Immune-boosting gut flora Immune-boostong Kara Fitzgerald, NDis a clinician researcher for the Institute for Therapeutic Discovery Immune-bolsting maintains a Immune-boostinv Immune-boosting gut flora clinic in Sandy Hook, CT. NOD2 acts as a critical regulator of the intestinal commensal microbiota, by controlling the expression and secretion of AMPs see above and suppressing the expansion of certain proinflammatory bacterial species such as Bacteroides vulgatus. Shi N, Li N, Duan X, Niu H.

Immune-boosting gut flora -

A successful translation of microbiome-based treatments into clinical practice requires standardized, stringent and unbiased preclinical and clinical intervention studies. Sender, R. Are we really vastly outnumbered? revisiting the ratio of bacterial to host cells in humans.

Cell , — Article CAS PubMed Google Scholar. Integrative HMP iHMP Research Network Consortium. The integrative human microbiome project. Nature , — Article CAS Google Scholar. Hacquard, S. et al. Microbiota and host nutrition across plant and animal kingdoms.

Cell Host Microbe 17 , — Lynch, J. Microbiomes as sources of emergent host phenotypes. Science , — Dethlefsen, L. An ecological and evolutionary perspective on human-microbe mutualism and disease. Macpherson, A. Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria.

Immunology , — Article CAS PubMed PubMed Central Google Scholar. Chu, H. Innate immune recognition of the microbiota promotes host-microbial symbiosis. Zhang, M. Interactions between intestinal microbiota and host immune response in inflammatory bowel disease.

Article PubMed PubMed Central CAS Google Scholar. Valitutti, F. Celiac disease and the microbiome. Nutrients 11 , Article CAS PubMed Central Google Scholar. Maeda, Y. Host-microbiota interactions in rheumatoid arthritis.

Article PubMed Central CAS Google Scholar. Belizario, J. Gut microbiome dysbiosis and immunometabolism: New frontiers for treatment of metabolic diseases.

Mediators Inflamm. Main, B. Microbial immuno-communication in neurodegenerative diseases. Article PubMed PubMed Central Google Scholar. Gopalakrishnan, V. The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy.

Cancer Cell 33 , — Maynard, C. Reciprocal interactions of the intestinal microbiota and immune system. Belkaid, Y. Homeostatic immunity and the microbiota. Immunity 46 , — Role of the microbiota in immunity and inflammation. Gensollen, T. How colonization by microbiota in early life shapes the immune system.

Backhed, F. Dynamics and stabilization of the human gut microbiome during the first year of life. Article PubMed CAS Google Scholar. Koenig, J. Succession of microbial consortia in the developing infant gut microbiome. USA Suppl 1 , — Yatsunenko, T. Human gut microbiome viewed across age and geography.

Russell, S. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep. Zhang, X. Unique aspects of the perinatal immune system. Bhutta, Z. Global maternal, newborn, and child health - So near and yet so far. Neu, J. Necrotizing enterocolitis.

Wang, J. Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus. Gut 67 , — Gomez de Aguero, M. The maternal microbiota drives early postnatal innate immune development. Dominguez-Bello, M. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns.

USA , — Caballero-Flores, G. Maternal immunization confers protection to the offspring against an attaching and effacing pathogen through delivery of IgG in breast milk.

Cell Host Microbe 25 , — Zheng, W. Microbiota-targeted maternal antibodies protect neonates from enteric infection. Bauer, H. The response of the lymphatic tissue to the microbial flora. Studies on germfree mice. CAS PubMed PubMed Central Google Scholar. Umesaki, Y. Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus.

Immunology 79 , 32—37 Hapfelmeier, S. Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Ivanov, I. Specific microbiota direct the differentiation of ILproducing T-helper cells in the mucosa of the small intestine.

Cell Host Microbe 4 , — Induction of intestinal Th17 cells by segmented filamentous bacteria. Tan, T. Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice.

USA , E—E Atarashi, K. Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Mazmanian, S.

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Wesemann, D. Microbial colonization influences early B-lineage development in the gut lamina propria. Cahenzli, J. Intestinal microbial diversity during early-life colonization shapes long-term IgE levels.

Cell Host Microbe 14 , — Fulde, M. Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. Mowat, A. To respond or not to respond - a personal perspective of intestinal tolerance. Konrad, A. Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota.

Gastroenterology , — Compartmentalized and systemic control of tissue immunity by commensals. Shan, M. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.

Bansal, T. The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation. Peterson, D. IgA response to symbiotic bacteria as a mediator of gut homeostasis.

Cell Host Microbe 2 , — Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Bevins, C. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Ehmann, D. Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments.

Ahuja, M. Orai1-mediated antimicrobial secretion from pancreatic acini shapes the gut microbiome and regulates gut innate immunity. Cell Metab. Rakoff-Nahoum, S. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis.

Price, A. A map of Toll-like receptor expression in the intestinal epithelium reveals distinct spatial, cell type-specific, and temporal patterns. Immunity 49 , — Carvalho, F. Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice.

Cell Host Microbe 12 , — Vijay-Kumar, M. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Ubeda, C. Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. Wen, L.

Innate immunity and intestinal microbiota in the development of type 1 diabetes. A microbial symbiosis factor prevents intestinal inflammatory disease.

Lee, Y. The protective role of Bacteroides fragilis in a murine model of colitis-associated colorectal cancer. mSphere 3 , e—18 Ramakrishna, C. Bacteroides fragilis polysaccharide A induces IL secreting B and T cells that prevent viral encephalitis.

Erturk-Hasdemir, D. Symbionts exploit complex signaling to educate the immune system. Brown, G. Dectin a signalling non-TLR pattern-recognition receptor. Tang, C. Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus -mediated regulatory T cell expansion in the intestine.

Cell Host Microbe 18 , — Bouskra, D. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Ramanan, D. Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus.

Immunity 41 , — Nigro, G. The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host Microbe 15 , — Janeway, C. Innate immune recognition.

Vaishnava, S. The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Wang, S. MyD88 adaptor-dependent microbial sensing by regulatory T cells promotes mucosal tolerance and enforces commensalism. Immunity 43 , — Broz, P.

Inflammasomes: Mechanism of assembly, regulation and signalling. Elinav, E. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Levy, M. Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling.

Wlodarska, M. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Birchenough, G. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.

Wang, P. Nlrp6 regulates intestinal antiviral innate immunity. Gálvez, E. Shaping of intestinal microbiota in Nlrp6- and Rag2-deficient mice depends on community structure. Cell Rep. Castro-Dopico, T. Anti-commensal IgG drives intestinal inflammation and type 17 immunity in ulcerative colitis.

Immunity 50 , — Seo, S. Distinct commensals induce interleukin-1beta via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury. Immunity 42 , — Wolf, A. Peptidoglycan recognition by the innate immune system.

Ratsimandresy, R. Cell Mol. Saha, S. Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma.

Cell Host Microbe 8 , — Jing, X. Peptidoglycan recognition protein 3 and Nod2 synergistically protect mice from dextran sodium sulfate-induced colitis.

Franchi, L. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Zhu, H. RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.

Cancer Res. Hornung, V. OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids. Chudnovskiy, A. Host-protozoan interactions protect from mucosal infections through activation of the inflammasome. Mosser, D. Exploring the full spectrum of macrophage activation.

Danne, C. A large polysaccharide produced by Helicobacter hepaticus induces an anti-inflammatory gene signature in macrophages. Cell Host Microbe 22 , — Schulthess, J. The short chain fatty acid butyrate imprints an antimicrobial program in macrophages.

Wu, K. Gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice. Constantinides, M. A committed precursor to innate lymphoid cells.

Gury-BenAri, M. The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome. Sonnenberg, G. Functional interactions between innate lymphoid cells and adaptive immunity. McDonald, B. Diverse developmental pathways of intestinal intraepithelial lymphocytes.

Chun, E. Metabolite-sensing receptor Ffar2 regulates colonic group 3 innate lymphoid cells and gut immunity. Immunity 51 , — Bostick, J. Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species.

Guo, X. Innate lymphoid cells control early colonization resistance against intestinal pathogens through ID2-dependent regulation of the microbiota. Rankin, L. Complementarity and redundancy of ILproducing innate lymphoid cells.

Chua, H. Intestinal dysbiosis featuring abundance of Ruminococcus gnavus associates with allergic diseases in infants. Article PubMed Google Scholar. Sterlin, D. Human IgA binds a diverse array of commensal bacteria.

Sutherland, D. Fostering of advanced mutualism with gut microbiota by immunoglobulin A. Kawamoto, S. Palm, N. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Shulzhenko, N. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut.

Nagashima, K. Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Arpaia, N. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Induction of colonic regulatory T cells by indigenous clostridium species.

Smith, P. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Hegazy, A. Miossec, P.

Targeting IL and Th17 cells in chronic inflammation. Drug Discov. Omenetti, S. The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells.

Immunity 51 , 77—89 Naik, S. Compartmentalized control of skin immunity by resident commensals. Dutzan, N. On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier.

Bedoui, S. Bachem, A. Song, X. Crotty, S. T follicular helper cell differentiation, function, and roles in disease. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut.

Proietti, M. Kubinak, J. MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health. Teng, F. Immunity 44 , — Rescigno, M. Dendritic cells shuttle microbes across gut epithelial monolayers. Immunobiology , — Martinez-Lopez, M.

Microbiota sensing by Mincle-Syk axis in dendritic cells regulates interleukin and production and promotes intestinal barrier integrity. Jie, Z. NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis.

Wingender, G. Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans. An, D. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Rothschild, D.

Environment dominates over host genetics in shaping human gut microbiota. Vojdani, A. A potential link between environmental triggers and autoimmunity. Autoimmune Dis. PubMed PubMed Central Google Scholar. Yamamoto-Hanada, K.

Influence of antibiotic use in early childhood on asthma and allergic diseases at age 5. Allergy Asthma Immunol. Becattini, S. Antibiotic-induced changes in the intestinal microbiota and disease. Trends Mol. Sato, H. Antibiotics suppress activation of intestinal mucosal mast cells and reduce dietary lipid absorption in Sprague-Dawley rats.

Scott, N. Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Kim, Y. Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE 2.

Cell Host Microbe 15 , 95— Kim, M. Ohnmacht, C. Hagan, T. Antibiotics-driven gut microbiome perturbation alters immunity to vaccines in humans. Christ, A. Western diet and the immune system: An inflammatory connection. Devkota, S. Cheng, L. High fat diet exacerbates dextran sulfate sodium induced colitis through disturbing mucosal dendritic cell homeostasis.

Haghikia, A. Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine. He, B. Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors. Rodriguez-Palacios, A. Bowel Dis. Viennois, E.

Dietary emulsifier-induced low-grade inflammation promotes colon carcinogenesis. Martinez, I. Gut microbiome composition is linked to whole grain-induced immunological improvements.

ISME J. Cignarella, F. Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota. Rangan, P. Fasting-mimicking diet modulates microbiota and promotes intestinal regeneration to reduce inflammatory bowel disease pathology.

Bishehsari, F. Abnormal eating patterns cause circadian disruption and promote alcohol-associated colon carcinogenesis. Rosshart, S. Laboratory mice born to wild mice have natural microbiota and model human immune responses.

Science , eaaw Kaplan, G. The global burden of IBD: from to Kostic, A. The microbiome in inflammatory bowel disease: current status and the future ahead. Gevers, D. Franzosa, E. Gut microbiome structure and metabolic activity in inflammatory bowel disease.

Lloyd-Price, J. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. de Souza, H. Immunopathogenesis of IBD: current state of the art. Martini, E. Mend your fences: The epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease.

Van der Sluis, M. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.

Liso, M. A specific mutation in Muc2 determines early dysbiosis in colitis-prone Winnie mice. Ogura, Y.

Hugot, J. Petnicki-Ocwieja, T. Nod2 is required for the regulation of commensal microbiota in the intestine. Cadwell, K. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.

Aden, K. ATG16L1 orchestrates interleukin signaling in the intestinal epithelium via cGAS-STING. Seregin, S. Schaubeck, M. Gut 65 , — Britton, G. Caruso, R. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation.

Torres, J. Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice. Gut 69 , 42—51 Scher, J.

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife 2 , e Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine.

Arthritis Rheumatol. Alpizar-Rodriguez, D. Prevotella copri in individuals at risk for rheumatoid arthritis. Chen, J. An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis.

Genome Med. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Wang, Q. Data-driven multiple-level analysis of gut-microbiome-immune-joint interactions in rheumatoid arthritis.

BMC Genom. Article Google Scholar. Abdollahi-Roodsaz, S. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. Rogier, R. Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL and TLR4-dependent arthritis.

Microbiome 5 , 63 Wu, H. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32 , — de Aquino, S. Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and ILdriven Th17 response.

Hotamisligil, G. Inflammation, metaflammation and immunometabolic disorders. Tilg, H. The intestinal microbiota fuelling metabolic inflammation. Kolodziejczyk, A. The role of the microbiome in NAFLD and NASH. EMBO Mol. Henao-Mejia, J. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.

Bodogai, M. Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells. Virtue, A. The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs.

Truax, A. The inhibitory innate immune sensor NLRP12 maintains a threshold against obesity by regulating gut microbiota homeostasis. Cell Host Microbe 24 , — Koeth, R. l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.

Wang, Z. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature , 57—63 Gur, C. Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack.

Mima, K. Fusobacterium nucleatum and T cells in colorectal carcinoma. JAMA Oncol. Ma, C. Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells.

Science , eaan Matson, V. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science , 97— Sivan, A. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.

Routy, B. Gut microbiome influences efficacy of PDbased immunotherapy against epithelial tumors. Science , 91—97 Vetizou, M. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Viaud, S.

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Zitvogel, L. Microbiome and anticancer immunosurveillance.

Pushalkar, S. The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov. Geller, L.

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Riquelme, E. Tumor microbiome diversity and composition influence pancreatic cancer outcomes.

Grice, E. Topographical and temporal diversity of the human skin microbiome. Oh, J. Temporal stability of the human skin microbiome.

Biogeography and individuality shape function in the human skin metagenome. Nature , 59—64 Chehoud, C. Complement modulates the cutaneous microbiome and inflammatory milieu.

Brandwein, M. Endogenous antimicrobial peptide expression in response to bacterial epidermal colonization. Commensal-dendritic-cell interaction specifies a unique protective skin immune signature. Linehan, J. Non-classical immunity controls microbiota impact on skin immunity and tissue repair.

Lai, Y. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Scharschmidt, T. A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes. Commensal microbes and hair follicle morphogenesis coordinately drive Treg migration into neonatal skin.

Cell Host Microbe 21 , — Sanford, J. Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands. Nakatsuji, T.

Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Kong, H. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis.

Genome Res. Stehlikova, Z. Dysbiosis of skin microbiota in Psoriatic patients: co-occurrence of fungal and bacterial communities.

Dialogue between skin microbiota and immunity. Nakamura, Y. Staphylococcus delta-toxin induces allergic skin disease by activating mast cells. Uluckan, O. Ichinohe, T. Microbiota regulates immune defense against respiratory tract influenza A virus infection.

Fagundes, C. Transient TLR activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree mice. Trompette, A. Immunity 48 , — Steed, A. The microbial metabolite desaminotyrosine protects from influenza through type I interferon.

Marsland, B. Host-microorganism interactions in lung diseases. Gollwitzer, E. Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Pattaroni, C. Early-life formation of the microbial and immunological environment of the human airways.

Dickson, R. The role of the microbiome in exacerbations of chronic lung diseases. Lancet , — Yadava, K. Microbiota promotes chronic pulmonary inflammation by enhancing ILA and autoantibodies.

Care Med. Segal, L. In a recent study , scientists looked at the relationships between gut microbiome diversity, diet, and the immune system in two groups of 18 people given special diets over a week period. One group ate a diet with lots of fiber, while the other was given a diet high in fermented foods containing probiotics.

Probiotics are living microbes that can have a beneficial effect on your health. The high-fiber diet was associated with stable gut diversity.

In the group that ate fermented foods, microbiome diversity increased, while markers for inflammation in the body were reduced. Other research has explored the relationship between our immune systems and the diversity of our gut microbiomes as we get older. As you age, your gut microbiome becomes less diverse and your risk of infectious disease increases.

Although further studies are required, researchers have found some evidence that both probiotics and prebiotics — substances such as fiber that feed the bacteria in your gut — could help to tackle the reduction in gut microbiome diversity.

Prebiotics can be found in foods such as:. Eat foods containing probiotics. They can help to regulate immune responses, including the functions of the gut lining. You can learn more about which foods to eat in our article on how to improve gut health.

Your gut health and your immune system are closely linked and can influence one another in a number of ways. This often involves your gut microbiome, the collection of thousands of different species of bacteria and other microorganisms that live in your gut.

Chronic inflammation is a continuing and unhealthy response from your immune system. It is associated with conditions like obesity, heart disease, and type 2 diabetes.

Research suggests that the gut microbiome may be a key player that links chronic inflammation to these diseases. Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations. Nature Communications. Gut-microbiota-targeted diets modulate human immune status.

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome.

BMC Medicine. Interaction between microbiota and immunity in health and disease. Cell Research. The intestinal microbiota fuelling metabolic inflammation. Nature Reviews Immunology.

Good metabolic health reduces your risk of metabolic syndrome and metabolic diseases, like heart disease, stro Gut microbiome tests give you a personalized profile of which microbes live in your gut and whether they are l Your lifestyle plays a powerful role in boosting energy.

Diet, exercise, stress, and sleep are the building bl Learn Nutrition Gut Health COVID Healthy Living Life Stages Health Conditions Podcasts. Gut Health Gut Microbiome. Updated 9th May Improve your gut health for a better immune system.

Immune-boosting gut flora Immune-boostting to the Probiotic Natural plant-based remedies More of a gutt learner? Watch our animation or download our infographic! Research shows that the gut plays an Immuune-boosting Immune-boosting gut flora complex and pivotal role in our overall health than we previously assumed. Beyond digestion, the gut has an impact on the functioning of our body, mind, and immune system. The immune system is defined as the network of cells, tissues and organs that work together to protect the body, helping to fight off sickness.