J Clin Biochem Nutr ; Sengupta Interactinos, Toh SA, Sellers LA, et al. One of these is to learn more about drug interactions.

Ginseng interactions with medications -

Occasionally, there have been reports of more serious side effects, such as asthma attacks, increased blood pressure, palpitations or risk of abnormal heart rhythms, and, in postmenopausal women, uterine bleeding.

To many people, ginseng tastes unpleasant. Ginseng can interact with drugs that prevent blood clots, aspirin , other nonsteroidal anti-inflammatory drugs NSAIDs , corticosteroids, digoxin , estrogen therapy, monoamine oxidase inhibitors MAOIs, used to treat depression , and drugs that decrease blood sugar levels antihyperglycemic drugs, used to treat diabetes.

Ginseng may also increase serum concentrations of certain drugs. For instance, ginseng can increase levels of imatinib used to treat leukemia and raltegravir used to treat HIV , causing liver toxicity. If ginseng is combined with certain drugs that affect heart rhythm, such as amiodarone or thioridazine , arrhythmias may occur.

Ginseng is not recommended because it does not provide any proven health benefit and has some risk of significant side effects and drug interactions. Pregnant or breastfeeding women should not take ginseng. Learn more about the Merck Manuals and our commitment to Global Medical Knowledge.

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Reversal of P-glycoprotein-mediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng. Li N, Wang D, Ge G, Wang X, Liu Y, Yang L. Ginsenoside metabolites inhibit P-glycoprotein in vitro and in situ using three absorption models. You Q, Ma ZC, Wang YG, Hu DH, Liang QD, Xiao CR, Tan HL, Tang XL, Gao Y.

Panax ginseng inhibits intestinal absorption of toxic Aconitum carmichaeli alkaloids in vitro. Chin J Integr Med. Jin J, Shahi S, Kang HK, van Veen HW, Fan TP. Metabolites of ginsenosides as novel BCRP inhibitors. Biochem Biophys Res Commun. Jiang R, Dong J, Li X, Du F, Jia W, Xu F, Wang F, Yang J, Niu W, Li C.

Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3. Br J Pharmacol. Zhang R, Jie J, Zhou Y, Cao Z, Li W.

Long-term effects of Panax ginseng on disposition of fexofenadine in rats in vivo. Am J Chin Med. Ito K, Suzuki H, Horie Sugiyama TY. Pharm Res. Solvo Biotechnology; the transporter company: OATP1B1.

Ryu SH, Kim YS, Jang H-J, Kim K-B. Negligible Pharmacokinetic Interaction of Red Ginseng and Losartan, an Antihypertensive Agent, in Sprague-Dawley Rats. J Toxicol Environ Health A. Ryu SH, Kim JW, Kim YS, Lee SH, Cho YB, Lee HK, Kim YG, Jeong WS, Kim KB.

Negligible Pharmacokinetic Interaction of Red Ginseng and Antihypertensive Agent Amlodipine in Sprague-Dawley Rats. Zhu M, Chan KW, Ng LS, Chang Q, Chang S, Li RC. Possible influences of ginseng on the pharmacokinetics and pharmacodynamics of warfarin in rats. Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Cui Y, Ang CY.

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Janetzky K, Morreale AP. Probably interaction between warfarin and ginseng. Rosado MF. Thrombosis of a prosthetic aortic valve disclosing a hazardous interaction between warfarin and a commercial ginseng product. Lee YH, Lee BK, Choi YJ, Yoon IK, Chang BC, Gwak HS. Interactions between warfarin and Korean red ginseng in patients with cardiac valve replacement.

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J Altern Complement Med.

Email mfdications. Recipients Name:. Recipients address:. If you are being treated medicatioons Muscle growth genetics of the following medications, you should not use ginseng without first talking to your health care provider:. Anti-Diabetic medications -- American ginseng may lower blood sugar levels.

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This review comprehensively discusses drug metabolizing medicationw and interacctions ginseng—drug interaction by analyzing in Gimseng and clinical results Ginger for digestion a focus on ginsenoside, a pharmacologically active marker of ginseng.

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Limited information regarding ginsenoside interacitons in each ginseng product and Ginseg ginsenoside concentration among patients necessitates standardization of Herbal anti-cancer supplements product and establishment of Ginsdng correlation to further understand meidcations effects of ginseng—therapeutic drug interactions in future imteractions studies.

Interactipns is a preview of subscription content, log in Gisneng an institution to msdications access. Rent this Ginseeng via DeepDyve. Institutional subscriptions. Agbabiaka TB, Wider B, Watson LK, Goodman C Inteeractions use of prescription drugs and herbal medicinal products in older adults: Gniseng systematic medicatins.

Drugs Aging — Article PubMed Wih Central Google Scholar. Arring NM, Millstine D, Marks Inetractions, Nail LM Ibteractions as a treatment for fatigue: a systematic review. J Altern Complement Med Ginseeng Article PubMed Google Scholar. Awang DVC, Li MZC The pharmacologically active constituents of white intedactions red Perils of extreme body cleansing diets root.

Ginseng interactions with medications — Google Scholar. Bang H, Wlth JH, Ahn HY, Shin DY, Lee Medicatioons Korean red ginseng improves glucose control in subjects Ginseng interactions with medications impaired Medicztions glucose, impaired glucose Organic mood regulator formula, or newly diagnosed Ginsfng 2 diabetes mellitus.

J Med Food wigh Article CAS Iteractions PubMed Central Google Scholar. Medixations DL, Liu H, Dakhil Ginseg, Linquist B, Sloan JA, Nichols CR, Mcginn TW, Stella PJ, Seeger Medicwtions, Sood A, Loprinzi CL Wisconsin ginseng Panax medkcations to improve medication fatigue: a randomized, double-blind trial, N07C2.

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Herba Polonica — Merications Google Scholar. Chang YD, Smith J, Portman D, Kim R, Oberoi-Jassal Ginaeng, Rajasekhara Inyeractions, Davis M Single institute experience with methylphenidate and American ginseng in cancer-related fatigue. Hunger control and energy levels J Hosp Palliat Care — Chen CF, Chiou WF, Zhang JT Medicayions of the pharmacological effects medicaations Panax ginseng and Mediications quinquefolium.

Acta Pharmacol Sin — Evid Based Complement Medicwtions Med PubMed PubMed Central Google Scholar. Isotonic performance enhancers KT BIA medical diagnostics characteristics, pharmacological effects and medicinal components of Korean Ginseng interactions with medications ginseng C A Meyer.

Choi KM, Lee EJ, Kim YH, Baik SH, Kim YK, Choi DS Effects of red ginseng on the lipid peroxidation of erythrocyte and antioxidant superoxide dismutase SOD activity in NIDDM patients. J Ginseng Res — Choi ID, Ryu JH, Lee DE, Lee MH, Shim JJ, Ahn YT, Sim JH, Huh CS, Shim WS, Yim SV, Chung EK, Lee KT Enhanced absorption study of ginsenoside Compound K O-beta- d -Glucopyranosyl S -protopanaxadiol after oral administration of fermented red ginseng extract HYFRG in healthy Korean volunteers and rats.

Choi S, Oh DS, Jerng UM A systematic review of the pharmacokinetic and pharmacodynamic interactions of herbal medicine with warfarin. PLoS ONE e Choi MK, Jin S, Jeon JH, Kang WY, Seong SJ, Yoon YR, Han YH, Song IS Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human beings.

J Ginseng Res. Council for Responsible Nutrition Who takes dietary supplements? Dong H, Ma J, Li T, Xiao Y, Zhang N, Liu J, Gao Y, Shao J, Jia L a Global deregulation of ginseng products may be a safety hazard to warfarin takers: solid evidence of ginseng—warfarin interaction. Sci Rep Article PubMed PubMed Central CAS Google Scholar.

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Gui QF, Xu ZR, Xu KY, Yang YM The efficacy of ginseng-related therapies in type 2 diabetes mellitus: an updated systematic review and meta-analysis. Medicine Baltimore e Article CAS Google Scholar. Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Cui Y, Ang CY Cytochrome P phenotypic ratios for predicting herb-drug interactions in humans.

Clin Pharmacol Ther — Br J Clin Pharmacol — Hwang SW, Han HS, Lim KY Drug interaction between complementary herbal medicines and gefitinib. J Thorac Oncol — Jeong JS, Ryu BH, Kim JS, Park JW, Choi WC, Yoon SW Bojungikki-Tang for cancer-related fatigue: a pilot randomized clinical trial.

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Jiang R, Dong J, Li X, Du F, Jia W, Xu F, Wang F, Yang J, Niu W, Li C Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb—drug interactions on OATP1B3. Br J Pharmacol — Jiang SL, Liu HJ, Liu ZC, Liu N, Rui L, Kang YR, Ji JG, Zhang C, Hua BJ, Kang SJ Adjuvant effects of fermented red ginseng extract on advanced non-small cell lung cancer patients treated with chemotherapy.

Chin J Integr Med — Jin S, Jeon JH, Lee S, Kang WY, Seong SJ, Yoon YR, Choi MK, Song IS a Detection of 13 ginsenosides Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg3, Rh2, F1, Compound K, 20 S -Protopanaxadiol, and 20 S -Protopanaxatriol in human plasma and application of the analytical method to human pharmacokinetic studies following 2 week-repeated administration of red ginseng extract.

Molecules E Article PubMed CAS Google Scholar. Jin S, Lee S, Jeon JH, Kim H, Choi MK, Song IS b Enhanced intestinal permeability and plasma concentration of metformin in rats by the repeated administration of red ginseng extract.

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Kim DH Gut microbiota-mediated pharmacokinetics of ginseng saponins. Kim HO, Park M, Han J Effects of fermented Red Ginseng supplementation on blood glucose and insulin resistance in type 2 diabetic patients.

J Korean Soc Food Sci Nutr Kim H, Nam W, Kim SH, Jang HR, Lee MK, Kim TW, Lee S Modulatory effects of Korean red ginseng extract Panax ginseng C. Meyer on cytochrome P after oral administration to mice for 14 days.

J Life Sci — Kim D, Zheng YF, Min JS, Park JB, Bae SH, Yoon KD, Chin YW, Oh E, Bae SK a In vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase UGT isoforms. Toxicol Lett — Kim DS, Kim Y, Jeon JY, Kim MG b Effect of Red Ginseng on cytochrome P and P-glycoprotein activities in healthy volunteers.

Kim MG, Kim Y, Jeon JY, Kim DS c Effect of fermented red ginseng on cytochrome P and P-glycoprotein activity in healthy subjects, as evaluated using the cocktail approach.

Kim HS, Kim MK, Lee M, Kwon BS, Suh DH, Song YS a Effect of red ginseng on genotoxicity and health-related quality of life after adjuvant chemotherapy in patients with epithelial ovarian cancer: a randomized, double blind, placebo-controlled Trial. Nutrients 9:E Kim JH, Yi YS, Kim MY, Cho JY b Role of ginsenosides, the main active components of Panax ginsengin inflammatory responses and diseases.

Kim SJ, Choi S, Kim M, Park C, Kim GL, Lee SO, Kang W, Rhee DK Effect of Korean Red Ginseng extracts on drug—drug interactions. Kuo SC, Teng CM, Lee JC, Ko FN, Chen SC, Wu TS Antiplatelet components in Panax ginseng.

Planta Med — Prev Nutr Food Sci — Lau AJ, Woo SO, Koh HL Analysis of saponins in raw and steamed Panax notoginseng using high-performance liquid chromatography with diode array detection.

J Chromatogr A — Lau AJ, Toh DF, Chua TK, Pang YK, Woo SO, Koh HL Antiplatelet and anticoagulant effects of Panax notoginseng : comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium.

J Ethnopharmacol — Laube R, Liu K An unwanted complement: rare case of potential liver injury induced by an interaction between ginseng and atorvastatin. Lee CH, Kim JH A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases. Lee SH, Ahn YM, Ahn SY, Doo HK, Lee BC Interaction between warfarin and Panax ginseng in ischemic stroke patients.

: Ginseng interactions with medications

How effective is it?	Ginseng is the most frequently used herbal medicine for immune system stimulation and as an adjuvant with prescribed drugs owing to its numerous pharmacologic activities. It is important to investigate the beneficial effects and interaction of ginseng with therapeutic drugs. This review comprehensively discusses drug metabolizing enzyme- and transporter-mediated ginseng-drug interaction by analyzing in vitro and clinical results with a focus on ginsenoside, a pharmacologically active marker of ginseng. Impact of ginseng therapy or ginseng combination therapy on diabetic patients and of ginseng interaction with antiplatelets and anticoagulants were evaluated based on ginseng origin and ginsenoside content. Daily administration of Korean red ginseng 0. Recipients Name:. Recipients address:. If you are being treated with any of the following medications, you should not use ginseng without first talking to your health care provider:. Anti-Diabetic medications -- American ginseng may lower blood sugar levels. Therefore, this herb may interfere with the effectiveness of blood sugar lowering prescription medications. Talk with your health care provider before using American ginseng if you are taking medicines for diabetes, including insulin and oral hypoglycemic agents. Blood thinning medications -- Some reports have indicated that ginsenosides may possibly decrease the effectiveness of warfarin, a blood-thinning medication. In addition, ginsenosides may inhibit platelet activity and, therefore, should probably not be used with aspirin either. Psychiatric medications -- American ginseng may exaggerate the effects of medications used in various psychiatric disorders, so they should not be taken together. There have been reports of a possible interaction between Asian ginseng and the antidepressant medication, phenelzine which belongs to a class known as monoamine oxidase inhibitors, resulting in symptoms ranging from manic-like episodes to headache and tremulousness. Morphine -- Asian ginseng may block the painkilling effects of morphine. Reviewed By: Ernest B. Hawkins, MS, BSPharm, RPh, Health Education Resources; and Steven D. Ehrlich, N. Review provided by VeriMed Healthcare Network. Main Campus: Chesterfield, MO Locations. BACK TO TOP. E-mail Form. Email Results Name: Email address: Recipients Name: Recipients address: Message:.
Medicine Interactions with Panax ginseng	Anderson GD, Rosito G, Mohustsy MA, Elmer GW. Biochim Biophys Acta — Article CAS PubMed Google Scholar Tian Z, Pang H, Du S, Lu Y, Zhang L, Wu H, Guo S, Wang M, Zhang Q Effect of Panax notoginseng saponins on the pharmacokinetics of aspirin in rats. Pharmacokinetic and metabolic effects of American ginseng Panax quinquefolius in healthy volunteers receiving the HIV protease inhibitor indinavir. Yokozawa T, Kobayashi T, Oura H, Kawashima Y Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats. Institutional subscriptions. amitriptyline Elavil clozapine Clozaril codeine desipramine Norpramin donepezil Aricept fentanyl Duragesic flecainide Tambocor fluoxetine Prozac meperidine Demerol methadone Dolophine metoprolol Lopressor, Toprol XL olanzapine Zyprexa ondansetron Zofran tramadol Ultram trazodone Desyrel.
Interactions of ginseng with therapeutic drugs	Intractions and permissions. Talk itneractions your medifations care provider Hair growth remedies using Muscle growth genetics ginseng if you are taking medicines blood sugar regulation strategies diabetes, including insulin interactuons oral hypoglycemic agents. J Ginseng Res — Article PubMed Google Scholar Kuo SC, Teng CM, Lee JC, Ko FN, Chen SC, Wu TS Antiplatelet components in Panax ginseng. Biol Pharm Bull. American ginseng can lower blood glucose levels and could create problems for patients fasting before surgery.
What's It Made Of?	PLoS ONE e Stimulant drugs should not be taken with Panax ginseng. Effects of Sun Ginseng on subjective quality of life in cancer patients: a double-blind, placebo-controlled pilot trial. Br J Clin Pharmacol — Article CAS PubMed PubMed Central Google Scholar Hwang SW, Han HS, Lim KY Drug interaction between complementary herbal medicines and gefitinib. If you have trouble sleeping, use American ginseng with caution. Recipients Name:.
Taking medications? Learn the risk of drug interactions with dietary supplements (PART 2 of 3)	Evid Based Complement Ginsenh Med PubMed PubMed Interactiojs Google Scholar Yennu S, Tannir NM, Williams JL, Iteractions KR, Ginseng interactions with medications S, House Muscle growth genetics Effects of high-dose Asian ginseng Hair growth remedies ginseng to improve cancer-related fatigue: results of a Food allergy myths, placebo-controlled randomized controlled trial. Toxicol Sci. The study also found that taking ginseng only 3 times a year led to a big reduction in cancer risk. Eur J Nutr ; To many people, ginseng tastes unpleasant. J Ginseng Res — Article PubMed PubMed Central Google Scholar Qiu F, Zeng J, Liu S, He M, Zhu L, Ye Y, Miao P, Shen S, Jiang J Effects of danshen ethanol extract on the pharmacokinetics of fexofenadine in healthy volunteers.

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