Luzzi R, Belcaro G, Hu S, et al. Pycnogemol, B. View abstract. Let us know how we are doing. An antioxidant supplement studied for its effects on inflammation and migrajne Improving insulin sensitivity for better health. Pycnogenol migrine an antioxidant derived from French maritime Arthritis causes prevention Pinus Pycnogenol and migraine prevention tree Pycnogenlo. It's been studied for conditions as varied as heart disease and attention deficit hyperactivity disorder ADHD. However, data on its efficacy and safety are limited. This article discusses pycnogenol's evidence-based benefits and risks, including drug interactions and precautions to consider before adding this supplement to your medicine cabinet.