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BMR and long-term health benefits -

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Medical News Today. Health Conditions Health Products Discover Tools Connect. What to know about basal metabolic rate. Medically reviewed by Stacy Sampson, D. Definition Vs. resting metabolic rate How to calculate it Importance Calories required How to change it Summary A person burns calories continually throughout the day in order to sustain basic life functions, such as breathing.

What is it? Share on Pinterest A person may be able to change their BMR through regular cardiovascular exercise. BMR vs. resting metabolic rate RMR. How to calculate BMR. Why is BMR important?

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What Is Metabolic Age? Medically reviewed by Shilpa Amin, M. Metabolic age and health Vs. chronological age BMR Calculation Improving metabolic age Bottom line You may hear about metabolic age and what it means for your health. What does your metabolic age tell you about your health? How is your metabolic age different from your chronological age?

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Read this next. What Is Basal Metabolic Rate? You can use… READ MORE. The 13 Healthiest Root Vegetables. By Rachael Ajmera, MS, RD. How Long Does It Take to Lose Weight? By Gavin Van De Walle, MS, RD. Why Functional Fitness Is Important for Everyone. Medically reviewed by Jake Tipane, CPT.

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A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization. Article ADS MathSciNet PubMed PubMed Central Google Scholar. Yavorska, O. MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data. Greco, M. Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome.

Article MathSciNet Google Scholar. Verbanck, M. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Zhao, Q. Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score.

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Genet Epidemiol. Mendelian randomization with invalid instruments: Effect estimation and bias detection through Egger regression. Timmers, P. Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances.

Elife 8 , 1 Paternoster, R. Using the correct statistical test for the equality of regression coefficients. Criminology 36 , — Online sample size and power calculator for Mendelian randomization with a binary outcome.

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The authors thank the Neale Lab, Pilling et al. for providing the summary-level data. School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

Department of Environmental, Occupational, and Geospatial Health Sciences, Graduate School of Public Health and Health Policy, The City University of New York, 55 West th St, New York, NY, , USA. You can also search for this author in PubMed Google Scholar. Correspondence to C.

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Skip to main content Thank you for visiting nature. nature scientific reports articles article. Download PDF. Subjects Endocrine system and metabolic diseases Epidemiology Evolutionary theory Genetics research Medical research. Abstract Observationally, the association of basal metabolic rate BMR with mortality is mixed, although some ageing theories suggest that higher BMR should reduce lifespan.

Introduction Metabolism has long been linked to the process of aging and longevity but the evidence from studies of their associations is not always in accordance 1.

Table 1 Mendelian randomization of basal metabolic rate Neale Lab on father's and mother's attained age Pilling et al. CI: confidence interval; GV: genetic variant; IVW: inverse-variance weighting; LL: lower limit; MR: Mendelian randomization; MR-RAPS: Mendelian Randomization Robust Adjusted Profile Score; MR-PRESSO: Mendelian Randomization Pleiotropy Residual Sum and Outlier; SE: standard error; UL: upper limit; WM: weighted median.

Full size table. Table 2 Mendelian randomization of basal metabolic rate Neale Lab on survival to old age Deelen et al. Discussion Using MR and outcomes that obviate survival bias, we have shown that genetically higher BMR was associated with reduced parental attained age.

Methods We conducted an MR study of the association of BMR with parental attained age as the primary outcome using a two-sample MR approach by applying genetic predictors of the exposure to GWASs of outcomes with summary statistics. Data source Basal metabolic rate Genetic predictors of BMR were retrieved from UK Biobank summary statistics provided by Neale Lab Survival to the 90th and 99th percentile of ages Genetic associations with odds of survival to the 90th and 99th percentile of ages or above compared to the 60th percentile of age or below, where percentiles of age were country-, sex-, and birth cohort-specific, were retrieved from a meta-analysis of GWASs of survival to old age Assessment of confounding We examined whether the GVs for BMR were associated with five key potential confounders of the GVs on outcome related to socioeconomic status and lifestyle attributes, including a measure of deprivation Townsend index phenotype code, , age at completion of full-time education phenotype code, , number of days per week walked for 10 min or more phenotype code, , current smoking phenotype code, , and alcohol intake frequency phenotype code, using summary statistics from the UK Biobank provided by the Neale Lab 55 , at Bonferroni-corrected significance, i.

Statistical analysis We harmonized the effect allele of a GV for exposure and outcome based on the allele letters in general. Eithics approval and consent to participate We only used publicly available summary-level data in the current study. Abbreviations BMR: Basal metabolic rate CI: Confidence interval GV: Genetic variant GWAS: Genome-wide association study IVW: Inverse-variance weighting MR: Mendelian randomization MR-RAPS: Mendelian randomization robust adjusted profile score MR-PRESSO: Mendelian randomization pleiotropy residual sum and outlier.

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Author information Authors and Affiliations School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China Jack C. Mary Schooling Department of Environmental, Occupational, and Geospatial Health Sciences, Graduate School of Public Health and Health Policy, The City University of New York, 55 West th St, New York, NY, , USA C.

Mary Schooling Authors Jack C. Ng View author publications. View author publications. Ethics declarations Competing interests The authors declare no competing interests.

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Supplementary Information. Supplementary Tables. Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4. About this article. Cite this article Ng, J.

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You Rehydration for children Bulk up muscle mass about metabolic age benefuts what it Healtn for your health. But what is metabolic age, how is it Olng-term, and Lean protein diet plan does it really mean? Your metabolic age is how lpng-term basal metabolic rate BMRor how ad calories your body burns at rest, compares to the average BMR for people of your chronological age in the general population. Continue reading as we explore the theory behind metabolic age, what it means for your health, and how you can change it. Natasha Trentacosta is a sports medicine specialist and orthopedic surgeon at Cedars-Sinai Kerlan-Jobe Institute in Los Angeles. As with body mass index BMIBMR has its critics. According to Trentacosta, neither measure factors in body composition properly.