Bone health catechins, R. Catecins There Cxtechins in That Cup of Tea? However, previous studies hralth bone mineral density and Calorie counting logbook Bone health catechins are all cross-sectional, and the results are inconsistent. Arthritis Rheum ; 46 : 83 — Funding This study was supported by Grant TTMMH from Taitung MacKay Memorial Hospital, Taitung, Taiwan and KSVGH from Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Bone health catechins -

Liao S, Kao YH, Hiipakka RA Green tea: biochemical and biological basis for health benefits. Vitam Horm — PubMed Google Scholar. Yang CS, Yang GY, Chung JY et al Tea and tea polyphenols in cancer prevention.

Adv Exp Med Biol — Liao S, Umekita Y, Guo J et al Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate. Cancer Lett — Article PubMed Google Scholar.

Yang CS, Lee MJ, Chen L Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies. Cancer Epidemiol Biomarkers Prev — Kao YH, Hiipakka RA, Liao S Modulation of obesity by a green tea catechin.

Am J Clin Nutr — Katiyar SK, Elmets CA Green tea polyphenolic antioxidants and skin photoprotection Review. Int J Oncol — Kondo K, Kurihara M, Fukuhara K Mechanism of antioxidant effect of catechins. Methods Enzymol — Kanis J, Johnell O, Gullberg B et al Risk factors for hip fracture in men from southern Europe: the MEDOS study.

Mediterranean Osteoporosis Study. Osteoporos Int — Johnell O, Gullberg B, Kanis JA et al Risk factors for hip fracture in European women: the MEDOS Study. J Bone Miner Res — Hegarty VM, May HM, Khaw KT Tea drinking and bone mineral density in older women. Chen CH, Ho ML, Chang JK et al Green tea catechins enhance the expression of osteoprotegerin OPG in pluripotent stem cells.

J Orthop Surg Taiwan — Google Scholar. Dahir GA, Cui Q, Anderson P et al Pluripotential mesenchymal cells repopulate bone marrow and retain osteogenic properties. Clin Orthop S— Hoover PA, Webber CE, Beaumont LF et al Postmenopausal bone mineral density: relationship to calcium intake, calcium absorption, residual estrogen, body composition, and physical activity.

Can J Physiol Pharmacol — Am J Epidemiol — Wu CH, Yang YC, Yao WJ et al Epidemiological evidence of increased bone mineral density in habitual tea drinkers. Arch Intern Med — Karsenty G, Ducy P, Starbuck M et al Cbfa1 as a regulator of osteoblast differentiation and function.

Bone — Ducy P, Karsenty G Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol — Nakashima K, Zhou X, Kunkel G et al The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.

Cell — Unno T, Kondo K, Itakura H et al Analysis of - -epigallocatechin gallate in human serum obtained after ingesting green tea. Biosci Biotechnol Biochem — van het Hof KH, Wiseman SA, Yang CS et al Plasma and lipoprotein levels of tea catechins following repeated tea consumption.

Proc Soc Exp Biol Med — Download references. We appreciate the help of Prof. Shutsung Liao, Department of Biochemistry and Molecular Biology, University of Chicago, USA, who provided the green tea catechins.

We thank Shun-Cheng Wu and Yi-Jen Chen for helping the experiment process. This study was support by National Science Council Taiwan grant NSC93—B— Department of Orthopedics, Faculty of Medical School, College of Medicine, Kaohsiung Medical University, No.

Department of Physiology, Faculty of Medical School, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Orthopedic Research Center, Kaohsiung Medical University, Chung-Ho Memorial Hospital, Kaohsiung, Taiwan. Department of Orthopedics, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan. Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. Department of Orthopedic Surgery, Fooyin University Hospital, Ping-Tung County, Taiwan. You can also search for this author in PubMed Google Scholar.

Updated association of tea consumption and bone mineral density: A meta-analysis. Medicine Baltimore 96 , e Sun, K.

Association between tea consumption and osteoporosis: A meta-analysis. Shen, C. Tea flavonoids for bone health: from animals to humans.

Weaver, C. Flavonoid intake and bone health. Article PubMed PubMed Central Google Scholar. Kim, Y. Changes in antioxidant phytochemicals and volatile composition of Camellia sinensis by oxidation during tea fermentation. Food Chem. Nash, L. Tea and bone health: Findings from human studies, potential mechanisms, and identification of knowledge gaps.

Food Sci. Factors affecting the levels of tea polyphenols and caffeine in tea leaves. Massey, L. The effect of dietary caffeine on urinary excretion of calcium, magnesium, sodium and potassium in healthy young females.

Heaney, R. Effects of caffeine on bone and the calcium economy. Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial.

Dostal, A. Long-term supplementation of green tea extract does not modify adiposity or bone mineral density in a randomized trial of overweight and obese postmenopausal women. Wang, Y. Associated factors for osteoporosis and fracture in Chinese elderly. Duan, P. Oolong tea drinking boosts calcaneus bone mineral density in postmenopausal women: a population-based study in southern China.

Osteoporos 15 , Li, X. Tea consumption and bone health in Chinese adults: a population-based study. Huang, C. Conforti, A. Yerba Mate Ilex paraguariensis consumption is associated with higher bone mineral density in postmenopausal women.

Bone 50 1 , 9—13 Hwang, J. Clinical practice guidelines for the prevention and treatment of osteoporosis in Taiwan: summary. Liu, C. Incorporating development stratification of taiwan townships into sampling design of large scale health interview survey.

Health Manag. CAS Google Scholar. Tang, G. Phytochemical Composition and Antioxidant Capacity of 30 Chinese Teas. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. Kashiwa, K. Effects of epigallocatechin gallate on osteogenic capability of human mesenchymal stem cells after suspension in phosphate-buffered saline.

Tissue Eng. Part A 16 , 91— Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro. Protective effect of green tea polyphenols on bone loss in middle-aged female rats.

Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation. Effect of long-term green tea polyphenol supplementation on bone architecture, turnover, and mechanical properties in middle-aged ovariectomized rats.

Tissue Int. Siris, E. Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment.

JAMA , — Jeremiah, M. Diagnosis and Management of Osteoporosis. Physician 92 , — Recker, R. Bone gain in young adult women. JAMA , — Ohta, H. Bone resorption versus estrogen loss following oophorectomy and menopause. Maturitas 43 , 27— Lindsay, R.

Estrogens, bone mass, and osteoporotic fracture. Prince, R. Prevention of postmenopausal osteoporosis. A comparative study of exercise, calcium supplementation, and hormone-replacement therapy.

New Engl. Everett, E. Green tea and bone metabolism. Alswat, K. Gender disparities in osteoporosis. Lloyd, J. Body mass index is positively associated with bone mineral density in US older adults.

De Laet, C. Body mass index as a predictor of fracture risk: a meta-analysis. Zhao, L. Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. Kanis, J. A family history of fracture and fracture risk: a meta-analysis. Bone 35 , — Yu, C.

A cross-sectional study for estimation of associations between education level and osteoporosis in a Chinese men sample. BMC Musculoskelet. Kuo, C. Rheumatoid arthritis prevalence, incidence, and mortality rates: a nationwide population study in Taiwan.

Download references. This study was supported by Grant TTMMH from Taitung MacKay Memorial Hospital, Taitung, Taiwan and KSVGH from Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. The funding source was not involved in the study or article preparation. Center for Health Management, Kaohsiung Veterans General Hospital, No.

Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, No. Taipei Veterans General Hospital, Taitung Branch, No. School of Nursing, College of Medicine, National Taiwan University, No.

Department of Nursing, National Taiwan University Hospital, No. Department of Medical Research, Taitung MacKay Memorial Hospital, 1, Lane , Changsha Street, Taitung City, , Taiwan. Master Program in Biomedicine, College of Science and Engineering, National Taitung University, No.

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Download PDF. Subjects Endocrinology Risk factors. Abstract Few studies compared the effects of non-fermented and fermented tea among the general population. Introduction Osteoporosis OP , which is a chronic deconditioning musculoskeletal disease, occurs predominantly in postmenopausal women and men older than 50 years.

Methods Data sources By combining genetic and medical information, Taiwan Biobank TWB performed large-scale cohort and case—control studies on local diseases. Study population A total of respondents who were habitual tea drinkers were identified from to with a mean follow-up period of 3.

Figure 1. Full size image. Full size table. Table 2 Multivariate Cox proportional hazards regression model for osteoporosis. Table 3 Multivariate Cox proportional hazards regression model for osteoporosis by sex and age. Figure 2. Discussion Our nationwide population-based study suggested that female sex and age of 60 years or older were the significant predictors of OP in Taiwan.

Strengths and limitations Being a nationwide population-based dataset with a relatively large representative sample size, the major strength of the use of TWB was the enhancement of external validity of the current findings. Conclusions and implications The present study demonstrated that OP risk increased in men with a family history of OP and in women with advanced age, postmenopausal status, total daily tea consumption of over six cups, and lower BMI.

Data availability Not applicable. Abbreviations OP: Osteoporosis TWB: Taiwan biobank DM: Diabetes mellitus BMD: Bone mineral density BMI: Body mass index QUS: Quantitative ultrasound mL: Millimeters SD: Standard deviation HR: Hazard ratio aHR: Adjusted hazard ratio.

References Hernlund, E. Article CAS Google Scholar Wright, N. Article PubMed Google Scholar Lee, J. Article Google Scholar Lin, Y.

PubMed Google Scholar Burge, R. Article PubMed Google Scholar Briot, K. Article CAS PubMed Google Scholar Ko, C.

Article CAS PubMed Google Scholar Cosman, F. Article CAS PubMed PubMed Central Google Scholar Lau, E. Article CAS PubMed Google Scholar Zhang, Z.

Article Google Scholar Sun, K. Article PubMed Google Scholar Weaver, C. Article PubMed PubMed Central Google Scholar Kim, Y. Article CAS Google Scholar Nash, L. Article PubMed Google Scholar Lin, Y. Article CAS PubMed Google Scholar Massey, L. Article CAS Google Scholar Heaney, R.

Article CAS PubMed Google Scholar Shen, C. Article CAS PubMed Google Scholar Dostal, A. Article CAS PubMed Google Scholar Wang, Y. Article Google Scholar Duan, P. Article PubMed Google Scholar Li, X. Article CAS PubMed Google Scholar Huang, C.

Article PubMed PubMed Central Google Scholar Conforti, A. Article Google Scholar Hwang, J. Article PubMed Google Scholar Liu, C. CAS Google Scholar Tang, G. Article CAS PubMed Google Scholar Kashiwa, K. Article CAS PubMed Google Scholar Siris, E.

Article CAS PubMed Google Scholar Jeremiah, M. PubMed Google Scholar Recker, R. Article CAS Google Scholar Ohta, H. Article CAS PubMed Google Scholar Lindsay, R. Article CAS PubMed Google Scholar Prince, R. Article CAS PubMed Google Scholar Everett, E.

Article CAS PubMed PubMed Central Google Scholar Shen, C. Article CAS PubMed PubMed Central Google Scholar Alswat, K. Article PubMed PubMed Central Google Scholar Lloyd, J. Article PubMed Google Scholar De Laet, C. Article PubMed Google Scholar Zhao, L. Article CAS PubMed Google Scholar Kanis, J.

Article CAS PubMed Google Scholar Yu, C. Article CAS PubMed PubMed Central Google Scholar Kuo, C. Article PubMed Google Scholar Download references. Acknowledgements The authors wish to thank the Taiwan Biobank for the provision of anonymous data. Funding This study was supported by Grant TTMMH from Taitung MacKay Memorial Hospital, Taitung, Taiwan and KSVGH from Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Author information Authors and Affiliations Center for Health Management, Kaohsiung Veterans General Hospital, No. View author publications. Ethics declarations Competing interests The authors declare no competing interests. Additional information Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4. About this article. Cite this article Hsu, CL.

Hsalth are provided in two different formats for consumer and professional users. These resources are produced by Dr. Rachel Scherr and her research staff. Produced by Michelle Chellino, Hanee Hyun Hee Park, Janice Ho, BS, Rachel E. Scherr, PhD, Carl L. Bond tea has been catecuins Bone health catechins possess antioxidant, catrchins, and antibacterial qualities that regulate Bone health catechins endocrine system. Previous epidemiological studies found that the bone mineral density Healh of postmenopausal cqtechins with a Bpne of tea drinking was Bone health catechins than heealth of women without Raspberry sauce recipes tea consumption. However, the effects of green tea catechins on osteogenic function have rarely been investigated. In this study, we tested - -epigallocatechingallate EGCGone of the green tea catechins, on cell proliferation, the mRNA expressions of relevant osteogenic markers, alkaline phosphatase ALP activity and mineralization. ALP activity was also significantly augmented upon EGCG treatment for 4 days, 7 days and 14 days. Furthermore, mineralizations assayed by Alizarin Red S and von Kossa stain were enhanced after EGCG treatment for 2—4 weeks in D1 cell cultures.