Facebook Visferal LinkedIn. Multiple pathogenic pathways Visceral fat and aging defective adipogenesis, inflammation, aberrant Recovery coaching services production, and insulin aaging, leading to adipose tissue dysfunction. Hepatic DNL fatty acid and triglyceride synthesis is increased in patients with nonalcoholic fatty liver disease NAFLD [ 36 ]. Dermal adipocyte lipolysis and myofibroblast conversion are required for efficient skin repair.

Visceral fat and aging -

Rather than focus on a single reading or absolute cut-off, keep an eye on whether your waist is growing are your pants getting snug at the waist? That should give you a good idea of whether you're gaining unhealthy visceral fat. Visceral fat can be measured in a variety of ways.

CT scans and full-body MRIs are the most precise, but they are expensive and rarely available, so investigators often use estimates based on waist circumference or waist size in proportion to height see "Gut check".

To ensure that they're not just measuring overall obesity, researchers also check whether a person's waist circumference is higher than average for her or his body mass index BMI.

Cardiovascular disease. Several studies have documented this effect. For example, a large study of European women ages 45 to 79 concluded that those with the biggest waists and those with the largest waists in relation to their hip size had more than double the risk of developing heart disease.

The risk was still nearly double even after adjustment for several other risk factors, including blood pressure, cholesterol, smoking, and BMI. Higher visceral-fat volume also has a deleterious impact on several other heart disease risk factors.

It's associated with higher blood pressure, blood sugar levels and triglyceride levels, and lower levels of HDL good cholesterol. Taken together, these changes, known as metabolic syndrome, create a serious risk for cardiovascular disease and type 2 diabetes. Researchers at Kaiser Permanente found that people in their early 40s with the highest levels of abdominal fat, compared with those who had the least abdominal fat at that age, were nearly three times more likely to develop dementia including Alzheimer's disease by their mids to early 80s.

Dementia was not associated with increased thigh size. The risks were highest for women who were both large-waisted and overweight or obese. The investigators believe that belly fat raises the risk of asthma more than other poundage because it has inflammatory effects throughout the body, including in the airways.

Breast cancer. A combined analysis of several studies found that premenopausal women with abdominal obesity the largest waist size in proportion to their height were at greater risk for breast cancer. Large waists were also linked to breast cancer risk among postmenopausal women, but that effect was not significant once BMI was taken into account.

Colorectal cancer. People with the most visceral fat have three times the risk of developing colorectal adenomas precancerous polyps than those with the least visceral fat.

The relationship was found after many other risks were accounted for. The researchers also confirmed that adenomatous polyps in the colon are associated with insulin resistance, which may be the mechanism that increases the cancer risk.

Where you tend to gain fat depends on your genes, your hormones, your age, your birth weight smaller babies more readily add belly fat later in life , and whether you've had children women who have given birth tend to develop more visceral fat than women who haven't.

As young adults, women on average have less visceral fat than men, but that changes with menopause. You can't change your birth weight or your genes, and you can't hold off menopause.

But there are several ways you can minimize the accumulation of visceral fat. The good news is that because it's more readily metabolized into fatty acids, it responds more efficiently to diet and exercise than fat on the hips and thighs.

Here are some approaches that may help:. Keep moving. Exercise can help reduce your waist circumference. Even if you don't lose weight, you lose visceral belly fat and gain muscle mass. Engage in at least 30 minutes of moderate-intensity activity most days, such as brisk walking or bicycling at a casual pace.

Also create opportunities to add motion to routine tasks. For example, park farther from your destination and walk the rest of the way, take the stairs instead of the elevator, and stand while you talk on the phone.

Studies have shown that you can help trim visceral fat or prevent its growth with both aerobic activity such as brisk walking and strength training exercising with weights.

Spot exercises, such as sit-ups, can tighten abdominal muscles but won't get at visceral fat. Exercise can also help keep fat from coming back.

Eat right. Choose a balanced diet that helps you achieve and maintain a healthy weight. Avoid products that seem to encourage belly fat deposition, especially simple sugars like fructose-sweetened foods and beverages.

Don't smoke. The more you smoke, the more likely you are to store fat in your abdomen rather than on your hips and thighs.

Shown are results for young 2-month-old and old month-old F1 hybrids of F and Brown Norway rats. Hepatic insulin sensitivity in aging rats. The ability of insulin to suppress EGP was studied using glucose tracer methodology see research design and methods.

R a , rate of EGP. Development of diabetes and the regrowth of VF in ZDF rats. Six rats from each group were studied using a pancreatic clamp, and the rest were monitored for 4 months until they developed diabetes. Gene expression of TNF-α and leptin. RT and real-time PCR analysis for TNF-α, leptin, and β-actin are described in research design and methods.

B : Analysis of all real-time PCR data obtained in all rats, corrected for intensity of β-actin and presented in arbitrary units. mesenteric fat. Gene expression of resistin A and ACRP30 B. B : Real-time PCR data obtained from all rats corrected for the intensity of β-actin and presented in arbitrary units.

M and SC. young 2-month-old , and old month-old F1 hybrids of F and Brown Norway rats were used in these experiments. The table depicts the amounts of VF or SC removed at the surgery, body weight, lean body mass, non-VF fat mass, total VF, and epididymal, perinephric, and mesenteric fat, which were determined at killing after the experiments.

Plasma glucose, insulin, FFA concentrations, basal rate of EGP R a , glucose infusion rate GIR , glycolysis Gly , and glycogen synthesis GS during the basal period and during the pancreatic euglycemic clamp are shown.

These parameters were measured at basal conditions and during the insulin clamps see group description in research design and methods. The table depicts the amounts of VF removed at surgery, body weight, lean body mass, non-VF fat mass, and total VF, epididymal, perinephric, and mesenteric fat that were detected after the study.

This work was supported by grants from the National Institutes of Health Paul Beeson Physician Faculty Scholar in Aging Award and RO1-AG to N. and RDK and ROI-DK to L. Address correspondence and reprint requests to Nir Barzilai, Institute for Aging Research, Belfer Bldg.

E-mail: barzilai aecom. CR, caloric restriction; dsDNA, double-stranded DNA; EGP, endogenous glucose production; FFA, free fatty acid; SC, subcutaneous; TNF-α, tumor necrosis factor-α; VF, visceral fat. Sign In or Create an Account. Search Dropdown Menu. header search search input Search input auto suggest.

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RESEARCH DESIGN AND METHODS. Article Information. Article Navigation. Obesity Studies October 01 Removal of Visceral Fat Prevents Insulin Resistance and Glucose Intolerance of Aging : An Adipokine-Mediated Process?

Ilan Gabriely ; Ilan Gabriely. This Site. Google Scholar. Xiao Hui Ma ; Xiao Hui Ma. Xiao Man Yang ; Xiao Man Yang. Gil Atzmon ; Gil Atzmon. Michael W. Rajala ; Michael W. Anders H. Berg ; Anders H. Phillip Scherer ; Phillip Scherer.

Luciano Rossetti ; Luciano Rossetti. Nir Barzilai Nir Barzilai. Diabetes ;51 10 — Get Permissions. toolbar search Search Dropdown Menu.

toolbar search search input Search input auto suggest. View large Download slide. TABLE 1 Body composition and fat distribution of aging rats. young and CR;. All data are presented as means ± SE. View Large. TABLE 2 Metabolic characteristics of aging rats.

TABLE 3 Body composition and fat distribution of ZDF rats. TABLE 4 Metabolic characteristics of ZDF rats. Cefalu WT, Wang ZQ, Werbel S, Bell-Farrow A, Crouse JR 3rd, Hinson WH, Terry JG, Anderson R: Contribution of visceral fat mass to the insulin resistance of aging.

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