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Bone Strength. Detoxing, Metabolism Improvement, Digestive Health. Other ingredients: Microcrystalline cellulose, coating, stearic acid, croscarmellose sodium and vegetable stearate. Calcium, Calcium D-Glucarate. Other Ingredients: Gelatin Capsule, Rice Powder, Vegetable Magnesium Stearate, Silica.

Calcium from Calcium Carbonate , Microcrystalline Cellulose, Croscarmellose Sodium, Acacia Gum, Malto-Dextrin, Magnesium Stearate, Silica, Hydroxypropyl Methylcellulose, Triacetin, Polydextrose. Other Ingredients: Hypromellose derived from cellulose capsule, Medium Chain Triglyceride Oil.

Calcium D Glucarate resulting in 62mg of Calcium mg and BioPerine® 2. Brief content visible, double tap to read full content. Full content visible, double tap to read brief content. Help others learn more about this product by uploading a video! Important information Safety Information Allergy warning: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

Ingredients One Capsule Contains: Calcium 62 mg. Directions Take 1 capsule three times daily or as recommended by a health-care practitioner. Looking for specific info? Customer reviews. How customer reviews and ratings work Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.

Learn more how customers reviews work on Amazon. Images in this review. Reviews with images. See all photos. All photos. Gave me scary palpitations and high blood pressure! My heart went up to bpm while I was in bed!

Very fast palpitations and much higher than normal blood pressure. It just happened again tonight. My heart rate jumped to bpm out of no where and earlier I felt like I was going to pass out while cooking dinner and my blood pressure was through the roof!!

I took an aspirin in case! More Hide. Thank you for your feedback. Sorry, there was an error. Sorry we couldn't load the review. Sort reviews by Top reviews Most recent Top reviews.

Top reviews from the United States. There was a problem filtering reviews right now. Please try again later. Verified Purchase. Been on this for awhile and haven't noticed any benefits.

We're all different but I think it was just a mediocre purchase. One person found this helpful. No Rx needed. I've been taking this supplement for the past 3 months. They have made a HUGE difference in my skin. It use to take me 30 min just to cover up my acne with makeup in the mornings, but now I'm finished in less than 10 minutes - or can even go without makeup now!

If you are suffering from adult PMS acne, go on YouTube and watch "The 7 Different Types Of Acne by Amanda Ridout". She and pharmacist Ben Fuchs talk about specific supplements for each type of acne. I followed Ben's exact instruction on the "Premenstrual Acne" video.

I know it sounds like a lot of supplements, but I suffered with premenstrul acne for 3 years after I stopped taking birth control and taking these supplements every day is a piece of cake compared to dealing with the emotional drama of facing acne in the mirror every morning.

My skin was simply crying out for nutrients so it could heal itself and it took me 3 long years to finally figure it out. But now I appreciate every morning when I look in the mirror with clear skin! It is amazing what simple vitamins and minerals can do.

I've been struggling with estrogen dominance for a few years now. I've been on a pretty strict hormone-balancing diet and I avoid environmental estrogens as much as I can, but I've still struggled with the side effects - insomnia, night sweats, mood swings, etc I read about calcium d-glucarate, so I decided to give it a try.

I've been taking it for almost a month now and I can report that it works! I'm finally able to sleep through the night, and I feel more normal than I have in years.

I did experience some mild headaches at certain points in my cycle, but I read that this is normal and it is a sign that your body is detoxing. I recommend anyone who knows they are estrogen dominant to take this supplement.

I have been taking Thorne's calcium d-glucarate for 3 years now with the exception of a 6 mo period when I was overseas and could not get it , it has been a huge help with reducing my symptoms from PMDD. Paired with a clean diet i. I currently take it 2x a day along with Thorne's DIM with great success.

This supplement took a couple months of consistent usage before I experienced the most benefit. I do not experience any noticeable side effects from it. It is expensive comparatively but is absolutely worth the money to not experience PMDD hell week every month.

Didnt realize it also helps with Estrogen Dominance.. bonus benefit. Using it for salicylate intolerance and it has made a huge difference.

ND suggested it and considering the cost give it a skeptical try. After 2 weeks feeling much better. IBS gone and gas is way down. Not going to chug a pint of Almond milk and take some ibruprofen just yet but getting much better.

good luck. I had lab work done which showed I was estrogen dominant due to an overgrowth of Candida. My Dr recommended this supplement to help metabolize and detox the excessive estrogen.

The pills arrived on the first day of my menstrual cycle and worked instantly! No more bed ridden cramps or pain!!! To me, this was much more effective than Liposomal Glutathione. No kidding. I have CFS, heavy metal toxicity, IBS, and pretty much all sorts of health problems with me and this supplement helped me get better tremendously.

I have given this supplement to my parents who also have benefited from taking it. One area of significant concern is drug interactions between over the counter or prescription drugs and supplements potentially harming you in unexpected ways. This can be a problem with common and otherwise potentially harmless supplements such as St.

Failing to tell your healthcare provider that you are taking St. These potential adverse events can arise from a wide range of sources including dietary supplements, probiotics, multivitamins, and herbal products. Though it might be tempting to think these reactions would only arise from exotic or uncommon substances, it is possible that common and well-known supplements can cause serious liver damage if paired with the wrong medication.

Your body has the ability to process certain amounts of many kinds of vitamins and minerals. This is the reason the FDA regulates levels of recommended daily intake of nutrients such as vitamin D, folic acid, or calcium. If levels of these or many other nutrients exceed levels your body can metabolize, waste products will begin piling up in the liver, leading to potential health risks.

If you are taking dietary supplements, especially for weight loss or building muscle, it is important to know the signs of potential liver damage. Some of the most common symptoms are listed below:. Liver damage or liver failure caused by taking supplements could come from many sources, though there are certain types of dietary supplements that are increasingly coming under scrutiny.

Supplements used in bodybuilding or weight loss can be particularly hard on the liver, as they attempt to alter metabolic processes in which your liver plays a role. While organizations like the FDA can be relied on for information about prescription drugs, supplements and herbal remedies are not regulated in the same way.

This means that supplement manufacturers have much greater leeway in manufacturing and labeling supplements. As a result, it is not always possible for consumers to know about potential risks for liver damage just by reading supplement labels.

Nearly anything can become damaging if you consume too much of it, but certain vitamins and minerals have a greater chance of causing liver damage than others. The National Institutes of Health NIH runs the Office of Dietary Supplements, which lists Vitamin C, folate, and calcium as just a few examples of nutrients that are commonly thought of as healthy that can be very damaging to the liver if consumed in excessive quantities.

The list of medications that could potentially lead to negative drug interactions is long, and includes some of the most common classes of drugs used to treat health problems like heart disease, high blood pressure, and high cholesterol.

Even antidepressants can sometimes lead to unexpected outcomes when paired with the wrong supplements.

It is difficult to accurately diagnose liver problems, as there are many different health conditions that could result in similar symptoms and damage to liver tissue. Acute liver failure is a deadly condition that can quickly result in death if left untreated.

However, Aquamin, which is rich in calcium, magnesium and additional elements derived from calcified red algae , could help stop this progression. view more. Philadelphia April 3, — Results from a preclinical study add new evidence that a multi-mineral dietary supplement known as Aquamin could be a simple and effective way to reduce the long-term health consequences of non-alcoholic fatty liver disease.

Aquamin, which is derived from calcified red marine algae, is rich in calcium, magnesium and 72 other minerals and trace elements. S are affected by non-alcoholic fatty liver disease, which is characterized by an excess of fat stored in the liver.

Some people with this disease develop a more aggressive form known as non-alcoholic steatohepatitis NASH in which the liver is inflamed.

This can progress to fibrosis, advanced scarring known as cirrhosis, liver failure and cancer. In preliminary studies, the researchers fed mice a high-fat diet to induce the development of non-alcoholic fatty liver disease and NASH.

They studied these mice for 15 to 18 months to observe the full spectrum of liver disease, including advanced fibrotic changes and liver cancer. In short-term studies lasting about 24 weeks, the researchers identified protein changes associated with the NASH and reduced tumor formation in the longer studies.

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Allergy warning: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. This product also does not contain lactose, palmitic acid, or magnesium, calcium, or vegetable stearates.

Pregnancy warning: If pregnant, consult your health-care practitioner before using this product. One Capsule Contains: Calcium 62 mg. Calcium D-Glucarate mg. Other Ingredients: Hypromellose derived from cellulose capsule, Silicon Dioxide.

These products are not intended to diagnose, treat, cure or prevent any disease. Please contact your healthcare professional immediately if you experience any unwanted side effects.

The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

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Climate Pledge Friendly. Purchase options and add-ons. Brand THORNE Item Form capsules Primary Supplement Type Calcium Unit Count About this item Supports glucuronidation, an important liver health pathway To prevent recycling of environmental toxins and hormones back into the liver, aiding in their elimination from the body Supports healthy hormone metabolism Thorne products contain ingredients from the purest sources worldwide.

Flavors, colors, preservatives, and sweeteners are derived from natural sources. Our products never contain gluten, Genetically Modified Organisms known as GMOs , artificial preservatives, stearates, wheat, rye, barley, eggs, or nuts. This product does not contain dairy, soy, corn, sugar, or magnesium stearate Thorne's commitment to integrity and science-backed products has helped us earn the trust of thousands of health-care professionals, U.

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Add all 3 to Cart. Some of these items ship sooner than the others. Show details Hide details. Choose items to buy together. Similar items that may ship from close to you. Page 1 of 1 Start over Page 1 of 1. The National Institutes of Health NIH runs the Office of Dietary Supplements, which lists Vitamin C, folate, and calcium as just a few examples of nutrients that are commonly thought of as healthy that can be very damaging to the liver if consumed in excessive quantities.

The list of medications that could potentially lead to negative drug interactions is long, and includes some of the most common classes of drugs used to treat health problems like heart disease, high blood pressure, and high cholesterol.

Even antidepressants can sometimes lead to unexpected outcomes when paired with the wrong supplements. It is difficult to accurately diagnose liver problems, as there are many different health conditions that could result in similar symptoms and damage to liver tissue.

Acute liver failure is a deadly condition that can quickly result in death if left untreated. If you have reason to believe that you may be suffering from sudden severe liver damage or failure, you should seek medical treatment immediately. When you receive care, be as clear and thorough as possible in explaining to your doctor all medications and supplements you are currently taking.

As is the case with nearly everything related to your health, taking a careful, measured approach, and consulting with your healthcare provider, is likely safer than trusting in the bold claims of any particular dietary supplement.

This is particularly true when it comes to weight loss or bodybuilding supplements or sexual enhancement pills that claim to provide dramatic results not available by any other means. Products that claim to radically alter your metabolism or add significant amounts of muscle can be very dangerous for your overall health, and for your liver in particular.

The increasing number of young men seeking medical care for symptoms of liver damage despite being otherwise healthy is placing increasing scrutiny on supplements that claim to burn fat or build muscle at dramatic rates. Your digestive tract is a complex system of many organs working together, and while the human body can adapt to a remarkable number of stresses and toxins, damaging any part of your digestive system can lead to serious and potentially life-long consequences for your overall health.

At Cary Gastroenterology, we know that caring for your entire digestive system is crucial for good health. Especially as we age, careful attention to what we eat and drink, and what other vitamins and minerals we take in through supplements and multivitamins is increasingly important.

If you are concerned that supplements you have been taking might lead to liver damage, or just want to learn more about how to take steps toward better digestive health, request an appointment at Cary Gastroenterology today. Book an appointment today at one of our office locations throughout the Cary, Raleigh, Holly Springs and Triangle region.

We are committed to providing you with the most comprehensive quality of gastroenterology care. Home Blog Too Much of a Good Thing: The Dangers of Supplements.

Do Dietary Supplements Damage Your Liver? Can Supplements Affect Liver Enzymes? The Hidden Dangers of Dietary Supplements One area of significant concern is drug interactions between over the counter or prescription drugs and supplements potentially harming you in unexpected ways.

PLoS ONE. Ryu O-H, Chung W, Lee S, Hong K-S, Choi M-G, Yoo HJ The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes. Korean J Intern Med — Alkharfy KM, Al-Daghri NM, Yakout SM, Hussain T, Mohammed AK, Krishnaswamy S Influence of vitamin D treatment on transcriptional regulation of insulin-sensitive genes.

Metab Syndr Relat Disord — Geldenhuys S, Hart PH, Endersby R, Jacoby P, Feelisch M, Weller RB, Matthews V, Gorman S Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet.

Diabetes — Brink EJ, Beynen AC, Dekker PR, Van Beresteijn E, van der Meer R Interaction of calcium and phosphate decreases ileal magnesium solubility and apparent magnesium absorption in rats. Hruby A, Ngwa JS, Renström F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF, Kanoni S, Lehtimäki T Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies.

Nutr — Jeddi S, Syedmoradi L, Bagheripour F, Ghasemi A The effects of vitamin D on insulin release from isolated islets of rats. Int J Endocrinol Metab. Peterson JM, Seldin MM, Wei Z, Aja S, Wong GW CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism.

Am J Physiol Gastrointest Liver Physiol G—G Mol Cell Biochem — Li X, Jiang L, Yang M, Y-w Wu, S-x Sun, J-z Sun Expression of CTRP3, a novel adipokine, in rats at different pathogenic stages of type 2 diabetes mellitus and the impacts of GLP-1 receptor agonist on it. J Diabetes Res.

Eliades M, Spyrou E, Agrawal N, Lazo M, Brancati F, Potter J, Koteish A, Clark J, Guallar E, Hernaez R Meta-analysis: vitamin D and non-alcoholic fatty liver disease. Aliment Pharmacol Ther — Targher G, Bertolini L, Scala L, Cigolini M, Zenari L, Falezza G, Arcaro G Associations between serum hydroxyvitamin D 3 concentrations and liver histology in patients with non-alcoholic fatty liver disease.

Black LJ, Jacoby P, She Ping-Delfos WC, Mori TA, Beilin LJ, Olynyk JK, Ayonrinde OT, Huang RC, Holt PG, Hart PH, Oddy WH, Adams LA Low serum hydroxyvitamin D concentrations are associated with non-alcoholic fatty liver disease in adolescents independent of adiposity. J Gastroenterol Hepatol — Bril F, Maximos M, Portillo-Sanchez P, Biernacki D, Lomonaco R, Subbarayan S, Correa M, Lo M, Suman A, Cusi K Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis.

J Hepatol — Li L, Zhang L, Pan S, Wu X, Yin X No significant association between vitamin D and nonalcoholic fatty liver disease in a Chinese population. Dig Dis Sci — Roth CL, Elfers CT, Figlewicz DP, Melhorn SJ, Morton GJ, Hoofnagle A, Yeh MM, Nelson JE, Kowdley KV Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and toll-like receptor activation.

Kong M, Zhu L, Bai L, Zhang X, Chen Y, Liu S, Zheng S, Pandol SJ, Han Y-P, Duan Z Vitamin D deficiency promotes nonalcoholic steatohepatitis through impaired enterohepatic circulation in animal model.

Marotte C, Weisstaub A, Bryk G, Olguin MC, Posadas M, Lucero D, Schreier L, De Portela MLPM, Zeni SN Effect of dietary calcium Ca on body composition and Ca metabolism during growth in genetically obese β male rats. Eur J Nutr — Bhat M, Noolu B, Qadri SS, Ismail A Vitamin D deficiency decreases adiposity in rats and causes altered expression of uncoupling proteins and steroid receptor coactivator3.

J Steroid Biochem Mol Biol — Winder W, Hardie D AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol Endocrinol Metab E1—E Steinberg GR, Kemp BE AMPK in health and disease.

Physiol Rev — Guo T, Woo S-L, Guo X, Li H, Zheng J, Botchlett R, Liu M, Pei Y, Xu H, Cai Y Berberine ameliorates hepatic steatosis and suppresses liver and adipose tissue inflammation in mice with diet-induced obesity.

Sci Rep. Muse ED, Obici S, Bhanot S, Monia BP, McKay RA, Rajala MW, Scherer PE, Rossetti L Role of resistin in diet-induced hepatic insulin resistance. Matsumoto M, Hagio M, Inoue R, Mitani T, Yajima M, Hara H, Yajima T Long-term oral feeding of lutein-fortified milk increases voluntary running distance in rats.

Download references. The authors would like to express their gratitude toward Dr. Amir Abbas Farshid and Dr. Ali Asghar Tehrani for conducting the pathological assessments. The authors would also like to thank the Pharma chemie and Daana Pharmaceutical Companies and Beyza 21 Feed Mill Company.

Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Cellular and Molecular Research Center, Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

Department of Nutrition, Food and Beverages Safety Research Center, Faculty of Medicine, Urmia University of Medical Sciences, PO Box: , Urmia, Iran. You can also search for this author in PubMed Google Scholar.

Correspondence to Mohammad Alizadeh. All animal protocols were approved by the Ethics Committee of Urmia Medical Sciences University ir. Reprints and permissions.

Shojaei Zarghani, S. Calcium and vitamin D 3 combinations improve fatty liver disease through AMPK-independent mechanisms. Eur J Nutr 57 , — Download citation. Received : 15 August Accepted : 06 December Published : 17 December Issue Date : March Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Purpose Some research findings suggest that calcium plus vitamin D VitD might have a preventive effect on nonalcoholic fatty liver disease development.

Methods Thirty male Wistar rats were fed with normal or HFHFr diet containing low calcium 0. Results Rats fed on high calcium plus VitD 3 diets, especially VHCD, demonstrated lower adiposity, serum liver enzymes, hepatic lipid accumulation and steatosis.

Conclusions The results showed high calcium plus VitD 3 intakes considerably prevent biochemical and hepatic changes induced by HFHFr diet, probably via an insulin and AMPK-independent pathway.

Access this article Log in via an institution. References Lazo M, Clark JM The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis — Article Google Scholar Fabbrini E, Sullivan S, Klein S Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications.

Hepatology — Article CAS Google Scholar Keast DR, Gallant KMH, Albertson AM, Gugger CK, Holschuh NM Associations between yogurt, dairy, calcium, and vitamin D intake and obesity among us children aged 8—18 years: NHANES, — For someone at risk for hemochromatosis, such as those with a genetic predisposition, the effect of calcium on iron absorption may be beneficial to the liver.

The liver produces the major plasma protein in the blood known as albumin. Albumin binds to water and cations, like calcium, to regulate the osmotic pressure in the blood. A diseased liver cannot produce enough albumin, which affects the pressure within the vascular system and allows fluid to leak out of the blood vessels.

In addition, when albumin levels fall, less calcium can remain in the bloodstream, leading to a condition known as hypocalcemia.

Hypocalcemia occurs when the amount of calcium in the blood drops below 8. It's most commonly caused by a malfunction in the parathyroid gland, which produces parathyroid hormone essential to regulating blood calcium levels.

Hypocalcemia produces symptoms ranging from mild repetitive tremors known as tetany to serious conditions like seizures, dementia, low blood pressure and congestive heart failure. To avoid low blood calcium levels caused by liver disease, it is important you maintain a healthy liver.

Approximately 75 percent of the blood entering the liver flows through the portal vein carrying the blood from the small intestine, stomach, pancreas and spleen, according to Colorado State University. Although this blood contains all the nutrients just absorbed through the small intestine, it also contains all the toxins you ingested.

Moreover, in another study, subjects with NAFLD or alcoholic fatty liver were at higher risk of developing magnesium deficiency [ 39 ]. However, another study conducted in Canada was not able to find any links between magnesium intake and risk of NAFLD; considering the structural weaknesses in this study, the results might lack enough credibility to be deductible [ 40 ].

As mentioned beforehand in the present article, calcium has some biochemical interactions with magnesium. These interactions might have clinical manifestations concerning the pathogenesis of several metabolic disorders. Wenshuai Li et al. Their findings suggested that beneficial effect of magnesium might be attenuated when calcium intake is higher than the amount recommended by Dietary Reference Intakes DRIs.

One of the important mechanisms might be the suppressive effects of high calcium intake on the gastrointestinal absorption and renal reabsorption of magnesium which may alter the excretion of the ion in the feces and urine [ 24 , 42 ].

As evident by the results of the present study, the Ca:Mg intake ratio might be a useful indicator to observe the combined impact of these two major minerals may exert upon different physiologic, as well as pathologic pathways.

USDA food surveys from to show a rising food Ca:Mg ratio from 2. Furthermore, there is growing evidence indicating that modifications in serum Ca:Mg ratio is associated with some disorders including diabetes and metabolic syndrome [ 44 ], breast cancer [ 45 , 46 ], cardiovascular diseases [ 47 ], and higher mortality [ 29 ].

Even though the optimal calcium to magnesium intake ratio is yet to be specified, some studies have suggested a ratio as the optimum ratio [ 47 ]. Consistent with previous studies, our study indicated that participants in the third and fourth quartiles of Ca:Mg intake ratio ranging from 2.

The regulation of calcium and magnesium homeostasis in the body is interdependent. Calcium-sensitive receptor, also known as CaSR, is responsible to monitor plasma levels of both cations [ 48 ].

Whenever the plasma level of each of the cations drops, CaSR up regulates the related mechanisms leading to an increase in its blood level, regardless of the other cation concentration in the blood [ 49 , 50 ].

Furthermore, a drop in serum Mg could also decrease intracellular levels of Mg reducing the cellular Mg—ATP deposits.

This may lead to an increase in Ca influx, which, in turn, may upgrade the Ca—ATP level of the cell. Increased intracellular calcium levels have been proposed an underlying mechanism for the pathogenesis of several metabolic and inflammatory disorders such as obesity, metabolic syndrome, diabetes, and NAFLD [ 45 , 51 , 52 , 53 ].

This is the first observational study that evaluated the relationship between Ca:Mg intake ratio and the development of NAFLD. We were able to conduct the present research on a statistically acceptable sample size of subjects with corresponding socio-economic status.

The present study also has some limitations. Case-control studies may prove an association but they do not demonstrate causation.

Proving the causal relationship requires future intervention studies. Although we used a validated FFQ for measurement of dietary intakes, recall bias and measurement error are inevitable errors.

Furthermore, although we tried to control the effect of major confounding factors, the effects of unknown factors and residual confounding cannot be ruled out.

We also suggest that liver stiffness measurement LSM by Fibroscan be used in future studies for accurate prediction of liver fibrosis severity. Calculation of Fibrosis-4 FIB-4 or NAFLD fibrosis score NFS which are indicators of advanced fibrosis in NAFLD patients used in exclusion of advanced fibrosis owing to its high negative predictive value is also recommended [ 54 , 55 , 56 ].

The current study revealed that higher dietary calcium to magnesium intake ratio is associated with a greater development of NAFLD.

Further interventional studies are needed to confirm the causal relationship between the dietary calcium to magnesium intake ratio and incidental NAFLD.

Chalasani N, Younossi Z: The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.

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International urology and nephrology , — Quamme GA: Recent developments in intestinal magnesium absorption. Current opinion in gastroenterology , — Guerrero-Romero F, Rodriguez-Moran M: Low serum magnesium levels and metabolic syndrome.

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