Time-restricted eating protocol -
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This work was supported by grants from the CAMS Innovation Fund for Medical Sciences CIFMS No. and H. The study sponsors played no role in study design, conduct, data acquisition, analysis, manuscript preparation or the decision to submit the manuscript for publication. We thank Mark Cleasby, PhD from Liwen Bianji Edanz www.
cn for editing the language of a draft of this manuscript. Department of Hepatobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
You can also search for this author in PubMed Google Scholar. oversaw the design, regulatory compliance, execution, and data analyses in this study.
designed the study. Zhang, Z. Zhao, and H. recruited participants, collected data, and monitored participants compliance. All the authors contributed to data analyses. wrote the manuscript. All the authors contributed to the composition and revision of the manuscript and gave final approval to its content.
Correspondence to Huayu Yang or Yilei Mao. Nature Communications thanks Heather Allore, Marta Garaulet and the other anonymous reviewer s for their contribution to the peer review this work. Peer reviewer reports are available. Open Access This article is licensed under a Creative Commons Attribution 4.
Reprints and permissions. Xie, Z. Randomized controlled trial for time-restricted eating in healthy volunteers without obesity. Nat Commun 13 , Download citation. Received : 18 January Accepted : 03 February Published : 22 February Anyone you share the following link with will be able to read this content:.
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Download PDF. Subjects Feeding behaviour Nutrition Obesity Pre-diabetes. Abstract Time-restricted feeding TRF improves metabolic health.
Introduction Long-term dietary habits are determinants of metabolic health 1. Results Participants Ninety volunteers who met the eligibility criteria participated in the trial and were randomized at a ratio of to eTRF, mTRF, and control groups Fig. Full size image. Table 1 Baseline Characteristics.
Full size table. Discussion The present study has shown that 5 weeks of eTRF, but not mTRF, improves insulin sensitivity, reduces fasting plasma glucose, reduces body mass and adiposity, ameliorates inflammation, and increases gut microbial diversity. Randomization procedure For the pilot RCT, participants were randomly assigned to either the eTRF, mTRF, or control group in a ratio, using a computer-based random-number generator by designated researchers.
Inclusion and exclusion criteria The inclusion criteria were: 1 18—64 years old; 2 ability to attend the hospital at regular intervals; 3 ability to independently provide informed consent; 4 BMI between Anthropometric measurements Body mass and percentage body fat were measured using an HBF Bioelectrical impedance analyzer Omron Healthcare Co.
Blood sampling and storage Blood sampling was performed at the beginning and the end of the trial. Flow cytometric analysis PBMCs were separated from blood samples using Ficoll GE Healthcare, Chicago, IL and centrifugation. Fecal sample collection and storage Fecal samples were collected during the 3 days before the start of the trial and during the same period of time before the end of the trial.
Biochemical measurements The plasma activities of AST, ALT, ALP, GGT, and lactate dehydrogenase; and the concentrations of LDL-C, HDL-C, total cholesterol, triglyceride, and glucose were measured using an automated analyzer Beckmann-Coulter AU , Brea, CA.
Real-time quantitative PCR RNA was pooled from PBMCs and used for cDNA synthesis. Subjective sleep quality and eating habits The participants were required to maintain their normal sleeping habits throughout the trial and to avoid undergoing testing after a night shift.
Statistical analysis For the sample size calculation, we estimated that the eTRF group would show a Data availability The individual de-identified participant microbiota metagenomic sequencing data can be accessed from the BioProject Database of National Centre for Biotechnology Information with the dataset accession number PRJNA Code availability No code was involved in this manuscript.
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Article CAS PubMed Google Scholar Refinetti, R. Acknowledgements This work was supported by grants from the CAMS Innovation Fund for Medical Sciences CIFMS No. Author information Author notes These authors contributed equally: Zhibo Xie, Yuning Sun, Yuqian Ye. View author publications.
Ethics declarations Competing interests The authors declare no competing interests. Peer review Peer review information Nature Communications thanks Heather Allore, Marta Garaulet and the other anonymous reviewer s for their contribution to the peer review this work.
Supplementary information. Supplementary Information. Peer Review File. Reporting Summary. Source data Source Data. Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.
About this article. Cite this article Xie, Z. Copy to clipboard. McHill Kenneth P. Wright Nature Reviews Endocrinology Time-restricted eating with calorie restriction on weight loss and cardiometabolic risk: a systematic review and meta-analysis Jing-Chao Sun Zhen-Tao Tan Gang Qian European Journal of Clinical Nutrition Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis Susana Rovira-Llopis Clara Luna-Marco Victor M.
Victor Reviews in Endocrine and Metabolic Disorders Intermittent fasting and Alzheimer's disease—Targeting ketone bodies as a potential strategy for brain energy rescue Yu- Cai Ye Shi-Fan Chai Zhao-Jun Wang Metabolic Brain Disease Anyone who has any concerns or experiences any adverse effects of the diet should consult a doctor.
While evidence indicates that the method may be helpful for diabetes prevention, it may not be suitable for those who already have the condition. The intermittent fasting diet is generally not suitable for people with type 1 diabetes. Additionally, many forms of religious fasting list type 1 diabetes as an exemption due to the potential health risks.
People with diabetes who wish to try the intermittent fasting plan should see a healthcare professional before making changes to their eating habits. The intermittent fasting plan is a time-restricted form of intermittent fasting. It involves an 8-hour window for food consumption and fasting for 16 hours.
Potential benefits may include weight loss, fat loss, and a reduction in the risk of some diseases. People doing intermittent fasting should focus on eating high fiber whole foods and staying hydrated throughout the day.
The plan is not right for everyone. Individuals who wish to follow the intermittent fasting diet should speak with a doctor or dietitian if they have any concerns or underlying health conditions. Intermittent fasting is a diet plan that means consuming few to no calories on fasting day and eating normally on nonfasting days.
We look at the…. Intermittent fasting has many potential benefits. Tips to start include having a goal and choosing a suitable method. In this Behind the Counter, Dr.
Kelly Wood discusses the impact of intermittent fasting on type 2 diabetes, along with the potential benefits and…. Recent research suggests that following the Atlantic diet, which is similar to the Mediterranean diet, may help prevent metabolic syndrome and other….
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Medical News Today. Health Conditions Health Products Discover Tools Connect. A guide to intermittent fasting. Medically reviewed by Kathy W.
Warwick, R. About How to do it Tips Health benefits Side effects and risks Diabetes Summary The intermittent fasting plan is a form of time-restricted fasting that may help with weight loss. What is intermittent fasting? How to do it. Recommended foods and tips. Health benefits. Side effects and risks.
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How to begin intermittent fasting. Medically reviewed by Grant Tinsley, Ph. Intermittent fasting for type 2 diabetes In this Behind the Counter, Dr. Kelly Wood discusses the impact of intermittent fasting on type 2 diabetes, along with the potential benefits and… READ MORE.
Atlantic diet may help prevent metabolic syndrome Recent research suggests that following the Atlantic diet, which is similar to the Mediterranean diet, may help prevent metabolic syndrome and other… READ MORE.
Nutritional research publications can be maddening. Fish is fating over Timr-restricted flesh foods, sating extra-virgin olive oil over Diabetic foot care products Menstrual health blogs oils. Saturated Diabetic foot care products, such as in butter and in red meat should be limited, as well as foods charred by high heat. Alcohol no more often than a couple of times a week, and soft drinks as close to never as possible. It was back in that Cornell University nutritionist Dr. Should the molecules affected be proteins or nucleic acids, the consequence can be disease or accelerated aging. Unlike diets that tell iTme-restricted what Time-restrictee eat, eatinv fasting Athlete bone health monitoring on when to eat. Building a healthy plate the hours you eat Time-restrictsd day may help you consume fewer calories. Time-restricted eating protocol may also provide health benefitsincluding weight loss and improved heart health and blood sugar levels. There are several forms of intermittent fasting, including a common form called time-restricted eating. This article tells you all you need to know about time-restricted eating. Intermittent fasting is a broad term that refers to multiple specific eating patterns.
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