Decreasing oxidative stress oxldative increasing antioxidant defense has ane hypothesized strezs one mechanism by which caloric restriction CR increases longevity in animals. All eestriction was provided to participants for 6 mo. Caaloric significant change was observed in other plasma caloric restriction and oxidative stress such Restfiction superoxide dismutase oxjdative catalase.
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: Caloric restriction and oxidative stress| Access this article | Healthy weight distribution of brain stgess and neurodegenerative disorders oxixative genes, diet, BMI for Nutrition behavior. Oxiddative Restriction and Mitochondrial Oxidative Stress. Caloric restriction and oxidative stress EJAustad SN The evolution of the antiaging action of dietary restriction: a hypothesis. Mean SD exercise duration per session was 53 11 minutes in women and 45 14 minutes in men. Gov't Research Support, U. |
| Caloric Restriction and Mitochondrial Oxidative Stress | Ninkovic M ,. Vucevic D ,. Tomasevic T ,. Radosavljevic T. Affiliations 1. Institute of Pathophysiology, University of Belgrade, Belgrade, Serbia. Authors Stankovic M 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook. Abstract Moderate caloric restriction prolongs lifespan. Changes in oxidative stress and hormesis may be involved in this process. The aim of this study is to examine the effects of different levels of chronic caloric restriction CR and acute fasting on stress response and oxidative stress parameters in rat liver and plasma. To determine alanine aminotransferase ALT , aspartate aminotransferase AST and superoxide dismutase SOD activity, concentration of corticosterone, nitrites and nitrates NOx , malondialdehyde MDA and glutathione GSH , liver samples and blood were collected. Increase in plasma corticosterone concentration and AST and ALT activity was found in severe CR. Severe CR and acute fasting increase oxidative damage and decrease antioxidative capacity of hepatocytes. Moderate CR increases antioxidative capacity of hepatocytes due to increase in Mn-SOD activity and GSH concentration, which might have a role in anti-aging and hormetic mechanism of CR. Raji-Amirhasani A , Khaksari M , Soltani Z , Saberi S , Iranpour M , Darvishzadeh Mahani F , Hajializadeh Z , Sabet N BMC Nephrol , 24 1 , 20 Mar Cited by: 1 article PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license. Effects of Different Calorie Restriction Protocols on Oxidative Stress Parameters in a Transgenic Mouse Model of Breast Cancer. Cicekdal MB , Thomas PB , Guvenc Tuna B , Charehsaz M , Aydin A , Yilmaz B , Cleary MP , Dogan S Cureus , 14 8 :e, 11 Aug Cited by: 0 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license. The Effect of Fasting on Oxidative Stress in the Vital Organs of New Zealand White Rabbit. Hardiany NS , Karman AP , Calista ASP , Anindyanari BG , Rahardjo DE , Novira PR , Taufiq RR , Imtiyaz S , Antarianto RD Rep Biochem Mol Biol , 11 2 , 01 Jul Cited by: 3 articles PMID: PMCID: PMC Free full text in Europe PMC. Effects of caloric and time restriction diets on kidney health in rat model of postmenopausal acute kidney injury: An apoptosis and histopathological study. Darvishzadeh Mahani F , Khaksari M , Iranpour M , Soltani Z , Raji-Amirhasani A , Hajializadeh Z Iran J Basic Med Sci , 25 3 , 01 Mar Cited by: 2 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license. The Potential of Calorie Restriction and Calorie Restriction Mimetics in Delaying Aging: Focus on Experimental Models. Giacomello E , Toniolo L Nutrients , 13 7 , 09 Jul Cited by: 12 articles PMID: PMCID: PMC Review Articles in the Open Access Subset are available under a Creative Commons license. Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. The effects of caloric restriction against ethanol-induced oxidative and nitrosative cardiotoxicity and plasma lipids in rats. Vucevic D , Mladenovic D , Ninkovic M , Aleksic V , Stankovic MN , Stankovic M , Jorgacevic B , Vukicevic RJ , Radosavljevic T Exp Biol Med Maywood , 12 , 24 Oct Cited by: 6 articles PMID: Effect of 8. Gómez J , Caro P , Naudí A , Portero-Otin M , Pamplona R , Barja G Biogerontology , 8 5 , 08 May Cited by: 30 articles PMID: Acar A , Görenek L , Aydin A , Eyigün CP , Eken A , Sayal A , Pahsa A Mikrobiyol Bul , 43 3 , 01 Jul Cited by: 8 articles PMID: Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. Calabrese V , Cornelius C , Cuzzocrea S , Iavicoli I , Rizzarelli E , Calabrese EJ Mol Aspects Med , 32 , 01 Aug Cited by: articles PMID: Review. Minireview: the role of oxidative stress in relation to caloric restriction and longevity. Gredilla R , Barja G Endocrinology , 9 , 26 May Cited by: articles PMID: Review. Claim to ORCID Get citation. Follow us News blog Technical blog Twitter YouTube. About About Europe PMC. Become a funder. Tools Tools overview. ORCID article claiming. Journal list. Grant finder. External links service. Annotations submission service. Developers Developer resources. Articles RESTful API. Grants RESTful API. API case studies. SOAP web service. Annotations API. OAI service. Bulk downloads. Developers Forum. Help Help using Europe PMC. In summary, investigations performed during the last years in rodents clearly show that long-term reduction in caloric intake decreases the levels of oxidative damage to cellular macromolecules. Among them, mtDNA has been proposed to play an important role in the aging process, and various studies have shown that CR decreases both mitochondrial free radical generation and oxidative damage to mtDNA. The available studies suggest that the lessening of oxidative damage to mtDNA during CR is mainly due to decreases in the rate of generation of endogenous damage mitochondrial free radical generation , rather than to greater scavenging or repair of the damage already inflicted. Whether this reduction in mitochondrial free radical generation is hormonally controlled has not been clarified, and additional studies are needed. 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Neurobiol Aging 23 : — Sohal RS , Ku HH , Agarwal S , Forster MJ , Lal H Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev 74 : — Gredilla R , Barja G , López-Torres M Effect of short-term caloric restriction on H 2 O 2 production and oxidative DNA damage in rat liver mitochondria, and location of the free radical source. J Bioenerg Biomembr 33 : — Gredilla R , López-Torres M , Barja G Effect of time of restriction on the decrease in mitochondrial H2O2 production and oxidative DNA damage in the heart of food-restricted rats. Ramsey JJ , Hagopian K , Kenny TM , Koomson EK , Bevilacqua L , Weindruch R , Harper ME Proton leak and hydrogen peroxide production in liver mitochondria from energy-restricted rats. Am J Physiol : E31 — E Bevilacqua L , Ramsey JJ , Hagopian K , Weindruch R , Harper ME Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. Am J Physiol : E — E Gredilla R , Phaneuf S , Selman C , Kendaiah S , Leeuwenburgh C , Barja G Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Navbar Search Filter Endocrinology This issue Endocrine Society Journals Clinical Medicine Endocrinology and Diabetes Medicine and Health Books Journals Oxford Academic Mobile Enter search term Search. Endocrine Society Journals. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Caloric Restriction and Mitochondrial Oxidative Stress. Eating Less, Living Longer: Underlying Mechanisms. Hormonal Pathways and CR Effects. Journal Article. Minireview: The Role of Oxidative Stress in Relation to Caloric Restriction and Longevity. Ricardo Gredilla , Ricardo Gredilla. Oxford Academic. Gustavo Barja. Gustavo Barja, Departamento de Fisiología Animal II, Facultad de Biología, Universidad Complutense de Madrid, José Antonio Novais 2, Madrid , Spain. PDF Split View Views. Select Format Select format. ris Mendeley, Papers, Zotero. enw EndNote. bibtex BibTex. txt Medlars, RefWorks Download citation. Permissions Icon Permissions. Close Navbar Search Filter Endocrinology This issue Endocrine Society Journals Clinical Medicine Endocrinology and Diabetes Medicine and Health Books Journals Oxford Academic Enter search term Search. Abstract Reduction of caloric intake without malnutrition is one of the most consistent experimental interventions that increases mean and maximum life spans in different species. TABLE 1. Brain Heart Skeletal muscle Liver Open in new tab. TABLE 2. CR effect on Mt ROS generation. TABLE 3. First Published Online May 26, The effect of retarded growth upon the length of the life-span and ultimate body size. |
| Effects of caloric restriction on oxidative stress parameters. - Abstract - Europe PMC | Endocrinology , 9 , 26 May Carroll, MSPH; Lester R. First, our data provide evidence from a controlled trial design that the decrease in oxidative stress biomarkers induced by a modest caloric restriction is rapid. Results Baseline Characteristics and Compliance Thirty of 32 participants in the CR group and all controls completed the intervention part of the study i. Aksenova, M. |
| Publication types | Navbar Search Filter Endocrinology This issue Endocrine Society Journals Clinical Medicine Endocrinology and Diabetes Medicine and Health Books Journals Oxford Academic Mobile Enter search term Search. Wrote the paper: MSB JW SA LJR LW. Masoro EJ , Austad SN The evolution of the antiaging action of dietary restriction: a hypothesis. Redman LM, Ravussin E Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes. ris Mendeley, Papers, Zotero. Am J Physiol Endocrinol Metab. |
| Human Verification | Article CAS Google Scholar Rall, L. Competing interests: The authors have declared that no competing interests exist. Sanz A , Caro P , Gredilla R , Barja G Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at complex I and oxidative DNA damage in rat brain. Adherence to the protocol was monitored by urinary biomarkers sodium, potassium, nitrogen [22] , [23]. Gerwal, A. |
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