Alpha-lipoic acid and joint health -
Takayanagi H, Oda H, Yamamoto S, Kawaguchi H, Tanaka S, Nishikawa T, Koshihara Y A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis. Biochem Biophys Res Commun — Lee CK, Lee EY, Chung SM, Mun SH, Yoo B, Moon HB Effects of disease-modifying antirheumatic drugs and antiinflammatory cytokines on human osteoclastogenesis through interaction with receptor activator of nuclear factor kappaB, osteoprotegerin, and receptor activator of nuclear factor kappaB ligand.
Nagamatsu M, Nickander KK, Schmelzer JD, Raya A, Wittrock DA, Tritschler H, Low PA Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy.
Marracci GH, Jones RE, McKeon GP, Bourdette DN Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis. J Neuroimmunol — Miyazawa K, Mori A, Okudaira H IL-6 synthesis by rheumatoid synoviocytes is autonomously upregulated at the transcriptional level.
J Allergy Clin Immunol S—S Bondeson J, Foxwell B, Brennan F, Feldmann M Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators. Firestein GS, Boyle DL, Yu C, Paine MM, Whisenand TD, Zvaifler NJ, Arend WP Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis.
Shin H, Kitajima I, Nakajima T, Shao Q, Tokioka T, Takasaki I, Hanyu N, Kubo T, Maruyama I Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts. Aupperle KR, Bennett BL, Boyle DL, Tak PP, Manning AM, Firestein GS NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes.
Choy EH, Panayi GS Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med — Weinblatt ME, Kremer JM, Bankhurst AD, Bulpitt KJ, Fleischmann RM, Fox RI, Jackson CG, Lange M, Burge DJ A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate.
Dinarello CA The role of the interleukinreceptor antagonist in blocking inflammation mediated by interleukin Choy EH, Isenberg DA, Garrood T, Farrow S, Ioannou Y, Bird H, Cheung N, Williams B, Hazleman B, Price R, Yoshizaki K, Nishimoto N, Kishimoto T, Panayi GS Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial.
Abramson SB, Amin A Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage. Rheumatology Oxford — Article CAS Google Scholar. Kakimoto K, Kojima Y, Ishii K, Onoue K, Maeda H The suppressive effect of gelatin-conjugated superoxide dismutase on disease development and severity of collagen-induced arthritis in mice.
Clin Exp Immunol — Shingu M, Takahashi S, Ito M, Hamamatu N, Suenaga Y, Ichibangase Y, Nobunaga M Anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis in rats.
Download references. This work was supported by institutional grant from Asan Institute for Life Science , Seoul, Korea. We thank S.
Park and S. Lee Division of Nephrology, Department of Internal Medicine, Asan Medical Center, Seoul, Korea for the technical support on EMSA. We are grateful to J. Kim Asan Institute for Life Science, Seoul, Korea for animal care.
Division of Allergy and Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Pungnap-Dong, Songpa-Gu, Seoul, , Republic of Korea. Division of Endocrinology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. Asan Institute for Life Science, Seoul, Republic of Korea.
You can also search for this author in PubMed Google Scholar. Correspondence to Bin Yoo. Reprints and permissions. Lee, E. et al.
Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice. Rheumatol Int 27 , — Download citation. Received : 02 November Accepted : 24 July Published : 31 August Issue Date : January Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Objective To test the ability of alpha-lipoic acid LA to attenuate the development of collagen-induced arthritis CIA in mice.
In addition, research suggests that lipoic acid might be useful in those affected by multiple sclerosis. Researchers found that ALA improved a variety of inflammatory measures that are associated with the disease.
Increased instances of obesity in our society have encouraged interest in all kinds of weight-reducing approaches. ALA is a very useful addition to a weight loss program.
It may improve glucose and fat metabolism, which means that more sugars and fats in foods are broken down and used for energy rather than being stored as fat. Alpha Lipoic acid also prevents the production of chemerin, a molecule linked to obesity and metabolic syndrome. However, ALA will not replace eating healthy and remaining active.
Oxidative stress increases with aging and conditions such as diabetes, and it can have detrimental effects on vision.
As adults grow older, they become more vulnerable to developing cataracts, opacities of the lens that cloud sight. Alpha Lipoic acid was found to offer notable protection against cataract formation. Furthermore, a recent studies revealed that the combination of ALA and vitamin E helped prevent retinal cell death in animals with retinitis pigmentosa, an eye disease that also affects humans.
As there is currently no effective medical treatment for this vision-robbing disease, the discovery of a nutritional approach to potentially treat retinitis pigmentosa is amazing news!!! Macular degeneration is a type of blindness that occurs when the central portion of the retina starts to break down with age.
It is tightly connected to oxidation. ALA is not only a powerful antioxidant itself but it also regenerates other antioxidants. One of the antioxidants ALA recycles is vitamin E, which slows the progression of macular degeneration.
Alpha-lipoic acid has been shown to improve vision and slow the progression of macular degeneration. Mounting evidence suggests that ALA might have immunomodulatory effects on both the adaptive and innate immune systems by providing the necessary back-up support to all immune cells.
Migraines have been linked to mitochondrial dysfunction and oxidative stress. ALA is beneficial in both cases. In migraine sufferers alpha lipoic acid has shown the ability to reduce the frequency, duration, and intensity of migraines.
ALA also increases the efficacy of the migraine medication topiramate. According to the research, the combination of ALA and topiramate is significantly more effective than either drug alone in reducing the frequency and duration of migraines. ALA may also protect the body against toxic metal contaminants found in the environment and food supply.
It works by chelating these dangerous agents, such as arsenic, cadmium, lead, and mercury and rendering them inactive so that they can be removed by the body. In multiple studies alpha lipoic acid has been shown to provide protection against arsenic poisoning and to safeguard the liver against the effects of cadmium exposure.
Studies also revealed that lipoic acid helped protect the delicate nervous system against the harmful effects of mercury poisoning.
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Jint, it Alpha-lipoic acid and joint health Alpna-lipoic to be a universal gealth unique anti-oxidant because it is both Healty and water soluble. Alpha lipoic acid Alphs-lipoic a compound found naturally inside ojint cell in the body. It's Meal ideas for team sports by the body to produce the energy for our body's normal functions. Alpha lipoic acid is a substance that neutralizes potentially harmful chemicals called free radicals. The cells in our body are constantly battling free radical damage caused by toxins and other substances. Antioxidants, such as ALA, scavenge these free radicals and prevent cellular damage. We want to slow down cellular damage as much as possible, as it can cause inflammation and abnormal cells to grow and multiply, leading to diseases like cancer, heart disease, and diabetes. ABSTRACT: Alpha-lipoic acid Alpha-lippoic is known as a Quick vegetable snacks antioxidant with anti-inflammatory Craving control strategies. Also, recent studies have Quick vegetable snacks its joinnt effect on weight. However, studying the effects of Jojnt Alpha-lipoic acid and joint health Rheumatoid arthritis RA has been noticed rarely. Rheumatoid arthritis RA is an inflammatory disease often accompanied by functional disability, lower physical activity and consequent overweight. Therefore, we examined ALA effects on both clinical status and anthropometric indices in women with RA. Fasting blood samples were taken before and after the study to analyze serum rheumatoid factor RF and high sensitive C-reactive protein.Alpha-lipoic acid and joint health -
This study showed that ALA may have potential beneficial effects in RA patients. However, more comprehensive studies are needed to determine the effects of this promising antioxidant in RA. KEY WORDS: Alpha-lipoic acid, Clinical status, Disease activity score28, Rheumatoid arthritis, Rheumatoid factor, Weight.
Rheumatoid arthritis RA is an autoimmune chronic inflammatory disease causing swelling, tenderness and progressive destruction in joints Aletaha et al.
Immune cells involved in the pathogenesis of RA develop inflammation and oxidative stress in joints through excess production of molecules such as reactive oxygen species and inflammatory mediators Brennan et al. RA patients with inflamed damaged joints often experience different degrees of physical disability which could interfere with their routine activities Jung et al.
Limited physical activity is associated with overweight and obesity Liao et al. Given the existing positive feedback circle in which oxidative stress and inflammatory cytokine networks play role in pathogenesis of RA Firestein, ; Filippin et al.
In addition, taking into account the functional disability-associated obesity in RA patients, if an agent has also potential lowering effects on weight, it will be noteworthy to be studied as an adjuvant therapy in RA. Given the drug side effects Wood et al. Use this link to get back to this page.
ALA may play a role in the prevention and treatment of atherosclerosis artery hardening and related cardiovascular diseases. It increases nitric oxide-mediated vasodilation blood vessel widening and promotes anti-inflammatory and antithrombotic blood clot-reducing pathways.
ALA may also help prevent the development of hypertension high blood pressure by lowering the level of inflammatory cytokines in the blood and preventing pathological changes to blood vessel cells.
Our liver is responsible for essential functions such as removing toxins and supporting the digestive process. Nonalcoholic fatty liver disease NAFLD , a condition in which too much fat is stored in liver cells, has become the most common cause of chronic liver disease in the developed world and can be caused by obesity, type-2 diabetes, and poor diet.
If left untreated, it can lead to cirrhosis, or hardening of the liver. ALA has been shown to protect the liver in cases of NAFLD by reducing inflammation and oxidative damage in the liver.
ALA readily crosses the blood-brain barrier and is easily taken up by brain cells, where it neutralizes the damaging effects of oxidative stress and improves energy production in the brain, thereby supporting healthy brain aging, mental sharpness, and reducing the symptoms of dementia.
In addition, research suggests that lipoic acid might be useful in those affected by multiple sclerosis. Researchers found that ALA improved a variety of inflammatory measures that are associated with the disease.
Increased instances of obesity in our society have encouraged interest in all kinds of weight-reducing approaches.
ALA is a very useful addition to a weight loss program. It may improve glucose and fat metabolism, which means that more sugars and fats in foods are broken down and used for energy rather than being stored as fat.
Alpha Lipoic acid also prevents the production of chemerin, a molecule linked to obesity and metabolic syndrome. However, ALA will not replace eating healthy and remaining active. Oxidative stress increases with aging and conditions such as diabetes, and it can have detrimental effects on vision.
As adults grow older, they become more vulnerable to developing cataracts, opacities of the lens that cloud sight. Alpha Lipoic acid was found to offer notable protection against cataract formation. Furthermore, a recent studies revealed that the combination of ALA and vitamin E helped prevent retinal cell death in animals with retinitis pigmentosa, an eye disease that also affects humans.
As there is currently no effective medical treatment for this vision-robbing disease, the discovery of a nutritional approach to potentially treat retinitis pigmentosa is amazing news!!! Macular degeneration is a type of blindness that occurs when the central portion of the retina starts to break down with age.
It is tightly connected to oxidation. ALA is not only a powerful antioxidant itself but it also regenerates other antioxidants. One of the antioxidants ALA recycles is vitamin E, which slows the progression of macular degeneration. Alpha-lipoic acid has been shown to improve vision and slow the progression of macular degeneration.
Mounting evidence suggests that ALA might have immunomodulatory effects on both the adaptive and innate immune systems by providing the necessary back-up support to all immune cells.
Migraines have been linked to mitochondrial dysfunction and oxidative stress. Jaswal S, Mehta HC, Sood AK, Kaur J Antioxidant status in rheumatoid arthritis and role of antioxidant therapy. Clinica Chimica Acta , Malemud CJ Intracellular signaling pathways in rheumatoid arthritis.
Journal of Clinical and Cellular Immunology 4, Miossec P and Tebib J Diagnosis of rheumatoid arthritis at an early stage. In: Bouysset M, Tourne Y, Tillmann K eds. Foot and Ankle in Rheumatoid Arthritis, Berlin, Springer-Verlag, p Mirshafiey A and Mohsenzadegan M The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.
Iranian Journal of Allergy, Asthma and Immunology 4, Mirtaheri E, Gargari BP, Kolahi S, Dehghan P, Asghari-Jafarabadi M, Hajalilou M, Novin ZS, Abbasi MM Effects of alpha lipoic acid supplemetation on inflammatory biomarkers and matrix metalloproteinase-3 in rheumatoid arthritis patiens.
Journal of the American College of Nutrition 34, Mor A, Abramson SB, Pillinger MH The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction.
Clinical Immunology , Orhan CE, Onal A, Uyanikgil Y, Ulker S Antihyperalgesic and antiallodynic effect of sirolimus in rat model of adjuvant arthritis. European Journal of Pharmacology , Saxena R Arthritis as a disease of aging and changes in antioxidant status.
In: Preedy VR ed. Aging: Oxidative Stress and Dietary Antioxidants, London, Academic Press, p Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Biochimica et Biophysica Acta BBA -General Subjects , Snekhalatha U, Anburajan M, Venkatraman B, Menaka M Zeitschrift für Rheumatologie 4, Stadtman ER and Berlett BS Reactive oxygen-mediated protein oxidation in aging and disease. In: Gilbert DL and Colton CA eds.
Reactive Oxygen Species in Biology Systems: An Interdisciplinary Approach, New York, Kluwer Academic Publishers, p Wahl K and Schuna AA Rheumatoid arthritis. In: Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM eds.
Pharmacotherapy: A Pathophysiologic Approach, New York, Mc Graw Hill, p Waldburger J and Firestein GS Signaling pathways in rheumatoid arthritis.
In: Tak P ed.
Berry Tarts and Pies test the ability of ioint acid Heaoth to Balanced food portioning the development Balanced food portioning collagen-induced arthritis CIA in mice. Clinical, histologic, and qcid parameters were assessed. Human synovial fibroblasts and peripheral Alpha-liooic mononuclear cells were cocultured in various concentrations of LA to evaluate the effects on osteoclastogenesis. LA was associated with a dose-dependent reduction of CIA, as well as preventing bone erosion and destructive changes. Intracellular reactive oxygen species in lymphocytes obtained from inguinal lymph nodes, which was significantly higher in CIA than control mice, was significantly reduced in CIA by LA.
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