Category: Health

Oxidative stress and diabetes

oxidative stress and diabetes

An animal model of type 1 diabetes induced by ane injection steess streptozotocin to oxidative stress and diabetes pancreatic islet β cell destruction. Clin Sci Lond. Calculated by subtracting threshold pressure from the maximum pressure recorded during micturition. Jones P. External urethral sphincter activity in diabetic rats.

Oxidative stress and diabetes -

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Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation. Richter C. Do mitochondrial DNA fragments promote cancer and aging?

FEBS Lett. Kelley EE , Khoo NK, Hundley NJ, Malik UZ, Freeman BA, Tarpey MM. Hydrogen peroxide is the major oxidant product of xanthine oxidase. Granger DN , Rutili G, McCord JM. Superoxide radicals in feline intestinal ischemia.

Godber BL , Doel JJ, Durgan J, Eisenthal R, Harrison R. A new route to peroxynitrite: a role for xanthine oxidoreductase. Vorbach C , Harrison R, Capecchi MR. Xanthine oxidoreductase is central to the evolution and function of the innate immune system. Trends Immunol. Luiking YC , Engelen MP, Deutz NE.

Regulation of nitric oxide production in health and disease. Curr Opin Clin Nutr Metab Care. Xia Y , Zweier JL. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Farmer EH , Sutton DA. The course of autoxidation reactions in polyisoprenes and allied compounds: V.

Observations on fish-oil acids. J Chem Soc. Halliwell B , Gutteridge JM. Lipid peroxidation in brain homogenates: the role of iron and hydroxyl radicals.

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. Gutteridge JM , Beard AP, Quinlan GJ. Superoxide-dependent lipid peroxidation. Problems with the use of catalase as a specific probe for fenton-derived hydroxyl radicals.

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Ann NY Acad Sci. Bielski BH , Arudi RL, Sutherland MW. The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts. Schaich KM , Borg DC.

Solvent effects in the spin trapping of lipid oxyl radicals. Garnier-Suillerot A , Tose L, Paniago E. Kinetic and mechanism of vesicle lipoperoxide decomposition by Fe II. Hardwick TJ. The rate constant of the reaction between ferrous ions and hydrogen peroxide in acid solution.

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Siriraj Med J. Moreira PI , Sayre LM, Zhu X, Nunomura A, Smith MA, Perry G. Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease. Methods Mol Biol. Rahmanto AS , Morgan PE, Hawkins CL, Davies MJ. Cellular effects of peptide and protein hydroperoxides.

Hunt JV , Dean RT, Wolff SP. Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing.

Rosenfeld ME. Inflammation, lipids, and free radicals: lessons learned from the atherogenic process. Semin Reprod Endocrinol. Steinberg D. Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis. Esterbauer H , Puhl H, Dieber-Rotheneder M, Waeg G, Rabl H. Effect of antioxidants on oxidative modification of LDL.

Ann Med. Porkkala-Sarataho EK , Nyyssönen MK, Kaikkonen JE, Poulsen HE, Hayn EM, Salonen RM, Salonen JT. A randomized, single-blind, placebo-controlled trial of the effects of mg alpha-tocopherol on the oxidation resistance of atherogenic lipoproteins.

Am J Clin Nutr. Horton AA , Fairhurst S. Lipid peroxidation and mechanisms of toxicity. Crit Rev Toxicol. Mihara M , Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. Ohkawa H , Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

Rankinen T , Hietanen E, Väisänen S, Lehtiö M, Penttilä I, Bouchard C, Rauramaa R. Relationship between lipid peroxidation and plasma fibrinogen in middle-aged men. Thromb Res. Pasaoglu H , Sancak B, Bukan N. Lipid peroxidation and resistance to oxidation in patients with type 2 diabetes mellitus.

Tohoku J Exp Med. Cavalca V , Cighetti G, Bamonti F, Loaldi A, Bortone L, Novembrino C, De Franceschi M, Belardinelli R, Guazzi MD. Oxidative stress and homocysteine in coronary artery disease. Witztum JL. The oxidation hypothesis of atherosclerosis.

Marnett LJ. Oxyradicals and DNA damage. Niedernhofer LJ , Daniels JS, Rouzer CA, Greene RE, Marnett LJ. Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. Steinberg D , Parthasarathy S, Carew TE, Khoo JC, Witztum JL.

Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. Markesbery WR , Lovell MA.

Neurobiol Aging. Staruchova M , Collins AR, Volkovova K, Mislanová C, Kovacikova Z, Tulinska J, Kocan A, Staruch L, Wsolova L, Dusinska M. Occupational exposure to mineral fibres.

Biomarkers of oxidative damage and antioxidant defence and associations with DNA damage and repair. Nair V , Cooper CS, Vietti DE, Turner GA. The chemistry of lipid peroxidation metabolites: crosslinking reactions of malondialdehyde.

Requena JR , Fu MX, Ahmed MU, Jenkins AJ, Lyons TJ, Thorpe SR. Lipoxidation products as biomarkers of oxidative damage to proteins during lipid peroxidation reactions. Nephrol Dial Transplant. Knight JA , Pieper RK, McClellan L. Specificity of the thiobarbituric acid reaction: its use in studies of lipid peroxidation.

Praticò D , Iuliano L, Mauriello A, Spagnoli L, Lawson JA, Rokach J, Maclouf J, Violi F, FitzGerald GA. Localization of distinct F2-isoprostanes in human atherosclerotic lesions.

Mallat Z , Philip I, Lebret M, Chatel D, Maclouf J, Tedgui A. Elevated levels of 8-iso-prostaglandin F2alpha in pericardial fluid of patients with heart failure: a potential role for in vivo oxidant stress in ventricular dilatation and progression to heart failure.

Lawson JA , Rokach J, FitzGerald GA. Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo. Roberts LJ , Morrow JD. The generation and actions of isoprostanes.

Reilly MP , Praticò D, Delanty N, DiMinno G, Tremoli E, Rader D, Kapoor S, Rokach J, Lawson J, FitzGerald GA. Increased formation of distinct F2 isoprostanes in hypercholesterolemia.

Mori TA , Croft KD, Puddey IB, Beilin LJ. An improved method for the measurement of urinary and plasma F2-isoprostanes using gas chromatography-mass spectrometry.

Praticò D. F 2 -isoprostanes: sensitive and specific non-invasive indices of lipid peroxidation in vivo. Li H , Lawson JA, Reilly M, Adiyaman M, Hwang SW, Rokach J, FitzGerald GA.

Gopaul NK , Anggård EE, Mallet AI, Betteridge DJ, Wolff SP, Nourooz-Zadeh J. Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus. Davì G , Ciabattoni G, Consoli A, Mezzetti A, Falco A, Santarone S, Pennese E, Vitacolonna E, Bucciarelli T, Costantini F.

In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Morrow JD , Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts LJ.

Increase in circulating products of lipid peroxidation F2-isoprostanes in smokers. Smoking as a cause of oxidative damage. Bachi A , Zuccato E, Baraldi M, Fanelli R, Chiabrando C. Basal levels in smokers and nonsmokers. Voutilainen S , Morrow JD, Roberts LJ, Alfthan G, Alho H, Nyyssönen K, Salonen JT.

Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels. Arterioscler Thromb Vasc Biol. Davi G , Alessandrini P, Mezzetti A, Minotti G, Bucciarelli T, Costantini F, Cipollone F, Bon GB, Ciabattoni G, Patrono C.

In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia. Praticò D , Tangirala RK, Rader DJ, Rokach J, FitzGerald GA.

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nat Med. Schnackenberg CG , Wilcox CS. Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin f2alpha. Palmer AM , Thomas CR, Gopaul N, Dhir S, Anggård EE, Poston L, Tribe RM.

Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mesenteric arteries of the streptozotocin-diabetic rat. Laight DW , Kengatharan KM, Gopaul NK, Anggård EE, Carrier MJ. Investigation of oxidant stress and vasodepression to glyceryl trinitrate in the obese Zucker rat in vivo.

Br J Pharmacol. The steady-state levels of oxidative DNA damage and of lipid peroxidation F2-isoprostanes are not correlated in healthy human subjects. Fujita T. Insulin resistance and salt-sensitive hypertension in metabolic syndrome.

Aldosterone in salt-sensitive hypertension and metabolic syndrome. J Mol Med Berl. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism.

Inoguchi T , Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD P H oxidase in cultured vascular cells.

Anderson RM , Weindruch R. The caloric restriction paradigm: implications for healthy human aging. Am J Hum Biol. Rebrin I , Kamzalov S, Sohal RS.

Effects of age and caloric restriction on glutathione redox state in mice. Grattagliano I , Portincasa P, Cocco T, Moschetta A, Di Paola M, Palmieri VO, Palasciano G.

Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats. Exp Gerontol. Cocco T , Sgobbo P, Clemente M, Lopriore B, Grattagliano I, Di Paola M, Villani G. Tissue-specific changes of mitochondrial functions in aged rats: effect of a long-term dietary treatment with N-acetylcysteine.

Baur JA , Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K. Resveratrol improves health and survival of mice on a high-calorie diet.

Keaney JF , Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study.

Okuno Y , Matsuda M, Kobayashi H, Morita K, Suzuki E, Fukuhara A, Komuro R, Shimabukuro M, Shimomura I.

Adipose expression of catalase is regulated via a novel remote PPARgamma-responsive region. Okuno Y , Matsuda M, Miyata Y, Fukuhara A, Komuro R, Shimabukuro M, Shimomura I. Human catalase gene is regulated by peroxisome proliferator activated receptor-gamma through a response element distinct from that of mouse.

Endocr J. Kobayashi H , Matsuda M, Fukuhara A, Komuro R, Shimomura I. Dysregulated glutathione metabolism links to impaired insulin action in adipocytes. Am J Physiol Endocrinol Metab. Roberts CK , Barnard RJ, Sindhu RK, Jurczak M, Ehdaie A, Vaziri ND. Oxidative stress and dysregulation of NAD P H oxidase and antioxidant enzymes in diet-induced metabolic syndrome.

Meng S , Roberts LJ, Cason GW, Curry TS, Manning RD. Superoxide dismutase and oxidative stress in Dahl salt-sensitive and -resistant rats.

Am J Physiol Regul Integr Comp Physiol. Kido M , Ando K, Oba S, Fujita T. Renoprotective effect of pravastatin in salt-loaded Dahl salt-sensitive rats.

Hypertens Res. Wang H , Shimosawa T, Matsui H, Kaneko T, Ogura S, Uetake Y, Takenaka K, Yatomi Y, Fujita T. Paradoxical mineralocorticoid receptor activation and left ventricular diastolic dysfunction under high oxidative stress conditions. J Hypertens. Laffer CL , Bolterman RJ, Romero JC, Elijovich F.

Effect of salt on isoprostanes in salt-sensitive essential hypertension. Rocchini AP , Key J, Bondie D, Chico R, Moorehead C, Katch V, Martin M. The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents. Uzu T , Kimura G, Yamauchi A, Kanasaki M, Isshiki K, Araki S, Sugiomoto T, Nishio Y, Maegawa H, Koya D.

Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension. Sanchez RA , Masnatta LD, Pesiney C, Fischer P, Ramirez AJ. Telmisartan improves insulin resistance in high renin nonmodulating salt-sensitive hypertensives. Giner V , Coca A, de la Sierra A.

Increased insulin resistance in salt sensitive essential hypertension. J Hum Hypertens. Dobrian AD , Schriver SD, Lynch T, Prewitt RL. Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity.

Am J Physiol Renal Physiol. Annuk M , Zilmer M, Fellström B. Endothelium-dependent vasodilation and oxidative stress in chronic renal failure: impact on cardiovascular disease. Martín-Gallán P , Carrascosa A, Gussinyé M, Domínguez C.

Biomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complications. Varvarovská J , Racek J, Stozický F, Soucek J, Trefil L, Pomahacová R. Parameters of oxidative stress in children with Type 1 diabetes mellitus and their relatives.

J Diabetes Complications. Seghrouchni I , Drai J, Bannier E, Rivière J, Calmard P, Garcia I, Orgiazzi J, Revol A. Oxidative stress parameters in type I, type II and insulin-treated type 2 diabetes mellitus; insulin treatment efficiency.

Clin Chim Acta. VanderJagt DJ , Harrison JM, Ratliff DM, Hunsaker LA, Vander Jagt DL. Oxidative stress indices in IDDM subjects with and without long-term diabetic complications. Clin Biochem. Bonnefont-Rousselot D. Glucose and reactive oxygen species.

Ceriello A , Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Nishikawa T , Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP.

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Ramana KV , Chandra D, Srivastava S, Bhatnagar A, Srivastava SK.

Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells. FASEB J. Morré DM , Lenaz G, Morré DJ. Surface oxidase and oxidative stress propagation in aging. J Exp Biol. Shams N , Ianchulev T.

Role of vascular endothelial growth factor in ocular angiogenesis. Ophthalmol Clin North Am. Bhisitkul RB. Vascular endothelial growth factor biology: clinical implications for ocular treatments.

Br J Ophthalmol. Stitt AW. The role of advanced glycation in the pathogenesis of diabetic retinopathy. Exp Mol Pathol. Basta G , Schmidt AM, De Caterina R.

Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc Res. Nakamura Y , Horii Y, Nishino T, Shiiki H, Sakaguchi Y, Kagoshima T, Dohi K, Makita Z, Vlassara H, Bucala R. Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus.

Am J Pathol. Yamagishi S. Role of advanced glycation end products AGEs and receptor for AGEs RAGE in vascular damage in diabetes.

Yan SD , Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D, Stern D. Schmidt AM , Hori O, Chen JX, Li JF, Crandall J, Zhang J, Cao R, Yan SD, Brett J, Stern D. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 VCAM-1 in cultured human endothelial cells and in mice.

A potential mechanism for the accelerated vasculopathy of diabetes. Roebuck KA. Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB Review. Int J Mol Med. Hu FB , Stampfer MJ.

Is type 2 diabetes mellitus a vascular condition? Kaul K , Hodgkinson A, Tarr JM, Kohner EM, Chibber R. Is inflammation a common retinal-renal-nerve pathogenic link in diabetes? Curr Diabetes Rev. Esposito K , Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, Quagliaro L, Ceriello A, Giugliano D.

Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Lane N. A unifying view of ageing and disease: the double-agent theory.

J Theor Biol. Steinberg HO , Baron AD. Vascular function, insulin resistance and fatty acids. Lopes HF , Morrow JD, Stojiljkovic MP, Goodfriend TL, Egan BM.

Acute hyperlipidemia increases oxidative stress more in African Americans than in white Americans. Am J Hypertens. Stojiljkovic MP , Lopes HF, Zhang D, Morrow JD, Goodfriend TL, Egan BM.

Increasing plasma fatty acids elevates F2-isoprostanes in humans: implications for the cardiovascular risk factor cluster. Peelman F , Waelput W, Iserentant H, Lavens D, Eyckerman S, Zabeau L, Tavernier J.

Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases. Prog Lipid Res. Chan WB , Ma RC, Chan NN, Ng MC, Lee ZS, Lai CW, Tong PC, So WY, Chan JC. Increased leptin concentrations and lack of gender difference in Type 2 diabetic patients with nephropathy.

Diabetes Res Clin Pract. Wauters M , Considine RV, Yudkin JS, Peiffer F, De Leeuw I, Van Gaal LF. Leptin levels in type 2 diabetes: associations with measures of insulin resistance and insulin secretion. Horm Metab Res. Reilly MP , Iqbal N, Schutta M, Wolfe ML, Scally M, Localio AR, Rader DJ, Kimmel SE.

Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab. Yamagishi SI , Edelstein D, Du XL, Kaneda Y, Guzmán M, Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A.

Bouloumie A , Marumo T, Lafontan M, Busse R. Leptin induces oxidative stress in human endothelial cells. Yamamoto K , Völkl A, Hashimoto T, Fahimi HD. Catalase in guinea pig hepatocytes is localized in cytoplasm, nuclear matrix and peroxisomes. Eur J Cell Biol. Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies.

Zhang P , Liu B, Kang SW, Seo MS, Rhee SG, Obeid LM. Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl Galter D , Mihm S, Dröge W. Distinct effects of glutathione disulphide on the nuclear transcription factor kappa B and the activator protein Eur J Biochem.

Nguyen T , Sherratt PJ, Pickett CB. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element.

Annu Rev Pharmacol Toxicol. Thomas JA , Poland B, Honzatko R. Protein sulfhydryls and their role in the antioxidant function of protein S-thiolation. Arch Biochem Biophys. Shirwaikar A , Shirwaikar A, Rajendran K, Punitha IS.

In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine. Biol Pharm Bull. Ulrich-Merzenich G , Zeitler H, Vetter H, Kraft K.

Synergy research: vitamins and secondary plant components in the maintenance of the redox-homeostasis and in cell signaling. Winterbourn CC , Hampton MB. Thiol chemistry and specificity in redox signaling. Blendea MC , Jacobs D, Stump CS, McFarlane SI, Ogrin C, Bahtyiar G, Stas S, Kumar P, Sha Q, Ferrario CM.

Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression. Matsuzawa-Nagata N , Takamura T, Ando H, Nakamura S, Kurita S, Misu H, Ota T, Yokoyama M, Honda M, Miyamoto K.

Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity. Kunitomo M , Yamaguchi Y, Kagota S, Otsubo K.

Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome.

J Pharmacol Sci. Paolisso G , Giugliano D. Oxidative stress and insulin action: is there a relationship? Rudich A , Kozlovsky N, Potashnik R, Bashan N. Oxidant stress reduces insulin responsiveness in 3T3-L1 adipocytes.

Am J Physiol. Maddux BA , See W, Lawrence JC, Goldfine AL, Goldfine ID, Evans JL. Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Gardner PR, Fridovich I.

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Diabetic cardiovascular disease induced by oxidative stress. Int J Mol Sci ; 16 10 : — Kietzmann T, Petry A, Shvetsova A, Gerhold JM, Görlach A.

The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system. Br J Pharmacol ; 12 : — Butler R, Morris AD, Belch JJ, Hill A, Struthers AD. Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension.

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Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov ; 10 6 : — Griendling KK, Sorescu D, Ushio-Fukai M.

NAD P H oxidase: role in cardiovascular biology and disease. Circ Res ; 86 5 : — Gray SP, Di Marco E, Okabe J, Szyndralewiez C, Heitz F, Montezano AC, de Haan JB, Koulis C, El-Osta A, Andrews KL, Chin-Dusting JP, Touyz RM, Wingler K, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation ; 18 : — Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature ; : Tejero J, Shiva S, Gladwin MT.

Sources of vascular nitric oxide and reactive oxygen species and their regulation. Physiol Rev ; 99 1 : — Engineer A, Saiyin T, Greco ER, Feng Q. Say NO to ROS: their roles in embryonic heart development and pathogenesis of congenital heart defects in maternal diabetes.

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Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and a-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions.

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Adipose tissue inflammation and oxidative stress: the ameliorative effects of vitamin D. Inflammation ; 40 5 : — Gerber PA, Rutter GA. The role of oxidative stress and hypoxia in pancreatic β-cell dysfunction in diabetes mellitus.

Antioxid Redox Signal ; 26 10 : — Drews G, Krippeit-Drews P, Düfer M. Oxidative stress and β-cell dysfunction. Pflugers Arch ; 4 : — Maechler P, Jornot L, Wollheim CB. Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic β cells. J Biol Chem ; 39 : — Robertson RP, Harmon J, Tran PO, Poitout V.

β-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes ; 53 Suppl 1 : S—S Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F. Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

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Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH 2 -terminal kinase. Kawamori D, Kaneto H, Nakatani Y, Matsuoka TA, Matsuhisa M, Hori M, Yamasaki Y. The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation.

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Preventing p38 MAPK-mediated MafA degradation ameliorates β-cell dysfunction under oxidative stress. Mol Endocrinol ; 27 7 : — Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A.

p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol ; 23 8 : — Gurzov EN, Eizirik DL. Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction.

Trends Cell Biol ; 21 7 : — Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M, Eizirik DL.

Inhibition of cytokine-induced NF-? B activation by adenovirus-mediated expression of a NF-? B superrepressor prevents β-cell apoptosis. Diabetes ; 50 10 : — Henriksen EJ, Diamond-Stanic MK, Marchionne EM.

Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radic Biol Med ; 51 5 : — Mahadev K, Motoshima H, Wu X, Ruddy JM, Arnold RS, Cheng G, Lambeth JD, Goldstein BJ.

The NAD P H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol ; 24 5 : — Archuleta TL, Lemieux AM, Saengsirisuwan V, Teachey MK, Lindborg KA, Kim JS, Henriksen EJ.

Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPK. Free Radic Biol Med ; 47 10 : — Stuart CA, Howell ME, Cartwright BM, McCurry MP, Lee ML, Ramsey MW, Stone MH.

Insulin resistance and muscle insulin receptor substrate-1 serine hyperphosphorylation. Physiol Rep ; 2 12 : e Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRSmediated inhibition of insulin receptor tyrosine kinase activity in TNF-a- and obesity-induced insulin resistance.

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Kholoud Bokhary oxidatife, Feda AljaserManal OxidativfHajera TabassumNootropic Stack Recommendations BakhshShatha AlhammadRawan AleyadhiFaisal OxidxtiveRoua Alsubki; Role of Oxidative Stdess and Disbetes of Diabetic Retinopathy Oxidativs Type 1 and Gut health education 2 Diabetes. Ophthalmic Res 11 August ; dtress 4 : — Gut health education Diabetic Healthy afterschool snacks DR Gut health education a sight-threatening complication of diabetes mellitus DM. Oxidative stress generated on account of hyperglycemic state may lead to retinal abnormalities including DR. Objectives: The aim of the study was to evaluate the status of antioxidant enzymes; superoxide dismutase SODand catalase CATin different stages of DR severity in subjects with type 1 DM T1DM and type 2 DM T2DM. Subjects with DM were divided into 2 subgroups based on DR severity mild-to-severe nonproliferative DR [NPDR] and proliferative DR [PDR]and serum glycated hemoglobin HbA1clipid profile, SOD, and CAT were estimated. Results: Both SOD and CAT levels were lower in diabetic subjects than nondiabetic controls. Open access. Submitted: oxidative stress and diabetes July Published: 22 May adn com customercare stresss. Gut health education diabetds is a group Fueling strategies for ultramarathon runners metabolic diseases oxidatie by hyperglycemia resulting from oxidative stress and diabetes of insulin action, insulin secretion or both [ 1 ]. Diabetes has taken place as one of the most important diseases worldwide, reaching epidemic proportions. Hyperglycemia in the course of diabetes usually leads to the development of microvascular complications, and diabetic patients are more prone to accelerated atherosclerotic macrovascular disease.

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