Gastric Bypass Surgery. Article Gwin PubMed Google Scholar Anderson JW, Patterson K. Issue Date : September Ludwig DS, Sorensen TIA.

Energy balance and weight gain -

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome—an allostatic perspective. Biochim Biophys Acta. Simmonds M, Llewellyn A, Owen CG, Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis.

Obes Rev. Guyenet SJ, Schwartz MW. Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity.

J Clin Endocrinol Metab. Hill JO, Melanson EL, Wyatt HT. Dietary fat intake and regulation of energy balance: implications for obesity.

Human obesity as a heritable disorder of the central control of energy balance. Int J Obesity. Schutz Y. Macronutrients and energy balance in obesity.

Swinburn B, Ravussin E. Energy balance or fat balance? Webber J. Energy balance in obesity. Howell S, Kones R. Am J Physiol Endocrinol Metab. Speakman JR, Hall KD. Carbohydrates, insulin, and obesity. Archer E, Pavela G, McDonald S, Lavie CJ, Hill JO. Front Physiol.

Fernandes AC, Rieger DK, Proenca RPC. Perspective: public health nutrition policies should focus on healthy eating, not on calorie counting, even to decrease obesity. Lucan SC, DiNicolantonio JJ. How calorie-focused thinking about obesity and related diseases may mislead and harm public health.

An alternative. Public Health Nutr. Mozaffarian D. Foods, obesity, and diabetes-are all calories created equal? Nutr Rev. Stenvinkel P. Obesity—a disease with many aetiologies disguised in the same oversized phenotype: has the overeating theory failed?

Nephrol Dial Transplant. Torres-Carot V, Suarez-Gonzalez A, Lobato-Foulques C. The energy balance hypothesis of obesity: do the laws of thermodynamics explain excessive adiposity? Eur J Clin Nutr.

Wells JC. Obesity as malnutrition: the dimensions beyond energy balance. Wells JC, Siervo M. Obesity and energy balance: is the tail wagging the dog? The science of obesity: what do we really know about what makes us fat? An essay by Gary Taubes. BMJ ;f Wu Y, Hu S, Yang D, Li L, Li B, Wang L, et al.

Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in Mice. Front Nutr. Tordoff MG, Ellis HT. Physiol Behav. Kennedy AR, Pissios P, Otu H, Roberson R, Xue B, Asakura K, et al.

A high-fat, ketogenic diet induces a unique metabolic state in mice. Warden CH, Fisler JS. Comparisons of diets used in animal models of high-fat feeding. Cell Metab. Buettner R, Parhofer KG, Woenckhaus M, Wrede CE, Kunz-Schughart LA, Scholmerich J, et al. Defining high-fat-diet rat models: metabolic and molecular effects of different fat types.

J Mol Endocrinol. de Moura EDM, Dos Reis SA, da Conceicao LL, Sediyama C, Pereira SS, de Oliveira LL, et al. Diet-induced obesity in animal models: points to consider and influence on metabolic markers. Diabetol Metab Syndr. Sholl J, Mailing LJ, Wood TR.

Reframing nutritional microbiota studies to reflect an inherent metabolic flexibility of the human gut: a narrative review focusing on high-fat diets.

Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.

J Neurosci. Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, et al. Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.

J Clin Invest. Cintra DE, Ropelle ER, Moraes JC, Pauli JR, Morari J, Souza CT, et al. Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity.

Oliveira V, Marinho R, Vitorino D, Santos GA, Moraes JC, Dragano N, et al. Diets containing alpha-linolenic omega3 or oleic omega9 fatty acids rescues obese mice from insulin resistance. Vijay-Kumar M, Vanegas SM, Patel N, Aitken JD, Ziegler TR, Ganji V.

Fish oil rich diet in comparison to saturated fat rich diet offered protection against lipopolysaccharide-induced inflammation and insulin resistance in mice.

Nutr Metab. Dornellas AP, Watanabe RL, Pimentel GD, Boldarine VT, Nascimento CM, Oyama LM, et al. Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions. Prostaglandins Leukot Essent Fatty Acids. Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME.

Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Ludwig DS, Ebbeling CB, Bikman BT, Johnson JD.

Testing the carbohydrate-insulin model in mice: the importance of distinguishing primary hyperinsulinemia from insulin resistance and metabolic dysfunction. Mol Metab.

Birsoy K, Festuccia WT, Laplante M. A comparative perspective on lipid storage in animals. J Cell Sci. DiAngelo JR, Birnbaum MJ. Regulation of fat cell mass by insulin in Drosophila melanogaster. Mol Cell Biol. Watts JL. Fat synthesis and adiposity regulation in Caenorhabditis elegans.

Trends Endocrinol Metab. Petro AE, Cotter J, Cooper DA, Peters JC, Surwit SJ, Surwit RS. Oscai LB, Brown MM, Miller WC.

Effect of dietary fat on food intake, growth and body composition in rats. So M, Gaidhu MP, Maghdoori B, Ceddia RB. Analysis of time-dependent adaptations in whole-body energy balance in obesity induced by high-fat diet in rats. Lipids Health Dis. Storlien LH, James DE, Burleigh KM, Chisholm DJ, Kraegen EW.

Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. Oscai LB, Miller WC, Arnall DA. Effects of dietary sugar and of dietary fat on food intake and body fat content in rats.

Reiser S, Hallfrisch J. Insulin sensitivity and adipose tissue weight of rats fed starch or sucrose diets ad libitum or in meals. Rendeiro C, Masnik AM, Mun JG, Du K, Clark D, Dilger RN, et al. Fructose decreases physical activity and increases body fat without affecting hippocampal neurogenesis and learning relative to an isocaloric glucose diet.

Sci Rep. Toida S, Takahashi M, Shimizu H, Sato N, Shimomura Y, Kobayashi I. Effect of high sucrose feeding on fat accumulation in the male Wistar rat.

Obes Res. Kabir M, Rizkalla SW, Quignard-Boulange A, Guerre-Millo M, Boillot J, Ardouin B, et al. A high glycemic index starch diet affects lipid storage-related enzymes in normal and to a lesser extent in diabetic rats.

Pawlak DB, Bryson JM, Denyer GS, Brand-Miller JC. High glycemic index starch promotes hypersecretion of insulin and higher body fat in rats without affecting insulin sensitivity. Pawlak DB, Kushner JA, Ludwig DS.

Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Scribner KB, Pawlak DB, Aubin CM, Majzoub JA, Ludwig DS. Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in mice.

Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, et al. Role of brain insulin receptor in control of body weight and reproduction. Brief DJ, Davis JD. Reduction of food intake and body weight by chronic intraventricular insulin infusion. Brain Res Bull. Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, et al.

The role of insulin receptor substrate 2 in hypothalamic and beta cell function. Tataranni PA, Gautier JF, Chen K, Uecker A, Bandy D, Salbe AD, et al. Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography.

Proc Natl Acad Sci USA. Woods SC, Lotter EC, McKay LD, Porte D Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons.

Cusin I, Rohner-Jeanrenaud F, Terrettaz J, Jeanrenaud B. Hyperinsulinemia and its impact on obesity and insulin resistance.

Int J Obes Relat Metab Disord. Terrettaz J, Cusin I, Etienne J, Jeanrenaud B. Dallon BW, Parker BA, Hodson AE, Tippetts TS, Harrison ME, Appiah MMA, et al. Insulin selectively reduces mitochondrial uncoupling in brown adipose tissue in mice.

Biochem J. Mehran AE, Templeman NM, Brigidi GS, Lim GE, Chu KY, Hu X, et al. Hyperinsulinemia drives diet-induced obesity independently of brain insulin production. Torbay N, Bracco EF, Geliebter A, Stewart IM, Hashim SA.

Insulin increases body fat despite control of food intake and physical activity. Templeman NM, Skovso S, Page MM, Lim GE, Johnson JD. A causal role for hyperinsulinemia in obesity.

J Endocrinol. Page MM, Skovso S, Cen H, Chiu AP, Dionne DA, Hutchinson DF, et al. Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain.

FASEB J. Manceau R, Majeur D, Alquier T. Neuronal control of peripheral nutrient partitioning. Yi CX, la Fleur SE, Fliers E, Kalsbeek A. The role of the autonomic nervous liver innervation in the control of energy metabolism. Munzberg H, Qualls-Creekmore E, Berthoud HR, Morrison CD, Yu S. Neural control of energy expenditure.

Handb Exp Pharmacol. Nogueiras R, Lopez M, Dieguez C. Regulation of lipid metabolism by energy availability: a role for the central nervous system. Bernard C. Leçons de physiologie expérimentale appliquée à la médecine, faites au Collège de France.

Paris: J. Baillière et fils; Book Google Scholar. Wainschtein P, Jain D, Zheng Z, TOPMed Anthropometry Working Group, NHLBI Trans-Omics for Precision Medicine TOPMed Consortium, Cupples LA.

et al. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. Nat Genet. Loos RJF, Yeo GSH. The genetics of obesity: from discovery to biology. Nat Rev Genet. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, et al.

Genetic studies of body mass index yield new insights for obesity biology. Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, et al.

Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Popkin BM, Adair LS, Ng SW. Global nutrition transition and the pandemic of obesity in developing countries. Trowell HC, Burkitt DP.

Western diseases: their emergence and prevention. London: Edward Arnold; Gross LS, Li L, Ford ES, Liu S. Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment.

Ford ES, Dietz WH. Trends in energy intake among adults in the United States: findings from NHANES. Gaesser GA, Miller Jones J, Angadi SS. Perspective: does glycemic index matter for weight loss and obesity prevention? Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB. Changes in diet and lifestyle and long-term weight gain in women and men.

Obesity - an unexplained epidemic. Freedman DS, Ford ES. Are the recent secular increases in the waist circumference of adults independent of changes in BMI? Ge L, Sadeghirad B, Ball GDC, da Costa BR, Hitchcock CL, Svendrovski A, et al.

Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials. Mansoor N, Vinknes KJ, Veierod MB, Retterstol K.

Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials. Br J Nutr. Sackner-Bernstein J, Kanter D, Kaul S.

Dietary intervention for overweight and obese adults: comparison of low-carbohydrate and low-fat diets. A meta-analysis. Tobias DK, Chen M, Manson JE, Ludwig DS, Willett W, Hu FB. Effect of low-fat diet interventions versus other diet interventions on long-term weight change in adults: a systematic review and meta-analysis.

Lancet Diabetes Endocrinol. Krieger JW, Sitren HS, Daniels MJ, Langkamp-Henken B. Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression 1. Ludwig DS, Ebbeling CB, Heymsfield SB. Improving the quality of dietary research.

Larsen TM, Dalskov SM, van Baak M, Jebb SA, Papadaki A, Pfeiffer AF, et al. Diets with high or low protein content and glycemic index for weight-loss maintenance. Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet.

Owen OE, Caprio S, Reichard GA Jr. Ketosis of starvation: a revisit and new perspectives. Clin Endocrinol Metab. Vazquez JA, Adibi SA. Protein sparing during treatment of obesity: ketogenic versus nonketogenic very low calorie diet. Horton TJ, Drougas H, Brachey A, Reed GW, Peters JC, Hill JO.

Fat and carbohydrate overfeeding in humans: different effects on energy storage. Clegg ME, Shafat A. A high-fat diet temporarily accelerates gastrointestinal transit and reduces satiety in men.

Int J Food Sci Nutr. Frahnow T, Osterhoff MA, Hornemann S, Kruse M, Surma MA, Klose C, et al. Heritability and responses to high fat diet of plasma lipidomics in a twin study.

Jansen LT, Yang N, Wong JMW, Mehta T, Allison DB, Ludwig DS, et al. Prolonged glycemic adaptation following transition from a low- to high-carbohydrate diet: a randomized controlled feeding trial. Sherrier M, Li H. The impact of keto-adaptation on exercise performance and the role of metabolic-regulating cytokines.

Ludwig DS, Dickinson SL, Henschel B, Ebbeling CB, Allison DB. Do lower-carbohydrate diets increase total energy expenditure?

An updated and reanalyzed meta-analysis of 29 controlled-feeding studies. Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, et al.

Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake. Hall KD, Guo J, Courville AB, Boring J, Brychta R, Chen KY, et al. Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake.

Nat Med. Cahill GF Jr. The Banting Memorial Lecture Physiology of insulin in man. Cheng AYY, Zinman B. Principles of insulin therapy. In: Kahn CR, Weir GC, King GL, Moses AC, Smith RJ, Jacobson AM, editors.

Huang Z, Wang W, Huang L, Guo L, Chen C. Suppression of insulin secretion in the treatment of obesity: a systematic review and meta-analysis. Cai X, Han X, Luo Y, Ji L. Comparisons of the efficacy of alpha glucosidase inhibitors on type 2 diabetes patients between Asian and Caucasian.

Istfan N, Hasson B, Apovian C, Meshulam T, Yu L, Anderson W, et al. Acute carbohydrate overfeeding: a redox model of insulin action and its impact on metabolic dysfunction in humans.

Bikman BT, Shimy KJ, Apovian CM, Yu S, Saito ER, Walton CM, et al. A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration.

Flint A, Raben A, Ersboll AK, Holst JJ, Astrup A. The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity.

Rosenstock J, Hanefeld M, Shamanna P, Min KW, Boka G, Miossec P, et al. Beneficial effects of once-daily lixisenatide on overall and postprandial glycemic levels without significant excess of hypoglycemia in type 2 diabetes inadequately controlled on a sulfonylurea with or without metformin GetGoal-S.

J Diabetes Complications. van Can J, Sloth B, Jensen CB, Flint A, Blaak EE, Saris WH. Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults.

Int J Obes. Makimura H, Stanley TL, Suresh C, De Sousa-Coelho AL, Frontera WR, Syu S, et al. Metabolic effects of long-term reduction in free fatty acids with acipimox in obesity: a randomized trial. Fery F, Plat L, Baleriaux M, Balasse EO.

Inhibition of lipolysis stimulates whole body glucose production and disposal in normal postabsorptive subjects. Friedman MI, Harris RB, Ji H, Ramirez I, Tordoff MG. Fatty acid oxidation affects food intake by altering hepatic energy status. Friedman MI, Tordoff MG. Fatty acid oxidation and glucose utilization interact to control food intake in rats.

Horn CC, Ji H, Friedman MI. Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats. Kahler A, Zimmermann M, Langhans W. Suppression of hepatic fatty acid oxidation and food intake in men. Nutrition ;— Leonhardt M, Langhans W. Fatty acid oxidation and control of food intake.

Swithers SE, McCurley M, Scheibler A, Doerflinger A. Differential effects of lipoprivation and food deprivation on chow and milk intake in and day-old rats. Anderson JW, Patterson K. J Am Coll Nutr. Fister K. PubMed PubMed Central Google Scholar. Harris JL, Graff SK.

Protecting young people from junk food advertising: implications of psychological research for First Amendment law. Am J Public Health. Jensen ML, Schwartz MB. Junk food consumption trends point to the need for retail policies. Lobstein T, Davies S. Bell EA, Castellanos VH, Pelkman CL, Thorwart ML, Rolls BJ.

Energy density of foods affects energy intake in normal-weight women. Ello-Martin JA, Roe LS, Ledikwe JH, Beach AM, Rolls BJ. Dietary energy density in the treatment of obesity: a year-long trial comparing 2 weight-loss diets.

Rolls BJ, Roe LS, Beach AM, Kris-Etherton PM. Provision of foods differing in energy density affects long-term weight loss.

Saquib N, Natarajan L, Rock CL, Flatt SW, Madlensky L, Kealey S, et al. The impact of a long-term reduction in dietary energy density on body weight within a randomized diet trial.

Nutr Cancer. Ledikwe JH, Rolls BJ, Smiciklas-Wright H, Mitchell DC, Ard JD, Champagne C, et al. Reductions in dietary energy density are associated with weight loss in overweight and obese participants in the PREMIER trial.

Bes-Rastrollo M, van Dam RM, Martinez-Gonzalez MA, Li TY, Sampson LL, Hu FB. Prospective study of dietary energy density and weight gain in women. Blundell JE, MacDiarmid JI. Fat as a risk factor for overconsumption: satiation, satiety, and patterns of eating.

Hill JO, Prentice AM. Sugar and body weight regulation. discussion 73SS. Golay A, Bobbioni E. The role of dietary fat in obesity. PubMed Google Scholar. Rolls BJ, Shide DJ. The influence of dietary fat on food intake and body weight. McGinnis JM, Nestle M. Howard BV, Manson JE, Stefanick ML, Beresford SA, Frank G, Jones B, et al.

Look AHEAD Research Group, Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.

Luepker RV, Perry CL, McKinlay SM, Nader PR, Parcel GS, Stone EJ, et al. The Child and Adolescent Trial for Cardiovascular Health. CATCH collaborative group. Mozaffarian D, Ludwig DS. The US dietary guidelines: lifting the ban on total dietary fat.

Poti JM, Braga B, Qin B. Ultra-processed food intake and obesity: what really matters for health-processing or nutrient content? Stunkard A, McLaren-Hume M. The results of treatment for obesity: a review of the literature and report of a series.

AMA Arch Intern Med. Goodrick GK, Poston WS 2nd, Foreyt JP. Methods for voluntary weight loss and control: update Methods for voluntary weight loss and control.

NIH technology assessment conference panel. Ann Intern Med. Jou C. J Gilde Age Progressive Era. La Berge AF. How the ideology of low fat conquered america. J Hist Med Allied Sci.

Apolzan JW, Bray GA, Smith SR, de Jonge L, Rood J, Han H, et al. Effects of weight gain induced by controlled overfeeding on physical activity. Norgan NG, Durnin JV. Public Health Nutr 7 1a — Article CAS PubMed Google Scholar. James P et al Ending malnutrition by an agenda for change in the Millennium.

UN SCN, Geneva. Moubarac JC, Martins AP, Claro RM, Levy RB, Cannon G, Monteiro CA Consumption of ultra-processed foods and likely impact on human health. Evidence from Canada. Public Health Nutr 16 12 — Monteiro CA, Levy RB, Claro RM, de Castro IR, Cannon G Increasing consumption of ultra-processed foods and likely impact on human health: evidence from Brazil.

Public Health Nutr 14 1 :5— Baker P, Friel S Processed foods and the nutrition transition: evidence from Asia.

Obes Rev 15 7 — Barquera S, Pedroza-Tobias A, Medina C Cardiovascular diseases in mega-countries: the challenges of the nutrition, physical activity and epidemiologic transitions, and the double burden of disease.

Curr Opin Lipidol 27 4 — Article CAS PubMed PubMed Central Google Scholar. International Food Policy Research Institute Global nutrition report actions and accountability to advance nutrition and sustainable development.

Washington, DC. Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K et al Body fatness and cancer—viewpoint of the IARC Working Group. N Engl J Med 8 — Hanahan D, Weinberg RA Hallmarks of cancer: the next generation. Cell 5 — Bonomini F, Rodella LF, Rezzani R Metabolic syndrome, aging and involvement of oxidative stress.

Aging disease 6 2 — Hursting SD, Berger NA Energy balance, host-related factors, and cancer progression. J Clin Oncol 28 26 — Renehan AG, Roberts DL, Dive C Obesity and cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem 1 — Sun Q, van Dam RM, Spiegelman D, Heymsfield SB, Willett WC, Hu FB Comparison of dual-energy X-ray absorptiometric and anthropometric measures of adiposity in relation to adiposity-related biologic factors.

Am J Epidemiol 12 — World Health Organization Waist circumference and waist-hip ratio: a report of a WHO expert consultation. van der Kooy K, Leenen R, Seidell JC, Deurenberg P, Droop A, Bakker CJ Waist-hip ratio is a poor predictor of changes in visceral fat. Am J Clin Nutr 57 3 — PubMed Google Scholar.

Willett W. Implications of total energy intake for epidemiologic analyses. Nutritional epidemiology. Oxford University Press, New York, pp — Heymsfield SB, Lohman TG, Wang Z, Going SB Human body composition.

McCrory MA, Gomez TD, Bernauer EM, Mole PA Evaluation of a new air displacement plethysmograph for measuring human body composition. Med Sci Sports Exerc 27 12 — Glickman SG, Marn CS, Supiano MA, Dengel DR Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposity.

J Appl Physiol 97 2 — Article Google Scholar. Bandera EV, Maskarinec G, Romieu I, John EM Racial and ethnic disparities in the impact of obesity on breast cancer risk and survival: a global perspective. Adv Nutr 6 6 — Scientific Advisory Committee on Nutrition Dietary reference values for energy.

The Stationery Office, London. Hall KD, Sacks G, Chandramohan D, Chow CC, Wang YC, Gortmaker SL et al Quantification of the effect of energy imbalance on bodyweight. Healy GN, Wijndaele K, Dunstan DW, Shaw JE, Salmon J, Zimmet PZ et al Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study AusDiab.

Diabetes Care 31 2 — Romero-Corral A, Somers VK, Sierra-Johnson J, Thomas RJ, Collazo-Clavell ML, Korinek J et al Accuracy of body mass index in diagnosing obesity in the adult general population. Int J Obes Lond 32 6 — Article CAS Google Scholar. Ello-Martin JA, Ledikwe JH, Rolls BJ The influence of food portion size and energy density on energy intake: implications for weight management.

Am J Clin Nutr 82 1 Suppl S— S. Prentice AM Manipulation of dietary fat and energy density and subsequent effects on substrate flux and food intake. Am J Clin Nutr 67 3 Suppl S— S. Fogelholm M, Anderssen S, Gunnarsdottir I, Lahti-Koski M Dietary macronutrients and food consumption as determinants of long-term weight change in adult populations: a systematic literature review.

Food Nutr Res Salas-Salvado J, Bullo M, Babio N, Martinez-Gonzalez MA, Ibarrola-Jurado N, Basora J et al Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial.

Diabetes Care 34 1 — Jaworowska A, Blackham T, Davies IG, Stevenson L Nutritional challenges and health implications of takeaway and fast food. Nutr Rev 71 5 — Schroder H, Fito M, Covas MI Association of fast food consumption with energy intake, diet quality, body mass index and the risk of obesity in a representative Mediterranean population.

Br J Nutr 98 6 — Pereira MA, Kartashov AI, Ebbeling CB, Van Horn L, Slattery ML, Jacobs DR Jr. Alkerwi A, Crichton GE, Hebert JR Consumption of ready-made meals and increased risk of obesity: findings from the observation of cardiovascular risk factors in Luxembourg ORISCAV-LUX study.

Br J Nutr 1—8. Kant AK, Whitley MI, Graubard BI Away from home meals: associations with biomarkers of chronic disease and dietary intake in American adults, NHANES — Int J Obes Lond 39 5 — Chajes V, Biessy C, Ferrari P, Romieu I, Freisling H, Huybrechts I et al Plasma elaidic acid level as biomarker of industrial trans fatty acids and risk of weight change: report from the EPIC study.

PloS one 10 2 :e Han E, Powell LM Consumption patterns of sugar-sweetened beverages in the United States. J Acad Nutr Dietetics 1 — Basu S, McKee M, Galea G, Stuckler D Relationship of soft drink consumption to global overweight, obesity, and diabetes: a cross-national analysis of 75 countries.

Am J Public Health 11 — Malik VS, Pan A, Willett WC, Hu FB Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr 98 4 — Te Morenga L, Mallard S, Mann J Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies.

BMJ e Rouhani MH, Salehi-Abargouei A, Surkan PJ, Azadbakht L Is there a relationship between red or processed meat intake and obesity? A systematic review and meta-analysis of observational studies. Obes Rev 15 9 — Fung TT, Pan A, Hou T, Chiuve SE, Tobias DK, Mozaffarian D et al Long-term change in diet quality is associated with body weight change in men and women.

J Nutr 8 — Romaguera D, Norat T, Vergnaud AC, Mouw T, May AM, Agudo A et al Mediterranean dietary patterns and prospective weight change in participants of the EPIC-PANACEA project. Am J Clin Nutr 92 4 — Funtikova AN, Benitez-Arciniega AA, Gomez SF, Fito M, Elosua R, Schroder H Mediterranean diet impact on changes in abdominal fat and year incidence of abdominal obesity in a Spanish population.

Br J Nutr 8 — Buckland G, Bach A, Serra-Majem L Obesity and the Mediterranean diet: a systematic review of observational and intervention studies.

Obes Rev Off J Int Assoc Study Obes 9 6 — Richter LM, Victora CG, Hallal PC, Adair LS, Bhargava SK, Fall CH et al Cohort profile: the consortium of health-orientated research in transitioning societies.

Int J Epidemiol 41 3 — Int J Epidemiol. Romieu I, Escamilla-Nunez MC, Sanchez-Zamorano LM, Lopez-Ridaura R, Torres-Mejia G, Yunes EM et al The association between body shape silhouette and dietary pattern among Mexican women. Public Health Nutr 15 1 — Scientific Advisory Committee on Nutrition Carbohydrates and health.

Mirza NM, Palmer MG, Sinclair KB, McCarter R, He J, Ebbeling CB et al Effects of a low glycemic load or a low-fat dietary intervention on body weight in obese Hispanic American children and adolescents: a randomized controlled trial.

Am J Clin Nutr 97 2 — Tobias DK, Chen M, Manson JE, Ludwig DS, Willett W, Hu FB Effect of low-fat diet interventions versus other diet interventions on long-term weight change in adults: a systematic review and meta-analysis.

Lancet Diabetes. Endocrinol 3 12 — Hu T, Mills KT, Yao L, Demanelis K, Eloustaz M, Yancy WS Jr. Am J Epidemiol Suppl 7 :S44—S Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK et al American College of Sports Medicine Position Stand.

Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults.

Med Sci Sports Exerc 41 2 — Thorogood A, Mottillo S, Shimony A, Filion KB, Joseph L, Genest J et al Isolated aerobic exercise and weight loss: a systematic review and meta-analysis of randomized controlled trials. Am J Med 8 — Miller CT, Fraser SF, Levinger I, Straznicky NE, Dixon JB, Reynolds J et al The effects of exercise training in addition to energy restriction on functional capacities and body composition in obese adults during weight loss: a systematic review.

PloS one 8 11 :e Ismail I, Keating SE, Baker MK, Johnson NA A systematic review and meta-analysis of the effect of aerobic vs. resistance exercise training on visceral fat. Obes Rev Off J Int Assoc Study Obesity 13 1 — PLoS One 8 12 :e Hu FB, Li TY, Colditz GA, Willett WC, Manson JE Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women.

Jama 14 — Liao Y, Liao J, Durand CP, Dunton GF Which type of sedentary behaviour intervention is more effective at reducing body mass index in children? A meta-analytic review. Obes Rev Off J Int Assoc Study Obesity 15 3 — Blundell JE, Gibbons C, Caudwell P, Finlayson G, Hopkins M Appetite control and energy balance: impact of exercise.

ObesRev 16 Suppl 1 — Franks PW, Ravussin E, Hanson RL, Harper IT, Allison DB, Knowler WC et al Habitual physical activity in children: the role of genes and the environment.

Am J Clin Nutr 82 4 — CAS PubMed Google Scholar. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR et al Genetic studies of body mass index yield new insights for obesity biology.

Nature — Ahmad S, Varga TV, Franks PW Gene x environment interactions in obesity: the state of the evidence. Hum Hered 75 2—4 — Kilpelainen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E et al Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of , adults and 19, children.

PLoS Med 8 11 :e Qi Q, Chu AY, Kang JH, Jensen MK, Curhan GC, Pasquale LR et al Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med 15 — Diabetologia 57 3 — Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T et al Gene x dietary pattern interactions in obesity: analysis of up to 68, adults of European ancestry.

Hum Mol Genet 24 16 — van Dijk SJ, Tellam RL, Morrison JL, Muhlhausler BS, Molloy PL Recent developments on the role of epigenetics in obesity and metabolic disease.

Clinical Epigenetics 7 1 Chambers JC, Loh M, Lehne B, Drong A, Kriebel J, Motta V et al. Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case—control study.

Lancet Diabetes Endocrinol 3 7 — Dick KJ, Nelson CP, Tsaprouni L, Sandling JK, Aïssi D, Wahl S et al. DNA methylation and body-mass index: a genome-wide analysis.

Blottiere HM, de Vos WM, Ehrlich SD, Dore J Human intestinal metagenomics: state of the art and future. Curr Opin Microbiol 16 3 — Vangay P, Ward T, Gerber JS, Knights D Antibiotics, pediatric dysbiosis, and disease. Cell Host Microbe 17 5 — Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G et al Richness of human gut microbiome correlates with metabolic markers.

Dao MC, Everard A, Aron-Wisnewsky J, Sokolovska N, Prifti E, Verger EO et al Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology.

Gut 65 3 — Kong LC, Holmes BA, Cotillard A, Habi-Rachedi F, Brazeilles R, Gougis S et al Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects.

PLoS One 9 10 :e Lobstein T, Baur L, Uauy R, TaskForce IIO Obesity in children and young people: a crisis in public health. Obes Rev 5 Suppl 1 :4— Perez-Morales E, Bacardi-Gascon M, Jimenez-Cruz A Sugar-sweetened beverage intake before 6 years of age and weight or BMI status among older children; systematic review of prospective studies.

Nutr Hosp 28 1 — JAMA 16 — Fatima Y, Doi SAR, Mamun AA Longitudinal impact of sleep on overweight and obesity in children and adolescents: a systematic review and bias-adjusted meta-analysis. Obes Rev 16 2 — WHO Global strategy on diet, physical activity and health—what are the causes?

World Health Organization. International Society for Developmental Origins of Health and Disease. Tie HT, Xia YY, Zeng YS, Zhang Y, Dai CL, Guo JJ et al Risk of childhood overweight or obesity associated with excessive weight gain during pregnancy: a meta-analysis. Arch Gynecol Obstet 2 — Norris SA, Osmond C, Gigante D, Kuzawa CW, Ramakrishnan L, Lee NR et al Size at birth, weight gain in infancy and childhood, and adult diabetes risk in five low- or middle-income country birth cohorts.

Diabetes Care 35 1 — Adair LS, Martorell R, Stein AD, Hallal PC, Sachdev HS, Prabhakaran D et al Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter?

Am J Clin Nutr 89 5 — de Beer M, Vrijkotte TG, Fall CH, van Eijsden M, Osmond C, Gemke RJ Associations of infant feeding and timing of linear growth and relative weight gain during early life with childhood body composition.

Int J Obes Lond 39 4 — Papadimitriou A Timing of adiposity rebound and prevalence of obesity. J Pediatr 2 Weng SF, Redsell SA, Swift JA, Yang M, Glazebrook CP Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy.

Arch Dis Child 97 12 — Pearce J, Taylor MA, Langley-Evans SC Timing of the introduction of complementary feeding and risk of childhood obesity: a systematic review.

Int J Obesity 37 10 — Wilson SM, Sato AF Stress and paediatric obesity: what we know and where to go Stress. Health London 30 2 — Cecchini M, Sassi F, Lauer JA, Lee YY, Guajardo-Barron V, Chisholm D. Tackling of unhealthy diets, physical inactivity, and obesity: health effects and cost-effectiveness.

Gortmaker SL, Long MW, Resch SC, Ward ZJ, Cradock AL, Barrett JL et al Cost effectiveness of childhood obesity interventions: evidence and methods for CHOICES. Am J Prev Med 49 1 — Pan American Health Organization Recommendations from a Pan American Health Organization Expert Consultation on the Marketing of Food and Non-Alcoholic Beverages to Children in the Americas.

PAHO, Washington, D. Jenkin G, Madhvani N, Signal L, Bowers S A systematic review of persuasive marketing techniques to promote food to children on television.

Obes Rev 15 4 — Hawkes C Regulating and litigating in the public interest: regulating food marketing to young people worldwide: trends and policy drivers.

Am J Public Health 97 11 — Wang YWY, Wilson RF, Bleich S, Cheskin L, Weston C, Showell N, Fawole O, Lau B, Segal J Childhood obesity prevention programs: comparative effectiveness review and meta-analysis internet: agency for healthcare research and quality US ; Contract No.

USDA Nutrition Evidence Library NEL Dietary patterns systematic review. UK Scientific Advisory Committee on Nutrition The influence of maternal, fetal and child nutrition on development of chronic disease in later life.

Emmett PM, Jones LR Diet, growth, and obesity development throughout childhood in the Avon Longitudinal Study of Parents and Children. Nutr Rev 73 Suppl 3 — Victora CG, Adair L, Fall C, Hallal PC, Martorell R, Richter L et al Maternal and child undernutrition: consequences for adult health and human capital.

Yang Z, Huffman SL Nutrition in pregnancy and early childhood and associations with obesity in developing countries. Health Care. Energy Balance and Weight Management. October 23, Authored by: AdventHealth Foundation Central Florida.

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Anr O. The intent of Electrolyte Homeostasis paper Eneergy Energy balance and weight gain address the obesity epidemic, which is a term used Electrolyte Homeostasis describe Healthy and Natural Power sudden and rapid increase in obesity Energy balance and weight gain that began in the weiggt and continues unabated today. Sincethe entire population, regardless of starting weight, is gradually gaining weight. This has led to escalating obesity rates and to obesity being considered one of the most serious public health challenges facing the world. At one level, the obesity epidemic is a classic gene-environment interaction where the human genotype is susceptible to environmental influences that affect energy intake and energy expenditure. It is also a problem of energy balance.

Sunmi Yoo. Department of Family Medicine, Inje University Haeundae Paik Hospital, Busan, Korea. Dynamic energy balance can give Forskolin and mood enhancement important answers for why obesity is so resistant to control.

When food intake is reduced for weight control, all components of energy expenditure change, including Enrgy rate gxin rest resting energy expenditure [REE]metabolic rate of exercise, and weihht thermogenesis.

This means that a Sugar-free options in energy balahce influences energy expenditure in a dynamic way. Mechanisms associated with reduction balande total energy yain following weight loss Social anxiety relief strategies likely to be related to decreased vain mass and enhanced metabolic efficiency.

Reducing calorie intake results in a decrease in body weight, initially with gwin marked gxin in fat weignt mass Skin-loving plant extracts a decrease in REE, and this change is maintained weighht several wegiht in a weigyt state.

Metabolic Turmeric for memory improvement, which is not explained Energg changes in body composition, lasts Probiotics for digestion more than several years.

These are weibht physiological bwlance that induce weight regain. To avoid a typically observed weight-loss and regain trajectory, realistic weight loss goals Enervy be established and maintained for more than Enerrgy year. Using a mathematical Eneggy can help clinicians formulate advice about diet control.

Balznce is important to emphasize steady efforts for several amd to maintain reduced weight over efforts to lose weight. Because obesity bain difficult to reverse, clinicians must prioritize obesity prevention, Energy balance and weight gain.

Incorporating restrictions and goals prevention strategies should have high feasibility, broad population Endrgy, and relatively low cost, especially for young children who have the smallest energy gaps balancee change.

Overweight and obesity have been increasing Eneegy for several decades. Inbaoance than million children and million adults worldwide were obese. Snd interventions such as healthy diet and increased physical activity have been widely recommended to reduce the gai of obesity-related complications as well as obesity itself.

While these interventions are the basis of baalance for obesity, it vain hard Electrolyte Homeostasis demonstrate that they can effectively manage obesity. Although several medications approved for chronic weighf management can be Organic baby products for patients who have been Electrolyte Homeostasis with diet and Enregy alone, bariatric surgery may balsnce the Energy balance and weight gain effective intervention Performance meal timing weight Energgy, disease gaiin, and Ennergy thus far.

If we are to effectively prevent and treat obesity, weigjt is essential to rethink why obesity is so resistant to treatment and to gain a better understanding of energy homeostasis, which is one of Ehergy reasons why voluntary weight loss is OMAD weight loss results difficult to achieve and maintain.

Weigut aims of Electrolyte Homeostasis narrative review are baalance to understand recent research results about dynamic energy balance, 2 to apply this research Proven Fat Burning Ingredients clinical practice of Electrolyte Homeostasis treatment in terms of body compositional change, and 3 to estimate the change in dynamic Enefgy balance for Recovery aids for seniors control.

Reducing energy intake for weight control causes a negative energy wwight, which balnce that Quinoa taco salad intake is weighf than energy expenditure. There are agin views on the relationship Electrolyte Homeostasis the sides of the energy wfight equation.

Static or linear energy balance simply assumes that a change in energy intake does not change or influence Protein and immune function expenditure. Weoght the other hand, dynamic or nonlinear energy balance assumes that numerous biological and behavioral factors Energy balance and weight gain and influence both sides of the energy weigght equation.

Thus, a balancs in factors related to energy intake can and balahce influence wejght related to energy expenditure. In reality, Enerby food intake for weight Antioxidant-Rich Bone Health changes all aspects of energy expenditure, including metabolic rate at rest, metabolic rate of exercise, and adaptive thermogenesis AT.

A typical misconception associated with static energy balance is the so-called 3,kcal rule. On the other hand, the dynamic models result in a curvilinear pattern of weight Nutritious cooking oils over time and depend gian age, sex, height, baseline weight, and degree Enwrgy caloric restriction, according to the first law of thermodynamics.

Recently, weighf mathematical models weighr dynamic energy balabce have helped more accurately predict body weight changes in response to changes in energy Endrgy and expenditure. They include Enegy model Enrrgy by Hall et al.

For example, the model developed by Low-calorie beverages et al. Amino acid availability is weigght metabolically ad component of the body, i. Most of these changes take Enerty passively Electrolyte Homeostasis are nonadaptive.

However, balwnce mentioned earlier, weight change does not exactly follow the prediction based on calculation of energy imbalance. This is explained by FFM-independent metabolic adaptations, i.

The total energy expenditure TEE of the human body is composed of resting energy expenditure REEthat is, energy needed to fuel cellular function; non-REE, or energy expended during physical activity; and diet-induced thermogenesis DITor the thermal effect of feeding, that is, the energy needed to process ingested food.

Non-REE is an activity-related component including exercise and non-exercise activity thermogenesis. AT refers to changes in REE and non-REE, which are independent from changes in FFM and its composition.

Individuals with normal weight maintain their energy balance over a period of time in a remarkably accurate way. For example, a healthy adult weighing 75 kg typically consumes 3, kcal every day i.

One study demonstrated that recording food intake for 2 weeks revealed interesting findings; compensatory intake occurred with a lag time of 3 to 4 days when more than the average energy intake was consumed.

It is also possible to examine the trend of food intake over a long period of time. The Food and Agriculture Organization of the United Nations calculated that the average American consumes more than 3, kcal a day, or a total of 1.

Department of Agriculture calculates that a sedentary adult male requires 2, kcal a day, orkcal a year, and those who are physically active require 2, kcal a day, an annual intake of 1.

Without the intervention of compensatory mechanisms, this significant excess of energy intake over expenditure would result in a massive increase in body weight every year.

Therefore, the mismatch in energy balance on a day-to-day basis is corrected by the energy homeostasis system over long periods of time. Two models have dominated the discussion regarding the mechanisms by which body weight is regulated between energy intake and expenditure.

The set point model suggests that there is an active feedback mechanism linking adipose tissue stored energy to food intake and expenditure via a set point, presumably encoded in the brain. The biological mechanisms that control energy balance are programmed by environmental factors, and the point at which body weight is maintained may change.

In this system, the level of the energy reservoir fat stores settles to an equilibrium that is determined by inflow food intakewhich is matched to outflow energy expenditureas the rate of outflow is passively related to the level of the reservoir.

Hence, the settling point model explains the increasing prevalence of obesity as a result of food availability, more exposure to food signals i. There is no doubt that changes in the availability of food and its increased caloric content have played a major role in the obesity epidemic.

However, public health advice to reduce food intake has not provided a fundamental solution in resolving obesity. Although high calorie intake was an important cause of the problem initially, its reduction is not able to solve it. Reducing calorie intake results in a decrease in body weight, followed by strong physiological adaptations to regain weight.

According to dynamic energy balance, weight loss results from a negative energy balance and changes in body composition Fig. It is not continuous but ends in a curvilinear way when a new equilibrium between energy intake and energy expenditure is reached. During caloric restriction, the first phase of weight loss is rapid and lasts from a few days to a month phase 1 ; this is followed by a second phase characterized by a slower weight loss phase 2.

AT is observed in lean as well as overweight subjects, independent of the weight loss strategy. During phase 1, more FFM decreases than fat mass. During the first week of caloric restriction, hepatic glycogen stores are depleted due to an immediate drop in insulin secretion, resulting in natriuresis and a reduction in extracellular water.

A negative nitrogen balance from protein loss results primarily from gastrointestinal tract and liver proteins involved with nutrient processing in the early phase of weight loss.

Later, proteolysis occurs in skeletal muscle and other visceral organs. Thus, water associated with protein catabolism is an important contributor to the rapid weight loss observed in phase 1. The combined effects of glycogen, protein, and fluid loss largely account for the rapid weight loss of phase 1 compared with the slower rates observed in phase 2.

Results indicate that regulation of AT occurred mainly during phase 1 because the AT became manifest within the first 3 days after caloric restriction, with no further changes during phase 2. After a decrease in body weight, the AT decreased with leptin reduction due to body fat depletion.

TEE also remained lower due to reduced AT in the non-REE; it was accompanied by increased skeletal muscle work efficiency and decreased plasma levels of leptin and T3 associated with low sympathetic nervous system activity.

It is possible to obtain important information about changes in body composition and energy expenditure after dramatic weight loss from the results of an American competition reality show. After that, it was recommended that they continue eating and exercise interventions at the same level back at home.

At week 30, all participants were tested for body composition and energy expenditure, i. On average, participants lost more than one-third of their initial body weight initial mean BMI, Participants who rapidly lost a significant amount of weight through diet restriction and vigorous physical activity preserved much of their FFM.

Relative preservation of FFM was likely due to maintenance or possible increase of skeletal muscle tissue during vigorous exercise. A substantial decrease in resting metabolism during active weight loss might not be avoided by the addition of an exercise program.

Suppression of resting metabolism continued after 6 years of competition, despite substantial weight regains. On the other hand, the magnitude of metabolic adaptation increased 6 years after the competition.

Therefore, long-term weight loss requires vigilant combat against persistent metabolic adaptation that acts to proportionally counter ongoing efforts to reduce body weight.

Analysis using the computational model of metabolism by Hall et al. Metabolic adaptation occurs in energy expenditure even when individuals attempt to lose weight by exercise alone without diet control.

Thus, both energy expenditure and energy intake were affected by adaptive metabolic response to weight loss due to exercise. Thus, weight loss, whether diet-induced or exercise-driven, leads to decrease in TEE, REE, and non-REE.

Mechanisms associated with reduction of TEE following weight loss are likely to be related to decreased body mass and enhanced metabolic efficiency. Using a mathematical model that reflects dynamic energy balance, it is possible to make personalized calorie and physical activity plans to reach a goal weight within a specific time period and to maintain it afterward.

By modifying the initial conditions of the model to represent an individual person, the simulator can be used for personalized goal setting and behavioral intervention planning. In reality, however, outpatient weight-loss interventions typically result in maximum weight loss after 6 to 8 months, followed by gradual weight regain over subsequent years.

A common explanation for the weight loss plateau at 6 to 8 months is that energy expenditure decreases to match energy intake, pausing further weight loss metabolic compensation. Weight regain occurs as individuals gradually weaken compliance with the diet that has resulted in weight loss behavioral compensation.

Hall et al. Energy intake gradually increased and returned to the original weight-maintenance level in the first year and was maintained there for the remaining 3-year simulation.

The simulated TEE showed that negative energy balance was achieved for less than 8 months, after which positive energy balance and weight regain occurred. This predicted pattern of energy intake means that weight loss continues for several months at the same time that average energy intake slowly increases.

The dieter may then misconstrue that maintenance of lifestyle change is not essential for continuing weight loss when weight regain has already begun. Even if the original lifestyle is resumed within the first year, the weight gain will gradually recur over many years because weight change occurs slowly.

As mentioned earlier, energy intake and expenditure are tightly coupled over prolonged time intervals in adults living independently. This is equivalent to an average increase of energy stored in body fat and lean tissue divided by the time needed to store the energy. As these changes have persisted for the last three decades, the obesity epidemic has become a global problem.

The maintenance energy gap estimates the increased energy intake needed to maintain higher average weights following the obesity epidemic.

: Energy balance and weight gain

What is Energy Balance and Obesity?	Diabetes Obes Metab. Salas-Salvado J, Bullo M, Babio N, Martinez-Gonzalez MA, Ibarrola-Jurado N, Basora J et al Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Article CAS PubMed Google Scholar Hetherington AW, Ranson SW. Fruit consumption and adiposity status in adults: A systematic review of current evidence. van Can J, Sloth B, Jensen CB, Flint A, Blaak EE, Saris WH. Stubbs RJ , Ritz P , Coward WA , Prentice AM Covert manipulation of the ratio of dietary fat to carbohydrate and energy density: effect on food intake and energy balance in free-living men eating ad libitum.
Dynamic Energy Balance and Obesity Prevention	We recommended Energy balance and weight gain use of inexpensive snd counters or Cholesterol reducing supplements to allow people to Energy balance and weight gain goals and monitor progress ad increased walking. Hall KD, Guo J. Energy intake and expenditure A regular supply of dietary abd is essential for life and is required to fuel many different body processes. Both models target these highly processed carbohydrates—albeit for different reasons—as major drivers of weight gain. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Clinical translation and public adoption Both sides of this debate agree that fundamental changes in the food environment have driven the obesity pandemic. Obes Rev ;e
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models	Article Weiht PubMed Google Energy balance and weight gain balanxe Moura EDM, Dos Reis SA, da Conceicao Electrolyte Homeostasis, Sediyama C, Pereira SS, de Oliveira LL, et Hydration and injury prevention in sports. Wu Y, Hu Balane, Yang D, Li Blaance, Li Abd, Energy balance and weight gain L, balacne al. LCC is founder of Faeth Therapeutics, a company that generates diets to enhance responses to cancer drugs. Article CAS PubMed Google Scholar Torres-Carot V, Suarez-Gonzalez A, Lobato-Foulques C. However, there are exceptions; for example, nuts and olive oil both extremely energy dense did not increase weight when added to a diet [ 39 ]. Ello-Martin JA, Ledikwe JH, Rolls BJ The influence of food portion size and energy density on energy intake: implications for weight management.
Changing Your Energy Balance to Help Lose Weight	Article PubMed Google Scholar van Can J, Sloth B, Jensen CB, Flint A, Blaak EE, Saris WH. The more we focus on calories and dietary restraint as a society. Potentially reversible epigenetic changes in particular altered DNA methylation patterns could also serve as biomarkers of energy balance and mediators of gene—environment interaction in obesity [ 77 ]. USDA Nutrition Evidence Library NEL Dietary patterns systematic review. Laparoscopic Sleeve Gastrostomy. This is a very long-term strategy for first stopping and then reversing the escalating obesity rates, but one that can, over time, return obesity rates to pres levels.

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