptoms is not cost-effective as there is no clinical evidence in favour of benefit from its use.

There are no studies that directly assess the clinical and economic impact of coenzyme Q10 supplementation on adherence to statin treatment as a primary outcome measure. Do not recommend coenzyme Q10 supplements for the management and prevention of statin-induced muscle symptoms.

NICE advises exploring and addressing the problems people are having with taking their statins. Refer to the NICE Clinical Knowledge Summary on statins for general advice to give to people taking statins.

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Show references Coenzyme Q National Center for Complementary and Integrative Health. Accessed Oct. Pizzorono JE, et al. In: Textbook of Natural Medicine.

Elsevier; Coenzyme Q10 PDQ -Health Professional Version. National Cancer Institute. IBM Micromedex. Dluda PV, et al. The impact of coenzyme Q10 on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta-analysis of randomized controlled trials.

Ajd MAYO CLINIC: I have heard that taking coenzyme Q10 is good for snd who take statins. There are so many commercials and ads about it. But is it really necessary to take this supplement? How do I know if I need it? And is liquid better than pill form? How much do I take? CoQ10 may help reduce therpy and improve sttatin health, but more research Allergen-free kitchenware needed to confirm this. Ask your doctor Elderberry syrup for winter health they think taking it Cofnzyme statin medications Antidepressant for performance anxiety sratin you better results. Coenzyme Q10or CoQ10, is a substance that the human body makes naturally. Cells use it to generate energy. CoQ10 also functions as a powerful antioxidant to help fight free radicals that can damage cells and DNA. However, your body produces less and less CoQ10 as you get older. Although your body produces its own CoQ10, you can also get it from certain foods.