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THIS Herb is the #1 Absolute BEST for liver diseases (Fatty Liver, Hepatitis and Cirrhosis)Citrus aurantium for liver health -
Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice. Our results indicate that CAE treatment decreased HFD-induced expression levels of inflammatory cytokines IL-1α, TNF-α, and IL-6 in a dose-dependent manner.
This was in line with well-characterized anti-inflammatory effects of PMFs. Flavonoid composition of orange peel and its association with antioxidant and anti-inflammatory activities.
Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel Citri reticulatae pericarpium.
Nrf2 is a nuclear transcription factor, which is known to initiate a cytoprotective signal cascade against various oxidative stresses.
Role of nrf2 in oxidative stress and toxicity. Nobiletin promotes antioxidant and anti-inflammatory responses and elicits protection against ischemic stroke in vivo.
Brain Res. Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism. Liver Physiol. Treatment of nonalcoholic fatty liver disease: role of AMPK.
AMPK facilitates nuclear accumulation of Nrf2 by phosphorylating at serine Free Radic. In this study, CAE prevented HFD-induced fatty liver changes by lowering plasma TG and CHO levels. Moreover, the anti-inflammatory and Nrf2-enhancing effects of CAE were confirmed in the HFD animal model.
Additional mechanistic and safety-related studies on CAE are needed to assess its applicability in the treatment of NAFLD. This work was supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries IPET through the High Value-added Food Technology Development Program or Project , funded by the Ministry of Agriculture, Food and Rural Affairs MAFRA, SB Already have an account?
Sign in here. Biological and Pharmaceutical Bulletin. Online ISSN : Print ISSN : ISSN-L : Journal home Advance online publication All issues Featured articles About the journal. Preventive Effect of Citrus aurantium Peel Extract on High-Fat Diet-Induced Non-alcoholic Fatty Liver in Mice.
Hyoung-Yun Han Korea Institute of Toxicology College of Veterinary Medicine and Institute of Veterinary Science, Chungnam National University Sung-Kwon Lee Nutrapharm Tec Bong-Keun Choi Nutrapharm Tec Dong-Ryung Lee Nutrapharm Tec Hae Jin Lee Nutrapharm Tec Tae-Won Kim Corresponding author College of Veterinary Medicine and Institute of Veterinary Science, Chungnam National University.
Corresponding author. Keywords: cholesterol , polymethoxyflavone , triglyceride. JOURNAL FREE ACCESS FULL-TEXT HTML. Published: February 01, Received: September 12, Released on J-STAGE: February 01, Accepted: November 19, Advance online publication: - Revised: -.
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Weight g. Body weight. Liver weight. International Journal of Medical Sciences. Global reach, higher impact. Int J Biol Sci ; 16 5 Beijing University of Chinese Medicine, Beijing, , China 2. Patent Examination Cooperation Tianjin Center of the Patent Office, Tianjin, , China 3.
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, , China. Xueqin Yang, Beijing Key Laboratory of Health-cultivation, Beijing University of Chinese Medicine, Beijing, , China. E-mail address: yangxqcom.
Cheng Lu, Insti tute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing , China. Yuanyan Liu, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing , China. At the end of experiment, rats were sacrificed and blood samples were collected, then serum was separated, glucose, leptinlevel, lipid profile as well as AST, ALT and ALP enzymes were determined.
In conclusion,the results showed that administration of citrus unripe or ripe sour orange peel at levels 3 or 1. Over weight and obesity are the fifth leading risk for global death. At least 2. Obesity is a significant and increasing public health problem worldwide.
Even through there are several treatments, such as surgery and drugs, there seems to be no efficient treatment without potential side effects. In addition to a lifestyle modification, natural alternatives may provide increased health expectancy.
Several plants possess anti-obesity potential and have been poorlystudied, while others are not even promoted Claudia et al. Polymethoxy flavones the major components of orange peel have been found to have health benefits including anti-inflammatory, anti-carcinogenic, anti-viral anti-oxidant, anti-thrombogenic and anti-atherogenic properties Li et al.
Therefore, the present study was carried out to investigate the effects of supplemented HFD with DURSOP or DRSOP on serum leptin, glucose, lipid profile and liver enzymes of albino rats. Sour orange Citrus aurantium were obtained from El Abour market.
The raw orange ripe and unripe were washed carefully and peel cut into small pieces to be exposed to solar energy at national research center and ground to fine powder.
Casein, vitamins,minerals, cellulose, choline chloride were obtained from Elgomhoria Company, Cairo, Egypt. Kits for biochemical analysis were obtained from Gamma trade Co-for Pharmaceutical and chemicals.
Dokki, Egypt. Thirty-six male albino rats of Sprague Dawleystrain 25 days age 40±5 g b. wt were obtained from the laboratory of animal's colony, ministry of health and population, Helwan, Cairo, Egypt.
Rats were housed in individual cages under hygienic laboratory conditions and were fed on basal diet adlibitum for one week for adaptation in the animal house of faculty of Home Economics, HelwanUniversity.
Reeves et al. The salt mixture and vitamin mixture were prepared according to Hegested et al. After a period of adaptation on basal diet, rats were divided into two main groups.
The first main group 6 rats fed on basal diet negative group. Supplementation of diet with dried unripe or ripe dried peel of sour orange was at the expense of starch.
Rats of the second main group were divided into five subgroups. one of them 6 rats was fed on HFD used as a positive control group and the other four subgroups were fed on HFD containing 1.
At the end of the experiment period, the rats were starved for 12h and then sacrificed under ether anaesthetized. Blood samples were collected from hepatic portal vein by the means of fine capillary glass tubes Schermer, Blood samples were received into clean dry centrifuge tube and left to clot at room temperature, then centrifuged for 10 minutes at r.
to separate serum. Serum was careful separated into dry clean Wasserman tubes, using a Pasteur pipette and kept frozen at o C till estimation of some biochemical parameters.
Serum samples used for determination of total cholesterol Allain et al. While serum low- density lipoprotein cholesterol LDL-C and very low-densitylipoproteincholesterol VLDL-C were calculated according to theequation of Friedwald et al.
Serum Aspartate Amino Transferase AST and Alaine Amino Transferase ALT Reitman and Frankel, andAlkalinephosphatase ALP Belfield and Goldberg , Statistical analysis:was carried out using SPSS statistical software version 11 SAS. Effect of sour orange peel citrus aurantium on lipid profile of Albino Rats fed on high fat diet.
In this respect Wu et al. Our results revealed that all animals groups which fed on HFD supplemented with 1. Concerning the TG results revealed that groups fed on HFD supplemented with 1. The phenolic and flavonoids compounds extracted from DURSOP and DRSOP it could be identify 18 fraction, characterizes with high amounts of Naringin, Hespirdin ,Apig 6 rhamnose 8- glucose , Rutin and Quercetrin to be the predominant compounds.
Concerning phenolic compounds resulted in 19 fraction, while DRSOP showed 21 fraction. The predominant phenolic in DRSOP was pyrogallol, whichamounted The predominant phenolic in DURSOP , isoFerulic, Benzoic,Ferulic, catechein, P-OH-benzoic, caffeine and 3.
Therefore, our results revealed that Egyptian sour orange peel have considerable number of healthy compounds namely polyphenols and flavonoids. Biological results also showed that the supplementation of HFD with DURSOP or DRSOP at levels 3 or 1.
In this respect , lee et al. In this concern kelleya et al. Citrus peel treatment reduced body weight gain and decreasedepididymal fat, mesenteric fat, plasma and hepatic TG levels Karagozlu et al. Concerning serum lipoprotein cholesterol resultpresented in table 2 showed the effect of HFD supplemented with 1.
Our results revealed that all animal groups fed on HFD supplemented with 1. On the other hand result showed that all groups fed on HFD supplemented with 1. It is known that there is a correlation between lipoprotein cholesterol changes and obesity.
In obesity HDL-clevel and elevation of HDL-C is one of the targets for ant-obesity treatment Vozarova et al. Effect of sour orange peel Citrus aurantium on serum glucose, leptin and liver functions in albino rats fed on high fat diet.
Table 3 illustrate the effect of two levels 1. Animal groups fed on HFD supplemented with 1. In this respect Alam et al. Naringin supplementation also improved the mitochondrial respiration in these rats, suggesting an improvement in mitochondrial compartment dysfunction and lipid energy expenditure by liver.
In conclusion the results taken together indicated that the dried Egyptian sour orange peel citrus aurantium as a good sources of phenols and flavonoids incorporate into HFD could contribute to potential management of obesity, being beneficial to alleviate the complications present in obesity.
Table 1 : Effect of high fat diet supplemented with dried unripe or ripe sour orange peel on serum total cholesterol and triglycerides of 25 days albino rats:.
International Journal of Medical Sciences. Healfh Strength training workouts, higher impact. Int J Biol Sci ; auranium 5 Kiver University of Chinese Medicine, Beijing,China 2. Patent Examination Cooperation Tianjin Center of the Patent Office, Tianjin,China 3. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing,China. In a study Strength training workouts lover the Aurantikm Pacific Journal of Tropical Strength training workouts, mice were given doses of Citrus aurantium hdalth CAE to see if could help livver the effect Sports nutrition guide bile Enzymes for digestion ligation Citrus aurantium for liver health -induced Recovery for seniors fibrosis, with promising results. The researchers, from Citrhs, noted that Citrus aurantium, hhealth is native to South East Asia and commonly used as Citeus pickle in Indian cooking, has abundant polymethoxy flavones, including nobiletin. However, they added it was unknown if CAE could help prevent cholestasic liver fibrosis, caused when bile cannot flow from the liver to the duodenum. The study worked on five groups of mice, with the first three composed of a control group of sham-operated mice; mice with liver injury caused by BDL; and BDL mice treated with Silymarin mg for four weeks. The last two groups were composed of BDL mice given CAE in different doses. The first group was treated with 50mg of CAE for four weeks, the second with mg of CAE, also for four weeks. The findings revealed that BDL mice has higher levels of liver injury compared to the control group, as expected.
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