Gut health and longevity -
A healthy gut microbiome helps in the digestion and absorption of nutrients from food, ensuring that your body receives the necessary vitamins and minerals for proper functioning.
With age, nutrient absorption can decline , leading to deficiencies that contribute to various health problems. A healthy gut microbiome aids in the efficient extraction of nutrients, promoting better overall health and longevity.
Therefore, a balanced and diverse gut microbiome contributes to a well-regulated immune response. As you age, immune function tends to decline , and any dysbiosis, or imbalance in the gut microbiome, may contribute to age-related immune dysfunction.
Chronic, low-grade inflammation is associated with various age-related diseases. A balanced gut microbiome helps regulate the immune system see above and prevents chronic inflammation.
Imbalances, on the other hand, can contribute to the development of conditions such as cardiovascular disease, diabetes, and neurodegenerative disorders.
Chronic inflammation represents a significant risk factor for morbidity and mortality in the elderly. The gut-brain axis is a bidirectional communication system between the gut and the brain. Emerging research suggests that the gut microbiome may influence cognitive function and may play a role in age-related cognitive decline and neurodegenerative diseases.
A healthy gut contributes to better mental well-being and cognitive longevity. Maintaining a diverse and healthy gut microbiome may positively influence your metabolism and weight regulation, which can contribute to overall health and longevity. Beneficial bacterial strains such as Akkermansia muciniphila have been associated with supporting GLP-1 production, a hormone produced in the gut that triggers a host of downstream metabolic effects including reducing appetite, helping to release insulin, and supporting a healthy weight.
Conversely, low levels of beneficial bacteria have been linked to metabolic disorders and obesity. Gut bacteria such as Anaerobutyricum hallii , Clostridium butyricum , and Clostridium beijerinckii can produce bioactive compounds such as short-chain fatty acids SCFAs , which have been associated with various health benefits.
SCFAs, for example, may contribute to the maintenance of intestinal health and have systemic effects on metabolism. Maintaining a healthy gut microbiome is crucial for proper digestion and can help prevent issues such as constipation, diarrhea, and other gastrointestinal problems that can increase and impact the quality of life as you age.
Nathan Price, co-corresponding author of the paper. This research project was conducted by ISB and collaborators from Oregon Health and Science University, University of California San Diego, University of Pittsburgh, University of California Davis, Lifestyle Medicine Institute, and University of Washington.
It was supported in part by a Catalyst Award in Healthy Longevity from the National Academy of Medicine, and the Longevity Consortium of the National Institute on Aging. Materials provided by Institute for Systems Biology.
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FULL STORY. RELATED TERMS Calorie restricted diet Hair Baldness treatments Scientific method Histamine Oily fish Jejunum Human position. Story Source: Materials provided by Institute for Systems Biology.
Journal Reference : Tomasz Wilmanski, Christian Diener, Noa Rappaport, Sushmita Patwardhan, Jack Wiedrick, Jodi Lapidus, John C.
Earls, Anat Zimmer, Gustavo Glusman, Max Robinson, James T. Yurkovich, Deborah M. Kado, Jane A. Cauley, Joseph Zmuda, Nancy E.
Lane, Andrew T. Magis, Jennifer C. Lovejoy, Leroy Hood, Sean M. Gibbons, Eric S. Orwoll, Nathan D. Gut microbiome pattern reflects healthy ageing and predicts survival in humans.
Nature Metabolism , Feb. Cite This Page : MLA APA Chicago Institute for Systems Biology. ScienceDaily, 18 February Institute for Systems Biology. Although the impact of gut dysbiosis on chronic disease appears to be limited, gut health is important for other aspects of human health.
For example, the microbiota prevents other harmful bacteria from colonizing our gut. In addition, it allows us to digest certain nutrients e. dietary fibre that would otherwise be rejected by our bodies.
Therapies that modulate the gut microbiota have recently been approved by U. health authorities for the prevention of C. difficile infections a bacterium that causes diarrhea and other serious intestinal diseases. Our results, along with results from clinical studies less prone to reverse causality and confounding bias, do not, however, support a significant effect of gut dysbiosis on chronic disease.
These results support the conclusion that the potential of the microbiota as a therapeutic target for chronic diseases is, at present, low.
We urge health professionals and the general public to be cautious about diagnostic tests based on gut microbiota to diagnose health problems that are not validated by the relevant health authorities. Most importantly, we urge health professionals to avoid recommending specific interventions based on the mere fact that they would influence the parameters of the gut microbiota.
This article was originally published in French. Menu Close Home Edition Africa Australia Brasil Canada Canada français España Europe France Global Indonesia New Zealand United Kingdom United States.
Edition: Available editions Europe. Become an author Sign up as a reader Sign in. Certain factors can disrupt the gut microbiota. These include our diet, alcohol consumption, antibiotics and inflammatory bowel disease.
Éloi Gagnon , Benoit Arsenault , Université Laval. Genetics Bacteria Life expectancy Chronic diseases Weight loss Gut microbiome Mutations Eating habits Physiology Health Healthy eating Viruses Alcohol consumption Longevity Microbiota Weight Genetic research.
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