Restrictoins Health hazards of severe dietary restrictions. Schreiber, K. O'Flanagan, C. Actions for this page Listen Print. Caloric restriction modulates the monoaminergic and glutamatergic systems in the hippocampus, and attenuates age-dependent spatial memory decline. Calorie restriction xevere restriction or energy restriction is a dietary regimen that reduces the energy intake Harmony foods and beverages segere incurring malnutrition. Caloric intake zevere, Low carb diet reduction Hralth overweight individuals, Apple cider vinegar for arthritis hazatds by Restrictikns dietary guidelines restrichions science-based societies. The term "calorie restriction" as Health hazards of severe dietary restrictions in the study of aging refers to dietary regimens that reduce calorie intake without incurring malnutrition. The experiment also caused negative effects, such as anemiaedemamuscle wastingweaknessdizzinessirritabilitylethargyand depression. Typical low-calorie diets may not supply sufficient nutrient intake that is typically included in a calorie restriction diet. People losing weight during calorie restriction risk developing side effectssuch as cold sensitivitymenstrual irregularitiesinfertilityor hormonal changes. As ofintermittent fasting and calorie restriction remain under preliminary research to assess the possible effects on disease burden and increased lifespan during aging, although the relative risks associated with long-term fasting or calorie restriction remain undetermined.