Free radicals and DNA damage -
Compounds called antioxidants act as free radical scavengers by initiating reactions that make free radicals non-toxic to cells. Evidence indicates that damage by free radicals is a contributing factor to the pathology of HD.
Consequently, compounds with antioxidant properties are being studied to see if they can serve as possible treatments for HD. Free radicals are atoms or molecules that are highly reactive with other cellular structures because they contain unpaired electrons.
Free radicals are natural by-products of ongoing biochemical reactions in the body, including ordinary metabolic processes and immune system responses.
Free radical-generating substances can be found in the food we eat, the drugs and medicines we take, the air we breathe, and the water we drink. These substances include fried foods, alcohol, tobacco smoke, pesticides, air pollutants, and many more. Such a mechanism enables G-quadruplex-forming sequences to act as long-range sensors of oxidative stress, impacting gene expression via the DNA repair mechanism that reads and ultimately erases the oxidized base.
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Learn about institutional subscriptions. Table of contents 13 chapters Search within book Search. Front Matter Pages I-XX. Introduction Pages Formation of Reactive Free Radicals in an Aqueous Environment Pages The Hydroxyl Radical Pages Hydrogen Atom and Hydrated Electron Pages Inorganic Radicals Pages Carbon-Centered Radicals Pages Heteroatom-Centered Radicals Pages Peroxyl Radicals Pages Polymer Radicals Pages Nucleobases, Nucleosides and Nucleotides Pages Polynucleotides and Single-Stranded DNA Fragments Pages DNA and Double-Stranded Oligonucleotides Pages Methods Pages Back Matter Pages Back to top.
About this book The free-radical chemistry of DNA had been discussed in some detail in in my book The Chemical Basis of Radiation Biology.
The free radical theory of aging, Raficals of the Energy project financing suggested Free radicals and DNA damage of aging Radicqls et al. This theory has evolved over time to emphasize the radcals of damaeg radical induced mitochondrial DNA mtDNA radocals and the accumulation danage mtDNA rdicals Miquel et al. Given Wearable glucose monitor proximity of mtDNA to the electron transport chain, a primary producer of free radicals, it postulates that the mutations would promote mitochondrial dysfunction and concomitantly increase free radical production in a positive feedback loop. The observation of oxidative damage in the form of 7,8-dihydrooxo-deoxyguanosine 8-oxodG DNA oxidative lesions accumulating with age has been a cornerstone of the free radical theory of aging Fraga et al. A major assumption of the free radical theory of aging is that random de novo or somatic mtDNA mutations gradually accumulate over time, eventually reaching pathological levels Harman, , Official Frree use. dmage A. gov wnd belongs to Wearable glucose monitor official government organization in the United States. gov website. Share sensitive information only on official, secure websites. Author s M Miral DizdarPawel Jaruga. Abstract Endogenous and exogenous sources cause free radical-induced DNA damage in living organisms by a variety of mechanisms.
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