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Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells.

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Download references. B and M. P were funded by the Rachadapisek Sompote Fund for Postdoctoral Fellowship, Chulalongkorn University. M was funded by The Second Century Fund C2F for Postdoctoral Fellowship, Chulalongkorn University.

Age-Related Inflammation and Degeneration Research Unit, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, , Thailand.

James M. Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, , Thailand. Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, , Thailand.

Siriraj Research Group in Immunobiology and Therapeutic Sciences, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. You can also search for this author in PubMed Google Scholar. T, and P. T, conceived the idea for the manuscript, J.

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Reprints and permissions. The effectiveness of Bacopa monnieri Linn. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data. Sci Rep 11 , Download citation. Received : 26 March Accepted : 14 December Published : 12 January Anyone you share the following link with will be able to read this content:.

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nature scientific reports articles article. Download PDF. Subjects Clinical pharmacology Dementia Diseases Drug discovery Health care Medical research Molecular medicine Neurodegeneration Neurodegenerative diseases Neuroscience Paediatric research Pharmacology.

Abstract Bacopa monnieri Linn. Introduction Neurological disorders include a wide array of problems including neuronal deterioration, cognitive decline, depression, anxiety and have been considered as one of the greatest risks to human health 1.

Bacopa monnieri and its active compounds Bacopa monnieri , a plant belonging to the family Scrophulariaceae, commonly known as Brahmi, occurs naturally throughout south and Southeast Asia. Figure 1. Structures of bacoside compounds that can be isolated from B.

Full size image. Methods Literature selection Over the past 15 years there has been a lot of interest in B. Figure 2. Figure 3. Results Quality of included literature and qualitative analysis Eleven studies 4 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 were selected for inclusion in the meta-analysis, and all scored highly on the study quality scoring system.

Table 1 Neuropsychological tests that were found to have a statistically significant improvement in the B. monnieri treated patients compared to the placebo. Full size table. Quantitative analysis The effect of B. monnieri on memory and attention in healthy patients Across the 11 studies included for the meta-analysis, individuals completed the studies, taking B.

Table 2 Meta-analysis for the effect of B. monnieri on memory and attention in healthy people. Discussion and conclusions Each of the clinical studies in healthy people measured an array of different neuropsychological tests; however, no two studies found statistically significant changes across the same neuropsychological tests.

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ONotropic PHLa dihydrochalcone Neuroprrotection usually present in the Nootropc and leaves of apple tree. Fkr vitro study on Nootropic for Neuroprotection immortalized hypothalamic neurons Nootropic for Neuroprotection to amyloid betademonstrated Nootgopic PHL Nourish your soul influenced membrane fluidity and potential. PHL also significantly decreased excitotoxicity by restoring the calcium homeostasis in the same. Thus, PHL proves to be a promising therapeutic moiety which should be further screened in the treatment of Alzheimer's disease. The objective of the present study was to evaluate the nootropic, neuroprotective and neurotrophic roles of PHL in the subacute scopolamine induced amnesia in mice. In this study, mice were pretreated with PHL 2. p for 14days. There was a significant increase in Blood sugar tips Nuroprotection and duration of the recorded calcium signals, Preventing heart disease through cholesterol control well Neuroprotedtion a Nootropic for Neuroprotection Nootropif in the percentage of active neurons. To assess the modulating Nootroplc of Noopept on Noortopic transmission, we studied Blood sugar tips changes in calcium ion Blood sugar tips during activation of the α7 nicotinic acetylcholine receptor α7 nAChR. There were no significant changes in the amplitude of responses to choline in the presence of Noopept. In electrophysiological experiments patch clamp methodlocal application of choline caused current generation in the stratum radiatum but not pyramidale neurons, the amplitude of which was also not affected by Noopept. Therefore, the data obtained by optical recording confirm the modulating effect of Noopept on hippocampal neuron activity, which is manifested as the increased amplitude and duration of calcium transients in neurons of different layers. This is a preview of subscription content, log in via an institution to check access.