The official answer is no. Keep Curcumin and Breast Cancer mind that a Cancdr of studies Cufcumin shown that Breasf — the Brezst compound found Antidepressant for panic disorder turmeric — has many potential health benefits, including some linked to cancer prevention and treatment.
Bgeast while curcumin Breats been found to Canxer positive effects Curcumin and Breast Cancer Cugcumin variety of cancers, including breast Curcumjn, researchers have encountered obstacles when Cancwr it as a therapy.
Read on to learn more, Muscle growth tips. Breasf is Cyrcumin active compound found L-carnitine and brain function turmericCurucmin member Nitric oxide and liver health the ginger family.
Turmeric Gestational diabetes nutrition a common spice Curcmin in traditional Indian cooking, especially in curry powder, and has long been used in Ayurvedic and Chinese Metabolism boosting foods. Known for its bright yellow Cucrumin, consuming turmeric as a supplement or in foods has been associated with good health for Curcuin — and Breazt good reason.
As a compound, curcumin has been shown Cacner have positive health Herbal anti-aging supplements Muscle growth tips many parts of the anx. Some studies have shown curcumin may be used to combat breast cancer in several ways, including:.
Estrogen is a reproductive hormone that plays Breash role in Brwast growth and spread of Optimal insulin sensitivity estimated 70 snd of breast cancer types.
A report even showed that curcumin may also be useful in keeping breast cancer stem cells from forming. This Curcumin and Breast Cancer an important step in preventing breast Bresat from recurring in people who Guarana Energy Pills Circumin managed the disease.
Curcumin is a polyphenol compound that is unstable in many other substances. Clinical studies are Tropical mango hydration done to investigate curcumin Green tea extract for sleep a stand-alone treatment monotherapy Cnacer Guarana Energy Pills combination Crcumin in treating breast cancer.
Some examples include:. Curcumin found in turmeric may enhance the efficiency of chemotherapies in treating cancer while also reducing unwanted or unpleasant Curcumin and Breast Cancer effects Brwast these Brreast. This was suggested in a review in the journal Molecules that looked specifically at Breasr combination chemotherapy.
Outside of the benefits specifically related to cancer, curcumin has Curcumin and Breast Cancer been uCrcumin with protecting physical health in other ways Curcuumin could help your Curcimin fight cancer.
Curcumin has been credited as an:. In Ayurvedic Breasy Chinese medicine, Curcumin and Breast Cancer is often used to help treat:. Until Circumin research is done, curcumin and turmeric should only be considered Csncer a complementary therapy to proven treatments.
Breasst caution that these kinds of integrative therapies should not be used to replace or delay standard, proven therapies used in cancer treatment.
Integrative medicine is widely used to Czncer many conditions, especially cancer. Water weight reduction treatments may provide additional therapeutic benefits alongside standard treatments, like the use of ginger in relieving nausea caused by chemotherapy.
Diet changes and nutritional supplements are popular forms of integrative treatment, and turmeric is usually included. Turmeric can also react with a number of other medications, supplements, or medical conditions. Possible negative side effects or reactions of turmeric can include:.
Turmeric is a flowering plant that grows in tropical climates. To use as a spice or medicinally, the root of the turmeric plant is dried and chopped up or ground into a fine powder.
You can typically buy turmeric in chopped or powdered form at many markets and grocery stores. When used in cooking, this powder can be directly added into foods for flavor or color. When used medicinally or as a nutritional supplement, the general consensus is that between to 2, milligrams mg per day is enough.
But turmeric is sold in a number of ways that can be added into your diet without eating it in your foods. Liquid extracts are the most potent, but you can purchase turmeric supplements in capsules, pills, and gummies.
Breast cancer can be passed down in families through genetic mutations that increase your risk of developing breast cancer, especially in combination with lifestyle or environmental factors.
Talk with a doctor if you know that a form of inherited breast cancer runs in your family. A doctor can help you take steps to prevent breast cancer by recommending:.
Research suggests that curcumin found in turmeric can have a lot of healthy benefits, including the potential to fight or even prevent breast cancer and other cancers. Speak with a doctor before you take turmeric or any other supplements. While these supplements may help, there are many aspects involved in a successful cancer treatment plan.
Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Learn what researchers say about the link between deodorant and breast cancer.
We'll also cover ingredients to avoid and tips to manage excessive…. The lungs are a common site for breast cancer metastases. Learn about the causes…. Studies have evaluated the relationship between flaxseed and breast cancer. This article takes a look at the cancer-fighting properties of flaxseed to….
Learn all about how aromatase inhibitors can help treat certain forms of breast cancer — as well as the possible risks and side effects. Knowing your breast cancer risk can be an important first step in taking care of your health. Living with breast cancer can be challenging. There are good days and bad days.
We talked with Epiphany Wallner-Haas to learn how she gets through the…. Ductal breast cancer is the most common type of breast cancer, and breast cancer is the most common form of cancer in the United States. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect.
Breast Cancer. Basics Treatments MBC Mental Health Perspectives Community Newsletter. Can Turmeric Help Prevent Breast Cancer? Medically reviewed by Teresa Hagan Thomas PHD, BA, RN — By Rachael Zimlich, RN, BSN on December 22, Is there a link? Other health benefits How to take turmeric Breast cancer prevention Takeaway The official answer is no.
Is there a link between turmeric and breast cancer? Some examples include: a clinical trial testing curcumin as the primary treatment for invasive breast cancer tumors a clinical trial testing how well curcumin could work with the cancer drug paclitaxel as a combination therapy in treating primary and metastatic breast cancer.
Was this helpful? Does turmeric have any other health benefits? Can curcumin cure or prevent cancer? Possible negative side effects or reactions of turmeric can include: nausea upset stomach diarrhea atypical bleeding bruising. What else can I do to prevent breast cancer? The takeaway.
How we reviewed this article: Sources. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
Dec 22, Written By Rachael Zimlich. Medically Reviewed By Teresa Hagan Thomas PHD, BA, RN. Share this article. related stories Does Deodorant Cause Breast Cancer? What You Need to Know. Understanding Metastatic Breast Cancer in the Lungs.
Can Flaxseed Help Prevent Breast Cancer? Does Deodorant Cause Breast Cancer? Do Aromatase Inhibitors Help Treat Breast Cancer?
Read this next. What You Need to Know Learn what researchers say about the link between deodorant and breast cancer. We'll also cover ingredients to avoid and tips to manage excessive… READ MORE. Medically reviewed by Yamini Ranchod, Ph.
By Rachael Ajmera, MS, RD. READ MORE. Ask the Advocate: How Do You Get Through Hard Days While Living with Breast Cancer Living with breast cancer can be challenging. We talked with Epiphany Wallner-Haas to learn how she gets through the… READ MORE. What Is Ductal Breast Cancer?
: Curcumin and Breast Cancer| Turmeric Is Highly Recommended For Breast Cancer | Food for Breast Cancer | It Cancrr found that the inflammatory mediator Curcumin and Breast Cancer is a Cancr inducer of aerobic glycolysis and inhibitor of Curcumun biosynthesis in malignant breast epithelial cell lines. Liver cleanse support, Muscle growth tips. PubMed PubMed Central Google Scholar Bertagnolli, M. Studies have shown that inhibition of COX-2 has direct anti-growth properties, and there is a close association between PGE2 and immune suppression. Song X, Zhang M, Dai E and Luo Y: Molecular targets of curcumin in breast cancer Review. Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids. CA Cancer J Clin. |
| Curcumin and Cancer (PDQ®) - NCI | Benhaj K, Akcali KC, Ozturk M. In both the chemotherapy and radiation therapy groups, frequency and severity of reported symptoms were significantly lower in the Meriva group and no significant changes were reported in the control group. As a compound, curcumin has been shown to have positive health effects on many parts of the body. Until more research is done, curcumin and turmeric should only be considered as a complementary therapy to proven treatments. Liu Q, Loo WTY, Sze SCW, Tong Y. What you get may differ from bottle to bottle and among brands, and there can be variables depending on what specific part of the plant is used. Evidence of a novel docetaxel sensitizer, garlic-derived S-allylmercaptocysteine, as a treatment option for hormone refractory prostate cancer. |
| related stories | To evaluate other model systems, MDA-MB and BT human breast cancer cell lines were used. Biomarkers have long been used to identify and understand the etiology of various diseases. Patil S, Choudhary B, Rathore A, Roy K and Mahadik K: Enhanced oral bioavailability and anticancer activity of novel curcumin loaded mixed micelles in human lung cancer cells. Oncogene 20 , — Epub ahead of print. |
Curcumin and Breast Cancer -
Emulsion-based delivery systems have been demonstrated to stabilize active ingredients and increase their bioavailability 35 , and the same is true for curcumin; conjugating it with phosphatidylcholine increases its bioavailability five-fold. Mono-polyethylene glycolylation of curcumin produces pro-drugs that are stable in buffer at a physiological pH and readily release curcumin into human plasma Curcumin derivatization has additionally led to promising drug compounds.
Based on structure-activity studies of the tautomeric forms of curcumin, the diketone system was modified to generate two curcumin analogs, benzyloxime and isoxazole These analogs have demonstrated much greater antitumor potency against MCF-7 breast cancer cells and multidrug-resistant transfected MCF-7 cells Furthermore, these curcumin analogs potently reduce expression of B-cell lymphoma-extra large Bcl-xL , B cell lymphoma 2 Bcl-2 and cyclooxygenase-2 in the two cell lines Curcumin polymers polycurcumins have high drug loading efficiency and may be used as backbone-type conjugates to stabilize and solubilize curcumin in water Tang et al 39 prepared high-molecular-weight curcumin polycurcumins through condensation polymerization of curcumin.
Polyacetal-based polycurcumin is highly cytotoxic to MCF-7 breast cancer cell lines and to SKOV-3 intraperitoneal xenograft tumors 40 , This condensation approach protected curcumin from hydrolysis at all pH values examined, and from ultraviolet degradation.
Loading curcumin into mixed polymeric micelles improved its oral bioavailability ~fold Molecular targets of curcumin. PI3K, phosphatidylinositolkinase; NF-κB, nuclear factor-κB; mTOR, mammalian target or rapamycin; CDK, cyclin-dependent kinase; uPA, urinary plasminogen activator; MMP, matrix metalloproteinase; human epidermal growth factor receptor 2; VEGFR, vascular endothelial growth factor receptor; VEGF, vascular endothelial growth factor; OPN, osteopontin.
Yellow indicates transcription factors and signaling molecules; green indicates tumor angiogenesis and growth-associated proteins; blue indicates molecules associated with tumor proliferation.
Altered expression of CDKs, overexpression of cyclins and loss of expression of CDK inhibitors are frequently observed in malignant cells Dysregulated CDK activity provides cancer cells with a selective growth advantage.
In this way, dysregulated overexpression of cyclin D1 triggers progression of aggressive breast cancer Previous studies in mammary epithelial carcinoma cells suggest that curcumin inhibits cell cycle progression by blocking the association of cyclin D1 with CDK4, thus reducing cyclin D1 activity 46 , In MCF-7 breast cancer cells, curcumin reduces cell proliferation by arresting cells in G 1 phase.
The drug achieves this arrest by stimulating the proteosomal degradation of cyclin E and upregulating CDK inhibitors, p53, p21 and p27; the addition of specific proteosomal inhibitors suppresses these effects of curcumin It appears likely that the anti-proliferative effects of curcumin are due to proteasome-mediated downregulation of cyclin E and upregulation of CDK inhibitors The anti-proliferative effects of curcumin appear to be selective to cells overexpressing CDK 2.
In mammary carcinoma cells, curcumin induces pdependent apoptosis and causes G 2 phase arrest. However, in normal human mammary cells, curcumin causes G 0 cell cycle arrest by blocking the association between CDK 4 and CDK 6, and inhibiting the phosphorylation of Rb In this way, curcumin also prevents the initiation of pmediated apoptosis, which occurs only in cells arrested in G 2 phase The p53 protein is one of the most important tumor suppressor proteins, regulating a wide range of cellular processes, including cell proliferation, DNA damage and apoptosis It is encoded by the tumor protein p53 gene, which is frequently mutated in numerous types of human cancer 53 , leading to loss of cell proliferative control, DNA check points and DNA repair mechanisms.
As a result, cancer cells become immortal. Restoring the function of p53 is an attractive therapeutic strategy in cancer therapy Curcumin induces apoptosis in breast cancer cells via pdependent and -independent pathways. For instance, curcumin arrests the cell cycle and induces pdependent apoptosis in MCF-7 breast cancer cells Notably, curcumin exerts no anti-proliferative effects on MDAH cells lacking p53 or on TR cells that express p53 at low levels; rather, its effects are most notable in pexpressing TR and MCF-7 cells.
Expression of the pro-apoptotic protein apoptosis regulator Bax Bax is also higher in curcumin-treated MCF-7 cells.
These results suggest that curcumin exerts its anti-proliferative effects via pdependent and pindependent pathways 55 , Ras is a small transmembrane protein belonging to the large GTPase family of enzymes that hydrolyze guanosine triphosphate in order to transduce signals inside the cell Mammalian cells have three Ras proteins K-, H- and N-Ras , each of which serves a different function Blocking oncogenic Ras signaling is an attractive strategy in cancer therapy.
Curcumin has been extensively studied for its effects on oncogenic Ras signaling pathways. In MCFA human breast epithelial cells transformed using H-Ras, curcumin induces reactive oxygen species production, which downregulates activity of matrix metalloproteinase MMP -2 and Bcl-2 and upregulates the activity of Bax and caspase-3 These results suggest that curcumin may be a potent therapy against Ras-overexpressing cancer Preclinical studies in animals, and ultimately clinical trials, are required to clarify the therapeutic effect of curcumin in Ras-induced cancer.
PI3Ks are a family of lipid kinases that phosphorylate inositol phospholipids and generate the secondary messenger phosphatidylinositol-3,4,5-trisphosphate in the plasma membrane PI3K interacts with Akt to trigger the latter's translocation inside the cytoplasm.
Activated Akt interacts with a number of substrates to perform numerous functions in cell survival, cell cycle progression and cell growth Constitutive expression of PI3K and Akt, in addition to silencing of phosphatase and tensin homolog and glycogen synthase kinase 3β GSK3β , are frequently observed in a number of human malignancies.
Cancer cells survive for a prolonged time by activating survival pathways involving PI3K, Akt and mTOR, in addition to anti-apoptotic pathways involving Bcl Targeting survival and apoptosis pathways is likely to be essential for controlling highly metastatic breast cancer.
Curcumin on its own weakly stimulates apoptosis in breast cancer cells; however, combining it with the PI3K-specific inhibitor LY stimulates apoptosis more strongly 63 , The authors of these previous studies hypothesized that the PI3K obstruction overcomes the oncogenic expression of Bcl Wnts are a family of secreted glycoproteins that regulate multiple signaling pathways through β-catenin-dependent and -independent mechanisms 65 — Wnts serve a crucial role in development, survival and metabolism.
Overexpression of β-catenin leads to constitutive activation of cell proliferation 68 , and tumor cells downregulate the tumor suppressor GSK3β, which limits the activity of β-catenin by triggering its ubiquitin-mediated proteosomal degradation.
In these cells, curcumin upregulates GSK3β and causes loss of nuclear β-catenin. Loss of nuclear β-catenin results in a loss of its downstream target cyclin D1 NF-κB is a family of transcription factors that are involved in the immune response and inflammation.
Gene expression profiling studies suggest that the NF-κB pathway is a key regulator in triple-negative breast cancer TNBC , with activation of NF-κB signaling strongly implicated in the pathogenesis of specific TNBCs 72 — Cytoplasmic NF-κB is bound to a group of inhibitory proteins known as inhibitors of NF-κB IκB ; accumulation of non-phosphorylated IκB prohibits the translocation of NF-κB from cytoplasm to nucleus, resulting in inactivation of NF-κB and its downstream targets NF-κB promotes the transcription of numerous key regulators of cancer invasion and progression, including cytokines, chemokines, cell adhesion molecules and inducible pro-inflammatory enzymes In addition, NF-κB has been postulated to be a useful marker of the epithelial-mesenchymal transition EMT and invasiveness in breast cancer A number of previous studies suggest that curcumin inhibits NF-κB expression and therefore additional downstream signaling pathways, ultimately leading to the silencing of inflammatory cytokines, including chemokine C-X-C motif ligand CXCL 1 and CXCL2 19 ; and to alterations in the expression of MMP-9, urokinase plasminogen activator uPA , uPA receptor, intercellular adhesion molecule 1 and chemokine receptor 4 3 , 72 , In this manner, curcumin is likely to inhibit the growth and invasion of breast cancer, in part, by downregulating NF-κB signaling pathways.
Curcumin may modulate the expression of NF-κB target genes 76 , 77 , which include Bcl-2, ornithine decarboxylase ODC and c-myc, which are associated with apoptosis or cell survival For example, ODC is the rate-limiting enzyme in polyamine biosynthesis and curcumin has been demonstrated to suppress ODC activity and inhibit cell proliferation Accumulating evidence suggests that targeting NF-κB to inhibit cell growth and reverse EMT may be a novel therapeutic strategy in breast cancer.
Angiogenesis is the normal physiological mechanism by which novel blood vessels are formed from pre-existing blood vessels. It occurs during embryogenesis, menstruation and wound healing Angiogenesis in tumors is crucial for cancer progression.
Tumor cells procure nutrients for their uncontrolled growth through tumor angiogenesis Tumor cells constitutively produce pro-angiogenic factors, including vascular endothelial growth factor VEGF and basic fibroblast growth factor, which curcumin may inhibit in order to modulate tumor angiogenesis 81 , Curcumin inhibits angiogenesis and growth of breast cancer tumors implanted into nude mice.
These effects are associated with downregulated expression of a number of VEGF isomers, including VEGF-A, VEGF-C and VEGF receptor 2, in addition to decreased microvessel density These results are in agreement with other previous studies demonstrating that suppression of VEGF function inhibits breast tumor growth 83 , This suggests that curcumin acts as a potent anti-angiogenic agent in regulating OPN-induced tumor angiogenesis in breast cancer.
Curcumin causes blood thinning, which may decrease blood flow and increase the risk of ischemic stroke It may also inhibit the ability of chemotherapeutics to induce production of reactive oxygen species and block the c-Jun NH2-terminal kinase pathway.
In fact, curcumin may exert pro-oxidant effects, similar to numerous other anti-oxidants Curcumin significantly inhibits cyclophosphamide-induced regression of human breast cancer xenografts in mice 88 , Curcumin may also serve as an iron chelator to inhibit hypoxia inducible factor-α prolyl hydroxylase activity Therefore, further research is urgently required to establish whether patients with breast cancer undergoing chemotherapy should limit their intake of curcumin.
The available evidence suggests that curcumin, a polyphenolic compound derived from the dietary spice turmeric, is a non-toxic, highly promising natural anti-oxidant that exerts anticancer effects by targeting multiple molecules and pathways.
By affecting different targets, curcumin modulates numerous cancer hallmarks, including cell proliferation, cancer signaling pathways, transcription factors and tumor angiogenesis. Curcumin may have applications as a novel drug in the near future to control various diseases, particularly breast cancer.
The clinical use of curcumin is limited by its poor bioavailability; however, specific novel derivatives have been prepared that may improve patient responses.
Research is in progress on nanotechnology-based formulations and delivery systems to improve curcumin pharmacokinetics. Possibilities include encapsulating curcumin into polymeric or lipid micelles, or liposomes, and combining or conjugating curcumin to ligands or antibodies that may target cancer cell receptors or other epitopes.
Novel curcumin analogs and nanotechnology-based formulations may overcome the limitations of oral administration of curcumin. Supported by the Henan Science and Technology Innovation Team, Investigation on Plant Resources in Dabie Mountains and the study and utilization of active components of special plants grant no.
XS conceived and designed the article. MZ and ED read the literature and collated the appropriate information. XS and YL wrote the paper. Garcia-Aranda M and Redondo M: Protein kinase targets in breast cancer.
Int J Mol Sci. Sun YS, Zhao Z, Yang ZN, Xu F, Lu HJ, Zhu ZY, Shi W, Jiang J, Yao PP and Zhu HP: Risk factors and preventions of breast cancer. Int J Biol Sci. Ye JC and Formenti SC: Integration of radiation and immunotherapy in breast cancer - Treatment implications. Kasi PD, Tamilselvam R, Skalicka-Woźniak K, Nabavi SF, Daglia M, Bishayee A, Pazoki-Toroudi H and Nabavi SM: Molecular targets of curcumin for cancer therapy: An updated review.
Tumour Biol. Williams GH and Stoeber K: The cell cycle and cancer. J Pathol. Your dose of glyburide might need to be changed. Some medications are changed and broken down by the liver. Turmeric might change how quickly the liver breaks down these medications.
This could change the effects and side effects of these medications. Turmeric is an antioxidant. There is some concern that antioxidants might decrease the effects of some medications used for cancer.
If you are taking medications for cancer, check with your healthcare provider before taking turmeric. There is some concern that antioxidants might decrease the effects of medications used for cancer.
Turmeric might lower blood sugar levels. Taking turmeric along with diabetes medications might cause blood sugar to drop too low. Some medications are moved in and out of cells by pumps. Turmeric might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Turmeric might harm the liver. Some medications can also harm the liver. Taking turmeric along with a medication that can harm the liver might increase the risk of liver damage.
Turmeric might slow blood clotting. Taking turmeric along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Turmeric might increase how much norfloxacin the body absorbs. Taking turmeric while taking norfloxacin might increase the effects and side effects of norfloxacin.
Turmeric might change how much paclitaxel stays in the body. Taking turmeric while taking paclitaxel might change the effects and side effects of paclitaxel. Turmeric might increase how much sulfasalazine the body absorbs.
Taking turmeric while taking sulfasalazine might increase the effects and side effects of sulfasalazine. Turmeric might increase the amount of tacrolimus in the body. This can increase the side effects of tacrolimus and even damage the kidneys.
Turmeric might decrease how much talinolol the body absorbs. Taking turmeric while taking talinolol might decrease the effects of talinolol. Turmeric might decrease how much tamoxifen is in the body. Taking turmeric with tamoxifen might decrease the effects of tamoxifen.
Warfarin is used to slow blood clotting. Taking turmeric while taking warfarin might increase the effects of warfarin and increase the risk of bleeding and bruising. Are there any interactions with herbs and supplements? Information on this website is for informational use only and is not intended to replace professional medical advice, diagnosis, or treatment.
Always check with your doctor or other medical professional before making healthcare decisions including taking any medication and do not delay or disregard seeking medical advice or treatment based on any information displayed on this website. All rights reserved. Skip to content.
Turmeric Share. NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly Effective for … Hay fever. Taking turmeric by mouth seems to reduce hay fever symptoms such as sneezing, itching, runny nose, and congestion. A Curcumin inhibited the expression of CDC25 and CDC2, promoted the expression of P21, and inhibited the phosphorylation of Akt, mTOR and S6 after 12 h of treatment.
B Curcumin decreased the expression of the anti-apoptotic protein BCL2, increased the expression of the apoptotic protein BAX, and induced the cleavage of caspase 3 after 12 h of treatment.
The band intensity was analyzed by Image J software, and the expression of proteins is presented as normalized values divided by the control group. Curcumin was also found to promote apoptosis of breast cancer cells; thus, the expression of cell apoptotic proteins, such as BCL2, BAX and caspase 3, was also analyzed.
BCL2 is an anti-apoptotic protein, while BAX is a pro-apoptotic protein. Curcumin is a well-known natural compound, which has been shown to have pleotropic pharmacological properties, such as antifungal and antitumor properties 12 — In the present study, we investigated the antitumor activity of curcumin in breast cancer.
Curcumin was found to be a potent inhibitor on breast cancer cells in vitro , with an IC 50 at the micromolar level. To further investigate the molecular mechanism underlying the inhibitory effects of curcumin, T47D and MCF7 cells were selected, as they were found to be more sensitive to its actions.
The molecular mechanism underlying this action of curcumin was further explored. We found that curcumin decreased the expression of CDC25 and CDC2 and increased the expression of P The mTOR pathway, in addition to cancer, is also implicated in the pathogenesis of autoimmune 22 , 23 and infectious diseases 24 — Thus, we hypothesized that curcumin may also have therapeutic potential in autoimmune and infectious diseases, such as HIV infection.
In addition, curcumin may also promote the mitochondrial apoptotic pathway in breast cancer cells, further supporting the therapeutic value of curcumin in breast cancer. Although the preclinical data of curcumin in antitumor treatment are intriguing, several clinical studies with curcumin have yielded disappointing results.
Thus, several studies are underway aiming to develop curcumin analogues of higher potency, better bioavailability and longer half-life. For example, allylated monocarbonyl analogues and enone analogues of curcumin were found to promote mitotic arrest and apoptosis by reactive oxygen species-mediated stress 27 , Novel curcumin analogues exhibited high potency in castration-resistant prostate cancer 29 and nasopharyngeal carcinoma Interestingly, novel curcumin derivatives may exhibit high potency in triple-negative breast cancer cells 31 , 32 ; curcumin exhibited lower activity in these cancers cells in the present study, and suggested that optimization of curcumin structure may expand its therapeutic spectrum.
Thus, these results may provide a basis for further study of curcumin in the treatment of breast cancer. The authors would like to thank the Science and Technology Bureau of Shaoxing for awarding the grant. The present study was supported by a grant from the Science and Technology Bureau of Shaoxing grant no.
SH and HS were responsible for the conception and design of the study. SH, LM and LH collaborated in the development of methodology. SH, LM and HS acquired the data.
SH, LM, YX and HS wrote and revised the manuscript. DeSantis CE, Ma J, Sauer Goding A, Newman LA and Jemal A: Breast cancer statistics, , racial disparity in mortality by state.
CA Cancer J Clin. Karimi Z, Jessri M, Houshiar-Rad A, Mirzaei HR and Rashidkhani B: Dietary patterns and breast cancer risk among women. Public Health Nutr. Hart CD, Migliaccio I, Malorni L, Guarducci C, Biganzoli L and Di Leo A: Challenges in the management of advanced, ER-positive, HER2-negative breast cancer.
Nat Rev Clin Oncol. Arnedos M, Vicier C, Loi S, Lefebvre C, Michiels S, Bonnefoi H and Andre F: Precision medicine for metastatic breast cancer-limitations and solutions. Zhou QM, Wang XF, Liu XJ, Zhang H, Lu YY, Huang S and Su SB: Curcumin improves MMC-based chemotherapy by simultaneously sensitising cancer cells to MMC and reducing MMC-associated side-effects.
Eur J Cancer. Nagaraju GP, Aliya S, Zafar SF, Basha R, Diaz R and El-Rayes BF: The impact of curcumin on breast cancer. Integr Biol Camb. Quispe-Soto ET and Calaf GM: Effect of curcumin and paclitaxel on breast carcinogenesis.
Int J Oncol. Lee JY, Lee YM, Chang GC, Yu SL, Hsieh WY, Chen JJ, Chen HW and Yang PC: Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: The versatile adjuvant for gefitinib therapy.
PLoS One. Yoshida K, Toden S, Ravindranathan P, Han H and Goel A: Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression.
Gallardo M and Calaf GM: Curcumin inhibits invasive capabilities through epithelial mesenchymal transition in breast cancer cell lines. Gallardo M and Calaf GM: Curcumin and epithelial-mesenchymal transition in breast cancer cells transformed by low doses of radiation and estrogen.
Khalil OAK, de Faria Oliveir OMM, Vellosa JCR, Quadros AU, Dalposso LM, Karam TK, Mainardes RM and Khalil NM: Curcumin antifungal and antioxidant activities are increased in the presence of ascorbic acid. Food Chem.
View Article : Google Scholar. Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, Lo Russo L, Lillo DE A, Laino L and Lo Muzio L: Biological and therapeutic activities, and anticancer properties of curcumin.
Exp Ther Med. El-Houseini ME, El-Agoza IA, Sakr MM and El-Malky GM: NNovel protective role of curcumin and taurine combination against experimental hepatocarcinogenesis. Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J and Aggarwal BB: Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
Cancer Res. Oncol Rep. Cancer Treat Rev. Expert Rev Anticancer Ther. Steelman LS, Martelli AM, Cocco L, Libra M, Nicoletti F, Abrams SL and McCubrey JA: The therapeutic potential of mTOR inhibitors in breast cancer.
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Food for Breast Cancer. Turmeric Ideal body highly recommended for breast cancer. Turmeric is Muscle growth tips bright yellow spice Curcumib extensively in Indian cooking. Cancdr made from Cncer dried rhizome Curcujin stem of the Curcumin and Breast Cancer Curcuma longa. Biologically active components of turmeric include several curcuminoids including curcumin and other diarylheptanoids, as well as various turmerones and sesquiterpenoids. Turmeric and its components have been shown to have antioxidant, anti-inflammatory, antibacterial, antifungal, antiparasitic, anti-thrombotic, antiproliferative, anti-angiogenic, radioprotective, neuroprotective and cardioprotective effects. Curcumin has been shown in the laboratory to have profound and diverse effects on breast cancer development, proliferation and metastasis.
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🦠 TURMERIC STARVES CANCER CELLS NEWER STUDY FINDS 🦠 // Turmeric Annd MAYO CLINIC: I recently was Curcumin and Breast Cancer Cancr breast cancer, and I will Curccumin surgery followed by chemotherapy. A friend told me that turmeric has anti-cancer properties. I Ginseng nutritional properties taken turmeric Guarana Energy Pills in the past for osteoarthritis. Can you tell me Muscle growth tips Curcujin turmeric and if I can safely take it as a supplement along with conventional breast cancer treatment. ANSWER: Turmeric, a bright yellow spice powder made from the root of a plant in the ginger family, is grown in many Asian countries and other tropical areas. It's a major ingredient in curry powders common in many Indian and Asian dishes, and it is used as a coloring for foods, fabrics and cosmetics. The root can be dried and made into capsules, tablets, extracts, powders or teas.Curcumin and Breast Cancer -
In this study, we demonstrate that curcumin was able, in a dose- and time-dependent fashion, to inhibit camptothecin-mediated apoptosis in MCF-7 breast cancer cells Fig. This occurred at concentrations that have been documented in a Phase I chemoprevention trial in humans, where serum curcumin levels ranging from 0.
Serum levels in humans after an oral dose of curcumin peak rapidly in as little as 1—2 h, but they decline much more slowly over the next 12 h 25 , and in our studies, even a brief 3-h exposure to curcumin was sufficient to significantly inhibit apoptosis. Moreover, this inhibition was demonstrable in a concentration-dependent manner using the topoisomerase 1 inhibitor camptothecin, the alkylating agent mechlorethamine, and the anthracycline Adriamycin, not only in MCF-7 cells but also in MDA-MB and BT human breast cancer cells.
Such findings suggest that this activity is independent of p53 status because MCF-7 cells are p53 wild type, whereas MDA-MB and BT cells have mutant p Hormone receptor status would also appear to not be a significant influence because MCF-7 cells are estrogen receptor positive, whereas MDA-MB cells are receptor negative However, additional experiments, e.
To evaluate possible mechanisms responsible for this inhibition of apoptosis, we studied ROS generation and found that curcumin could, in a dose-dependent fashion, inhibit the camptothecin- and mechlorethamine-induced production of ROS Fig.
JNK activation with AP-1 activity Fig. These findings support the hypothesis that curcumin inhibits apoptosis by blocking ROS formation and JNK activation, both of which are important signals for cytochrome c release from mitochondria into the cytoplasm, which triggers caspase-mediated programmed cell death.
If confirmed, such a mechanism would allow the prediction that drugs that do not activate JNK should not be influenced by curcumin. Consistent with this assumption, methotrexate and 5-fluorouracil, two drugs used in the care of breast cancer patients, which function as antimetabolites and are not known to activate JNK, were able to induce apoptosis without any impact by curcumin data not shown.
It should be noted, however, that Bhaumik et al. This difference may be attributable to the experimental conditions because Bhaumik et al. used a concentration of 50 μ m curcumin and did not study its impact in the presence of a chemotherapeutic agent.
Alternatively, this may indicate that there is some cell type specificity to the impact of curcumin. The current studies also do not rule out a possible involvement of other pathways that are impacted upon by curcumin in blocking apoptosis. For example, activation of the transcription factor NF-κB is important in paclitaxel-induced apoptosis 58 , and because curcumin inhibits NF-κB 14, 15 , this may be another pathway involved in its antiapoptotic activity.
Additional ongoing studies using dominant negative mutant constructs that will selectively inactivate only one pathway at a time will hopefully prove instructive in elucidating the molecular basis for this function of curcumin.
Given the ability of curcumin to inhibit apoptosis in tissue culture, we sought to determine whether it could also do so in vivo , and we found that dietary supplementation significantly decreased cyclophosphamide-induced tumor growth delay Fig. Immunofluorescence studies indicated that this occurred in conjunction with decreased apoptosis and also with decreased JNK activation Fig.
This result was somewhat surprising in that, whereas serum curcumin concentrations in chemoprevention trials have been comparable with those used in our in vitro studies, these occurred at a daily curcumin dose of mg Even in populations where dietary curcumin intake is high, daily exposure is only on the order of mg 1, 2, 3, 4.
Therefore, it might seem unlikely that such diets would result in systemic curcumin levels approaching the conditions we used in vitro , especially since the oral bioavailability of curcumin is low because it is extensively metabolized by the liver.
Studies of tumor sections, however, revealed that those from the two curcumin-supplemented diet groups showed an immunofluorescence characteristic of curcumin, whereas the standard diet groups did not data not shown; Refs. This supports the possibility that, even after only short-term feeding, curcumin, or one of its metabolites, can be present in tumor tissue.
One possible explanation for the ability of dietary curcumin to inhibit apoptosis at low levels of exposure in vivo is that this may represent a difference in the absorption and metabolism of curcumin between humans and animals.
A recent study comparing human and rat hepatocytes, however, found that the major metabolites in both were hexahydrocurcumin and hexahydrocurcuminol Alternatively, although curcumin metabolites have been shown to be less able to inhibit phorbol ester-induced prostaglandin E 2 production in human colonic epithelial cells than the parental compound 59 , they may be more active than curcumin in their ability to inhibit ROS formation, JNK activity, and cytochrome c release.
Finally, it is possible that some of the antiapoptotic effect of curcumin in vivo does not require it to be present at the site of the tumor. Cyclophosphamide is a prodrug activated by cytochrome Ps in the liver 45 , and curcumin inhibits several P isoenzymes The higher concentrations of curcumin one would expect to find in the liver after a meal containing this agent may be sufficient to inhibit conversion of cyclophosphamide to its active metabolites, thereby limiting its antitumor efficacy.
Because curcumin has antiangiogenic properties and may have therapeutic potential in human prostate cancer 24 , our findings also suggest care in its application to patients with other malignancies receiving concurrent chemotherapy until this activity of curcumin can be further investigated.
It is possible, therefore, that the effects of curcumin might be amplified in patients with colon cancer receiving chemotherapy unless, as noted above, it has some cell type specificity, or its antiapoptotic effects are mediated through hepatic cytochrome P Finally, these findings strongly support additional research to determine whether breast cancer, and possibly other cancer patients undergoing chemotherapy, should limit dietary supplementation of curcumin, which is widely available over the counter as turmeric extracts, and possibly even avoid curcumin-containing foods altogether.
Curcumin inhibits camptothecin-induced apoptosis in MCF-7 cells. A , MCF-7 breast carcinoma cells were exposed for 12 h to either vehicle Lane 3 , 10 μ m curcumin Lane 4 , 10 μ m camptothecin Lane 5 , or both camptothecin and curcumin Lane 6 , and compared with mock-treated cells Lane 2.
Apoptosis-associated DNA fragmentation was evaluated by agarose gel electrophoresis with λ digested with Hin dIII Lane 1 and a bp ladder Lane 7 as standards.
B , after MCF-7 cells were treated with vehicle, curcumin, camptothecin, or curcumin and camptothecin, apoptosis was evaluated using the Cell Death Detection ELISA PLUS kit. Results are the mean and SE from four experiments expressed as the fold increase in apoptosis compared with the vehicle control, arbitrarily set at 1.
C , caspase 3 activity assays were performed on MCF-7 cells using the substrate acetyl-aspartyl-glutamyl-valyl-aspartate.
Results are the mean ± SE from three experiments, expressed as the ratio of absorbance of each sample to that of the vehicle control, arbitrarily set at 1. D , time dependence was studied by treating MCF-7 cells with Curcumin was either preincubated for 3 h and then present throughout camptothecin treatment for a total of 15 h, added at the same time as camptothecin, or at 3-h intervals thereafter.
The mean percentage inhibition ± SE is shown from four experiments. Curcumin inhibits generation of ROS. MCF-7 A and BT B cells were either mock treated, vehicle treated, or exposed to curcumin at 1, 5, and 10 μ m.
In parallel, they were exposed to either 10 μ m camptothecin or μ m mechlorethamine, with or without curcumin, for 12 h. The mean ± SE is shown from three experiments, each performed in duplicate.
Curcumin inhibits JNK activation. MCF-7 A and BT B cells were treated as described in the legend to Fig. The mean ± SE is shown from two experiments, each performed in duplicate, with results expressed in relation to vehicle-only controls, which were arbitrarily set at 1.
Curcumin inhibits release of cytochrome c into the cytosol. MCF-7 cells were treated with vehicle and camptothecin A or mechlorethamine B either alone or in the presence of curcumin. The content of cytochrome c in the cytosol was evaluated by Western blotting, and equal loading was confirmed by reprobing each blot for heat shock cognate protein Densitometry of the autoradiographs was performed for cytochrome c levels, corrected for loading, and the data are shown below each panel in relation to the chemotherapy agent alone, which was arbitrarily set at 1.
BT cells were similarly treated in C and D , respectively, and each panel is a representative result from one of two experiments.
V , vehicle; Cam , camptothecin; Mech , mechlorethamine. Dietary curcumin blunts cyclophosphamide-mediated tumor growth inhibition. Nude mice bearing BTbased xenografts were randomized on day 0 to receive either standard or curcumin-supplemented diets and on day 1 were treated with a single i.
Tumor weights were followed for a total of 3 days, calculated using the tumor dimensions, and plotted as the ratio of the tumor weight to that on day 0, which is arbitrarily set at 1.
Sixteen mice were included in each of these treatment groups, whereas two additional groups were treated with either a standard diet and vehicle or the curcumin-supplemented diet and vehicle.
These results are described in the text. Dietary curcumin inhibits apoptosis and JNK activation in vivo. One day after treatment with cyclophosphamide, BTbased tumor xenografts were excised, sectioned, and prepared for immunofluorescence.
Apoptosis induced by cyclophosphamide is shown in the standard diet group A and in the curcumin-supplemented diet group B as red areas containing ssDNA.
Phospho-JNK staining is shown in C and D for these two groups, respectively, with red areas indicating presence of phosphorylated, activated JNK. Control slides from vehicle-treated standard diet and curcumin diet groups were prepared as well.
The density of immunofluorescence staining discussed in the text is the mean from five separate fields on two duplicate slides. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.
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Skip Nav Destination Close navigation menu Article navigation. Volume 62, Issue Previous Article Next Article. MATERIALS AND METHODS. Article Navigation. Tumor Biology July 01 Dietary Curcumin Inhibits Chemotherapy-induced Apoptosis in Models of Human Breast Cancer 1 Sivagurunathan Somasundaram ; Sivagurunathan Somasundaram.
The Lineberger Comprehensive Cancer Center [S. This Site. Google Scholar. Natalie A. Edmund ; Natalie A. Dominic T. Moore ; Dominic T. George W. Small ; George W. Yue Y. Shi ; Yue Y. Robert Z.
Orlowski Robert Z. Received: February 15 Accepted: April 25 Online ISSN: Cancer Res 62 13 : — Article history Received:. Cite Icon Cite. toolbar search Search Dropdown Menu.
toolbar search search input Search input auto suggest. View large Download slide. Curcumin concentration. Breast cancer cell line. Camptothecin 1 μ m 9. a All results are the mean and SE from four experiments. People commonly use turmeric for osteoarthritis. It is also used for hay fever, depression, high cholesterol, a type of liver disease, and itching, but there is no good scientific evidence to support most of these uses.
There is also no good evidence to support using turmeric for COVID When applied to the skin : Turmeric is likely safe. It is possibly safe when turmeric is applied inside the mouth as a mouthwash.
Pregnancy : Turmeric is commonly used in small amounts as a spice in foods. It might cause a menstrual period or stimulate the uterus, putting the pregnancy at risk.
Do not take medicinal amounts of turmeric if you are pregnant. Breast-feeding : Turmeric is commonly used in small amounts as a spice in foods.
Stay on the safe side and avoid use. Gallbladder problems : Turmeric can make gallbladder problems worse. Do not use turmeric if you have gallstones or a bile duct obstruction.
Bleeding problems : Taking turmeric might slow blood clotting. This might increase the risk of bruising and bleeding in people with bleeding disorders.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids : Turmeric contains a chemical called curcumin, which might act like the hormone estrogen.
In theory, this might have effects on hormone-sensitive conditions. Until more is known, use cautiously if you have a condition that might be made worse by exposure to hormones. Infertility : Turmeric might lower testosterone levels and decrease sperm movement.
This might reduce fertility. Turmeric should be used cautiously by people trying to have a baby. Liver disease : There is some concern that turmeric can damage the liver, especially in people who have swelling inflammation of the liver hepatitis or reduced or blocked flow of bile from the liver cholestasis.
Surgery : Turmeric might slow blood clotting. It might cause extra bleeding during and after surgery. Stop using turmeric at least 2 weeks before a scheduled surgery. Turmeric might increase how much amlodipine the body absorbs.
Taking turmeric while taking amlodipine might increase the effects and side effects of amlodipine. Turmeric might increase how much docetaxel the body absorbs. Taking turmeric while taking docetaxel might increase the effects and side effects of docetaxel. Large amounts of turmeric might interfere with the effects of estrogen.
Taking turmeric along with estrogen might decrease the effects of estrogens. Some estrogen pills include conjugated equine estrogens Premarin , ethinyl estradiol, estradiol, and others. Turmeric contains curcumin. Curcumin might lower blood sugar. Glyburide is also used to lower blood sugar.
Taking curcumin or turmeric along with glyburide might cause your blood sugar to go too low. Monitor your blood sugar closely.
Your dose of glyburide might need to be changed. Some medications are changed and broken down by the liver. Turmeric might change how quickly the liver breaks down these medications.
This could change the effects and side effects of these medications. Turmeric is an antioxidant. On the other hand, turmeric and curcumin supplements, which concentrate the phytoestrogens in turmeric, have the potential for adverse effects, depending on the formulation.
In any case, they should not be taken during tamoxifen treatment since curcumin has been shown to interfere with the metabolism of tamoxifen and reduce it's treatment efficacy see our article on tamoxifen and turmeric or curcumin supplements.
Turmeric should be purchased organic. Curcumin has been shown to have a cytotoxic impact on microbes such as the malaria parasite Plasmodium falciparum. One study also showed that long-term use of low-dose curcumin supplementation suppressed immunity against some other microbes i.
Consuming black pepper along with turmeric may increase the spice's anti-breast cancer action by enhancing breast cancer cell including breast cancer stem cell sensitivity to curcumin. The information above, which is updated continually as new research becomes available, has been developed based solely on the results of academic studies.
Clicking on any of the underlined terms will take you to its tag or webpage, which contain more extensive information. Below are links to 20 recent studies concerning this food and its components.
For a more complete list, including less recent studies, please click on turmeric. Fawzy RM, Abdel-Aziz AA, Bassiouny K, Fayed AM. Phytocompounds-based therapeutic approach: Investigating curcumin and green tea extracts on MCF-7 breast cancer cell line.
Journal of Genetic Engineering and Biotechnology. Elsevier BV; ; Zhang H, Li Y. Targeting the breast tumor microenvironment by plant-derived products and their nanoformulations.
Journal of Drug Delivery Science and Technology. Nguyen NT, Nguyen VT, Vu TT, Le Nguyen TV, Nguyen TTT, Huynh PD, et al.
Efficient and controllable co-delivery of paclitaxel and curcumin from fucoidan-pluronic F nanogel for synergistic breast cancer treatment. Macromolecular Research. Springer Science and Business Media LLC; ; Focaccetti C, Palumbo C, Benvenuto M, Carrano R, Melaiu O, Nardozi D, et al.
The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival. International Journal of Molecular Sciences. MDPI AG; ; Sirigiripeta S, Dokala A, Anupalli R. Cytology and Genetics. Allerton Press; ; Jang B, Shin M, Han D, Sung J.
Jalilian E, Abolhasani-Zadeh F, Afgar A, Samoudi A, Zeinalynezhad H, Langroudi L. Neutralizing tumor-related inflammation and reprogramming of cancer-associated fibroblasts by Curcumin in breast cancer therapy.
This cancer Curcumin and Breast Cancer summary provides Mind-body connection in eating overview adn the use of ajd as a Cuurcumin for people with cancer. Curcumin is a member Brreast the diarylheptanoid Curcumin and Breast Cancer of natural products curcuminoids derived Anf the rhizome of Curcuma longa L. The other major curcuminoids present in turmeric are demethoxycurcumin, bisdemethoxycurcumin, and cyclocurcumin; together, they are termed the curcuminoid complex. The turmeric plant and preparations derived from it have a long history of therapeutic application in traditional Asian medicine. The crude and often dried plant material is widely consumed as a food additive, as part of curry spices, which typically contain numerous other ingredients.
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