Forr As shown in Fig 10APDTC significantly decreased TNF-α mRNA levels Pycnogenol for inflammation by LPS. Pycnogenol is a standardised complex mixture of many molecules and has shown beneficial efficacy on blood circulation, strong anti-inflammatory and antioxidant effects and impressive action on the integrity of tissues.

Pycnogenol for inflammation -

In fact, this product is considered to be a potent free radical scavenger. Available as a dietary supplement, pycnogenol may enhance circulation, reduce inflammation and protect collagen against natural degradation. In Europe, it is used both orally as a dietary supplement and topically as part of anti-aging creams.

There is insufficient reliable information to conclude that pycnogenol is effective in any other indication, including topically. In , Canada adopted new regulations that control the manufacturing, packaging, labeling and importing of natural health products.

The new regulations also include an adverse reaction reporting system. Products that conform to the regulation's criteria are identified with a natural product number NPN and can be legally sold in Canada. This number indicates that the product meets specific criteria for safety and purity, not that it is effective for any indication.

Medicinal plant contents vary naturally from plant to plant - just as fruits from the same package may vary in taste and texture.

There is no standard to measure the active content of each plant. Thus, efficacy of natural products should be expected to vary from brand to brand as well as from bottle to bottle of the same brand.

For more information about the Natural Health Products Regulations, or to check if a product has been assessed, visit the Health Canada website at www. This content is for information purposes only and does not in any manner whatsoever replace the opinion or advice of your health care professional.

Always consult a health care professional before making a decision about your medication or treatment. Pycnogenol Pinus pinaster, pinus maritima, pine bark extract Efficacy Indications with possible efficacy : None Indications with possible, but poorly documented efficacy Asthma Chronic venous insufficiency High blood pressure Increase exercise capacity Retinopathies Other indications with no proof of efficacy : Allergies Cardiovascular protection Diabetic complications Inflammation Menstrual pain Peripheral circulatory problems To delay aging - as an antioxydant popular use Skin aging - topically popular use Security Risk of Drug Interactions : Low Adverse Effects : Rare Description Part of the plant used: french maritime pine bark Pinus pinaster, synonym Pinus maritima Pycnogenol contains bioflavonoids that are thought to have significant antioxidant activity.

Direction of use Chronic venous insufficiency : Pycnogenol seems to reduce leg pain and heaviness, and edema when used for 3 to 12 weeks.

Used doses: to mg 3 times daily. Lower dose of 45 to 90 mg daily seems to be effective. Taking Pycnogenol® almost entirely subdued COX-2, 5-LOX and FLAP induction in the immune cells of volunteers.

Control studies showed that Pycnogenol® did not have an effect on generation of the COX-1 enzyme, thus the potential for typical NSAID side effects is defied.

While Pycnogenol® is not a COXspecific inhibitor; it blocks the COX-2 enzyme production during inflammation only. There are COX-2 enzymes not involved in inflammation in other organs such as the kidneys, where it has important physiologic functions. Thus far, Pycnogenol® seems to be a unique tool for modulating inflammatory processes.

These pharmacologic findings are consistent with past clinical trials of Pycnogenol® that showed significantly lowered leukotriene levels in asthmatic patients, a condition originating from 5-LOX. Three recent clinical trials also showed pain relief and a reduced need for pain medication in arthritis patients after taking Pycnogenol®, results that are linked to COX-2 inhibition.

One arthritis study showed a significant reduction of inflammatory marker C-reactive protein. Pycnogenol® has been shown to inhibit inflammation in several dysmenorrhoea studies and also a reduction in skin inflammation related to sunburn and acne.

Pycnogenol® is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits.

The extract has been widely studied for the past 40 years and has more than published studies and review articles ensuring safety and efficacy as an ingredient. Today, Pycnogenol® is available in more than dietary supplements, multi-vitamins and health products worldwide.

For more information, visit www. Natural Health Science Inc. NHS , based in Hoboken, New Jersey, is the North American distributor for Pycnogenol® pic-noj-en-all brand French maritime pine bark extract on behalf of Horphag Research.

Pycnogenol® is a registered trademark of Horphag Research Ltd.

Pycnogenol® Fat burn tips Inflammation Disorders Injury prevention through personalized nutrition plans Moderating Immune System Response. GENEVA, Pycnpgenol - A Pycnpgenol published in Culinary expertise April Fat burn tips of the Journal of Inflammqtion shows the ability of pine foe extract Pycnogenol® Pycnogenol for inflammation to effectively inflmamation inflammation disorders in patients by moderating the Fat burn tips system response. Patients who supplemented with Pycnogenol demonstrated a modulated immune response which prevented non-infectious incidents from triggering full-fledged inflammation as the result of immune system reactions. Blood samples were taken prior to the start of the study and again after five days of supplementation with Pycjogenol. Key immune cells in the blood plasma, also known as monocytes, drawn after Pycnogenol supplementation showed a significantly lowered NF-ĸB response by 15 percent as compared to without supplementation of the pine bark extract. Inflammation is crucial for fighting infections and healing wounds. In monocytes, the triggering of NF-κB initiates generation of a fleet of pro-inflammatory molecules. Healthy microcirculation Pycnogenol for inflammation vital as it leads to Inflammagion well-functioning supply of nutrients and oxygen to all Pycnogneol of the body. In several previously published studies, Pycnogenol was shown to improve Lean muscle protein circulation in small fr vessels in the body, Pycnogenol for inflammation as the Pycnogenok fine microvessels in the skin, fingertips and in the inner ear or the retinal capillaries in the eye. Pycnogenol helps to break the cycle of inflammation and oxidative stress The anti-inflammatory and antioxidant properties of Pycnogenol further contribute to the versatile nature of the ingredient on body health and beauty. Inflammation and oxidative stress are closely linked processes in the body. Oxidative stress can trigger inflammation, which, in turn, can lead to more oxidative stress. However, too much inflammation can be chronic — the basis of various diseases such as atherosclerosis, arthritis or allergies.

Pycnogenol for inflammation -

Additionally, the abilities of Pycnogenol to increase the synthesis of collagen and to protect it from degradation are crucial for joint health collagen is an important component of articular cartilage.

In this way, the active ingredients of Pycnogenol can act directly where they are needed. This comprehensively explains how Pycnogenol contributes to restoring health in damaged joints. Pycnogenol French pine bark extract is one of the most widely investigated natural supplements worldwide with convincing data for various fields of application, including heart health, skincare, cognitive function and allergy control.

Pycnogenol is a standardised complex mixture of many molecules and has shown beneficial efficacy on blood circulation, strong anti-inflammatory and antioxidant effects and impressive action on the integrity of tissues.

References Zuo, et al. Cisar, et al. Jessberger, et al. Kohama, K. Herai and M. Maia, Jr, C. Haddad and J. Womens Health 6 , 35—39 Belcaro, et al.

Farid, et al. The SVOS San Valentino Osteo-Arthrosis Study. Mülek, et al. Citations 1—41 can be accessed in Part I of this article. X LinkedIn.

Companies: Horphag Research. You may also like Ingredients. According to the World Health Organization, men face a higher risk of premature death before reaching their 70th birthday compared with women.

The leading causes of mortality in men include cardiovascular diseases, cancer, diabetes and respiratory illnesses 1 , reports Dr Franziska Weichmann, Manager of Scientific Communications and Product Development at Horphag Research. Trending Articles The perfect pair: how vitamins K2 and D3 combine to support health and well-being Hydrogen and oxygen, Yin and Yang, Batman and Robin; the world is full of iconic duos that combine to become more than the sum of their parts.

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Dietary supplements. Mirtogenol is a groundbreaking solution for eye health; one of the first nutritional approaches to address issues related to the rise in intraocular pressure. Clinical studies show significant benefits for overall eye health. But how can one ingredient alone have such a wide range of benefits across multiple applications?

Peer-reviewed research adds to research in menopause and beauty, revealing new benefits for the celebrated super-antioxidant to address hair density. Now that the first of January festivities have finished, we realise that yet another year has passed. Wrinkles, loss of skin collagen and reduced skin elasticity are the first visible signs of ageing, which also reflect the internal ageing process too, writes Dr Franziska Weichmann, Manager of Scientific Communications and Product Development at Horphag Research.

This comes after a study in Bratislava found that Pycnogenol relieved hyperactivity and improved attention of children with ADHD. A recent study has shown that Pycnogenol may be effective at managing pediatric ADHD without side effects commonly associated with pharmaceuticals.

Pine bark extract is rich in plant pigments called bioflavonoids. Several laboratory studies have found that some of these bioflavonoids have anti-inflammatory and antioxidant properties. Antioxidants are substances that can override harmful molecules free radicals which are produced within your cells and which may cause tissue damage or disease.

Other studies have found that it can reduce the production of specific enzymes that break down cartilage. No major side-effects have been reported in previous trials, although minor side-effects include stomach upsets and headaches.

In theory, pine bark may lower blood pressure and blood sugar level, and these effects have also been reported in some RCTs. For that reason, you should be careful taking pine bark if you have hypertension or diabetes.

All participants were free to use NSAIDs throughout the three-month trial. In the second trial, people with mild osteoarthritis of the knee were randomly allocated to receive either mg Pycnogenol® or a placebo for three months. Osteoarthritis OA is the most common form of arthritis. It can cause joint pain and stiffness.

Learn about the causes, symptoms and treatments. Versus Arthritis About arthritis Complementary and alternative treatments Types of complementary treatments Pine bark extracts.

Pine bark extracts. Download complementary and alternative medicines report Download.

The gor of chronic diseases has increased ofr with Pycnogenoll rising trend of Pycnogenol and fertility lifestyles, reduced infla,mation activity, and dietary modifications in recent decades. Inflammation and oxidative stress Fat burn tips a Pydnogenol role in Pycnogenol for inflammation pathophysiology Pycnogwnol Pycnogenol for inflammation chronic diseases, such as type II diabetes, cardiovascular diseases, and hepatic conditions. Therefore, reducing inflammation and oxidative stress may be beneficial in the prevention and treatment of various chronic disorders. Since chronic diseases are not completely curable, various methods have been proposed for their control. Complementary therapies and the use of natural antioxidant and antiinflammatory compounds are among these novel approaches. Pycnogenol PYC is a natural compound that could control inflammation and oxidative stress.