Longevity and prevention of age-related diseases -
As the simplest example, calorie restriction CR slows aging in diverse organisms, including primates [ 43 — 50 ]. Similarly, intermittent fasting IF and ketogenic diet severe carbohydrate restriction extend life span in mammals [ 48 , 51 — 54 ]. CR as well as carbohydrate restriction and IF fasting improves health in humans [ 45 , 48 , 53 , 55 — 62 ].
However, CR is unpleasant to most humans and its life-extending capacity is limited. Nutrients activate the mTOR molecular Target of Rapamycin nutrient-sensing pathway [ 63 — 65 ] and, as we will discuss mTOR drives aging, inhabitable by rapamycin.
Rapamycin-based anti-aging therapies have been recently implemented by Dr. Alan Green. Rapamycin, everolimus and deforolimus slow geroconversion [ 67 — 75 ]. It has been predicted that rapamycin would slow aging in mammals [ 10 , 76 ]. Starting in , numerous studies have demonstrated that rapamycin prolongs life in mice [ 75 , 77 — 99 ], even when started late in life [ 77 , 78 , 97 — 99 ], or administrated transiently or intermittently [ 77 , 88 , 89 , 95 ].
In these studies, rapamycin was most effective at high doses [ 88 , 89 , 93 — 96 , — ]. Its effect and that of everolimus lingers after their discontinuation [ ], even after a single dose [ ].
What appears to be important is to reach high peak levels using a single high dose [ 93 , 94 ]. In a randomized controlled trial, middle-aged companion dogs administrated rapamycin exhibited no further side effects as compared to dogs receiving the placebo [ ].
Millions of patients with various diseases and conditions e. Rapamycin in a single dose of 15 mg was administrated to healthy volunteers without adverse effects [ ]. In yet another study, comparison to placebo revealed no real everolimus-induced side effects in the elderly [ ].
Moreover, everolimus improves immunity [ ] and reduces infections in elderly healthy humans [ ]. In placebo-controlled studies, side effects of rapamycin and everolimus are manageable with dose reduction and interruption.
Discontinuation due to toxicity was uncommon [ ]. Matt Kaeberlein suggests that conventional doses of rapamycin maybe sub-optimal for maximum life-extension [ ]. I agree with this opinion. Metformin is used not only to treat diabetes but also pre-diabetes in order to prevent diabetes [ 20 — 23 ].
Metformin decreases insulin-resistance and body weight and prevents diabetes, cancer and cardiovascular disease [ 21 , 22 , — ]. It is expected that metformin would extend life and, in fact, metformin does decrease all-cause mortality [ , ].
Physicians generally do not think of metformin as an anti-aging drug, simply because it is expected that life will be extended, if diseases are prevented. In mice, metformin extends healthspan and lifespan [ , — ].
It also extends the lifespan of C. elegans [ — ], which do not suffer from human diseases. Gerontologists think of metformin as an anti-aging drug [ — ], and metformin can be combined with rapamycin [ ].
Angiotensin-converting enzyme ACE inhibitors e. Vasoconstriction, cardiomyocyte hypertrophy, beta- and alpha- adrenergic hyperstimulation all lead to high blood pressure systemic hyperfunction , which, in turn can contribute to stroke, myocardial infarction and renal failure. ACE inhibitors and ARBs decrease vasoconstriction and prevent cardiac hypertrophy.
They are life-extending drugs because they treat deadly diseases. Notably, ACE inhibitors increase the lifespan in rodents with normal blood pressure [ — ], thereby acting as anti-aging drugs.
Combinations of aspirin, statins, beta-blockers and ACE inhibitors are given to aging individuals to prevent cardiovascular diseases [ ]. On the other hand, these drugs extend life span in rodents and Drosophila [ ]. Typical combinations polypill include an antiplatelet agent aspirin , a statin and two blood pressure-lowering drugs such as lisinopril and a beta-blocker [ , ].
Aspirin, statins, ACE inhibitors, beta-blockers and metformin prevent some types of cancer and pre-cancerous polyps [ — , — ]. One could say that drugs prevent diseases by slowing aging. Alternatively, it could be said that prevention of diseases slows aging, which is the sum of all diseases and pre-diseases.
If a drug prevents diseases, it will extend lifespan apparently slowing down aging. If a drug slows down aging it will prevent diseases and extend healthspan [ 17 , ]. the cardiovascular polypill could establish a practice that eventually extends to broader spectrum anti-aging treatments e.
It is commonly argued that aging should be defined as a disease so as to accelerate development of anti-aging therapies. This attitude is self-defeating because it allows us to postpone development of anti-aging therapies until aging is pronounced a disease by regulatory bodies, which will not happen soon.
Aging does not need to be defined as a disease to be treated. Anti-aging drugs such as rapamycin delay age-related diseases. If a drug does not delay progression of at least one age-related disease, it cannot possibly be considered as an anti-aging drug, because it will not extend life-span by definition animals die from age-related diseases.
Rapamycin-based combinations include conventional life-extending drugs, which are used to treat and prevent age-related diseases. The author declares no conflicts of interest.
The author did not participate in Editorial process. Mikhail V. Blagosklonny mikhail. blagosklonny roswellpark. Navigate Home Editorial Board Information For Authors Advance Online Publications Current Issue Archive Scientific Integrity Publication Ethics and Publication Malpractice Statements Contact Special Collections Podcast News Room Interviews with Outstanding Authors.
Theory Article Volume 10, Issue 11 pp — Cite this Article How to cite Blagosklonny MV ,. Abstract Is aging a disease?
Endless debate on aging and disease For decades, one of the most debated questions in gerontology was whether aging is a disease or the norm. Aging is the sum of pre-diseases and diseases Aging is an increase in the probability of death due to age-related diseases, which are late manifestations of aging [ 18 ].
Preventive medicine: a step towards anti-aging medicine Aging is the sum of diseases and pre-diseases. To treat what is treatable The fact that aging is an obligatory part of the life of all organisms is not important. Aging is treatable As the simplest example, calorie restriction CR slows aging in diverse organisms, including primates [ 43 — 50 ].
Conventional drugs as anti-aging drugs Metformin is used not only to treat diabetes but also pre-diabetes in order to prevent diabetes [ 20 — 23 ]. Angiotensin II inhibitors Angiotensin-converting enzyme ACE inhibitors e.
Combinations of conventional drugs Combinations of aspirin, statins, beta-blockers and ACE inhibitors are given to aging individuals to prevent cardiovascular diseases [ ].
Conclusion It is commonly argued that aging should be defined as a disease so as to accelerate development of anti-aging therapies. Download PDF Corresponding Author Mikhail V. Keywords gerossuppresants senolytics longevity lifespan. Computational models in non-coding RNA and human disease.
Int J Mol Sci. Article PubMed Central Google Scholar. Xu P, Wang L, Chen D, Feng M, Lu Y, Chen R, et al. The application of proteomics in the diagnosis and treatment of bronchial asthma.
Ann Transl Med. Yung PYK, Elsässer SJ. Evolution of epigenetic chromatin states. Curr Opin Chem Biol. Hashimoto H, Vertino PM, Cheng X. Molecular coupling of DNA methylation and histone methylation. Morris BJ, Willcox BJ, Donlon TA. Genetic and epigenetic regulation of human aging and longevity.
Molina-Serrano D, Kyriakou D, Kirmizis A. Histone modifications as an intersection between diet and longevity. Front Genet. Huang B, Zhong D, Zhu J, An Y, Gao M, Zhu S, et al. Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines.
Rosa-Garrido M, Chapski DJ, Vondriska TM. Epigenomes in cardiovascular disease. Circ Res. Ibrahim DM, Mundlos S. The role of 3D chromatin domains in gene regulation: a multi-facetted view on genome organization. Curr Opin Genet Dev. Evans SA, Horrell J, Neretti N.
The three-dimensional organization of the genome in cellular senescence and age-associated diseases. Semin Cell Dev Biol.
Bhadra M, Howell P, Dutta S, Heintz C, Mair WB. Alternative splicing in aging and longevity. Hum Genet. Wei L, Sun J, Zhang N, Zheng Y, Wang X, Lv L, et al. Noncoding RNAs in gastric cancer: implications for drug resistance. Mol Cancer. Kinser HE, Pincus Z.
MicroRNAs as modulators of longevity and the aging process. Shi Z, Zhang K, Zhou H, Jiang L, Xie B, Wang R, et al. Basisty N, Meyer JG, Schilling B. Protein turnover in aging and longevity. Article PubMed CAS Google Scholar. Hofmann JW, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, et al.
Reduced expression of MYC increases longevity and enhances healthspan. Su L, Chen S, Zheng C, Wei H, Song X. Front Neurosci. Balashanmugam MV, Shivanandappa TB, Nagarethinam S, Vastrad B, Vastrad C.
Analysis of differentially expressed genes in coronary artery disease by integrated microarray analysis. Article PubMed Central CAS Google Scholar. Wang W, Liu Q, Wang Y, Piao H, Li B, Zhu Z, et al. Integration of gene expression profile data of human Epicardial adipose tissue from coronary artery disease to verification of hub genes and pathways.
Biomed Res Int. Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Barko PC, McMichael MA, Swanson KS, Williams DA.
The gastrointestinal microbiome: a review. J Vet Intern Med. Haran JP, Bhattarai SK, Foley SE, Dutta P, Ward DV, Bucci V, et al. Article Google Scholar.
Kurilshikov A, van den Munckhof ICL, Chen L, Bonder MJ, Schraa K, Rutten JHW, et al. Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk. Huang Y, Rosenberg M, Hou L, Hu M. Relationships among environment, climate, and longevity in China.
Int J Environ Res Public Health. Fontana L, Partridge L. Promoting health and longevity through diet: from model organisms to humans. Yang Y, Zhang L. The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways.
Food Funct. Pallazola VA, Davis DM, Whelton SP, Cardoso R, Latina JM, Michos ED, et al. Mayo Clin Proc Innov Qual Outcomes. Vatner SF, Zhang J, Oydanich M, Berkman T, Naftalovich R, Vatner DE.
Healthful aging mediated by inhibition of oxidative stress. Ageing Res Rev. Zhang H, Davies KJA, Forman HJ. Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med. Reed M, Best J, Golubitsky M, Stewart I, Nijhout HF. Analysis of homeostatic mechanisms in biochemical networks.
Bull Math Biol. Krycer JR, Quek LE, Francis D, Zadoorian A, Weiss FC, Cooke KC, et al. Insulin signaling requires glucose to promote lipid anabolism in adipocytes. J Biol Chem. Han S, Schroeder EA, Silva-García CG, Hebestreit K, Mair WB, Brunet A. Mono-unsaturated fatty acids link H3K4me3 modifiers to C.
elegans lifespan. Wei S, Gao L, Jiang Y, Shang S, Chen C, Dang L, et al. The Apolipoprotein E ε4 allele-dependent relationship between serum lipid levels and cognitive function: a population-based cross-sectional study. Front Aging Neurosci. Wegner CJ, Kim B, Lee J. Trust your gut: galvanizing nutritional interest in intestinal cholesterol metabolism for protection against cardiovascular diseases.
Campagna J, Spilman P, Jagodzinska B, Bai D, Hatami A, Zhu C, et al. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.
Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases.
Trends Pharmacol Sci. Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, et al. APOE alleles and extreme human longevity. Sun L, Hu C, Zheng C, Huang Z, Lv Z, Huang J, et al. Gene-gene interaction between CETP and APOE polymorphisms confers higher risk for hypertriglyceridemia in oldest-old Chinese women.
Exp Gerontol. Lai RW, Lu R, Danthi PS, Bravo JI, Goumba A, Sampathkumar NK, et al. Multi-level remodeling of transcriptional landscapes in aging and longevity. BMB Rep. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G.
The hallmarks of aging. Download references. This work is supported by grants from by the Natural Science Foundation of China , , , , , , , , ; National Key Research and Development Program of China YFC ; Guangxi Natural Science Foundation GXNSFDA, GXNSFAA, guike ; Self-funded Scientific Research Project of the health and family planning commission of Guangxi Zhuang Autonomous Region Z ; Beijing Hospital Nova Project BJ ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences RC The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, , P.
Graduate School of Chinese Academy of Medical Science and Peking Union Medical College, Beijing, , P. Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, P. You can also search for this author in PubMed Google Scholar.
designed review; XL. collected their information and papers; XL. conducted review and wrote manuscript; HP. had primary responsibility for final content. Correspondence to Ze Yang. This review including researches of us were carried out in accordance with the Declaration of Helsinki of the World Medical Association and received ethical approval from the Ethics Committee of Beijing Hospital, Ministry of Health, China.
The authors declare no competing financial interests relevant to this article. All financial and material support for this research has no potential conflicts. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Open Access This article is licensed under a Creative Commons Attribution 4. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.
If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and permissions.
Ni, X. et al. A description of the relationship in healthy longevity and aging-related disease: from gene to protein. Immun Ageing 18 , 30 Download citation. Received : 01 February Accepted : 14 June Published : 25 June Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Abstract Human longevity is a complex phenotype influenced by both genetic and environmental factors.
Backgroud Since time immemorial, humans have desired longevity, as evidenced by inscriptions found in ancient Egypt and even in older Sumerian tablets [ 1 ].
The process of longevity and aging-related diseases formation. Full size image. Gene variation Based on the conventional genotype-to-phenotype theory, the phenotype trait is determined based on the synchronized interaction between encoded protein shape and genetic expression.
The level of gene expression A useful approach for the identification of molecular markers of aging involves the analysis of changes in gene expression in the elderly.
Regulation of gene expression The central dogma of molecular biology describes the conversion of DNA to RNA to protein [ 30 ]. The level of protein expression Proteostasis involves the maintenance of a functional equilibrium between protein synthesis, fidelity, folding, localization, modification, and degradation and plays an important role in health and longevity.
Importance of genetic and environmental factors Longevity depends on complex interactions between various genetic and environmental factors. Protein networks regulate homeostasis to influence lifespan No matter mutated genes, abnormal regulation of gene expression, or environmental factors, which affected the quality and quantity of protein productions, all impacted homeostasis of cells.
Conclusions Recent studies have enhanced our understanding of the determinants of human lifespan and longevity. References Labat-Robert J, Robert L. Article CAS Google Scholar Zeng Y, Nie C, Min J, Liu X, Li M, Chen H, et al.
Article CAS PubMed PubMed Central Google Scholar Franceschi C, Garagnani P, Olivieri F, Salvioli S, Giuliani C. Article CAS PubMed Google Scholar Gunn-Moore D, Kaidanovich-Beilin O, Gallego Iradi MC, Gunn-Moore F, Lovestone S.
Article PubMed Google Scholar de Jong L, Bobeldijk-Pastorova I, Erdmann J, Bijker-Schreurs M, Schunkert H, Kuivenhoven JA, et al. Article PubMed Google Scholar Chen XF, Chen X, Tang X.
Article CAS Google Scholar Elagizi A, Kachur S, Lavie CJ, Carbone S, Pandey A, Ortega FB, et al. Article PubMed Google Scholar Alzheimer's disease facts and figures. Article CAS Google Scholar Nussinov R, Tsai CJ, Jang H. Article CAS PubMed PubMed Central Google Scholar Schächter F, Faure-Delanef L, Guénot F, Rouger H, Froguel P, Lesueur-Ginot L, et al.
Article PubMed Google Scholar Santos-Lozano A, Santamarina A, Pareja-Galeano H, Sanchis-Gomar F, Fiuza-Luces C, Cristi-Montero C, et al. Article PubMed Google Scholar Dato S, Rose G, Crocco P, Monti D, Garagnani P, Franceschi C, et al.
Article CAS PubMed Google Scholar Belloy ME, Napolioni V, Han SS, Le Guen Y, Greicius MD. Article PubMed PubMed Central Google Scholar Sun L, Hu C, Zheng C, Qian Y, Liang Q, Lv Z, et al.
Article PubMed PubMed Central CAS Google Scholar Sun L, Hu CY, Shi XH, Zheng CG, Huang ZZ, Lv ZP, et al. Article CAS PubMed PubMed Central Google Scholar Huang J, Sun L, Liu M, Zhou L, Lv ZP, Hu CY, et al. CAS PubMed Google Scholar Fortney K, Dobriban E, Garagnani P, Pirazzini C, Monti D, Mari D, et al.
Article PubMed PubMed Central CAS Google Scholar Sanese P, Forte G, Disciglio V, Grossi V, Simone C. Article CAS PubMed PubMed Central Google Scholar Willcox BJ, Morris BJ, Tranah GJ, Chen R, Masaki KH, He Q, et al.
CAS PubMed Google Scholar Zeng CY, Yang TT, Zhou HJ, Zhao Y, Kuang X, Duan W, et al. Article CAS PubMed Google Scholar Zahn JM, Sonu R, Vogel H, Crane E, Mazan-Mamczarz K, Rabkin R, et al.
Article PubMed PubMed Central CAS Google Scholar Passtoors WM, Boer JM, Goeman JJ, Akker EB, Deelen J, Zwaan BJ, et al.
Article CAS PubMed PubMed Central Google Scholar Fushan AA, Turanov AA, Lee SG, Kim EB, Lobanov AV, Yim SH, et al. Article CAS PubMed PubMed Central Google Scholar Honda Y, Tanaka M, Honda S. Article PubMed Google Scholar Freude S, Schilbach K, Schubert M.
Article CAS PubMed Google Scholar Khan AH, Zou Z, Xiang Y, Chen S, Tian XL. Article CAS PubMed Google Scholar Erlandsson MC, Lyngfelt L, Åberg ND, Wasén C, Espino RA, Silfverswärd ST, et al. Article PubMed PubMed Central CAS Google Scholar Maximus PS.
Article PubMed Google Scholar Schneider-Poetsch T, Yoshida M. Article CAS PubMed Google Scholar Chen X, Wang CC, Guan NN. Article PubMed Central Google Scholar Xu P, Wang L, Chen D, Feng M, Lu Y, Chen R, et al. Article CAS PubMed PubMed Central Google Scholar Yung PYK, Elsässer SJ. Article CAS PubMed Google Scholar Hashimoto H, Vertino PM, Cheng X.
Article CAS PubMed Google Scholar Morris BJ, Willcox BJ, Donlon TA. Article CAS PubMed Google Scholar Molina-Serrano D, Kyriakou D, Kirmizis A.
Article CAS PubMed PubMed Central Google Scholar Huang B, Zhong D, Zhu J, An Y, Gao M, Zhu S, et al. Article CAS PubMed PubMed Central Google Scholar Rosa-Garrido M, Chapski DJ, Vondriska TM. Article CAS PubMed PubMed Central Google Scholar Ibrahim DM, Mundlos S.
Article CAS PubMed Google Scholar Evans SA, Horrell J, Neretti N. Article CAS PubMed Google Scholar Bhadra M, Howell P, Dutta S, Heintz C, Mair WB. Article PubMed Google Scholar Wei L, Sun J, Zhang N, Zheng Y, Wang X, Lv L, et al.
Article PubMed PubMed Central Google Scholar Kinser HE, Pincus Z. Article CAS PubMed Google Scholar Shi Z, Zhang K, Zhou H, Jiang L, Xie B, Wang R, et al. Article CAS PubMed PubMed Central Google Scholar Basisty N, Meyer JG, Schilling B. Article PubMed CAS Google Scholar Hofmann JW, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, et al.
Article CAS PubMed PubMed Central Google Scholar Su L, Chen S, Zheng C, Wei H, Song X. Article PubMed PubMed Central Google Scholar Balashanmugam MV, Shivanandappa TB, Nagarethinam S, Vastrad B, Vastrad C.
Article PubMed Central CAS Google Scholar Wang W, Liu Q, Wang Y, Piao H, Li B, Zhu Z, et al. Article PubMed PubMed Central Google Scholar Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, et al.
Article CAS PubMed PubMed Central Google Scholar Barko PC, McMichael MA, Swanson KS, Williams DA. Article CAS PubMed Google Scholar Haran JP, Bhattarai SK, Foley SE, Dutta P, Ward DV, Bucci V, et al. Article Google Scholar Kurilshikov A, van den Munckhof ICL, Chen L, Bonder MJ, Schraa K, Rutten JHW, et al.
Article CAS PubMed Google Scholar Huang Y, Rosenberg M, Hou L, Hu M. Article Google Scholar Fontana L, Partridge L. Article CAS PubMed PubMed Central Google Scholar Yang Y, Zhang L.
Article PubMed Google Scholar Pallazola VA, Davis DM, Whelton SP, Cardoso R, Latina JM, Michos ED, et al. Article PubMed PubMed Central Google Scholar Vatner SF, Zhang J, Oydanich M, Berkman T, Naftalovich R, Vatner DE. Article CAS PubMed PubMed Central Google Scholar Zhang H, Davies KJA, Forman HJ.
Article CAS PubMed PubMed Central Google Scholar Reed M, Best J, Golubitsky M, Stewart I, Nijhout HF. Article CAS PubMed PubMed Central Google Scholar Krycer JR, Quek LE, Francis D, Zadoorian A, Weiss FC, Cooke KC, et al.
Article CAS PubMed PubMed Central Google Scholar Han S, Schroeder EA, Silva-García CG, Hebestreit K, Mair WB, Brunet A. Article CAS PubMed PubMed Central Google Scholar Wei S, Gao L, Jiang Y, Shang S, Chen C, Dang L, et al. Article CAS PubMed PubMed Central Google Scholar Wegner CJ, Kim B, Lee J.
Article CAS PubMed PubMed Central Google Scholar Campagna J, Spilman P, Jagodzinska B, Bai D, Hatami A, Zhu C, et al.
Article PubMed PubMed Central CAS Google Scholar Hubbard BP, Sinclair DA. Article CAS PubMed PubMed Central Google Scholar Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, et al. Article CAS PubMed Google Scholar Sun L, Hu C, Zheng C, Huang Z, Lv Z, Huang J, et al.
Article CAS PubMed Google Scholar Lai RW, Lu R, Danthi PS, Bravo JI, Goumba A, Sampathkumar NK, et al. Article CAS PubMed PubMed Central Google Scholar López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Article PubMed PubMed Central CAS Google Scholar Download references. Acknowledgements We thank all participants involved in these reviews.
Funding This work is supported by grants from by the Natural Science Foundation of China , , , , , , , , ; National Key Research and Development Program of China YFC ; Guangxi Natural Science Foundation GXNSFDA, GXNSFAA, guike ; Self-funded Scientific Research Project of the health and family planning commission of Guangxi Zhuang Autonomous Region Z ; Beijing Hospital Nova Project BJ ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences RC Author information Authors and Affiliations The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, , P.
Return to the tutorial menu. Longevity has djseases Longevity and prevention of age-related diseases during human history, with periods of prevebtion during periods of war, famine, and disease, most recently due to the worldwide coronavirus pandemic. Inlongevity ranged from 53 years for the Central African Republic to In general, women outlive men. html accessed May 5,Longevity and prevention of age-related diseases -
You can also search for this author in PubMed Google Scholar. Compiles research on antioxidants and their biological mechanisms that mediate age-related diseases.
This is a preview of subscription content, log in via an institution to check for access. The average life expectancy has increased worldwide in the recent decades. Studies and research have shown the potential preventive and therapeutic roles of antioxidants in aging and age-related diseases by inhibiting the formation or disrupting the propagation of free radicals and thus increasing healthy longevity, enhancing immune function, and decreasing oxidative stress.
This has made an antioxidant rich diet of increasing importance in battling the detrimental effects of the aging process. This book covers the major issues linked to antioxidants, aging, and age-related diseases, including changes in organ systems over the lifespan, age-related oxidative stress-induced redox imbalance, inflammaging, implications of inflammation in aging and age-related diseases, and the important role of antioxidant-rich foods in their prevention and treatment of various age-related diseases.
Bee Ling Tan, Mohd Esa Norhaizan. Bee Ling Tan is a researcher in the Department of Nutrition, Faculty of Medicine and Health Sciences at the Universiti Putra Malaysia in Serdang, Selangor, Malaysia. Mohd Esa Norhaizan is an Associate Professor in the Department of Nutrition, Faculty of Medicine and Health Sciences at the Universiti Putra Malaysia in Serdang, Selangor, Malaysia.
Book Title : The Role of Antioxidants in Longevity and Age-Related Diseases. Authors : Bee Ling Tan, Mohd Esa Norhaizan. Publisher : Springer Cham. eBook Packages : Biomedical and Life Sciences , Biomedical and Life Sciences R0. Copyright Information : The Editor s if applicable and The Author s , under exclusive license to Springer Nature Switzerland AG Hardcover ISBN : Published: 20 November Softcover ISBN : Published: 21 November eBook ISBN : Published: 19 November Edition Number : 1.
Nogueira LM, Dunlap SM, Ford NA, Hursting SD. Calorie restriction and rapamycin inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity.
Endocr Relat Cancer. Lashinger LM, Malone LM, Brown GW, Daniels EA, Goldberg JA, Otto G, et al. Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer. Hussein O, Tiedemann K, Murshed M, Komarova SV. Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases.
Cancer Lett. Chiong E, Lee IL, Dadbin A, Sabichi AL, Harris L, Urbauer D, et al. Effects of mTOR inhibitor everolimus RAD on bladder cancer cells. Clin Cancer Res. Hoda MA, Mohamed A, Ghanim B, Filipits M, Hegedus B, Tamura M, et al.
Temsirolimus inhibits malignant pleural mesothelioma growth in vitro and in vivo: synergism with chemotherapy. J Thorac Oncol. Ohara T, Takaoka M, Toyooka S, Tomono Y, Nishikawa T, Shirakawa Y, et al. Inhibition of mTOR by temsirolimus contributes to prolonged survival of mice with pleural dissemination of non-small-cell lung cancer cells.
Cancer Sci. Shioi T, McMullen JR, Tarnavski O, Converso K, Sherwood MC, Manning WJ, et al. Rapamycin attenuates load-induced cardiac hypertrophy in mice.
McMullen JR, Sherwood MC, Tarnavski O, Zhang L, Dorfman AL, Shioi T, et al. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Boluyt MO, Li ZB, Loyd AM, Scalia AF, Cirrincione GM, Jackson RR.
Cardiovasc Drugs Ther. Ha T, Li Y, Hua F, Ma J, Gao X, Kelley J, et al. Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res. Gao X-M, Wong G, Wang B, Kiriazis H, Moore X-L, Su Y-D, et al.
Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis. J Hypertens. Marin TM, Keith K, Davies B, Conner DA, Guha P, Kalaitzidis D, et al. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome—associated PTPN11 mutation.
Chen X, Zeng S, Zou J, Chen Y, Yue Z, Gao Y, et al. Rapamycin attenuated cardiac hypertrophy induced by isoproterenol and maintained energy homeostasis via inhibiting NF-κB activation.
Mediat Inflamm. Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, et al. Am J Physiol Heart Circ Physiol. Zhang W, He H, Song H, Zhao J, Li T, Wu L, et al.
J Parkinsons Dis. Masini D, Bonito-Oliva A, Bertho M, Fisone G. Front Neurol. Puighermanal E, Marsicano G, Busquets-Garcia A, Lutz B, Maldonado R, Ozaita A. Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling.
Nat Neurosci. Wang X, Seekaew P, Gao X, Chen J. Traumatic brain injury stimulates neural stem cell proliferation via mammalian target of rapamycin signaling pathway activation.
Shen W, Lu K, Wang J, Wu A, Yue Y. Activation of mTOR signaling leads to orthopedic surgery-induced cognitive decline in mice through β-amyloid accumulation and tau phosphorylation. Mol Med Rep. Liu W, Guo JN, Mu J, Tian L, Zhou D. Rapamycin protects sepsis-induced cognitive impairment in mouse hippocampus by enhancing autophagy.
Cell Mol Neurobiol. Yuan H, Wu G, Zhai X, Lu B, Meng B, Chen J. Melatonin and rapamycin attenuate isoflurane-induced cognitive impairment through inhibition of neuroinflammation by suppressing the mTOR signaling in the hippocampus of aged mice.
Front Aging Neurosci. Zhou M, Li W, Huang S, Song J, Kim Ju Y, Tian X, et al. mTOR inhibition ameliorates cognitive and affective deficits caused by disc1 knockdown in adult-born dentate granule neurons. Brewster AL, Lugo JN, Patil VV, Lee WL, Qian Y, Vanegas F, et al.
Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. Lorne E, Zhao X, Zmijewski JW, Liu G, Park Y-J, Tsuruta Y, et al.
Participation of mammalian target of rapamycin complex 1 in toll-like receptor 2—and 4—induced neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol. Li Z, Chen L, Sun Y, Li G. Neurosci Lett. Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, et al.
Fielhaber JA, Carroll SF, Dydensborg AB, Shourian M, Triantafillopoulos A, Harel S, et al. Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis.
Goldberg EL, Romero-Aleshire MJ, Renkema KR, Ventevogel MS, Chew WM, Uhrlaub JL, et al. Lifespan-extending caloric restriction or m TOR inhibition impair adaptive immunity of old mice by distinct mechanisms.
Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV, Blagosklonny MV. Rapamycin decelerates cellular senescence. Zhuo L, Cai G, Liu F, Fu B, Liu W, Hong Q, et al. Expression and mechanism of mammalian target of rapamycin in age-related renal cell senescence and organ aging.
Mech Ageing Dev. Leontieva OV, Demidenko ZN, Gudkov AV, Blagosklonny MV. Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin.
Zhang S, Cai G, Fu B, Feng Z, Ding R, Bai X, et al. SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence.
Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo AA, Mitchell JB, et al. mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.
Pospelova TV, Leontieva OV, Bykova TV, Zubova SG, Pospelov VA, Blagosklonny MV. Suppression of replicative senescence by rapamycin in rodent embryonic cells. Lerner C, Bitto A, Pulliam D, Nacarelli T, Konigsberg M, Van Remmen H, et al. Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts.
Panganiban RA, Day RM. Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence. Wang R, Yu Z, Sunchu B, Shoaf J, Dang I, Zhao S, et al.
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism. Kawakami Y, Hambright WS, Takayama K, Mu X, Lu A, Cummins JH, et al. Mol Ther Methods Clin Dev. Download references. The efforts of authors were financially supported by NIH grants R01AG, R01AG, and a Senior Career Research Award AR and a Merit grant I01BX from the Department of Veterans Affairs.
Oklahoma City VA Medical Center, Oklahoma City, OK, USA. You can also search for this author in PubMed Google Scholar. Correspondence to Arlan Richardson. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This article is published under an open access license.
Please check the 'Copyright Information' section either on this page or in the PDF for details of this license and what re-use is permitted. If your intended use exceeds what is permitted by the license or if you are unable to locate the licence and re-use information, please contact the Rights and Permissions team.
Selvarani, R. Effect of rapamycin on aging and age-related diseases—past and future. GeroScience 43 , — Download citation. Received : 20 July Accepted : 21 September Published : 10 October Issue Date : June Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.
Download PDF. Abstract In , rapamycin was reported to increase the lifespan of mice when implemented later in life. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging Article Open access 19 August Dopamine: Functions, Signaling, and Association with Neurological Diseases Article 16 November Use our pre-submission checklist Avoid common mistakes on your manuscript.
Introduction Rapamycin also known by the trade names of sirolimus or rapamune is a macrocyclic lactone produced by Streptomyces hygroscopicus , which was isolated from soil samples collected from Easter Island by Georges Nogrady in the late s [ 1 ].
Effect of rapamycin on the lifespan of mice The first data suggesting that rapamycin might affect longevity came from studies with invertebrates. Table 1 Effect of rapamycin on lifespan of various strains of mice Full size table. Table 2 Effect of rapamycin on lifespan of various mouse models of human disease Full size table.
Effect of rapamycin on cancer in mouse models Rapamycin would be predicted to reduce the progression of cancer because it has been shown to inhibit cell growth and proliferation. Table 3 Ability of mTOR inhibitors to reduce cancer Full size table. Effect of rapamycin on cardiac function and disease in mice The first indication that rapamycin might be important for the heart was the discovery that coronary stents coated with rapamycin prevented restenosis and stent thrombosis compared with non-coated or other drug-eluting stents [ 45 ], which led to FDA approval in Table 4 Effect of rapamycin on heart disease and function in rodents Full size table.
Table 5 Effect of rapamycin on the central nervous system of mice Full size table. Effect of rapamycin on the immune response to infectious agents in mice Because rapamycin was first developed as part of a cocktail to prevent rejection in transplant patients, it is generally assumed that rapamycin is an immunosuppressant.
Effect of rapamycin on cell senescence In , Leonard Hayflick described the phenomenon of cell senescence when he showed that human fibroblasts did not grow indefinitely in culture but underwent irreversible growth arrest [ ].
Table 7 Effect of rapamycin on cell senescence Full size table. Summary In the 10 years since the initial report that rapamycin increased the lifespan of mice, there has been an explosion in the number of reports studying the effect of rapamycin on various parameters related to aging in mice.
Conclusion—where do we go from here? CAS PubMed Google Scholar Brown EJ, Albers MW, Bum Shin T, ichikawa K, Keith CT, Lane WS et al. Article CAS PubMed Google Scholar Chiu MI, Katz H, Berlin V. CAS PubMed PubMed Central Google Scholar Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al.
Article CAS PubMed PubMed Central Google Scholar Johnson SC, Rabinovitch PS, Kaeberlein M. Article CAS PubMed PubMed Central Google Scholar Ehninger D, Neff F, Xie K. Article CAS PubMed PubMed Central Google Scholar Richardson A, Galvan V, Lin AL, Oddo S. Article CAS PubMed Google Scholar Arriola Apelo SI, Lamming DW.
Article CAS PubMed PubMed Central Google Scholar Swindell WR. Article Google Scholar Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Müller F. Article CAS PubMed Google Scholar Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, et al. Article CAS PubMed Google Scholar Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S.
Article CAS PubMed PubMed Central Google Scholar Powers RW, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. CAS PubMed PubMed Central Google Scholar Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, et al. Article CAS PubMed PubMed Central Google Scholar Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, et al.
Article CAS PubMed Google Scholar Nadon NL, Strong R, Miller RA, Harrison DE. Article PubMed Google Scholar Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, et al.
Article CAS PubMed PubMed Central Google Scholar Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, et al.
Article CAS Google Scholar Khapre RV, Kondratova AA, Patel S, Dubrovsky Y, Wrobel M, Antoch MP, et al. Article CAS Google Scholar Siegmund SE, Yang H, Sharma R, Javors M, Skinner O, Mootha V, et al. Article CAS PubMed PubMed Central Google Scholar Johnson SC, Yanos M, Sangesland M, Bitto A, Castanza A, Gagnidze A, et al.
PubMed PubMed Central Google Scholar Reifsnyder PC, Ryzhov S, Flurkey K, Anunciado-Koza RP, Mills I, Harrison DE, et al. Article CAS PubMed PubMed Central Google Scholar Zhang X, Li L, Chen S, Yang D, Wang Y, Zhang X, et al. Article CAS PubMed Google Scholar Bhattacharya B, Akram M, Balasubramanian I, Tam KK, Koh KX, Yee MQ, et al.
Article CAS PubMed Google Scholar Sataranatarajan K, Ikeno Y, Bokov A, Feliers D, Yalamanchili H, Lee HJ, et al. Article CAS PubMed Google Scholar Ferrara-Romeo I, Martinez P, Saraswati S, Whittemore K, Graña-Castro O, Thelma Poluha L, et al.
Article CAS PubMed PubMed Central Google Scholar Fang Y, Hill CM, Darcy J, Reyes-Ordoñez A, Arauz E, McFadden S, et al. Article CAS PubMed PubMed Central Google Scholar Shor B, Gibbons JJ, Abraham RT, Yu K.
Article CAS PubMed Google Scholar Rivera VM, Squillace RM, Miller D, Berk L, Wardwell SD, Ning Y, et al.
Article CAS PubMed Google Scholar Fujishita T, Aoki K, Lane HA, Aoki M, Taketo MM. Article PubMed PubMed Central Google Scholar Koehl GE, Spitzner M, Ousingsawat J, Schreiber R, Geissler EK, Kunzelmann K.
Article CAS PubMed Google Scholar Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, et al. Article CAS Google Scholar Muller PA, Vousden KH. Article CAS PubMed Google Scholar Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV, et al.
Article CAS Google Scholar Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, et al. Article PubMed PubMed Central Google Scholar Comas M, Toshkov I, Kuropatwinski KK, Chernova OB, Polinsky A, Blagosklonny MV, et al.
Article CAS Google Scholar Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, et al. Article CAS PubMed PubMed Central Google Scholar Popovich IG, Anisimov VN, Zabezhinski MA, Semenchenko AV, Tyndyk ML, Yurova MN, et al.
Article CAS PubMed PubMed Central Google Scholar Hernando E, Charytonowicz E, Dudas ME, Menendez S, Matushansky I, Mills J, et al. Article CAS PubMed Google Scholar Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, et al. Article CAS Google Scholar Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, et al.
Article CAS PubMed PubMed Central Google Scholar Abizaid A. Article CAS PubMed PubMed Central Google Scholar Park H-J, Kim H-Y, Lee J-M, Choi YS, Park C-S, Kim D-B, et al.
Article CAS PubMed Google Scholar Morrisett JD, Abdel-Fattah G, Hoogeveen R, Mitchell E, Ballantyne CM, Pownall HJ, et al. CAS PubMed Google Scholar Fuke S, Maekawa K, Kawamoto K, Saito H, Sato T, Hioka T, et al. Article CAS PubMed Google Scholar Jabs A, Göbel S, Wenzel P, Kleschyov AL, Hortmann M, Oelze M, et al.
Article CAS PubMed Google Scholar Jahrling JB, Lin A-L, DeRosa N, Hussong SA, Van Skike CE, Girotti M, et al. Article CAS PubMed Google Scholar Pakala R, Stabile E, Jang GJ, Clavijo L, Waksman R. Article CAS PubMed Google Scholar Zhao L, Ding T, Cyrus T, Cheng Y, Tian H, Ma M, et al.
Article CAS PubMed PubMed Central Google Scholar Mueller MA, Beutner F, Teupser D, Ceglarek U, Thiery J. Article CAS PubMed Google Scholar Ross C, Salmon A, Strong R, Fernandez E, Javors M, Richardson A, et al.
Article CAS Google Scholar Buss SJ, Muenz S, Riffel JH, Malekar P, Hagenmueller M, Weiss CS, et al. Article CAS PubMed Google Scholar Di R, Wu X, Chang Z, Zhao X, Feng Q, Lu S, et al. Article CAS PubMed Google Scholar Dai DF, Karunadharma PP, Chiao YA, Basisty N, Crispin D, Hsieh EJ, et al.
Article CAS PubMed PubMed Central Google Scholar Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DEL, et al. Article CAS PubMed PubMed Central Google Scholar Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, Costa-Mattioli M.
Article PubMed PubMed Central Google Scholar Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Article CAS PubMed PubMed Central Google Scholar Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D.
Article CAS PubMed Google Scholar Majumder S, Richardson A, Strong R, Oddo S. Article CAS PubMed PubMed Central Google Scholar Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, et al. Article CAS PubMed PubMed Central Google Scholar Siman R, Cocca R, Dong Y.
Article CAS PubMed PubMed Central Google Scholar Lin A-L, Jahrling JB, Zhang W, DeRosa N, Bakshi V, Romero P, et al. CAS PubMed Google Scholar Tramutola A, Lanzillotta C, Barone E, Arena A, Zuliani I, Mosca L et al.
Article CAS PubMed PubMed Central Google Scholar Zhu F, Fan M, Xu Z, Cai Y, Chen Y, Yu S, et al. PubMed Google Scholar Bai X, Wey MC-Y, Fernandez E, Hart MJ, Gelfond J, Bokov AF, et al.
Article CAS PubMed Google Scholar Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, et al. Article CAS PubMed Google Scholar Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, et al.
Article CAS PubMed Google Scholar King MA, Hands S, Hafiz F, Mizushima N, Tolkovsky AM, Wyttenbach A. Article CAS PubMed Google Scholar Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, et al.
Article CAS PubMed Google Scholar Majumder S, Caccamo A, Medina DX, Benavides AD, Javors MA, Kraig E, et al. Article CAS PubMed Google Scholar Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, et al.
Article CAS PubMed PubMed Central Google Scholar Van Skike CE, Lin A-L, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J et al. Article CAS PubMed PubMed Central Google Scholar Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM, et al.
Article CAS PubMed PubMed Central Google Scholar Cambiaghi M, Cursi M, Magri L, Castoldi V, Comi G, Minicucci F, et al. Article CAS PubMed Google Scholar Cox RL, Calderon de Anda F, Mangoubi T, Yoshii A. Article CAS PubMed Google Scholar Hadamitzky M, Herring A, Kirchhof J, Bendix I, Haight MJ, Keyvani K, et al.
Article CAS PubMed PubMed Central Google Scholar Blagosklonny MV. Article CAS Google Scholar Weichhart T, Hengstschläger M, Linke M. Article CAS PubMed PubMed Central Google Scholar Jones RG, Pearce EJ. CAS PubMed PubMed Central Google Scholar Snyder JP, Amiel E.
PubMed PubMed Central Google Scholar Nouwen LV, Everts B. CAS PubMed Central Google Scholar Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM, et al. CAS PubMed Google Scholar Jagannath C, Lindsey DR, Dhandayuthapani S, Xu Y, Hunter RL Jr, Eissa NT.
CAS PubMed Google Scholar Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, et al. CAS PubMed PubMed Central Google Scholar Keating R, Hertz T, Wehenkel M, Harris TL, Edwards BA, McClaren JL, et al.
CAS PubMed PubMed Central Google Scholar Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, et al.
PubMed Google Scholar Mannick JB, Morris M, Hockey H-UP, Roma G, Beibel M, Kulmatycki K, et al. PubMed Google Scholar Goldberg EL, Smithey MJ, Lutes LK, Uhrlaub JL, Nikolich-Žugich J. CAS PubMed Google Scholar Ferrer IR, Wagener ME, Robertson JM, Turner AP, Araki K, Ahmed R, et al.
CAS PubMed Google Scholar Hayflick L, Moorhead PS. CAS PubMed Google Scholar Shay JW, Wright WE. Article CAS PubMed Google Scholar Coppé J-P, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, et al.
Article CAS PubMed Google Scholar Tchkonia T, Zhu Y, Van Deursen J, Campisi J, Kirkland JL. CAS PubMed PubMed Central Google Scholar Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, et al. Article CAS PubMed Google Scholar Laberge R-M, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, et al.
CAS PubMed PubMed Central Google Scholar Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, et al. CAS PubMed PubMed Central Google Scholar Houssaini A, Breau M, Kanny Kebe SA, Marcos E, Lipskaia L, Rideau D et al. Article Google Scholar Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS.
Article CAS PubMed PubMed Central Google Scholar Hinojosa CA, Mgbemena V, Van Roekel S, Austad SN, Miller RA, Bose S, et al. CAS PubMed PubMed Central Google Scholar Lesniewski LA, Seals DR, Walker AE, Henson GD, Blimline MW, Trott DW, et al.
Article CAS PubMed Google Scholar Chung CL, Lawrence I, Hoffman M, Elgindi D, Nadhan K, Potnis M, et al. Article CAS PubMed PubMed Central Google Scholar Quarles E, Basisty N, Chiao YA, Merrihew G, Gu H, Sweetwyne MT, et al. Article CAS PubMed Google Scholar Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB.
Article CAS PubMed Google Scholar Kaeberlein M, Galvan V. Article CAS PubMed PubMed Central Google Scholar Brattström C, Säwe J, Jansson B, Lönnebo A, Nordin J, Zimmerman JJ, et al.
PubMed Google Scholar Soefje SA, Karnad A, Brenner AJ. Article PubMed Google Scholar Cohen EEW. Article PubMed Google Scholar Ceschi A, Heistermann E, Gros S, Reichert C, Kupferschmidt H, Banner NR, et al. Article CAS PubMed PubMed Central Google Scholar Mita M, Mita A.
Article PubMed Google Scholar Kraig E, Linehan LA, Liang H, Romo TQ, Liu Q, Wu Y, et al. Article CAS PubMed PubMed Central Google Scholar Pavlakis M, Goldfarb-Rumyantzev AS. Article CAS PubMed Central Google Scholar Vemulapalli S, Mita A, Alvarado Y, Sankhala K, Mita M.
PubMed Google Scholar Kaplan B, Qazi Y, Wellen JR. Google Scholar Vina J, Lloret A. PubMed Google Scholar Lin A-L, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, et al. Article CAS PubMed PubMed Central Google Scholar Jiang T, Tan L, Zhu X-C, Zhang Q-Q, Cao L, Tan M-S, et al. CAS PubMed PubMed Central Google Scholar Moreno-Gonzalez I, Estrada LD, Sanchez-Mejias E, Soto C.
Google Scholar Carosi JM, Sargeant TJ. CAS PubMed PubMed Central Google Scholar Bielas J, Herbst A, Widjaja K, Hui J, Aiken JM, McKenzie D, et al.
Article CAS PubMed PubMed Central Google Scholar Kloskowska E, Pham TM, Nilsson T, Zhu S, Oberg J, Codita A, et al. Article CAS PubMed Google Scholar Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, et al.
Article CAS PubMed PubMed Central Google Scholar Carter CS, Richardson A, Huffman DM, Austad S. Article PubMed PubMed Central Google Scholar Hanes J, Zilka N, Bartkova M, Caletkova M, Dobrota D, Novak M. Article CAS PubMed Google Scholar Geula C, Nagykery N, Wu C-K.
CAS PubMed Google Scholar Mansfield K. CAS PubMed Google Scholar Chen C, Liu Y, Liu Y, Zheng P. Article PubMed PubMed Central Google Scholar Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, et al. Article CAS PubMed Google Scholar Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, et al.
Article CAS PubMed PubMed Central Google Scholar Hansel DE, Platt E, Orloff M, Harwalker J, Sethu S, Hicks JL, et al. Article CAS PubMed PubMed Central Google Scholar Stelzer MK, Pitot HC, Liem A, Lee D, Kennedy GD, Lambert PF.
Article CAS Google Scholar Voskamp P, Bodmann CA, Rebel HG, Koehl GE, Tensen CP, Bouwes Bavinck JN, et al. Article CAS PubMed Google Scholar Nogueira LM, Dunlap SM, Ford NA, Hursting SD. Article CAS PubMed Google Scholar Lashinger LM, Malone LM, Brown GW, Daniels EA, Goldberg JA, Otto G, et al.
Article CAS Google Scholar Hussein O, Tiedemann K, Murshed M, Komarova SV. Article CAS PubMed Google Scholar Chiong E, Lee IL, Dadbin A, Sabichi AL, Harris L, Urbauer D, et al.
Article CAS PubMed PubMed Central Google Scholar Hoda MA, Mohamed A, Ghanim B, Filipits M, Hegedus B, Tamura M, et al. Article PubMed Google Scholar Ohara T, Takaoka M, Toyooka S, Tomono Y, Nishikawa T, Shirakawa Y, et al. CAS PubMed Google Scholar Mueller MA, Beutner F, Teupser D, Ceglarek U, Thiery J.
CAS PubMed Google Scholar Shioi T, McMullen JR, Tarnavski O, Converso K, Sherwood MC, Manning WJ, et al. Article CAS PubMed Google Scholar McMullen JR, Sherwood MC, Tarnavski O, Zhang L, Dorfman AL, Shioi T, et al. CAS PubMed Google Scholar Boluyt MO, Li ZB, Loyd AM, Scalia AF, Cirrincione GM, Jackson RR.
CAS PubMed Google Scholar Ha T, Li Y, Hua F, Ma J, Gao X, Kelley J, et al. CAS PubMed Google Scholar Gao X-M, Wong G, Wang B, Kiriazis H, Moore X-L, Su Y-D, et al.
CAS PubMed Google Scholar Marin TM, Keith K, Davies B, Conner DA, Guha P, Kalaitzidis D, et al. CAS PubMed PubMed Central Google Scholar Chen X, Zeng S, Zou J, Chen Y, Yue Z, Gao Y, et al.
Google Scholar Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, et al. Article CAS PubMed Google Scholar Zhang W, He H, Song H, Zhao J, Li T, Wu L, et al.
Google Scholar Masini D, Bonito-Oliva A, Bertho M, Fisone G. Article PubMed PubMed Central Google Scholar Puighermanal E, Marsicano G, Busquets-Garcia A, Lutz B, Maldonado R, Ozaita A.
Article CAS PubMed Google Scholar Wang X, Seekaew P, Gao X, Chen J. CAS PubMed Google Scholar Liu W, Guo JN, Mu J, Tian L, Zhou D. Article CAS PubMed Google Scholar Yuan H, Wu G, Zhai X, Lu B, Meng B, Chen J. CAS PubMed PubMed Central Google Scholar Zhou M, Li W, Huang S, Song J, Kim Ju Y, Tian X, et al.
Article CAS PubMed PubMed Central Google Scholar Brewster AL, Lugo JN, Patil VV, Lee WL, Qian Y, Vanegas F, et al. CAS PubMed PubMed Central Google Scholar Lorne E, Zhao X, Zmijewski JW, Liu G, Park Y-J, Tsuruta Y, et al. CAS PubMed PubMed Central Google Scholar Li Z, Chen L, Sun Y, Li G. CAS PubMed Google Scholar Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, et al.
CAS PubMed PubMed Central Google Scholar Fielhaber JA, Carroll SF, Dydensborg AB, Shourian M, Triantafillopoulos A, Harel S, et al. CAS PubMed Google Scholar Goldberg EL, Romero-Aleshire MJ, Renkema KR, Ventevogel MS, Chew WM, Uhrlaub JL, et al. CAS PubMed Google Scholar Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV, Blagosklonny MV.
CAS PubMed Google Scholar Zhuo L, Cai G, Liu F, Fu B, Liu W, Hong Q, et al. CAS PubMed Google Scholar Leontieva OV, Demidenko ZN, Gudkov AV, Blagosklonny MV. At present, research on aging biology has focused on elucidating the biochemical and genetic pathways that contribute to aging over time.
Several aging mechanisms have been identified, primarily including genomic instability, telomere shortening, and cellular senescence. Aging is a driving factor of various age-related diseases, including neurodegenerative diseases, cardiovascular diseases, cancer, immune system disorders, and musculoskeletal disorders.
Thank you for visiting Metabolic health foods. You are using a browser age-rslated with limited support for Longevity and prevention of age-related diseases. To obtain the best experience, we recommend you use a more up to Lomgevity browser Sge-related turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic diseases, musculoskeletal diseases, and immune system diseases. Metrics Longevity and prevention of age-related diseases. Although the Longevty life expectancy is increasing dramatically, Longevity and prevention of age-related diseases healthy age-relafed is not going disaeses the same pace. This underscores the ager-elated of studies on the prevention of age-related diseases, Lohgevity order to satisfactorily decrease the Superfood detox diets, economic and social problems associated diaeases advancing age, related to an increased number of individuals not autonomous and affected by invalidating pathologies. In particular, data from experimental studies in model organisms have consistently shown that nutrient signalling pathways are involved in longevity, affecting the prevalence of age-related loss of function, including age-related diseases. Accordingly, nutrigerontology is defined as the scientific discipline that studies the impact of nutrients, foods, macronutrient ratios, and diets on lifespan, ageing process, and age-related diseases. To discuss the potential relevance of this new science in the attainment of successful ageing and longevity, three original studies performed in Sicily with local foods and two reviews have been assembled in this series.
0 thoughts on “Longevity and prevention of age-related diseases”