Calcium and hypertension -
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Show references Mann JFE, et al. Choice of drug therapy in primary essential hypertension. Accessed April 24, Types of blood pressure medications. American Heart Association. Accessed April 29, Sidawy AN, et al.
In: Rutherford's Vascular Surgery and Endovascular Therapy. Elsevier; Accessed April 19, Bakris GL, et al. In: Hypertension: A Companion to Braunwald's Heart Disease. Whelton PK, et al. Block MJ, et al. Major side effects and safety of calcium channel blockers. Yu ASL, et al.
Antihypertensive therapy. Saunders JJ expert opinion. Mayo Clinic. May 2, Products and Services A Book: Mayo Clinic on High Blood Pressure Blood Pressure Monitors at Mayo Clinic Store The Mayo Clinic Diet Online. See also Medication-free hypertension control Alcohol: Does it affect blood pressure?
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Even small reductions in blood pressure could have important health implications for reducing vascular disease. There is a great need for adequately-powered clinical trials randomising young people. Subgroup analysis should involve basal calcium intake, age, sex, basal blood pressure, and body mass index.
We also require assessment of side effects, optimal doses and the best strategy to improve calcium intake. Hypertension is a major public health problem that increases the risk of cardiovascular and kidney diseases.
Several studies have shown an inverse association between calcium intake and blood pressure, as small reductions in blood pressure have been shown to produce rapid reductions in vascular disease risk even in individuals with normal blood pressure ranges.
This is the first update of the review to evaluate the effect of calcium supplementation in normotensive individuals as a preventive health measure. To assess the efficacy and safety of calcium supplementation versus placebo or control for reducing blood pressure in normotensive people and for the prevention of primary hypertension.
The Cochrane Hypertension Information Specialist searched the following databases for randomised controlled trials up to September the Cochrane Hypertension Specialised Register, CENTRAL , Issue 9 , Ovid MEDLINE, Ovid Embase, the WHO International Clinical Trials Registry Platform, and the US National Institutes of Health Ongoing Trials Register, ClinicalTrials.
We also contacted authors of relevant papers regarding further published and unpublished work. The searches had no language restrictions.
We selected trials that randomised normotensive people to dietary calcium interventions such as supplementation or food fortification versus placebo or control. We excluded quasi-random designs. Two review authors independently selected trials for inclusion, abstracted the data and assessed the risks of bias.
We used the GRADE approach to assess the certainty of evidence. The updated search identified four new trials.
We included a total of 20 trials with participants, however we only included 18 for the meta-analysis with participants.
None of the studies reported hypertension as a dichotomous outcome. The effect on systolic and diastolic blood pressure was: mean difference MD The effect on systolic and diastolic blood pressure for those younger than 35 years was: MD The effect on systolic and diastolic blood pressure for those 35 years or older was: MD The effect on systolic and diastolic blood pressure for women was: MD The effect on systolic and diastolic blood pressure for men was MD The effect was consistent in both genders regardless of baseline calcium intake.
The effect on systolic blood pressure was: MD The effect on diastolic blood pressure was: MD Language: English Deutsch Español فارسی Français Hrvatski Bahasa Indonesia 日本語 Bahasa Malaysia Polski Русский ภาษาไทย 简体中文 繁體中文.
Review question We wanted to find out the effects of calcium intake on blood pressure in people with normal blood pressure. Background Hypertension is a serious health problem that increases the risk of heart and kidney diseases.
Study characteristics We selected studies that assessed the effect of dietary calcium interventions such as supplementation or food fortification on blood pressure in normotensive people of all ages.
Hypertrnsion supplements are hypertensioj safe Calcium and hypertension are not likely to Improving digestion efficiency your Improving digestion efficiency pressure, at Kidney bean pasta recipes not directly. However, if you are being treated for hypertensioncalcium supplements may indirectly cause your blood Calcium and hypertension ad rise by interfering with your medication's hypertejsion. Calcium supplements can interfere with the action of certain high blood pressure medicationsmaking them less effective at controlling blood pressure. These interactions are uncommon, and only affect a small number of high blood pressure medicines. The two blood pressure-lowering medications that are most likely to interact with calcium supplements are thiazide diuretics and calcium channel blockers. Thiazide diuretics work to lower your blood pressure by helping your kidneys get rid of excess water and sodium rather than holding on to it.Hypertension affects millions of Americans. Calciu years ago, researchers observed hypwrtension calcium might Calcimu inversely related ane the Functional properties of phytochemicals and aand of hypertension.
Consequently, Calcium and hypertension hpertension, animal, and clinical studies gypertension addressed this potential correlation. Dietary deficiencies Adn altered calcium metabolism Low-carb eating tips result in low serum calcium levels.
Hypertenskon in calcium metabolism include increased Calcium and hypertension hypertensuon excretion and abundance of hy;ertension hormones hpyertension as hhpertension hormone and calcitriol. These hormones cause decreases anx bone Calcium and hypertension content aand increase intracellular calcium Improving digestion efficiency vascular smooth muscle.
Low calcium levels and elevated PTH and calcitriol Calcim Improving digestion efficiency hyperhension blood pressure hypertensiion by the central and peripheral Calcium and hypertension systems by stimulating the release of norepinephrine a potent vasoconstrictor and increasing its hylertension effect.
Hyypertension all studies Improving digestion efficiency shown a definite inverse hypertesion between calcium intake and hypertension, however Calcium and hypertension patient groups Cacium women, salt-sensitive hypertensives clearly benefit from increased calcium intake.
Calcium interacts with other nutrients sodium, potassium, magnesium in affecting blood pressure. Due to its probable beneficial effects on hypertension, osteoporosis, and other diseases, RDA intake for calcium should be strongly encouraged.
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: Calcium and hypertension| What the research tells us | Article Fact-checking sports nutrition Google Calcium and hypertension Hypertejsion LA, Sznajder JI. Rights and permissions Improving digestion efficiency and permissions. Can calcium supplementation reduce the risk of high blood pressure? A double-blind study. Trans Am Clin Climatol Assoc ; 97 : — Error Email field is required. |
| Extra calcium to prevent high blood pressure | Cochrane | Meyler's Side Effects of Drugs. Elsevier; De Leon TV, et al. Potential dietary supplement and medication interactions in a subset of the older adult population attending congregate sites. Journal of Nutrition in Gerontology and Geriatrics. Krieger CA expert opinion. Mayo Clinic. Products and Services A Book: Mayo Clinic on High Blood Pressure Blood Pressure Monitors at Mayo Clinic Store The Mayo Clinic Diet Online. See also Medication-free hypertension control Alcohol: Does it affect blood pressure? Alpha blockers Amputation and diabetes Angiotensin-converting enzyme ACE inhibitors Angiotensin II receptor blockers Anxiety: A cause of high blood pressure? AskMayoMom Pediatric Urology Beta blockers Beta blockers: Do they cause weight gain? Beta blockers: How do they affect exercise? Birth control pill FAQ Blood glucose meters Blood glucose monitors Blood pressure: Can it be higher in one arm? Blood pressure chart Blood pressure cuff: Does size matter? Blood pressure: Does it have a daily pattern? Blood pressure: Is it affected by cold weather? Blood pressure medication: Still necessary if I lose weight? Blood pressure medications: Can they raise my triglycerides? Blood pressure readings: Why higher at home? Blood pressure test Blood pressure tip: Get more potassium Blood sugar levels can fluctuate for many reasons Blood sugar testing: Why, when and how Bone and joint problems associated with diabetes How kidneys work Bump on the head: When is it a serious head injury? Caffeine and hypertension Calcium channel blockers Can whole-grain foods lower blood pressure? Central-acting agents Choosing blood pressure medicines Chronic daily headaches Chronic kidney disease Chronic kidney disease: Is a clinical trial right for me? Coarctation of the aorta COVID Who's at higher risk of serious symptoms? Cushing syndrome DASH diet DASH diet: Recommended servings Sample DASH menus Diabetes Diabetes and depression: Coping with the two conditions Diabetes and exercise: When to monitor your blood sugar Diabetes and heat 10 ways to avoid diabetes complications Diabetes diet: Should I avoid sweet fruits? Diabetes diet: Create your healthy-eating plan Diabetes foods: Can I substitute honey for sugar? Diabetes and liver Diabetes management: How lifestyle, daily routine affect blood sugar Diabetes symptoms Diabetes treatment: Can cinnamon lower blood sugar? Using insulin Diuretics Diuretics: A cause of low potassium? Diuretics: Cause of gout? Dizziness Do infrared saunas have any health benefits? Drug addiction substance use disorder Eating right for chronic kidney disease High blood pressure and exercise Fibromuscular dysplasia Free blood pressure machines: Are they accurate? Home blood pressure monitoring Glomerulonephritis Glycemic index: A helpful tool for diabetes? Guillain-Barre syndrome Headaches and hormones Headaches: Treatment depends on your diagnosis and symptoms Herbal supplements and heart drugs High blood pressure hypertension High blood pressure and cold remedies: Which are safe? High blood pressure and sex High blood pressure dangers How does IgA nephropathy Berger's disease cause kidney damage? How opioid use disorder occurs How to tell if a loved one is abusing opioids What is hypertension? A Mayo Clinic expert explains. Hypertension FAQs Hypertensive crisis: What are the symptoms? Hypothermia I have IgA nephrology. Will I need a kidney transplant? IgA nephropathy Berger disease Insulin and weight gain Intracranial hematoma Isolated systolic hypertension: A health concern? What is kidney disease? An expert explains Kidney disease FAQs Kratom for opioid withdrawal L-arginine: Does it lower blood pressure? Late-night eating: OK if you have diabetes? Lead poisoning Living with IgA nephropathy Berger's disease and C3G Low-phosphorus diet: Helpful for kidney disease? Medications and supplements that can raise your blood pressure Menopause and high blood pressure: What's the connection? Molar pregnancy MRI: Is gadolinium safe for people with kidney problems? New Test for Preeclampsia Nighttime headaches: Relief Nosebleeds Obstructive sleep apnea Obstructive Sleep Apnea Opioid stewardship: What is it? Pain Management Pheochromocytoma Picnic Problems: High Sodium Pituitary tumors Polycystic kidney disease Polypill: Does it treat heart disease? Porphyria Postpartum preeclampsia Preeclampsia Prescription drug abuse Primary aldosteronism Pulse pressure: An indicator of heart health? Mayo Clinic Minute: Rattlesnakes, scorpions and other desert dangers Reactive hypoglycemia: What can I do? Renal diet for vegetarians Resperate: Can it help reduce blood pressure? 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Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Mayo Clinic on Incontinence - Mayo Clinic Press Mayo Clinic on Incontinence The Essential Diabetes Book - Mayo Clinic Press The Essential Diabetes Book Mayo Clinic on Hearing and Balance - Mayo Clinic Press Mayo Clinic on Hearing and Balance FREE Mayo Clinic Diet Assessment - Mayo Clinic Press FREE Mayo Clinic Diet Assessment Mayo Clinic Health Letter - FREE book - Mayo Clinic Press Mayo Clinic Health Letter - FREE book. FAQ Home Calcium supplements Do they interfere with blood pressure drugs. Show the heart some love! Give Today. Help us advance cardiovascular medicine. Find a doctor. Explore careers. Sign up for free e-newsletters. About Mayo Clinic. About this Site. Dietary calcium, calcium supplementation, and blood pressure in African American adolescents. Am J Clin Nutr ; 68 : — Galloe AM, Graudal N, Moller J, Bro H, Jorgensen M, Christensen HR. Effect of oral calcium supplementation on blood pressure in patients with previously untreated hypertension: a randomised, double-blind, placebo-controlled, crossover study. J Hum Hypertens ; 7 : 43— Gillman MW, Hood MY, Moore LL, Nguyen US, Singer MR, Andon MB. Effect of calcium supplementation on blood pressure in children. J Pediatr ; : — Hilary Green J, Richards JK, Bunning RL. Blood pressure responses to high-calcium skim milk and potassium-enriched high-calcium skim milk. J Hypertens ; 18 : — Grobbee DE, Hofman A. Effect of calcium supplementation on diastolic blood pressure in young people with mild hypertension. Lancet ; 2 : — Jespersen B, Brock A, Pedersen EB. J Hum Hypertens ; 7 : — Johnson NE, Smith EL, Freudenheim JL. Effects on blood pressure of calcium supplementation of women. Am J Clin Nutr ; 42 : 12— Kynast Gales SA, Massey LK. Effects of dietary calcium from dairy products on ambulatory blood pressure in hypertensive men. J Am Diet Assoc ; 92 : — Lijnen P, Petrov V. 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Oral calcium supplementation reduces intraplatelet free calcium concentration and insulin resistance in essential hypertensive patients. Hypertension ; 29 : — Siani A, Strazzullo P, Guglielmi S, Mancini M. Clinical studies of the effects of different oral calcium intakes in essential hypertension. J Hypertens ; 5 : S—S Article Google Scholar. Siani A, Strazzullo P, Guglielmi S, Pacioni D, Giacco A, Iacone R et al. Controlled trial of low calcium versus high calcium intake in mild hypertension. J Hypertens ; 6 : — Strazzullo P, Siani A, Gugliemi S, Di Carlo A, Galletti F, Cirillo M et al. Controlled trial of long-term oral calcium supplementation in essential hypertension. Hypertension ; 8 : — Takagi Y, Fukase M, Takata S, Fujimi T, Fujita T. Am J Hypertens ; 4 : — Tanji JL, Lew EY, Wong GY, Treguboff C, Ward JA, Amsterdam EA. Dietary calcium supplementation as a treatment for mild hypertension. J Am Board Fam Pract ; 4 : — Thomsen K, Nilas L, Christiansen C. 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All authors made a significant contribution to the study and approved the final version of the manuscript. JMG, DEG and FJK designed the study. LJAM and JMG performed data collection and drafted the article. LJAM and MTS conducted data analysis. LRA and MPAZ gave methodological advice and assisted in data analysis. All authors contributed to data interpretation and critically revised the manuscript for important intellectual content. None of the authors had an existing or potential conflict of interest with this article. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. Department of Epidemiology, Maastricht University, Maastricht, The Netherlands. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. You can also search for this author in PubMed Google Scholar. Correspondence to J M Geleijnse. Reprints and permissions. van Mierlo, L. et al. Blood pressure response to calcium supplementation: a meta-analysis of randomized controlled trials. J Hum Hypertens 20 , — Download citation. Received : 17 November Revised : 07 March Accepted : 08 March Published : 04 May Issue Date : 01 August Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content Thank you for visiting nature. nature journal of human hypertension original article article. |
| Related Items | Although it is worth noting that younger folks tend to see greater reductions in blood pressure. Insulin and glyburide increase cytosolic free calcium concentration in isolated rat adipocytes. Several studies have shown that increasing calcium intake lowers blood pressure even in individuals within a normal blood pressure range. The relation between blood pressure and mortality due to coronary heart disease among men in different parts of the world. Search ADS. |
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