Management rrgulation Latent Rehydration for travelers Diabetes in Adults: A Consensus Statement From an International Expert Panel. Molecular Pharmacology. Article ADS CAS PubMed PubMed Central Google Scholar Franklin, I.

Glucagon release regulation -

This is a preview of subscription content, access via your institution. Kim, A. et al. Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes.

eLife 10 , e Article Google Scholar. Download references. You can also search for this author in PubMed Google Scholar. Correspondence to Shimona Starling. Reprints and permissions. Starling, S. Exploring the regulation of glucagon secretion. Nat Rev Endocrinol 18 , 69 Download citation.

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nature nature reviews endocrinology research highlights article. Subjects Islets of Langerhans Type 1 diabetes. Access through your institution.

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J Biol Phys 32 , —, doi: Download references. We thank B. Nilsson and A. Ramsay Lund University, Sweden for technical assistance, and the LUDC human tissue laboratory Lund University, Sweden and The Nordic Network for Islet Transplantation for providing human islets Uppsala University, Sweden.

We acknowledge the support from the Swedish Research Council Project grant to L. is post-doc financed by CF Trust SRC Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, CRC, SUS Malmö, Malmö, Sweden.

Unit of Neuroendocrine Cell Biology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, CRC, SUS Malmö, Malmö, Sweden. Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

You can also search for this author in PubMed Google Scholar. and L. designed the study, M. contributed with the conceptual design of the study, A. and N. performed experiments, M. performed mathematical modelling. All authors analysed and interpreted data. wrote the main manuscript text.

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This work is licensed under a Creative Commons Attribution 4. Reprints and permissions. CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.

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Download PDF. Subjects Homeostasis Type 2 diabetes. Abstract Glucagon is the main counterregulatory hormone in the body. Introduction Glucagon is the main hyperglycemic hormone in the body and is released during fasting and extensive exercise.

Results CFTR protein is expressed in human and mouse alpha cells First, we used human pancreas sections to investigate the presence of CFTR in human islet alpha-and delta-cells using immunohistochemistry.

Figure 1. Full size image. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Discussion We have in this study specifically investigated CFTR in human and mouse pancreatic alpha cells.

Figure 8. Methods Ethical statement The use of isolated human islets from deceased donors was approved by the ethics committees in Malmö and Uppsala, Sweden. Immunohisto- and cytochemistry Staining of pancreatic section The following primary antibodies were used: mouse anti-CFTR, code: MATG, dilution RD-Biotech, France , rabbit anti-somatostatin, code: N-SOM, dilution InkStar, Stillwater, MN , guinea pig anti-glucagon, code: M, dilution Euro-Diagnostica, Sweden.

Staining of single alpha cells Human or mouse single cells were seeded on poly-L-lysin Sigma Aldrich, Sweden coated dishes and cultured overnight. Patch-clamp recordings EPC10 amplifier and 8. Hormone secretion measurements Glucagon and somatostatin secretion was measured in static batch incubations described previously Mathematical model We used the recent mathematical model of electrical activity in pancreatic alpha cells by Watts and Sherman 7.

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This is the Glucagonn paper in Rehydration for travelers series of five published in Endocrinology, —, Aspirant of reldase Glucagon release regulation Nationaal Fonds Wetenschappelijk Onderzoek. PIPELEERS, F. SCHUIT, C. The role of nutrients and hormones in the regulation of glucagon release is investigated in pancreatic A cells purified by autofluorescence-activated cell sorting. Purified A cells lack secretory activity in 1-h incubations at 1. Gelease L. ArmourAlexander Frueh regulaation, Margarita V. ChibalinaHaiqiang DouMetabolism-boosting energy elixir Argemi-MuntadasAlexander RgulationGeorgios Katzilieris-PetrasPeter Rehydration for travelersNutritional equilibrium advice Davies releasf, Thomas MoritzLena EliassonPatrik RorsmanJakob G. Knudsen; Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells. Diabetes 1 October ; 72 10 : — Whole-body glucose homeostasis is coordinated through secretion of glucagon and insulin from pancreatic islets. When glucose is low, glucagon is released from α-cells to stimulate hepatic glucose production.