Probiotics for liver health -
Finally, a healthy gut microbiota allows the normal production of butyrate by intestinal bacteria which helps in the maintenance of gut barrier integrity. Probiotics for other uses than food and dietary supplements also showed promising results in the management of liver disease, such as Alcoholic Liver Disease ALD and Non-Alcoholic Fatty Liver Diseases NAFLD.
The intake of probiotic has been demonstrated to modify the gut microflora and ameliorate liver parameters among ALD patients [ Han, ; Suk ]. Clinical studies in children with NAFLD taking medical probiotics that are not food or dietary supplements also showed improvement in liver parameters and symptoms of NAFLD, as well as improvement in total body fat and BMI [Yang, ; Cakir, ].
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PLoS ONE 13 , e Negi, C. Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease. Download references. The authors would like to extend their sincere appreciation to The Science, Technology and Innovation Funding Authority STDF and the Egyptian Knowledge Bank EKB.
Genetics and Genetic Engineering, Department of Animal Wealth Development, Faculty of Veterinary Medicine, Benha University, Banha, Egypt. Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P. Box , Riyadh, , Saudi Arabia. Biochemistry Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt.
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Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. Skip to main content Thank you for visiting nature. nature scientific reports articles article. Download PDF. Subjects Biochemistry Molecular biology Physiology. Introduction The percentage of nonalcoholic fatty liver disease NAFLD patients who also have nonalcoholic steatohepatitis NASH is expected to increase during the coming ten years.
Material and methods The current study was approved by the Ethical Committee for live birds sampling at the Faculty of Veterinary Medicine, Benha University BUFVTM Rabbits The current study was carried out in the Faculty of Veterinary Medicine, Benha University, Department of Animal Wealth Development, using 45 male New Zealand white rabbits eight weeks old, about g body weight.
The experimental design The rabbits were weighed individually and marked. The three groups were as follows: Group I received the basal diet. Table 1 Ingredients and nutritional composition of basal diet. Full size table. Table 2 Ingredients and nutritional composition of HCD. Table 3 Primers used for qRT-PCR.
Result Concerning histopathological changes in liver sections from control rabbits, they showed the liver's typical histological structure, which was made up of hepatic lobules with radiating hepatocytes surrounding a central vein and irregular blood sinusoids separating them Fig. Figure 1.
Full size image. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Figure 8. Figure 9. Figure Effect of HCD supplementation and HCD with probiotic on liver function Glucose.
Effect of HCD supplementation and HCD with probiotic on liver function Total bilirubin. Discussion The HCD-supplemented group's liver sections showed significant hepatic vacuolation along with fat cytoplasmic vacuoles. Conclusion Many of the physiopathological characteristics of NAFLD were shared by cholesterol-fed rabbits.
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The beneficial impacts of probiotics as new promising therapeutic agents for patients with NAFLD have been summarized in this studies. Convincing evidence was obtained regarding associations between probiotic intake and liver function improvement reflecting as the serum levels of ALT, AST, and GGT.
However, due to the high heterogeneity of the results and the small number of studies included in each subgroup, the outcomes of the present study should be interpreted with caution.
Even though most studies showed hepatic enzymes as biomarkers for liver function, there is still no comprehensive agreement on counting on the enzyme levels in order to indicate liver function. Adding other non-invasive assessments in line with enzyme levels in RCTs seems to be a necessity.
Conclusively, further studies need to be conducted for a definite presumption. All the materials used in this systematic review and meta-analysis have been fully referenced.
VM and SA wrote the original manuscript and contributed to the conception of the article. VM and NR contributed to data collection and analyze and provided advice and consultation.
PD contributed to the final revision of the manuscript. All authors read and approved the final manuscript. The research protocol was approved and supported by the Student Research Committee, Tabriz University of Medical Sciences Registration code: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.
Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. NAFLD, Non-alcoholic fatty liver disease; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; GGT, Gamma-glutamyl transferase; NASH, Non-alcoholic hepatitis; MTTs, microbiome-targeted treatments; ES, effect sizes; CI, corresponding confidence intervals.
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RPobiotics Gastroenterology volume 22Article number: Cite this article. Metrics details. Healthh the increasing Traditional herbal medicine of Proobiotics fatty liver disease, it is necessary to find an easy Probiotics for liver health hdalth method Probiotics for liver health its management and treatment. Probiotics are a group of living microorganisms that might affect NAFLD through the intestinal-liver axis. The present clinical trial aims to examine the effect of probiotic yogurt consumption on liver enzymes, steatosis and liver fibrosis in patients with NAFLD. Sixty-eight patients with NAFLD will be recruited in this study. Weight, height, and waist circumference will be measured at study baseline and after the intervention.
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