Quercetin and anti-fungal properties -
Med Chem Res ; 21 9 : Antifungal activity of phenolic compounds identified in flowers from North Eastern Portugal against Candida species. Future Microbiol ; 9 2 : Quercetin assists fluconazole to inhibit biofilm formations of fluconazole-resistant Candida albicans in in vitro and in vivo antifungal managements of vulvovaginal candidiasis.
Cell Physiol Biochem ; 40 : Quercetin and rutin as potential agents antifungal against Cryptococcus spp. Braz J Biol ; 76 4 : Genetic characterisation of Botrytis cinerea populations in Chile. Mycol Res ; 5 : Antifungal effects of the flavonoids kaempferol and quercetin: A possible alternative for the control of fungal biofilms.
Biofouling ; 35 3 : Quercetin impairs Streptococcus pneumoniae biofilm formation by inhibiting sortase A activity. J Cell Mol Med ; 22 12 : Anti-biofilm and cytoprotective activities of quercetin against Pseudomonas aeruginosa isolates.
Lett Appl Microbiol ; 68 5 : Antibacterial and antibiofilm activities of quercetin against clinical isolates of Staphyloccocus aureus and Staphylococcus saprophyticus with resistance profile.
Int J Environ Agric Biotech ; 3 5 : Anti-biofilm activities of quercetin and tannic acid against Staphylococcus aureus. Biofouling ; 29 5 : Biosynthesis, characterization of silver nanoparticles using quercetin from Clitoria ternatea L to enhance toxicity against bacterial biofilm.
J Inorg Organomet Polym Mater ; 27 5 : Quercetin and its anti-allergic immune response. Molecules ; 21 5 : Anti-allergic effects of enzymatically modified isoquercitrin -oligoglucosyl quercetin 3-O-glucoside , quercetin 3-O-glucoside, -oligoglucosyl rutin, and quercetin, when administered orally to mice.
J Nat Med ; 67 4 : J Funct Foods ; in vivo anti-inflammatory and antiallergic activity of pure naringenin, naringenin chalcone, and quercetin in mice. J Nat Prod ; 82 2 : Synergistic antiproliferative activity of quercetin and cisplatin on ovarian cancer cell growth.
Anticancer Drugs ; 1 1 : Synergistic effect of apple extracts and quercetin 3-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancer cells in vitro. J Agric Food Chem ; 57 18 : Type II estrogen binding sites and antiproliferative activity of quercetin in human meningiomas.
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Br J Haematol ; 79 4 : Volume: 18 Issue: 5. Affiliation: Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India. Abstract: The present review aims to describe an overview of quercetin with its various pharmacological effects.
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Food Res Int. Download references. Department of Chromatography, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, Pl. Maria Curie Sklodowska 3, , Lublin, Poland. Department of Synthesis and Technology, Institute of Industrial Organic Chemistry, 6 Annopol St.
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Reprints and permissions. Wianowska, D. A Central Composite Design in increasing the quercetin content in the aqueous onion waste isolates with antifungal and antioxidant properties. Eur Food Res Technol , — Download citation. Received : 16 June Revised : 21 October Accepted : 23 October Published : 05 November Issue Date : February Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Download PDF. Abstract In this study, to increase the content of quercetin in the isolates obtained from the white and red onion scales, in accordance with the zero waste philosophy, using water as an environmentally and healthy friendly extractant, a mathematical model was constructed, based on the Central Composite Design.
A Comparative Evaluation of Aqueous Natural Organic Acid Media for the Efficient Recovery of Flavonoids from Red Grape Vitis vinifera Pomace Article 11 March Phytochemical properties in the waste by-products of peach: optimization and storage stability studies Article 04 August Optimization of microwave-assisted extraction of antioxidant compounds from spring onion leaves using Box—Behnken design Article Open access 10 September Use our pre-submission checklist Avoid common mistakes on your manuscript.
Introduction Nowadays, an evident increase in the demand for biologically active natural products and the interest in more ecological and environmentally friendly methods of obtaining them are observed.
Materials and methods Plant material The representative portions of white and red onions purchased from a local market were hand peeled to obtain the inedible outer scales of the onion. Pressurized hot water extraction Extractions were performed in a dynamic mode using the hand-made PHWE system described in detail in [ 18 ] on weighed portions of onion scales 0.
HPLC analysis HPLC measurements were performed with a Dionex liquid chromatograph DX Dionex Corp. Antioxidant activity The antioxidant activity of extracts obtained under the optimal PHWE conditions was assessed using the three spectrophotometric methods presented below.
β-carotene bleaching assay The test was performed according to the method described in [ 19 ]. ABTS method The determination was made in accordance with [ 21 ]. Antifungal activity The activities of the extracts against B. Experimental design and statistical analysis A statistical experimental based on Central Composite Design and Statistica10 software StaSoft, Inc.
Table 1 Central Composite Design arrangement, responses, and predicted values for the quercetin yield from the white and red onion scales Full size table. Table 2 Analysis of variance for the second-order polynomial model estimated for the quercetin yield obtained from the white and red onion scales using PHWE Full size table.
Full size image. Conclusions The annual world onion production is over 80 million tons. References Slimestad R, Fossen T, Vågen IM Onions: a source of unique dietary flavonoids.
x Article Google Scholar Katsampa P, Valsamedou E, Grigorakis S, Makris DP A green ultrasound-assisted extraction process for the recovery of antioxidant polyphenols and pigments from onion solid wastes using Box-Behnken experimental design and kinetics.
J Food Nutr Res —26 CAS Google Scholar Roldán-Marín E, Sánchez-Moreno C, Lloría R, de Ancos B, Cano MP Onion high-pressure processing: flavonol content and antioxidant activity. Funding The authors did not receive support from any organization for the submitted work. Author information Authors and Affiliations Department of Chromatography, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, Pl.
View author publications. Colunga Biancatelli RML et al Quercetin and vitamin C: an experimental, synergistic therapy for the prevention and treatment of SARS-CoV-2 related disease COVID Front Immunol Boudiaf F et al Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats.
J Anim Behav Biometeorol 8 3 — Sharma G et al Anti-diabetic, anti-oxidant and anti-adipogenic potential of quercetin rich ethyl acetate fraction of Prunus persica. Pharmacognosy J 10 3. Hisaka T et al Quercetin suppresses proliferation of liver cancer cell lines in vitro. Anticancer Res 40 8 — Zhou J et al Investigation of the anti-cancer effect of quercetin on HepG2 cells in vivo.
PLoS ONE 12 3 :e Guan F et al Anti-rheumatic effect of quercetin and recent developments in nano formulation. RSC Adv 11 13 — Shastrala K et al Synthesis, characterization, and pharmacological evaluation of some metal complexes of quercetin as P-gp inhibitors.
Future J Pharm Sci 7 1 :1— Nathiya S. Batiha GES et al The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin.
Foods 9 3 Li Y et al Quercetin, inflammation and immunity. Nutrients 8 3 Wang J et al Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro.
J Ovarian Res 11 1 :1— Suematsu, N. Hosoda, and K. Fujimori, Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells. Lesjak M et al Antioxidant and anti-inflammatory activities of quercetin and its derivatives.
J Funct Foods — Zheng Y-Z et al Antioxidant activity of quercetin and its glucosides from propolis: a theoretical study.
Sci Rep 7 1 :1— Pahal V, Devi U, Dadhich KS, Quercetin, a secondary metabolite present in methanolic extract of Calendula officinalis, is a potent inhibitor of peptide deformylase, undecaprenyl pyrophosphate synthase and DNA primase enzymes of Staphylococcus aureus: an in vitro and in silico result analysis.
pp — da Costa Júnior SD et al Antibacterial and antibiofilm activities of quercetin against clinical isolates of Staphyloccocus aureus and Staphylococcus saprophyticus with resistance profile.
Int J Environ Agric Biotechnol 3 5 Adamczak A, Ożarowski M, Karpiński TMJJOCM Antibacterial activity of some flavonoids and organic acids widely distributed in plants. J Clin Med 9 1 Li F et al The simultaneous loading of catechin and quercetin on chitosan-based nanoparticles as effective antioxidant and antibacterial agent.
Food Res Int — Sarangapani S, Jayachitra AJFFIH Targeting biofilm inhibition using quercetin-interaction with bacterial cell membrane and ROS mediated biofilm control.
Funct Foods Health Dis 8 6 — Gao M et al Quercetin assists fluconazole to inhibit biofilm formations of fluconazole-resistant Candida albicans in in vitro and in vivo antifungal managements of vulvovaginal candidiasis. Cell Physiol Biochem 40 3—4 — Rocha MFG et al Antifungal effects of the flavonoids kaempferol and quercetin: a possible alternative for the control of fungal biofilms.
Biofouling 35 3 — Shishodia SK et al SEM and qRT-PCR revealed quercetin inhibits morphogenesis of Aspergillus flavus conidia via modulating calcineurin-Crz1 signalling pathway. Mycology 11 2 — Oliveira V et al Quercetin and rutin as potential agents antifungal against Cryptococcus spp.
Br J Biol — Milanezi FG et al Antioxidant, antimicrobial and cytotoxic activities of gold nanoparticles capped with quercetin.
Saudi Pharm J 27 7 — Dewi B, et al Effectivity of quercetin as antiviral to dengue virus-2 strain New Guinea C in Huh 7-it 1 cell line. In: IOP conference series: earth and environmental science. IOP Publishing.
Rojas Á et al Effect of quercetin on hepatitis C virus life cycle: from viral to host targets. Sci Rep 6 1 :1—9. Wong G et al Antiviral activity of quercetinβ-OD-glucoside against Zika virus infection. Virol Sin 32 6 — Di Pierro F et al Potential clinical benefits of quercetin in the early stage of COVID results of a second.
Pilot Randomized Control Open-Label Clin Trial Wu W et al Quercetin as an antiviral agent inhibits influenza A virus IAV entry. Viruses 8 1 Shaikhomar OA, Bahattab OSJSJBR Physiological Effect of Quercetin as a Natural Flavonoid to be used as Hypoglycemic Agent in Diabetes Mellitus Type II Rats.
Saudi J Biomed Res 6 1 — Hemmati M, et al. Modern Care J. Artif Cells Nanomed Biotechnol 46 3 :S—S Abu Ayana MA et al Efficacy of quercetin on alveolar bone structure of rats with induced diabetes.
Alex Dent J 42 2 — Lei C-S et al Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies.
J Nutr Biochem — Liu H et al Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice. Obstet Gynecol Sci 62 4 — Xu G et al Enhancing the anti-ovarian cancer activity of quercetin using a self-assembling micelle and thermosensitive hydrogel drug delivery system.
RSC Adv 8 38 — Shen Y, TanTai JJDD Development, and therapy, co-delivery anticancer drug nanoparticles for synergistic therapy against lung Cancer Cells.
Drug Des Dev Therapy Karliana D, Anwar E, Bahtiar AJIJOAP Formulation and evaluation of quercetin nanoparticle gel for osteoarthritis. Int J Appl Pharm 11 5 — Lee HN et al Anti-inflammatory effect of quercetin and galangin in LPS-stimulated RAW Int J Mol Med 41 2 — Saeedi-Boroujeni A, Mahmoudian-Sani M-RJJOI Anti-inflammatory potential of Quercetin in COVID treatment.
J Inflamm 18 1 :1—9. Ozyel B et al Anti-inflammatory effects of quercetin on high-glucose and pro-inflammatory cytokine challenged vascular endothelial cell metabolism. Mol Nutr Food Res 65 6 Patra M et al Calcium phosphate-quercetin nanocomposite CPQN : A multi-functional nanoparticle having pH indicating, highly fluorescent and anti-oxidant properties.
Coll Surf B Biointerfaces — Hassanien MM, Saad EA, Radwan KHJJOAPS Antidiabetic activity of cobalt—quercetin complex: A new potential candidate for diabetes treatment.
J Appl Pharm Sci 10 12 — PLoS ONE 16 3 :e Mu Y et al pH-sensitive amphiphilic chitosan-quercetin conjugate for intracellular delivery of doxorubicin enhancement. Carbohydr Polym de Oliveira Pedro R et al Self-assembled amphiphilic chitosan nanoparticles for quercetin delivery to breast cancer cells.
Eur J Pharm Biopharm — J Agric Food Chem 66 48 — Rashedi J et al Anti-tumor effect of quercetin loaded chitosan nanoparticles on induced colon cancer in wistar rats. Adv Pharm Bull 9 3 Nan W et al Topical use of quercetin-loaded chitosan nanoparticles against ultraviolet B radiation.
Front Pharmacol Biomed Pharm — Lv L et al Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer.
Oncotarget 7 22 Download references. The authors are very much thankful to the Department of Pharmaceutics, Faculty of pharmacy, Baha-Uddin-Zakariya university Multan for providing research facilities and Higher Education Commission HEC of Pakistan for providing the funding of the project.
Department of Pharmaceutics, Faculty of Pharmacy, Baha-Uddin-Zakariya University, Multan, Pakistan. Hamdard Institute of Pharmaceutical Sciences, Hamdard University, Islamabad Campus, Islamabad, Pakistan. Institute of Chemical Sciences, Baha-Uddin-Zakariya University, Multan, Pakistan.
You can also search for this author in PubMed Google Scholar. Correspondence to Muhammad Hanif. The authors have indicated that they have no other conflicts of interest with regard to the content of this article.
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et al. An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: a review.
Download citation. Received : 16 September Revised : 30 December Accepted : 07 January Published : 30 January Issue Date : January Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.
Download PDF. Abstract Flavonoids are present naturally in many fruits and vegetables including onions, apples, tea, cabbage, cauliflower, berries and nuts which provide us with quercetin, a powerful natural antioxidant and cytotoxic compound.
Flavonoids: A Nutraceutical and Its Role as Anti-inflammatory and Anticancer Agent Chapter © An insight into the potentially old-wonder molecule—quercetin: the perspectives in foresee Article 09 September Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases Article Open access 15 May Use our pre-submission checklist Avoid common mistakes on your manuscript.
Introduction Polyphenolic molecules possess diverse chemical structures and properties. Sources of quercetin Quercetin is found in many fruits, vegetables and in more than twenty species of plants particularly in Mangifera indica, Emblica officinalis, Withania somnifera, Cuscuta reflexa, Santalum album, Curcuma domestica valenton and Foeniculum vulgare.
Sources and uses of quercetin. Full size image. Search strategy A comprehensive data search was conducted between June and July on google scholar, ScienceDirect, PubMed, SpringerLink and Wiley online library to include newly published articles to date.
Eligibility criteria and data collection Articles were considered eligible if they meet the following criteria: a in vivo animal study, b ex vivo cell line studies, c quercetin uses as antioxidant, antidiabetic, anticancer, antimicrobial agents, d quercetin conjugates with chitosan, e complexes of quercetin with metal ions, f use of quercetin in other diseases and g Language is English.
Table 2 Summary of uses of quercetin as antioxidant, antimicrobial, antidiabetic and anticancer agent Full size table.
Cellular mechanism of quercetin as anticancer, antidiabetic, antioxidant and antimicrobial agent. Conclusion This review examined that quercetin is a safe dietary supplement with a variety of biological functions in animals as well as in humans.
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The prevalence Qkercetin fungal infections is growing at an alarming pace and the pathogenesis is Quercetkn not clearly understood. Recurrence of these fungal Quercetin and anti-fungal properties is often due propertise their evolutionary avoidance Multivitamin for prenatal health antifungal resistance. The development of suitable novel antimicrobial agents for fungal diseases continues to be a major problem in the current clinical field. Hence, it is urgently necessary to develop surrogate agents that are more effective than conventional available drugs. Among the remarkable innovations from earlier investigations on natural-drugs, flavonoids are a group of plant-derived substances capable of promoting many valuable effects on humans. Flavonoids are present naturally in many fruits and vegetables Querceyin onions, anti-fnugal, tea, cabbage, cauliflower, Quercetin and anti-fungal properties propedties nuts which provide us with quercetin, Quercetin and anti-fungal properties Qyercetin natural Low Sodium Meals and properteis compound. Due to antioxidant property, many nutraceuticals and cosmeceuticals products Querctein quercetin as a major ingredient nowadays. Literature search was systematically done using scientific for the published articles of quercetin. Literature search also revealed that quercetin alone and its complexes with chitosan, metal ions and polymers possessed good antidiabetic properties. Thus, the review focuses on new therapeutic interventions and drug delivery system of quercetin in medical field for the benefit of mankind. Nidhi Rani, Lakshmi Palanisamy Thanga Velan, … Annamalai Arunachalam. Aar Rafi Mahmud, Tanzila Ismail Ema, … Md.
das Requisit wird erhalten, welche jenes