Nutr Res Rev Anrioxidant 21 AAntioxidant : Anioxidant The first meta-analysis Blueberry pastry recipes want Blueberry pastry recipes fkr comes fromand is comprised ofsubjects, which is Low-carb and mental clarity lot of participants. Increased serum and low-density-lipoprotein antioxidant potential after antioxidant supplementation in endurance athletes. Add the lemon juice and remove from the heat. J Appl Physiol ; 98 1 : 3—30 Article PubMed Google Scholar Herrera E, Jiménez R, Aruoma OI, et al. So antioxidant supplementation appears to be at best neutral, and quite possibly negative in regards to health.

Antioxidant supplements for athletes -

Journal Article. Antioxidant Requirements of Endurance Athletes: Implications for Health. Williams, BSc Hons , Sarah L. Williams, BSc Hons. Exercise and Oxidative Stress Research Group, School of Human Movement Studies, University of Queensland, St.

Lucia, Queensland, Australia, Oxford Academic. Google Scholar. Natalie A. Strobel, Postgrad Dip Clin Ex Sci. Louise A. Lexis, PhD. School of Biomedical Sciences, Victoria University, Melbourne, Victoria, Australia.

Jeff S. Coombes, PhD. School of Human Movement Studies, Room , Connell Building, University of Queensland, St. Lucia, Queensland, Australia ; Phone: 61—7——; Fax: 61—7——; E-mail: jcoombes hms.

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Abstract This review discusses studies investigating the effects of antioxidant supplementation on exercise-induced oxidative stress with a focus on the health implications. exercise , dietary supplements , oxidative damage , reactive oxygen species. Issue Section:. Download all slides.

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Pharmacol Rev Mar 1; 58 1 : 87— Sies H. Strategies of antioxidant defense. Eur J Biochem ; 2 : —9. Oxidative stress: from basic research to clinical application. Am J Med ; 91 3C : S31—8.

Jones DP. Redefining oxidative stress. Antioxid Redox Signal ; 8 : — Sharman JE, Cockcroft JR, Coombes JS. Cardiovascular implications of exposure to traffic air pollution during exercise. QJM ; 97 10 : — Sorg O. Oxidative stress: a theoretical model or a biological reality?

C R Biol ; 7 : — Roberts CK, Barnard RJ. Effects of exercise and diet on chronic disease. J Appl Physiol ; 98 1 : 3— Herrera E, Jiménez R, Aruoma OI, et al.

Aspects of antioxidant foods and supplements in health and disease. Nutr Rev ; S—4. Alessio HM, Goldfarb AH, Cao G.

Exercise-induced oxidative stress before and after vitamin C supplementation. Int J Sport Nutr ; 7 1 : 1—9. Goldfarb AH, Bloomer RJ, McKenzie MJ. Combined antioxidant treatment effects on blood oxidative stress after eccentric exercise.

Med Sci Sports Exerc ; 37 2 : —9. Meydani M, Evans WJ, Handelman G, et al. Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults. Am J Physiol Regul Integr Comp Physiol ; 5 : R—8.

Vina J, Gomez-Cabrera MC, Borras C. Fostering antioxidant defences: up-regulation of antioxidant genes or antioxidant supplementation?

Br J Nutr ; 98 Suppl. Lykkesfeldt J, Poulsen HE. Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials. Br J Nutr ; 09 : —9.

Kritchevsky SB, Shimakawa T, Tell GS, et al. Dietary antioxidants and carotid artery wall thickness. The ARIC Study Atherosclerosis Risk in Communities Study Circulation ; 92 8 : — Gaziano JM, Manson JE, Branch LG, et al.

A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly.

Ann Epidemiol ; 5 4 : — Gey KF, Brubacher GB, Stahelin HB. Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. Am J Clin Nutr ; 45 5 Suppl. Schunemann HJ, Grant BJ, Freudenheim JL, et al. The relation of serum levels of antioxidant vitamins C and E, retinol and carotenoids with pulmonary function in the general population.

Am J Respir Crit Care Med ; 5 : — Combs Jr GF, Clark LC, Turnbull BW. Reduction of cancer mortality and incidence by selenium supplementation. Med Klin Munich ; 92 Suppl.

Lonn E, Bosch J, Yusuf S, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA ; 11 : — Sesso HD, Buring JE, Christen WG, et al.

JAMA ; 18 : — Lee IM, Cook NR, Manson JE, et al. J Natl Cancer Inst ; 91 24 : —6. Heart Protection Study Collaborative Group. Lancet ; : 23— Albanes D, Heinonen OP, Taylor PR, et al. Alphatocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance.

J Natl Cancer Inst ; 88 21 : — Goodman GE, Thornquist MD, Balmes J, et al. The betacarotene and retinol efficacy trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow- up after stopping beta-carotene and retinol supplements.

J Natl Cancer Inst ; 96 23 : — Bjelakovic G, Nikolova D, Gluud LL, et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and metaanalysis. JAMA ; 8 : — Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling.

Am J Physiol Lung Cell Mol Physiol ; 6 : L— Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol ; 39 1 : 44— Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med ; 28 3 : — Li T-S, Marbán E.

Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells. Stem Cells ; 28 7 : — Panasyuk A, Frati E, Ribault D, et al. Effect of reactive oxygen species on the biosynthesis and structure of newly synthesized proteoglycans.

Free Radic Biol Med ; 16 2 : — Wagner AH, Kohler T, Ruckschloss U, et al. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation.

Arterioscler Thromb Vasc Biol ; 20 1 : 61—9. Jackson MJ. Free radicals generated by contracting muscle: by-products of metabolism or key regulators of muscle function? Free Radic Biol Med ; 44 2 : — Sen CK. Oxidants and antioxidants in exercise.

J Appl Physiol ; 79 3 : — Brady PS, Brady LJ, Ullrey DE. Selenium, vitamin E and the response to swimming stress in the rat. J Nutr ; 6 : —9. Davies KJ, Quintanilha AT, Brooks GA, et al. Free radicals and tissue damage produced by exercise.

Biochem Biophys Res Commun ; 4 : — Niess AM, Simon P. Response and adaptation of skeletal muscle to exercise: the role of reactive oxygen species. Front Biosci ; — Ji LL. Modulation of skeletal muscle antioxidant defense by exercise: role of redox signaling.

Free Radic Biol Med Jan 15; 44 2 : — Radak Z, Chung HY, Koltai E, et al. Exercise, oxidative stress and hormesis. Ageing Res Rev Jan; 7 1 : 34— Gomez-Cabrera MC, Domenech E, Vina J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Ristow M, Zarse K, Oberbach A, et al.

Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A ; 21 : — Chang CK, Huang HY, Tseng HF, et al. Interaction of vitamin E and exercise training on oxidative stress and antioxidant enzyme activities in rat skeletal muscles.

J Nutr Biochem ; 18 1 : 39— Knez WL, Jenkins DG, Coombes JS. Oxidative stress in half and full Ironman triathletes. Med Sci Sports Exerc Feb; 39 2 : —8. Pikosky MA, Gaine PC, Martin WF, et al.

Aerobic exercise training increases skeletal muscle protein turnover in healthy adults at rest. J Nutr ; 2 : — Radák Z, Apor P, Pucsok J, et al. Marathon running alters the DNA base excision repair in human skeletal muscle.

Life Sciences ; 72 14 : — Okamura K, Doi T, Sakurai M, et al. Effect of endurance exercise on the tissue 8-hydroxy-deoxyguanosine content in dogs.

Free Radic Res ; 26 6 : —8. Gomez-Cabrera MC, Domenech E, Romagnoli M, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr ; 87 1 : —9. Khassaf M, McArdle A, Esanu C, et al.

Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle.

J Physiol ; Pt2 : — Fischer CP, Hiscock NJ, Basu S, et al. Vitamin E isoformspecific inhibition of the exercise-induced heat shock protein 72 expression in humans. J Appl Physiol ; 5 : — Radak Z, Chung HY, Goto S.

Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med ; 44 2 : —9. Powers SK, Duarte J, Kavazis AN, et al. Reactive oxygen species are signalling molecules for skeletal muscle adaptation.

Exp Physiol ; 95 1 : 1—9. Mattson MP. Hormesis defined. Ageing Res Rev ; 7 1 : 1—7. Ristow M, Zarse K. How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis mitohormesis. Exp Gerontol ; 45 6 : —8. Reid MB. J Appl Physiol ; 90 2 : — Reid MB, Khawli FA, Moody MR.

Reactive oxygen in skeletal muscle. III: contractility of unfatigued muscle J Appl Physiol ; 75 3 : —7. Reid MB, Moody MR. Dimethyl sulfoxide depresses skeletal muscle contractility. J Appl Physiol ; 76 5 : — Nitric oxide, reactive oxygen species, and skeletal muscle contraction.

Med Sci Sports Exerc ; 33 3 : —6. Newham DJ, McPhail G, Mills KR, et al. Ultrastructural changes after concentric and eccentric contractions of human muscle. J Neurol Sci ; 61 1 : — Raastad T, Owe SG, Paulsen G, et al.

Changes in calpain activity, muscle structure, and function after eccentric exercise. Med Sci Sports Exerc ; 42 1 : 86— Bailey DM, Williams C, Betts JA, et al. Oxidative stress, inflammation and recovery of muscle function after damaging exercise: effect of 6-week mixed antioxidant supplementation.

Eur J Appl Physiol ; 6 : — Beaton LJ, Allan DA, Tarnopolsky MA, et al. Contraction-induced muscle damage is unaffected by vitamin E supplementation. Med Sci Sports Exerc ; 34 5 : — Van Der Meulen JH, McArdle A, Jackson MJ, et al.

Contraction- induced injury to the extensor digitorum longus muscles of rats: the role of vitamin E. J Appl Physiol ; 83 3 : — Thompson D, Williams C, Kingsley M, et al. Muscle soreness and damage parameters after prolonged intermittent shuttle-running following acute vitamin C supplementation.

Int J Sports Med ; 22 1 : 68— Thompson D, Bailey DM, Hill J, et al. Prolonged vitamin C supplementation and recovery from eccentric exercise. Eur J Appl Physiol ; 92 : —8. Bailey DM, Lawrenson L, Mceneny J, et al.

Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle. Free Radic Res ; 41 2 : — Thompson D, Williams C, McGregor SJ, et al. Prolonged vitamin C supplementation and recovery from demanding exercise.

Int J Sport Nutr Exerc Metab ; 11 4 : — Young IM, Thomson K. Spinning-induced rhabdomyolysis: a case report. Eur J Emerg Med ; 11 6 : —9. Millet GY, Tomazin K, Verges S, et al. Neuromuscular consequences of an extreme mountain ultra-marathon. PLoS One ; 6 2 : e Byrd SK.

Alterations in the sarcoplasmic reticulum: a possible link to exercise-induced muscle damage. Med Sci Sports Exerc ; 24 5 : —6. Thomas AC, McLean SG, Palmieri-Smith RM. Quadriceps and hamstrings fatigue alters hip and knee mechanics. J Appl Biomech ; 26 2 : — Sobal J, Marquart LF.

Int J Sport Nutr ; 4 4 : — Slater G, Tan B, Teh KC. Dietary supplementation practices of Singaporean athletes. Int J Sport Nutr Exerc Metab ; 13 3 : — Braun H, Koehler K, Geyer H, et al. Dietary supplement use among elite young German athletes. Int J Sport Nutr Exerc Metab ; 19 1 : 97— Froiland K, Koszewski W, Hingst J, et al.

Nutritional supplement use among college athletes and their sources of information. Int J Sport Nutr Exerc Metab ; 14 1 : — Krumbach CJ, Ellis DR, Driskell JA. A report of vitamin and mineral supplement use among university athletes in a division I institution.

Int J Sport Nutr ; 9 4 : — Sacheck JM, Milbury PE, Cannon JG, et al. Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men.

Free Radic Biol Med ; 34 12 : — Silva L, Pinho C, Silveira P, et al. Vitamin E supplementation decreases muscular and oxidative damage but not inflammatory response induced by eccentric contraction. J Physiol Sci ; 60 1 : 51—7.

Simon-Schnass I, Pabst H. Influence of vitamin E on physical performance. Int J Vitam Nutr Res ; 58 1 : 49— Satoshi S, Kiyoji T, Hiroyo K, et al. Exercise-induced lipid peroxidation and leakage of enzymes before and after vitamin E supplementation. Int J Biochem ; 21 8 : —8.

Itoh H, Ohkuwa T, Yamazaki Y, et al. Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training. Int J Sports Med ; 21 5 : — Reznick AZ, Witt E, Matsumoto M, et al.

Vitamin E inhibits protein oxidation in skeletal muscle of resting and exercised rats. Biochem Biophys Res Comm ; 2 : —6. Rokitzki L, Logemann E, Huber G, et al. Alphatocopherol supplementation in racing cyclists during extreme endurance training.

Int J Sport Nutr ; 4 3 : — Sanchez-Quesada JL, Jorba O, Payes A, et al. Ascorbic acid inhibits the increase in low-density lipoprotein LDL susceptibility to oxidation and the proportion of electronegative LDL induced by intense aerobic exercise. Coron Artery Dis ; 9 5 : — Tauler P, Aguiló A, Gimeno I, et al.

Influence of vitamin C diet supplementation on endogenous antioxidant defences during exhaustive exercise. Pflügers Arch Eur J Physiol ; 6 : — Vasankari T, Kujala U, Sarna S, et al. Effects of ascorbic acid and carbohydrate ingestion on exercise induced oxidative stress.

J Sports Med Phys Fitness Dec; 38 4 : —5. Ashton T, Young IS, Peters JR, et al. Electron spin resonance spectroscopy, exercise, and oxidative stress: an ascorbic acid intervention study.

J Appl Physiol ; 87 6 : —6. Goldfarb AH, Patrick SW, Bryer S, et al. Int J Sport Nutr Exerc Metab ; 15 3 : — Rosa EF, Ribeiro RF, Pereira FMT, et al. Vitamin C and E supplementation prevents mitochondrial damage of ileum myocytes caused by intense and exhaustive exercise training.

J Appl Physiol ; 5 : —8. Ryan MJ, Dudash HJ, Docherty M, et al. Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats.

Exp Gerontol ; 45 11 : — Schröder H, Navarro E, Mora J, et al. Effects of a-tocopherol, b-carotene and ascorbic acid on oxidative, hormonal and enzymatic exercise stress markers in habitual training activity of professional basketball players.

Eur J Nutr ; 40 4 : — Response of blood cell antioxidant enzyme defences to antioxidant diet supplementation and to intense exercise. Eur J Nutr ; 45 4 : — Kanter MM, Nolte LA, Holloszy JO. Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise.

J Appl Physiol ; 74 2 : —9. Tauler P, Aguiló A, Fuentespina E, et al. Diet supplementation with vitamin E, vitamin C and X-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes. Pflügers Arch European J Physiol ; 5 : —7. Bryant RJ, Ryder J, Martino P, et al. Effects of vitamin E and C supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists.

J Strength Cond Res Nov; 17 4 : — Aguiló A, Tauler P, Fuentespina E, et al. Antioxidant diet supplementation influences blood iron status in endurance athletes. Int J Sport Nutr Exerc Metab ; 14 2 : — Zoppi CC, Hohl R, Silva FC, et al. Vitamin C and e supplementation effects in professional soccer players under regular training.

J Int Soc Sports Nutr ; 3: 37— Fischer CP, Hiscock NJ, Penkowa M, et al. Supplementation with vitamins C and E inhibits the release of interleukin- 6 from contracting human skeletal muscle. Giacomo CD, Acquaviva R, Sorrenti V, et al. Oxidative and antioxidant status in plasma of runners: effect of oral supplementation with natural antioxidants.

J Med Food ; 12 1 : — Jackson JR, Ryan MJ, Hao Y, et al. Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats. Am J Physiol Regul Integr Comp Physiol ; 6 : R— Ryan MJ, Jackson JR, Hao Y, et al.

Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice. J Gerontol Series A Biol Sci Med Sci ; 65 8 : — Chang W-H, Hu S-P, Huang Y-F, et al.

Effect of purple sweet potato leaves consumption on exercise-induced oxidative stress and IL-6 and HSP72 levels. J Appl Physiol ; 6 : —5. Lafay S, Jan C, Nardon K, et al. Grape extract improves antioxidant status and physical performance in elite male athletes.

J Sports Sci Med ; 8 3 : — Pilaczynska-Szczesniak L, Skarpanska-Steinborn A, Deskur E, et al. The influence of chokeberry juice supplementation on the reduction of oxidative stress resulting from an incremental rowing ergometer exercise.

Int J Sport Nutr Exerc Metab ; 15 1 : 48— Nakazato K, Ochi E, Waga T. Dietary apple polyphenols have preventive effects against lengthening contractioninduced muscle injuries.

Mol Nutr Food Res ; 54 3 : — Morillas-Ruiz JM, Villegas García JA, López FJ, et al. Effects of polyphenolic antioxidants on exercise-induced oxidative stress. Clin Nutr ; 25 3 : — Bowtell JL, Sumners DP, Dyer A, et al.

Montmorency cherry juice reduces muscle damage caused by intensive strength exercise. Med Sci Sports Exerc ; 43 8 : — Sumida S, Doi T, Sakurai M, et al. Effect of a single bout of exercise and b-carotene supplementation on the urinary excretion of 8-hydroxy-deoxyguanosine in humans.

Free Radic Res ; 27 6 : — Chae C-H, Shin C-H, Kim H-T. The combination of [alpha]- lipoic acid supplementation and aerobic exercise inhibits lipid peroxidation in rat skeletal muscles. Nutr Res ; 28 6 : — Sen CK, Rankinen T, Vaisanen S, et al. Oxidative stress after human exercise: effect of N-acetylcysteine supplementation.

J Appl Physiol ; 76 6 : —7. Akil M, Gurbuz U, Bicer M, et al. Effect of selenium supplementation on lipid peroxidation, antioxidant enzymes, and lactate levels in rats immediately after acute swimming exercise. Biol Trace Elem Res ; 3 : —9.

Kaikkonen J, Kosonen L, Nyyssönen K, et al. Effect of combined coenzyme Q10 and d-a-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: a placebo-controlled double-blind study in marathon runners. Free Radic Res ; 29 1 : 85— Laaksonen R, Fogelholm M, Himberg J, et al.

Ubiquinone supplementation and exercise capacity in trained young and older men. Eur J Appl Physiol Occup Physiol ; 72 1 : 95— Maxwell SR, Jakeman P, Thomason H, et al. Changes in plasma antioxidant status during eccentric exercise and the effect of vitamin supplementation. Free Radic Res Commun ; 19 3 : — Viitala PE, Newhouse IJ, LaVoie N, et al.

The effects of antioxidant vitamin supplementation on resistance exercise induced lipid peroxidation in trained and untrained participants [abstract].

Lipids Health Dis ; 3: Teixeira VH, Valente HF, Casal SI, et al. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Med Sci Sports Exerc ; 41 9 : — Bloomer RJ, Canale RE, Blankenship MM, et al.

Effect of ambrotose AO R on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults [abstract]. Nutr J ; 9: Gaeini AA, Rahnama N, Hamedinia MR. Effects of vitamin E supplementation on oxidative stress at rest and after exercise to exhaustion in athletic students.

J Sports Med Phys Fitness ; 46 3 : — Cholewa J, Poprzecki S, Zajac A, et al. The influence of vitamin C on blood oxidative stress parameters in basketball players in response to maximal exercise.

Sci Sports ; 23 : — Nieman DC, Henson DA, McAnulty SR, et al. Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon. J Appl Physiol ; 92 5 : —7. Braun B, Clarkson PM, Freedson PS, et al. Effects of coenzyme Q10 supplementation on exercise performance, VO2max, and lipid peroxidation in trained cyclists.

Int J Sport Nutr ; 1 4 : — Vasankari T, Kujala U, Vasankari T, et al. Increased serum and low-density-lipoprotein antioxidant potential after antioxidant supplementation in endurance athletes. Am J Clin Nutr ; 65 4 : —6. Meijer EP, Goris AH, Senden J, et al. Antioxidant supplementation and exercise-induced oxidative stress in the year-old as measured by antipyrine hydroxylates.

Br J Nutr ; 86 5 : — McAnulty SR, McAnulty LS, Nieman DC, et al. Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise.

J Nutr Biochem ; 16 9 : —7. Lamprecht M, Hofmann P, Greilberger JF, et al. Increased lipid peroxidation in trained men after 2 weeks of antioxidant supplementation.

Int J Sport Nutr Exerc Metab ; 19 4 : — Childs A, Jacobs C, Kaminski T, et al. Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise. Free Radic Biol Med ; 31 6 : — Vitamin E and immunity after the Kona Triathlon World Championship.

Med Sci Sports Exerc ; 36 8 : — Jakeman P, Maxwell S. Effect of antioxidant vitamin supplementation on muscle function after eccentric exercise. Eur J Appl Physiol Occup Physiol ; 67 5 : — Palazzetti S, Rousseau AS, Richard MJ, et al. Antioxidant supplementation preserves antioxidant response in physical training and low antioxidant intake.

Br J Nutr ; 91 1 : 91— Nakhostin-Roohi B, Babaei P, Rahmani-Nia F, et al. J Sports Med Phys Fitness ; 48 2 : — Bloomer RJ, Goldfarb AH, McKenzie MJ, et al. Effects of antioxidant therapy in women exposed to eccentric exercise.

Int J Sport Nutr Exerc Metab ; 14 4 : — Bryer SC, Goldfarb AH. Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise.

Int J Sport Nutr Exerc Metab ; 16 3 : — Nieman DC, Peters EM, Henson DA, et al. Influence of vitamin C supplementation on cytokine changes following an ultramarathon. J Interferon Cytokine Res ; 20 11 : — Phillips T, Childs AC, Dreon DM, et al.

A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Med Sci Sports Exerc ; 35 12 : —7. Funes L, Carrera-Quintanar L, Cerdán-Calero M, et al.

Eur J Appl Physiol ; 4 : — Peters EM, Anderson R, Nieman DC, et al. Vitamin C supplementation attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory polypeptides following ultramarathon running.

Int J Sports Med ; 22 07 : — Senturk UK, Yalcin O, Gunduz F, et al. Effect of antioxidant vitamin treatment on the time course of hematological and hemorheological alterations after an exhausting exercise episode in human subjects.

J Appl Physiol ; 98 4 : —9. Shafat A, Butler P, Jensen RL, et al. Effects of dietary supplementation with vitamins C and E on muscle func- tion during and after eccentric contractions in humans. Eur J Appl Physiol Oct; 93 : — Matsumoto H, Takenami E, Iwasaki-Kurashige K, et al.

Effects of blackcurrant anthocyanin intake on peripheral muscle circulation during typing work in humans. Eur J Appl Physiol ; 94 1 : 36— Mizuno K, Tanaka M, Nozaki S, et al. Antifatigue effects of coenzyme Q10 during physical fatigue.

Nutrition ; 24 4 : —9. Matuszczak Y, Farid M, Jones J, et al. Effects of Nacetylcysteine on glutathione oxidation and fatigue during handgrip exercise. Muscle Nerve ; 32 5 : —8. Reid MB, Stokić DS, Koch SM, et al. N-acetylcysteine inhibits muscle fatigue in humans. J Clin Invest ; 94 6 : — Mastaloudis A, Traber MG, Carstensen K, et al.

Antioxidants did not prevent muscle damage in response to an ultramarathon run. Med Sci Sports Exerc ; 38 1 : 72— Dawson B, Henry GJ, Goodman C, et al. Effect of vitamin C and E supplementation on biochemical and ultrastructural indices of muscle damage after a 21 km run.

Int J Sports Med ; 23 1 : 10—5. Traber MG. Relationship of vitamin E metabolism and oxidation in exercising human subjects. Br J Nutr ; 96 Suppl. S1: S34—7. Connolly DA, Lauzon C, Agnew J, et al. The effects of vitamin C supplementation on symptoms of delayed onset muscle soreness.

J Sports Med Phys Fitness ; 46 3 : —7. Rahmani-Nia F, Talebi E, Nakhostin-Roohi B, et al. Effect of two regimes of vitamin C on delayed onset of muscle soreness [special issue]. J Mov Sci Sports ; 5 1 : 1—5. Close GL, Ashton T, Cable T, et al.

Ascorbic acid supplementation does not attenuate post-exercise muscle soreness following muscle-damaging exercise but may delay the recovery process. Br J Nutr ; 95 5 : — Thompson D, Williams C, Garcia-Roves P, et al. Postexercise vitamin C supplementation and recovery from demanding exercise.

Eur J Appl Physiol May; 89 : — Ganio MS, Armstrong LE, Johnson EC, et al. Effect of quercetin supplementation on maximal oxygen uptake in men and women. J Sports Sci ; 28 2 : —8. Mastaloudis A, Morrow JD, Hopkins DW, et al. Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners.

Free Radic Biol Med ; 36 10 : — Nieman DC, Henson DA, Gross SJ, et al. Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc ; 39 9 : —9.

Avery NG, Kaiser JL, Sharman MJ, et al. Effects of vitamin E supplementation on recovery from repeated bouts of resistance exercise. J Strength Cond Res ; 17 4 : —9. Sharman IM, Down MG, Sen RN.

The effects of vitamin E and training on physiological function and athletic performance in adolescent swimmers. Br J Nutr ; 26 2 : — Lawrence J, Bower R, Riehl W, et al. Effects of alphatocopherol acetate on the swimming endurance of trained swimmers.

Am J Clin Nutr ; 28 3 : —8. Patil SM, Chaudhuri D, Dhanakshirur GB. Role of alphatocopherol in cardiopulmonary fitness in endurance athletes, cyclists. Ind J Physiol Pharmacol ; 53 4 : —9. Oostenbrug GS, Mensink RP, Hardeman MR, et al. Exercise performance, red blood cell deformability, and lipid peroxidation: effects of fish oil and vitamin E.

Buchman AL, Killip D, Ou CN, et al. Short-term vitamin E supplementation before marathon running: a placebocontrolled trial. Nutrition ; 15 4 : — Nalbant O, Toktas N, Toraman NF, et al. Vitamin E and aerobic exercise: effects on physical performance in older adults.

Aging Clin Exp Res ; 21 2 : — Porter DA, Costill DL, Zachwieja JJ, et al. The effect of oral coenzyme Q10 on the exercise tolerance of middleaged, untrained men.

Int J Sports Med ; 16 7 : —7. Zhou S, Zhang Y, Davie A, et al. Muscle and plasma coenzyme Q10 concentration, aerobic power and exercise economy of healthy men in response to four weeks of supplementation. J Sports Med Phys Fitness ; 45 3 : — Cureton KJ, Tomporowski PD, Singhal A, et al.

Dietary quercetin supplementation is not ergogenic in untrained men. J Appl Physiol ; 4 : — Dumke CL, Nieman DC, Utter AC, et al.

Appl Physiol Nutr Metab ; 34 6 : — J Gerontol A Biol Sci Med Sci ; 65 8 : — Marshall RJ, Scott KC, Hill RC, et al. Supplemental vitamin C appears to slow racing greyhounds.

J Nutr Jun; 6 Suppl. Weight LM, Myburgh KH, Noakes TD. Vitamin and mineral supplementation: effect on the running performance of trained athletes. Am J Clin Nutr ; 47 2 : —5. McAnulty SR, Nieman DC, Fox-Rabinovich M, et al.

Effect of n-3 fatty acids and antioxidants on oxidative stress after exercise. Med Sci Sports Exerc ; 42 9 : — Nielsen AN, Mizuno M, Ratkevicius A, et al. No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue.

Int J Sports Med ; 20 3 : —8. Snider IP, Bazzarre TL, Murdoch SD, et al. Effects of coenzyme athletic performance system as an ergogenic aid on endurance performance to exhaustion.

Int J Sport Nutr ; 2 3 : — Arent SM, Pellegrino JK, Williams CA, et al. Nutritional supplementation, performance, and oxidative stress in college soccer players. J Strength Cond Res ; 24 4 : — Fry AC, Bloomer RJ, Falvo MJ, et al. Res Sports Med ; 14 1 : 53— Knechtle B, Knechtle P, Schulze I, et al.

Vitamins, minerals and race performance in ultra-endurance runners: Deutschlandlauf Asia Pac J Clin Nutr ; 17 2 : —8. Yfanti C, Akerstrom T, Nielsen S, et al. Antioxidant supplementation does not alter endurance training adaptation. Med Sci Sports Exerc ; 42 7 : — Ylikoski T, Piirainen J, Hanninen O, et al.

The effect of coenzyme Q10 on the exercise performance of crosscountry skiers. Mol Aspects Med ; 18 Suppl. Bonetti A, Solito F, Carmosino G, et al. Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects.

Ahtletes of the International Society of Sports Nutrition volume Forskolin and body compositionArticle number: 4 Cite this article. Metrics details. Suppldments aim of this commentary was to discuss the last studies regarding Antioxidabt effect Blueberry pastry recipes antioxidant vitamins Scientific weight control Antixidant oxidative stress in exercise in humans. The inclusion criteria encompassed published studies done in adult males and females between and The keywords used in the search engine were: endurance athlete, diet, oxidative stress, physical activity, diet, nutrition, antioxidant, antioxidant status, vitamin C, vitamin A, vitamin E, β-carotene and combinations. Twelve studies were identified and organized according to the methodology and results of supplementation: ergogenic, ergolytic, partial or no difference between groups. It is concluded that supplementation with antioxidant vitamins has controversial effects to oxidative damage induced by endurance exercise.

High athletws of reactive oxygen Blueberry pastry recipes ROS produced in skeletal muscle during exercise have been associated with muscle damage Antkoxidant impaired muscle ayhletes. Antioxidant supplements for athletes endogenous defence systems with additional Reduce midsection fat doses Corporate wellness programs antioxidants xupplements received much attention as a noninvasive strategy to prevent or reduce oxidative stress, decrease muscle damage and improve exercise performance.

Over articles have xthletes published EGCG and skin health this topic, with almost all of these being Natural athletic supplements, low-quality studies.

The consistent finding is that antioxidant supplementation attenuates Maintains optimal digestive function oxidative stress. However, any physiological implications of this have yet to be consistently demonstrated, with most studies reporting no effects Blueberry pastry recipes exercise- induced muscle damage and performance.

Moreover, Antioxidant supplements for athletes growing body of evidence indicates detrimental effects of antioxidant supplementation on the health and performance benefits of exercise training. Indeed, supppements ROS are associated with Scientific weight control biological events, they are also essential to the aathletes and optimal function of every cell.

The aim of this review is to present and discuss 23 studies that have shown that antioxidant supplementation interferes with exercise training-induced adaptations.

The Antioxiant findings of these studies are that, in certain situations, loading the cell with high doses of antioxidants leads to a blunting of the positive effects of Antiooxidant training and interferes with important ROS-mediated physiological Ahtioxidant, such as vasodilation and insulin signalling.

Suppllements research is Scientific weight control to produce evidence-based guidelines regarding the use of antioxidant Antioxidant supplements for athletes during exercise training.

We recommend that an adequate intake of vitamins and minerals through a Fat-burning plyometric exercises and Carbohydrate Digestion diet remains the best approach to supplsments the optimal antioxidant status in exercising individuals.

This is a preview atnletes subscription content, log in supp,ements an institution to Antioxidantt access. Rent this article via Supplemetns. Institutional subscriptions. Maughan RJ, Antioxidant supplements for athletes F, Geyer H. The use of dietary supplements by athletes. J Sports Sci ; 25 Suppl.

Article Google Scholar. Atalay M, Lappalainen J, Sen CK. Dietary antioxidants for the athlete. Curr Sports Med Rep Supplemnts 5 4 : —6. PubMed Google Scholar. Clarkson PM, Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr Aug; 72 2 Suppl.

Google Scholar. Kanter M. Free radicals, exercise and antioxidant supplementation. Proc Nutr Soc Feb; 57 1 : 9— Antioixdant PubMed CAS Google Scholar.

Margaritis I, Rousseau AS. Does physical exercise modify antioxidant requirements? Nutr Res Rev Jun; 21 1 : 3— McGinley C, Shafat A, Donnelly AE. Does antioxidant vitamin supplementation protect against muscle damage?

Sports Med ; 39 12 : — Article PubMed Google Scholar. Urso ML, Clarkson PM. Oxidative stress, exercise, and antioxidant supplementation. Toxicology Jul 15; : 41— Williams SL, Strobel NA, Lexis LA, et al.

Antioxidant requirements of endurance athletes: implications for health. Nutr Rev Mar; 64 3 : 93— Clarkson PM, Hubal MJ. Exercise-induced muscle damage in humans. Am J Phys Med Rehabil Nov; 81 11 Suppl. Peake JM, Suzuki K, Coombes JS. The influence of antioxidant supplementation onmarkers of inflammation and the relationship to oxidative fr after exercise.

J Nutr Biochem Jun; 18 6 : — Powers SK, DeRuisseau KC, Quindry J, et al. Dietary antioxidants and exercise. J Sports Sci Jan; 22 1 : 81— Farbstein D, Kozak-Blickstein A, Levy AP.

Antioxidant vitamins and their use fof preventing cardiovascular disease. Molecules ; 15 11 : — Stanner SA, Hughes J, Kelly CN, et al.

Public Health Nutr May; 7 3 : — Willcox BJ, Curb JD, Rodriguez BL. Antioxidants in cardiovascular health and disease: key athleges from epidemiologic studies. AmJ Cardiol May 22; 10A : D75— Article Antikxidant Google Scholar.

Han-Yao H, Caballero B, Chang S, et al. The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health State-of-the- Science Conference.

Ann Intern Med ; 5 : — Stocker R, Keaney JF. Role of oxidative modifications in atherosclerosis. Physiol Rev ; 84 4 : — Devasagayam Arhletes, Tilak JC, Boloor KK, et al. Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians ; — CAS Google Scholar.

Kohen R, Nyska A. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol ; 30 6 : — Jacob C, Winyard PG, editor. Redox signaling and regulation in biology and medicine.

Weinheim: Wiley-VCH, Book Google Scholar. Athleted Z, editor. Free radicals in exercise and aging. Champaign IL : Human Kinetics, St-Pierre J, Buckingham JA, Roebuck SJ, et al.

Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem Nov 22; 47 : — Boveris A, Chance B.

The mitochondrial generation of hydrogen peroxide: general properties and effect of hyperbaric oxygen. Biochem J Jul; 3 : — PubMed CAS Google Scholar. Boveris A, Oshino N, Chance B. The cellular production of hydrogen aghletes. Powers SK, Jackson Atnioxidant. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production.

Physiol Rev Oct; 88 4 : — Aruoma OI, Halliwell B, Gajewski E, et al. Copper-iondependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem J Feb 1; Pt3 : —4.

Halliwell B. Phagocyte-derived reactive species: salvation or suicide? Trends Biochem Sci Sep; 31 9 : —

: Antioxidant supplements for athletes

Antioxidant Supplementation during Exercise Training | Sports Medicine	The only form of vitamin E that has been tested under conditions of exercise is alpha-tocopherol. New findings clearly indicate that alpha-tocopherol may have some adverse effects under certain conditions and that the other natural forms of vitamin E have functions distinct from the effects of alpha-tocopherol. For example, alpha-tocotrienol is significantly more neuroprotective than alpha-tocopherol. When considering the cellular mechanisms, current knowledge supports the role of antioxidant nutrients in the intracellular management of excess ROS. Several physiological and pathological conditions ranging from pregnancy to cardiovascular disease and cancer have been studied to elucidate the effects of antioxidant supplementation. Copyright: © The Authors. This is an open access article under the terms of the Creative Commons Attribution NonCommercial ShareAlike 4. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. E-ISSN: Contact Home. Submit Paper. Indexed In CAS Source Index CASSI Google Scholar Directory of Research Journal Indexing DRJI EBSCO A-Z Publons International committee of medical journals editors ICMJE Euro Pub ASI Dahlgren Memorial Library View More. Lexis, Jeff S. This review discusses studies investigating the effects of antioxidant supplementation on exercise-induced oxidative stress with a focus on the health implications. The aim is to determine antioxidant requirements for endurance athletes. Overall, differences in methodology make it difficult to compare the relatively small number of published studies on this topic. The types of studies needed to more adequately assess the health effects of antioxidant supplements in athletes long-term interventions with hard end points have not been done. Therefore, there is currently insufficient evidence to recommend antioxidant supplements for endurance athletes. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Navbar Search Filter Nutrition Reviews This issue Dietetics and Nutrition Books Journals Oxford Academic Mobile Enter search term Search. Issues More Content Advance articles Editor's Choice Supplement Archive Podcasts Article Collection Archive Submit Author Guidelines Submission Site Open Access Call for Papers Why Publish? Purchase Alerts About About Nutrition Reviews About International Life Sciences Institute Editorial Board Early Career Editorial Board Advertising and Corporate Services Journals Career Network Self-Archiving Policy Journals on Oxford Academic Books on Oxford Academic. Purchase Alerts About About Nutrition Reviews About International Life Sciences Institute Editorial Board Early Career Editorial Board Advertising and Corporate Services Journals Career Network Self-Archiving Policy Close Navbar Search Filter Nutrition Reviews This issue Dietetics and Nutrition Books Journals Oxford Academic Enter search term Search. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Journal Article. Antioxidant Requirements of Endurance Athletes: Implications for Health. Williams, BSc Hons , Sarah L. Williams, BSc Hons. Exercise and Oxidative Stress Research Group, School of Human Movement Studies, University of Queensland, St. Lucia, Queensland, Australia, The age range of the participants varied from 16 to 55 years. Although we found antioxidant supplementation may very slightly reduce muscle soreness in the first three days after exercise, these reductions were so small, it was unlikely they made any difference at all. So ultimately, we found that high dose antioxidant supplementation — in excess of the normal recommended daily dose for antioxidants — does not appear to reduce muscle soreness after exercise. Of the studies we looked at, only nine reported on adverse effects. Two of these found some people who took antioxidants experienced gastrointestinal distress — such as diarrhoea, indigestion and bloating. On top of our findings, more recently, there has been an emergence of studies showing that chronic antioxidant supplementation may actually be counterproductive. For instance, it has been shown that antioxidant supplements may delay healing and recovery from exercise , hinder adaptations to training , and may even increase mortality. Taking all of this into consideration, the main take home message is to steer clear of antioxidants supplements and save your money. Instead, just try and move more, exercise regularly, and eat a balanced diet that includes at least five or more portions of rainbow coloured fruits and vegetables. Because for now at least, there is no quick fix to easing muscle soreness after exercise. In fact, it seems muscle soreness is an important part of the recovery process and can help to make your muscles stronger and bigger over time. And that will ultimately help to make you fitter and stronger in the long run. Menu Close Home Edition Africa Australia Brasil Canada Canada français España Europe France Global Indonesia New Zealand United Kingdom United States.
Beyond Antioxidants	Yfanti C, Fischer CP, Nielsen S, Akerstrom T, Nielsen AR, Veskoukis AS, Kouretas D, Lykkesfeldt J, Pilegaard H, Pedersen BK: Role of vitamin C and E supplementation on IL-6 in response to training. Tauler P, Aguilo A, Gimeno I, Fuentespina E, Tur JA, Pons A: Response of blood cell antioxidant enzyme defences to antioxidant diet supplementation and to intense exercise. Eur J Nutr. Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre J, Vina J: Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. CAS PubMed Google Scholar. Nalbant O, Toktas N, Toraman NF, Ogus C, Aydin H, Kacar C, Ozkaya YG: Vitamin E and aerobic exercise: effects on physical performance in older adults. Aging Clin Exp Res. Gauche E, Lepers R, Rabita G, Leveque JM, Bishop D, Brisswalter J, Hausswirth C: Vitamin and mineral supplementation and neuromuscular recovery after a running race. Med Sci Sports Exerc. Nielsen HG, Skjonsberg OH, Lyberg T: Effect of antioxidant supplementation on leucocyte expression of reactive oxygen species in athletes. Scand J Clin Lab Invest. Patil SM, Chaudhuri D, Dhanakshirur GB: Role of alpha-tocopherol in cardiopulmonary fitness in endurance athletes, cyclists. Indian J Physiol Pharmacol. Louis J, Hausswirth C, Bieuzen F, Brisswalter J: Vitamin and mineral supplementation effect on muscular activity and cycling efficiency in master athletes. Appl Physiol Nutr Metab. Bloomer RJ, Falvo MJ, Schilling BK, Smith WA: Prior exercise and antioxidant supplementation: effect on oxidative stress and muscle injury. J Int Soc Sports Nutr. Article PubMed Central PubMed Google Scholar. Yfanti C, Akerstrom T, Nielsen S, Nielsen AR, Mounier R, Mortensen OH, Lykkesfeldt J, Rose AJ, Fischer CP, Pedersen BK: Antioxidant supplementation does not alter endurance training adaptation. J Sports Med Phys Fitness. Lamprecht M, Greilberger J, Oettl K: Analytical aspects of oxidatively modified substances in sports and exercises. Download references. VP Research Institute, Rua Pedro Morganti, Vila Mariana, PO Box , São Paulo, SP, Brazil. You can also search for this author in PubMed Google Scholar. Correspondence to Humberto Nicastro. CLD participate in the manuscript design and wrote the first draft of the manuscript. AN, NM, ANB, RAC, and VP participated in the interpretation and preparation of the manuscript. HN participated in the manuscript design, interpretation and preparation of the manuscript. All the authors read and approved the final manuscript. Open Access This article is published under license to BioMed Central Ltd. Reprints and permissions. Draeger, C. et al. Controversies of antioxidant vitamins supplementation in exercise: ergogenic or ergolytic effects in humans?. J Int Soc Sports Nutr 11 , 4 Download citation. Received : 09 October Accepted : 12 February Published : 19 February Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. One of the things I was asked about was antioxidant supplementation, and my advice was that, generally, it was best to stay clear from both a health and performance perspective. As I left that meeting, I felt a bit uneasy. This article is the result of me revisiting this information, and it therefore acts as an update to my article from When we exercise, we produce reactive oxygen species ROS —often referred to as free radicals—as a consequence of metabolism within the mitochondria, and also muscle contraction. These ROS are highly reactive, so they can damage structures they come into contact with, such as the walls of our cells, and also interfere with normal cellular function. This, in turn, contributes to fatigue, immune dysfunction, and muscle damage, all of which are harmful to sports performance. Antioxidants help to buffer these ROS, reducing the damage they can cause and mitigating the increases seen in fatigue and immune dysfunction after exercise. There are two main types of antioxidants: endogenous and exogenous. The endogenous antioxidants are produced by our body, which has evolved over the years a very competent system to mitigate oxidative stress. Exogenous antioxidants come from the diet. Exogenous antioxidants can come from food sources, or from dietary supplements. My first question, then, is: Do antioxidant supplements improve our health? To answer this question, I will mostly look at meta-analyses and review articles. Meta-analyses combine the data from a number of studies, and so give a good idea of the overall research in a particular area. The first meta-analysis I want to introduce comes from , and is comprised of , subjects, which is a lot of participants. The aim of the study was to see whether antioxidant supplements had any effect on mortality. Overall, the results indicated that these supplements had no effect on mortality—i. Further analysis of the trials allowed the researchers to separate those at low risk of bias. In doing so, the data indicated that beta carotene, vitamin A, and vitamin E, either together or individually, increased the risk of death. Vitamin C had no significant effect. An earlier study looking specifically at gastro-intestinal cancers found that antioxidant supplementation did not prevent these cancers , but instead appeared to increase their incidence. A paper found that high-dose vitamin E supplementation might increase risk of death from all causes, and should be avoided. This more or less replicated the results from a meta-analysis. Another meta-analysis found no effect of antioxidant supplementation on cancer incidence , unless you were a smoker—in which case beta-carotene supplementation increased your cancer risk. So antioxidant supplementation appears to be at best neutral, and quite possibly negative in regards to health. However, it is also well-established that low levels of antioxidants within the blood are associated with increased risks of death. For example, an older study from conducted on almost 3, men in Switzerland found that overall cancer mortality was associated with lower plasma levels of carotenes and vitamin C , such that being in the lowest quartile for antioxidant intake could increase disease risk by almost a factor of three. Higher plasma levels of lycopene, an antioxidant found in tomatoes, are associated with a decreased risk of prostate cancer. This is curious; we clearly need antioxidants within our bloodstream to keep us healthy, but antioxidant supplementation appears to be unhealthy, or at best neutral. Why is this? Well, as with most things, the dose makes the poison. Antioxidant supplements tend to contain doses of antioxidants far higher than what would naturally be found. For example, in one of the vitamin E studies above, it was high-dose vitamin E supplementation that was unhealthy. Supra-physiological doses of antioxidants, in the form of supplements, appear to be at best neutral in terms of health. However, antioxidants from natural sources appear to be healthful, in part because the doses are kept low. In addition to this, antioxidants from food often come with complementary nutrients, which can synergistically work to improve health. High-dose antioxidant supplements often come with few additional nutrients, which in turn can increase the amount of ROS present in the body, causing further damage—as illustrated by the potential increase in mortality seen in the high-dose antioxidant supplementation trials. This is further evidenced by the protective effect of higher intakes of vegetables and fruits foods that contain the greatest amount of antioxidants on both cancer and all-cause mortality risk. Studies one , two , three , four , five , six , and seven. Sports Med. Peternelj TT, Coombes JS. Antioxidant supplementation during exercise training: beneficial or detrimental? Myung SK, Ju W, Cho B, et al. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. Ha V, de Souza RJ. J Am Heart Assoc. Yarahmadi M, Askari G, Kargarfard M, et al. The effect of anthocyanin supplementation on body composition, exercise performance and muscle damage indices in athletes. Int J Prev Med. Howatson G, McHugh MP, Hill JA, et al. Influence of tart cherry juice on indices of recovery following marathon running. Scand J Med Sci Sports. Lansley KE, Winyard PG, Bailey SJ, et al. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc. Rienks JN, Vanderwoude AA, Maas E, Blea ZM, Subudhi AW. Effect of beetroot juice on moderate-intensity exercise at a constant rating of perceived exertion. Int J Exerc Sci. Fisher ND, Hurwitz S, Hollenberg NK. Habitual flavonoid intake and endothelial function in healthy humans. J Am Coll Nutr. Patel RK, Brouner J, Spendiff O. Dark chocolate supplementation reduces the oxygen cost of moderate intensity cycling. J Int Soc Sports Nutr. Beets and chocolate are great together, as they both have deep, earthy flavors and are antioxidant rich. Note that this recipe calls for 'cacao powder,' which isn't the same as cocoa powder. Cacao powder is much richer because it still contains the fatty acids from the bean, though it's harder to find try health food stores, specialty shops, or online companies. Cocoa powder will work as a substitute, but the texture will be different. The fat content of the recipe also will be reduced. Directions 1. Bring all ingredients, except the cacao powder, lemon juice, and scallions, to a boil in a large soup pot. Lower the heat to a simmer and cook for 20 minutes. Stir in the cacao powder and cook for another 20 minutes. Stir occasionally during this time. Add the lemon juice and remove from the heat. Serve with the scallions and any other accompaniments you wish. Variations: Mix up the ingredients for this soup by adding 1 cup chopped cabbage, 1 minced chile pepper, 1 cup sliced mushrooms, or 1 cup diced tempeh to the pot. Garnish with grated chocolate on each bowl before serving. Nutrient Analysis per serving Calories: ; Total fat: 4 g; Sat fat: 2 g; Trans fat: 0 g; Sodium: mg; Total carbohydrate: 42 g; Dietary fiber: 8 g; Sugars: 17 g; Protein: 6 g. Home About Events Resources Contact Advertise Job Bank Writers' Guidelines Search Gift Shop.
Don’t waste your time taking antioxidant supplements after exercise	Vina J, Gomez-Cabrera MC, Borras C. Exogenous antioxidants can come from food sources, or from dietary supplements. Vasankari T, Kujala U, Sarna S, et al. With wider blood vessels, more oxygen-rich blood flows through the body and reaches muscles sooner; this allows muscles to work at a high intensity for longer periods of time. I: general aspects J Biol Chem Jul 15; 20 : — CAS Google Scholar Halliwell B, Chirico S. J Sports Sci ; 25 11 : —
What Endurance Athletes Should Know About Antioxidants – Triathlete	The last study only contained partial results. Braun H, Koehler K, Geyer H, et al. Williams, BSc Hons. Am J Clin Nutr ; 87 1 : —9 PubMed CAS Google Scholar Khassaf M, McArdle A, Esanu C, et al. Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men. They're calorically dense, so educating clients about appropriate serving size is important. Nutr Res ; 28 6 : —

Two years ago, I wrote Blueberry pastry recipes article for Freelap on whether Antiooxidant supplementation was a good supplememts for athletes. I presented aathletes that illustrated how long-term supplementation with high doses of Anrioxidant likely has a xupplements effect Natural chia seeds training outcomes, Blueberry pastry recipes exercise-induced Scientific weight control, and potentially negatively impacting recovery speed. My conclusion was that, on the whole, athletes should probably avoid antioxidant supplementation during training phases. A few weeks ago, I was at a high-level sports club, discussing with them changes they could make in their training. One of the things I was asked about was antioxidant supplementation, and my advice was that, generally, it was best to stay clear from both a health and performance perspective. As I left that meeting, I felt a bit uneasy.