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How to Detox and Cleanse Your Lungs with Turmeric ❓Curcumin and Lung Health -
It is important to note that materials often referred to as curcumin are not identical to the pure, single-chemical entity. Because of the deficiency in the adequate chemical characterization of the immense diversity of crude turmeric T , extracts CE , enriched materials CTE, CEM , and even materials considered pure , augmented by the fact that the materials often share the same name curcumin , the usefulness of the biological data acquired from the plethora of these preparations is questionable.
This summary refers to all turmeric-derived intervention materials by using the collective term, curcumin-containing products. Tables at the end of each section specify the exact intervention material used in each cited study.
Extensive research over the past two decades suggests that curcuminoids belonging to the diferuloylmethane class of natural products, the major constituents in turmeric Curcuma longa , interfere with multiple cell signaling pathways, which provides support for the potential role of curcumin in modulating carcinogenesis.
These pathways include the following:[ 1 - 12 ]. Because of the abundance of in vitro and preclinical studies in the past two decades, there has been a significant increase in the number of clinical trials investigating the therapeutic potential of curcumin-containing products.
These clinical trials have used varying formulations and doses of curcuminoids for the prevention and treatment of cancer and to ameliorate symptoms of cancer treatment.
This summary will focus on the bioavailability , safety, and effectiveness of curcumin-containing products reported in clinical trials that targeted individuals at high risk of cancer and cancer patients for the prevention and treatment of cancer and ameliorating the symptoms of cancer treatment.
At least six phase I clinical trials of curcumin -containing products have investigated the pharmacokinetics and pharmacodynamics of pure curcumin CUR alone in humans. These concentrations refer to total curcumin , meaning that studies do not differentiate between free unconjugated curcumin and curcumin conjugated with glucuronic acid or sulfate.
Conjugated curcumin is the more abundant metabolite in circulation. While studies indicate that conjugated curcumin is less bioactive than free curcumin, there are also indications for the enzymatic release of free curcumin from the conjugated forms at sites of inflammation.
The assessment of curcuminoid bioavailability , including that of CUR, is confounded by the pronounced metabolic and photo chemical instability of these compounds. The general consensus that the plasma levels of CUR required to achieve any biological effects in patients are much higher than what has been observed clinically to date.
Studies have directly compared the bioavailability of unformulated curcumin-containing preparations with CUR that is formulated for enhanced bioavailability. These studies have consistently shown an increase in plasma levels using formulated CUR; however, these levels are still relatively low and do not exceed therapeutically insufficient concentrations.
Investigations into products that may aid in the prevention of cancer and the treatment of precancerous lesions are important for the development of early intervention strategies and treatments. A few studies have investigated the potential clinical benefit of curcumin -containing products, and other studies are under way.
See ClinicalTrials. Published results curcumin-containing product for prevention of colon cancer :. Treatment of patients with oral leukoplakia using a curcumin-containing product was investigated in a randomized trial.
Published results curcumin-containing product to treat oral leukoplakia :. The effect of a curcumin-containing product was investigated in patients with monoclonal gammopathy of undetermined significance MGUS or smoldering multiple myeloma SMM.
Published results effectiveness of curcumin-containing product on MGUS and SMM :. The efficacy and safety of curcumin-containing products have been studied in patients with nonalcoholic fatty liver disease NAFLD. Published results effectiveness of curcumin-containing product on NAFLD :.
Based on these findings, the authors suggested that curcumin-containing products, at higher dosages, might have a favorable effect on patients with NAFLD. Biomarkers have long been used to identify and understand the etiology of various diseases. In cancer research, there are different types of cancer biomarkers.
Prognostic biomarkers determine the likely outcome of the disease and if further treatment is warranted and predictive biomarkers ascertain the likelihood the disease will respond to treatment.
Five clinical studies have been performed to evaluate the effects of supplementation with curcumin -containing products on predictive biomarkers in patients with different types of cancer. Various biomarkers from these studies were evaluated as potential efficacy measures to ascertain the usefulness of curcumin-containing products alone and as an adjunctive therapy.
Different curcumin-containing products were used. The main biomarkers used in these studies were serum levels of the following:. Results from four of the studies indicated an association between a positive change in a biomarker and patient outcome as follows:.
However, another study found no statistically significant difference between comparison groups when accounting for the observed biomarker, PGE2. Two studies have been published that suggest a possible antitumor effect of curcumin-containing products.
Published results possible antitumor effect of curcumin-containing product :. Imatinib and curcumin-containing products have been studied in patients with metastatic adenoid cystic carcinoma ACC.
Published results treatment of c-kit —positive metastatic ACC with imatinib and a curcumin-containing product :. Two studies have explored the efficacy, tolerability, and feasibility of docetaxel plus curcumin-containing products in the treatment of cancer.
Published results efficacy of docetaxel and a curcumin-containing product :. A multicenter, phase II, randomized, double-blind study was initiated at the same institution in France and compared docetaxel plus a curcumin-containing product with docetaxel plus placebo in the first-line treatment of patients with metastatic castration-resistant prostate cancer.
The study was terminated for futility in view of results from the interim analysis NCT Three studies investigated the efficacy and safety of variable formulations and doses of curcumin-containing products in combination with gemcitabine.
Two research studies of first-line treatment in patients with advanced and metastatic pancreatic cancer PC showed differing results in tolerability and toxicity profiles.
The authors concluded that this combination of curcumin-containing products and gemcitabine is not feasible in this population of patients. A group from the United Kingdom conducted a combined phase I dose-escalation study and a phase IIA study of oral daily curcumin-containing products with folinic acid , fluorouracil , and oxaliplatin FOLFOX CUFOX in patients with metastatic colorectal cancer to assess safety, tolerability, and a suitable dose of curcumin.
Curcuminoids were prepared with phosphatidylcholine to boost bioavailability. This study reported an overall increase in self-reported QOL in both groups, with greater improvement in the curcuminoid group.
However, because of the higher baseline QOL values in the placebo group when compared with the curcuminoid group, it is difficult to interpret these results. The effects of curcumin -containing products on radiation-induced dermatitis were investigated in three studies.
Published results curcumin-containing products in the treatment of radiation-induced dermatitis :. Several studies evaluated the tolerability and efficacy of a curcuminoid-containing product by oral application mouthwash in the treatment of oral mucositis.
Published results curcuminoid-containing products in the treatment of oral mucositis :. These groups were further divided into experimental and control groups, with 40 patients in each subgroup receiving Meriva or a comparable placebo tablet. In both the chemotherapy and radiation therapy groups, frequency and severity of reported symptoms were significantly lower in the Meriva group and no significant changes were reported in the control group.
A case report has been published that suggests a possible antitumor effect of a curcumin-containing product. The case report described a 6 month-old infant with infantile hemangioendothelioma. Given that this disease is known to frequently undergo spontaneous involution, the therapeutic activity of the curcumin-containing product in this case should be questioned.
One pediatric study evaluated the tolerability and efficacy of a curcuminoid-containing product by oral application mouthwash in the treatment of oral mucositis. Seven patients four evaluable used 10 drops of Curcumall in 50 mL of water along with standard oral care 0.
Curcumall is a liquid formula mouthwash containing a tincture of curcumin C3 complex, turmeric, and ginger dissolved in glycerin and 0. Compliance was inconsistent as follows:[ 40 ].
Most clinical studies of curcuma-containing products have demonstrated few, if any, associated adverse effects. Two other patients had a dose reduction to 4, mg , also because of abdominal complaints. To assist readers in evaluating the results of human studies of integrative, alternative, and complementary therapies for cancer , the strength of the evidence i.
To qualify for a level of evidence analysis , a study must:. Separate levels of evidence scores are assigned to qualifying human studies on the basis of statistical strength of the study design and scientific strength of the treatment outcomes i.
The resulting two scores are then combined to produce an overall score. For an explanation of the scores and additional information about levels of evidence analysis of CAM treatments for cancer, see Levels of Evidence for Human Studies of Integrative, Alternative, and Complementary Therapies.
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available.
This section describes the latest changes made to this summary as of the date above. Added Pediatric Population and Curcumin-Containing Products as a new subsection.
This summary is written and maintained by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board , which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH.
More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® Cancer Information for Health Professionals pages. This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the use of curcumin in the treatment of people with cancer..
It is intended as a resource to inform and assist clinicians in the care of their patients. It does not provide formal guidelines or recommendations for making health care decisions. This summary is reviewed regularly and updated as necessary by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board , which is editorially independent of the National Cancer Institute NCI.
The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health NIH. Board members review recently published articles each month to determine whether an article should:.
Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary. Any comments or questions about the summary content should be submitted to Cancer.
gov through the NCI website's Email Us. Do not contact the individual Board Members with questions or comments about the summaries. Board members will not respond to individual inquiries. Some of the reference citations in this summary are accompanied by a level-of-evidence designation.
These designations are intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches. The PDQ Integrative, Alternative, and Complementary Therapies Editorial Board uses a formal evidence ranking system in developing its level-of-evidence designations.
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PDQ Curcumin Curcuma, Turmeric and Cancer. Bethesda, MD: National Cancer Institute. Permission to use images outside the context of PDQ information must be obtained from the owner s and cannot be granted by the National Cancer Institute.
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gov website can be found on our Contact Us for Help page. Questions can also be submitted to Cancer. Curcumin diarylheptanoid is one member of a group of natural compounds called curcuminoids, derived from the rhizome of Curcuma longa , an East Indian plant, contained in an extract commonly called turmeric.
Turmeric has a long history of therapeutic application in traditional Asian medicine. Extensive research over the past two decades suggests that curcuminoids, the active ingredient in turmeric C.
longa , interfere with multiple cell signaling pathways, providing support for the potential role of curcumin in modulating cancer development and progression.
With varying formulations and doses tested in phase I clinical trials , there is evidence of bioavailability of curcumin and curcumin conjugates in plasma , urine , and tissue. Results from early-phase trials of curcumin-containing products in the chemoprevention of colon , oral , and hepatic carcinoma appear promising.
However, the findings from these early trials have to be confirmed in well-powered trials evaluating safety and effectiveness as indicated by modulation of clinical outcomes.
Data from early-phase trials of the safety and effectiveness of curcumin-containing products in cancer treatment are at most from pilot trials that targeted various stages of cancer and cancer patient populations, and utilized different formulations and doses of curcumin and durations of intervention.
Thus, the evidence is currently inadequate to recommend curcumin-containing products for the treatment of cancer. Data from early-phase trials of the safety and effectiveness of curcumin-containing products as adjuncts to traditional cancer therapies are from pilot trials that had small sample sizes, targeted various stages of cancer and cancer patient populations, and utilized different formulations and doses of curcumin and durations of intervention.
Thus, the evidence is currently inadequate to recommend curcumin-containing products to be used as adjuncts for the treatment of cancer. Data from early-phase trials on the use of curcumin formulations to ameliorate cancer treatment—related effects have demonstrated a improved oxidative status in patients who received chemotherapy and radiation therapy , b delayed onset and severity of mucositis , c reduced severity of radiation dermatitis and d improved quality of life , without adverse effects with curcumin-containing products at these doses.
However, these studies were short in duration and used varying doses and formulations of curcumin. Thus, these results should be interpreted with caution. The findings from these early trials have to be confirmed in well-powered trials evaluating safety or effectiveness. In This Section Categories of Curcumin-type Products Curcumin is a member of the diarylheptanoid class of natural products curcuminoids derived from the rhizome of Curcuma longa L.
Categories of Curcumin-type Products The materials that have received the moniker curcumin may be divided into five categories: Turmeric T : Raw C. longa rhizomes. Turmeric extract TE : A solvent extract of dried or fresh C.
Curcuminoids-enriched turmeric extract CTE : Typically the deep-yellow precipitate collected from the solvent extract upon concentration under reduced temperature. Curcuminoids-enriched material CEM : Obtained by additional, often large-scale, chromatographic purification of CTE.
These pathways include the following:[ 1 - 12 ] Cell cycle cyclin D1 and cyclin E. Apoptosis activation of caspases and down-regulation of antiapoptotic gene products. Proliferation human epidermal growth factor receptor-2 [HER-2], epidermal growth factor receptor [EGFR], and activating protein-1 [AP-1].
Angiogenesis vascular endothelial growth factor [VEGF]. Metastasis CXC-chemokine receptor-4 [CXCR-4]. Inflammation nuclear factor-kappa B [NF-kappa B], tumor necrosis factor [TNF], interleukin- 1 [IL-1], interleukin-8 [IL-8], interleukin [IL], cyclooxygenase-2 [COX-2], and 5-lipoxygenase [5-LOX].
In This Section Bioavailability of Curcumin-Containing Products Phase I Clinical Trials Cancer Prevention and Treatment of Precancerous Lesions Colorectal cancer Head and neck cancer Multiple myeloma Hepatoma liver cancer Cancer Treatment Biomarker studies Curcumin-containing products alone Imatinib and curcumin-containing products Docetaxel and curcumin-containing products Gemcitabine and curcumin-containing products FOLFOX and curcumin-containing products Quality-of-Life Studies Cancer Therapy Side Effects Dermatitis Mucositis Multiple effects Pediatric Population and Curcumin-Containing Products Anticancer effects Mucositis Bioavailability of Curcumin-Containing Products Phase I Clinical Trials At least six phase I clinical trials of curcumin -containing products have investigated the pharmacokinetics and pharmacodynamics of pure curcumin CUR alone in humans.
As previously mentioned, by successfully reducing inflammation in the body, you can indirectly support lung health and improve respiratory function. Incorporating spices into your diet is a natural and delicious way to reduce inflammation and support overall lung health. From cinnamon and cayenne pepper to ginger, thyme, and alfalfa, these spices offer numerous health benefits, including:.
Read our full guide on the best foods for lung health if you want to dive deeper into this topic. John Landry is a registered respiratory therapist from Memphis, TN, and has a bachelor's degree in kinesiology.
He enjoys using evidence-based research to help others breathe easier and live a healthier life. Top 10 Spices That Reduce Inflammation in the Lungs by John Landry, BS, RRT Updated: Feb 14, Did you know that certain spices have powerful anti-inflammatory properties?
What is Inflammation? Best Spices for Reducing Inflammation in the Lungs Turmeric Cinnamon Ginger Garlic Onion Chili Pepper Cayenne Pepper Thyme Oregano Alfalfa 1. Turmeric Turmeric is a popular spice well-known for its potent antioxidant and anti-inflammatory effects.
Our Top Pick. Purality Health® Liposomal Turmeric. This turmeric product provides better nutrient absorption to help you get more of the benefits.
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Written by:. John Landry, BS, RRT. References Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Rao PV, Gan SH. Cinnamon: a multifaceted medicinal plant.
Evid Based Complement Alternat Med. doi: Epub Townsend EA, Zhang Y, Xu C, Wakita R, Emala CW. Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. Am J Respir Cell Mol Biol.
Semwal RB, Semwal DK, Combrinck S, Viljoen AM. Gingerols and shogaols: Important nutraceutical principles from ginger. Bayan L, Koulivand PH, Gorji A. Garlic: a review of potential therapeutic effects.
Avicenna J Phytomed. PMID: ; PMCID: PMC White D. Healthy Uses for Garlic. Nurs Clin North Am. PMID: Jin ZY, Wu M, Han RQ, Zhang XF, Wang XS, Liu AM, Zhou JY, Lu QY, Zhang ZF, Zhao JK.
Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population. Cancer Prev Res Phila. Beigoli S, Behrouz S, Memar Zia A, Ghasemi SZ, Boskabady M, Marefati N, Kianian F, Khazdair MR, El-Seedi H, Boskabady MH.
Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence. Chang A, Rosani A, Quick J. In: StatPearls [Internet]. Treasure Island FL : StatPearls Publishing; Jan. Lindberg S, Mercke U. Capsaicin stimulates mucociliary activity by releasing substance P and acetylcholine.
Eur J Respir Dis. Sandoiu, A. Chili pepper compound may slow down lung cancer. Sarabon N, Löfler S, Cvecka J, Hübl W, Zampieri S. Acute effect of different concentrations of cayenne pepper cataplasm on sensory-motor functions and serum levels of inflammation-related biomarkers in healthy subjects.
Eur J Transl Myol. Fachini-Queiroz FC, Kummer R, Estevão-Silva CF, Carvalho MD, Cunha JM, Grespan R, Bersani-Amado CA, Cuman RK.
Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response. Hammoudi Halat D, Krayem M, Khaled S, Younes S. A Focused Insight into Thyme: Biological, Chemical, and Therapeutic Properties of an Indigenous Mediterranean Herb.
Raeeszadeh M, Beheshtipour J, Jamali R, Akbari A.
Lunv may have heard about ad amazing benefits Post-workout nutrition advice turmeric. Cufcumin is a powerful anti-inflammatory herb that Curcumin and Lung Health Curcumih health Anti-wrinkle treatment, and Curcummin herbal supplement that is rapidly growing in popularity Develop laser focus research continues to unveil its unique medicinal properties. One of the lesser known benefits of turmeric is that it has a positive effect on lung health. Turmeric is a plant in the ginger family Zingiberaceaenative to Southeast Asia where it is grown commercially. The rhizome underground stem of the turmeric plant is used as a culinary spice and also as a traditional medicine.
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