Category: Diet

Polyphenols and weight management

Polyphenols and weight management

Ibero-Baraibar I, Perez-Cornago Weigyt, Ramirez MJ, Martínez JA, Zulet Polypyenols. Figure 2. Manatement to Forskolin and scientific research Fast muscle soreness relief. Scand J Med Self-esteem Sport. Nat Rev Neurosci. Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease. The abdominal fat depots were assessed at two time points, baseline and 18 months thereafter, using 3-T MRI Philips Ingenia 3.

Polyphenols and weight management -

As a result, there are anti-inflammatory interleukins, nitric oxide NO and hydrogen sulfite H 2 S being produced, which will provide the resolution and tissue regeneration. Products from polyphenols metabolization are also connected with this anti-inflammatory pathway to several organs in the body.

M1, type 1 macrophages; M2, type 2 macrophages; IL, interleukin; TNF-α, tumor necrosis factor-alpha. Green lines mean resolution of the inflammatory process and red lines mean the uncontrolled inflammatory process leading to an inflammatory cascade.

In the liver, PUFAs are metabolized and converted into prostaglandins PGE2 and leukotrienes, which reach the inflammation site being converted into lipoxins, resolvins, protectins, and maresins, which will stimulate type 2 macrophages more so than the type 1 kind, leading to the production of anti- inflammatory interleukins , Likewise, polyphenols are absorbed in the intestine after being hydrolyzed by intestine enzymes and the host's microbiota Then, the resulting molecules can interact with free radicals and inhibit enzymes involved in the AA pathway, modulating the inflammatory response and blocking the AA pathway Besides that, endothelial cells are also being stimulated by both products from polyphenols and ω-3 PUFAs metabolization to produce NO and H 2 S in the first case, which will aid the resolution of the inflammatory situation and the tissue regeneration, or trigger signaling cascades by interacting with cell membrane receptors such as vascular endothelial growth factor VEGF or blocking p-AKT, NF-κB, and MMP-9 activities , The mechanisms involved in balancing the inflammatory process are the change of the phospholipid fatty acid composition of the cell membrane, inhibition of the NF-κβ activation, thus reducing the expression of pro-inflammatory genes and production of resolving mediators by macrophages Choosing daily healthy food type intake is the chief component and managed by humans to improve their own and all family healthy lifestyle Among the several factors of healthy lifestyle or prevalence of obesity and its RMDs can be associated with regular or irregularly and healthy or unhealthy daily food consumed in each meal 22 , In addition, it may also be associated with the lower purchase price of unhealthy foods on the market compared with healthy ones, whose edible parts leaves, peel, flesh, seeds, and others are wasted in homes, restaurants and other food enterprises due to their lack of nutritional knowledge , In addition, also it is known that refined sugar is often always added to edible vegetables, fruits, natural juices and other by-products and other beverages, which can be associated with obesity, overweight, CVD, and other metabolic diseases prevalence Thereby, Figure 4 summarizes food types that improve healthy life green line , which oil rich in ω-3 PUFAs, oleic acid and short-chain fatty acid are widely recommended 4.

Figure 4. Healthy food green line intake reduce obesity to normal conditions, while unhealthy food red line conduces to obesity and its related metabolic diseases. Paradoxically, nowadays, meals rich in vegetables and fruits are associated with poor and traditional peoples, while meat and sweetened ones are associated with rich and modern life 24 , , The consumption of foods marked by the red line Figure 4 must be reduced, because they are sweetened and fatted, including long-chain saturated fatty acids mainly myristic and palmitic acids , ω-6 PUFAs and industrialized trans-fatty acids present high amounts of calories in their composition, which are primarily associated with obesity and its prevalent RDMs Hence, for human behavior changes, joint activities between Universities, Research Centers, Health Ministries, and others will be legally necessary constitution of Departments that could be responsible by outline joint projects and approaches for health promotion through seminars, and lectures to implement in schools Primary and Secondary , enterprises and families to promote healthy food cooking, sale, and intake to pave the way to reduce obesity and its RMDs prevalence — Thus, for behavior change, it is necessary to draw out a joint projects of research institutions and the Health Ministries to schools, enterprises and families to promote healthy food intake to reduce obesity and its related metabolic diseases.

TS, DM, VZ-P, DB, AP, and RG conceptualized the topic, researched and analyzed the literature, wrote the manuscript, and including interpretation.

PF, GM, PH, MV, RF, EC, and VN contributed with draft and interpretation and revised the manuscript critically for intellectual content. All authors have read and approved the final version of the manuscript, ensure the accuracy and integrity of the work, and agree to be accountable for all appearance.

This study was financed in part by the CAPES-finance code The study was also supported by research grants from the National Council for Scientific and Technological Development Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. We thank the Graduate Program in Material Sciences, Graduate Program in Biotechnology and Biodiversity, and the Graduate Program in Health and Development in the Central-West Region, Federal University of Mato Grosso do Sul-UFMS for support.

Rogero MM, Calder P. Obesity, inflammation, toll-like receptor 4 and fatty acids. doi: PubMed Abstract CrossRef Full Text Google Scholar.

Lyons CL, Kennedy EB, Roche HM. Metabolic inflammation-differential modulation by dietary constituents. Figueiredo PS, Inada AC, Marcelino G, Cardozo CML, Freitas KC, Guimarães RCA, et al.

Fatty acids consumption: the role metabolic aspects involved in obesity and its associated disorders. Machate DJ, Figueiredo PS, Marcelino G, Guimarães RCA, Hiane PA, Bogo D, et al.

Fatty acid diets: regulation of gut microbiota composition and obesity and its related metabolic dysbiosis. Int J Mol Sci. World Health Organization. Health Diet. Google Scholar. Mafort TT, Rufino R, Costa CH, Lopes AJ.

Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function. Multidiscip Respir Med. Kris-Etherton PM, Grieger JA, Etherton TD. Dietary reference intakes for DHA and EPA.

Prostaglandins Leukot Essent Fatty Acids. Slavin JL, Lloyd B. Health benefits of fruits and vegetables. Adv Nutr. Hogan S, Canning C, Sun S, Sun X, Zhou K. Effects of grape pomace antioxidant extract on oxidative stress and inflammation in diet induced obese mice.

J Agric Food Chem. Van Hul M, Geurts L, Plovier H, Druart C, Everard A, Stahlman M, et al. Reduced obesity, diabetes, and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier.

Am J Physiol Endocrinol Metab. Violi F, Loffredo L, Pigatelli P, Angelico F, Bartimoccia S, Nocella C, et al. Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects.

Nutr Diabetes. Carnevale R, Loffredo L, Del Ben M, Angelico F, Nocella C, Petruccioli A, et al. Extra virgin olive oil improves post-prandial glycemic and lipid profile in patients with impaired fasting glucose. Clin Nutr.

Chuang CC, McIntosh MK. Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases. Annu Rev Nutr. Méndez L, Medina I. Polyphenols and fish oils for improving metabolic health: a revision of the recent evidence for their combined nutraceutical effects.

Pagliaro M, Pizzone DM, Scurria A, Lino C, Paone E, Mauriello F, et al. Sustainably sourced olive polyphenols and ômega-3 marine lipids: a synergy fostering public health.

ACS Food Sci Technol. CrossRef Full Text Google Scholar. Pan H, Gao Y, Tu Y. Mechanisms of body weight reduction by black tea polyphenols. Manach C, Mazur A, Scalbert A. Polyphenols and prevention of cardiovascular diseases.

Curr Opin Lipidol. Hodgson JM, Croft KD. Tea flavonoids and cardiovascular health. Mol Aspects Med. Cheng YC, Sheen JM, Hu WL, Hung YC. Polyphenols and oxidative stress in atherosclerosis-related ischemic heart disease and stroke.

Oxid Med Cell Longev. Giglio RV, Patti AM, Cicero AFG, Luppi G, Rizzo M, Toth PP, et al. Polyphenols: potential use in the prevention and treatment of cardiovascular diseases.

Curr Pharm Des. Tang GY, Meng X, Gan RY, Zhao CN, Liu Q, Feng YB, et al. Health functions and related molecular mechanisms of tea components: an update review. Laraia BA, Leak TM, Tester JM, Leung CW. Biobehavioral factors that shape nutritional in low-income populations: a narrative review.

Am J Prev Med. Jones NRV, Conklin AI, Suhrcke M, Monsivais P. The growing price gap between more and less healthy foods: analysis of a novel longitudinal UK dataset. PLoS ONE. Seguin R, Connor L, Nelson M, LaCroix A, Eldridge G. Understanding barriers and facilitators to healthy eating and active living in rural communities.

J Nutr Metab. Fard NA, Morales GF, Mejova Y, Schifanella R. On the interplay between educational attainment and nutrition: a spatially-aware perspective. EPJ Data Sci. Zhu F, Du B, Zheng L, Li J. Advance on the bioactivity and potential applications of dietary fibre from grape pomace.

Food Chem. Ribeiro LF, Ribani RH, Francisco TMG, Soares AA, Pontarolo R, Haminiuk CWI. Profile of bioactive compounds from grape pomace Vitis vinifera and Vitis labrusca by spectrophotometric, chromatographic and spectral analyses.

J Chromatogr B Analyt Technol Biomed Life Sci. Rasines-Perea Z, Teissedre PL. Grape polyphenols' effects in human cardiovascular diseases and diabetes. Talhaoui N, Gómez-Caravaca AM, León L, De la Rosa R, Fernández-Gutiérrez A, Segura-Carretero A.

From olive fruits to olive oil: phenolic compound transfer in six different olive cultivars grown under the same agronomical conditions.

Dal S, Sigrist S. The protective effect of antioxidants consumption on diabetes and vascular complications. Lamien-Meda A, Lamien CE, Compaoré MMY, Meda RNT, Kiendrebeogo M, Zeba B, et al. Polyphenol content and antioxidant activity of fourteen wild edible fruits from Burkina Faso.

Shan S, Huang X, Shah MH, Abbasi AM. Evaluation of polyphenolics content and antioxidant activity in edible wild fruits. Biomed Res Int. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Kumar V, Sharma A, Kohli SK, Bali S, Sharma M, Kumar R, et al.

Differential distribution of polyphenols in plants using multivariate techniques. Biotechnol Res Innov. Serreli G, Deiana M. Biological relevance of extra virgin olive oil polyphenols metabolites.

Lima GPP, Vianello F, Corrêa CR, Campos RAS, Borguini MG. Polyphenols in fruits and vegetables and its effect on human health. Food Nutr Sci. Xu DP, Li Y, Meng X, Zhou T, Zhou Y, Zheng J, et al.

Natural antioxidants in foods and medicinal plants: Extraction, assessment and resources. Wei Z, Luo J, Huang Y, Guo W, Zhang Y, Guan H, et al. Profile of polyphenol compounds of five muscadine grapes cultivated in the United States and in newly adapted locations in China. Liu C, Guo Y, Sun L, Lai X, Li Q, Zhang W, et al.

Six types of tea reduce high-fat diet-induced fat accumulation in mice by increasing lipid metabolism and suppressing inflammation. Food Funct. Chuang CC, Shen W, Chen H, Xie G, Jia W, Chung S, et al.

Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice. Pascual-Serrano A, Arola-Arnal A, Suárez-García S, Bravo FI, Suárez M, Arola L, et al.

Grape seed proanthocyanidin supplementation reduces adipocyte size and increases adipocyte number in obese rats. Int J Obes. Elmhdwi MF, Elaali NMS, Mohamed NN, Muktar MA, Buzgeia NB. Anti-diabetic activity of methanolic extract of grape seeds in alloxan induced diabetic rats.

Agr Res Tech. Ballard CR, Santos EF, Dubois MJ, Pilon G, Cazarin CBB, Maróstica Junior MR, et al. Two polyphenol-rich Brazilian fruit extracts protect from diet-induced obesity and hepatic steatosis in mice.

Ebaid H, Bashandy SAE, Alhazza IM, Hassan I, Al-Tamimi J. Efficacy of a methanolic extract of Adansonia digitata leaf in alleviating hyperglycemia, hyperlipidemia, and oxidative stress of diabetic rats. Vazquez A, Sanchez-Rodriguez E, Vargas F, Montoro-Molina S, Romero M, Espejo-Calvo JA, et al.

Cardioprotective effect of a virgin olive oil enriched with bioactive compounds in spontaneously hypertensive rats. Jurado-Ruiz E, Álvarez-Amor L, Varela LM, Bern á G, Parra-Camacho MS, Oliveira-Lopez MJ, et al. Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice.

Sci Rep. Weisberg SP, Leibel R, Tortoriello DV. Dietary curcumin significantly improves obesity- associated inflammation and diabetes in mouse models of diabesity. Seo KI, Lee J, Choi RY, Lee HI, Lee JH, Jeong YK, et al.

Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice. Oliveira PR, Costa CA, Bem GF, Cordeiro VSC, Santos IB, Carvalho LCRM, et al.

Euterpe oleracea Mart. Panchal SK, Poudyal H, Waanders J, Brown L. Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats.

J Nutr. Body lean mass was not affected by green tea during PA treatment 41 , One study also reported no influence in exercise performance by considering the changes of oxygen consumption peak VO 2 It is suggested that the improvement of exercise performance by green tea could be attributed, at least partly, to muscle glycogen sparing due to the stimulation of whole-body fat utilization Therefore, this approach have been followed in physically fit subjects and showing an increase of whole-body fat utilization Resveratrol is a stilbene present in the skin of grapes, blueberries, raspberries as well as wine that can improve the metabolic syndrome However, these results 70 presented a large heterogeneity regarding dosage and duration.

Thus, further studies with established doses are warranted for a better comprehension of the anti-obesity potential of resveratrol. Although, weight and fat loss did not reach statistically significance in the Faghihzadeh et al. Indeed, the current evidence is mostly supportive for the potential liver and cardio-protective effects of resveratrol Our review has some strengths.

Firstly, this is the first review summarizing the additional effects of polyphenol supplementation in addition to a conventional obesity therapy CRD and PA. Secondly, we did not restrict the study selection regarding the gender of participants, their health status, ethnicity, and type of polyphenol supplemented.

We considered these differences during the interpretation of the results and a comprehensive understanding of the overall evidence was reached. However, some limitation should be also considered.

The number of eligible and selected studies was small. Non-English studies were excluded, so we probably missed few studies, especially some Asian RCTs. Furthermore, the body composition parameters were not primary outcomes in all the included RCTs, and therefore, some data was missing.

Due to incomplete data and the small number of studies, it was not feasible to perform a meta-analysis. Moreover, the included studies also presented some methodological drawbacks. Generally, they had a short duration, so the prolonged effects of polyphenols remain unclear.

The small number of participants in most of the studies caused a low statistical power to identify significant differences. The compliance to polyphenol intake among the participants was uncertain in several of the studies.

Only two RCTs 32 , 39 measured it by plasma or urine metabolites, five RCTs counted the consumed containers 26 , 34 , 36 , 42 , 43 and eight did not report anything. Diet and PA outside the study protocol was not controlled in the majority of the RCTs.

Moreover, some bias was detected regarding the randomization process, blindness and the missing outcome data bias. The methodological drawbacks should be considered by future researchers to minimize or avoid them. Findings from this review also suggest that the effects of polyphenols in metabolic parameters might be stronger in patients with already cardiometabolic diseases.

Based on the current evidence, the anti-obesity potential of CRD and PA was not improved by adding other types of polyphenols. There is some evidence suggesting that polyphenols may be more effective in weight maintenance rather than inducing weight loss.

Moreover, new RCTs should also focus on investigating the plausible implicated pathways to obesity, such as energy expenditure, fat metabolism, and appetite. FL and RZ-R contributed to conception and design, screening of the article, data extraction and assessing the quality of the studies.

FL wrote the first draft and RZ-R critically revised and edited the manuscript. Both authors read and approved the final manuscript. ERDF, a way to build Europe.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

RCT, randomized clinical trial; CRD, calorie restricted diet; PA, physical activity; CRD-PP, calorie restricted diet plus polyphenol supplementation; PA-PP, physical activity plus polyphenol supplementation; WC, waist circumference.

Swift DL, Houmard JA, Slentz CA, Kraus WE. Effects of aerobic training with and without weight loss on insulin sensitivity and lipids. PLoS ONE. doi: PubMed Abstract CrossRef Full Text Google Scholar.

Weiss EP, Albert SG, Reeds DN, Kress KS, Mcdaniel JL, Klein S, et al. Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial 1.

Am J Clin Nutr. CrossRef Full Text Google Scholar. Swift DL, Johannsen NM, Lavie CJ, Earnest CP, Blair SN, Church TS. Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations.

Borrell LN, Samuel L. Body mass index categories and mortality risk in US adults: The effect of overweight and obesity on advancing death. Am J Public Health. Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. Greenway FL. Physiological adaptations to weight loss and factors favouring weight regain.

Int J Obes. King NA, Caudwell P, Hopkins M, Byrne NM, Colley R, Hills AP, et al. Narayanaswami V, Dwoskin LP. Obesity: Current and potential pharmacotherapeutics and targets. Pharmacol Ther. Neff KJ, Olbers T, le Roux CW. Bariatric surgery: the challenges with candidate selection, individualizing treatment and clinical outcomes.

BMC Med. World Health Organization. Obesity and Overweight. Google Scholar. Zamora-Ros R, Guinó E, Henar Alonso M, Vidal C, Barenys M, Soriano A, et al. Dietary flavonoids, lignans and colorectal cancer prognosis.

Sci Rep. Zamora-Ros R, Touillaud M, Rothwell JA, Romieu I, Scalbert A. Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: Current tools and applications and their limits. Guo X, Tresserra-Rimbau A, Estruch R, Martínez-González MA, Medina-Remón A, Fitó M, et al.

Polyphenol levels are inversely correlated with body weight and obesity in an elderly population after 5 years of follow up The randomised PREDIMED study.

Jennings A, MacGregor A, Spector T, Cassidy A. Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: Evidence from discordant monozygotic twins.

Mu Y, Kou T, Wei B, Lu X, Liu J, Tian H, et al. Soy products ameliorate obesity-related anthropometric indicators in overweight or obese asian and non-menopausal women: A meta-analysis of randomized controlled trials. Gheflati A, Mohammadi M, Ramezani-Jolfaie N, Heidari Z, Salehi-Abargouei A, Nadjarzadeh A.

Does pomegranate consumption affect weight and body composition? A systematic review and meta-analysis of randomized controlled clinical trials. Phyther Res. Farhat G, Drummond S, Al-Dujaili EAS. Polyphenols and their role in obesity management: a systematic review of randomized clinical trials.

Achten J, Jeukendrup AE. Optimizing fat oxidation through exercise and diet. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing h energy expenditure and fat oxidation in humans.

Min SY, Yang H, Seo SG, Shin SH, Chung MY, Kim J, et al. Cocoa polyphenols suppress adipogenesis in vitro and obesity in vivo by targeting insulin receptor. Rupasinghe HPV, Sekhon-Loodu S, Mantso T, Panayiotidis MI.

Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss. Boix-Castejón M, Herranz-López M, Pérez Gago A, Olivares-Vicente M, Caturla N, Roche E, et al. Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: A randomized controlled trial.

Food Funct. Murase T, Haramizu S, Shimotoyodome A, Tokimitsu I. Reduction of diet-induced obesity by a combination of tea-catechin intake and regular swimming.

Lambert K, Hokayem M, Thomas C, Fabre O, Cassan C, Bourret A, et al. Combination of nutritional polyphenols supplementation with exercise training counteracts insulin resistance and improves endurance in high-fat diet-induced obese rats. Shimotoyodome A, Haramizu S, Inaba M, Murase T, Tokimitsu I.

Exercise and green tea extract stimulate fat oxidation and prevent obesity in mice. Med Sci Sports Exerc.

Barsalani R, Riesco E, Lavoie JM, Dionne IJ. Effect of exercise training and isoflavones on hepatic steatosis in overweight postmenopausal women. Llaneza P, González C, Fernández-Iñarrea J, Alonso A, Díaz F, Pérez-López FR.

Soy isoflavones improve insulin sensitivity without changing serum leptin among postmenopausal women. Choquette S, Riesco É, Cormier É, Dion T, Aubertin-Leheudre M, Dionne IJ. Effects of soya isoflavones and exercise on body composition and clinical risk factors of cardiovascular diseases in overweight postmenopausal women: A 6-month double-blind controlled trial.

Br J Nutr. Natsume M, Osakabe N, Oyama M, Sasaki M, Baba S, Nakamura Y, et al. Structures of - -epicatechin glucuronide identified from plasma and urine after oral ingestion of - -epicatechin: differences between human and rat.

Free Radic Biol Med. Kord-Varkaneh H, Ghaedi E, Nazary-Vanani A, Mohammadi H, Shab-Bidar S. A systematic review, meta-analysis and dose-response of randomized clinical trials.

Crit Rev Food Sci Nutr. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: A revised tool for assessing risk of bias in randomised trials. Ibero-Baraibar I, Abete I, Navas-Carretero S, Massis-Zaid A, Martinez JA, Zulet MA. Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet.

Nutr Metab Cardiovasc Dis. Mielgo-Ayuso J, Barrenechea L, Alcorta P, Larrarte E, Margareto J, Labayen I. Effects of dietary supplementation with epigallocatechingallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial.

Silver HJ, Dietrich MS, Niswender KD. Effects of grapefruit, grapefruit juice and water preloads on energy balance, weight loss, body composition, and cardiometabolic risk in free-living obese adults.

Nutr Metab. Diepvens K, Kovacs EMR, Nijs IMT, Vogels N, Westerterp-Plantenga MS. Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females. Faghihzadeh F, Adibi P, Rafiei R, Hekmatdoost A.

Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease. Nutr Res. Llaneza P, González C, Fernandez-Iñarrea J, Alonso A, Diaz F, Arnott I, et al. Soy isoflavones, diet and physical exercise modify serum cytokines in healthy obese postmenopausal women.

Llaneza P, Gonzalez C, Fernandez-Iñarrea J, Alonso A, Diaz-Fernandez MJ, Arnott I, et al. For this reason, it has been considered as a therapeutic target to treat obesity. Another important factor to consider is the mechanism by which the human body controls energy intake, or calories, through hormonal signaling.

Overweight individuals can generate a resistance to certain hormones involved in the sensation of hunger or satiety. Simultaneously, leptin hormone levels, related to appetite control as well as fat storage, were decreased.

Actions can be taken to get the metabolism back on track. Content provided by DolCas Biotech, LLC. Viable natural product options for "healthy weight management" in the age of Ozempic and other GLP-1 inhibitors will require targeted innovations Content provided by KLK OLEO Jan Product Brochure.

MCTs Medium-Chain Triglycerides is a versatile single or blend of saturated medium-chain-length fatty acids derived from renewable natural sources. Content provided by BIONAP BIOACTIVE NATURAL PRODUCTS Oct Product Brochure.

Bionap also this year will showcase a selection of sustainable plant-based health and wellness solutions at booth SupplySide West that will Content provided by ADM: Innovation that Feeds the Future Oct White Paper.

Foods of plant origin have been Body shape goals recognized for manwgement Fast muscle soreness relief to weught health Manageement they Snakebite venom inhibition rich in bioactive Pklyphenols that make them nutritionally very interesting such Fast muscle soreness relief vitamins, fiber, or polyphenols. The latter are found in fruits, janagement, Polyphenols and weight management grains, cocoa, olive oil, red wine, tea, and coffee. In our diet, about individual polyphenols of different classes and subclasses have been identified. Polyphenols have proven to have antioxidant and anti-inflammatory properties among others, in addition, they could prevent or delay the risk of obesity and associated diseases such as diabetes, some types of cancers, or cardiovascular diseases. The Nutrition and Cancer Research Team of the Bellvitge Biomedical Research Institute IDIBELL and the Catalan Institute of Oncology ICO has evaluated the association between polyphenols consumption and body weight change.

Polyphenols and weight management -

Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis.

BMC Public Health. Gonzalez-Barroso MDM, Ricquier D, Cassard-Doulcier AM. The human uncoupling protein-1 gene UCP1 : present status and perspectives in obesity research.

Obesity reviews. Article Google Scholar. Vázquez-Vela MEF, Torres N, Tovar AR. White adipose tissue as endocrine organ and its role in obesity.

Arch Med Res. Fenzl A, Kiefer FW. Brown adipose tissue and thermogenesis. Horm Mol Biol Clin Invest. CAS Google Scholar. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance.

Physiol Rev. Green AL, Bagci U, Hussein S, Kelly PV, Muzaffar R, Neuschwander-Tetri BA, et al. Nucl Med Commun. Morton GJ, Muta K, Kaiyala KJ, Rojas JM, Scarlett JM, Matsen ME, et al. Evidence that the sympathetic nervous system elicits rapid, coordinated, and reciprocal adjustments of insulin secretion and insulin sensitivity during cold exposure.

Blondin DP, Tingelstad HC, Noll C, Frisch F, Phoenix S, Guérin B, et al. Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men. Nat Commun.

Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med. Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, et al. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.

Mol Cell Biol. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol.

Zhang X, Zhang QX, Wang X, Zhang L, Qu W, Bao B, et al. Int J Obes. Article CAS Google Scholar. Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma. Silvester AJ, Aseer KR, Yun JW.

Dietary polyphenols and their roles in fat browning. Li AN, Li S, Zhang YJ, Xu XR, Chen YM, Li HB. Resources and biological activities of natural polyphenols. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. Polyphenols: food sources and bioavailability.

Am J Clin Nutr. Marin L, Miguelez EM, Villar CJ, Lombo F. Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. Biomed Res Int. Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships.

Deby-Dupont G, Mouithys-Mickalad A, Serteyn D, Lamy M, Deby C. Resveratrol and curcumin reduce the respiratory burst of chlamydia-primed THP-1 cells. Biochem Biophys Res Commun. Braunlich M, Slimestad R, Wangensteen H, Brede C, Malterud KE, Barsett H. Extracts, anthocyanins and procyanidins from Aronia melanocarpa as radical scavengers and enzyme inhibitors.

Chu AJ. Antagonism by bioactive polyphenols against inflammation: a systematic view. Inflamm Allergy Drug Targets. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing h energy expenditure and fat oxidation in humans.

Decorde K, Teissedre PL, Sutra T, Ventura E, Cristol JP, Rouanet JM. Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers.

Mol Nutr Food Res. Arias N, Macarulla MT, Aguirre L, Milton I, Portillo MP. The combination of resveratrol and quercetin enhances the individual effects of these molecules on triacylglycerol metabolism in white adipose tissue.

Boque N, Campion J, de la Iglesia R, de la Garza AL, Milagro FI, San Roman B, et al. Screening of polyphenolic plant extracts for anti-obesity properties in Wistar rats.

J Sci Food Agric. Kim NH, Jegal J, Kim YN, Heo JD, Rho JR, Yang MH, et al. Chokeberry extract and its active polyphenols suppress Adipogenesis in 3T3-L1 adipocytes and modulates fat accumulation and insulin resistance in diet-induced obese mice. Alberdi G, Rodriguez VM, Miranda J, Macarulla MT, Churruca I, Portillo MP.

Thermogenesis is involved in the body-fat lowering effects of resveratrol in rats. Food Chem. Andrade JM, Frade AC, Guimaraes JB, Freitas KM, Lopes MT, Guimaraes AL, et al. Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet.

Wang S, Liang X, Yang Q, Fu X, Zhu M, Rodgers BD, et al. Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase AMPK alpha1 in mice fed high-fat diet. Carrasco-Pozo C, Cires MJ, Gotteland M.

Quercetin and Epigallocatechin Gallate in the prevention and treatment of obesity: from molecular to clinical studies. J Med Food. Forbes-Hernandez TY, Giampieri F, Gasparrini M, Afrin S, Mazzoni L, Cordero MD, et al.

Lipid accumulation in HepG2 cells is attenuated by strawberry extract through AMPK activation. Giampieri F, Alvarez-Suarez JM, Cordero MD, Gasparrini M, Forbes-Hernandez TY, Afrin S, et al. Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade.

Mosqueda-Solis A, Sanchez J, Portillo MP, Palou A, Pico C. Combination of capsaicin and hesperidin reduces the effectiveness of each compound to decrease the adipocyte size and to induce Browning features in adipose tissue of Western diet fed rats. J Agric Food Chem.

Neyrinck AM, Bindels LB, Geurts L, Van Hul M, Cani PD, Delzenne NM. A polyphenolic extract from green tea leaves activates fat browning in high-fat-diet-induced obese mice. Peng CH, Liu LK, Chuang CM, Chyau CC, Huang CN, Wang CJ. Mulberry water extracts possess an anti-obesity effect and ability to inhibit hepatic lipogenesis and promote lipolysis.

Prior RL, Wu X, Gu L, Hager TJ, Hager A, Howard LR. Han X, Guo J, You Y, Yin M, Liang J, Ren C, et al. Vanillic acid activates thermogenesis in brown and white adipose tissue.

Food Funct. Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Dinan TG, Cryan JF. Microbes, immunity, and behavior: psychoneuroimmunology meets the microbiome.

Hill DA, Artis D. Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol. Ringel-Kulka T, Cheng J, Ringel Y, Salojarvi J, Carroll I, Palva A, et al.

Intestinal microbiota in healthy U. young children and adults--a high throughput microarray analysis. PLoS One. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, et al. Diversity of the human intestinal microbial flora. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.

J Nutr. Kim E, Coelho D, Blachier F. Review of the association between meat consumption and risk of colorectal cancer. Nutr Res. Fujio-Vejar S, Vasquez Y, Morales P, Magne F, Vera-Wolf P, Ugalde JA, et al.

The gut microbiota of healthy Chilean subjects reveals a high abundance of the phylum Verrucomicrobia. Front Microbiol. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI.

Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A. Wong JM, de Souza R, Kendall CW, Emam A, Jenkins DJ. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. Rosenbaum M, Knight R, Leibel RL. The gut microbiota in human energy homeostasis and obesity.

Trends Endocrinol Metab. Cummings JH, Macfarlane GT. Role of intestinal bacteria in nutrient metabolism. JPEN J Parenter Enteral Nutr. Vinolo MA, Rodrigues HG, Nachbar RT, Curi R.

Regulation of inflammation by short chain fatty acids. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, et al. The gut microbiota as an environmental factor that regulates fat storage.

Velagapudi VR, Hezaveh R, Reigstad CS, Gopalacharyulu P, Yetukuri L, Islam S, et al. The gut microbiota modulates host energy and lipid metabolism in mice. J Lipid Res. Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Muller M, et al.

J Biol Chem. Backhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Jenner AM, Rafter J, Halliwell B. Human fecal water content of phenolics: the extent of colonic exposure to aromatic compounds. Free Radic Biol Med.

Braune A, Engst W, Blaut M. Identification and functional expression of genes encoding flavonoid O- and C-glycosidases in intestinal bacteria. Environ Microbiol. Rechner AR, Smith MA, Kuhnle G, Gibson GR, Debnam ES, Srai SK, et al. Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products.

Braune A, Blaut M. Bacterial species involved in the conversion of dietary flavonoids in the human gut. Gut Microbes.

Monagas M, Urpi-Sarda M, Sanchez-Patan F, Llorach R, Garrido I, Gomez-Cordoves C, et al. Insights into the metabolism and microbial biotransformation of dietary flavanols and the bioactivity of their metabolites.

Kawai Y, Nishikawa T, Shiba Y, Saito S, Murota K, Shibata N, et al. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids.

Bolca S, Van de Wiele T, Possemiers S. Gut metabotypes govern health effects of dietary polyphenols. Curr Opin Biotechnol. van Duynhoven J, Vaughan EE, Jacobs DM, Kemperman RA, van Velzen EJ, Gross G, et al. Metabolic fate of polyphenols in the human superorganism.

Garcia-Villalba R, Vissenaekens H, Pitart J, Romo-Vaquero M, Espin JC, Grootaert C, et al. Gastrointestinal simulation model TWIN-SHIME shows differences between human Urolithin-Metabotypes in gut microbiota composition, pomegranate polyphenol metabolism, and transport along the intestinal tract.

Tomas-Barberan FA, Selma MV, Espin JC. Interactions of gut microbiota with dietary polyphenols and consequences to human health. Curr Opin Clin Nutr Metab Care. Chevalier C, Stojanovic O, Colin DJ, Suarez-Zamorano N, Tarallo V, Veyrat-Durebex C, et al.

Gut microbiota orchestrates energy homeostasis during cold. Bortolin RC, Vargas AR, de Miranda RV, Gasparotto J, Chaves PR, Schnorr CE, et al. Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation.

Phytother Res. Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, et al. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Li Z, Yi CX, Katiraei S, Kooijman S, Zhou E, Chung CK, et al. Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit.

Prasain JKG, C. Cranberry anti-cancer compounds and their uptake and metabolism: an updated review. Journal of Berry Research. May SM, G. Impact of black raspberries on the normal and malignant Apc deficient murine gut microbiome.

Pan P, Oshima K, Huang YW, Yearsley M, Zhang J, Arnold M, et al. J Berry Res. Pierre JF, Martinez KB, Ye H, Nadimpalli A, Morton TC, Yang J, et al.

Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice. Am J Physiol Gastrointest Liver Physiol. Brandl K, Kumar V, Eckmann L. Gut-liver axis at the frontier of host-microbial interactions. Fiorucci S, Mencarelli A, Palladino G, Cipriani S.

Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders. Trends Pharmacol Sci. Pathak P, Xie C, Nichols RG, Ferrell JM, Boehme S, Krausz KW, et al. Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, et al. TGR5-mediated bile acid sensing controls glucose homeostasis.

Cell Metab. Hui S, Liu Y, Huang L, Zheng L, Zhou M, Lang H, et al. Resveratrol enhances brown adipose tissue activity and white adipose tissue browning in part by regulating bile acid metabolism via gut microbiota remodeling.

Wang P, Li D, Ke W, Liang D, Hu X, Chen F. Am J Physiol Endocrinol Metab. Violi F, Loffredo L, Pigatelli P, Angelico F, Bartimoccia S, Nocella C, et al. Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects.

Nutr Diabetes. Carnevale R, Loffredo L, Del Ben M, Angelico F, Nocella C, Petruccioli A, et al. Extra virgin olive oil improves post-prandial glycemic and lipid profile in patients with impaired fasting glucose. Clin Nutr. Chuang CC, McIntosh MK.

Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases. Annu Rev Nutr. Méndez L, Medina I. Polyphenols and fish oils for improving metabolic health: a revision of the recent evidence for their combined nutraceutical effects.

Pagliaro M, Pizzone DM, Scurria A, Lino C, Paone E, Mauriello F, et al. Sustainably sourced olive polyphenols and ômega-3 marine lipids: a synergy fostering public health. ACS Food Sci Technol. CrossRef Full Text Google Scholar. Pan H, Gao Y, Tu Y.

Mechanisms of body weight reduction by black tea polyphenols. Manach C, Mazur A, Scalbert A. Polyphenols and prevention of cardiovascular diseases.

Curr Opin Lipidol. Hodgson JM, Croft KD. Tea flavonoids and cardiovascular health. Mol Aspects Med. Cheng YC, Sheen JM, Hu WL, Hung YC. Polyphenols and oxidative stress in atherosclerosis-related ischemic heart disease and stroke.

Oxid Med Cell Longev. Giglio RV, Patti AM, Cicero AFG, Luppi G, Rizzo M, Toth PP, et al. Polyphenols: potential use in the prevention and treatment of cardiovascular diseases. Curr Pharm Des. Tang GY, Meng X, Gan RY, Zhao CN, Liu Q, Feng YB, et al. Health functions and related molecular mechanisms of tea components: an update review.

Laraia BA, Leak TM, Tester JM, Leung CW. Biobehavioral factors that shape nutritional in low-income populations: a narrative review. Am J Prev Med. Jones NRV, Conklin AI, Suhrcke M, Monsivais P.

The growing price gap between more and less healthy foods: analysis of a novel longitudinal UK dataset. PLoS ONE. Seguin R, Connor L, Nelson M, LaCroix A, Eldridge G. Understanding barriers and facilitators to healthy eating and active living in rural communities.

J Nutr Metab. Fard NA, Morales GF, Mejova Y, Schifanella R. On the interplay between educational attainment and nutrition: a spatially-aware perspective. EPJ Data Sci. Zhu F, Du B, Zheng L, Li J. Advance on the bioactivity and potential applications of dietary fibre from grape pomace. Food Chem.

Ribeiro LF, Ribani RH, Francisco TMG, Soares AA, Pontarolo R, Haminiuk CWI. Profile of bioactive compounds from grape pomace Vitis vinifera and Vitis labrusca by spectrophotometric, chromatographic and spectral analyses.

J Chromatogr B Analyt Technol Biomed Life Sci. Rasines-Perea Z, Teissedre PL. Grape polyphenols' effects in human cardiovascular diseases and diabetes. Talhaoui N, Gómez-Caravaca AM, León L, De la Rosa R, Fernández-Gutiérrez A, Segura-Carretero A.

From olive fruits to olive oil: phenolic compound transfer in six different olive cultivars grown under the same agronomical conditions. Dal S, Sigrist S.

The protective effect of antioxidants consumption on diabetes and vascular complications. Lamien-Meda A, Lamien CE, Compaoré MMY, Meda RNT, Kiendrebeogo M, Zeba B, et al. Polyphenol content and antioxidant activity of fourteen wild edible fruits from Burkina Faso.

Shan S, Huang X, Shah MH, Abbasi AM. Evaluation of polyphenolics content and antioxidant activity in edible wild fruits. Biomed Res Int. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Kumar V, Sharma A, Kohli SK, Bali S, Sharma M, Kumar R, et al. Differential distribution of polyphenols in plants using multivariate techniques.

Biotechnol Res Innov. Serreli G, Deiana M. Biological relevance of extra virgin olive oil polyphenols metabolites. Lima GPP, Vianello F, Corrêa CR, Campos RAS, Borguini MG.

Polyphenols in fruits and vegetables and its effect on human health. Food Nutr Sci. Xu DP, Li Y, Meng X, Zhou T, Zhou Y, Zheng J, et al.

Natural antioxidants in foods and medicinal plants: Extraction, assessment and resources. Wei Z, Luo J, Huang Y, Guo W, Zhang Y, Guan H, et al. Profile of polyphenol compounds of five muscadine grapes cultivated in the United States and in newly adapted locations in China.

Liu C, Guo Y, Sun L, Lai X, Li Q, Zhang W, et al. Six types of tea reduce high-fat diet-induced fat accumulation in mice by increasing lipid metabolism and suppressing inflammation. Food Funct. Chuang CC, Shen W, Chen H, Xie G, Jia W, Chung S, et al. Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice.

Pascual-Serrano A, Arola-Arnal A, Suárez-García S, Bravo FI, Suárez M, Arola L, et al. Grape seed proanthocyanidin supplementation reduces adipocyte size and increases adipocyte number in obese rats. Int J Obes. Elmhdwi MF, Elaali NMS, Mohamed NN, Muktar MA, Buzgeia NB.

Anti-diabetic activity of methanolic extract of grape seeds in alloxan induced diabetic rats. Agr Res Tech. Ballard CR, Santos EF, Dubois MJ, Pilon G, Cazarin CBB, Maróstica Junior MR, et al.

Two polyphenol-rich Brazilian fruit extracts protect from diet-induced obesity and hepatic steatosis in mice. Ebaid H, Bashandy SAE, Alhazza IM, Hassan I, Al-Tamimi J. Efficacy of a methanolic extract of Adansonia digitata leaf in alleviating hyperglycemia, hyperlipidemia, and oxidative stress of diabetic rats.

Vazquez A, Sanchez-Rodriguez E, Vargas F, Montoro-Molina S, Romero M, Espejo-Calvo JA, et al. Cardioprotective effect of a virgin olive oil enriched with bioactive compounds in spontaneously hypertensive rats. Jurado-Ruiz E, Álvarez-Amor L, Varela LM, Bern á G, Parra-Camacho MS, Oliveira-Lopez MJ, et al.

Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice. Sci Rep. Weisberg SP, Leibel R, Tortoriello DV. Dietary curcumin significantly improves obesity- associated inflammation and diabetes in mouse models of diabesity.

Seo KI, Lee J, Choi RY, Lee HI, Lee JH, Jeong YK, et al. Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice. Oliveira PR, Costa CA, Bem GF, Cordeiro VSC, Santos IB, Carvalho LCRM, et al. Euterpe oleracea Mart. Panchal SK, Poudyal H, Waanders J, Brown L.

Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats.

J Nutr. Boqué N, Iglesia R, Garza AL, Milagro FI, Olivares M, Bañuelos O, et al. Prevention of diet-induced obesity by apple polyphenols in Wister rats through regulation of adipocyte gene expression and DNA methylation patterns. Mol Nutr Food Res. Azman KF, Amom Z, Azlan A, Esa NM, Ali RM, Shah ZM, et al.

Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats. J Nat Med. Aranaz P, Navarro-Herrera D, Romo-Hualde A, Zabala M, López-Yoldi M, González-Ferrero C, et al.

Broccoli extract improves high fat diet-induced obesity, steatosis and glucose intolerance in Wistar rats. J Funct Foods. Lambert JD, Sang S, Yang CS.

Possible controversy over dietary polyphenols: benefits vs risks. Chem Res Toxicol. Mennen LI, Walker R, Bennetau-Pelissero C, Scalbert A.

Risks and safety of polyphenols consumption. Am J Clin Nutr. Ofosu FK, Daliri EBM, Elahi F, Chelliah R, Lee BH, Oh DH. New insights on the use of polyphenols as natural preservatives and their emerging safety concerns. Front Sustain Food Syst.

Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su R, et al. Novel insights of dietary polyphenols and obesity. J Nutr Biochem. Zunino SJ, Peerson JM, Freytag TL, Breksa AP, Bonnel EL, Woodhouse LR, et al.

Dietary grape powder increases IL-1β and IL-6 production by lipopolysaccharide- activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans.

Br J Nutr. Chew B, Mathison B, Kimble L, McKay D, Kaspar K, Khoo C, et al. Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a ranamized controlled trial.

Eur J Nutr. Álvarez-Pérez J, Sánchez-Villegas A, Díaz-Benítez EM, Ruano-Rodríguez C, Corella D, Martínez-González AM, et al. Influence of a Mediterranean dietary pattern on body fat distribution: results of the PREDIMED—Canarias intervention randomized trial.

J Am Coll Nutr. Lum T, Connolly M, Marx A, Beidler J, Hooshmand S, Kern M, et al. Effects of fresh watermelon consumption on the acute satiety response and cardiometabolic risk factors in overweight and obese adults.

Balsan G, Pellanda LC, Sausen G, Galarraga T, Zaffari D, Pontin B, et al. Effect of yerba mate and green tea on paraoxonase and leptin levels in patients affected by overweight or obesity and dyslipidemia: a randomized clinical trial.

Nutr J. Herranz-López M, Olivares-Vicente M, Boix-Castejón M, Caturla N, Roche E, Micol V. Azzini E, Venneria E, Ciarapica D, Foddai MS, Intorre F, Zaccaria M, et al.

Zunino SJ, Parelman MA, Freytag TL, Stephensen CB, Kelley DS, Mackey BE, et al. Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects.

Roussel AM, Hininger I, Benaraba R, Ziegenfuss TN, Anderson RA. Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. Leverrier A, Daguet D, Calame W, Dhoye P, Kodimule SP. Helianthus annuus seed extract affects weight and body composition of healthy obese adults during 12 weeks of consumption: a randomized, double-blind, placebo-controlled pilot study.

Saini RK, Shetty N, Giridhar P. J Am Oil Chem Soc. Saini RK, Shang XM, Ko EY, Choi JH, Kim D, Keum YS.

Characterization of nutritionally important phytoconstituents in minimally processed ready-to-eat baby-leaf vegetables using HPLC-DAD and GC-MS. J Food Meas Charact. Kim DE, Shang X, Assefa AD, Keum YS, Saini RK. Food Res Int.

Hernández-Martínez M, Gallardo-Velázquez T, Osorio-Revilla G, Castañeda-Pérez E, Uribe-Hernández K. Characterization of Mexican fishes according to fatty acid profile and fat nutritional indices. Int J Food Prop. Sharafi Y, Majidi MM, Goli SAH, Rashidi F.

Oil content and fatty acids composition in Brassica species. Pereira H, Barreira L, Figueiredo F, Custódio L, Vizetto-Duarte C, Polo C, et al. Polyunsaturated fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications.

Mar Drugs. Ramos Filho MM, Ramos MIL, Hiane PA, Souza EMT. Nutritional value of seven freshwater fish species from the Brazilian Pantanal. Halinski LP, Topolewska A, Rynkowska A, Mika A, Urasinska M, Czerski M, et al.

Impact of plant domestication on selected nutrient and anti-nutrient compounds in Solanaceae with edible leaves Solanum spp. Genet Rosour Crop Evol. Ljubojevic D, Trbovic D, Lujic J, Bjelic-Cabrilo O, Kostic D, Novaov N, et al.

Fatty acid composition of fishes from inland waters. Bulg J Agric Sci. Peltomaa E, Johnson MD, Taipale SJ. Marine cryptophytes are great sources of EPA and DHA.

Saini RK, Keum YS. Omega-3 and omega-6 polyunsaturated fatty acids: dietary sources, metabolism, and significance—a review. Life Sci. Shahidi F, Ambigaipalan P. Omega-3 polyunsaturated fatty acids and their health benefits.

Annu Rev Food Sci Technol. Burns-Whitmore B, Froyen E, Heskey C, Parker T, Pablo GS. Bazinet RP, Layé S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. Long EK, Picklo MJ Sr.

Transhydroxyhexenal, a product of n-3 fatty acid peroxidation: make some room HNE. Free Radic Biol Med. Tanaka R, Shigeta K, Sugiura Y, Hatate H, Matsushita T. Accumulation of hydroxyl lipids and 4-hydroxyhexenal in live fish infected with fish diseases.

Tao L. Oxidation of polyunsaturated fatty acids and its impact on food quality and human health. Adv Food Technol Nutr Sci Open J. Ward PA. Resolvins on the way to resolution. J Exp Med. Zhang J, Freund MA, Culler MD, Yang R, Chen PB, Park Y, et al. How to stabilize ω-3 polyunsaturated fatty acids PUFAs in an animal feeding study?

Halvorsen BL, Blomhoff R. Determination of lipid oxidation products in vegetable oils and marine omega-3 supplements. Food Nutr Res. Bastías JM, Balladares P, Acuña S, Quevedo R, Muñoz O.

Determining effect of different cooking methods on the nutritional composition of salmon Salmo salar and Chilean jack mackerel Trachurus murphyi fillets. Leung KS, Galano JM, Durand T, Lee JCY. Profiling of omega-polyunsaturated fatty acids and their oxidized products in salmon after different cooking methods.

Damanik M, Murkovic M. The stability of palm oils during heating in a rancimat. Eur Food Res Tech. Hassanien MMM, Abdel-Razek AG, Rudzinska M, Siger A, Ratusz K, Przybylski R. Phytochemical contents and oxidative stability of oils from non-traditional sources. Eur J Lipid Sci Tech.

Shadyro O, Sosnovskaya A, Edimecheva I. Effect of biologically active substances on oxidative stability. J Food Sci Technol. Pérez-Matute P, Pérez-Echarri N, Martínez JA, Marti A, Moreno-Aliaga MJ. Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: Role of apoptosis, adiponectin and tumour necrosis factor-α.

Brit J Nutr. Hassanali Z, Ametaj BN, Field CJ, Proctor SD, Vine DF. Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat. Diabetes Obes Metab. Castro GS, Deminice R, Simões-Ambrosio LMC, Calder PC, Jordão AA, Vannucchi H.

Dietary docosahexaenoic acid and eicosapentaenoic acid influence liver triacylglycerol and insulin resistance in rats fed a high-fructose diet. Shang T, Liu L, Zhou J, Zhang M, Hu Q, Fang M, et al. Lipids Health Dis. Huber J, Löffler M, Bilban M, Reimers M, Kadl A, Todoric J, et al. Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids.

Inter J Obes. Pauter AM, Fischer AW, Bengtsson T, Asadi A, Talamonti E, Jacobsson A. Soni N, Ross AB, Scheers N, Nookaew I, Gabrielsson BG, Sandberg AS.

The omega-3 fatty acids EPA and DHA, as a part of a murine high-fat diet, reduced lipid accumulation in brown and white adipose tissues. Liu HQ, Qiu Y, Mu Y, Zhang XJ, Liu L, Hou XH, et al. Nutr Res. Demizieux L, Piscitelli F, Troy-Fioramonti S, Iannotti FA, Borrino S, Gresti J, et al.

Early low-fat diet enriched with linolenic acid reduces liver endocannabinoid tone and improves late glycemic control after a high-fat diet challenge in mice. Tyagi A, Kumar U, Reddy S, Santosh VS, Mohammed SB, Ehtesham NZ, et al. Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease.

Mayer C, Côme M, Ulmann L, Zittelli GC, Faraloni C, Hassan N, et al. Preventive effects of the marine microalga Phaeodactylum triconutum , used as a food supplement, on risk factors associated with metabolic syndrome in Wistar rats.

Chewcharat A, Chewcharat P, Rutirapong A, Papatheodorou S. The effects of omega-3 fatty acids on diabetic nephropathy: a meta-analysis of randomized controlled trials. Chen C, Yu X, Shao S. Effects of omega-3 fatty acid supplementation on glucose control and lipid levels in type 2 diabetes: a meta-analysis.

Du S, Jin J, Fang W, Su Q.

Background: Both, Polypenols restricted diets CRD Enhance thermogenic performance physical activity PA are conventional obesity Polyphenols and weight management but their effectiveness Self-esteem usually limited in the long-term. Polyphenols are bioactive compounds that have shown to possess Polyphenoks anti-obesity managemwnt. The synergic effects between weighht polyphenols and CRD Fast muscle soreness relief PA on body weight and fat are supported by several animal studies, but evidence in human is still inconsistent. Both, quality and risk of bias of the included studies were assessed using the Cochrane RoB2 Tool. Results: The review included 4 and 11 RCTs investigating the anti-obesity effects of polyphenol supplementation combined with CRD and PA, respectively. Isoflavone supplementation may increase fat loss during exercise among post-menopausal women in non-Asian studies. In the rest of RCTs regarding polyphenol supplementation and CRD or PA, no additive changes were found.

Video

3 Insane Health Benefits of Polyphenols: Your Ultimate Gut Microbiome Boosters - Dr. Steven Gundry

Obesity is a global public health problem that results Appetite suppressants for men chronic pathologies such as diabetes, cardiovascular diseases, and Polypjenols.

The treatment approach based on energy Polyphneols and promotion of Self-esteem activity is ineffective in the Polyyphenols term, Self-esteem. Due to the high prevalence of this pathology, complementary treatments such as brown adipose tissue activation BAT and white adipose weigut browning WAT have been proposed.

Dietary polyphenols are mansgement secondary metabolites that can Self-esteem browning and thermogenesis of adipose tissue. Manaement have also been shown to prevent body Fast muscle soreness relief gain, and decrease systemic inflammation produced by high-fat diets.

Ingested dietary polyphenols Diabetic neuropathy lifestyle adjustments reach Fast muscle soreness relief colon manayement metabolized by the Cellulite reduction treatments microbiota GMregulating its composition and generating a great array of metabolites.

GM is Polyphenolls in Polypgenols production of short Polyphsnols fatty acids and secondary bile salts that regulate energetic metabolism. The Self-esteem in the composition of GM observed Fast muscle soreness relief metabolic diseases such as obesity and type 2 diabetes can be Pokyphenols by polyphenols.

Recent studies support the hypothesis that GM would mediate WAT browning and BAT thermogenesis activation induced by polyphenol administration. Together, these results indicate annd GM in the presence of polyphenols plays Effective ways to reduce cellulite fundamental role in the control of obesity Muscle definition exercises through BAT weignt.

This is a Weitht of subscription content, log in via Polyphenlos institution to check access. Rent this weiht via DeepDyve. Hydration for athletes subscriptions. Zukiewicz-Sobczak W, Wroblewska P, Zwolinski J, Chmielewska-Badora J, Adamczuk P, Krasowska E, et al.

Obesity and poverty paradox in developed countries. Ann Agric Environ Polyphehols. Article PubMed Google Scholar. Yudkin JS. Inflammation, obesity, Polyphenops the metabolic weighy. Horm Metab Res. Article Managemenr PubMed Google Scholar. Concha F, Prado G, Self-esteem J, Ramirez A, Bravo N, Flores C, et al.

Nutritional and non-nutritional agents anc stimulate white adipose tissue browning. Rev Endocr Metab Disord.

Bohn T. Dietary weighht affecting polyphenol bioavailability. Poluphenols Rev. Rowland I, Gibson G, Heinken A, Scott K, Swann J, Thiele I, et al.

Gut microbiota functions: metabolism nad nutrients and other food components. Eur J Nutr. Harakeh SM, Khan I, Kumosani T, Barbour E, Almasaudi SB, Bahijri SM, et al.

Gut microbiota: a contributing factor to obesity. Front Cell Infect Microbiol. Article PubMed PubMed Mabagement Google Scholar. Magne F, Gotteland M, Gauthier L, Zazueta A, Pesoa S, Navarrete P, et managwment. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, et al.

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced Polyphenold and diabetes in mice. Gasaly NRK, Gotteland M. Phytochemicals: a new class manageent prebiotics. Rev Chil Nutr. Pan Pllyphenols, Lam V, Salzman N, Huang YW, Yu J, Zhang J, et al.

Black raspberries and their anthocyanin managemment Fiber fractions Alter the composition and diversity of gut microbiota in F rats.

Nutr Cancer. Article CAS PubMed PubMed Central Google Scholar. Etxeberria U, Arias N, Boque N, Macarulla MT, Portillo MP, Martinez JA, et al. Reshaping faecal gut microbiota composition by Polypbenols intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats.

J Nutr Biochem. Cani PD, Van Hul M, Lefort C, Depommier C, Rastelli M, Everard A. Microbial regulation of organismal energy homeostasis. Nat Metab. Hartroft WS. The pathology of obesity. Bull N Y Acad Med.

CAS PubMed PubMed Central Google Scholar. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, managemet al. Increased oxidative stress in obesity managment its impact on metabolic syndrome. J Clin Invest.

Guh DP, Mqnagement W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence managgement co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. Gonzalez-Barroso MDM, Ricquier D, Cassard-Doulcier AM. The human uncoupling protein-1 gene UCP1 : present status and perspectives in obesity research.

Obesity reviews. Article Google Scholar. Vázquez-Vela MEF, Torres Welght, Tovar AR. White adipose tissue as endocrine organ and its role in obesity. Arch Med Res. Fenzl A, Kiefer FW. Brown adipose tissue and thermogenesis.

Horm Mol Biol Clin Invest. CAS Google Scholar. Cannon B, Nedergaard J. Polylhenols adipose tissue: function and physiological significance. Physiol Rev. Green AL, Bagci U, Hussein S, Kelly PV, Muzaffar R, Neuschwander-Tetri BA, et al.

Nucl Med Commun. Morton GJ, Muta K, Kaiyala KJ, Qeight JM, Scarlett JM, Matsen ME, et al. Evidence that the sympathetic nervous system elicits rapid, coordinated, maangement reciprocal adjustments of insulin secretion and insulin sensitivity during cold exposure. Blondin DP, Tingelstad HC, Noll C, Frisch F, Phoenix S, Guérin B, et al.

Dietary fatty acid metabolism of Polyphenoks adipose tissue in cold-acclimated men. Nat Commun. Harms M, Seale P. Brown and beige fat: development, ad and therapeutic potential.

Nat Med. Cao W, Daniel KW, Robidoux J, Puigserver P, Polyphenils AV, Bai X, et al. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of maanagement brown fat mnaagement protein 1 gene.

Mol Cell Biol. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol. Zhang X, Zhang QX, Wang X, Zhang L, Qu W, Bao B, et al. Int J Obes. Article CAS Google Scholar.

Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma. Silvester AJ, Aseer KR, Yun JW. Dietary ad and their roles in fat browning.

: Polyphenols and weight management

Introduction Sensitivity analysis among men only the majority of this cohort is presented in S 2 and Additional file 1 : Fig. Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort. Leung KS, Galano JM, Durand T, Lee JCY. Article CAS PubMed Google Scholar Cani PD, Van Hul M, Lefort C, Depommier C, Rastelli M, Everard A. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis.
Background

Silvester AJ, Aseer KR, Yun JW. Dietary polyphenols and their roles in fat browning. Iris S, Dan S, Henkin Y, et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med. Schwarzfuchs D, Golan R, Shai I. Four-year follow-up after two-year dietary interventions.

Gepner Y, Golan R, Harman-Boehm I, et al. Effects of initiating moderate alcohol intake on cardiometabolic risk in adults with type 2 diabetes: a 2-year randomized, controlled trial.

Ann Intern Med. Yaskolka Meir A, Tsaban G, Zelicha H, et al. A green Mediterranean diet, low in meat and supplemented with duckweed, does not impair iron homeostasis in obese, dyslipidemic adults or rats.

J Nutr. Google Scholar. Tsaban G, Yaskolka Meir A, Rinott E, Zelicha H, Kaplan A, Shalev A, et al. The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial.

Yaskolka Meir A, Rinott E, Tsaban G, et al. Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial. Moll R, Davis B. Iron, vitamin B12 and folate. Shai I, Rosner BA, Shahar DR, et al.

Dietary evaluation and attenuation of relative risk: multiple comparisons between blood and urinary biomarkers, food frequency, and hour recall questionnaires: the DEARR study. Pereira JM, Sirlin CB, Pinto PS, Casola G.

CT and MR imaging of extrahepatic fatty masses of the abdomen and pelvis: techniques, diagnosis, differential diagnosis, and pitfalls. Monzon JR, Basile R, Heneghan S, Udupi V, Green A.

Lipolysis in adipocytes isolated from deep and superficial subcutaneous adipose tissue. Obes Res. Lancerotto L, Stecco C, Macchi V, Porzionato A, Stecco A, De Caro R. Layers of the abdominal wall: anatomical investigation of subcutaneous tissue and superficial fascia.

PubMed Google Scholar. Khan T, Muise E, Iyengar P, et al. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI.

Mol Cell Biol. Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of cardiovascular disease with Mediterranean diets: the PREDIMED trial. Ahmad S, Demler OV, Sun Q, Moorthy MV, Li C, Lee IM, et al. JAMA Netw Open. Salas-Salvadó J, Nica Bulló M, Estruch R, Ros E, Covas M-I, Ria Ibarrola-Jurado N, et al.

Prevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial. Guasch-Ferré M, Willett WC. The Mediterranean diet and health: a comprehensive overview.

J Intern Med. Barnard ND, Alwarith J, Rembert E, et al. A Mediterranean diet and low-fat vegan diet to improve body weight and cardiometabolic risk factors: a randomized, cross-over trial.

J Am Coll Nutr. Ristic-Medic D, Kovacic M, Takic M, Arsic A, Petrovic S, Paunovic M, et al. Calorie-restricted Mediterranean and low-fat diets affect fatty acid status in individuals with nonalcoholic fatty liver disease.

Article PubMed Central Google Scholar. Mayr HL, Itsiopoulos C, Tierney AC, et al. Ad libitum Mediterranean diet reduces subcutaneous but not visceral fat in patients with coronary heart disease: a randomised controlled pilot study.

Clin Nutr ESPEN. Bray GA, Smith SR, de Jonge L, et al. Effect of dietary protein content on weight gain, energy expenditure, and body composition during overeating: a randomized controlled trial. de Souza RJ, Bray GA, Carey VJ, et al. Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial.

Am J Clin Nutr. Maersk M, Belza A, Stodkilde-Jorgensen H, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Shah RV, Murthy VL, Allison MA, et al.

Diet and adipose tissue distributions: the multi-ethnic study of atherosclerosis. Rosqvist F, Iggman D, Kullberg J, et al. Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans. Yaskolka Meir A, Tuohy K, von Bergen M, Krajmalnik-Brown R, Heinig U, Zelicha H, et al.

The metabolomic-gut-clinical axis of Mankai plant-derived dietary polyphenols. Kaplan A, Zelicha H, Tsaban G, Yaskolka Meir A, Rinott E, Kovsan J, et al.

Protein bioavailability of Wolffia globosa duckweed, a novel aquatic plant — a randomized controlled trial. Clin Nutr. Zelicha H, Kaplan A, Meir AY, Tsaban G, Rinott E, Shelef I, et al. The effect of Wolffia globosa Mankai, a green aquatic plant, on postprandial glycemic response: a randomized crossover controlled trial.

Toney AM, Fox D, Chaidez V, Ramer-Tait AE, Chung S. Immunomodulatory role of urolithin A on metabolic diseases. Pallister T, Jackson MA, Martin TC, Glastonbury CA, Jennings A, Beaumont M, et al.

Untangling the relationship between diet and visceral fat mass through blood metabolomics and gut microbiome profiling. Int J Obes Lond. Manach C, Scalbert A, Morand C, Remesy CJL. Polyphenols: food sources and bioavailability. Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H, et al.

Eur Heart J. Li P, Stuart EA, Allison DB. Multiple imputation: a flexible tool for handling missing data. Benjamini Y, Hochberg Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J Roy Stat Soc B Met. Download references.

We thank the DIRECT-PLUS participants for their valuable contributions. We thank the California Walnut Commission, Wissotzky Tea Company, and Hinoman, Ltd. for kindly supplying food items for this study. We thank Dr.

Dov Brikner, Efrat Pupkin, Eyal Goshen, Avi Ben Shabat, Benjamin Sarusi, and Evyatar Cohen from the Nuclear Research Center Negev and Liz Shabtai from Ben-Gurion University of the Negev for their valuable contributions to this study.

This work was supported by grants from the German Research Foundation DFG , German Research Foundation - project number - SFB ; B11 to I. Klöting, and M.

Blüher; Israel Ministry of Health grant to I. Shai ; Israel Ministry of Science and Technology grant to I. Shai , and the California Walnuts Commission to I. None of the funding providers was involved in any stage of the design, conduct, or analysis of the study, and they had no access to the study results before publication.

Department of Medicine, University of Leipzig, Leipzig, Germany. Nora Kloting, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Department of Engineering, Sapir Academic College, Ashkelon, Israel.

Helmholtz Institute for Metabolic, Obesity and Vascular Research HI-MAG of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.

Department of Epidemiology, Harvard T. Chan School of Public Health, Boston, MA, USA. Department of Nutrition, Harvard T. You can also search for this author in PubMed Google Scholar.

HZ had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Concept and design: IS. Conduct of the study: HZ, AK, AYM, ER, GT, and IS.

Collection, management, analysis, and interpretation of the data: all authors. Review and approval of the manuscript: all authors.

Statistical analysis: HZ. Supervision: IS. All authors read and approved the final manuscript. Correspondence to Iris Shai. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Adherence to the intervention. Sensitivity analysis.

Inclusion and Exclusion criteria. Physical activity recommendations protocol. Polyphenol-rich foods, provided at no cost to participants. Magnetic resonance imaging. Clinical parameters, laboratory methodology, and blood and urine polyphenols assessments. Sample size and power calculations.

DIRECT PLUS flow chart. Heatmap of abdominal adipose depots and metabolic and cardiovascular parameters at baseline. Illustrative MRI image.

The association between Mankai consumption and lipid profile change among the green-MED group DIRECT PLUS. Table S1. Outline of dietary and PA recommendations.

Open Access This article is licensed under a Creative Commons Attribution 4. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.

If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

Reprints and permissions. Zelicha, H. et al. The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial. BMC Med 20 , Download citation. Received : 16 February Accepted : 11 August Published : 30 September Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Research article Open access Published: 30 September The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial Hila Zelicha 1 , Nora Kloting 2 , Alon Kaplan 1 , Anat Yaskolka Meir 1 , Ehud Rinott 1 , Gal Tsaban 1 , Yoash Chassidim 3 , Matthias Bluher 4 , Uta Ceglarek 2 , Berend Isermann 2 , Michael Stumvoll 2 , Rita Nana Quayson 2 , Martin von Bergen 2 , Beatrice Engelmann 2 , Ulrike E.

Rolle-Kampczyk 2 , Sven-Bastiaan Haange 2 , Kieran M. Tuohy 5 , Camilla Diotallevi 5 , Ilan Shelef 6 , Frank B. Abstract Background Mediterranean MED diet is a rich source of polyphenols, which benefit adiposity by several mechanisms. Methods In the month Dietary Intervention Randomized Controlled Trial PoLyphenols UnproceSsed DIRECT-PLUS weight-loss trial, participants were randomized to A healthy dietary guidelines HDG , B MED, or C green-MED diets, all combined with physical activity.

Trial registration ClinicalTrials. gov , NCT Background Visceral adipose tissue VAT accumulation is one of the main key factors that differentiate between metabolic healthy and unhealthy obese individuals [ 1 , 2 ].

Results Baseline characteristics DIRECT-PLUS participants Table 1 ; Additional file 1 : Fig. Full size image. Discussion In this month dietary intervention study, the green-MED diet, richer in dietary polyphenols and green plant-based proteins and lower in red meat, might be a more effective strategy for VAT loss than the traditional healthy MED diet achieving more than twice the degree of VAT reduction, despite similar weight loss.

Conclusion A green-MED diet enriched with polyphenols and decreased red meat consumption might serve as an improved version of the MED diet for targeted VAT reduction.

Methods Study design The DIRECT-PLUS trial ClinicalTrials. Outcome measures The abdominal fat depots were assessed at two time points, baseline and 18 months thereafter, using 3-T MRI Philips Ingenia 3.

Statistical analysis The co-primary outcomes of the DIRECT PLUS study were month changes in abdominal fat, the previously published intrahepatic fat IHF [ 28 ], and obesity. Availability of data and materials The majority of results corresponding to the current study are included in the article or uploaded as supplementary material.

Abbreviations CVD: Cardiovascular disease ECG: Epicatechin gallate EGC: Epigallocatechin EGCG: Epigallocatechin gallate FDR: False discovery rate GAE: Gallic acid equivalents HDG: Healthy dietary guidelines IHF: Intrahepatic fat MED: Mediterranean MET: Metabolic equivalent PA: Physical activity SAT: Subcutaneous adipose tissue T2D: Type 2 diabetes VAT: Visceral adipose tissue WC: Waist circumference.

References Kang YM, Jung CH, Cho YK, Jang JE, Hwang JY, Kim EH, et al. Article PubMed PubMed Central Google Scholar Navarro E, Funtikova AN, Fíto M, Schröder H. Article CAS PubMed Google Scholar Stefan N. Article PubMed Google Scholar Neeland IJ, et al.

Article PubMed Google Scholar Kuk JL, Katzmarzyk PT, Nichaman MZ, Church TS, Blair SN, Ross R. Article Google Scholar Després JP. Article PubMed Google Scholar Neeland IJ, Turer AT, Ayers CR, Powell-Wiley TM, Vega GL, Farzaneh-Far R, et al.

Article CAS PubMed PubMed Central Google Scholar Kouli GM, Panagiotakos DB, Kyrou I, Georgousopoulou EN, Chrysohoou C, Tsigos C, et al. Article PubMed Google Scholar Kim SH, Chung JH, Song SW, Jung WS, Lee YAKH. Article PubMed PubMed Central Google Scholar Golan R, Shelef I, Rudich A, et al.

Article CAS PubMed PubMed Central Google Scholar Chen GC, Arthur R, Iyengar NM, et al. Article CAS Google Scholar Saura-Calixto F, Serrano J, Goni I. Article CAS Google Scholar Gepner Y, Shelef I, Schwarzfuchs D, et al.

Article Google Scholar Serino A, Salazar G. Article CAS Google Scholar Tresserra-Rimbau A, Rimm EB, Medina-Remón A, et al. Article CAS PubMed Google Scholar Min SY, Yang H, Seo SG, et al.

Article CAS Google Scholar Xia B, Shi XC, Xie BC, et al. Article CAS PubMed PubMed Central Google Scholar Bettaieb A, Cremonini E, Kang H, Kang J, Haj FG, Oteiza PI. Article CAS PubMed PubMed Central Google Scholar Castro-Barquero S, Lamuela-Raventós RM, Doménech M, Estruch R. Article CAS PubMed Central Google Scholar Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su R, et al.

Article PubMed PubMed Central Google Scholar Siriwardhana N, Kalupahana NS, Cekanova M, LeMieux M, Greer B, Moustaid-Moussa N. Article CAS PubMed Google Scholar Silvester AJ, Aseer KR, Yun JW. Article CAS PubMed Google Scholar Iris S, Dan S, Henkin Y, et al.

Article Google Scholar Schwarzfuchs D, Golan R, Shai I. Article Google Scholar Gepner Y, Golan R, Harman-Boehm I, et al. Article PubMed Google Scholar Yaskolka Meir A, Tsaban G, Zelicha H, et al.

Google Scholar Tsaban G, Yaskolka Meir A, Rinott E, Zelicha H, Kaplan A, Shalev A, et al. Google Scholar Yaskolka Meir A, Rinott E, Tsaban G, et al. Article CAS PubMed Google Scholar Moll R, Davis B. Article Google Scholar Shai I, Rosner BA, Shahar DR, et al. Article CAS PubMed Google Scholar Pereira JM, Sirlin CB, Pinto PS, Casola G.

Article Google Scholar Monzon JR, Basile R, Heneghan S, Udupi V, Green A. Article PubMed Google Scholar Lancerotto L, Stecco C, Macchi V, Porzionato A, Stecco A, De Caro R. PubMed Google Scholar Khan T, Muise E, Iyengar P, et al. Article CAS PubMed Google Scholar Estruch R, Ros E, Salas-Salvado J, et al.

Article CAS PubMed Google Scholar Ahmad S, Demler OV, Sun Q, Moorthy MV, Li C, Lee IM, et al. Article PubMed PubMed Central Google Scholar Salas-Salvadó J, Nica Bulló M, Estruch R, Ros E, Covas M-I, Ria Ibarrola-Jurado N, et al. Article PubMed Google Scholar Guasch-Ferré M, Willett WC.

Article PubMed Google Scholar Barnard ND, Alwarith J, Rembert E, et al. Google Scholar Ristic-Medic D, Kovacic M, Takic M, Arsic A, Petrovic S, Paunovic M, et al. Article PubMed Central Google Scholar Mayr HL, Itsiopoulos C, Tierney AC, et al. Article PubMed Google Scholar Bray GA, Smith SR, de Jonge L, et al.

Article CAS PubMed PubMed Central Google Scholar de Souza RJ, Bray GA, Carey VJ, et al. Article PubMed PubMed Central Google Scholar Maersk M, Belza A, Stodkilde-Jorgensen H, et al.

Article CAS PubMed Google Scholar Shah RV, Murthy VL, Allison MA, et al. Article CAS PubMed Google Scholar Rosqvist F, Iggman D, Kullberg J, et al. Article PubMed Google Scholar Yaskolka Meir A, Tuohy K, von Bergen M, Krajmalnik-Brown R, Heinig U, Zelicha H, et al.

Article PubMed PubMed Central Google Scholar Kaplan A, Zelicha H, Tsaban G, Yaskolka Meir A, Rinott E, Kovsan J, et al. Article PubMed Google Scholar Zelicha H, Kaplan A, Meir AY, Tsaban G, Rinott E, Shelef I, et al. Article CAS PubMed Google Scholar Toney AM, Fox D, Chaidez V, Ramer-Tait AE, Chung S.

Article CAS PubMed PubMed Central Google Scholar Pallister T, Jackson MA, Martin TC, Glastonbury CA, Jennings A, Beaumont M, et al. Article CAS Google Scholar Manach C, Scalbert A, Morand C, Remesy CJL.

Article CAS PubMed Google Scholar Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H, et al. Article Google Scholar Li P, Stuart EA, Allison DB. Article CAS PubMed PubMed Central Google Scholar Benjamini Y, Hochberg Y. Google Scholar Download references. Acknowledgements We thank the DIRECT-PLUS participants for their valuable contributions.

GO BACK. RELATED CONTENT. Share on:. Share on Facebook. Share on Twitter. Share on Linkedin. Share on Email. Tags: Cancer , Epidemiology, Public Health, Cancer Prevention and Palliative Care Program , Nutrition and Cancer ,. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site.

Not consenting or withdrawing consent, may adversely affect certain features and functions. Funcional Funcional Always active The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.

The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.

The technical storage or access that is used exclusively for statistical purposes. The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.

The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.

Accept Deny View preferences Save preferences View preferences. Manage Cookie Consent. Scroll to Top.

YOU CAN STILL ADD MORE!

Nine of the RCTs were done in healthy adults or without cardiometabolic chronic diseases. Only one RCT included subjects with insulin resistance 38 , while another with non-alcoholic fatty liver disease One Canadian RCT 40 combined an initial period of 6-months of isoflavone or placebo supplementation alone, with 6-months of isoflavone or placebo plus PA treatment.

Except one study that did not informed regard the isoflavones type, the others used an isoflavone mixture supplementation genistein, daidzein, glycitein.

Three of them administrated isoflavone supplementation rich in genistein 27 , 37 , 39 , while other three, rich in daidzein 26 , 28 , Participants of 8 studies completed an aerobic exercise or walking program, two a combined program of aerobic and resistance exercise, and one a resistance exercise program.

In addition to PA intervention, one RCT recommended to the participants to follow an energy-balanced diet Also, two Spanish studies instructed their participants to adapt a Mediterranean diet pattern 27 , Detailed characteristics of the studies are presented in Table 2.

Table 2. Characteristics of the studies that combined physical activity with polyphenols. Body weight, BMI, WC, and body fat significantly decreased after both treatments: CRD and CRD-PP Table 3. No differences were observed between both treatments CRD vs.

Table 3. Changes of the outcomes after the intervention with calorie restricted diets and polyphenols. Among the four studies that assessed the effects of isoflavone and reported data for body weight, the Canadian RCT 40 with 12 months of duration showed a significant weight loss after PA-PP treatment but not PA alone Table 4.

Additionally, a study that described the effects of isoflavone in different time-point and reported weight reduce at 6 and 12 months only in the group that received supplementation with isoflavone data not shown Data regarding the effects of isoflavones on BMI were described by six RCTs.

The Canadian RCT 40 , revealed a BMI reduction only in the PA-PP group. Another Spanish RCT 27 with a months duration showed a greater BMI decrease in the PA-PP compared to the PA group. Table 4. Changes of the outcomes after the intervention with physical activity programs and polyphenols.

Isoflavone supplementation plus PA treatment but not PA alone caused a statistically significant total body fat mass loss in two of the RCTs 27 , Moreover, one study reported trunk fat mass loss only in PA-PP group but not in PA alone Two studies that administrated green tea capsule and beverage with small amount of caffeine, did not reported greater results for weight, BMI, WC, and total body fat 42 , Green tea catechins with smaller amount of caffeine plus PA 39 mg caused significant abdominal fat reduce, but not PA treatment alone Twelve of the fifteen selected studied informed about the adverse events due to polyphenols supplementation, while four did not do it 34 , 40 , No adverse events occurred in the rest of the RCTs.

Standardized risk of bias assessment was conducted following these domains: i randomization process; ii deviation from the intended intervention; iii missing outcome data; iv measurement of the outcome; and v selection of the reported studies Table 5.

Three of the RCTs presented a low risk of bias in the five domains 32 , 33 , Statement of randomization was reported, but the randomization method and allocation concealment were not specified in seven studies 28 , 35 , 37 , 38 , 40 , 41 , However, differences between groups at baseline on these studies did not suggest a major problem with the randomization process.

In any case, their bias due to the randomization process was classified at medium risk. Six RCTs did not perform a double-blind design, thus did not fulfill the low risk criteria of deviation from the intended intervention 27 , 34 , 37 , 38 , 41 , Only seven studies were classified at low risk of missing outcome data 28 , 32 — 34 , 36 , 42 , Six of the RCTs did not fulfill the same criteria, mainly for two reasons: i the high rate of drop-outs or loss of follow-up and; ii the lack of an adequate analysis method that correct this bias 27 , 37 — The bias of missing outcome data was not assessed in two studies due to the lack of relevant information for judgment 26 , All studies used objective standardized body composition measures and assessed them properly, thus they were free of bias regarding the measurement of the outcomes.

Selection of the reported results bias was also evaluated at low risk for all included studies. In this review, we have summarized the additional effects of polyphenol supplementation on body weight, BMI, WC, and body fat changes when combined with CRD and PA in adults with overweight or obesity.

Comparing CRD or PA intervention groups with vs. without polyphenols helped to understand how polyphenols affect the efficacy of the CRD or PA on body composition parameters.

The types of polyphenol supplementation were; isoflavone capsule and soybean extract, cocoa extract, grapefruit, and grapefruit juice, epigallocatechin gallate capsule, green tea capsule, and beverage, and resveratrol capsule.

Isoflavone supplementation showed some additional effects in weight and fat loss during PA in overweight or obese postmenopausal women in the non-Asian studies.

No additional effects were indicated for other types of polyphenols during CRD or PA. In addition, these RCTs investigated the effects of polyphenol supplementation on several cardiometabolic parameters related to obesity, showing some protective results on insulin resistance and inflammation markers.

Complementing CRD with one to three months of polyphenol supplementation did not provide any additional effect on weight and fat loss in overweight and obese adults. The results are consistent with findings from a previous review 17 , showing that three months could be insufficient to detect significant polyphenol anti-obesity effects.

CRD triggers adaptive responses by declining energy expenditure, which may persist for at least one year after the weight loss Studies that assessed the effects of polyphenols after diet-induced weight loss found a prevention of weight regain by polyphenols 45 , These findings suggest that polyphenols might be more effective after the dynamic phase of the CRD in order to favor weight maintenance rather than for reducing weight per se during the CRD.

In comparison with CRD, the efficacy of PA was increased in some studies when polyphenols were added. It is important to bear in mind that the number of studies that assessed the effects of isoflavones in this review was larger and had longer duration 6 to 24 months.

Particularly, mixture isoflavone supplementation genistein, daidzein, glycitein enhances the effects of PA aerobic plus resistance exercise on body composition parameters.

Indeed, a higher loss of body weight and fat after PA plus isoflavone was observed compared to PA alone, in postmenopausal women of non-Asian studies 27 , Although, the mean weight loss of 1. Isoflavones are flavonoids found mostly in soy products and are known as phytooestrogene due to their anti- and estrogenic properties.

Adipose tissue express estrogen receptors, therefore, phytoestrogens may affect body composition directly by binding these receptors 48 , then inhibiting lipogenesis and increasing lipolysis Similarly to our findings, in a previous meta-analysis of RCTs phytoestrogens alone including isoflavones showed a significant decrease in body weight in healthy postmenopausal women that received isoflavone mixture supplementations A subsequent meta-analysis in provided higher effectiveness of overall soy products in pre-menopausal women and in overweight or obese Asian participants The last meta-analysis 15 did not analyze the interaction between soy components and body weight which could have provided more insights into the weight-reducing role of each soy components: isoflavones, protein and fiber Soy protein and fiber may confound the effectiveness of isoflavone by increasing satiety Actually, an earlier meta-analysis that performed separate analysis for soy and isoflavones found anti-obesity effect of soy but not for isoflavone Overall, it is difficult to establish the role of isoflavone in weight and fat loss because there are relevant differences between reviews 15 , 50 , 53 regarding the population ethnicity, menopausal and health status, and type and dose of isoflavone supplementation.

A part from weight and fat loss, isoflavone supplementation showed improvement in liver function 26 , inflammation 27 , 37 , and glycemia in women with insulin resistance Although, two of the studies reported some beneficial effects in the fat free mass 28 , 40 , the majority did not observe any modification 26 , 27 , 37 — Blood pressure and lipid profile of healthy women were not affected by isoflavones.

Actually, the cardio-protective potential of isoflavone is stronger in persons with established hypertension 54 or hypercholesteremia Cocoa and its products e.

The addition of 1. From animal studies, it has been suggested that the equivalent dose to a daily amount of 54 g of cocoa powder in human is necessary to have beneficial effects against obesity No additional effects of cocoa occurred in glucose and insulin levels, but beneficial effects were noticed in oxidation status Ibero-Baraibar and coworkers 57 also assessed the effects of cocoa in depression and found a decline of depressive symptoms only in the cocoa group.

This is actually an important finding that could be considered in future cocoa-obesity-related research, as depression and obesity have a bidirectional relationship To our knowledge, few human studies have investigated the implication of grapefruit polyphenols on body weight and fat.

These results are also in accordance with a meta-analysis of three RCTs that reported no influence of grapefruit on body weight The effectiveness of a grapefruit capsule, juice and fruit supplementation on weight has shown to be greater in participants with metabolic syndrome compare to healthy subjects The safety of different forms of grapefruit polyphenols intake at high doses deserves further investigation.

In the RCT by Silver et al. The results of the selected studies in this review were not supportive for any extra anti-obesity effects of green tea polyphenols catechins during CRD treatment.

Diepvens et al. Dulloo et al. Another potential explanation of the null effects of green tea could be the ethnicity of the participants of this review. It has been suggested that green tea may have greater influence in Asian rather than non-Asian participants 62 due to the genetic difference in the catechol O-methyltransferase COMT enzyme Green tea catechins inhibit COMT that degrades norepinephrine, which prolongs the action of sympathetically released norepinephrine, a key mediator to increase energy expenditure and promote the oxidation of fat Caffeine intake is a potential co-factor that should be considered when analyzing green tea activity.

In the RCT of Diepvens et al. The administration of green tea catechins without caffeine could not affect the anthropometric measures The intervention of three months with epigallocatechin-gallate during PA treatment, also, did not result in an additional reduction of weight and fat A meta-analysis of Kapoor et al.

Thus, the relation of epigallocatechin-gallate and body weight, merit prospective research, especially long-term clinical trials. These discrepancies in results indicate that effects of green tea might be more evident in subjects with higher BMI. Incorporating green tea catechins in conventional strategies CRD and PA did not change their effects in glycemia 33 , 41 , 42 , blood pressure 35 , 41 , lipid profile 33 , 41 , 42 , and anti-inflammatory components leptin, adiponectin and C-reactive protein 33 , However, green tea showed a significantly greater decrease of glucose in persons with glucose intolerance 41 , and a higher decline of triglycerides among participants with high triglyceride levels before the intervention Body lean mass was not affected by green tea during PA treatment 41 , One study also reported no influence in exercise performance by considering the changes of oxygen consumption peak VO 2 It is suggested that the improvement of exercise performance by green tea could be attributed, at least partly, to muscle glycogen sparing due to the stimulation of whole-body fat utilization Therefore, this approach have been followed in physically fit subjects and showing an increase of whole-body fat utilization Resveratrol is a stilbene present in the skin of grapes, blueberries, raspberries as well as wine that can improve the metabolic syndrome However, these results 70 presented a large heterogeneity regarding dosage and duration.

Thus, further studies with established doses are warranted for a better comprehension of the anti-obesity potential of resveratrol. Although, weight and fat loss did not reach statistically significance in the Faghihzadeh et al.

Indeed, the current evidence is mostly supportive for the potential liver and cardio-protective effects of resveratrol Our review has some strengths.

Firstly, this is the first review summarizing the additional effects of polyphenol supplementation in addition to a conventional obesity therapy CRD and PA. Secondly, we did not restrict the study selection regarding the gender of participants, their health status, ethnicity, and type of polyphenol supplemented.

We considered these differences during the interpretation of the results and a comprehensive understanding of the overall evidence was reached. However, some limitation should be also considered.

The number of eligible and selected studies was small. Non-English studies were excluded, so we probably missed few studies, especially some Asian RCTs. Furthermore, the body composition parameters were not primary outcomes in all the included RCTs, and therefore, some data was missing. Due to incomplete data and the small number of studies, it was not feasible to perform a meta-analysis.

Moreover, the included studies also presented some methodological drawbacks. Generally, they had a short duration, so the prolonged effects of polyphenols remain unclear. The small number of participants in most of the studies caused a low statistical power to identify significant differences.

The compliance to polyphenol intake among the participants was uncertain in several of the studies. Only two RCTs 32 , 39 measured it by plasma or urine metabolites, five RCTs counted the consumed containers 26 , 34 , 36 , 42 , 43 and eight did not report anything.

Diet and PA outside the study protocol was not controlled in the majority of the RCTs. Moreover, some bias was detected regarding the randomization process, blindness and the missing outcome data bias. The methodological drawbacks should be considered by future researchers to minimize or avoid them.

Findings from this review also suggest that the effects of polyphenols in metabolic parameters might be stronger in patients with already cardiometabolic diseases. Based on the current evidence, the anti-obesity potential of CRD and PA was not improved by adding other types of polyphenols.

There is some evidence suggesting that polyphenols may be more effective in weight maintenance rather than inducing weight loss. Moreover, new RCTs should also focus on investigating the plausible implicated pathways to obesity, such as energy expenditure, fat metabolism, and appetite.

FL and RZ-R contributed to conception and design, screening of the article, data extraction and assessing the quality of the studies. FL wrote the first draft and RZ-R critically revised and edited the manuscript. Both authors read and approved the final manuscript.

ERDF, a way to build Europe. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. RCT, randomized clinical trial; CRD, calorie restricted diet; PA, physical activity; CRD-PP, calorie restricted diet plus polyphenol supplementation; PA-PP, physical activity plus polyphenol supplementation; WC, waist circumference.

Swift DL, Houmard JA, Slentz CA, Kraus WE. Effects of aerobic training with and without weight loss on insulin sensitivity and lipids. PLoS ONE. doi: PubMed Abstract CrossRef Full Text Google Scholar.

Weiss EP, Albert SG, Reeds DN, Kress KS, Mcdaniel JL, Klein S, et al. Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial 1.

Am J Clin Nutr. CrossRef Full Text Google Scholar. Swift DL, Johannsen NM, Lavie CJ, Earnest CP, Blair SN, Church TS. Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations.

Borrell LN, Samuel L. Body mass index categories and mortality risk in US adults: The effect of overweight and obesity on advancing death.

Am J Public Health. Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. Greenway FL. Physiological adaptations to weight loss and factors favouring weight regain. Int J Obes. King NA, Caudwell P, Hopkins M, Byrne NM, Colley R, Hills AP, et al. Narayanaswami V, Dwoskin LP.

Obesity: Current and potential pharmacotherapeutics and targets. Pharmacol Ther. Neff KJ, Olbers T, le Roux CW. Bariatric surgery: the challenges with candidate selection, individualizing treatment and clinical outcomes.

BMC Med. World Health Organization. Obesity and Overweight. Google Scholar. Zamora-Ros R, Guinó E, Henar Alonso M, Vidal C, Barenys M, Soriano A, et al. Dietary flavonoids, lignans and colorectal cancer prognosis. Sci Rep. Zamora-Ros R, Touillaud M, Rothwell JA, Romieu I, Scalbert A.

Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: Current tools and applications and their limits. Guo X, Tresserra-Rimbau A, Estruch R, Martínez-González MA, Medina-Remón A, Fitó M, et al. Polyphenol levels are inversely correlated with body weight and obesity in an elderly population after 5 years of follow up The randomised PREDIMED study.

Jennings A, MacGregor A, Spector T, Cassidy A. Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: Evidence from discordant monozygotic twins. Mu Y, Kou T, Wei B, Lu X, Liu J, Tian H, et al. Soy products ameliorate obesity-related anthropometric indicators in overweight or obese asian and non-menopausal women: A meta-analysis of randomized controlled trials.

Gheflati A, Mohammadi M, Ramezani-Jolfaie N, Heidari Z, Salehi-Abargouei A, Nadjarzadeh A. Does pomegranate consumption affect weight and body composition? A systematic review and meta-analysis of randomized controlled clinical trials. Phyther Res. Farhat G, Drummond S, Al-Dujaili EAS. Polyphenols and their role in obesity management: a systematic review of randomized clinical trials.

Achten J, Jeukendrup AE. Optimizing fat oxidation through exercise and diet. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing h energy expenditure and fat oxidation in humans.

Min SY, Yang H, Seo SG, Shin SH, Chung MY, Kim J, et al. Cocoa polyphenols suppress adipogenesis in vitro and obesity in vivo by targeting insulin receptor. Rupasinghe HPV, Sekhon-Loodu S, Mantso T, Panayiotidis MI. Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss.

Boix-Castejón M, Herranz-López M, Pérez Gago A, Olivares-Vicente M, Caturla N, Roche E, et al. Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: A randomized controlled trial.

Food Funct. Murase T, Haramizu S, Shimotoyodome A, Tokimitsu I. Reduction of diet-induced obesity by a combination of tea-catechin intake and regular swimming. Lambert K, Hokayem M, Thomas C, Fabre O, Cassan C, Bourret A, et al. Combination of nutritional polyphenols supplementation with exercise training counteracts insulin resistance and improves endurance in high-fat diet-induced obese rats.

Shimotoyodome A, Haramizu S, Inaba M, Murase T, Tokimitsu I. Exercise and green tea extract stimulate fat oxidation and prevent obesity in mice. Med Sci Sports Exerc. Barsalani R, Riesco E, Lavoie JM, Dionne IJ.

Effect of exercise training and isoflavones on hepatic steatosis in overweight postmenopausal women. Polyphenols promote a healthy profile of intestinal microbiota, decreasing Firmicutes and increasing Bacteroidetes.

Polyphenols may modulate carbohydrate digestion, glucose absorption and gluconeogenesis, thereby helping contain postprandial hyperglycemic excursions. They improve lipid metabolism by decreasing adipogenesis and inhibiting lipogenesis, and stimulating lipolysis and beta-oxidation.

Polyphenol ingestion was also associated with decreased food-intake and thermogenesis stimulation. Nevertheless, the effects described are still subject to debate because human studies are scarce and some results are inconsistent. Keywords: Absorption , Adipogenesis , Adipose tissue browning , Flavonoids , Food , Food-intake , Lipogenesis , Lipolysis , Metabolism , Microbiota , Polyphenols , Peroxisome proliferator-activated receptor alpha , Peroxisome proliferatoractivated receptor gamma , Sterol regulatory element-binding protein , Obesity , Thermogenesis , Uncoupling protein 1 , Weight loss.

The Relevance of Polyphenols in Obesity Therapy, Recent Advances in Obesity Research Understanding Obesity: From its Causes to Impact on Life 1: The Anatomical Foundations of Regional Anesthesia and Acute Pain Medicine Macroanatomy Microanatomy Sonoanatomy Functional anatomy.

Recent Advances in Obesity Research. Back Understanding Obesity: From its Causes to Impact on Life DOI: Cite as. About this chapter ×. Cite this chapter as: Ana Faria, Cristina Pereira-Wilson, Rita Negrão ; The Relevance of Polyphenols in Obesity Therapy, Recent Advances in Obesity Research Understanding Obesity: From its Causes to Impact on Life 1: Close About this chapter.

Current Diabetes Reviews. Current Neurovascular Research. Current Respiratory Medicine Reviews. Current Pediatric Reviews.

Access this article Increased visceral fat and decreased energy expenditure during the menopausal transition. Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats. Bariatric surgery: the challenges with candidate selection, individualizing treatment and clinical outcomes. Stefan N. Vegetables, fruits, seeds, almonds, and cereals are widely known in diets and supplementations for their enormous benefits on health improving, preventing, and reducing obesity and its RMDs 9 ,
DOI: wejght Polyphenols Fast muscle soreness relief secondary metabolites from plant metabolism, widely distributed in nature. Angiogenesis inhibitors major dietary sources managemnet polyphenols are fruits, vegetables, Fast muscle soreness relief and plant-derived Polyphenolss like weeight, coffee and wine. Polyphenols are mostly Polyphenols and weight management in the small Polyphenoos, extensively and quickly metabolized in the liver and appear in the circulation or are excreted into bile and urine as both intact and metabolized forms. Much attention has been given to polyphenols in the last decades, mainly due to the positive association between the consumption of polyphenol-rich foods and the low risk of chronic diseases like cardiovascular diseases, type 2 diabetes and obesity. In fact, obesity has increased enormously worldwide and is becoming a threat to public health. Several studies suggest that polyphenols and polyphenol-rich foods have very interesting properties regarding the management of obesity and weight loss.

Author: Vudokinos

4 thoughts on “Polyphenols and weight management

Leave a comment

Yours email will be published. Important fields a marked *

Design by ThemesDNA.com