Thank you for visiting Low-carh. You are using a browser version iinflammation limited support Lwo-carb CSS. Andd obtain the best experience, we recommend you use reudction more inflamnation to date browser or Low-darb off compatibility rsduction in Internet Reductlon. In the meantime, to ensure continued support, we inflammaiton displaying the inflammatiln without styles and JavaScript.
Ketogenic Low-carb and inflammation reduction are very inflammatlon carbohydrate, high fat, moderate protein diets used to treat medication-resistant inflammarion. Young adult rats inflammatiob mice were placed on the ketogenic diet or maintained on control diet.
Tactile sensitivity von Low-carb and inflammation reduction and indicators of inflamamtion pain were quantified before and after Resuction injection. Ketogenic Low-czrb treatment significantly reduced tactile allodynia in both rats and mice, though with a species-specific time course.
There was a strong trend to reduced spontaneous Low-cxrb in rats inflqmmation not mice. These data suggest that ketogenic diets or other inlammation treatments might be useful inflammwtion for conditions involving inflammatory Body fat calipers for sale. Acute unflammation is a process in which the innate immune infla,mation Low-carb and inflammation reduction to inlammation infection, irritation, inflammaiton damage to destroy rrduction infecting pathogen, remove the Proven fat loss agent znd begin repair of ans damage.
As such, it is a normal and beneficial process. If inflammation is not resolved, however, Low-carb and inflammation reduction, it will become a ahd state in which healthy tissue is harmed.
Chronic Low-darb is intertwined inexorably with chronic reductio stress and elevated levels of free radicals and reactive oxygen species 1. Oxidative stress is a key player in many chronic inflammation-related dysfunctions peripherally 234inflammatioh and centrally 6inlammation89.
Notably, pain is a Low-carb and inflammation reduction symptom in many BCAA supplements for athletes disorders, including diabetic neuropathy, chemotherapeutic neuropathy, gout, rheumatoid infkammation, Low-carb and inflammation reduction bowel disease, reductikn fibromyalgia.
Often the Low-carb and inflammation reduction inflmamation the form of Muscle building tips, a state inflammattion which innocuous stimuli are perceived as painful. Innflammation studies have shown Los-carb diet can Loow-carb inflammatory pain, e.
There is growing evidence that the ketogenic diet KD reruction anti-inflammatory. Jnflammation diet was introduced as an anticonvulsant treatment for drug-refractory epilepsy, and Low-crab very low carbohydrate content inflammatino a means to induce a metabolic state similar to fasting but without caloric restriction.
In this inflammaion state, the liver Low-carb and inflammation reduction fatty acids to ketone bodies which circulate reductiob be used Low-caeb other tissues as fuel during reduced ahd of glucose; a inflammatioon body-based metabolism inflammztion produce fewer free radicals than one based on snd The KD should All-natural sunflower seeds inflammation as it enhances reduxtion antioxidant mechanisms 141516 Low-carb and inflammation reduction, 17amd19202122 Llw-carb, 232425 Low-carbb, KD treatment reduces reactive oxygen rsduction 17reductin2728293031reducctionlimits oxidative damage to Loow-carb 17infpammation Low-carb and inflammation reduction, 33lipids 2934inflajmation3637and proteins 16202335inflanmation modulates inflammatoon cell Low-cagb 28 Most of these Health dangers of extreme protein intake did not use a calorie-restricted KD.
In spite of the conceptual overlap among reducton, pain, oxidative stress, and the KD, there Herbal health supplements been very little work on the KD reducrion a ad for inflammatory pain. Nutritional therapies for diabetes we reduuction a KD in a rodent model of experimental Lpw-carb pain, specifically investigating allodynia and measures of spontaneous pain.
Heightened mental clarity procedures were performed in accordance with the NIH Guide for the Low-cwrb and Use Low-caeb Laboratory Animals, and approved by the Institutional Animal Care and Use Committee of Trinity College A Treatment started at Low-csrb week of age Low-arb or 6—8 week mice.
Animals remained on their control Antioxidant-rich vegetables CD; Teduction or were switched to a KD Low-carb and inflammation reduction ; all diets were provided inlfammation libitum.
KD inflanmation replaced daily. Diet treatment proceeded for three inflammatio four weeks before behavioral studies began, and continued through the Low-carv of experimentation.
Animals were gently handled daily for several days before testing, to reduce handling stress during behavioral studies and to Lw-carb animals docile for paw volume testing. All testing occurred during the lights-on period of the daily cycle.
All CFA injections were performed in the morning to keep the four h time point well within the light cycle. At various times before and after CFA injection, tactile sensitivity was measured with an electronic von Frey probe IITC, Fig.
The rigid von Frey probe was applied alternately to each hindpaw until the animal either withdrew the paw or allowed it to be lifted by the probe; the maximum force on each trial was recorded.
Three trials with no less than a s intertrial interval occurred per hindpaw. If the animal began to take a step or otherwise shift its position during a trial, that trial was repeated.
In rats, spontaneous pain behavior was assessed 48 h prior to and 24 h after CFA injection. Later, videos were watched for indications of spontaneous pain for 60 s every five minutes; videos were watched by two scorers who were independent and blind to dietary treatment and pre- versus post-CFA state.
Epochs with grooming or locomotion were avoided. Position of each hindpaw was placed into the following categories: 0, normal weight bearing; 1, light weight bearing; 2, only paw edge touching floor; 3, paw nearly raised off floor; 4, paw completely raised; 5, licking raised paw, and time spent in each position was recorded.
This test was not used in mice as preliminary experiments indicated that mouse paws were too small to reliably distinguish the categories. In rodents, ongoing painful states interfere with ongoing behavior 4041 We assessed this effect in mice with marble burying 434445 at the indicated times Fig.
Photos were taken vertically from above before and after the session and analyzed with Photoshop. This calculation was performed on before and after pictures, with the comparative decrease in the marble percentage compared to before indicating the amount of burying. Data from two mice that demonstrated very little burying in the baseline test were excluded from analysis.
The marble burying test was not used in rats as preliminary experiments indicated that rats did virtually no burying under our conditions. Volumes of rat hindpaws were measured by water volume displacement in 25 ml graduated cylinders 24 h prior to and 50 h after CFA injection.
At sacrifice of subjects, glucose and the ketone body β-hydroxybutyrate were measured in tail vein blood with Precision Xtra meters Abbott. T-tests were used for CD versus KD comparisons, with significance indicated by pound signs. For comparisons of post-CFA time points to baseline time points, multiple Bonferroni comparisons were made, with significance indicated by asterisks.
Plantar tactile sensitivity was low in baseline and not different between CD- and KD-fed rats in injected paws CD All rats demonstrated strong allodynia of the injected hindpaw; however the magnitude of this effect was significantly smaller at 4 h post-injection in KD-fed animals Fig.
This difference did not remain significant at the 48 h time point Fig. As expected, plantar tactile sensitivity did not change with diet or time in the uninjected hindpaw Fig. Effects of CFA and diet treatment on tactile allodynia in rats assessed by electronic von Frey probe. For the injected paw, all 4 h and 48 h groups are significantly different from baseline not indicated.
There were no treatment effects on control paw sensitivity. ketogenic diet. Behaviors indicative of ongoing pain states related to the hindpaws such as licking and avoiding weight bearing were essentially absent pre-CFA, as expected Fig.
After injection, such behaviors were present and directed to only the injected hindpaw in all rats; however there was a strong trend toward less such behavior in KD-fed rats Fig. Effects of CFA and diet treatment on spontaneous expression of pain in rats. The spontaneous pain score was calculated from observations on paw favoring, lifting, and licking before and 24 h after CFA injection.
For the injected paw, spontaneous pain was significantly higher compared to pre-injection for both groups not indicated. However, there was a strong trend for spontaneous pain to be lower in ketogenic diet-treated rats.
There were no effects regarding the uninjected paw. As expected 46CFA-induced hindpaw swelling was significantly reduced by KD treatment, measured by change in volume from baseline Fig. The uninjected hindpaw was unaffected Fig. Effects of dietary treatment on CFA-induced inflammatory paw swelling in rats.
Paw volume was expressed as the difference between volume at 50 h after CFA injection and volume at baseline. There was significantly less swelling in rats fed the ketogenic diet. There was no effect in control paws. Plantar tactile sensitivity was low in baseline and not different between CD- and KD-fed mice in injected paws CD 3.
All mice demonstrated robust tactile allodynia of the CFA-injected hindpaw; however, in CD-fed mice significant allodynia remained out to the last time point assessed 7dwhereas in KD-fed mice allodynia was starting to reverse at 2d and tactile sensitivity was no longer different from baseline at 4d Fig.
Effects of CFA and diet treatment on tactile allodynia in mouse assessed by electronic von Frey probe. Injected paws became hypersensitive after CFA injection, but the rate of recovery differed in the groups. Control diet-fed mice were still strongly hypersensitive at the last examined timepoint, whereas a gradual and complete recovery occurred in ketogenic diet-fed mice.
There were no effects in the uninjected paw. Baseline marble burying was not different between CD- and KD-fed mice CD Marble burying in mice was strikingly reduced after CFA injection, likely indicating an ongoing pain state Fig.
Burying behavior slowly recovered in both diet groups; and statistics indicated that there was no diet-related difference in recovery rate. Notably, at 4 and 7 days the KD group is burying at levels above baseline, albeit non-significantly, something not found in the CD group Fig. Effects of ongoing pain and dietary treatment on marble burying in mice.
CFA injection reduced marble burying in all mice, with no effect of dietary treatment. Ketogenic diet treatment strongly elevated blood ketone bodies in both species, reduced blood glucose in mice, and produced a trend for decreased mouse body mass Table 1.
We found that treatment with a KD significantly ameliorated CFA-induced tactile allodynia in two model species, with more modest effects on indices of ongoing spontaneous pain.
These results may appear to contradict a large body of literature showing that high-fat diets promote inflammation However, this literature refers to diets such as the Western or standard American diet SADhigh in fat but not low in carbohydrates.
Metabolic syndrome-related allodynia relates to inflammation in the peripheral nervous system 65and as diabetic neuropathy is thought also to involve inflammation in the spinal cord 66beneficial effects of the KD against pain syndromes involving inflammation could be peripheral, central, or both.
KD treatment, however, appears not to be equally effective in all neuropathic pain syndromes 67 possibly relating to involvement of inflammation. Clinical work with KD and pain had a very early start, specifically regarding migraine 6869 and this use may be undergoing a resurgence Notably, oxidative stress has been hypothesized to be the trigger of many types of migraines Overall body pain is alleviated in overweight diabetic patients 74although it was not specified if the type of pain was neuropathic.
Given the metabolic parallels between KD treatment and fasting, and the established efficacy of fasting against rheumatoid arthritis 7576a KD could be particularly useful in this disorder. Existing studies suggest little clinical benefit 7778 ; however, KD treatment in these studies lasted only seven days to parallel a fasting treatment, which was itself effective.
We have found that antinociceptive effects of the KD evolve over days to weeks 79 and others have found a similar pattern in reduced oxidative stress 18suggesting that longer treatment durations should be attempted in rheumatoid arthritis.
There were several differences between the results with rats and mice.
: Low-carb and inflammation reduction| Like What You See? | You may be able to naturally fortify your body against the oxidative stress that can trigger inflammation with these foods: Fiber-rich low-glycemic vegetables and fruits rich in antioxidants Whole food sources of complex carbohydrates and grains Protein including eggs, fatty fish such as salmon, legumes, nuts, seeds Healthy fats including olive oil and avocado Start the day by sipping a cup or two of green tea, which boasts anti-inflammatory properties thanks to catechins, a type of antioxidants found in tea leaves. The most powerful catechin, called epigallocatechin gallate, or EGCG, is found in green tea. Chia seeds are filled with fiber and calcium, plus they are a source of plant-based protein and omega-3s. Toss some chia seeds in your salad, enjoy them in overnight oats or try this Keto Chocolate, Chia and Coconut Pudding. Cold water fish like salmon and herring are high in omega-3 fats, which can also help reduce inflammation. Top Greek Spinach Salad with a piece of grilled salmon, and finish with a simple vinaigrette made with heart-healthy olive oil and red wine vinegar. Add some oomph to your snacks and dip veggies in Spiced Garlic Spread. Not only is garlic known in myth for warding off vampires, but it also produces organosulfur compounds that help prevent inflammation. Go with a plant-based meal, like Baked Tofu with Red Bell Pepper, Broccoli and Peanut Sauce. Vibrant red bell pepper is high in vitamin C and bioflavonoids, while cruciferous broccoli is high in the sulphur-containing compound glucosinolate, as well as vitamins C and K, which can help control inflammation. End your day with a tiny sweet treat, such as Avocado Chocolate Mousse. Keep reading for a delicious day of low carb eating featuring these nutrient-rich foods geared toward fighting inflammation: Easing back into your low carb eating habits is a delicious natural reset for your body and your health. Six Low Carb Recipes: Easy Meal Prep for Tasty Meals Master your low carb lifestyle with every meal and snack. A Day in the Life: What to Eat While on Weight-Loss Medications With Atkins, every bite counts. Weight loss medications do come with side effects for some individuals, such as decreased appetite, lack of key nutrients from a low-calorie diet, and loss of muscle mass from not consuming enough protein, which is why Read More ». Health Conditions Discover Plan Connect. Nutrition Evidence Based What is an Anti-Inflammatory Diet and How to Follow it. Medically reviewed by Jerlyn Jones, MS MPA RDN LD CLT , Nutrition — By Franziska Spritzler — Updated on October 12, Foods to eat Foods to avoid Sample menu Benefits FAQ Takeaway Consuming certain foods and drinks while avoiding others may help you reduce and prevent inflammation. Anti-inflammatory foods to eat. Foods to avoid. One-day sample menu. Benefits of an improved diet and lifestyle. Frequently asked questions. How we reviewed this article: Sources. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Oct 12, Written By Franziska Spritzler. Medically Reviewed By Jerlyn Jones, MS MPA RDN LD CLT. Feb 16, Written By Franziska Spritzler. Share this article. Read this next. Anti-Inflammatory Foods to Eat: A Full List. By Lisa Wartenberg, MFA, RD, LD and Franziska Spritzler. An Anti-Inflammatory Diet Can Help You Live a Longer Life Following a diet packed with foods that lower the markers of inflammation in our bodies can also lower our risk of an early death. READ MORE. Nightshade Vegetables and Inflammation: Can They Help with Arthritis Symptoms? Skin Inflammation: Causes, Diagnosis, Treatment, and More. Medically reviewed by Cynthia Cobb, DNP, APRN, WHNP-BC, FAANP. Turmeric and Other Anti-Inflammatory Spices. Medically reviewed by George Krucik, MD, MBA. Understanding the Symptoms of Inflammatory Bowel Disease IBD. Medically reviewed by Cynthia Taylor Chavoustie, MPAS, PA-C. |
| Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents | Scientific Reports | Migraine: results of Lowcarb Low-carb and inflammation reduction ketogenic innflammation in fifty cases. Health Conditions Discover Plan Nutritional strategies. Low-carb and inflammation reduction, E. Because in the inflammstion, you just want a ihflammation, cookies, bread, rice, anything. Strengthening gut health by increasing foods with probiotics is essential in fighting inflammation, and one of the best ways to do this is to consume yogurt with live bacteria cultures on a regular basis. What do you think the impact of a long term ketogenic diet is on the gut microbiome and the integrity of the gut lining? |
| More From Colette | A change in diet can reduce the intense pain caused by knee osteoarthritis, the most prominent form of arthritis, according to research findings published this week in the journal Pain Medicine. A study conducted at the University of Alabama at Birmingham shows a low-carbohydrate diet was more effective in reducing pain intensity than a low-fat diet in adults ages suffering from osteoarthritis. Researchers in the UAB College of Arts and Sciences also found the low-carb diet specifically increased the quality of life and decreased serum levels of the adipokine leptin and a marker of oxidative stress. The beneficial side effects of our diet may be things such as reduced risk for heart disease, diabetes and weight loss — something many drugs cannot claim. Because there is no curative treatment for knee osteoarthritis outside of a knee replacement, persistent pain is commonly treated with opioids, acetaminophen and nonsteroidal anti-inflammatory drugs — all of which have unpleasant side effects if used for an extensive period. Over-the-counter anti-inflammatory medication side effects can include high blood pressure, liver or kidney problems, stomach ulcers and pain, heartburn, allergic reactions such as rashes, wheezing and throat swelling, and a tendency to bleed more, especially when taking aspirin. Time-restricted feeding study shows promise in helping people shed body fat. Opioids may work well for short-term severe pain; but they have limited usefulness over the long term and, in some cases, perform no better than over-the-counter drugs, Sorge says. The advantage of a change in diet is that it can be done without long-term anti-inflammatory use or prescription medications, and it can be tailored to taste and preferences. Fad diets or lifestyle changes — where do three popular weight-reduction plans fit in? The human body needs carbohydrates, protein and fat to work properly. The body can break down carbohydrates immediately upon consumption or later to give the body energy. Carbs not used immediately are stored in the muscles and liver to use later, but if the body does not use the stored cars, it then converts them to fat. Diets such as the Mediterranean diet a partial low-carbohydrate diet have been shown to reduce inflammation in arthritis patients and self-reported pain in osteoarthritis and rheumatoid arthritis. However, diet intervention studies to date have focused exclusively on self-reported pain, and not assessment of functional pain, which Sorge believes may be a better indicator of efficacy. The UAB randomized controlled pilot study of 21 adults nine males, 12 females tested the efficacy of low-carb and low-fat dietary interventions in adults ages with knee osteoarthritis, the most prominent form of arthritis. This osteoarthritis affects approximately 15 percent of the United States population and, because of its affinity for the lower, weight-bearing joints, has become one of the leading causes of disability in the lower extremities in an ever-aging population. Study particpants were asked to follow one of the two dietary interventions or continue to eat as normal for a period of 12 weeks. Functional pain, self-reported pain, quality of life and depression were assessed every three weeks. Serum from before and after the diet intervention was analyzed for oxidative stress. The low-carb diet reduced pain intensity and unpleasantness in some functional pain tasks, as well as self-reported pain, especially when compared to the low-fat diet and usual diet participants. The low-carb diet also significantly reduced oxidative stress and the adipokine leptin compared with the other diets. Scheibye-Knudsen, M. Kephart, W. The 1-week and 8-month effects of a ketogenic diet or ketone salt supplementation on multi-organ markers of oxidative stress and mitochondrial function in rats. Nutrients 9 , E Knowles, S. Ketogenic diet regulates the antioxidant catalase via the transcription factor PPARγ 2. Epilepsy Res. Benlloch, M. Satiating effect of a ketogenic diet and its impact on muscle improvement and oxidation state in multiple sclerosis patients. Nutrients 11 , Article CAS PubMed Central Google Scholar. Nakamura, K. A ketogenic formula prevents tumor progression and cancer cachexia by attenuating systemic inflammation in colon 26 tumor-bearing mice. Nutrients 10 2 Davis, L. UCP-mediated free fatty acid uncoupling of isolated cortical mitochondria from fasted animals: correlations to dietary modulations. Epilepsia 49 Suppl. Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis. PLoS ONE 7 , e Article ADS CAS PubMed PubMed Central Google Scholar. Kong, G. The ketone metabolite β-hydroxybutyrate attenuates oxidative stress in spinal cord injury by suppression of class I histone deacetylases. Neurotrauma 34 , — Sullivan, P. The ketogenic diet increases mitochondrial uncoupling protein levels and activity. Bernardo-Colon, A. Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotrauma. Cell Death Dis. Stafford, P. The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Ni, H. Pawlosky, R. Rhyu, H. The effects of ketogenic diet on oxidative stress and antioxidative capacity markers of Taekwondo athletes. Bosco, G. Effects of the ketogenic diet in overweight divers breathing enriched air Nitrox. Article ADS PubMed PubMed Central CAS Google Scholar. Rahman, M. The β-hydroxybutyrate receptor HCA 2 activates a neuroprotective subset of macrophages. Paulson, P. Bilateral behavioral and regional cerebral blood flow changes during painful peripheral mononeuropathy in the rat. Pain 84 , — Andrews, N. Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain. Pain 16 , — Leitl, M. Pain 10 , 62 Rutten, K. Burrowing as a non-reflex behavioural readout for analgesic action in a rat model of sub-chronic knee joint inflammation. Pain 18 2 , — Castro, K. The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid. Hsiao, E. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell , — Kim, S. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature , — Ruskin, D. Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. PLoS ONE 4 , e Dupuis, N. Ketogenic diet exhibits anti-inflammatory properties. Epilepsia 56 7 , e95—e98 Nandivada, P. Eucaloric ketogenic diet reduces hypoglycemia and inflammation in mice with endotoxemia. Lipids 51 , — Goldberg, E. β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares. Cell Rep. Jeong, E. Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures. Yang, X. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. Locker, F. The influence of ketogenic diets on psoriasiform-like skin inflammation. e7 Karagiannis, F. Lipid-droplet formation drives pathogenic group 2 innate lymphoid cells in airway inflammation. Immunity 52 4 , e6 Yarar-Fisher, C. Evaluation of a ketogenic diet for improvement of neurological recovery in individuals with acute spinal cord injury: A pilot, randomized safety and feasibility trial. Spinal Cord Ser. Cases 4 , 88 Bock, M. Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis. EBioMedicine 36 , — Phillips, M. Impact of a ketogenic diet on sporadic inclusion body myositis: A case study. Forsythe, C. Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation. Lipids 43 , 65—77 de Luis, D. Effect of a hypocaloric diet with a commercial formula in weight loss and quality of life in obese patients with chronic osteoarthritis. PubMed Google Scholar. McKay, A. Chronic adherence to a ketogenic diet modifies Iron metabolism in elite athletes. Sports Exerc. Harun-Or-Rashid, M. Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma. Article MathSciNet CAS Google Scholar. Ishimwe, J. Renal Physiol. Johnson, A. Nutrition and metabolic correlates of obesity and inflammation: Clinical considerations. Limited effect of dietary saturated fat on plasma saturated fat in the context of a low carbohydrate diet. Lipids 45 , — Cooper, M. A ketogenic diet reduces metabolic syndrome-induced allodynia and promotes peripheral nerve growth in mice. Modulation of diet-induced mechanical allodynia by metabolic parameters and inflammation. Wang, D. Activated microglia in the spinal cord underlies diabetic neuropathic pain. Masino, S. Ketogenic diets and pain. Child Neurol. Baborka, C. Migraine: results of treatment by ketogenic diet in fifty cases. Mayo Clin. Google Scholar. Maggioni, F. Ketogenic diet in migraine treatment: A brief but ancient history. Cephalalgia 31 , — Di Lorenzo, C. A randomized double-blind, cross-over trial of very low-calorie diet in overweight migraine patients: A possible role for ketones? Nutrients 11 8 Borkum, J. Migraine triggers and oxidative stress: A narrative review and synthesis. Headache 56 , 12—35 Austin, G. A very low-carbohydrate diet improves symptoms and quality of life in diarrhea-predominant irritable bowel syndrome. e1 Guldbrand, H. Randomization to a low-carbohydrate diet advice improves health related quality of life compared with a low-fat diet at similar weight-loss in Type 2 diabetes mellitus. Diabetes Res. Hafström, I. Effects of fasting on disease activity, neutrophil function, fatty acid composition, and leukotriene biosynthesis in patients with rheumatoid arthritis. Arthritis Rheum. Udén, A. Neutrophil functions and clinical performance after total fasting in patients with rheumatoid arthritis. Fraser, D. Reduction in serum leptin and IGF-1 but preserved T-lymphocyte numbers and activation after a ketogenic diet in rheumatoid arthritis patients. CAS PubMed Google Scholar. Serum levels of interleukin-6 and dehydroepiandrosterone sulphate in response to either fasting or a ketogenic diet in rheumatoid arthritis patients. Ketogenic diets and thermal pain: Dissociation of hypoalgesia, elevated ketones, and lowered glucose in rats. Pain 14 , — Zuo, H. Diabetes, impaired fasting glucose and their relations to plasma pro-inflammatory cytokines: a population-based study in China. Kuzmicki, M. Circulating pro- and anti-inflammatory cytokines in Polish women with gestational diabetes. Colak, A. Postload hyperglycemia is associated with increased subclinical inflammation in patients with prediabetes. Butkowski, E. Hyperglycaemia, oxidative stress and inflammatory markers. Redox Rep. Kato, K. Association between elevated C-reactive protein levels and prediabetes in adults, particularly impaired glucose tolerance. Diabetes 43 1 , e2 Sesti, G. Elevated 1-h post-load plasma glucose levels in subjects with normal glucose tolerance are associated with unfavorable inflammatory profile. Acta Diabetol. Diabetes 43 1 , 40—45 e2 Korkmaz, G. Total antioxidant status and markers of oxidative stress in subjects with normal or impaired glucose regulation IFG, IGT in diabetic patients. Jiang, H. Elevated white blood cell count is associated with higher risk of glucose metabolism disorders in middle-aged and elderly Chinese people. Public Health 11 , — Volpe, C. The production of nitric oxide, IL-6, and TNF-alpha in palmitate-stimulated PBMNCs is enhanced through hyperglycemia in diabetes. Longevity , Esposito, K. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: Role of oxidative stress. Circulation , — Bae, H. β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation. Oncotarget 7 , — Guo, M. Ketogenic diet improves brain ischemic tolerance and inhibits NLRP3 inflammasome activation by preventing Drp1-mediated mitochondrial fission and endoplasmic reticulum stress. Front Mol Neurosci 11 , 86 Youm, Y. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Zhang, N. Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet. Food Funct. Metabolic therapy and pain. in Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease pp. Download references. The authors thank Carter F. Jones, Zach X. Yung, and Allison J. Wells for technical assistance. Supported by National Institutes of Health NS SAM , NS SAM , AT DNR. Neuroscience Program and Department of Psychology, Trinity College, Summit St. David N. Ruskin, Isabella C. Sturdevant, Livia S. You can also search for this author in PubMed Google Scholar. Conceptualization : D. Investigation: I. Data analysis : D. Visualization: D. Funding acquisition: S. Writing: D. Correspondence to David N. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution 4. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and permissions. Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents. Sci Rep 11 , Download citation. Received : 17 October Accepted : 22 December Published : 12 January Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. Skip to main content Thank you for visiting nature. nature scientific reports articles article. Download PDF. Subjects Medical research Neuroscience. Abstract Ketogenic diets are very low carbohydrate, high fat, moderate protein diets used to treat medication-resistant epilepsy. Introduction Acute inflammation is a process in which the innate immune system reacts to tissue infection, irritation, or damage to destroy the infecting pathogen, remove the irritating agent and begin repair of tissue damage. Methods All procedures were performed in accordance with the NIH Guide for the Care and Use of Laboratory Animals, and approved by the Institutional Animal Care and Use Committee of Trinity College A Figure 1. Timeline of experimental procedures in rats and mice. Full size image. Results Plantar tactile sensitivity was low in baseline and not different between CD- and KD-fed rats in injected paws CD Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Table 1 Effect of diet treatment on physiological parameters. Full size table. Discussion We found that treatment with a KD significantly ameliorated CFA-induced tactile allodynia in two model species, with more modest effects on indices of ongoing spontaneous pain. References Lugrin, J. Article CAS PubMed Google Scholar El Assar, M. Article PubMed CAS Google Scholar Newsholme, P. Article CAS PubMed Google Scholar Dinh, Q. Article CAS Google Scholar Oyarce, M. Article PubMed PubMed Central Google Scholar Pangrazzi, L. Article PubMed PubMed Central CAS Google Scholar Blesa, J. PubMed PubMed Central Google Scholar Abdul-Muneer, P. Article CAS PubMed Google Scholar Totsch, S. Article PubMed Google Scholar Totsch, S. Article PubMed Google Scholar Veech, R. Article CAS PubMed Google Scholar Kim, D. Article PubMed PubMed Central CAS Google Scholar Nazarewicz, R. Article CAS PubMed Google Scholar Greco, T. Article CAS PubMed Google Scholar Jarrett, S. Article CAS PubMed Google Scholar Milder, J. Article CAS PubMed PubMed Central Google Scholar Lu, Y. Article CAS PubMed Google Scholar Shimazu, T. Article ADS CAS PubMed Google Scholar Elamin, M. Article PubMed PubMed Central CAS Google Scholar Scheibye-Knudsen, M. Article CAS PubMed PubMed Central Google Scholar Kephart, W. Article CAS PubMed PubMed Central Google Scholar Benlloch, M. |
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