Journal blooc Guilan University sugr Medical Sciences Journal of Guilan University of Medical Sciences P. Box:Iran. Mental focus and mindfulness meditation medjour gums. Sugwr, Feb Bone health and women, فارسی [ Bliod ].
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Fod citation: BibTeX RIS EndNote Weight loss slimming pills ProCite Reference Manager RefWorks Send citation to:. Zurantium S, Naserollahzadeh Sugarr, Sovaid M, Setoudehmaram E. Effect balajce Sour Orange Citrus Cihrus L. Juice Consumption on Blood Glucose Weight loss slimming pills Lipid Profile in Diabetic Citrus aurantium for blood sugar balance with Dyslipidemia.
Nalance Views. Abstract Introduction: Sour orange is balane as an fro plant in folk medicine. Previous studies sugr a balanec relationship between the consumption of citrus fruits or juices and risk of some chronic ba,ance. Objective: In this study, the airantium of short-term consumption of sour orange juice on blood glucose and lipid profile of diabetic patients was evaluated.
Materials and Methods: In a clinical trial study before and afterthirty-five 10 men and 25 women dyslipidemic diabetic patients without nephropathy with mean age Each patient consumed ml of sour orange juice daily for 4 weeks. The patients were asked to maintain their usual diet, physical activity and consumption of their oral hypoglycemic agent during the entire experimental period.
Body weight and height were measured at baseline and after consumption of ml of sour orange juice daily for four weeks and BMI was calculated. Fasting blood glucose, lipids and ascorbic acid level were measured at the beginning and the wnd of the study.
Plasma ascorbic acid concentrations were measured by the 2,4 dinitrophenyl hydrazine method with calorimetric analysis. FBS, TG, and total cholesterol were measured by enzymatic method. A 24 hr dietary recall and food frequency questionnaire were analyzed by Nutrition III soft ware.
Data were compared with paired t- test and X2-test as appropriate. Results: there were no statistical significant change in body weight, energy and macronutrient intakes before and after 4 weeks consumption of sour orange juice, but Vitamin C intake significantly p Keywords: Biood GlucoseCitrusDiabetes Mellitus- Type2DyslipidemiaLipids.
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: Citrus aurantium for blood sugar balance| Citrus Bergamot For Blood Sugar & Weight Loss | The Botanical Institute | During treatment, both test and shgar animals were High GI drinks on calorie restriction Citrus aurantium for blood sugar balance being fed with the carbohydrate and fat ba,ance Altromin C Blooe. 혈관의 긴장은 30분 후에 안정상태에 도달하였다. application Ser. J Strength Cond Res. This postulate is supported by the significant reduction in fatty acid deposits in the treated mice eye See FIG. In a PSS tissue chamber, a horizontal walk was made between two stainless steel stirrups. |
| Citrus Bergamot for Blood Sugar & Weight Loss | High blood sugar, medically referred to as hyperglycemia , occurs when there is too much sugar in the blood. Mohr M, Nielsen JJ, Bangsbo J. Antioxidants Basel. Food Sci. Following 3 months of receiving the supplement, the TC levels were reduced by 5. Article Google Scholar Medicine ACoS. |
| Tables of Contents | After 5 weeks, the general status, liver antioxidant ability and the change of livers histological were observed. Results: Experimental diabetic mice groups were treated with C. aurantium extract in comparison with the experimental diabetic mice group. The activities of superoxide dismutase SOD were increased in liver. The composition and content in the bioactive ingredients of the Citrus aurantium and Olea europaea blend have also been previously described in the study by Merola et al All participants were instructed to receive the capsules for 12 weeks and were reassessed after this period, without any instructions for alterations in diet or exercise patterns. Blood samples 5 ml were drawn at the initial patient visit at the outpatient hypertension clinic and following the end of treatment week 12, re-evaluation visit. Statistical analyses were conducted using IBM SPSS software version 29; IBM Corp. The Kolmogorov-Smirnov test was used to assess the normality of the data. The parametric two-sided paired sample t-test was used to compare the blood results before and after supplement administration. The mean TC levels at the initial visit were measured at The average reduction in TC levels was 5. Statistical analysis using the paired t-test indicated that the average TC levels before the administration of the supplement differed from the respective values following treatment. Boxplots of total cholesterol levels, before blue box and after orange box the administration of the supplement. The average measured LDL levels at the initial visit were The mean reduction in LDL levels was 4. Variations in average values after 12 weeks of the daily intake of capsules of the supplement. Statistical analysis using the paired t-test indicated that the mean LDL-C levels prior to the administration of the test capsule differed from the levels after the administration of the capsule. However, the reduction in LDL cholesterol was not statistically significant p. Boxplots of low-density lipoprotein levels, before blue box and after orange box the administration of the supplement. The average values of HDL at the initial medical examination were The average increase in the HDL levels reached 5. Statistical analysis using the paired t-test indicated that the average HDL levels prior to the intake of the supplement differed from the final test results values. The HDL values increased; however, this increase was not statistically significant p. Boxplots of high-density lipoprotein levels, before blue box and after orange box the administration of the supplement. The average values of the TG levels at the initial examination were Following 12 weeks of the daily consumption of two capsules of the test supplement, the TG values were The average decrease was After performing statistical analysis paired t-test , the results revealed a statistically significant decrease following the administration of the capsules for a week period p. Boxplots of triglyceride levels, before blue box and after orange box the administration of the supplement. A summary of the final results of the study regarding the efficacy of the nutritional supplement on the lipid profiles of the study participants is presented in Table II and Fig. Following 3 months of receiving the supplement, the TC levels were reduced by 5. Overall, although the changes in the LDL levels are not deemed statistically significant, a tendency towards an improvement was observed in the results for TC, HDL and TG levels. Median levels of TC, LDL, HDL and TGs at the beginning of the study and after 12 weeks of consumption of the supplement. TC, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TGs, triglycerides. The present open observational prospective study in individuals with mild hyperlipidemia, demonstrated that the nutritional supplement combining plant extracts from Citrus aurantium, Olea europaea leaf and Cistus creticus , administered for a period of 12 weeks, significantly reduced TG levels by The results are consistent with those of previous publications , in which the herbal extracts of the study supplement were studied separately. In both studies, the doses of the extracts used were higher than those used in the present study. Since in the present study, the decrease in TG levels was considerably higher, yet with smaller doses, it can be assumed that this decrease may be attributed to the synergistic effect of the plant extracts. High TG levels are considered a marker of high cholesterol levels in TG-rich lipoproteins, which are associated with low-grade inflammation Hypertriglyceridemia and high levels of TG-rich lipoproteins are considered an independent risk factor for atherosclerotic cardiovascular disease; therefore, any decrease in TG levels may have a beneficial effect on risk reduction. In another study, fasting TG levels were shown to be associated with short- and long-term cardiovascular risk, even in individuals who were treated effectively with statins Additionally, from a multiple single nucleotide polymorphism Mendelian randomization analysis, the genetic findings support a casual effect of TGs on coronary heart disease events Increased levels of TGs are associated with increased levels of remnant cholesterol and with reduced levels of HDL-C On the other hand, HDL-C is important for the lipid transportation and metabolism, due to the removal of the excess cholesterol from peripheral tissues, but also for its anti-inflammatory and antioxidant properties 27 , 28 , attributed to the associated enzyme paraoxonase 1 PON1 PON1 binds to HDL-C and increases its antioxidant anti-atherogenic effects In the present study, a marked increase of 3. Since it is widely accepted that HDL-C is critical due to its anti-atherogenic properties in mediating cholesterol transport from peripheral tissues to the liver 31 , an increase in HDL-C alongside with a significant decrease in TG levels appears to be beneficial for individuals with mild cardiovascular risk factors. The blend of ingredients which was used in the present study, has been previously suggested to improve PON1 activity in parallel with an increase in HDL-C levels and a decrease in TG levels Moreover, supplementation with a water infusion of Cistus incanus also known as Cistus criticus 32 , has been demonstrated to exert antioxidant effects by significantly decreasing the malondialdehyde and advanced oxidative protein product concentrations in healthy volunteers Recently, Cistus incanus extract, through its potent antioxidant activity due to its high content of flavonoids, was proven to attenuate the negative effects of high fat-carbohydrates on erythrocytes in animal models It has also been demonstrated in vitro to have the ability to decrease the overproduction of reactive carbonyl species, particularly advanced glycation end products, which function as a prooxidant and pro-inflammatory agent in the organism Cistus creticus is considered to be an excellent source of natural antioxidants and the European Food Safety Authority included it in its scientific opinion In previous research, the administration of polyphenol-rich olive leaf extracts was found to significantly lower the serum levels of TC, TGs and LDL-C, and to increase the serum level of HDL-C. These extracts were found to increase the serum antioxidant potential and the hepatic catalase and superoxide dismutase activities Additionally, there are studies that recommend supplementing with vitamin B3 niacin or a fibrate as suggested options for the correction of atherogenic dyslipidemia 13 , Extracts from fruits of the Citrus family, have been mentioned as lipid-lowering components, with statin-like effects More specifically, the use of hesperidin, a flavonoid compound abundantly occurring in Citrus family fruit peel, has been found to lower serum TG levels in hypertriglyceridemic subjects, possibly by reducing very low-density lipoprotein metabolic abnormalities In another study, conducted with the use of Citrus extracts and olive polyphenols, in relation to the lipid profile, there was a significant improvement in the serum levels of TC and LDL Due to the key antioxidant and anti-inflammatory effects of the plant extracts used in the composition of the nutritional supplement used herein along with vitamins B and chromium, a significant decrease in the TG levels was achieved. The main limitation of the present study was that the findings were obtained from a small group of individuals, as well as in its short duration. The results attained in the present study, even if these are derived from a small sample size, establish a tendency. Although the findings, particularly the suppressive effect on TG levels, appear promising, further larger studies for this nutritional supplement are required. Additionally, possible genetic profiling studies, related to the metabolism of TGs are required to further elucidate the regulatory mechanisms and the individual response after the use of a personalized intervention. Funding: The present study was funded by the National and Kapodistrian University of Athens research grands research grant no. ND and SB conceived the study. DK and CPT performed the patient medical examinations. EK, AT, SB and ND were involved in the acquisition of data, in the design of the study, and in the writing of the manuscript. VE performed the statistical analyses. All authors have read and approved the final manuscript. AT and VE confirm the authenticity of all the raw data. The other authors declare that they have no competing interests. Rader DJ, Hoeg JM and Brewer HB Jr: Quantitation of plasma apolipoproteins in the primary and secondary prevention of coronary artery disease. Ann Intern Med. Kopin L and Lowenstein CJ: Dyslipidemia. Berberich AJ and Hegele RA: A modern approach to dyslipidemia. Endocr Rev. A small arterial response to 0. Infusion of air causes a loss of endothelial function. Endothelial cell function is impaired by vascular loss of blood vessels in response to acetylcholine, and expansion in response to SNP remains intact. 내피세포가 부존재 하는 대동맥 고리는 2. 고농도의 칼륨이 혈관의 수축의 안정기 도달을 유발하였을 때, 대동맥 고리를 생리적식염수로 헹구었고, 30분 동안 재평형에 적용되었다. 혈관수축이 70 mM KCl에 의해 견고한 안정기에 도달한 후에 대동맥 고리는 30분 동안 생리적 식염수에 의해 안정화되었다. 이러한 반응은 세 번 반복되었고, 생리적 식염수로 안정화시킨 후에 노르에피네프린 norepinephrine, NE; 0. 혈관의 긴장은 30분 후에 안정상태에 도달하였다. 노르에피네프린은 0. Aortic rings without endothelial cells were applied to equilibrate for 90 minutes at 2. When high concentrations of potassium caused the plateau to reach the contraction of blood vessels, the aortic rings were rinsed with physiological saline and applied to rebalance for 30 minutes. After vasoconstriction reached a solid plateau with 70 mM KCl, the aortic rings were stabilized by physiological saline for 30 minutes. This response was repeated three times, and after stabilizing with physiological saline, the contractile response of the arteries to norepinephrine NE; 10 M at 0. Blood vessel tension reached a steady state after 30 minutes. Norepinephrine was added cumulatively from 0. 각 농도에서의 반응은 노르에피네피린의 다음 농도의 첨가 전에 평형에 도달하도록 하였다. 노르에피네프린에 의한 혈관 수축의 폭은 각 농도마다 측정하였다. The reaction at each concentration was allowed to reach equilibrium prior to the addition of the next concentration of norepinephrine. The width of vasoconstriction caused by norepinephrine was measured at each concentration. The effect of contraction with norepinephrine was expressed as a percentage of response to the maximum contracted by 70 mM KCl initially treated in each aorta. 모든 실험은 각각 4번에서 5번 반복되었다. All experiments were repeated four to five times each. 카르바콜 carbachol,CCh 처리 하에서 지연효과는 내피세포를 가진 대동맥 고리에서 조사되었다. 이러한 반응은 카르바콜로 세 번 반복되었고, 대동맥 고리는 내피세포의 존재 하에서 대동맥의 확장효과를 측정하기 위해서 70 mM KCl로 다시 수축시켰고, 0. 각각의 농도에 대한 반응은 카르바콜의 다음농도의 첨가 전에 안정기에 도달하도록 하였다. 카르바콜에 의해 유발된 지연 폭은 각각의 농도에서 측정되었다. 모든 실험은 각각 4~5번 반복되었다. The delayed effect under carbachol CCh treatment was investigated in the aortic rings with endothelial cells. After reaching a solid plateau of vasoconstriction induced by 70 mM KCl, the aortic rings were stabilized for 30 minutes by physiological saline. This reaction was repeated three times with carbacol, the aortic ring was retracted with 70 mM KCl to measure the aortic dilatation effect in the presence of endothelial cells and delayed carbacolo in a dose-dependent manner from 0. I was. The reaction for each concentration was allowed to reach a plateau before addition of the next concentration of carbacol. The delay width induced by carbacol was measured at each concentration. The delaying effect of contraction by carbacol was expressed as a percentage of response to maximum contracted by 70 mM KCl initially treated in each aorta where endothelial cells were present. All experiments were repeated times each. 혈관수축능력 및 이완능력에서도 당뇨군에서 정상군에 비해 혈관의 수축력이 월등 히 높았으며, 이완능력은 감소하여 혈관의 탄성도가 감소하였다. 그러나 상엽과 지각의 복합제 처리에 의해 혈관의 탄성도가 증가하여 당뇨로 인해서 나타나는 혈관부전 현상을 개선시키는 효과가 있음을 보였다. In diabetic group, diabetic group had significantly higher contractile force than diabetic group. However, it was shown that the elasticity of blood vessels was increased by the treatment of the upper lobe and the perceptual complex, thereby improving the vascular dysfunction caused by diabetes. 노르에피네프린 처리에 따른 혈관수축효과를 표 6 에 보인다. Table 6 shows the vasoconstriction effect of norepinephrine treatment. 카르바콜 처리에 따른 혈관수축의 지연효과를 표 7 에 보인다. Table 7 shows the delayed effect of vasoconstriction upon carbacol treatment. 본 발명에 따른 지각 또는 상엽 추출물은 물, 저급 알코올, 헥산, 에틸아세테이트 또는 이들의 혼합 용매로 추출할 수 있다. 더욱 바람직하게는, 유기용매를 이용하여 휘발성 혹은 비휘발성 물질을 분리하는 유기용매 추출법에 의해 제조될 수 있다. 이는 저급 알코올, 헥산, 에틸 아세테이트 또는 이들의 혼합 용매로 추출하는 단계 및 추출여액을 여과하여 농축하는 단계 및 동결 건조하는 단계로 구성된다. 상기 저급 알코올은 메탄올, 에탄올 및 부탄올로 이루어진 군으로부터 선택된다. 추출 과정으로는 냉침 추출법, 초음파 추출법, 여과법, 환류 추출법, 감압 농축법 등의 방법이 사용될 수 있으며, 이밖에도 통상적으로 사용되는 추출법이 사용될 수 있다. 또한, 지각 또는 상엽 추출물은 고온의 열수를 이용하여 가용성 물질들을 분리하는 열수추출법에 의해서도 제조될 수 있다. 농축 및 동결과정 또한 통상적으로 알려진 방법이 다양하게 사용될 수 있다. Crust or upper leaf extract according to the present invention can be extracted with water, lower alcohol, hexane, ethyl acetate or a mixed solvent thereof. More preferably, the organic solvent may be prepared by an organic solvent extraction method for separating volatile or nonvolatile materials. It consists of extracting with lower alcohol, hexane, ethyl acetate or a mixed solvent thereof, filtering the filtrate to concentrate and freeze drying. The lower alcohol is selected from the group consisting of methanol, ethanol and butanol. As the extraction process, methods such as cold needle extraction, ultrasonic extraction, filtration, reflux extraction, and vacuum concentration may be used. In addition, extraction methods commonly used may be used. In addition, the crust or upper leaf extract may also be prepared by hot water extraction to separate soluble substances using hot hot water. Concentration and freezing can also be used in a variety of commonly known methods. Japan 로 농축한 후, 동결 건조하여 본 발명의 원지 추출물을 제조하였다. 그 결과, 각각 지각 g 및 상엽 g의 건조추출물을 얻었다. for 1 hour, and the filtrate filtered with gauze was concentrated using a vacuum filter Eyela. Japan , followed by freeze drying. The raw paper extract of the invention was prepared. As a result, g of crust and g of upper leaf were obtained, respectively. Japan 로 농축한 후, 동결 건조하여 본 발명의 지각 또는 상엽 추출물을 제조하였다. 그 결과 지각 92g 및 상엽 98g의 건조추출물을 얻었다. The collected extract was filtered with filter paper, and the filtrate was concentrated in a reduced pressure filter Eyela. Japan at 45 ° C. and 1 atm, and then lyophilized to prepare the crust or upper leaf extract of the present invention. As a result, 92 g of crust and 98 g of upper leaf were obtained. 지각 또는 상엽 추출물의 인체 안정성을 검사하기 위하여 급성 독성실험을 하였다. 군당 5 마리씩의 동물에 본 발명의 지각 또는 상엽 추출물을 각각 0. 시험물질 투여 후 통상의 방법에 따라 동물의 폐사여부, 임상증상, 체중변화를 관찰하고 혈액학적 검사와 혈액 생화학적 검사를 실시하였으며, 부검하여 육안으로 복강장기와 흉강장기의 이상여부를 관찰하였다. Acute toxicity test was conducted to examine the human stability of the crust or upper leaf extract. Acute toxicity experiments were conducted using 6-week-old specific pathogen-free SPF SD mice. Five animals per group were suspended in 0. After administration of the test substance, the mortality, clinical symptoms, and weight change of the animals were observed according to the usual methods, and hematological and blood biochemical tests were performed. The necropsy was performed to visually observe the abdominal and thoracic organ abnormalities. 그 결과, 시험물질을 투여한 모든 동물에서 특기할 만한 임상증상이나 폐사된 동물은 없었으며, 체중변화, 혈액검사, 혈액생화학 검사, 부검소견 등에서도 독성변화는 관찰되지 않았다. As a result, no significant clinical symptoms or dead animals were noted in all animals treated with the test substance, and no toxic changes were observed in weight changes, blood tests, blood biochemical tests, and autopsy findings. Prepared using diluents or excipients. 경구 투여를 위한 고형 제제에는 정제, 환제, 산제, 과립제 및 캡슐제 등이 포함되며, 이러한 고형 제제는 원지 추출물에 적어도 하나 이상의 부형제 예를 들면, 전분, 탄산칼슘, 수크로오스 sucrose , 락토오스 및 젤라틴 등을 섞어 조제된다. 또한 단순한 부형제 이외에 스테아린산 마그네슘 Magnesium stearate , 탈크 talc 등과 같은 활택제들도 사용된다. Solid preparations for oral administration include tablets, pills, powders, granules, and capsules, and the like, which may be added to the original extract with at least one excipient such as starch, calcium carbonate, sucrose, lactose and gelatin. The mixture is prepared. In addition to simple excipients, glidants such as magnesium stearate, talc and the like are also used. 경구 투여를 위한 액상 제제로는 현탁제, 내용액제, 유제 및 시럽제 등이 해당되는데 흔히 사용되는 단순 희석제인 물, 리퀴드 파라핀 liquid paraffin 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제 및 보존제 등이 포함될 수 있다. Liquid preparations for oral administration include suspensions, solvents, emulsions, and syrups. In addition to the commonly used simple diluents, water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances and preservatives are available. And the like. 비경구 투여를 위한 제제에는 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조제제 및 좌제가 포함된다. 비수성용제와 현탁용제로는 프로필렌글리콜 propylene glycol , 폴리에틸렌글리콜 polyethylene glycol , 올리브 오일 olive oil 과 같은 식물성 기름, 에틸올레이트 ethyl oleate 와 같은 주사 가능한 에스테르 등이 사용 될 수 있다. 좌제의 기제로는 위텝솔 witepsol , 마크로골 macrogol , 트윈 tween 61, 카카오지, 라우린지, 글리세롤 및 젤라틴 등이 사용될 수 있다. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations and suppositories. Non-aqueous and suspending solvents may include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin, glycerol and gelatin may be used. 단, 특정 환자에 대한 투여용량 수준은 환자의 체중, 연령, 성별, 건강상태, 식이, 투여시간, 투여방법, 배설율, 질환의 중증도 등에 따라 변화될 수 있다. However, the dosage level for a particular patient may vary depending on the weight, age, sex, health status, diet, time of administration, administration method, excretion rate, severity of the disease, and the like of the patient. 본 발명의 추출물을 식품으로 사용할 경우, 상기 추출물을 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용되고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효 성분의 혼합양은 그의 사용 목적 예방, 건강 또는 치료적 처치 에 따라 적합하게 결정될 수 있다. 일반적으로, 본 발명의 추출물을 식품 또는 음료의 제조시에 원료에 대하여 0. 본 발명의 추출물의 유효용량은 상기 약학적 조성물의 유효용량에 준해서 사용할 수 있으나, 건강 및 위생을 목적으로 하거나 또는 건강 조절을 목적으로 하는 장기간의 섭취의 경우에는 상기 범위 이하일 수 있으며, 유효성분은 안전성 면에서 아무런 문제가 없기 때문에 상기 범위 이상의 양으로도 사용될 수 있음은 확실하다. 상기 물질을 첨가할 수 있는 식품의 예로는 육류, 소세지, 빵, 쵸코렛, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알콜 음료 및 비타민 복합제 등이 있으며, 보혈제, 보양제, 피부미백제 등을 목적으로 하는 민간 요법제 등을 들 수 있다. 또한, 삼소음패독산, 패독산, 오약순기삼 등과 같은 여러 한의학 처방들에도 사용할 수 있다. When the extract of the present invention is used as a food, the extract may be added as it is or used with other food or food ingredients, and may be appropriately used according to a conventional method. The blending amount of the active ingredient can be suitably determined according to the purpose of its use prevention, health or therapeutic treatment. In general, the extract of the present invention may be added in an amount of 0. An effective dose of the extract of the present invention may be used in accordance with the effective dose of the pharmaceutical composition, but may be less than the above range in the case of long-term intake for the purpose of health and hygiene or health control, Since there is no problem in terms of safety, it is certain that it can be used in an amount above the above range. Examples of the food to which the substance can be added include dairy products including meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, ice cream, various soups, drinks, tea, drinks, Alcoholic beverages and vitamin complexes; and folk remedies for the purpose of blood donors, nourishing agents, skin whitening agents and the like. In addition, it can be used in various oriental medicine prescriptions, such as Samsui paddok acid, paddok acid, five medicinal herbs. 실시예 6의 열수추출법에 따라 제조된 원지 추출물 0. Chewing gum was prepared using a conventional method using the composition of 0. 본 발명에서는 스트렙토조토신으로 당뇨병을 유발한 쥐에게 한약재인 지각을 투여한 결과, 당뇨병의 대표적 증상인 체중감소를 완화시켜주고, 혈당치를 현저히 낮추어 주는 효과를 처음으로 확인하고, 지각을 포함한 당뇨병 치료를 위한 약학적 조성물, 지각을 포함한 당뇨병 치료를 위한 식품 조성물 및 지각을 열수 추출하는 것을 특징으로 하는 당뇨병 치료제 제조방법을 제공한다. In the present invention, as a result of administering perception, which is a herbal medicine, to streptozotocin-induced rats, the first symptom of alleviating weight loss, which is a representative symptom of diabetes, and significantly lowering blood glucose levels, treating diabetes including perception It provides a pharmaceutical composition, a food composition for treating diabetes, including the perception, and a method for producing diabetes treatment, characterized in that the hot water extract perception. Payment date : Year of fee payment : 4. Year of fee payment : 5. |
| Comparison of Antidiabetic Activity of White Ginseng, Red Iris and Hwagi-sam in Induced Diabetic Rats, J. impossibility of application in pregnancy and during the suckling period , as well as their ineffectiveness in stemming the tissue complications that arise from long-term Type II diabetes. In rats VI who received a mixture of upper lobe and crust, the water intake was lower than that of V. Composition comprising the extracts of lysimachia clethroides for prevention and treatment of cardiovascular diseases. Ethics declarations Ethics approval and consent to participate The Institutional Review Board approved all testing procedures and protocols prior to beginning data collection 17— Participants read and sign an informed consent prior to participating in this study. Extracts of Eleutherococcus spp. Genetically Obese and Diabetic Mice Differ in How and in What Type of Polyunsaturated Fatty Acids are Accumulated in Tissues. |
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Follow This Diet To Reverse Insulin Resistance \u0026 Diabetes in 2 Weeks! Journal of Guilan University of Vlood Citrus aurantium for blood sugar balance Journal of Guilan University of Medical Sugat P. Box: Turmeric golden milk recipe, Iran. Email: medjour gums. Thu, Feb 15, فارسی [ Archive ]. Remember me Create Account Reset Password. Volume 15, Issue 57 JGUMS15 57 : Back to browse issues page. Citrus aurantium for blood sugar balance -
Overall, although the changes in the LDL levels are not deemed statistically significant, a tendency towards an improvement was observed in the results for TC, HDL and TG levels.
Median levels of TC, LDL, HDL and TGs at the beginning of the study and after 12 weeks of consumption of the supplement. TC, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TGs, triglycerides. The present open observational prospective study in individuals with mild hyperlipidemia, demonstrated that the nutritional supplement combining plant extracts from Citrus aurantium, Olea europaea leaf and Cistus creticus , administered for a period of 12 weeks, significantly reduced TG levels by The results are consistent with those of previous publications , in which the herbal extracts of the study supplement were studied separately.
In both studies, the doses of the extracts used were higher than those used in the present study. Since in the present study, the decrease in TG levels was considerably higher, yet with smaller doses, it can be assumed that this decrease may be attributed to the synergistic effect of the plant extracts.
High TG levels are considered a marker of high cholesterol levels in TG-rich lipoproteins, which are associated with low-grade inflammation Hypertriglyceridemia and high levels of TG-rich lipoproteins are considered an independent risk factor for atherosclerotic cardiovascular disease; therefore, any decrease in TG levels may have a beneficial effect on risk reduction.
In another study, fasting TG levels were shown to be associated with short- and long-term cardiovascular risk, even in individuals who were treated effectively with statins Additionally, from a multiple single nucleotide polymorphism Mendelian randomization analysis, the genetic findings support a casual effect of TGs on coronary heart disease events Increased levels of TGs are associated with increased levels of remnant cholesterol and with reduced levels of HDL-C On the other hand, HDL-C is important for the lipid transportation and metabolism, due to the removal of the excess cholesterol from peripheral tissues, but also for its anti-inflammatory and antioxidant properties 27 , 28 , attributed to the associated enzyme paraoxonase 1 PON1 PON1 binds to HDL-C and increases its antioxidant anti-atherogenic effects In the present study, a marked increase of 3.
Since it is widely accepted that HDL-C is critical due to its anti-atherogenic properties in mediating cholesterol transport from peripheral tissues to the liver 31 , an increase in HDL-C alongside with a significant decrease in TG levels appears to be beneficial for individuals with mild cardiovascular risk factors.
The blend of ingredients which was used in the present study, has been previously suggested to improve PON1 activity in parallel with an increase in HDL-C levels and a decrease in TG levels Moreover, supplementation with a water infusion of Cistus incanus also known as Cistus criticus 32 , has been demonstrated to exert antioxidant effects by significantly decreasing the malondialdehyde and advanced oxidative protein product concentrations in healthy volunteers Recently, Cistus incanus extract, through its potent antioxidant activity due to its high content of flavonoids, was proven to attenuate the negative effects of high fat-carbohydrates on erythrocytes in animal models It has also been demonstrated in vitro to have the ability to decrease the overproduction of reactive carbonyl species, particularly advanced glycation end products, which function as a prooxidant and pro-inflammatory agent in the organism Cistus creticus is considered to be an excellent source of natural antioxidants and the European Food Safety Authority included it in its scientific opinion In previous research, the administration of polyphenol-rich olive leaf extracts was found to significantly lower the serum levels of TC, TGs and LDL-C, and to increase the serum level of HDL-C.
These extracts were found to increase the serum antioxidant potential and the hepatic catalase and superoxide dismutase activities Additionally, there are studies that recommend supplementing with vitamin B3 niacin or a fibrate as suggested options for the correction of atherogenic dyslipidemia 13 , Extracts from fruits of the Citrus family, have been mentioned as lipid-lowering components, with statin-like effects More specifically, the use of hesperidin, a flavonoid compound abundantly occurring in Citrus family fruit peel, has been found to lower serum TG levels in hypertriglyceridemic subjects, possibly by reducing very low-density lipoprotein metabolic abnormalities In another study, conducted with the use of Citrus extracts and olive polyphenols, in relation to the lipid profile, there was a significant improvement in the serum levels of TC and LDL Due to the key antioxidant and anti-inflammatory effects of the plant extracts used in the composition of the nutritional supplement used herein along with vitamins B and chromium, a significant decrease in the TG levels was achieved.
The main limitation of the present study was that the findings were obtained from a small group of individuals, as well as in its short duration. The results attained in the present study, even if these are derived from a small sample size, establish a tendency.
Although the findings, particularly the suppressive effect on TG levels, appear promising, further larger studies for this nutritional supplement are required. Additionally, possible genetic profiling studies, related to the metabolism of TGs are required to further elucidate the regulatory mechanisms and the individual response after the use of a personalized intervention.
Funding: The present study was funded by the National and Kapodistrian University of Athens research grands research grant no. ND and SB conceived the study. DK and CPT performed the patient medical examinations. EK, AT, SB and ND were involved in the acquisition of data, in the design of the study, and in the writing of the manuscript.
VE performed the statistical analyses. All authors have read and approved the final manuscript. AT and VE confirm the authenticity of all the raw data.
The other authors declare that they have no competing interests. Rader DJ, Hoeg JM and Brewer HB Jr: Quantitation of plasma apolipoproteins in the primary and secondary prevention of coronary artery disease.
Ann Intern Med. Kopin L and Lowenstein CJ: Dyslipidemia. Berberich AJ and Hegele RA: A modern approach to dyslipidemia. Endocr Rev. Mascarenhas-Melo F, Sereno J, Teixeira-Lemos E, Marado D, Palavra F, Pinto R, Rocha-Pereira P, Teixeira F and Reis F: Implication of Low HDL-c levels in patients with average LDL-c Levels: A focus on oxidized LDL, Large HDL subpopulation, and adiponectin.
Mediators Inflamm. Khatana C, Saini NK, Chakrabarti S, Saini V, Sharma A, Saini RV and Saini AK: Mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis.
Oxid Med Cell Longev. Pei K, Gui T, Kan D, Feng H, Jin Y, Yang Y, Zhang Q, Du Z, Gai Z, Wu J and Li Y: An overview of lipid metabolism and nonalcoholic fatty liver disease. BioMed Res Int. Tarantino G, Balsano C, Santini SJ, Brienza G, Clemente I, Cosimini B and Sinatti G: It is high time physicians thought of natural products for alleviating NAFLD.
Is there sufficient evidence to use them? Int J Mol Sci. Tarantino G, Crocetto F, Di Vito C, Creta M, Martino R, Pandolfo SD, Pesce S, Napolitano L, Capone D and Imbimbo C: Association of NAFLD and insulin resistance with non metastatic bladder cancer patients: A cross-sectional retrospective study.
J Clin Med. Chou R, Dana T, Blazina I, Daeges M and Jeanne TL: Statins for prevention of cardiovascular disease in adults: Evidence report and systematic review for the US preventive services task force. Farnier M, Zeller M, Masson D and Cottin Y: Triglycerides and risk of atherosclerotic cardiovascular disease: An update.
Arch Cardiovasc Dis. Tenenbaum A and Fisman EZ: Fibrates are an essential part of modern anti-dyslipidemic arsenal: Spotlight on atherogenic dyslipidemia and residual risk reduction.
Cardiovasc Diabetol. Nordestgaard BG: Triglyceride-Rich lipoproteins and atherosclerotic cardiovascular disease: New insights from epidemiology, genetics, and biology.
Circ Res. Sando KR and Knight M: Nonstatin therapies for management of dyslipidemia: A review. Clin Ther. Widmer RJ, Flammer AJ, Lerman LO and Lerman A: The mediterranean diet, its components, and cardiovascular disease. Am J Med. Medina-Remón A, Casas R, Tressserra-Rimbau A, Ros E, Martínez-González MA, Fitó M, Corella D, Salas-Salvadó J, Lamuela-Raventos RM and Estruch R: PREDIMED Study Investigators.
Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: A substudy of the PREDIMED trial. Br J Clin Pharmacol. Annuzzi G, Bozzetto L, Costabile G, Giacco R, Mangione A, Anniballi G, Vitale M, Vetrani C, Cipriano P, Della Corte G, et al: Diets naturally rich in polyphenols improve fasting and postprandial dyslipidemia and reduce oxidative stress: A randomized controlled trial.
Am J Clin Nutr. Mazidi M, Katsiki N and Banach M: A greater flavonoid intake is associated with lower total and cause-specific mortality: A meta-analysis of cohort studies.
Email: medjour gums. Thu, Feb 15, فارسی [ Archive ]. Remember me Create Account Reset Password. Volume 15, Issue 57 JGUMS , 15 57 : Back to browse issues page. Download citation: BibTeX RIS EndNote Medlars ProCite Reference Manager RefWorks Send citation to:.
Ravanshad S, Naserollahzadeh J, Sovaid M, Setoudehmaram E. Effect of Sour Orange Citrus Aurantium L. Juice Consumption on Blood Glucose and Lipid Profile in Diabetic Patients with Dyslipidemia.
Abstract: Views. 당뇨병에 대한 기존의 인슐린이나 경구용 혈당 강하제의 투여로는 근원적 치료에 한계가 있기 때문에 최근에는 약물적 요법과 함께 다양한 생리활성을 갖고 있는 기능성 건강식품을 소재로한 당뇨병 예방 및 치료제로서의 가능성에 관한 연구가 시도되고 있으며 상당수의 환자들이 약물요법과 함께 운동요법과 민간요법을 시도하고 있는 것으로 나타났다 Lim, S.
The Effect of BuOH Fraction of Polygonatum odoratum with Selenium on Blood Glucose Level and Lipid Peroxidation in Streptozotocin Induced Diabetic Rats. Korean J. Nutrition, 33 7 Korean Soc. Food Sci. Nutrition, 33 7 : induced Diabetic Male Rats. 상엽 복합추출물과 운동의 병용이 스트렙토조토신 streptozotoin, STZ 에 의해 유 발된 당뇨의 혈액 내의 과산화지질의 양을 감소시킬 뿐만 아니라 간의 총 콜레스테롤의 저하에도 효과를 나타낸다고 보고 된 바 있으며 고영철, streptozotoin 당뇨 유발 흰쥐에서 상엽복합추출물과 운동이 지질대사에 미치는 영향, Korea Sport Research, , Vol.
It has been reported that the combination of lobe extract and exercise not only reduces the amount of lipid peroxide in the blood of diabetes induced by streptozotocin STZ , but also lowers the liver's total cholesterol Go Young Chul, streptozotoin.
The effect of upper lobe complex and exercise on lipid metabolism in diabetic rats, Korea Sport Research, , Vol. Antidiabetic Acupuncture Antioxidant Effect of Diet with Sea Tangle Extract, Korean Journal of Nutrition, , Vol.
또한, 백삼, 홍삼, 화기삼이 혈당강하 효과와 고혈당에 의한 체중 감소현상을 개선하며, 당뇨의 대표적인 증상인 다식과 다음 현상을 개선하였다는 보고가 있었고 박경수, 고성권, 정성현, Multiple Low Dose Streptozotoin 으로 유도된 당뇨 흰쥐에서 백삼, 홍상, 화기삼의 항당뇨 활성 비교, J. Ginseng Res. In addition, it has been reported that white ginseng, red ginseng, and Hwagi ginseng improve the hypoglycemic effect and weight loss caused by hyperglycemia, and improve the polymorphism and the following symptoms, which are the most common symptoms of diabetes Park, Kyoung Soo, Go Sung Kwon, Jung Sung Hyun, Multiple Low Dose Streptozotoin.
Comparison of Antidiabetic Activity of White Ginseng, Red Iris and Hwagi-sam in Induced Diabetic Rats, J. has been reported to be effective in inhibiting antioxidant obesity, diet, and prevention of diabetes Kim Jin-pyo, Jeon-ju, et al.
생약제를 이용한 당뇨병 치료용 조성물에 관한 특허로는 17 종의 주생약성분, 즉 동충하초, 우황, 서홍화, 황기, 수질, 호장근, 황정, 귀전우, 산수유, 목단피, 지골피, 구기자, 백출, 창출, 황련, 갈근 및 생지황을 함유하는 당뇨병 치료용 조성물에 관한 것 한국 특허등록번호 호 , 조개나물 Ajuga multiflora Bunge 로부터 혈당 강하작용이 강하고 안전성이 매우 높은 추출물을 저렴한 유기용매를 사용하여 간단하면서도 효과적으로 추출 정제하는 방법과 이 정제된 추출물을 약학적으로 사용가능한 부형제 또는 보조제 등과 함께 단독 또는 기타의 유효 약물들과 함께 병용해서 사용하는 당뇨병 치료제 조성물에 관한 것 한국 특허등록번호 호 , 순기산 생약 복합제 즉, 후박, 대황 및 지실의 추출물을 유효성분으로 함유하고 항당뇨 활성이 우수한 당뇨병 예방 및 치료용 조성물에 관한 것 한국 특허등록번호 호 및 황련, 인삼, 지모, 단삼에서 추출한 물질을 활성성분으로 하는 당뇨병 치료제인 한방약 복합제제에 관한 것 한국 특허등록번호 호 등이 있으나, 한약재 중에 지각을 첨가하였을 경우 이 당뇨병 치료에 상승 효과가 있다는 보고는 없었다.
Patents related to the composition for treating diabetes using herbal medicines include 17 kinds of main herbal ingredients, namely Cordyceps sinensis, cow sulfur, western safflower, astragalus, water quality, Ho Jang-geun, yellow jung, guinea cow, cornus milk, bark skin, phalanges, goji berry, baekchul, creation Of diabetes mellitus, a composition for treating diabetes, rhubarb, and green liquor Korean Patent Registration No.
Related to the antidiabetic composition used in combination with them Korean Patent Registration No. 본 발명자는 지각이 스트렙토조토신 streptozotoin, STZ 으로 유발한 당뇨 흰쥐의 혈당과 동맥혈관벽에 미치는 영향을 조사하여 지각이 당뇨병을 치료하는 효과가 있음을 최초로 밝히고 본 발명을 완성하였다. The present inventors first investigated the effects of perception on the blood glucose and arterial wall of diabetic rats induced with streptozotocin STZ and completed the present invention for the first time.
본 발명의 목적은, 지각이 혈관의 내피세포 보호기능을 나타내는 효과가 있고, 당뇨의 대표적인 증상인 체중감소와 다식현상을 개선시켜주며, 혈당을 낮추어 주고, 혈관의 탄성도를 증가시켜 당뇨로 인해서 나타나는 혈관부전현상을 개선시킬 수 있는 당뇨병 치료제, 건강보조식품 및 그 조제방법을 제공하고자 함에 있다.
An object of the present invention, the perception has the effect of showing the endothelial cell protective function of the blood vessels, improve the weight loss and polymorphism, which is a typical symptom of diabetes, lower blood sugar, increase the elasticity of the blood vessels due to diabetes An object of the present invention is to provide a therapeutic agent for diabetes, a dietary supplement, and a method for preparing the same, which may improve the vascular dysfunction.
상기와 같은 목적을 위하여 본 발명은 지각을 포함하는 당뇨병 치료를 위한 약학적 조성물을 제공한다. For this purpose, the present invention provides a pharmaceutical composition for treating diabetes comprising perception.
일반적으로 본 발명에 따른 당뇨병 치료용 조성물은 임상투여시에 경구 투여가 가능하며 일반적인 의약품 제제의 형태로 사용될 수 있다. 본 발명에 따른 당뇨병 치료용 조성물은 실제 임상투여시에 경구의 여러 가지 제형으로 투여될 수 있는데, 제제화 할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제된다. 경구투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 포함되며, 이러한 고형제제는 본 발명에 따른 항염증 조성물에 적어도 하나 이상의 부형제 예를 들면, 전분, 칼슘카보네이트 Calcium carbonate , 수크로스 Sucrose 또는 락토오스 Lactose , 젤라틴 등을 섞어 조제된다.
또한 단순한 부형제 이외에 마그네슘 스티레이트 탈크 같은 윤활제들도 사용된다. 경구를 위한 액상제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데 흔히 사용되는 단순희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제,보존제 등이 포함될 수 있다. In general, the composition for treating diabetes according to the present invention can be administered orally during clinical administration and can be used in the form of a general pharmaceutical preparation.
The composition for treating diabetes according to the present invention may be administered in various oral dosage forms during actual clinical administration, and when formulated, diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents, surfactants, etc.
Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and such solid preparations include at least one excipient such as starch, calcium carbonate in the anti-inflammatory composition according to the present invention.
Sucrose Sucrose or lactose Lactose , gelatin and the like are mixed and prepared. In addition to simple excipients, lubricants such as magnesium styrate talc are also used. Oral liquid preparations include suspending agents, liquid solutions, emulsions, and syrups, and may include various excipients, such as wetting agents, sweeteners, fragrances, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin.
보다 상세하게는 전체중량에 대하여 지각 추출물 4. More specifically, 4. It provides a pharmaceutical composition characterized by. It provides a pharmaceutical composition characterized in that the capsule is filled to contain. 본 발명의 제 2의 태양은 지각을 포함한 당뇨병 치료를 위한 식품 조성물에 관한 것이다. 본 발명에 따른 당뇨병 치료용 조성물을 식품으로 사용할 경우, 본 발명에 따른 당뇨병 치료용 조성물을 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용되고, 통상적인 방법에 따라 적절하게 사용될 수 있다.
상기 식품의 종류에는 특별한 제한은 없다. 상기 당뇨병 치료용 조성물을 첨가할 수 있는 식품의 예로는 각종 스프, 음료수, 차, 드링크제, 비타민 복합제, 츄잉껌, 아이스크림 및 소세지 등이 있고, 유효 성분의 혼합양은 그의 사용 목적 예방, 건강 또는 치료적 처치 에 따라 적합하게 결정될 수 있다. A second aspect of the present invention relates to a food composition for treating diabetes, including perception.
When the composition for treating diabetes according to the present invention is used as a food, the composition for treating diabetes according to the present invention may be added as it is or used together with other food or food ingredients, and may be appropriately used according to a conventional method.
There is no particular limitation on the kind of food. Examples of foods to which the composition for treating diabetes can be added include various soups, beverages, teas, drinks, vitamin complexes, chewing gums, ice creams and sausages, and the amount of the active ingredient is used for its purpose prevention, health or therapeutic treatment.
Can be suitably determined according to the treatment. 보다 상세하게는 지각 추출물 0. More specifically, crust extract 0. 아이스크림의 형태로는, 지각 추출물 0. In the form of ice cream, crust extract 0. 음료의 형태로는, 지각 추출물 0. In the form of a beverage, 0. 소세지의 형태로는,지각 추출물 0.
In the form of sausage, 0. 본 발명의 제 3의 태양은 지각으로부터 당뇨병 치료용 조성물을 제조하는 방법을 제공한다. 보다 상세하게는 지각을 열수 추출 또는 유기용매 추출하는 것을 특징으로 하는 당뇨병 치료제 제조방법을 제공한다. More specifically, the present invention provides a method for preparing diabetes treatment, characterized in that hot water extraction or organic solvent extraction from the crust.
여과기를 통해 여과하는 단계: 및 Filtration through filter: and. 상기 여액을 감압농축한 후, 동결 건조하는 단계를 포함하는 것을 특징으로 하는 당뇨병 치료제 제조방법을 제공한다. After concentrating the filtrate under reduced pressure, it provides a method for preparing a diabetes treatment comprising the step of freeze drying. 또한, 지각 건조물 분말 0.
초음파기로 5 내지 10분간 초음파처리하는 단계; Sonicating for 5 to 10 minutes with an ultrasonic wave;. 이하 본 발명을 실시예를 통하여 자세히 설명한다. 그러나 본 발명의 실시예는 본 발명의 권리범위를 한정하는 것이 아니며, 본 발명의 권리범위는 청구범위에 의하여 정하여진다. Hereinafter, the present invention will be described in detail through examples. However, embodiments of the present invention do not limit the scope of the present invention, the scope of the present invention is defined by the claims.
It measured using the MTT method and the results are shown in Table 1 and FIG. 그러나 세포는 스트렙토조토신에 의해서 생존율이 감소하였고, 지각과 스트렙토조토신을 함께 투여한 군 및 상엽과 스트렙토조토신을 함께 투여한 군에서의 혈관내피세포 생존율은 스트렙토조토신만을 투여한 군에 비하여 그 생존율이 증가하였다. 스트렙토조토신과 상엽 및 지각을 동시에 투여한 군에서 스트렙토조토신과 상엽만을 투여한 군보다 높은 세포 생존율을 보여서 지각이 혈관의 내피세포 보호기능 효과를 보였다.
There was no significant difference in the survival rate of vascular endothelial cells between normal group I , crust-treated group II , and upper lobe-administered group III. Survival rate increased to However, the survival rate of the cells was decreased by streptozotocin, and the survival rate of vascular endothelial cells in the group treated with the crust and streptozotocin, and the group treated with the upper lobe and streptozotocin was higher than that of the group treated with streptozotocin alone.
In the group treated with streptozotocin, upper lobe and perception simultaneously, the cell survival rate was higher than that of the group receiving only streptozotocin and upper lobe. 스트렙토조토신을 0.
체중, 음용수 섭취량은 전 실험 기간을 통해서 매일 일정한 시간에 측정하였다. Streptozotocin was dissolved in 0. Diabetes was considered higher than dL. Body weight and drinking water intake were measured at regular times every day throughout the entire experimental period. 수컷 스프레기-돌레이 쥐 Spraguee-Dawley rats, ~g 를 사용하였다.
사료와 물은 실험동안에 마음대로 섭취할 수 있도록 하였다. 동물의 보호와 취급은 기관의 지침의 최고 수준의 기준에 따라 하였다. Male Spraye-Dawley rats g were used. Feed and water were freely consumed during the experiment.
The care and handling of animals was in accordance with the highest standards of institutional guidelines. The animals were divided into 8 groups, with 15 of similar weights in a group. Group I was normal rat control group, II was perceptual treatment in normal rat, III was upper lobe treatment in normal rat, IV was upper lobe and perception in normal rat, and V was diabetes mellitus by streptozotocin.
Induced control group VI was treated with crust in diabetic rats, VII was treated with upper lobe in diabetic rats, and VIII was treated with a mixture of upper and crust in diabetic rats. 그룹 V에서 VIII은 하룻밤 동안 신선한 0. 스트렙토조토신 주입 3일 후에, 헤파린으로 응고가 방지된 모세혈관을 사용하여 의식이 있는 쥐의 눈 뒤 신경얼기로부터 retro-orbital plexus 혈액을 채취하였고, 포도당을 분석키트로 측정하였다.
Control rats Groups I II, III, IV were treated with tap water. Three days after streptozotocin injection, heparin-coagulated capillaries were used to collect blood from the retro-orbital plexus of conscious rats, and glucose was measured by analytical kits.
혼합물 처리는 스트렙토조토신 처리 12시간 전에 시작되었다. 쥐의 모든 그룹은 8주 동안의 기간동안 표준사육조건 하에 유지 되었고, 체중의 변화는 각각의 그룹에서 1주마다 기록하여, 평균을 계산하였다. Groups II and VI were orally administered with only perception, groups III and VII only with upper lobe, and groups IV and VIII with oral mixture of upper lobe and crust.
Mixture treatment was started 12 hours before streptozotocin treatment. All groups of rats were maintained under standard feeding conditions for a period of eight weeks, and changes in body weight were recorded every week in each group, and the mean was calculated.
지각이 당뇨병에 따른 체중감소 현상을 완화하는 효과를 가지고 있음을 확인하는 결과는 표 2 및 도 2 에 나타내었다. The results confirming that perception has an effect of alleviating weight loss due to diabetes are shown in Table 2 and FIG. IV gained a little more weight, but there was no significant increase, so there was no significant difference between them.
In the case of diabetes induced streptozotocin V , the body weight was significantly reduced compared to the other groups, and in the rats VI who received the perception of the diabetes-induced mice VI and the rats who received the upper lobe VII , the weight was decreased.
The symptoms were somewhat alleviated, and rats VI who received a mixture of upper lobe and perception in diabetic rats were significantly alleviated, indicating that the perception was effective in alleviating weight loss caused by diabetes.
실시예 2 에서와 같은 방법으로 정상쥐와 당뇨를 유발한 쥐를 그룹화하였다. Normal mice and diabetic rats were grouped in the same manner as in Example 2.
Experimental animals were collected from the abdominal aorta using a 22 gauge syringe under ether anesthesia and centrifuged at 4 ° C. 혈당은 글루코-테스터 Life Scan Inc.
A 로 매일 오전 시에 측정하였으며, 꼬리부위 혈관에서 란셋으로 채혈하였다. Blood glucose was measured daily at am with a gluco-tester Life Scan Inc. A , and blood was collected from the caudal vessel with lancet. 지각, 상엽 및 상엽과 지각의 혼합물의 투여방식과 사육조건은 실시예2 와 동일하 게 실시하였다. 혈액 내 혈당량은 1주 마다 모니터링하였다. The administration method and the breeding conditions of the crust, the upper leaf, and the mixture of the upper leaf and the crust were carried out in the same manner as in Example 2.
Blood glucose levels were monitored every week. Rats fasted overnight after 8 weeks were sacrificed by cardiac hemorrhage under light ether anesthesia, and for cardiac analysis, heparin was collected by cardiac puncture in a vial that prevented blood clotting with heparin.
Free format Herbal calorie-burning tonic : Mental focus and mindfulness meditation CASE. Year sugra fee payment : 4. Year of fee payment : 8. Effective date : In aurantiuum embodiment, the fraction is concentrated by freeze drying the supernatant. The fraction is useful to treat a disorder associated with abnormally elevated glucose levels in a subject by administering to the subject a therapeutically effective amount of the extract or a pharmaceutical composition containing the extract.
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