Video
The REAL Reason Why Your Arteries are Calcifying and Turning into BoneAntioxidant and bone health -
Setting the record straight on bone health. Nutrition Action website. Published August 4, Sahni S, Mangano KM, McLean RR, Hannan MT, Kiel DP. Dietary approaches for bone health: lessons from the Framingham Osteoporosis Study.
Curr Osteoporosis Rep. Aghajanian P, Hall S, Wongworawat MD, Mohan S. The roles and mechanisms of actions of vitamin C in bone: new developments. J Bone Miner Res. Rao LG, Mackinnon ES, Josse RG, Murray TM, Strauss A, Rao AV.
Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women. Osteoporos Int. Mackinnon ES, Rao AV, Josse RG, Rao LG. Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telop eptide of type I collagen in postmenopausal women.
Mackinnon ES, Rao AV, Rao LG. Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women.
J Nutr Health Aging. Gunn CA, Weber JL, Kruger MC. Midlife women, bone health, vegetables, herbs and fruit study. The Scarborough Fair study protocol. BMC Public Health. Gunn CA, Weber JL, McGill AT, Kruger MC. Increased intake of selected vegetables, herbs and fruit may reduce bone turnover in post-menopausal women.
García-Martínez O, Rivas A, Ramos-Torrecillas J, De Luna-Bertos E, Ruiz C. The effect of olive oil on osteoporosis prevention.
Int J Food Sci Nutr. Melguizo-Rodríguez L, Manzano-Moreno FJ, Illescas-Montes R, et al. Bone protective effect of extra-virgin olive oil phenolic compounds by modulating osteoblast gene expression. Chen F, Du M, Blumberg JB, et al.
Association among dietary supplement use, nutrient intake, and mortality among U. adults: a cohort study. Ann Intern Med. Confirmation of all fractures was obtained from revision of x-rays.
All fractures except 1 1 wrist fracture in the control group were the result of significant trauma 2 motor vehicle accidents, 1 skiing trauma, and 1 fall from higher than standing height. As far as the BMI is concerned, even if no specific dietary assessment aimed at determining single antioxidant intake was made, all subjects were on a free diet and obtained a score Mean plasma levels of vitamin C, vitamin E, vitamin A, and uric acid were consistently lower in osteoporotics than in controls Table 2.
Despite this, none of the subjects belonging to the two groups had levels below the normal vitamin C and vitamin E ranges. This reinforces the assumption of adequate nutritional status in both groups, at least in terms of dietary antioxidants.
Also, the activities of antioxidant enzymes in plasma SOD and GPx and erythrocytes only SOD were significantly lower in osteoporotics than in controls Table 2. Adjustment for BMI and age did not alter differences between the two groups. On the other hand, MDA, a marker of lipid oxidative damage, did not show any significant difference between osteoporotic and control subjects Table 2.
Correlation between plasma antioxidant levels and femoral BMD in osteoporotic subjects. This study investigates a broad spectrum of plasma antioxidants in osteoporosis.
We found that a group of elderly osteoporotic women had consistently lower levels of all natural antioxidants tested than controls. This difference held significant across the whole panel of exogenous dietary vitamin A, vitamin C, and vitamin E and endogenous molecules uric acid, superoxide dismutase, and glutathione peroxidase with scavenging activity.
Taken in aggregate, these data seem to point to a negative role for antioxidant deficit in age-related bone loss. This is in keeping with prior evidence deriving both from some epidemiological studies that suggested that higher dietary antioxidant intake has a protective role on bone health 10 — 13 and from a single cohort study that found decreased activity of superoxide dismutase and glutathione peroxidase in postmenopausal osteoporotic women Data from various observational studies, albeit not consistently, seem to carve out a positive role for vitamin C in contrasting age-related bone loss of women in their early and midpostmenopausal years, especially if they were calcium repleted, but not estrogen repleted 10 , Furthermore, dietary intake of vitamin C and vitamin E has proven protective against hip fracture in a particular subset of female smokers selected from a large population of women followed prospectively for up to 5 yr In contrast, excess dietary retinol vitamin A intake has been recently recognized as a risk factor for hip fracture and has been associated with accelerated bone loss 27 — 32 This nutrient, according to some researchers, could provide a reasonable explanation for the higher incidence of osteoporotic fractures in Sweden and Norway, where the diet is particularly rich not only in calcium and vitamin D compared with the rest of Europe, but also in vitamin A, contained in cod liver oil, dairy products, and milk, usually fortified with vitamins A and D 27 , Our data seem to contrast with this view, in that we found lower levels of vitamin A in osteoporotics.
Moreover, vitamin A was the dietary antioxidant most strongly and positively correlated with bone mass in the osteoporotic population. Notwithstanding our results, it is tenable that very high levels of vitamin A exert a negative effect on bone, especially in light of the results of the Rancho Bernardo study This prospective investigation, indeed, not only suggests that supplemental retinol users are at increased risk of femoral neck bone loss, but also attributes a potential advantage in terms of bone mass retention to subjects with high vitamin A intake not deriving from supplements.
The researchers conclude by hinting at the existence of a delicate balance between ensuring adequate vitamin A intake and amplifying age-related bone loss due to excessive retinol supplementation. Any apparent discrepancy with inferences from the present investigation can be interpreted in light of the fact that subjects taking supplements were excluded from our study.
For any condition or disease in which a decrease in antioxidant defenses is demonstrated, the question has to be answered whether this is mainly due to an increased production of free radicals or to a poor dietary antioxidant intake.
When free radicals are produced in excess to the capacity of the body to neutralize them, a condition of oxidative stress takes place. Oxidative stress, defined as an imbalance between antioxidants and prooxidants in favor of the former, potentially leading to damage, generally implies that antioxidants are low and markers of oxidative damage are increased 33 , In this study we measured plasma MDA as a marker of free radical-mediated lipid peroxidation and found no difference between groups.
This finding contrasts with the results of a recent study, reporting increased levels of MDA in a limited sample of postmenopausal osteoporotic women However, in the latter study the osteoporotic subjects were compared with a smaller sample of healthy younger controls, therefore precluding the possibility of discriminating the effects of aging from those of osteoporosis.
Possible alternative explanations for the absence of an MDA increase in our osteoporotic subjects compared with controls are 1 the decrease in antioxidants in osteoporotic women reflects an increased production of reactive oxygen intermediates ROI , i.
free radicals, to such an extent that they are unable to generate high levels of MDA; 2 the decrease in antioxidants in osteoporotic women reflects an increased production of ROI, leading to the formation of oxidized biological molecules different from MDA e.
Although the first mechanism is purely speculative and is not substantiated by any evidence, the second one is at least in part supported by the results of a recent study that found a negative relationship between urinary levels of 8 iso-prostaglandin 2α and BMD MDA measurement, although performed by means of a reliable HPLC method, suffers from a number of limitations that might prevent its use as a marker of oxidative damage in osteoporotic subjects The third mechanism, i.
low dietary intake of antioxidants and metals, such as selenium, zinc, and copper, necessary for the activity of antioxidant enzymes, might also be supported by our data, because controls had higher BMI than osteoporotic subjects. Although all subjects were receiving a free diet, it is possible that the diet of osteoporotic women included a lower number of fruit and vegetable servings than that of controls and hence did not provide an adequate amount of antioxidants.
Whatever the cause of the low antioxidant levels, the results of this and previous studies suggest that antioxidant deficiency has a negative impact on bone mass.
Several potential mechanisms might underlie this relationship. For instance, nuclear factor-κB, which is known to mediate some of the important actions of TNFα, a cytokine synthesized in the bone microenvironment, on osteoclastogenesis, is activated in osteoblast-like cells by mitogens and cytokines through the generation of ROI 37 — In other words, intracellular free radical production might represent the final common mechanism of nuclear factor-κB activation by a variety of factors If this mechanism of action of osteoclastogenic cytokines satisfactorily fits most models of bone loss, it is conceivable that low intracellular and probably interstitial levels of antioxidants are a signal, i.
a consequence, of increased osteoclastogenic activity and bone turnover. Alternatively, it is also tenable that low levels of intracellular antioxidants may amplify osteoclastogenesis through uncontrolled availability of excess ROI. Not only might osteoclastic differentiation of bone precursors be modulated by ROI, but osteoblastic differentiation as well.
Mody et al. Quite recently, other evidence linking osteoporosis to increased oxidative stress has been produced, particularly for a severe osteoporotic syndrome in relatively young males A small 3.
Some important limitations of our study should be acknowledged. First, we did not measure dietary calcium. Different intakes in the two groups could have at least in part influenced BMD results, even because some of the positive effects of vitamin C on bone might not be realized in the absence of adequate calcium intake.
Secondly, we did not directly measure dietary whole caloric or single antioxidant intake. Although this potential bias was mitigated by the fact that all subjects were well nourished, there is a possibility that minor or selective nutritional deficits might be more represented in the osteoporotic group.
Thirdly, the results of our study may not apply to the general elderly population, because the frailest and oldest elders were not included. Finally, our study is limited by the fact that we did not verify any of the relationships between low levels of antioxidants and reduced BMD.
We conclude by suggesting that elderly osteoporotic women have lower antioxidant defenses compared with a normal age-matched reference population. is European Union Marie-Curie Fellow for the program Quality of Life and Management of Living Resources, project entitled Nutritional Health-Sustaining Factors and Determinants of Healthy Aging: Oxidative Stress-Related Biomarkers of Successful Aging and Age-Related Diseases.
Oeffinger KC Scurvy: more than historical relevance. Am Fam Physician 48 : — Google Scholar. Peterkofsky B Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy.
Am J Clin Nutr 54 : S—S. Sugimoto T , Nakada M , Fukase M , Imai Y , Kinoshita Y , Fujita T Effects of ascorbic acid on alkaline phosphatase activity and hormone responsiveness in the osteoblastic osteosarcoma cell line UMR Calcif Tissue Int 39 : — Aronow MA , Gerstenfeld LC , Owen TA , Tassinari MS , Stein GS , Lian JB Factors that promote progressive development of osteoblast phenotype in cultured fetal rat calvaria cells.
J Cell Physiol : — Owen TA , Aronow MA , Shalhoub V , Barone L , Wilming L , Tassinari MS , Kennedy MB , Packwinse S , Lian JB , Stein GS Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the one extracellular matrix.
Franceschi RT , Iyer BS Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J Bone Miner Res 7 : — Franceschi RT , Young J Regulation of alkaline phosphatase by 1,dihydroxyvitamin D 3 and ascorbic acid in bone-derived cells.
J Bone Miner Res 5 : — Dixon SJ , Wilson JX Transforming growth factor-β stimulates ascorbate transport activity in osteoblastic cells. Endocrinology : — Kipp DE , Grey CE , Mcelvain ME , Kimmel DB , Robinson RG , Lukert BP Long term low ascorbic acid intake reduces bone mass in guinea pigs.
J Nutr : — Hall SL , Greendale GA The relation of dietary Vitamin C intake to bone mineral density: results from the PEPI study. Calcif Tissue Int 63 : — Leveille SG , Lacroix AZ , Knepsell TD , Beresford SA , Van Belle G , Buchner GM Dietary vitamin C and bone mineral density in postmenopausal women in Washington state, USA.
J Epidemiol Commun Health 51 : — Wang MC , Luz Villa M , Marcus R , Kelsey JL Associations of vitamin C, calcium, and protein with bone mass in postmenopausal Mexican American women. Osteop Int 7 : — Melhus H , Michaelsson K , Holmberg L , Wolk A , Ljunghall S Smoking, antioxidant Vitamins, and the risk of hip fracture.
J Bone Miner Res 14 : — Viereck V , Grundker C , Blaschke S , Siggelkow H , Emons G , Hofbauer LC Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts. J Cell Biochem 84 : — Sierens J , Hartley JA , Campbell MJ , Leathem AJ , Woodside JV In vitro isoflavone supplementation reduces hydrogen peroxide-induced DNA damage in sperm.
Teratog Carcinog Mutagen 22 : — Sierens J , Hartley JA , Campbell MJ , Leathem AJ , Woodside JV Effect of phytoestrogen and antioxidant supplementation on oxidative DNA damage assessed using the comet assay. Mutat Res : — Am J Clin Nutr 72 : — Guygoz Y , Vellas BJ , Garry PJ Mini Nutritional assessment: a practical assessment tool for grading the nutritional status of elderly patients.
Fact Res Gerontol 4 Suppl 2 : 15 — Kutnink MA , Hawkes WC , Schaus EE , Omaye ST An internal standard method for the unattended high-performance liquid analysis of ascorbic acid in blood components.
Anal Biochem : — Nierenberg DW , Nann SL A method for determining concentrations of retinol, tocopherol, and five carotenoids in human plasma and tissue samples. Am J Clin Nutr 56 : — Methods Enzymol : — Winterbourn CC , Hawkins ER , Brian M , Carrell WR The estimation of red cell superoxide dismutase activity.
J Lab Clin Med 85 : — Ideally, we should be drinking 5 cups a day. Too many for me. JOYCE CORMACK. I drink one tea bag in 2 cups of water, hope to move up to one cup water to one teabag. Is loose tea that you brew any better than tea bags for these nutrients?
I get the loose tea for brewing. It is tastier and fresher. Cup for cup, kale is the king of calcium it contains three times more than spinach. The crimson veggie is a rich source of inulin, a carbohydrate that naturally enhances calcium absorption in the intestines, according to a recent study in the journal of lost in the paste.
I forgot to add that the loose tea I buy, the leaves are actually green in color. Leslie Ms. I Also Take Evening Primrose In A Soft Gel Form. NANCY RAIN.
This has helped very little and is costly to continue. Is going to try steroid injections next. Can you advise us on any treatment for the relief of pain. Thank you. Clara Mae Watrous. Hi Vivian, Very interesting about quercetin and the foods that are high in it.
I have a question. I want to get your program as soon as I gather some money to do so. Clara Mae. So stay tuned!
Hi, My question is what, if any, muli-vitamin is recommended. I purchased the SaveOurBones program last year, and am taking an AlgaeCal based calcium supplement, with D3, K2, etc.
But Vivian recommends many other Vitamins and minerals to take. I am no fan of a multivitamin. There is always too much vitamin A, the synthetic kind, in them. Vitamin A, the synthetic type, keeps us from absorbing D. We get so much A from our vegetables, natural A, and our body knows how to deal with it properly.
Dianne, I am not currently recommending any particular brand of multivitamin…but the Program does contain an extensive list of Foundation Supplements, so you should have all the information you need to choose a good one.
Nancy Pulecio. Dear Vivian, you are so wonderful sharing with all of us all your knowledge. There are not enough words to thank you. Every day when I look into your e-mail I feel you are like my doctor telling me what to do with my osteoporosis and I am sure that in a year since I started following your guidance I will be WELL!
Thanks always thanks!!! Today, February 20, , I read your latest suggestion for good bone health. You suggested that we use the antioxidant called, Quercetin.
Is it a new finding? This information simply underscores the healthful nature of the Save Our Bones diet. Yes, blueberries and cranberries are acidifying, Andrea; but that does not mean they are off-limits. Raymonde Savoie. I know Quercetin very well from having studied it as part of my herbs and herbal remedies that I make from wild herbs.
One free and significant source of Quercetin is found in the leaves of the quite deceivingly ordinary plant, Evening Primrose, Oenothera biennis.
The whole plant was once used by indigenous peoples in North America, and as many know, the seeds of this plant are the base for Evening Primrose Oil, with potent GLA that helps an array of conditions, among them PMS and ADD. If you collect the leaves for consumption, you must make sure that the plant does not grow within short distance of any parking lot, public or private roads, etc.
because you risk ingesting the pollution from vehicle exhaust fumes. Luckily, this plant grows in many habitats, so you are bound to find it somewhere where it is safe to collect it. Evening Primrose is a biennial plant, so the first year you will find only the flat rosette of leaves growing in a circle close to the ground.
The second-year plants have the distinctive stalks and the typical yellow flowers that only open on cloudy days or after sunset, giving it its common name. This plant is literally my champion of all herbs! Thank you so much for your contribution, Raymonde!
Thanks again for this great research information. Have a great day everyone! Save Our Bones Bulletin: New Imaging Technology Reveals Activity Of Osteoclasts; Protein Found To Facilitate Bone Resorption; Debunking The 10, Steps Myth.
Save Our Bones Bulletin: Gut Microbiome Linked To Bone Loss; Strawberries Found To Improve Cognitive Function; Mollusk-Derived Supplement Improved Bone Density In Mice. This information is not intended to replace recommendations or advice from physicians or other healthcare providers.
Rather, it is intended to help you make informed decisions about your health and to cooperate with your healthcare provider in a joint quest for optimal wellness. If you suspect you have a medical problem, we urge you to seek medical attention from a competent healthcare provider.
Save Institute St Andrews Blvd Boca Raton, FL © Save Institute for Natural Health, Vivian Goldschmidt, MA. All rights reserved. Privacy, Terms, Disclaimers Back to Top. Enter your name and email below to get it all! Home About Our Story Advisory Panel Contact. Osteoporosis Reversal Program Densercise Bone Appétit Osteoporosis Fresh Start Cleanse All Access Bundle.
By Vivian Goldschmidt, MA The Antioxidant That Builds Your Bones And So Much More. Quercetin: A Nutritional Powerhouse That Helps Increase Bone Density The antioxidant quercetin has an indirect but very powerful effect on your bones.
These stabilizing substances, of course, are antioxidants. How The Antioxidant Quercetin Helps Quercetin is one of many antioxidants, but it deserves special mention because its positive effects on the body go beyond the disruption of the oxidative cycle mentioned above.
The Role Of Stress In Your Bone Health Chronic stress is debilitating for many body systems, including your bones.
Dario Citrus fruit for hydration, Mauro Healtb, Marco Pierandrei, M. Although Citrus fruit for hydration epidemiological studies uealth a positive Caloric needs for a balanced lifestylecaloric restriction benefits between dietary vitamin C Antioxidant supplementation and bone mineral density, andd on Antioxidabt levels of vitamin C or other antioxidants Antioxidanh osteoporotic subjects heath scanty. The aim of this study was to evaluate whether antioxidant defenses are decreased in elderly osteoporotic women and, if this is the case, to understand whether osteoporosis is a condition characterized by increased oxidative stress. To answer these questions, plasma vitamins C, E, and A; uric acid; and the enzymatic activities of superoxide dismutase in plasma and erythrocytes and of glutathione peroxidase in plasma were measured in 75 subjects with osteoporosis and 75 controls. Dietary and endogenous antioxidants were consistently lower in osteoporotic than in control subjects.
Open access. Submitted: 20 June Published: 15 May Antioxdant com customercare cbspd. Although most Fuel your energy levels on the prevalence Anfioxidant osteoporosis quoted Fuel your energy levels the literature are from those published in to [ 23 ] the projection is nevertheless very consistent. Thus, osteoporosis is estimated to affect over million people worldwide and 75 million people in Europe, the United States, and Japan [ 4 ].
Ich entschuldige mich, aber meiner Meinung nach lassen Sie den Fehler zu. Es ich kann beweisen. Schreiben Sie mir in PM, wir werden umgehen.
die Interessante Variante