Artichoke cancer prevention properties -
Moreover, flavonoids share the same benefit as vitamin C. Another health benefit of artichokes is aiding in lowering blood pressure. A high level of sodium may result in increased blood pressure. Patients with high blood pressure or hypertension often have a potassium deficiency.
Therefore, you should increase potassium intake through your diet. Patients with diabetes should consume artichoke regularly to help prevent complications like high blood pressure.
Artichoke boosts cardiovascular health by helping to increase good cholesterol and reduce bad cholesterol. Cholesterol that builds up in the arteries may affect your cardiovascular system, increase blood pressure, block blood flow, and lead to fatal heart diseases and stroke. Magnesium Essentials also helps to reduce bad cholesterol in your body and protect your heart health, regularly consume fresh artichokes.
Artichokes have been considered a natural liver tonic for ages. These antioxidants are beneficial in promoting cell regrowth and repairing damaged liver cells. Because of essential nutrients, artichokes can help lower the risk of congenital disabilities.
Folic acid in this plant can help keep tube defects in newborns at bay. Artichoke is one of the healthiest superfoods globally as it is loaded with vital vitamins and essential minerals.
The essential minerals such as phosphorous, manganese, and magnesium can help increase bone density , promote overall bone health , and lower bone conditions like osteoporosis.
Manganese and magnesium are essential nutrients for the metabolic processes of the body. Magnesium increases the metabolic rates of amino acids, cholesterol, and carbohydrates.
Artichoke is beneficial for brain health. Eating artichokes can help to boost cognitive function by providing more oxygen to the brain. Phosphorous found abundant in artichokes can help prevent brain cell damage.
Phosphorous deficiency may lead to a decline in cognitive function. If you want to help keep your brain healthy, consider eating artichokes. Artichoke is one of the great foods for maintaining a healthy weight.
It is low in calories and fat. Therefore, you can eat this healthy food in ample proportions without worrying about weight gain. Moreover, artichoke is an excellent source of dietary fiber that can leave you feeling satisfied and help prevent overeating. Besides eating artichokes, you should have a healthy diet and lifestyle if you want to lose weight safely and effectively.
Artichoke is an excellent source of calcium, potassium, sulfur, and iron beneficial for health. Furthermore, the high fiber content in artichokes helps keep blood sugar levels stable. You can add fresh artichokes to salads. Alternatively, you can cook artichokes with other vegetables. It has been shown that artichoke leaf extract 2, 3, 4 can benefit the liver and assist with the regeneration of damaged tissue.
Moreover, it stimulates the production of bile 2 , which aids in the removal of harmful toxins from your body. IBS is an ailment that affects your digestive system and can make you experience stomach discomfort, cramping, diarrhea, bloating, constipation, and flatulence.
Artichoke leaf extract might help with IBS symptoms 2 when taken daily. Artichoke leaves have antispasmodic properties, which means they can aid in treating IBS muscle spasms. Even though artichoke extract appears beneficial for IBS discomfort, more extensive clinical trials are still required.
Artichokes can protect your digestive health. This versatile food is an excellent source of cynarine, an antioxidant that boosts the creation of bile and the absorption of fats and vitamins.
Artichoke is an excellent food for patients with dyspepsia and irritable bowel syndrome. Artichokes are a valuable and healthy food that you can include in your diet every day to stay healthy.
I hope this information about the health benefits of artichokes inspires you to make them part of your diet. Remember, a healthy, balanced diet is essential to keep numerous diseases at bay. Now is the time for you to make smart choices like artichoke! Discover more ways how you can include artichokes in your daily diet.
Get a FREE copy of my Superfood Cookbook. Partha Nandi M. is the creator and host of the internationally syndicated medical lifestyle television show, Ask Dr. A practicing physician and a renowned international speaker, his appearances include TEDx, college commencements, numerous charity functions, premier medical meetings such as Digestive Disease Week, and nationally syndicated television programs such as The Katie Couric Show.
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Blood disorders are conditions that affect red and white blood cells, and the smaller circulating cells known as platelets. All three cell types originate within the bone marrow, the soft tissue inside your bones, and blood disorders can prevent these cells from operating correctly.
Data obtained was analyzed using FlowJo version 7. For each sample, 2, events were collected gating on the FSC vs SCC dot plot and EGFP histogram plot. To analyze the agronomic variables in each cultivar, a t-test was used for variables with normal distribution, while a Kruskal-Wallis Test was used for those variables without normal distribution.
The statistical analyses were carried out by INFOSTAT software Di Rienzo et al. InfoStat versión Grupo InfoStat, FCA, Universidad Nacional de Córdoba, Argentina. A Chi square was applied to test the differences of caffeoylquinic acids mono- or di-caffeoylquinic acids in bracts and leaves within each cultivar and to compare total caffeoylquinic acid content among cultivars.
To perform a test of independence, the mean values of mono- and di-caffeoylquinic acids in the three cultivars were transformed to percentages.
The artichoke Gauchito GA , Guri GU and Oro Verde OV cultivars Figure 1 , show good productivity and high level of polyphenols. FIGURE 1 Representative images of plants first file , primary heads second file , and edible central bracts third file from three artichoke cultivars Gauchito, Guri and Oro Verde.
The total yield per plant in grams is Aumentando el espectro varietal en alcaucil Cynara scolymus L. New Argentinian Clones of Artichoke. Fresh leaves and bracts were selected to prepare the extracts for the chemical and biological characterizations. All ext racts were analyzed by l iquid chromatography-high resolution mass spectrometry LC-HRMS in negative mode, comparing the retention time Rt of the chromatogram peaks and their HRMS spectra with those corresponding to the analytical standards 1 5-caffeoylquinic acid or chlorogenic acid and 2 1,3-dicaffeoylquinic acid or cynarin , or with data reported in literature.
The chromatograms of bract extracts show peaks with retention time Rt at 6. Dicaffeoylquinic acids were detected at Rt Additionally, one peak at Rt All mentioned compounds have been previously described in other globe artichoke cultivars Abu-Reidah et al.
Extensive characterisation of bioactive phenolic constituents from globe artichoke Cynara scolymus L. by HPLC-DAD-ESI-QTOF-MS. Profile of polyphenols and phenolic acids in bracts and receptacles of globe artichoke Cynara cardunculus var.
scolymus germplasm. J Food Compos Anal. and were detected in bract extracts of GA, GU and OV Table I. Interestingly, four peaks with retention times of All compounds described in the studied extracts were previously reported in other artichoke genotypes.
The content of caffeoylquinic acids was determined in the extracts. The amount of monocaffeoylquinic acids was calculated as chlorogenic acid. Dicaffeoylquinic acids were calculated as 1,3 dicaffeoylquinic acid and the content in bracts was Dicaffeoylquinic acids could not be quantified in OV leaves.
The phenolic compounds present in artichoke have antioxidant activity Llorach et al. Artichoke Cynara scolymus L. by products as a potential source of health-promoting antioxidant phenolics.
Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. Free Radical Res. These natural antioxidants with redox properties are radical scavengers, reducing agents or hydrogen donators Jesionek, Majer-Dziedzic, Chroma, Jesionek W, Majer-Dziedzic B, Choma IM.
Separation, identification, and investigation of antioxidant ability of plant extract components using TLC, LC-MS, and TLC-DPPH. J Liq Chromatogr Rel Technol. Antioxidant activity of plant extracts containing phenolic compounds. RP-HPLC analysis of the phenolic compounds of plant extracts.
Investigation of their antioxidant capacity and antimicrobial activity. Free radical scavenging activity was studied in GA, GU and OV cultivars by TLC-DPPH assay.
The leaf and bract extract chromatograms showed several light yellow dots on the purple background in the middle region of the chromatogram, which correlates with the characteristic TLC retention factors of caffeoylquinic acids and flavonoids, indicating the presence of DPPH scavengers in the three cultivars Figure 2.
FIGURE 2 A DPPH-TLC autographic assay of leaf extracts from Gauchito GAL , Guri GUL and Oro Verde OVL left , and bract extracts from Gauchito GAB , Guri GUB and Oro Verde OVB right. B TLC chromatogram of GAB and GAL extracts versus chlorogenic acid 1 and Rutin, revealed with Natural Product-PEG reagents.
System solvent: ethyl acetate: formic acid: acetic acid: water On the other hand, neuroblastoma cells were treated with different concentrations of bract and leaf extracts of GA and GU cultivars or controls, and the cell viability was measured 72h after treatment.
The extracts of OV cultivar were not used in the biological experiments based on the low content of caffeoylquinic acids detected previously. The results revealed that GA and GU leaf extracts GAL and GUL respectively significantly reduced the number of live cells.
The concentration of mono- and di-caffeoylquinic acids in the leaf extracts at these dilutions was 0. When these extracts were assessed on normal cell proliferation, none of the extracts showed effect on cell viability Figure 4. None of these pure compounds reproduced the activity observed for the leaf extracts of GA and GU cultivars, suggesting that the activity is due to the presence of several compounds or bioactive non-phenolic compounds that were not identified in the extracts.
Even though a more comprehensive study is needed, these results reveal that the Argentinian GA and GU artichokes studied in this work have the potential to inhibit the viability of neuroblastoma cells without affecting viability of normal cells.
Therefore, both GA and GU cultivars could be good candidates for chemoprevention. FIGURE 3 Effect of Gauchito GA and Guri GU extracts on tumor cell viability. Cell viability was evaluated by MTS assay. Mean ± SD is represented for each sample.
FIGURE 4 Effect of Gauchito GA and Guri GU extracts on WISH human amnion cell viability. FIGURE 5 Effect of pure compounds on tumor cell viability. Control MeOH. The viability was evaluated by MTS assay. Finally, a cell based reporter gene assay RGA designed to evaluate compounds that potentially modulate IFN-I activity was used to seek additional biological benefits of the studied artichoke cultivars.
IFNs are central molecules of the immune system with pharmacological or pathological actions; finding natural compounds that modulate the action of IFN-I in order to overcome or control different diseases is a challenge that is attracting great attention in the drug discovery field.
Then, the percentage of EGFP expressing cells, quantified by flow cytometry, is directly correlated with IFN potency Bürgi et al. This inhibition is evidenced by the decrease of EGFP fluorescence due to reduced activation of IFN-I activity Bürgi et al.
This effect of the artichoke extracts on IFN-I activity offers a very promising basis to do a more extensive and comprehensive study about Argentinean artichoke extracts as potential natural candidates for treatment of those diseases caused by IFN-I overproduction or hyper-activation.
In this regard, it is interesting to note that chronic inflammation has been shown to cooperate with the development of several types of cancer Ben-Neriah, Karin, Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol.
In short, the three cultivars studied in this work have a good productive performance and present DPPH radical scavengers in their leaf and bract extracts.
LC-HRMS results for GA and GU cultivars show mono- and di-caffeoylquinic acids in both edible bracts and leaves, but only the leaves show higher diversity of flavonoids exerting a remarkable cytotoxic effect on SH-SY5Y neuroblastoma cells without affecting the proliferation of normal cells.
Moreover, GA and GU leaf extracts inhibit the action of IFN-I on a reporter cell line, suggesting their potential role as negative modulators of IFN-I biological function. Even though further research is needed, our results suggest that the Argentinean GA and GU artichoke cultivars may well be exploited in pharmaceutical formulations to prevent pathological human signals related to cancer and chronic inflammation.
The authors thank Universidad Nacional de Rosario and CONICET for the RR and PSC scholarships, and Agencia Santafesina de Ciencia, Tecnología e Innovación PIO and CONICET PIP for the financial support. Open menu Brazil. Brazilian Journal of Pharmaceutical Sciences. Submission of manuscripts About the journal Editorial Board Instructions to authors Contact.
Português Español. Open menu. table of contents « previous current next ». Text EN Text English. PDF Download PDF English. Abstract The aim of this work is to study three cultivars of artichoke Cynara cardunculus var.
MATERIAL AND METHODS Plant material The selected cultivars Gauchito GA , Gurí GU and Oro Verde OV , were grown at the experimental field of the College of Agronomic Sciences, National University of Rosario UNR , Zavalla, Santa Fe, Argentina 33º01´ S; 60º53´ W.
Experimental design and evaluated productive variables The crop was carried out in a soil Vertic Argiudoll. Collection of leaves and bracts for chemical and biological analysis The edible central bracts -between 21st and 30th in centripetal way-were collected from the primary heads.
Extract Preparation The frozen plant material 10 g was crushed adding liquid nitrogen, macerated with methanol mL, 30 min, rpm, 2 x at room temperature 25 °C. Cell culture and proliferation assay SH-SY5Y cells human neuroblastoma, ATCC CRL were used as sample for evaluation of the effect of extracts in cancer and WISH cells human amnion cells ATCC CCL were used as normal cells sample.
Analysis of extracts effect on the interferon activity The extracts were analyzed employing a previously developed cell based reporter gene assay RGA Bürgi et al.
Statistical analysis To analyze the agronomic variables in each cultivar, a t-test was used for variables with normal distribution, while a Kruskal-Wallis Test was used for those variables without normal distribution.
TABLE I Compounds detected by LC-HRMS in bract extracts and leaf extracts of Gauchito GA , Gurí GU and Oro verde OV cultivars. Agarwal R, Mukhtar H. Almeida D, Pinho R, Correia V, Soares J, Bastos ML, Carvalho F, et al. Ben-Neriah Y, Karin M. Bürgi M, Prieto C, Etcheverrigaray M, Kratje R, Oggero M, Bollati-Fogolín M.
Cointry E, García S, Lopez Anido F, Firpo I, Cravero V, Muñoz S. Cuendet M, Hostettmann K, Potterat O, Dyatmiko W. Iridoid glucosides with free radical scavenging properties from Fagvaea blumei Helv Chim Acta. Di Rienzo JA, Casanoves F, Balzarini MG, Gonzalez L, Tablada M, Robledo CW.
Food and Agricultural Organization FAO. García SM, Rotondo R, López Anido F, Cointry E, Santa Cruz P, Furlán RLE, et al. García SM, Rotondo R, López Anido F, Cointry E, Santa Cruz P, Furlán RLE, Escalante AM.
Gebhardt R. González-Sarrías A, Núñez-Sánchez M, Tomás-Barberán F, Espín J. Guilford JM, Pezzuto JM. Jesionek W, Majer-Dziedzic B, Choma IM. Kähkönen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala TS, et al. Lattanzio V, Kroon PA, Linsalata V, Cardinali A. Liu RH. Llorach R, Espin J, Tomás-Barberán F, Ferreres F.
Lombardo S, Pandino G, Ierna A, Mauromicale G. Lombardo S, Pandino G, Mauromicale G, Knödler M, Carle R, Schieber A.
Influence of genotype, harvest time and plant part on polyphenolic composition of globe artichoke [ Cynara cardunculus L. Lopez Anido F, Cointry E, Cravero V. Martínez-Esplá A, García-Pastor M, Zapata P, Guillen F, Serrano M, Valero D, et al. Mehta RG, Murillo G, Naithani R, Peng X.
Miccadei S, Di Venere D, Cardinali A, Romano F, Durazzo A, Foddai MS, et al. Mileo A, Di Venere D, Linsalata V, Fraioli R, Miccadei S. Newman DJ, Cragg GM. Pagnotta MA, Fernández JA, Sonnante G, Egea-Gilabert C. Pandino G, Lombardo S, Mauromicale G, Williamsom G.
Pandino G, Lombardo S, Mauromicale G. Perez-Garcia F, Adzet T, Cañigueral S. Proestos C, Chorianopoulos N, Nychas GJE, Komaitis M. Pulito C, Mori F, Sacconi A, Casadei L, Ferraiuolo M, Valerio M, et al. Tan AC, Konczak I, Sze DM, Ramzan I. World Health Organization. Publication Dates Publication in this collection 23 May Date of issue History Received 08 Mar Accepted 27 Aug This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Rosana Rotondo College of Agronomical Sciences, National University of Rosario, Zavalla, Santa Fe, Argentina National University of Rosario Argentina Zavalla, Santa Fe, Argentina College of Agronomical Sciences, National University of Rosario, Zavalla, Santa Fe, Argentina.
Pablo Santa Cruz College of Biochemical and Pharmaceutical Sciences, National University of Rosario, UNR-CONICET, Rosario, Santa Fe, Argentina National University of Rosario, UNR-CONICET Argentina Rosario, Santa Fe, Argentina College of Biochemical and Pharmaceutical Sciences, National University of Rosario, UNR-CONICET, Rosario, Santa Fe, Argentina.
Marianela Masin Institute for Molecular Biology of Rosario IBR , UNR-CONICET, Rosario, Santa Fe, Argentina UNR-CONICET Argentina Rosario, Santa Fe, Argentina Institute for Molecular Biology of Rosario IBR , UNR-CONICET, Rosario, Santa Fe, Argentina.
College of Biochemistry and Biological Sciences, National University of Litoral, UNL-CONICET, Santa Fe, Argentina National University of Litoral, UNL-CONICET Argentina Santa Fe, Argentina College of Biochemistry and Biological Sciences, National University of Litoral, UNL-CONICET, Santa Fe, Argentina.
Milagros Bürgi College of Biochemistry and Biological Sciences, National University of Litoral, UNL-CONICET, Santa Fe, Argentina National University of Litoral, UNL-CONICET Argentina Santa Fe, Argentina College of Biochemistry and Biological Sciences, National University of Litoral, UNL-CONICET, Santa Fe, Argentina.
Javier Girardini Institute for Molecular Biology of Rosario IBR , UNR-CONICET, Rosario, Santa Fe, Argentina UNR-CONICET Argentina Rosario, Santa Fe, Argentina Institute for Molecular Biology of Rosario IBR , UNR-CONICET, Rosario, Santa Fe, Argentina.
Stella M. García College of Agronomical Sciences, National University of Rosario, Zavalla, Santa Fe, Argentina National University of Rosario Argentina Zavalla, Santa Fe, Argentina College of Agronomical Sciences, National University of Rosario, Zavalla, Santa Fe, Argentina.
Gustavo R. Rodríguez Institute of Research in Agronomical Sciences of Rosario IICAR , UNR-CONICET. College of Agronomical Sciences, Zavalla, Santa Fe, Argentina UNR-CONICET Argentina Zavalla, Santa Fe, Argentina Institute of Research in Agronomical Sciences of Rosario IICAR , UNR-CONICET.
College of Agronomical Sciences, Zavalla, Santa Fe, Argentina. Ricardo L. Furlan College of Biochemical and Pharmaceutical Sciences, National University of Rosario, UNR-CONICET, Rosario, Santa Fe, Argentina National University of Rosario, UNR-CONICET Argentina Rosario, Santa Fe, Argentina College of Biochemical and Pharmaceutical Sciences, National University of Rosario, UNR-CONICET, Rosario, Santa Fe, Argentina.
Andrea M. Facultad de Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario.
Potential benefits of orevention extract may include helping with Artichoke cancer prevention properties issues cancfr reducing cholesterol. Artlchoke evidence suggests few side effects, more research is necessary propertise confirm these benefits. Guarana health benefits Artichoke cancer prevention properties choose to use artichoke extract for liver and digestive health, inflammationor to treat conditions that have not responded well to traditional care. As with most forms of herbal medicine, artichoke extract relies on alternative medicine principles that lack conclusive scientific evidence. No data suggest that it can replace standard medical care for any condition. The safest way to use artichoke extract is as a complement to traditional care. The aim of preventlon work is to Artichoke cancer prevention properties three cultivars of artichoke Cynara cardunculus var. scolymus : Gauchito, Guri and Oro Prevenyion in terms of their Artichokke Artichoke cancer prevention properties chemoprevention and anti-inflammatory properties. These cultivars show good productive performance. The phenolic composition of their fresh leaves and edible bracts was analyzed by high performance liquid chromatography and high resolution mass spectrometry HPLC-HRMSshowing mainly caffeoylquinic acids and flavonoids. Caffeoylquinic acids were quantified and the highest content was found in Gauchito cultivar.
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