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GIP is thought to improve how the body breaks down sugar; glucagon may reduce appetite and help metabolism run more efficiently. Holly Lofton, the director of the weight management program at NYU Langone Health.
She was not involved with the trial, although she has previously served on an advisory board for Ozempic and Wegovy-maker Novo Nordisk. The drug was given as a weekly injection. Participants had a body mass index , or BMI, of 27 or greater.
The results published Monday did not include patients with Type 2 diabetes, a group that is also prescribed GLP-1 medications because of their effects on blood sugar levels.
A separate trial is looking at retatrutide for patients with Type 2 diabetes. After 24 weeks, patients taking the highest dose — 12 milligrams — lost, on average, By 48 weeks, the weight loss increased to Ania Jastreboff, an obesity medicine physician scientist at Yale University School of Medicine and the lead author on the phase 2 study.
Jucynthia Jessie, 44, of Laplace, Louisiana, participated in the trial and lost 60 pounds. Weight loss in the trial seemed to happen quicker than other weight loss medications, according to Jastreboff.
To be sure, these are not direct comparisons because the drugs were not compared in a head-to-head clinical trial. Fatima Cody Stanford, a physician specializing in obesity at Massachusetts General Hospital in Boston, said that when patients lose weight very quickly — more than 10 pounds a month — they can be at risk for developing gallstones.
In clinical trials, tirzepatide and semaglutide have also been associated with a small but slightly increased risk of gallbladder disease, including gallstones. The speed of the weight loss seen with retatrutide was not a concern to Lofton. The side effects of retatrutide were similar to other weight loss medications, Skovronky said.
Side effects from Ozempic and Wegovy, for example, include nausea, vomiting, diarrhea and constipation. Generally, people experience those side effects as they ramp up the dosage at the start of treatment, but the side effects usually go away after prolonged use.
Jastreboff agreed. Given its potency, it could also be useful for people who need to lose a substantial amount of weight, she said.
The company has started enrolling participants in a larger phase 3 clinical trial, which will include thousands of participants. The trial is expected to be completed in December , according to clinicaltrials.
Skovronsky said he hopes that retatrutide could one day provide the same levels of weight loss seen with bariatric surgery. He also said that retatrutide and drugs like it could potentially be used to treat obstructive sleep apnea as well as decrease the risk of heart disease.
Berkeley Lovelace Jr. is a health and medical reporter for NBC News. He covers the Food and Drug Administration, with a special focus on Covid vaccines, prescription drug pricing and health care. He previously covered the biotech and pharmaceutical industry with CNBC. IE 11 is not supported.
com, ReadersDigest. com, TheHealthy. com, Prevention. com, WomensHealthMag. com and more. On the heels of celeb tales about their experiences with Ozempic —and the fact that the shot originally developed to help treat type 2 diabetes was experiencing shortages due to its popularity—the conversation around this weekly shot and diet pills and supplements have reached a fever pitch.
That's why, in January , the American Academy of Pediatrics announced new guidelines about how doctors might consider treating children whose body mass index BMI qualifies them as having obesity.
If pediatricians follow these recommendations, kids as young as 12 could be prescribed "obesity weight-loss pharmacotherapy, according to medication indications, risks and benefits, as an adjunct to health behavior and lifestyle treatment. With teens and adults as the target market for weight-loss medications and diet pills, read along to learn about this complex and controversial topic.
Two very different types of medicines fall under the umbrella of diet pills or weight-loss medications. First, the prescription weight-loss shots and pills you get from a health care provider, which are regulated by the Food and Drug Administration and require clinical trials to support their efficacy and safety.
And second, the over-the-counter supplements and diet pills that aren't regulated by the FDA, which often claim to rev metabolism or "detox" the body. have tried a weight-loss supplement at some point in their lives, and even more are hopping on the prescription Ozempic train.
They often promote appetite suppression, a reduction in dietary fat absorption, decreased cravings or by increasing the sense of fullness," explains Pedro Leon, RDN, LDN , a clinical dietitian for Northwest Community Healthcare in Arlington Heights, Illinois.
FDA-approved options are generally recognized as safe when used as prescribed, according to Leon, and the American Heart Association and the American College of Cardiology report that these weight-loss medications can work. Some people who start Ozempic may have a challenging relationship with food.
By addressing that first, the need for these medications would decrease," and the health outcomes would likely be more sustainable over the long term. As far as those infomercial-promoted diet pills that often take up prime real estate at pharmacies and supplement shops, the Government Accountability Office concluded that "little information on potential safety concerns from dietary supplement AERs [adverse event reports] is publicly available and accessible to consumers, health care practitioners, and others.
Especially among the less-regulated mail-order and over-the-counter options, "These can interact or interfere with certain medications, so you should always speak to your health care provider about potential benefits and risks before starting any supplement or medication," Scott says.
Definitely proceed with caution and don't use these without medical supervision, especially if you have any conditions such as high blood pressure, diabetes, depression, liver disease or heart disease, or if you're pregnant, breastfeeding, have digestion issues or have a history of disordered eating.
If you have weight-loss goals, your best bet, according to Roxana Ehsani, M. It's also helpful to consider your "why. Ahead, a debrief on the aforementioned Ozempic and some other frequently advertised diet pills.
Although the celeb headlines speak to its use as a weight-loss medication, Ozempic semaglutide was originally developed for people with type 2 diabetes to help them manage their blood sugar and A1C levels. This class of medicines, GLP-1 agonists , works by increasing the amount of insulin produced by the pancreas and decreasing the amount of glucagon produced by the liver—essentially reducing hunger.
In a study published in March in The New England Journal of Medicine , researchers found that after 68 weeks of weekly injections, participants decreased body weight by So with that being the case, semaglutide is marketed by the brand name Wegovy when prescribed for weight loss among those who haven't been diagnosed with type 2 diabetes.
Leon adds that more independent studies are needed to determine a successful long-term solution. Some common side effects have been reported, such as nausea and diarrhea. Other FDA-approved weight-loss shots and pills include Contrave, Qsymia, Saxenda and orlistat.
Speaking of orlistat common brands include Xenical and Alli , since it also ranks among the most popular weight-loss medications, we'll dive deeper here, too. The unabsorbed fat exits the body through the stool," Ehsani clarifies.
Since this is the mechanism, this FDA-approved medication can cause gas, loose stools, oily or fatty stools, difficulty controlling bowel movements, irregular menstrual periods in females and oily spotting on clothing.
Not only that, orlistat may lead to difficulty breathing or swallowing, itching, rash, hives, excessive weakness, vomiting or yellowing of the skin or eyes, Ehsani says. According to StatPearls , it may also impact the absorption of other important medications taken by those who have experienced blood clots, organ transplants, irregular heart rhythms and more.
Clearly, serious matters. It's not just found in coffee, tea, chocolate and energy drinks anymore. In the short-term, it can have a small positive effect, but no substantial evidence shows that it helps long-term," Leon says. What we do know about the long haul, however, is that high consumption of caffeine supplements appears to actually contribute to weight gain, hormone imbalance, increased blood pressure, insulin resistance and sleep disturbance.
So enjoy your cup of coffee in the morning if you like, but know that studies don't support consuming caffeine in supplements as a long-term weight-loss solution. High doses of caffeine found in caffeine diet pills can be fatal, Ehsani continues, and can be especially harmful to teens, young adults and anyone sensitive to the effects of caffeine.
It may also cause side effects such as anxiety, sleep issues like insomnia, dehydration, digestive issues, rapid heart rate, diarrhea or vomiting. Like the tea it shares its name with, green tea extract is rich in catechins, antioxidants and caffeine.
Leon explains that the latter's thermogenic calorie-burning effect has been promoted as a way to increase energy expenditure and fat oxidation.
However, if consumed in high doses or for an extended period, green tea extract can cause gastrointestinal side effects like nausea, vomiting, diarrhea and abdominal pain.
Beyond that, excess green tea extract can lead to serious issues, including heart palpitations and liver damage or failure. It's best to enjoy your green tea for its healthy, antioxidant benefits," Leon says. If you follow his guidance and sip green tea instead of a supplement, you might score some blood sugar and inflammation-taming benefits.
For this diet pill, manufacturers sell an extract made from coffee beans that have not been roasted. Again, it provides a source of caffeine, which can increase resting metabolic rate and fat metabolism.
The levels of chlorogenic acids found in green coffee bean extract are also said to reduce carbohydrate absorption in the digestive tract. Also, there isn't a dosage amount for green coffee bean extract, so it's hard to say what amount is OK compared to what amount is unhealthy and dangerous to health," Ehsani says.
Conjugated linoleic acid CLA is a fatty acid naturally found in food like beef and dairy products. In diet pill form, CLA marketers claim that it can help burn body fat and, as a result, lead to weight loss.
Among people, the results were not clear, and people only lost 1 pound over the course of a week study. There's very little evidence showing it actually helps or works. More research studies need to be conducted before I'd recommend this," Ehsani says. Side effects of CLA supplementation can trigger inflammation.
Additionally, it may lead to liver enlargement, insulin resistance, abdominal discomfort and pain, constipation or diarrhea, and adverse effects on blood lipids, Leon and Scott add. Marketed for weight loss and as a "fat burner," Hydroxycut was originally released with a combination of caffeine and ephedra.
Lods DIEGO — An experimental drug from Eli Lilly has the pil,s to provide greater weight loss lills than any drug currently Flaxseeds for reducing cravings the Glycogen replenishment during high-intensity training. Losw Glycogen replenishment during high-intensity training lkss simultaneously Glycogen replenishment during high-intensity training in The New England Journal of Stronh. If the results are confirmed in a larger, phase 3 clinical trial — which is expected to run until late — retatrutide could leapfrog another Lilly weight loss drug, tirzepatide, which experts estimated earlier this year could become the best-selling drug of all time. Tirzepatide is currently approved for Type 2 diabetes under the name Mounjaro; FDA approval of the drug for weight loss is expected this year or early next year. The new findings, according to Dr. Weigt include products we pllls Glycogen replenishment during high-intensity training useful for our readers. If you buy through links on this page, we may wright a small weiight. Healthline only shows you brands and products that Strong weight loss pills stand behind. Prescription weight loss WHR and overall health, including GLP-1 agonists, orlistat, and setmelanotide, may be effective for some people. But other lifestyle changes are still necessary for long-term success. When paired with other lifestyle changes and taken under the supervision of a healthcare professional, these drugs may offer an effective way to lower your weight. We reviewed all of the weight loss medications that are currently available, including how they work, who they might be appropriate for, research on their effectiveness, and potential safety concerns.Mayo Clinic offers tSrong in Arizona, Florida and Minnesota and Herbal body detox Mayo Clinic Health System Los. Is Alli — an over-the-counter weight-loss pill — the solution to your weight-loss woes?
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Alli can reduce the absorption of fat-soluble nutrients, including beta carotene and vitamins A, D, E and K. Take a multivitamin at least two hours after your last dose of Alli. For some people, this timing works out best to be at bedtime. The active ingredient in Alli, orlistat, causes digestive side effects related to undigested fats passing through your digestive system.
They generally lessen over time and with proper use of the drug. These side effects include:. Before taking Alli, talk with your health care provider about possible interactions with other drugs, particularly if you take drugs for any of the following conditions:.
A weight-loss plan with diet, exercise and drug therapy is generally considered successful if you lose about 1 pound 0. If the treatment is successful, you are more likely to keep weight off or lose more weight if you continue with the diet, exercise and drug treatment plan.
Most weight loss with the drug occurs within the first few months. The risks, side effects and cost related to taking the drug likely override any potential benefit.
Alli isn't an easy answer to weight loss. Losing weight and keeping it off require a commitment to eat a healthy, calorie-controlled diet and get regular physical activity.
Work with your health care provider to evaluate the potential benefits and risks of Alli or any other weight-loss drugs. As a team, you and your provider can create the right weight-loss plan for you.
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Show references Frequently asked questions Alli. Accessed Feb. IBM Micromedex. Orlistat oral. Perreault L. Obesity in adults: Drug therapy. Position of the Academy of Nutrition and Dietetics: Interventions for the treatment of overweight and obesity in adults.
Journal of the Academy of Nutrition and Dietetics. Khera R, et al. Association of pharmacological treatments for obesity with weight loss and adverse events: A systematic review and meta-analysis. Xenical prescribing information. Genentech; Products and Services The Mayo Clinic Diet Online A Book: The Mayo Clinic Diet Bundle.
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: Strong weight loss pills| Main Content | How It Works Phentermine and topiramate in Qsymia work together to alter neurotransmitter levels to decrease appetite and cravings, according to research. These choices will be signaled to our partners and will not affect browsing data. Mild side effects, such as nausea, constipation and diarrhea, are common. Both Alli and Xenical are meant to be used as part of a weight-loss plan, along with a low-calorie, low-fat diet and regular physical activity. What the Research Says One week study showed those taking Orlistat lost 5. If you answered yes to these questions, a prescription weight-loss drug may be a choice for you. |
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LeWine, MD , Chief Medical Editor, Harvard Health Publishing Some people who struggle with weight loss have been able to find assistance from several FDA-approved weight-loss medications, such as bupropion plus naltrexone Contrave , phentermine Adipex-P , phentermine plus topiramate Qsymia , and orlistat Xenical, Alli. Research health conditions Check your symptoms Prepare for a doctor's visit or test Find the best treatments and procedures for you Explore options for better nutrition and exercise Learn more about the many benefits and features of joining Harvard Health Online ». Sign Me Up. About the Author. About the Reviewer. FDA-approved options are generally recognized as safe when used as prescribed, according to Leon, and the American Heart Association and the American College of Cardiology report that these weight-loss medications can work. Some people who start Ozempic may have a challenging relationship with food. By addressing that first, the need for these medications would decrease," and the health outcomes would likely be more sustainable over the long term. As far as those infomercial-promoted diet pills that often take up prime real estate at pharmacies and supplement shops, the Government Accountability Office concluded that "little information on potential safety concerns from dietary supplement AERs [adverse event reports] is publicly available and accessible to consumers, health care practitioners, and others. Especially among the less-regulated mail-order and over-the-counter options, "These can interact or interfere with certain medications, so you should always speak to your health care provider about potential benefits and risks before starting any supplement or medication," Scott says. Definitely proceed with caution and don't use these without medical supervision, especially if you have any conditions such as high blood pressure, diabetes, depression, liver disease or heart disease, or if you're pregnant, breastfeeding, have digestion issues or have a history of disordered eating. If you have weight-loss goals, your best bet, according to Roxana Ehsani, M. It's also helpful to consider your "why. Ahead, a debrief on the aforementioned Ozempic and some other frequently advertised diet pills. Although the celeb headlines speak to its use as a weight-loss medication, Ozempic semaglutide was originally developed for people with type 2 diabetes to help them manage their blood sugar and A1C levels. This class of medicines, GLP-1 agonists , works by increasing the amount of insulin produced by the pancreas and decreasing the amount of glucagon produced by the liver—essentially reducing hunger. In a study published in March in The New England Journal of Medicine , researchers found that after 68 weeks of weekly injections, participants decreased body weight by So with that being the case, semaglutide is marketed by the brand name Wegovy when prescribed for weight loss among those who haven't been diagnosed with type 2 diabetes. Leon adds that more independent studies are needed to determine a successful long-term solution. Some common side effects have been reported, such as nausea and diarrhea. Other FDA-approved weight-loss shots and pills include Contrave, Qsymia, Saxenda and orlistat. Speaking of orlistat common brands include Xenical and Alli , since it also ranks among the most popular weight-loss medications, we'll dive deeper here, too. The unabsorbed fat exits the body through the stool," Ehsani clarifies. Since this is the mechanism, this FDA-approved medication can cause gas, loose stools, oily or fatty stools, difficulty controlling bowel movements, irregular menstrual periods in females and oily spotting on clothing. Not only that, orlistat may lead to difficulty breathing or swallowing, itching, rash, hives, excessive weakness, vomiting or yellowing of the skin or eyes, Ehsani says. According to StatPearls , it may also impact the absorption of other important medications taken by those who have experienced blood clots, organ transplants, irregular heart rhythms and more. Clearly, serious matters. It's not just found in coffee, tea, chocolate and energy drinks anymore. In the short-term, it can have a small positive effect, but no substantial evidence shows that it helps long-term," Leon says. What we do know about the long haul, however, is that high consumption of caffeine supplements appears to actually contribute to weight gain, hormone imbalance, increased blood pressure, insulin resistance and sleep disturbance. So enjoy your cup of coffee in the morning if you like, but know that studies don't support consuming caffeine in supplements as a long-term weight-loss solution. High doses of caffeine found in caffeine diet pills can be fatal, Ehsani continues, and can be especially harmful to teens, young adults and anyone sensitive to the effects of caffeine. It may also cause side effects such as anxiety, sleep issues like insomnia, dehydration, digestive issues, rapid heart rate, diarrhea or vomiting. Like the tea it shares its name with, green tea extract is rich in catechins, antioxidants and caffeine. Leon explains that the latter's thermogenic calorie-burning effect has been promoted as a way to increase energy expenditure and fat oxidation. However, if consumed in high doses or for an extended period, green tea extract can cause gastrointestinal side effects like nausea, vomiting, diarrhea and abdominal pain. Beyond that, excess green tea extract can lead to serious issues, including heart palpitations and liver damage or failure. It's best to enjoy your green tea for its healthy, antioxidant benefits," Leon says. If you follow his guidance and sip green tea instead of a supplement, you might score some blood sugar and inflammation-taming benefits. For this diet pill, manufacturers sell an extract made from coffee beans that have not been roasted. Again, it provides a source of caffeine, which can increase resting metabolic rate and fat metabolism. The levels of chlorogenic acids found in green coffee bean extract are also said to reduce carbohydrate absorption in the digestive tract. Also, there isn't a dosage amount for green coffee bean extract, so it's hard to say what amount is OK compared to what amount is unhealthy and dangerous to health," Ehsani says. Conjugated linoleic acid CLA is a fatty acid naturally found in food like beef and dairy products. In diet pill form, CLA marketers claim that it can help burn body fat and, as a result, lead to weight loss. Most Wished For in Fat Burner Supplements. Gift Ideas in Fat Burner Supplements. Essential Fatty Acids. Black Currant Oil. Black Seed Oil. Fat Burners. Fish Oil. Flax Seed Oil. Krill Oils. Linseed Oil. Omega Oils. Your recently viewed items and featured recommendations. Back to top. Get to Know Us. Make Money with Us. Amazon Payment Products. Let Us Help You. Conditions of Use Privacy Notice Your Ads Privacy Choices © , Amazon. com, Inc. or its affiliates. Amazon Music Stream millions of songs. Amazon Ads Reach customers wherever they spend their time. ACX Audiobook Publishing Made Easy. |
| Best Weight Loss Supplements Top 5 Products | Error Email field is required. Error Include a valid email address. To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. This content does not have an English version. This content does not have an Arabic version. Appointments at Mayo Clinic Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Request Appointment. Healthy Lifestyle Weight loss. Sections Basics Weight-loss basics Diet plans The Mayo Clinic Diet Diet and exercise Diet pills, supplements and surgery In-Depth Expert Answers Multimedia Resources News From Mayo Clinic What's New. Products and services. Alli weight-loss pill: Does it work? By Mayo Clinic Staff. Thank you for subscribing! Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. Show references Frequently asked questions Alli. Accessed Feb. IBM Micromedex. Orlistat oral. Perreault L. Obesity in adults: Drug therapy. Position of the Academy of Nutrition and Dietetics: Interventions for the treatment of overweight and obesity in adults. Journal of the Academy of Nutrition and Dietetics. Khera R, et al. Association of pharmacological treatments for obesity with weight loss and adverse events: A systematic review and meta-analysis. Xenical prescribing information. Genentech; Products and Services The Mayo Clinic Diet Online A Book: The Mayo Clinic Diet Bundle. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Mayo Clinic on Incontinence - Mayo Clinic Press Mayo Clinic on Incontinence The Essential Diabetes Book - Mayo Clinic Press The Essential Diabetes Book Mayo Clinic on Hearing and Balance - Mayo Clinic Press Mayo Clinic on Hearing and Balance FREE Mayo Clinic Diet Assessment - Mayo Clinic Press FREE Mayo Clinic Diet Assessment Mayo Clinic Health Letter - FREE book - Mayo Clinic Press Mayo Clinic Health Letter - FREE book. ART Healthy Lifestyle Weight loss In-Depth Alli weight loss pill Does it work. Show the heart some love! Give Today. Help us advance cardiovascular medicine. Find a doctor. Explore careers. Sign up for free e-newsletters. About Mayo Clinic. About this Site. Contact Us. Health Information Policy. Media Requests. News Network. Price Transparency. Medical Professionals. Clinical Trials. Mayo Clinic Alumni Association. Refer a Patient. Executive Health Program. International Business Collaborations. Cantor Fitzgerald analyst Louise Chen told CNBC that orforglipron could potentially achieve an even greater level of weight loss over a longer trial period. The company's phase three clinical trials on orforglipron will study the drug over longer time periods. At least for now, analysts say Eli Lilly's pill may also have the upper hand over Pfizer's oral GLP-1, danuglipron , which is still in phase two clinical trials. Patients with Type 2 diabetes who took a milligram version of danuglipron twice a day lost around 10 pounds on average after 16 weeks, according to results from one phase two clinical trial. It's difficult to compare danuglipron's efficacy with that of other oral GLP-1s due to differing patient populations and the lack of longer-term data on the drug. A Pfizer spokesperson told CNBC that the company is still studying the drug in further phase two clinical trials and "would also look to have longer data" beyond the week mark in the future. Wells Fargo analyst Mohit Bansal said in a research note that Pfizer's danuglipron will be challenged to compete in the oral GLP-1 space given Eli Lilly's strong orforglipron data. He added that physicians generally prefer once-daily pills — like orforglipron — over twice-daily drugs such as danuglipron. Health experts seem to agree: "Patient compliance increases a lot if it's a once-a-day pill, so it's definitely a big advantage. People often end up missing a few times a week if they have to take something twice a day," said Dr. John Yoon , an endocrinology professor at UC Davis Health. The company on Monday also said it would stop developing another experimental pill, lotiglipron, which Bansal said had been the "more attractive GLP-1" in Pfizer's portfolio since it's only taken once a day. But Pfizer and Eli Lilly do share one key advantage over Novo Nordisk's oral semaglutide: no dietary restrictions. Patients need to take Novo Nordisk's oral semaglutide in the morning on an empty stomach with no more than four ounces of plain water, according to the FDA label for the low-dose, approved version of the drug. They're instructed to wait 30 minutes before eating, drinking or taking other oral medicines. That's because Novo Nordisk's oral semaglutide is a peptide medication, which is more difficult for the gut to absorb, according to Dr. Eduardo Grunvald , medical director for UC San Diego's Center for Advanced Weight Management. He said pills from Eli Lilly and Pfizer are non-peptide GLP-1s, which are absorbed more easily and don't require dietary restrictions. Cantor Fitzgerald's Chen said market research suggests that those restrictions are a "big negative for patients," making the pills from Eli Lilly and Pfizer convenient alternatives. Overall, Eli Lilly's orforglipron appears to be the top contender in the weight loss pill space due to its strong efficacy data and convenience as a once-daily pill without dietary restrictions. But Chen emphasized that the data unveiled later this year could potentially change that: "Save some room for the new data coming. For health experts such as Grunvald, naming a winner in the oral weight loss drug space is less important. Skip Navigation. CNBC TV. Investing Club. Key Points. Drugmakers are jockeying to capitalize on the next major innovation coming to the blockbuster weight loss industry. |
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