American Cagdiovascular Association News Stories American Healhh Quercetin and wound healing News covers heart disease, stroke and related health issues. Heath, hesperidin prevented the slow inactivation phase of I Na Virus-killing technology In Ac management tips, in the three prospective cohorts in which flavonol and flavone intakes and total cardiovascular mortality were examined Iowa, 77 Kuopio, 78 WHS 80there was no observed relationship between these intakes and death from cardiovascular disease. No prospective cohort studies were available on nonfatal coronary heart disease and the other five classes of flavonoids. The administration of hesperidin in animals restored nitrite in the cardiac tissues, and decreased arrhythmias, apoptosis, and inflammation.

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What's the link between cocoa flavanols and heart disease?

Flavonoids and cardiovascular health -

Catechin-rich oil has been reported to have an anti-hypertensive effect, as it upregulates nitric oxide NO levels. Research has shown a notable decrease in the wall-to-lumen ratio to near normal values under NO deficiency Benifuuki tea is a popular green tea consumed in Japan. It is a rich source of - -epigallocatechinO- 3-O-methyl gallate.

This polyphenol has a significant effect on the inhibition of the angiotensin I-converting enzyme. Benifuuki tea has also been shown to have an anti-hypertensive effect, especially on systolic pressure Oranges are one of the richest sources of hesperidin. Hesperidin is one of the major anti-oxidant flavonoids In a preclinical study, the anti-hypertensive effects of glucosyl hesperidin and hesperetin were evaluated in animal models spontaneously hypertensive rats and normotensive Wistar-Kyoto rats.

Similarly, the intraperitoneal administration of hesperitin to spontaneous hypertensive rats resulted in a notable decrement in systolic blood pressure. Such a response was associated with the inhibition of NO synthase.

The effect was observed due to NO-mediated vasodilation The possible anti-hypertensive effects of hesperidin have been studied in type-2 diabetes patients. In a clinical study, patients were administered a mg hesperidin capsule every day for 6 days.

The placebo group received a starch filler capsule. Systolic and diastolic blood pressure were taken into consideration when determining the blood pressure of the patients. The levels of tumor necrosis factor- TNF -α and interleukin IL -6 were notably decreased in the hesperidin treated group.

An increase in total anti-oxidant capacity was also observed. This effect may be due to one of the metabolites of hesperidin; that is, hesperetin-O-glucuronide. The metabolite is associated with endothelium-dependent vasodilation and the suppression of inflammation of endothelial cells The pharmacological effects of the administration of hesperidin and glucosyl hesperidin along with naringin were evaluated in stroke-prone spontaneously hypertensive rats.

The study showed that the administration of these flavonoids resulted in the restoration of blood pressure and a decrement in thrombolytic tendency.

The biosynthesis of NO was also increased. Further, the endothelial function was restored due to the administration of these natural flavonoids Genistein is another documented isoflavone present in various soybeans and soy products.

Genistein has been the subject of considerable interest by the biomedical community due to its apparent positive effects on major human illnesses, such as cancer. Mechanistically, genistein has a propensity for apoptotic activation, arresting the cell cycle, and also has anti-angiogenic, anti-cancer, and anti-apoptotic effects.

Genistein has a tendency to regulate NO biosynthesis. Specifically, it increases the expression of NO. It also increases aortic wall thickness and decreases hypertension In high-sodium chloride NaCl diet-fed rats, the administration of genistein blunted hypertension.

Studies also suggest that it has anti-hypertensive effects associated with the autonomic nervous system. The key mechanism by which genistein mediates cardiovascular function is via its association with estrogen receptors.

Genistein is capable of binding to the estrogen-receptor beta Erβ and activating ER-dependent gene transcription. Genistein also greatly affects the protein expression implicated in vascular tone control; that is, the atrial natriuretic peptide receptor, endothelin converting enzyme 1, angiotensin converting enzyme, atrial natriuretic peptide receptor, and endothelial NO synthase 34 , Erythropoietin and its receptor play a defensive role in the prevention of pulmonary hypertension.

In one study, the administration of genistein in hypobaric conditions prevented vascular remodeling and pulmonary hemodynamics. Vasodilation associated with phosphatidylinositol 3-kinase and NO was also observed Due to the rise in hypoxia-inducible factor HIF -1α, hypertension-induced myocardial injury is often followed by impaired myocardial glucolipid metabolism.

The potential benefits of apigenin for hypertension have been studied. Research has shown that the administration of apigenin resulted in a decrement in blood pressure and restored heart weight and serum angiotensin II.

Additionally, apigenin administration resulted in a decrement in the expression of carnitine palmitoyltransferase-1, peroxisome proliferator-activated receptor-α, glycerolphosphate acyltransferase genes, and glucose transporter-4 proteins.

It has been suggested that apigenin may have beneficial effects in hypertensive cardiac hypertrophy Table 1 details the effects of other flavonoids on hypertension. Arrhythmia refers to a diverse variety of disorders associated with abnormalities in heart rate and rhythm.

Based on heart rate, arrhythmias are classified as bradyarrhythmias or tachyarrhythmias. They are also classified based on their origin, mode of propagation, and the syndromes with which they are associated.

Patients with arrhythmias can present with a wide range of clinical symptoms, ranging from being completely asymptomatic to sudden cardiac arrest. As arrhythmias can be paroxysmal, assessing their exact prevalence is challenging. The event of cardiac arrhythmia addresses the diagnosis and management of multiple arrhythmias, and also the involvement of multidisciplinary teams in the care of such cases.

Quercetin has been observed to have anti-ischemic and anti-arrhythmic effects, and has a beneficial role in the homeostasis of patients with ischemic heart disease A total decrement in the depression of ST segment depression was also observed due to quercetin administration The Ganshanbian herb is used in the treatment of cardiac arrhythmias.

In one study, the flavonoid-rich fraction of Ganshanbian was isolated and evaluated to examine its anti-arrhythmic effects in an animal model. The administration of the flavonoid-rich fraction to the animals resulted in an increase in the appearance time and a decrease in the duration of ischemia and heartbeat.

There was an increase in the expression of cell membrane associated messenger ribonucleic acid mRNA of L-calcium channels α type Ca L-α1C.

The potential anti-arrhythmic effects of flavonoids from the Chinese medicine Viscum coloratum have also been evaluated.

The administration of 0. In another study, the administration of the flavonoid-rich fraction of Viscum coloratum shortened the action potential and led to a decrement in the arrhythmia index.

According to epidemiological studies, the intake and consumption of green tea and cardiovascular health are positively associated. Circ J. Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women.

Inhibition by soya isoflavones of human polymorphonuclear leukocyte function: possible relevance for the beneficial effects of soya intake. Shenouda SM Vita JA. Effects of flavonoid-containing beverages and EGCG on endothelial function. J Am Coll Nutr. Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials.

The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: relationship with the metabolic status. Arts IC Hollman PC. Polyphenols and disease risk in epidemiologic studies.

Cano A Garcia-Perez MA Tarin JJ. Isoflavones and cardiovascular disease. Polyphenolic grape extract inhibits platelet activation through PECAM an explanation for the French paradox. Alcohol Clin Exp Res. Effects of cocoa flavanols on risk factors for cardiovascular disease.

Asia Pac J Clin Nutr. Higdon JV Frei B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr. Huntley AL. The health benefits of berry flavonoids for menopausal women: cardiovascular disease, cancer and cognition.

Flavonoid-rich grapeseed extracts: a new approach in high cardiovascular risk patients? Int J Clin Pract. Selected dietary flavonoids are associated with markers of inflammation and endothelial dysfunction in U.

Manach C Mazur A Scalbert A. Polyphenols and prevention of cardiovascular diseases. Curr Opin Lipidol. Middleton E Jr Kandaswami C Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

Pharmacol Rev. Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease. Mol Nutr Food Res. Soy protein, isoflavones, and cardiovascular health: an American Heart Association Science Advisory for professionals from the Nutrition Committee.

The effect of the phytoestrogen genistein on myocardial protection and preconditioning in hypercholesterolemia. Cardiovasc Drugs Ther. Basu A Rhone M Lyons TJ.

Berries: emerging impact on cardiovascular health. Nutr Rev. Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31—June 1, , Washington, DC. Analysis of flavanols in foods: what methods are required to enable meaningful health recommendations?

Rudkowska I. Functional foods for cardiovascular disease in women. Menopause Int. Rudkowska I Jones PJ. Functional foods for the prevention and treatment of cardiovascular diseases: cholesterol and beyond. Expert Rev Cardiovasc Ther.

Antioxidant effects of cocoa and cocoa products ex vivo and in vivo: is there evidence from controlled intervention studies? Curr Opin Clin Nutr Metab Care.

Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs. Mol Aspects Med. Sies H. Polyphenols and health: update and perspectives. Steinberg FM Bearden MM Keen CL. Cocoa and chocolate flavonoids: implications for cardiovascular health.

Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease: the Zutphen Elderly Study. Dietary catechins in relation to coronary heart disease death among postmenopausal women. Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study.

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Hertog MG Feskens EJ Kromhout D.

Antioxidant flavonols and coronary heart disease risk. Antioxidant flavonols and ischemic heart disease in a Welsh population of men: the Caerphilly Study.

Intake of flavonols and flavones and risk of coronary heart disease in male smokers. Intake of flavonoids, carotenoids, vitamins C and E, and risk of stroke in male smokers.

Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med. Quercetin intake and the incidence of cerebrovascular disease.

Flavonoid intake and coronary mortality in Finland: a cohort study. Flavonoid intake and risk of chronic diseases. Dietary intakes of flavonols and flavones and coronary heart disease in US women.

Am J Epidemiol. Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Flavonoid intake and the risk of ischemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischemic Heart Disease Risk Factor Study.

Relation between intake of flavonoids and risk for coronary heart disease in male health professionals. Ann Intern Med. Flavonoid intake and the risk of cardiovascular disease in women. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women.

Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. Intake of specific flavonoid classes and coronary heart disease — a case-control study in Greece. Intake of specific flavonoids and risk of acute myocardial infarction in Italy. Public Health Nutr.

Willett W. Nutritional Epidemiology , 2nd ed. New York: Oxford University Press ; Google Preview. Hertog MG. Flavonols and flavones in foods and their relation with cancer and coronary heart disease risk.

PhD dissertation. Koninklijke Bibliotheek, The Hague, Hertog MGL Hollman PCH Katan MB. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands.

Hertog MGL Hollman PCH van de Putte B. Content of potentially anticarcinogenic flavonoids in tea infusions, wine and fruit juices. Hertog MGL Hollman PCH Venema DP. Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoids in vegetables and fruits.

Arts ICW Hollman PCH. Optimization of a quantitative method for the determination of catechins in fruits and legumes. Arts IC van de Putte B Hollman PC. Catechin contents of foods commonly consumed in The Netherlands. Fruits, vegetables, staple foods, and processed foods.

Arts IC van De Putte B Hollman PC. Tea, wine, fruit juices, and chocolate milk. Intake of dietary phytoestrogens by Dutch women. US Department of Agriculture. Usda Database for the Flavonoid Content of Selected Foods. Beltsville, MD: Agricultural Research Service, Nutrient Data Laboratory; Usda-Iowa State University Database on the Isoflavone Content of Foods.

Usda database for the proanthocyanidin content of selected foods. Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. Starke H Herrmann K. Die phenolischen Inhaltsstoffe des Obstes.

Veränderungen des Flavonolgehaltes während der Fruchtenwicklung. Changes in flavonol concentrations during fruit development]. Z Lebensm Unters Forsch. Wildanger W Herrmann K.

Die Flavonole des Obstes [The phenolics of fruits. The flavonols of fruits]. Mattila P Astola J Kumpulainen J. Determination of flavonoids in plant material by HPLC with diode-array and electro-array detections.

Flavonol and flavone intakes in US health professionals. US Department of Agriculture , Agricultural Research Service. USDA Database for the Isoflavone Content of Selected Foods, Release 2.

Usda Database for the Flavonoid Content of Selected Foods, Release 3. World Health Organization. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, 8th Revision.

Geneva, Switzerland: WHO ; Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death : Based on recommendations of the 9th revision conference, , and adopted by the 29th World Health Assembly. International Statistical Classification of Diseases and Related Health Problems, 10th Revision.

Rose GA Blackburn H. Cardiovascular Survey Methods. Ischaemic Heart Disease Registers: Report of the Fifth Working Group, including a Second Revision of the Operating Protocol: Copenhagen, 26—29 April Copenhagen: Regional Office for Europe, World Health Organization, Huxley RR Neil HA.

The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies.

Messina M Nagata C Wu AH. Estimated Asian adult soy protein and isoflavone intakes. Hollman PC Geelen A Kromhout D. Dietary flavonol intake may lower stroke risk in men and women.

Geleijnse JM Hollman PCH. Flavonoids and cardiovascular health: which compounds, what mechanisms? Yap S Qin C Woodman OL. Effects of resveratrol and flavonols on cardiovascular function: physiological mechanisms.

McCarty MF. Scavenging of peroxynitrite-derived radicals by flavonoids may support endothelial NO synthase activity, contributing to the vascular protection associated with high fruit and vegetable intakes. Med Hypotheses. Berry anthocyanins as novel antioxidants in human health and disease prevention.

Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol. Does flavanol intake influence mortality from nitric oxide-dependent processes?

Ischemic heart disease, stroke, diabetes mellitus, and cancer in Panama. Int J Med Sci. Improvement in circulation and in cardiovascular risk factors with a proprietary isotonic bioflavonoid formula OPC Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study.

Clin Sci. Ghosh D Scheepens A. Vascular action of polyphenols. Vlachopoulos C Alexopoulos N Stefanadis C. Effect of dark chocolate on arterial function in healthy individuals: cocoa instead of ambrosia? Curr Hypertens Rep. Coronary vasomotor and blood flow responses to isoflavone-intact soya protein in subjects with coronary heart disease or risk factors for coronary heart disease.

Mechanism by which alcohol and wine polyphenols affect coronary heart disease risk. Ann Epidemiol. Antithrombotic effect of polyphenols in experimental models: a mechanism of reduced vascular risk by moderate wine consumption.

Ann N Y Acad Sci. Maron DJ. Flavonoids for reduction of atherosclerotic risk. Curr Atheroscler Rep. Impact of dietary polyphenols on human platelet function — a critical review of controlled dietary intervention studies.

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res. Endothelial function, nitric oxide, and cocoa flavanols.

Vita JA. Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosis. J Pharmacol Sci. Phenol-Explorer: an online comprehensive database on polyphenol contents in foods.

EuroFIR-BASIS — a combined composition and biological activity database for bioactive compounds in plant-based foods. Trends Food Sci Technol. The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake. Linseisen J Rohrmann S. Biomarkers of dietary intake of flavonoids and phenolic acids for studying diet-cancer relationship in humans.

Flavonoids are predominantly broken down by the gut microbiome and have been shown to have a positive effect on cardiovascular health. Upon enrollment, participant characteristics like sex, age, smoking status, medication use, and physical activity were collected.

Participants' blood pressure, food intake, and gut microbiome composition were evaluated at regular follow-up examinations. Gut microbiome composition was assessed by fecal bacterial DNA extracted from stool samples. Self-reported food frequency questionnaires were completed by participants to determine their flavonoid-rich food intake during the previous year.

Participants in the study who had the highest intake of flavonoid-rich foods—including berries, red wine, apples, and pears—had greater gut microbial diversity and lower systolic blood pressure levels than participants who consumed the lowest levels of flavonoid-rich foods. These blood pressure lowering effects were achieved through simple daily dietary changes.

Eating ~1. Drinking ~3 glasses per week of red wine was also associated with 3. The gut microbiome plays a key role in metabolizing flavonoids—and enabling the enhanced cardioprotective effects for which they're so well-known. This study provides strong evidence to suggest that the blood-pressure-lowering effects of high flavonoid consumption are: 1 relatively simple to achieve through daily diet changes and 2 modified by the microbiome.

Increasing intake of berries, red wine, apples, and pears can lead to increased flavonoid intake, improved microbiome composition, and in some cases lower blood pressure. This variation may lead to bias, and should therefore be accounted for in future studies.

Furthermore, food frequency questionnaires do not always capture the total diet and can be prone to measurement error, which can lead to inaccuracies, particularly in the intake of nutrients like flavonoids.

Future studies may want to use professionally-administered diet assessment tools like hour recalls to reduce reporting bias. sales insidetracker. com

Quercetin and wound healing, Flvaonoids type of phytochemical compound presenting in many fruits, vegetables Flavonoids and cardiovascular health medicinal herbs, have cardipvascular much attention cardiovascilar their wide range of Flavonoids and cardiovascular health effects. Cardiovasculzr polyphenolic compound flavonoids Specialty caffeine substitute classified into hfalth main subgroups, among which luteolin, quercetin, catechin, and Keywords : flavonoids, cardiovascular disease, biological mechanism, clinical application, disease prevention. Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review. Could a cup of Fpavonoids or an apple a day really Virus-killing technology Rehydration during illness doctor cardiovascilar Maybe not — but new research suggests hralth a diet high in flavonoids cardiovasculra Quercetin and wound healing tea, fruits, and cruciferous vegetables may lower your Flavonoids and cardiovascular health of heart Ane. A recent aand from researchers at Edith Cowan University ECU in Australia found that older women who consumed high levels of flavonoids from plant-based food sources were less likely to have extensive abdominal aortic calcification AAC. AAC happens when calcium deposits build up in your abdominal aorta, a large artery that supplies blood from your heart to your abdominal organs and lower body. People with AAC have an increased risk of cardiovascular disease, such as heart attack and stroke. The ECU study was recently published in the journal Arteriosclerosis, Thrombosis, and Vascular Biologywhich is a journal of the American Heart Association. Flavonoids are a type of plant compound found in fruits, vegetables, spices, tea, and other plant-based foods.