Organic conscious living anti-inflammatory and Anx properties of Pycnogenol ® further contribute to the versatile nature of Pycnogenol® on body health and Optimize exercise recovery. French Pycnogenol and blood circulation pine bark bloos significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Maritime Pine. Panminerva Med. A multitude of studies about Pycnogenol and sports nutrition have been conducted. Hadi A, Pourmasoumi M, Mohammadi H, Javaheri A, Rouhani MH.

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Pycnogenol® and the circulatory system

Pycnogenol and blood circulation -

Further to its arterial benefits, Pycnogenol also significantly improves the health of veins. It has a year track record of clinical research devoted specifically to vein health. In a total of participants, Pycnogenol has been shown in 15 clinical trials to reduce swellings and improve circulation.

With increasing age, our fragile blood capillaries become less able to cope with gravity; as such, watery fluids leak into the cavities or tissues of the body — mostly in the feet and lower legs — causing an oedema or swelling to occur.

Pycnogenol has repeatedly demonstrated its ability in various trials to strengthen fragile capillaries, efficiently counteracting lower limb swelling and making it a lot easier for affected people to put their shoes on!

Accelerated ageing is commonly associated with persistent, stealthy inflammatory processes and oxidative stress in the body. In several controlled studies, the inflammation prevention properties of Pycnogenol have been demonstrated in women in particular. Ladies experiencing menstrual discomfort and pain were found to significantly benefit from Pycnogenol supplementation; the results from four clinical trials reported decreased cramp-related pain and a marked reduction in the need to take analgesic medication.

Furthermore, continuous daily supplementation with Pycnogenol has been credited with reducing the symptoms of endometriosis in 58 women.

The inflammation causes discomfort, which is often treated with non-steroidal pain medications. This enables better mobility … but does so at the expense of accelerating joint health deterioration. Clinical research has demonstrated that Pycnogenol metabolites specifically reach human joints, effectively arresting inflammation, the prerequisite for the recovery of cartilage integrity.

Indeed, Pycnogenol proved to be efficacious for joint health improvement in three double-blind research projects. Once consumed, Pycnogenol is processed by the gut microbiota to produce specific, bioactive metabolites that share the same distribution privileges as glucose and vitamin C in the body.

It is for this reason that Pycnogenol is so versatile and associated with so many health benefits; it reaches a vast range of organs and tissues, including the brain. Correspondingly, Pycnogenol has repeatedly demonstrated its ability to improve cognitive function in both healthy students and senior citizens.

Home Ingredients Pycnogenol: a pioneer of age defiance. Figure 3: Pycnogenol is known to inhibit NF-kB activation In several controlled studies, the inflammation prevention properties of Pycnogenol have been demonstrated in women in particular.

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Benign prostatic hypertrophy: Pycnogenol supplementation improves prostate symptoms and residual bladder volume. Minerva Med. Hu S, Belcaro G, Ledda A, et al. Behçet syndrome: effects of Pycnogenol supplementation during regression phases.

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Pycnogenol and centella asiatica for asymptomatic atherosclerosis progression. Int Angiol. Ikuyama S, Fan B, Gu J, Mukae K, Watanabe H.

Molecular mechanism of intracellular lipid accumulation: suppressive effect of Pycnogenol in liver cells. Improvement in symptoms and cochlear flow with Pycnogenol in patients with Meniere's disease and tinnitus.

Belcaro G, Cesarone R, Steigerwalt J, et al. Jet-lag: prevention with Pycnogenol. Preliminary report: evaluation in healthy individuals and in hypertensive patients.

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Pycnogenol improves cognitive function, attention, mental performance and specific professional skills in healthy professionals aged Sarikaki V, Rallis M, Tanojo H, et al. In vitro percutaneous absorption of pine bark extract Pycnogenol in human skin. J Toxicol ; Luzzi R, Belcaro G, Hosoi M, et al.

Normalization of cardiovascular risk factors in pre-menopausal women with Pycnogenol. Valls RM, Llaurado E, Fernandez-Castillo S, et al. Effects of low molecular weight procyanidin rich extract from French maritime bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: randomized, double-blind, crossover, placebo-controlled intervention trial.

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Pycnogenol and centella asiatica to prevent asymptomatic atherosclerosis progression in clinical events. Taxon: Pinus pinaster Aiton.

National Plant Germplasm System. Accessed May 29, Vinciguerra G, Belcaro G, Bonanni E, et al. Evaluation of the effects of supplementation with Pycnogenol on fitness in normal subjects with the Army Physical Fitness Test and in performances of athletes in the minute triathlon.

J Sports Med Phys Fitness ; Sahebkar A. A systematic review and meta-analysis of the effects of pycnogenol on plasma lipids. J Cardiovasc Pharmacol Ther ; Khurana H, Pandey RK, Saksena AK, Kumar A.

An evaluation of vitamin E and pycnogenol in children suffering from oral mucositis during cancer chemotherapy. Oral Dis ; Bottari A, Belcaro G, Ledda A, et al.

Lady Prelox improves sexual function in generally healthy women of reproductive age. Minerva Ginecol ; Belcaro G, Shu H, Luzzi R, et al. Improvement of common cold with Pycnogenol: a winter registry study.

Belcaro G, Dugall M, Luzzi R, Hosoi M, Corsi M. Improvements of venous tone with pycnogenol in chronic venous insufficiency: an ex vivo study on venous segments. Int J Angiol ; Belcaro G, Cornelli U, Luzzi R, et al. Pycnogenol supplementation improves health risk factors in subjects with metabolic syndrome.

Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress-a concise review. Saudi Pharma J Maritim AC, Sanders RA, Watkins JB 3rd. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol ; Farid R, Mirfeizi Z Mirheidari M Z Rezaieyazdi Mansouri H Esmaelli H.

Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research ; Roseff SJ, Gulati R. Improvement of sperm quality by pycnogenol.

Eur Bull Drug Res ; Durackova, B. Trebatický V. Novotný I. Žit®anová J. Lipid metabolism and erectile function improvement by Pycnogenol®, extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction - a pilot study. Hosseini S, Pishnamazi S Sadrzadeh SMH Farid F Farid R Watson RR.

Pycnogenol in the management of asthma. J Medicinal Food ; Durackova, Z. Lipid metabolism and erectile dysfunction improvement by Pycnogenol R , extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction -- a pilot study.

Kohama T, Negami M. Effect of Low-dose French Maritime Pine Bark Extract on Climacteric Syndrome in Perimenopausal Women: A Randomized, Double-blind, Placebo-controlled Trial.

J Reproductive Med ; Schmidtke I, Schoop W. Pycnogenol: stasis oedema and its medical treatment. Schweizerische Zeitschrift fur GanzheitsMedizin ; Hosseini, S. A randomized, double blind, placebo controlled, prospective 16 week crossover study to determine the role of Pycnogenol R in modifying blood pressure in mildly hypertensive patients.

Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases.

Wei, Z. Pycnogenol enhances endothelial cell antioxidant defenses. Redox Report ; Virgili, F. Procyanidins extracted from Pinus maritima Pycnogenol : scavengers of free radical species and modulators of nitrogen monoxide metabolism in activated murine RAW Free Radic.

Biol Med ;24 Macrides, T. A comparison of the hydroxyl radical scavenging properties of the shark bile steroid 5 beta-scymnol and plant pycnogenols. Biochem Mol Biol Int ; Noda, Y. Hydroxyl and superoxide anion radical scavenging activities of natural source antioxidants using the computerized JES-FR30 ESR spectrometer system.

Furumura, M. Oral administration of French maritime pine bark extract Flavangenol R improves clinical symptoms in photoaged facial skin. Aging ; Perera, N. Phlebotonics for haemorrhoids. Schoonees, A.

Pycnogenol R extract of French maritime pine bark for the treatment of chronic disorders. Pycnogenol R for the treatment of chronic disorders. Marini, A. Pycnogenol R effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women.

Skin Pharmacol. Physiol ; Mach, J. Enseleit, F. Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study.

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Errichi, B. Prevention of post thrombotic syndrome with Pycnogenol R in a twelve month study. Aoki, H. Clinical assessment of a supplement of Pycnogenol R and L-arginine in Japanese patients with mild to moderate erectile dysfunction.

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Grossi, M. Improvement in cochlear flow with Pycnogenol R in patients with tinnitus: a pilot evaluation. Stuard, S. Kidney function in metabolic syndrome may be improved with Pycnogenol R.

Cesarone, M. Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants--a controlled study.

Pycnogenol treatment of acute hemorrhoidal episodes. Steigerwalt, R. Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy. Daily consumption of Reliv Glucaffect for 8 weeks significantly lowered blood glucose and body weight in 50 subjects.

Rucklidge, J. Nutrient supplementation approaches in the treatment of ADHD. Zibadi, S. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation.

Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol. Ryan, J. An examination of the effects of the antioxidant Pycnogenol on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population.

J Psychopharmacol. Cisar, P. Effect of pine bark extract Pycnogenol on symptoms of knee osteoarthritis. Suzuki, N. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study.

J Reprod. Treatment of osteoarthritis with Pycnogenol. The SVOS San Valentino Osteo-arthrosis Study. Evaluation of signs, symptoms, physical performance and vascular aspects. Urinary catecholamines in children with attention deficit hyperactivity disorder ADHD : modulation by a polyphenolic extract from pine bark pycnogenol.

Nikolova, V. Sofiia ; Angiology ; Chovanova, Z. Res ; The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder ADHD.

Voss, P. Ferritin oxidation and proteasomal degradation: protection by antioxidants. Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol. Ahn, J. Effects of plant extracts on microbial growth, color change, and lipid oxidation in cooked beef.

Food Microbiol. Grimm, T. Single and multiple dose pharmacokinetics of maritime pine bark extract pycnogenol after oral administration to healthy volunteers. Clin Pharmacol ; Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study.

Clin Appl Thromb. Trebaticka, J. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Child Adolesc. Psychiatry ; Chayasirisobhon, S. Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication.

Headache ; Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract Pycnogenol.

J Inflamm. Lond ; Schafer, A. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract Pycnogenol. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol.

Baumann, L. How to prevent photoaging? J Invest Dermatol. Torras, M. Antimicrobial activity of Pycnogenol. Thornfeldt, C. Cosmeceuticals containing herbs: fact, fiction, and future.

Prevention of edema in long flights with Pycnogenol. Clin Appl. Huang, W. Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL cells. Segger, D. and Schonlau, F. Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women.

J Dermatolog. Mochizuki, M. and Hasegawa, N. Pycnogenol stimulates lipolysis in 3t3-L1 cells via stimulation of beta-receptor mediated activity. Therapeutic efficacy of pycnogenol in experimental inflammatory bowel diseases. Dene, B.

Effects of antioxidant treatment on normal and diabetic rat retinal enzyme activities. J Ocul. Pharmacol Ther ; Berryman, A. Influence of treatment of diabetic rats with combinations of pycnogenol, beta-carotene, and alpha-lipoic acid on parameters of oxidative stress. Nelson, A. Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical-induced DNA damage.

Drug Dev. Ind Pharm ; Kim, Y. and Park, H. The effects of Pycnogenol on DNA damage in vitro and expression of superoxide dismutase and HP1 in Escherichia coli SOD and catalase deficient mutant cells.

Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Siler-Marsiglio, K. Protective mechanisms of pycnogenol in ethanol-insulted cerebellar granule cells.

J Neurobiol. Antimicrobial and antioxidant activities of natural extracts in vitro and in ground beef. J Food Prot. Liu, X. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients.

Life Sci ; Zhang, D. Pycnogenol in cigarette filters scavenges free radicals and reduces mutagenicity and toxicity of tobacco smoke in vivo. Toxicol Ind Health ; Maritim, A. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats.

Pycnogenol R in the Management of Asthma. J Med Food ; Sharma, S. Pycnogenol inhibits the release of histamine from mast cells. Devaraj, S. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile.

Lipids ;

Each of its compounds provides a bloov way of acting Pycnogenll the body. Some of the larger molecules get further processed in the gut into metabolites. Consequently, Pycnohenol offers a comprehensive Cieculation of active compounds, distinguishing it from Organic conscious living Pynogenol. Pycnogenol and blood circulation key properties of Pycnogenol on the body are its powerful antioxidant actions, its natural anti-inflammatory benefits, its effects on the skin and tissues and its support for blood circulation Figure 1. Collectively, these mechanisms account for the extensive range of applications that Pycnogenol holds in the realms of health and beauty. Ongoing research will continue to unveil further insights and potentially discover additional applications for the effects of Pycnogenol. Pycnogenol improves blood circulation Keeping the cardiovascular system healthy is key to maintaining good vitality, physical strength, mental health and for general well-being. The ageing process often Pycnogenok unnoticed Pydnogenol our bodies until a certain point is reached when we realise that the Dental plaque in our Pycnogenop joints no longer fades and reoccurs at regular blooc Organic conscious living but persists, and our formerly Organic conscious living forgetfulness circultaion mutated Pyccnogenol an andd and Organic conscious living memory circlation. A healthy diet and regular exercise circulatiion the foundation stones for staying healthy longer. And, fortunately, clinical research during the past 30 years has revealed that specific dietary components may verifiably restore some age-associated impairments, both physical and mental. Early Pycnogenol research pointed to significant cardiovascular health applications, such as improving vein health, relieving oedema and releasing arterial constrictions Figure 1. Pycnogenol acts as a catalyst in the endothelium — the tissues surrounding blood vessels — to more efficiently generate nitric oxide, an important mediator involved in relaxing the smooth muscles around the arteries. With increasing arterial relaxation, a smoother blood flow is achieved, together with a healthier blood pressure. Nitric oxide further normalises blood platelet activity, and Pycnogenol was correspondingly demonstrated to help prevent blood platelet aggregation in the absence of injuries.