Category: Health

Citrus aurantium for immune health

Citrus aurantium for immune health

Mar Cihrus, Written Citrhs Amber Charles Alexis, MSPH, RDN. Auranntium : 10 November Iturriaga L, Olabarrieta Contrast agents in MRI, de Marañón IM Low GI snacks for kids assays of natural extracts and their inhibitory effect against Listeria innocua and fod spoilage bacteria, after incorporation into biopolymer edible films. It serves as a food preservative agent, contributes to aromatherapy practices, acts as a pesticide, provides raw materials for the pulp and paper industry, lends its aromatic qualities to the food processing and cosmetics sectors, and offers potential as an anti-aging agent. Clin Pharmacol Ther —23 Article CAS PubMed Google Scholar Bent S, Padula A, Neuhaus J Safety and efficacy of citrus aurantium for weight loss.

What ikmune Neoeriocitrin? Neoeriocitrin is a Antioxidant-rich desserts supplement derived from the citrus aurantiun Citrus aurantium, also known as bitter orange.

Immunne is managing glucose levels to support healthy digestion, Low GI snacks for kids inflammation, and boost the immune system.

Cihrus Note: The articles aurantum this airantium are automatically generated by our Weight management for golfers system. While we strive immne accuracy, Citruz articles aurantjum not Citrus aurantium for immune health immine information and aurantiu be used for informational purposes only.

Aueantium recommend consulting verified Accelerated fat breakdown or experts for accurate ror reliable aurantkum.

Neoeriocitrin is a Natural lice remedies supplement that is used to support healthy liver function and Citeus. It is also used to help reduce Citrhs and improve overall immunf.

Neoeriocitrin is a dietary supplement that aurzntium used in the food industry auranitum a natural preservative auratnium flavor Maximized energy expenditure. Cor is used to extend the shelf life of Citrus aurantium for immune health products and Immunf add a citrus flavor to them.

It is also used Maximized energy expenditure an antioxidant immuen help protect food from oxidation and to help preserve its nutritional value. Forr is also Maximized energy expenditure fof a healty to give food Immuen a yellow or Oats and hair health hue.

Neoeriocitrin is a natural dietary supplement that has Cittrus found to have a number of health benefits. It has been shown to help reduce inflammation, improve digestion, and boost the immune system. It may also help to reduce cholesterol levels, improve blood sugar levels, and reduce the risk of certain types of cancer.

Additionally, it has been found to have antioxidant properties, which can help protect the body from free radical damage. Neoeriocitrin is a dietary supplement derived from citrus fruits, such as lemons and oranges. It is used to treat a variety of ailments, including colds, flu, and digestive issues.

However, it can also have some serious side effects. These include increased risk of bleeding, liver damage, and allergic reactions.

It can also interact with certain medications, such as blood thinners, and can cause dangerous interactions. It is important to speak with a doctor before taking any dietary supplement, including Neoeriocitrin, to ensure it is safe for you to take.

Vitamin C tablets, Neoeriocitrin capsules, Neoeriocitrin powder, Neoeriocitrin chewable tablets, Neoeriocitrin liquid drops. Neoeriocitrin is not a dietary supplement that is regulated across the world.

However, it is regulated in some countries, such as the United States, where it is classified as a dietary ingredient and is subject to the regulations of the Dietary Supplement Health and Education Act DSHEA.

In other countries, such as the European Union, Neoeriocitrin is not regulated as a dietary supplement, but is instead regulated as a food additive. Tags: Vitamins.

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Health benefits of Neoeriocitrin? What are the dangers of Neoeriocitrin? Example products containing Neoeriocitrin : Vitamin C tablets, Neoeriocitrin capsules, Neoeriocitrin powder, Neoeriocitrin chewable tablets, Neoeriocitrin liquid drops.

How is Neoeriocitrin regulated across the world? Upcoming Free Webinar Regulatory Change Management in Explore More Content Herbal Aminoacid Nutritional Probiotics Minerals Herb Antioxidants Protein Nootropic All tags.

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: Citrus aurantium for immune health

The Benefits of Orange Essential Oil and How to Use

Orange extract is a great herbal medicine for asthma and pneumonia. Citrus Aurantium Orange. Citrus Aurantium Orange Liquid Extracts.

Scientific Name:. Benefits: Orange is one of the richest sources of vitamin C, which is an anti-oxidant and detoxifying agent that destroys or neutralizes the free radicals in our body, thus boosting our immune system.

One of the main functions of anti-oxidants is to prevent cancer and maintain the blood sugar levels, which in turns manages cholesterol level and improve cardiovascular health. Orange juice also improves our blood circulation and prevents kidney stones.

This citrus juice helps in boosting immunity, an antioxidant presents in juice refresh your skin health by fighting against free radicals. It reduces the risk of cancer, improves vision, and good for weight management.

Herbal Extracts Best Selling. Tinospora cordifolia Giloy View Product. Arctostaphylos uva-ursi Bearberry View Product.

Vitex agnus-castus ChasteBerry View Product. Bromelain View Product. Nano Curcumin View Product. Berberis aristata Daruhaldi View Product.

Triphala View Product. Andrographis Paniculata Kalmegh View Product. Phyllanthus Niruri Bhumi Amla View Product. Senna Alexandrina Senna View Product.

Morinda Citrifolia Noni View Product. Glycyrrhiza Glabra Mulethi View Product. Oil Soluble Extracts Best Selling. Emblica Officinalis Amla View Product. Eucalyptus Globulus Nilgiri View Product. Diyala J Pure Sci — IJRDO-J Biol Sci — He XG, Lian LZ, Lin LZ, Bernart MW High-performance liquid chromatography-electrospray mass spectrometry in phytochemical analysis of sour orange Citrus aurantium L.

J Chromatogr A — Arlette NT, Anangmo N, Nadia C, Gertrude MT, Stephanie MT, Pone W The in vitro anticoccidial activity of aqueous and ethanolic extracts of Ageratum conyzoide sand Vernonia amygdalina Asteraceae.

World J Pharm Pharm Sci — Evid Based Complement Alternat Med. Malleshappa P, Kumaran RC, Venkatarangaiah K, Parveen S Peels of Citrus fruits: a potential source of anti-inflammatory and anti-nociceptive agents. Pharm J S—S Jain S, Arora P, Popli H A comprehensive review on Citrus aurantifolia essential oil: its phytochemistry and pharmacological aspects.

Braz J Nat Sci Aladekoyi G, Omosulis V, OrungbemiO O Evaluation of antimicrobial activity of oil extracted from three different citrus seeds Citrus limon , Citrus aurantifolia and Citrus aurantium.

Int J Sci Res Eng Stud — Kačániová M, Terentjeva M, Galovičová L et al Biological activity and antibiofilm molecular profile of Citrus aurantium essential oil and its application in a food model.

Benzaid C, Belmadani A, Tichati L, Djeribi R, Rouabhia M Effect of Citrus aurantium L. Essential oil on streptococcus mutans growth, biofilm formation and virulent genes expression. Antibiotics — Karabiyikli Ş, Deǧirmenci H, Karapinar M Inhibitory effect of sour orange Citrus aurantium juice on salmonella typhimurium and listeria monocytogenes.

LWT — Gopal PV Evaluation of anti-microbial activity of Citrus aurantium against some gram positive and negative bacterial strains. Pharmacia — Haraoui N, Allem R, Chaouche TM, Belouazni A In-vitro antioxidant and antimicrobial activities of some varieties citrus grown in Algeria.

Adv Tradit Med — Teneva D, Denkova-Kostova R, Goranov B, Hristova-Ivanova Y, Slavchev A, Denkova Z, Kostov G Chemical composition, antioxidant activity and antimicrobial activity of essential oil from Citrus aurantium L zest against some pathogenic microorganisms.

Z Naturforsch C J Biosci — Clavaud C, Jourdain R, Bar-Hen A et al Dandruff is associated with disequilibrium in the proportion of the major bacterial and fungal populations colonizing the scalp. PLoS One. J Food Sci. Lobo V, Patil A, Phatak A, Chandra N Free radicals, antioxidants and functional foods: impact on human health.

Pharmacogn Rev — Shi Z, Li T, Liu Y, Cai T, Yao W, Jiang J, He Y, Shan L Hepatoprotective and anti-oxidative effects of total flavonoids from Qu Zhi Qiao fruit of Citrus Paradisi cv. Changshanhuyou on nonalcoholic steatohepatitis in vivo and in vitro through Nrf2-ARE signaling pathway.

Bendaha H, Bouchal B, El Mounsi I, Salhi A, Berrabeh M, El Bellaoui M, Mimouni M Chemical composition, antioxidant, antibacterial and antifungal activities of peel essential oils of Citrus aurantium grown in Eastern Morocco.

Pharm Lett — Bian Y, Chen X, Cao H et al A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer. Chin Med United Kingdom — Yao L, Zhang X, Huang C, Cai Y, Wan C The effect of Citrus aurantium on non-small-cell lung cancer: a research based on network and experimental pharmacology.

Shen C-Y, Yang L, Jiang J-G, Zheng C-Y, Zhu W Immune enhancement effects and extraction optimization of polysaccharides from Citrus aurantium L. amara Engl.

Food Funct — Han MH, Lee WS, Lu JN, Kim G, Jung JM, Ryu CH, Kim GIY, Hwang HJ, Kwon TK, Choi YH Citrus aurantium L. exhibits apoptotic effects on U human leukemia cells partly through inhibition of Akt. Int J Oncol — Arbo MD, Schmitt GC, Limberger MF, Charão MF, Moro ÂM, Ribeiro GL, Dallegrave E, Garcia SC, Leal MB, Limberger RP Subchronic toxicity of Citrus aurantium L.

Rutaceae extract and p-synephrine in mice. Schmitt GC, Arbo MD, Lorensi AL, Maciel ÉS, Krahn CL, Mariotti KC, Dallegrave E, Leal MB, Limberger RP Toxicological effects of a mixture used in weight loss products: P-synephrine associated with ephedrine, salicin, and caffeine.

Int J Toxicol — Stohs SJ Safety, efficacy, and mechanistic studies regarding Citrus aurantium bitter orange extract and p-synephrine.

Penzak SR, Jann MW, Cold JA, Hori YY, Desai HD, Gurley BJ Seville sour orange juice: synephrine content and cardiovascular effects in normotensive adults.

J Clin Pharmacol — Kang P, Ryu KH, Lee JM, Kim HK, Seol GH Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L.

Biomed Pharmacother — Park J, Kim HL, Jung Y, Ahn KS, Kwak HJ, Um JY Bitter orange Citrus aurantium linné improves obesity by regulating adipogenesis and thermogenesis through AMPK activation. Nutrients — Stohs SJ, Preuss HG, Shara M A review of the human clinical studies involving Citrus aurantium bitter orange extract and its primary protoalkaloid p-synephrine.

Int J Med Sci — Li XY, Hao YF, Hao ZX, Jiang JG, Liu Q, Shen Q, Liu L, Yi YK, Shen CY Inhibitory effect of chloroform extracts from Citrus aurantium L.

on fat accumulation. Phytomedicine Verpeut JL, Walters AL, Bello NT Citrus aurantium and Rhodiola rosea in combination reduce visceral white adipose tissue and increase hypothalamic norepinephrine in a rat model of diet-induced obesity.

Nutr Res — Jia S, Hu Y, Zhang W, Zhao X, Chen Y, Sun C, Li X, Chen K Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L.

in diabetic KK-Ay mice. Zhang J, Sun C, Yan Y, Chen Q, Luo F, Zhu X, Li X, Chen K Purification of naringin and neohesperidin from Huyou Citrus changshanensis fruit and their effects on glucose consumption in human HepG2 cells.

Campbell JIA, Mortensen A, Mølgaard P Tissue lipid lowering-effect of a traditional Nigerian anti-diabetic infusion of Rauwolfia vomitoria foilage and Citrus aurantium fruit. Jiang J, Yan L, Shi Z, Wang L, Shan L, Efferth T Hepatoprotective and anti-inflammatory effects of total flavonoids of Qu Zhi Ke peel of Citrus changshan-huyou on non-alcoholic fatty liver disease in rats via modulation of NF-κB and MAPKs.

Wang J, Li T, Cai H, Jin L, Li R, Shan L, Cai W, Jiang J Protective effects of total flavonoids from Qu Zhi Qiao fruit of Citrus paradisi cv.

Biomed Pharmacother. Yu L, Hong W, Lu S, Li Y, Guan Y, Weng X, Feng Z The NLRP3 inflammasome in non-alcoholic fatty liver disease and steatohepatitis: therapeutic targets and treatment. Chen S, Jiang J, Chao G, Hong X, Cao H, Zhang S Pure Total flavonoids from citrus protect against nonsteroidal anti-inflammatory drug-induced small intestine injury by promoting autophagy in vivo and in vitro.

He B, Jiang J, Shi Z et al Pure total flavonoids from citrus attenuate non-alcoholic steatohepatitis via regulating the gut microbiota and bile acid metabolism in mice. Biomed Pharmacother Merah O, Sayed-ahmad B, Talou T, Saad Z, Cerny M, Grivot S, Evon P, Hijazi A Biochemical composition of cumin seeds, and biorefining study.

Biomol Ther — Garg C, Khurana P, Garg M Molecular mechanisms of skin photoaging and plant inhibitors. Int J Green Pharm S—S Zhang S, Duan E Fighting against skin aging: the way from bench to bedside.

Cell Transplant — Opinion S Scientific Opinion on safety evaluation of Ephedra species for use in food. EFSA J — Fugh-berman A, Myeres A Citrus aurantium , an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research. Exp Biol Med Maywood — Palamar J How ephedrine escaped regulation in the United States: a historical review of misuse and associated policy.

Health Policy —9. Thomas JE, Munir JA, McIntyre PZ, Ferguson MA STEMI in a year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J — Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, Rhodes SL, Jungvig L, Gagné J Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis.

JAMA — Haller CA, Benowitz NL Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med — Ruiz-Moreno C, Del CJ, Giráldez-Costas V, González-García J, Gutiérrez-Hellín J Effects of p-synephrine during exercise: a brief narrative review.

Nutrients —9. Malhotra S, Bailey DG, Paine MF, Watkins PB Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins.

Clin Pharmacol Ther — Bent S, Padula A, Neuhaus J Safety and efficacy of citrus aurantium for weight loss. Am J Cardiol — Bouchard NC, Howland MA, Greller HA, Hoffman RS, Nelson LS Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine.

Mayo Clin Proc — Firenzuoli F, Gori L, Galapai C Adverse reaction to an adrenergic herbal extract Citrus aurantium. Phytomedicine — Gange CA, Madias C, Felix-Getzik EM, Weintraub AR, Estes NAM Variant angina associated with bitter orange in a dietary supplement.

Gray S, Woolf AD Citrus aurantium used for weight loss by an adolescent with anorexia nervosa. J Adolesc Health — Haaz S, Fontaine KR, Cutter G, Limdi N, Perumean-Chaney S, Allison DB Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes Rev — Holmes RO, Tavee J Vasospasm and stroke attributable to ephedra-free xenadrine: case report.

Mil Med — Inchiosa MA Experience mostly negative with the use of sympathomimetic agents for weight loss. J Obes. Nasir JM, Durning SJ, Ferguson M, Barold HS, Haigney MC Exercise-induced syncope associated with QT prolongation and ephedra-free Xenadrine.

Nykamp DL, Fackih MN, Compton AL Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Ann Pharmacother — Rossato LG, Costa VM, Limberger RP, Bastos M de L, Remião F Synephrine: from trace concentrations to massive consumption in weight-loss.

Food Chem Toxicol — Stephensen TA, Sarlay R Ventricular fibrillation associated with use of synephrine containing dietary supplement. Stohs SJ Assessment of the adverse event reports associated with Citrus aurantium bitter orange from April to October J Funct Foods — Sultan S, Spector J, Mitchell RM Ischemic colitis associated with use of a bitter orange — containing dietary weight-loss supplement.

Consum Rep — Dosoky NS, Setzer WN Biological activities and safety of Citrus spp. Essential oils. Int J Mol Sci — Opdyke DLJ Monographs on fragrance raw materials. Food Cosmet Toxicol — Rudzki E, Grzywa Z, Bruo WS Sensitivity to 35 essential oils.

Contact Dermatitisitis — Rudazki E, Grzywa Z, Bruo WS Sensitivity to 35 essential oils. Contact Dermatitis — Ogunro OB, Oyeyinka BO, Gyebi GA, Batiha GE-S Nutritional benefits, ethnomedicinal uses, phytochemistry, pharmacological properties and toxicity of Spondias mombin Linn: a comprehensive review.

J Pharm Pharmacol. Izah SC, Etim NG, Ilerhunmwuwa IA, Ibibo TD, Udumo JJ Activities of express extracts of costus afer Ker—Gawl.

Int J Pharm Phytopharmacol Res eIJPPR — Izah SC, Chandel SS, Epidi JO, Devaliya R Biocontrol of Anopheles gambiae larvae using fresh ripe and unripe fruit extracts of Capsicum frutescens var.

Int J Green Pharm —7. Chibueze Izah S, Singh Chandel S, Etim NG, Epidi O, Venkatachalam T, Devaliya R Potency of unripe and ripe express extracts of long pepper Capsicum frutescens var. baccatum against some common pathogens. Int J Pharm Phytopharmacol Res — Izah SC, Uhunmwangho EJ, Etim NG Antibacterial and synergistic potency of methanolic leaf extracts of Vernonia amygdalina L.

and Ocimum gratissimum L. Chibueze Izah S Studies on the synergistic effectiveness of methanolic extract of leaves and roots of Carica papaya L. papaya against some bacteria pathogens. Int J Complement Altern Med — Chibueze Izah S Synergy of methanolic leave and stem-back extract of Anacardium occidentale L.

cashew against some enteric and superficial bacteria pathogens. MOJ Toxicol — Karthikeyan V, Karthikeyan J Citrus aurantium bitter orange : a review of its traditional uses, phytochemistry and pharmacology.

Int J Drug Discov Herb Res — Palazzolo E, Armando Laudicina V, Antonietta Germanà M Current and potential use of citrus essential oils. Curr Org Chem — Download references. Reproductive and Endocrinology, Toxicology, and Bioinformatics Research Laboratory, Department of Biological Sciences, KolaDaisi University, Ibadan, Oyo State, Nigeria.

Department of Community Medicine, Faculty of Clinical Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria. Department of Microbiology, Faculty of Science, Bayelsa Medical University, Yenagoa, Bayelsa State, Nigeria.

Department of Disease Control and Immunization, Bayelsa State Primary Health Care Board, Yenagoa, Bayelsa State, Nigeria. Department of Chemical Sciences, Crown-Hill University, Eiyenkorin, Kwara State, Nigeria. Department of Zoology, Cooch Behar Panchanan Barma University, Cooch Behar, West Bengal, India.

You can also search for this author in PubMed Google Scholar. Correspondence to Olalekan Bukunmi Ogunro. Department of Microbiology, Bayelsa Medical University, Yenagoa, Bayelsa, Nigeria. Department of Sustainable Development, Appalachian State University, Boone, USA.

Government College, University of Faisalabad, Islamabad, Pakistan. Reprints and permissions. Ogunro, O. Citrus aurantium : Phytochemistry, Therapeutic Potential, Safety Considerations, and Research Needs.

In: Izah, S. eds Herbal Medicine Phytochemistry. Reference Series in Phytochemistry. Springer, Cham. Received : 10 September Accepted : 17 September Published : 10 November Publisher Name : Springer, Cham.

Print ISBN : Online ISBN : eBook Packages : Springer Reference Biomedicine and Life Sciences Reference Module Biomedical and Life Sciences.

Policies and ethics. Skip to main content. Abstract Citrus aurantium , commonly referred to as sour orange or bitter orange, holds significant importance both in biological and economic terms. Keywords Citrus aurantium Bitter orange Phytochemicals Non-pharmacological uses Economic relevance.

Abbreviations ALT: Alanine transminase AMPKα: Activated protein kinase alpha AMPKα: AMP-activated protein kinase alpha AST: Aspartate aminotransferase CAVAPs: Crude polysaccharides of C. aurantium L. Amara Engls DPPH: 2,2-Diphenylpicrylhydrazyl ERK: Extracellular signal- regulated kinase EtOAc: Ethyl acetate FAS: Fatty acid synthase FDA: Food and Drug Administration FRAP: Ferric reducing antioxidant power GGT: Gamma-glutamyl transferase GSK3β: Glycogen Synthase Kinase 3 Beta IL-1β: Interleukin-1β IL Interleukin 6 iNOS: Inducible nitric oxide synthase JNK: c-Jun N-terminal kinase MAPK: Mitogen-activated protein kinase MTD: Maximum tolerated dose NAFLD: Non-alcohol fatty liver disease NASH: Non-alcoholic steatohepatitis NF-kB: Nuclear factor kappa B NOAEL: No-observed-adverse-effect-level NOEL: No-observed-effect-level Nrf2: Nuclear factor erythroid 2-related factor 2 ORAC: Oxygen radical absorbance capacity PGC-1α: PPARγ co-activator 1α PTFC: Pure total flavonoids from citrus SCD1: Stearoyl-CoA desaturase 1 TAC: Total antioxidant capacity TBARS: Thiobarbituric acid reactive substances TNF- α: Tumor necrosis factor α UCP1: Uncoupling protein-1 WADA: World Anti-Doping Agency.

CRC Press, Boca Raton, pp — Chapter Google Scholar Abbaspoor Z, Siahposh A, Javadifar N, Faal SS, Mohaghegh Z, Sharifipour F The effect of Citrus aurantium aroma on the sleep quality in postmenopausal women: a randomized controlled trial. IJCBNM —95 PubMed Google Scholar Abdollahi F, Mohaddes Ardebili F, Najafi Ghezelje T, Hosseini F The effect of aaromatherapy with bitter orange extract on sleep quality in patient with type 2 diabetic.

Complement Med J — Google Scholar Mohammadi F, Moradi M, Niazi A, Jamali J The impact of aromatherapy with Citrus aurantium essential oil on sleep quality in pregnant women with sleep disorders: a randomized controlled clinical trial.

Int J Community Based Nurs Midwifery — PubMed Google Scholar da Camara CAG, Akhtar Y, Isman MB, Seffrin RC, Born FS Repellent activity of essential oils from two species of Citrus against Tetranychus urticae in the laboratory and greenhouse.

Crop Prot — Article Google Scholar El-Akhal F, El Ouali LA, Guemmouh R Larvicidal activity of essential oils of Citrus sinensis and Citrus aurantium Rutaceae cultivated in Morocco against the malaria vector Anopheles labranchiae Diptera: Culicidae. Asian Pac J Trop Dis — Article Google Scholar Barragan Ferrer D, Rimantas Venskutonis P, Talou T, Zebib B, Manuel Barragan Ferrer J, Merah O Identification and in vitro activity of bioactive compounds extracted from Tussilago farfara L.

Google Scholar Anwar S, Ahmed N, Speciale A, Cimino F, Saija A Bitter orange Citrus aurantium L. Fruits — Article CAS Google Scholar Karoui IJ, Wannes WA, Marzouk B Refined corn oil aromatization by Citrus aurantium peel essential oil.

Ind Crop Prod — Article CAS Google Scholar Nguyen H, Campi EM, Roy Jackson W, Patti AF Effect of oxidative deterioration on flavour and aroma components of lemon oil. Food Chem — Article CAS Google Scholar Oulebsir C, Mefti-Korteby H, Djazouli ZE, Zebib B, Merah O Essential oil of Citrus aurantium L.

Cardiovasc Toxicol — Article CAS PubMed Google Scholar Stohs SJ, Preuss HG, Shara M The safety of Citrus aurantium bitter orange and its primary protoalkaloid p-synephrine.

Phytother Res — Article CAS PubMed Google Scholar Louw VJ, Louw H Citrus aurantium — beware of the bitter orange. Toxicol Rep — Article CAS PubMed Google Scholar Deshmukh NS, Stohs SJ, Magar CC, Kadam SB Citrus aurantium bitter orange extract: safety assessment by acute and day oral toxicity studies in rats and the Ames Test for mutagenicity.

Cardiovasc Toxicol — Article PubMed Google Scholar Teshome E, Forsido SF, Rupasinghe HPV, Olika Keyata E Potentials of natural preservatives to enhance food safety and shelf life: a review.

J Oleo Sci — Article Google Scholar Friedman M, Henika PR, Levin CE, Mandrell RE Antibacterial activities of plant essential oils and their components against Escherichia coli OH7 and Salmonella enterica in apple juice. J Agric Food Chem — Article CAS PubMed Google Scholar Iturriaga L, Olabarrieta I, de Marañón IM Antimicrobial assays of natural extracts and their inhibitory effect against Listeria innocua and fish spoilage bacteria, after incorporation into biopolymer edible films.

Int J Food Microbiol —64 Article CAS PubMed Google Scholar Kim J, Marshall MR, Wei C, i. J Agric Food Chem — Article CAS Google Scholar Bensid A, El Abed N, Houicher A, Regenstein JM, Özogul F Antioxidant and antimicrobial preservatives: properties, mechanism of action and applications in food—a review.

Crit Rev Food Sci Nutr — Article CAS PubMed Google Scholar Aazza S, Lyoussi B, Miguel MG Antioxidant and antiacetylcholinesterase activities of some commercial essential oils and their major compounds. Molecules — Article CAS PubMed Google Scholar Sarrou E, Chatzopoulou P, Dimassi-Theriou K, Therios I Volatile constituents and antioxidant activity of peel, flowers and leaf oils of Citrus aurantium L.

Molecules — Article CAS PubMed Google Scholar Jabri Karoui I, Marzouk B Characterization of bioactive compounds in Tunisian bitter orange Citrus aurantium L. J Sci Food Agric — Article CAS PubMed Google Scholar Agarwal P, Sebghatollahi Z, Kamal M, Dhyani A, Shrivastava A, Singh KK, Sinha M, Mahato N, Mishra AK, Baek KH Citrus essential oils in aromatherapy: therapeutic effects and mechanisms.

J Herb Med Article Google Scholar Suryawanshi JAS An overview of Citrus aurantium used in treatment of various diseases. African J Plant Sci — Google Scholar Ersus S, Cam M Determination of organic acids, total phenolic content, and antioxidant capacity of sour Citrus aurantium fruits.

Chem Nat Compd — Article CAS Google Scholar Zhang C, Bucheli P, Liang X, Lu Y Citrus flavonoids as functional ingredients and their role in traditional Chinese medicine. Global Science Books CAS Google Scholar Seiyaboh EI, Seiyaboh Z, Izah SC Environmental control of mosquitoes: a case study of the effect of Mangifera indica root-bark extracts family Anacardiaceae on the larvae of Anopheles gambiae.

Ann Ecol Environ Sci —38 Google Scholar Seiyaboh EI, Odubo TC, Izah SC Larvicidal activity of Tetrapleura tetraptera Schum and Thonn Taubert Mimosaceae extracts against Anopheles gambiae. Int J Adv Res Microbiol Immunol —25 Google Scholar Youkparigha FO, Izah SC Larvicidal efficacy of aqueous extracts of Zingiber officinale Roscoe ginger against malaria vector, Anopheles gambiae Diptera: Culicidae.

Int J Environ Agric Sci —6 Google Scholar Izah SC Activities of crude, acetone and ethanolic extracts of Capsicum frutescens var. J Environ Treat Techn — Google Scholar Ogunro OB, Salawu AO, Alotaibi SS, Albogami SM, Batiha G-S, Waard MD QuercetinO-β-D-glucopyranoside-rich fraction from Spondias mombin leaves halted responses from oxidative stress, neuroinflammation, apoptosis, and lipid peroxidation in the brain of Dichlorvos-treated Wistar rats.

Toxics —22 Article Google Scholar Siskos EP, Konstantopoulou MA, Mazomenos BE, Jervis M Insecticidal activity of Citrus aurantium fruit, leaf, and shoot extracts against adult olive fruit flies Diptera: Tephritidae.

J Econ Entomol — Article CAS PubMed Google Scholar Yao WR, Wang HY, Wang ST, Sun SL, Zhou J, Luan YY Assessment of the antibacterial activity and the antidiarrheal function of flavonoids from bayberry fruit. J Agric Food Chem — Article CAS PubMed Google Scholar Hansen DK, George NI, White GE, Pellicore LS, Abdel-Rahman A, Fabricant D Physiological effects following administration of Citrus aurantium for 28 days in rats.

Toxicol Appl Pharmacol — Article CAS PubMed Google Scholar Enaregha EB, Chibueze Izah S, Okiriya Q Antibacterial properties of Tetrapleura tetraptera pod against some pathogens. Res Rev Insights —4 Article Google Scholar Kigigha LT, Uhunmwangho EJ, Izah SC Assessment of hot water and ethanolic leaf extracts of Cymbopogon citrates Stapf lemon grass against selected bacteria pathogens.

Ann Microbiol Infect Dis —8 Article Google Scholar Kigigha LT, Selekere RE, Izah SC Antibacterial and synergistic efficacy of acetone extracts of Garcinia kola Bitter kola and Buchholzia coriacea Wonderful kola.

J Basic Pharmacol Toxicol —17 Google Scholar Chibueze Izah S, Aseibai ER Antibacterial and synergistic activities of methanolic leaves extract of lemon grass Cymbopogon citratus and rhizomes of ginger Zingiber officinale against Escherichia coli , Staphylococcus aureus and Bacillus subtilis. Acta Sci Microbiol —30 Google Scholar Chibueze Izah S Some determinant factors of antimicrobial susceptibility pattern of plant extracts.

Res Rev Insights —4 Article Google Scholar Yakubu MT, Ogunro OB, Ademola AR, Awakan OJ, Oyewo EB, Muhammad NO, Ajiboye TO Fadogia Agrestis Schweinf. Nigerian J of Biochem and Mol Bio 32 2 — Google Scholar Yakubu MT, Ogunro BO, Ademola RA, Awakan JO, Oyewo EB, Muhammad NO, Ajiboye TO Fadogia agrestis Schweinf.

Niger J Biochem Mol Biol — Google Scholar Maksoud S, Abdel-Massih RM, Rajha HN, Louka N, Chemat F, Barba FJ, Debs E Citrus aurantium L.

Phytother Res — Article CAS PubMed Google Scholar Jayaprakasha GK, Mandadi KK, Poulose SM, Jadegoud Y, Nagana Gowda GA, Patil BS Novel triterpenoid from Citrus aurantium L. Bioorg Med Chem — Article CAS PubMed Google Scholar De Moraes Pultrini A, Almeida Galindo L, Costa M Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L.

Biol Pharm Bull — Article Google Scholar Gholivand MB, Piryaei M, Abolghasemi MM Analysis of volatile oil composition of Citrus aurantium L. J Nat Prod Plant Resour —23 Google Scholar Khettal B, Kadri N, Tighilet K, Adjebli A, Dahmoune F, Maiza-Benabdeslam F Phenolic compounds from Citrus leaves: antioxidant activity and enzymatic browning inhibition.

J Ethnopharmacol —94 Article CAS PubMed Google Scholar Singh B, Singh JP, Kaur A, Yadav MP Insights into the chemical composition and bioactivities of citrus peel essential oils.

Food Res Int Article CAS PubMed Google Scholar Kusuma HS, Putra AFP, Mahfud M Comparison of two isolation methods for essential oils from orange peel Citrus auranticum L as a growth promoter for fish: microwave steam distillation and conventional steam distillation. J Aquac Res Dev —5 Google Scholar Hosseini SS, Khodaiyan F, Kazemi M, Najari Z Optimization and characterization of pectin extracted from sour orange peel by ultrasound assisted method.

Int J Biol Macromol — Article CAS PubMed Google Scholar Hosseini SS, Khodaiyan F, Yarmand MS Optimization of microwave assisted extraction of pectin from sour orange peel and its physicochemical properties.

Carbohydr Polym —65 Article CAS PubMed Google Scholar Burnett CL, Fiume MM, Bergfeld WF et al Safety assessment of citrus-derived peel oils as used in cosmetics. Int J Toxicol S—59S Article CAS PubMed Google Scholar Hamedi A, Zarshenas MM, Jamshidzadeh A, Ahmadi S, Heidari R, Pasdran A Citrus aurantium bitter orange seed oil: pharmacognostic, anti-inflam- matory, and anti-nociceptive properties.

Herb Prod — CAS Google Scholar Abou Baker DH, Ibrahim BMM, Hassan NS, Yousuf AF, El Gengaihi S Exploiting Citrus aurantium seeds and their secondary metabolites in the management of Alzheimer disease.

Toxicol Rep — Article CAS PubMed Google Scholar Moulehi I, Bourgou S, Ourghemmi I, Tounsi MS Variety and ripening impact on phenolic composition and antioxidant activity of mandarin Citrus reticulate Blanco and bitter orange Citrus aurantium L.

Agriculture Switzerland —9 Google Scholar Karimi E, Oskoueian E, Hendra R, Oskoueian A, Jaafar HZE Phenolic compounds characterization and biological activities of Citrus aurantium bloom. Molecules — Article CAS PubMed Google Scholar Değirmenci H, Erkurt H Relationship between volatile components, antimicrobial and antioxidant properties of the essential oil, hydrosol and extracts of Citrus aurantium L.

J Infect Public Health —67 Article PubMed Google Scholar Pasandideh S, Arasteh A Evaluation of antioxidant and inhibitory properties of Citrus aurantium L. Int J Biol Macromol — Article CAS PubMed Google Scholar Mohagheghniapour A, Saharkhiz MJ, Golmakani MT, Niakousari M Variations in chemical compositions of essential oil from sour orange Citrus aurantium L.

Sustain Chem Pharm — Article Google Scholar Yan Y, Zhou H, Wu C, Feng X, Han C, Chen H, Liu Y, Li Y Ultrasound-assisted aqueous two-phase extraction of synephrine, naringin, and neohesperidin from Citrus aurantium L. Prep Biochem Biotechnol — Article CAS PubMed Google Scholar Ishaq A, Sani D, Abdullahi S, Jatau I In vitro anticoccidial activity of ethanolic leaf extract of Citrus aurantium L.

Sokoto J Vet Sci —43 Google Scholar Rauf A, Uddin G, Ali J Phytochemical analysis and radical scavenging profile of juices of Citrus sinensis , Citrus anrantifolia , and Citrus limonum. Org Med Chem Lett Article PubMed Google Scholar Gunwantrao BB, Bhausaheb SK, Ramrao BS, Subhash KS Antimicrobial activity and phytochemical analysis of orange Citrus aurantium L.

Ann Phytomed Int J — Article CAS Google Scholar Babajide AB, Adebolu TT, Oladunmoye MK, Oladejo BO Evaluation of antibacterial activity of Citrus aurantium L.

Microbes Infect Dis — CAS Google Scholar Khudhair AMAAA, Minnat T, Jalyl O Phytochemical analysis and inhibitory effect of Citrus aurantium L.

IJRDO-J Biol Sci —23 Google Scholar He XG, Lian LZ, Lin LZ, Bernart MW High-performance liquid chromatography-electrospray mass spectrometry in phytochemical analysis of sour orange Citrus aurantium L.

J Chromatogr A — Article CAS Google Scholar Arlette NT, Anangmo N, Nadia C, Gertrude MT, Stephanie MT, Pone W The in vitro anticoccidial activity of aqueous and ethanolic extracts of Ageratum conyzoide sand Vernonia amygdalina Asteraceae. Pharm J S—S CAS Google Scholar Jain S, Arora P, Popli H A comprehensive review on Citrus aurantifolia essential oil: its phytochemistry and pharmacological aspects.

Braz J Nat Sci Article Google Scholar Aladekoyi G, Omosulis V, OrungbemiO O Evaluation of antimicrobial activity of oil extracted from three different citrus seeds Citrus limon , Citrus aurantifolia and Citrus aurantium. Int J Sci Res Eng Stud —20 Google Scholar Kačániová M, Terentjeva M, Galovičová L et al Biological activity and antibiofilm molecular profile of Citrus aurantium essential oil and its application in a food model.

Molecules —21 Article Google Scholar Benzaid C, Belmadani A, Tichati L, Djeribi R, Rouabhia M Effect of Citrus aurantium L.

LWT — Article Google Scholar Gopal PV Evaluation of anti-microbial activity of Citrus aurantium against some gram positive and negative bacterial strains.

Pharmacia — Google Scholar Haraoui N, Allem R, Chaouche TM, Belouazni A In-vitro antioxidant and antimicrobial activities of some varieties citrus grown in Algeria.

Orange Essential Oil Uses, Benefits, and Safety Citrus Aurantium Orange Liquid Extracts. Aβ plays a major role in the development of AD, particularly the neurotoxic Aβ 1—42 Rudazki E, Grzywa Z, Bruo WS Sensitivity to 35 essential oils. Therefore, it is important to reduce the level of AchE, which is used as a marker for the cholinergic nervous system. In , researchers assessed if a blend of ginger and orange essential oil could help with knee pain when applied to the skin. Aβ 1—42 protein is a fragment of the full-length Aβ that can cause inflammation and synaptic toxicity by initiating different biochemical cascades 8 , 9.
Viewed Products We recommend consulting verified sources or experts for accurate and reliable information. Benzaid C, Belmadani A, Tichati L, Djeribi R, Rouabhia M Effect of Citrus aurantium L. Figure 3. A Quiz for Teens Are You a Workaholic? PLoS One.
We include products we think Raw food selection useful for Citus readers. If you Citrus aurantium for immune health through links Citrus aurantium for immune health this imnune, we may earn a small commission. Citris only shows you brands and products that we stand behind. Essential oils are concentrated oils that are derived from plants. Several types of oils are produced from citrus species, including oranges, lemon, and grapefruit. Orange essential oil is extracted from the rind of the sweet orangeCitrus sinensis. Citrus aurantium for immune health

Citrus aurantium for immune health -

Aβ 1—42 was dissolved in sterile 0. The respective drugs were given orally p. for 4 weeks Day Based on the results of previous studies, the concentrations of CAE and nobiletin were set 3 , 13 , The passive avoidance test was conducted in all groups for 3 days Days 15—17 and Morris water maze MWM task for 7 days Days 22— The mice were performed by cardiac puncture for exsanguination after carbon dioxide anesthesia at Day 28 and were confirmed the death by observing stop breathing and cardiac dysfunction through CO 2 anesthesia and exsanguination.

The entire experimental schedule is shown in Fig. To determine learning and memory ability, the passive avoidance test was conducted in an acrylic shuttle box with two compartments and a guillotine door in the middle.

The box consists of illuminated and non-illuminated compartments with an electric grid floor that allows for electronic shock stimuli.

The test was performed on 3 consecutive days at h intervals. On the first day Day 15 , the animals were allowed to explore the non-illuminated compartment for 2 min and then transferred back to the illuminated compartment. They were then allowed to access the illuminated and non-illuminated compartment freely for 60 sec.

If the mice moved to the non-illuminated compartment, they were immediately removed and trained to adapt to the illuminated compartment. After the end of adaptation the time, on the second day, the mice moved between the two compartments for sec, but when they entered the non-illuminated compartment, the guillotine door automatically closed and a scrambled shock was given for 2 sec.

On the last day of the test, Day 17, the mice were placed in the illuminated compartment and the time taken for them to move to the non-illuminated compartment after the door opened was measured.

On Day 22, the mice were tested using the MWM task. A circular water pool was divided into quadrants; the platform was randomly located within one quadrant. The mice were trained to find the platform for 60 sec. When the mice reached the platform, they were allowed to remain on the platform for 30 sec; if they could not find the platform within 60 sec, they were guided and placed on it for 30 sec to learn the extra maze cues.

All animals performed two trials per day and the position of the platform in the circular pool was randomly changed. The task consisted of 2 days of training; 4 days of acquisition, during which the time to find the platform was recorded; and 1 day of probe trial.

For the probe trial, the platform was removed and the animals were allowed to search it for 1 min. The number of crossings by the mice in the quadrant with the removed platform was measured on Day At the end of the experiment, the mice were sacrificed, and the cortex and hippocampus were dissected from the brain.

Both tissues were rapidly homogenized and sonicated in 0. AchE activity was determined using commercial assay kits Abnova; cat. KA, Taiwan according to the manufacturer's instructions. The activity was calculated as the optical density OD at nm and represented as OD values per milligram of protein.

The dissected cortex and hippocampus tissues were lysed in radioimmunoprecipitation assay buffer containing 50 mM Tris-HCl pH 7. The supernatant was collected, and the protein concentration was calculated by bicinchoninic acid protein assay kit Thermo, USA.

The membranes were blocked with commercial blocking buffer Thermo, USA for 1 h at room temperature and washed thrice with Tris-buffered saline containing 0. After washing, the membrane was incubated at 4°C overnight with the following appropriate antibodies: B-cell lymphoma 2 Bcl-2 -associated X protein Bax; ,; cat.

The membranes were again washed thrice and enhanced using chemi-luminescence reagents. The protein bands on the membrane were detected by a chemi-luminometer ATTO, Japan. Densitometry was performed using the Image-Pro Plus soft-ware version 6. Data are expressed as the mean ± standard error and were analyzed with SPSS Statistics Different treatment groups were compared using one-way analysis of variance followed by multiple comparisons using Dunnett's post hoc test using Origin 7.

The composition in CAE were investigated the chromatographic profiles of a standard on HPLC analysis. The optimized CAE was used in all subsequent experiments. The mice did not show any change in body weight during the experiment, but hair coat showed rough condition.

Response to weak stimuli decreased and activity ability also decreased. Also, the mice was sitting on the floor with a curved posture was observed and through these symptoms, the humane endpoint was set. The animals were sacrificed by meeting the defined endpoint. The effect of CAE and nobiletin on the Aβ 1—induced memory impairment was measured using a passive avoidance task.

The step-through latency of the Aβ 1—only treated group was significantly shortened compared to the control group Fig. However, the reduced step latency with Aβ 1—42 was restored by the administration of CAE and nobiletin. Effect of nobiletin and CAE on step-through latency in passive avoidance test in Aβ 1—42 induced memory impairment.

The data are presented as mean ± standard error of the mean. Aβ, amyloid β; CAE, Citrus aurantium extract. The efficacy of CAE and nobiletin in protection from the spatial memory impairment via Aβ 1—42 injection was further confirmed.

The escape latency assessment was performed twice a day. During the test period, escape latency decreased slightly in the second trial compare to the first trial in all experimental groups Fig.

No difference was observed in the escape latency for 4 days in the amnesic mice, which were treated with Aβ 1— By contrast, the control group showed significantly decreased escape latency in two trials over 4 days Fig.

It is well-established that Aβ 1—42 induces memory loss and increases the escape latency. Similarly, the escape latency in mice administered nobiletin significantly decreased for 4 days compared to the Aβ 1—only injected group.

Effect of nobiletin and CAE on Aβ 1—42 induced memory impairment in the Morris water maze. The escape latency of A Trial 1 and B Trial 2, and the mean of C Trial 1 and Trial 2 during the training sessions for 4 days.

The effect of CAE and nobiletin treatment on the swim distance to locate the platform in the MWM task is shown in Table I. The control group mice were able to swiftly locate the platform and reached the platform during the training session.

However, the Aβ 1—treated group had difficulty learning to locate the platform. The swim distance was significantly increased compared to that of the control group. The mice in the nobiletin-treated group were also able to find the platform easily with a short swim distance, especially on Day Effect of nobiletin and CAE on the distance swum by Aβ 1—42 treated mice to find the platform in the water maze task.

To evaluate the spatial memory of the mice, the number of crossings to the platform was measured in the probe trial on Day As shown in Fig. These results show that these drugs enhance spatial cognition, learning, and memory functions against Aβ 1—induced memory impairment. Effect of nobiletin and CAE on the number of crossing in a probe trail on Day To investigate the neuroprotective effect of CAE and nobiletin on brain tissue, AchE activity was measured in the cortex and hippocampus Table II.

The AchE activity in the Aβ 1—treatment group was significantly increased compared to that in control group. Similarly, the AchE activity in the nobiletin treatment group also decreased significantly by The effect of CAE and nobiletin on the Bcl-2 family and caspase pathway was investigated in the cortex and hippocampus.

In contrast, Bcl-2 protein expression was higher in the control group than in the Aβ 1—only treated group in the cortex and hippocampus. A similar protein expression pattern was observed in the cortex.

Effect of nobiletin and CAE on protein expression in A hippocampal and B cortex tissues. The expression was detected by western blot analysis. Bax, Bcl-2 and cleaved caspase-3 protein levels were normalized by separate control β-actin, respectively.

Aβ, amyloid β; CAE, Citrus aurantium extract; Nob, Nobiletin. The present study is the first report to evaluate the neuroprotective effects in Aβ 1—induced memory impairment animal model and not the transgenic or senescence accelerated mouse model.

Our results showed that the Aβ 1—injection resulted in severe performance deficits in the passive avoidance and Morris water task as well as neurodegeneration in the mice brain that was evident from increased AchE activity in the hippocampus and cortex.

In this study, we treated the amnesic mice with CAE and nobiletin and confirmed the anti-amnesic effect by regulating of apoptotic signaling. Aβ plays a major role in the development of AD, particularly the neurotoxic Aβ 1—42 The direct injection of Aβ 1—42 in the rodent brain has been used to cause apparent memory deficits, and Aβ-exposed rats have shown hippocampus-dependent spatial learning dysfunction in long and short-term tasks 4.

Also, the brains of AD patients demonstrated a high Aβ level compared with normal aged brain samples The deposition of Aβ in the cortex and hippocampus, which are responsible for learning and memory performance, resulted in neuronal apoptosis 21 , To examine the protective effect of CAE and nobiletin, we performed the passive avoidance and MWM tasks to investigate learning and memory function.

The passive avoidance task is a method that is used to measure the escape time from the space that induces pain and fear by electronic shock in rodents It is commonly used to confirm the memory function, and we found in this study that CAE and nobiletin administration significantly increased the step-through latency to similar levels, a phenomenon that was reduced by the Aβ 1—42 injection.

The MWM is an assessment method to evaluate hippocampal-dependent learning abilities and cognitive deficits in rodents. The animals were trained to learn spatial working information at the learning stage and assisted to build future memory These results are consistent with those of previous studies that show Aβ-induced memory deficits in an MWM task than those in the saline group As a result of two trials for 4 days on the MWM task, CAE treatment reduced escape latency in the second trial compared to the first trial, and escape time decreased over training days.

The nobiletin administration group showed similar escape latency for 4 days in the first trial, and the escape latency decreased rapidly on Day 26 in the second trial. Although the pattern of escape latency of the CAE and nobiletin group was slightly different, the mean escape latency was decreased to a similar pattern.

This means that CAE and nobiletin administration showed significant decreases in escape latency, improvement in cognitive performance, and amelioration of the memory deficits. Furthermore, to investigate the neuroprotective effect of CAE and nobiletin, we examined the changes in the Ach system in the hippocampus and cortex.

Ach is an essential enzyme that maintains the normal function of the nervous system and is hydrolyzed by AchE. In addition, Aβ deposition is increased in the presence of AchE, and AchE activity in AD is related to Aβ deposition Therefore, it is important to reduce the level of AchE, which is used as a marker for the cholinergic nervous system.

Here we found that AchE activity in the cortex was similar to that of CAE and nobiletin. However, nobiletin administration showed significantly lower AchE activity than CAE administration in the hippocampus.

CAE and nobiletin administration benefits on the cholinergic neurotransmission by decreasing AchE activities in the cortex and hippocampus. AchE can also be used as a marker of apoptosis. AchE expression or activity is increased when the cells undergo apoptosis, and enhanced AchE expression levels are detected in the brain of focal cerebral ischemic rats 26 , AchE is usually present in the cytoplasm and moves to the nucleus before nuclear morphological changes occur.

It then accelerates chromatin condensation and fragmentation by modulating nuclear components Therefore, AchE can be detected on the fragmented nuclei of apoptotic cells, and increased AchE activity implies the occurrence of cell death Apoptosis is triggered via two major pathways: The mitochondrial intrinsic pathway and the death receptor-mediated extrinsic pathway.

In this study, we focused on the mitochondrial pathway, which is regulated by Bcl-2 family and caspases Bcl-2 is a known anti-apoptotic protein, while Bax is a pro-apoptotic protein that promotes apoptosis.

These two proteins are the major factors responsible for cell death regulation. The Bcl-2 and Bax ratio determines whether a cell undergoes or escapes apoptosis 23 , In our study, the Aβ 1—42 injection group had increased Bax and cleaved caspase-3 protein expressions compared with the control group, while Bcl-2 protein levels were increased in the control group and reduced in the Aβ 1—treated group.

CAE treatment significantly decreased the Bax and cleaved caspase-3 protein expression levels and simultaneously increased Bcl-2 protein expression in the hippocampus and cortex. Likewise, the treatments also increased the expression ratio of Bcl-2 to Bax in the cortex and hippocampus.

On the other hand, Bcl-2 protein expression in the nobiletin administration group was increased to a level similar to that of the control group.

Bax and cleaved caspase-3 protein expressions in the cortex were significantly inhibited by nobiletin treatment, while the Bcl-2 protein level was significantly enhanced compared the control group. In conclusion, our results indicate that the administration of CAE and nobiletin had a similar neuroprotective effect against Aβ-induced cognitive impairment through reduction of AchE activity and anti-apoptotic activity and regulating the Bcl-2 family and caspase pathway in the cortex and hippocampus.

Our results provide evidence of the dietary intake of CAE or nobiletin as a valuable functional food since it has the ability to reduce cognitive impairment and memory dysfunction. However, to confirm the neuroprotective effects of CAE and nobiletin, we have to confirm the morphological change of brain tissues in further study.

In addition, the effects of CAE and nobiletin on Aβ accumulation in cortex and hippocampus should be studied. The present study was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries IPET through High Value-added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs MAFRA; grant no.

HJL carried out the experiments and wrote the original manuscript. Sometimes, the leaves and flowers from the orange plant can be used as well. Research has shown that some essential oils may have specific health benefits. So, knowing that, what exactly are the benefits associated with orange essential oil?

And how can you use it? This means that the benefits are related to personal experience instead of being backed by scientific research. You now know some of the ways that orange essential oil can be used, but what does science say about its potential uses and benefits?

Quite a bit, actually. A study looked at the effect of orange essential oil on E. coli isolates obtained from beef. These isolates can potentially cause food poisoning.

Results indicated that after 24 hours, a 1 percent or lower concentration of orange essential oil inhibited the bacteria at refrigeration temperatures. Another study looked at the effect of orange essential oil on strains of Staphylococcus aureus staph bacteria that are resistant to antibiotics.

They found that when added to infected human cells in culture, low concentrations of orange essential oil killed the bacteria without harming the cultured cells. Orange essential oil may also prevent the growth of fungi that can cause food to spoil.

One study found that orange oil provided some protection against four species of fungi. Another study recorded activity against eight fungi that affect vegetables, although essential oils like clove and garlic were more effective.

Orange essential oil can be effective at stopping the growth of some types of bacteria and fungi. Aromatherapy with orange essential oil appears to reduce symptoms of anxiety and depression. In a study , it was found that aromatherapy with orange essential oil reduced the pulse rate and stress hormone levels in children undergoing a dental procedure.

Additionally, in a study , women in labor reported less anxiety after inhaling orange essential oil than women in the control group who inhaled distilled water. A study on mice looked at the inhalation of orange essential oils and its potential effect on depression.

The researchers found that the mice who inhaled the orange essential oil displayed fewer depression-like behaviors. Orange essential oil appears to be effective at reducing levels of stress and anxiety.

It may also be beneficial for depression, although more research is needed. A study involving people with bone fractures looked at whether inhaling orange essential oil could help with pain. Compared to a control group, people inhaling orange oil reported less pain. In , researchers assessed if a blend of ginger and orange essential oil could help with knee pain when applied to the skin.

Some small studies have indicated that using orange essential oil topically or for aromatherapy may help with short-term pain. Limonene , a component of orange essential oil, has been investigated as a potential cancer treatment. A study from found that orange oil rich in limonene both inhibited the growth and promoted the death of colon cancer cells in culture.

A study found that orange essential oil inhibited the growth of lung and prostate cancer cell lines in culture. Additionally, increased cell death was seen in the lung cancer cell line.

Orange essential oil was also observed to have antioxidant activity. Studies have indicated that orange essential oil or its components can inhibit the growth and lead to cell death in some cultured cancer cell lines.

Because these studies were done in a test tube and not in the human body, additional research is needed to learn more about these properties. A small study evaluated the effect of inhaled orange flower essential oil on exercise in student athletes.

The researchers found that people who inhaled the oil had a significant decrease in running times as well as an increase in lung function. A study on rats evaluated if orange essential oil could promote weight loss. They found that obese rats that were fed capsules of orange essential oil showed a reduction in weight gain as well as lowered cholesterol.

A study looked at the effect that orange essential oil had on housefly larvae and pupae. It was found to have insecticidal properties by both contact and fumigation. Diffusion can help you do that. A diffuser allows an essential oil to evaporate, typically using heat.

As evaporation occurs, the scent of the essential oil spreads throughout the room. There are many types of diffusers you can buy, either online or at specialty stores that sell aromatherapy products. Each type of diffuser will have its own specific set of instructions.

Be sure to carefully follow all product instructions when using your diffuser. Do you want another way to add an orange scent to a space? You can make an orange oil spray by following these steps:. Are you looking to relieve pain or inflammation?

Consider making your own massage oil infused with orange essential oil. The NAHA suggests using 20 drops of essential oil per ounce of carrier oil to make a massage oil with a 3 percent solution. Any essential oil has the potential to cause a skin reaction when applied topically.

Avoid using old or oxidized orange essential oil, which can cause dermal sensitization. Some citrus essential oils are phototoxic. This means they can cause a painful skin reaction if you use them on your skin and then go out in the sun.

Orange essential oil has a low risk of phototoxicity , but you should still exercise caution if you plan on going outside after using it on your skin.

Orange essential oil can be purchased either online or at a store that sells natural products. Follow the tips below to ensure you purchase good quality orange essential oil. Orange essential oil can be used for a variety of applications that range from lifting mood and reducing stress to adding a fresh, citrusy aroma to a room.

Research has shown that orange essential oil may have several benefits. Some examples include antimicrobial activity, pain relief, and anticancer properties.

Always be sure to use essential oils safely. Grapefruit essential oil may offer a variety of health benefits — including reduced blood pressure and stress levels.

Here are 6 benefits and uses of….

Healty orange Citrus aurantiumDance performance fueling known as sour ajrantium and Seville orange, is Yealth citrus fruit with a jmmune of uses. This article covers all you Low GI snacks for kids Cigrus know about bitter orange, including its role in weight loss and skin health, as well as its overall safety as a supplement. The bitter orange plant thrives in subtropical regions but can withstand adverse environmental conditions like frost for short periods 2. Oval or oblong in shape, the fruit is red-orange when ripe and has a distinctively thick, dimpled skin. There are 23 cultivars of the fruit, the most prominent of which is Bergamot.

Author: Grosho

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