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Creatine: Why You Should Consider Taking ItCreatine supplement information -
The lowest range of CK values have been reported during early pregnancy 20 weeks or less , equating to about half the concentration found at peak levels teenage girls [ , ]. Maternal creatine supplementation during pregnancy in pre-clinical animal studies have demonstrated a protective effect against fetal death and organ damage associated with intrapartum hypoxia [ , ].
Reduced creatine levels in late pregnancy have also been associated with low fetal growth [ ]. There is additional data that metabolic demand from the placenta during gestation further lowers the creatine pool of the mother [ ], which may be associated with low birth weight and pre-term birth.
Creatine supplementation during pregnancy has been shown to enhance neuronal cell uptake of creatine and support mitochondrial integrity in animal offspring, thereby reducing brain injury induced by intrapartum asphyxia [ , ].
Although there are no human studies evaluating the effects of creatine supplementation during pregnancy, creatine could provide a safe, low-cost nutritional interventional for reducing intra- and post-partum complications associated with cellular energy depletion [ ].
This may be more important if the female is vegetarian, or unable to consume meat due to nausea or taste preferences i. meat contains about 0. Females have been reported to have lower levels of creatine in the brain frontal lobe [ ]. Increasing creatine concentrations in the brain as a result of supplementation, particularly in females, may support the reported benefits of reducing symptoms of depression [ , ] and ameliorating the effects of traumatic brain injury [ 12 , 22 ].
Depression is about 2 times higher among females throughout the reproductive years [ ] and accelerates around pubertal hormonal changes [ ].
Altered brain bioenergetics and mitochondrial dysfunction have been linked with depression, particularly as it relates to CK, ATP, and inorganic phosphate P i. Creatine supplementation has been shown to significantly augment cerebral PCr and P i [ ], particularly in females.
There is a small body of research that has investigated the effects of creatine supplementation in younger females. For example, Vandenberghe et al. Hamilton et al. Furthermore, in college-aged females 20 yrs , creatine supplementation 0.
In contrast, not all data show improved performance in females [ 89 , , ]. Additionally, Smith-Ryan et al. It is important to evaluate the benefit to risk ratio; as noted elsewhere in this document, there are minimal risks associated with creatine supplementation, particularly when it is evaluated against the potential benefits in females.
Accumulating research over the past decade in postmenopausal females demonstrates that creatine supplementation during a resistance training program can improve muscle mass, upper- and lower-body strength, and tasks of functionality s chair stand, lying prone-to-stand test, arm curl test for detailed review see Candow et al.
Creatine supplementation appears to be a viable option for post-menopausal females to improve muscle quality and performance. In addition to its beneficial effects on aging muscle, creatine supplementation may also have favorable effects on bone in postmenopausal females, if combined with resistance training.
For example, postmenopausal females who supplemented daily with 0. However, even without the stimulus of resistance training, there is some evidence that creatine supplementation can still be beneficial. In summary, there is accumulating evidence that creatine supplementation has the potential to be a multifactorial therapeutic intervention across the lifespan in females, with little to no side effects.
Creatine monohydrate powder has been the most extensively studied and commonly used form of creatine in dietary supplements since the early s [ 2 , ]. Creatine monohydrate was used in early studies to assess bioavailability, determine proper dosages, and assess the impact of oral ingestion of creatine on blood creatine and intramuscular creatine stores [ 35 , 60 , ].
These studies indicated that orally ingested creatine monohydrate e. Short-term loading with creatine monohydrate e. Creatine monohydrate supplementation during training e. Despite the known efficacy, safety, and low cost of creatine monohydrate; a number of different forms of creatine have been marketed as more effective with fewer anecdotally reported adverse effects [ ].
These marketing efforts have fueled speculation that creatine monohydrate is not the most effective or safest form of creatine to consume. This notion is clearly refuted by understanding the well-known physio-chemical properties of creatine monohydrate, as well as current creatine supplementation literature.
A number of different forms of creatine e. have been marketed as more effective sources of creatine than creatine monohydrate [ ]. However, there are no peer-reviewed published papers showing that the ingestion of equal amounts of creatine salts [ , , , ] or other forms of creatine like effervescent creatine [ ], creatine ethyl ester [ 43 , , ], buffered creatine [ 41 ], creatine nitrate [ , ], creatine dipeptides, or the micro amounts of creatine contained in creatine serum [ ] and beverages e.
Creatine monohydrate crystallizes from water as monoclinic prisms that hold one molecule of water of crystallization per molecule of creatine [ ]. Creatine is considered a weak base pKb Creatine can also serve as a complexing agent with other compounds via ionic binding.
Creatine monohydrate powder contains the highest percentage of creatine Creatine monohydrate manufactured in Germany involves adding acetic acid to sodium sarconsinate, heating, adding cyanamide, cooling to promote crystallization, separation and filtration, and drying has been reported to produce Meanwhile, other sources of creatine monohydrate that have different starting materials e.
While the effects of ingesting these compounds on health are unknown, contamination with dihydrotriazine has been suggested to be of greatest concern since it is structurally related to carcinogenic compounds [ ]. For this reason, German sourced creatine monohydrate has been primarily used in research to establish safety and efficacy and is therefore the recommended source of creatine monohydrate to use in dietary supplements [ 2 , ].
Creatine monohydrate powder is very stable showing no signs of degradation into creatinine over years, even at elevated storage temperatures [ ].
However, creatine is not stable in solution due to intramolecular cyclization that converts creatine to creatinine especially at higher temperatures and lower pH [ , , , ]. The degradation of creatine can be reduced or halted by lowering the pH under 2. Moreover, since creatine is an ampholytic amino acid, it is not very soluble in water e.
Mixing creatine in higher temperature solution increase solubility, which is the reason why initial studies administered creatine in hot tea [ 35 , 60 , , , , ] but the solubility has no influence on tissue uptake [ ].
The lack of solubility and stability of creatine in solution is the reason that creatine is primarily marketed in powder form and efforts to develop stable beverages containing physiologically effective doses of creatine e.
In summary, while some forms of creatine may be more soluble than creatine monohydrate when mixed in fluid, evidence-based research clearly shows creatine monohydrate to be the optimal choice.
Creatine supplementation appears to be generally safe and potentially beneficial for children and adolescents. Smaller, daily dosages of creatine supplementation g or 0. Creatine supplementation and resistance training produces the vast majority of musculoskeletal and performance benefits in older adults.
Creatine supplementation alone can provide some muscle and performance benefits for older adults. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism.
Article CAS PubMed Google Scholar. Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, Candow DG, Kleiner SM, Almada AL, Lopez HL. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine.
Sports Nutr. Article CAS Google Scholar. Bongiovanni T, Genovesi F, Nemmer M, Carling C, Alberti G, Howatson G. Nutritional interventions for reducing the signs and symptoms of exercise-induced muscle damage and accelerate recovery in athletes: current knowledge, practical application and future perspectives.
Article PubMed Google Scholar. de Guingand DL, Palmer KR, Snow RJ, Davies-Tuck ML, Ellery SJ. Risk of Adverse Outcomes in Females Taking Oral Creatine Monohydrate: A Systematic Review and Meta-Analysis.
Kaviani M, Shaw K, Chilibeck PD. Benefits of Creatine Supplementation for Vegetarians Compared to Omnivorous Athletes: A Systematic Review.
Vega J, Huidobro EJP. Effects of creatine supplementation on renal function. Dolan E, Gualano B, Rawson ES. Beyond muscle: the effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury.
Dolan E, Artioli GG, Pereira RMR, Gualano B. Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation? Candow DG, Forbes SC, Chilibeck PD, Cornish SM, Antonio J, Kreider RB. Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation.
Variables Influencing the Effectiveness of Creatine Supplementation as a Therapeutic Intervention for Sarcopenia. Article PubMed PubMed Central CAS Google Scholar. Marques EP, Wyse ATS. Creatine as a Neuroprotector: an Actor that Can Play Many Parts.
Neurotox Res. Balestrino M, Adriano E. Beyond sports: Efficacy and safety of creatine supplementation in pathological or paraphysiological conditions of brain and muscle. Sumien N, Shetty RA, Gonzales EB. Creatine, Creatine Kinase, and Aging. Fairman CM, Kendall KL, Hart NH, Taaffe DR, Galvao DA, Newton RU.
The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer. Valenzuela PL, Morales JS, Emanuele E, Pareja-Galeano H, Lucia A. Supplements with purported effects on muscle mass and strength.
Jagim AR, Stecker RA, Harty PS, Erickson JL, Kerksick CM. Safety of Creatine Supplementation in Active Adolescents and Youth: A Brief Review. Davani-Davari D, Karimzadeh I, Sagheb MM, Khalili H. The Renal Safety of L-Carnitine, L-Arginine, and Glutamine in Athletes and Bodybuilders.
Robinson SM, Reginster JY, Rizzoli R, Shaw SC, Kanis JA, Bautmans I, Bischoff-Ferrari H, Bruyere O, Cesari M, Dawson-Hughes B, Fielding RA, Kaufman JM, Landi F, Malafarina V, Rolland Y, van Loon LJ, Vellas B, Visser M, Cooper C.
ESCEO working group Does nutrition play a role in the prevention and management of sarcopenia? Chilibeck PD, Kaviani M, Candow DG, Zello GA. Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis.
Open Access J. Sports Med. Article PubMed PubMed Central Google Scholar. Butts J, Jacobs B, Silvis M. Creatine Use in Sports. Sports Health. Farshidfar F, Pinder MA, Myrie SB. Creatine Supplementation and Skeletal Muscle Metabolism for Building Muscle Mass- Review of the Potential Mechanisms of Action.
Protein Pept. Ainsley Dean PJ, Arikan G, Opitz B, Sterr A. Potential for use of creatine supplementation following mild traumatic brain injury. eCollection Jun. Andres RH, Wallimann T, Widmer HR.
Creatine supplementation improves neural progenitor cell survival in Huntington's disease. Brain Circ. Andres S, Ziegenhagen R, Trefflich I, Pevny S, Schultrich K, Braun H, Schanzer W, Hirsch-Ernst KI, Schafer B, Lampen A.
Creatine and creatine forms intended for sports nutrition. Food Res. Lanhers C, Pereira B, Naughton G, Trousselard M, Lesage FX, Dutheil F. Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis.
Pinto CL, Botelho PB, Pimentel GD, Campos-Ferraz PL, Mota JF. Creatine supplementation and glycemic control: a systematic review. Amino Acids. Gualano B, Rawson ES, Candow DG, Chilibeck PD.
Creatine supplementation in the aging population: effects on skeletal muscle, bone and brain. Twycross-Lewis R, Kilduff LP, Wang G, Pitsiladis YP.
The effects of creatine supplementation on thermoregulation and physical cognitive performance: a review and future prospects.
Ellery SJ, Walker DW, Dickinson H. Creatine for women: a review of the relationship between creatine and the reproductive cycle and female-specific benefits of creatine therapy.
Brosnan ME, Brosnan JT. The role of dietary creatine. Deminice R, de Castro GS, Brosnan ME, Brosnan JT. Creatine supplementation as a possible new therapeutic approach for fatty liver disease: early findings.
Balestrino M, Sarocchi M, Adriano E, Spallarossa P. Potential of creatine or phosphocreatine supplementation in cerebrovascular disease and in ischemic heart disease. Google Scholar. Freire Royes LF, Cassol G. The Effects of Creatine Supplementation and Physical Exercise on Traumatic Brain Injury.
Mini Rev. Riesberg LA, Weed SA, McDonald TL, Eckerson JM, Drescher KM. Beyond muscles: The untapped potential of creatine. Article CAS PubMed PubMed Central Google Scholar.
Hultman, E. Muscle creatine loading in men. Hall M, Trojian TH. Creatine supplementation. Rosene JM, Matthews TD, Mcbride KJ, Galla A, Haun M, Mcdonald K, Gagne N, Lea J, Kasen J, Farias C. The effects of creatine supplementation on thermoregulation and isokinetic muscular performance following acute 3-day supplementation.
CAS PubMed Google Scholar. Ziegenfuss T, Lowery LM, Lemon P. Acute fluid volume changes in men during three days of creatine supplementation. Journal of Exercise Physiology Online. Francaux M, Poortmans JR.
Side effects of creatine supplementation in athletes. Sports Physiol. Andre TL, Gann JJ, McKinley-Barnard SK, Willoughby DS. Effects of five weeks of resistance training and relatively-dosed creatine monohydrate supplementation on body composition and muscle strength and whole-body creatine metabolism in resistance-trained males.
Int J Kinesiol Sports Sci. Jagim AR, Oliver JM, Sanchez A, Galvan E, Fluckey J, Riechman S, Greenwood M, Kelly K, Meininger C, Rasmussen C, Kreider RB. A buffered form of creatine does not promote greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrate.
Rawson ES, Stec MJ, Frederickson SJ, Miles MP. Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain. Spillane M, Schoch R, Cooke M, Harvey T, Greenwood M, Kreider R, Willoughby DS.
The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. Powers ME, Arnold BL, Weltman AL, Perrin DH, Mistry D, Kahler DM, Kraemer W, Volek J. Creatine Supplementation Increases Total Body Water Without Altering Fluid Distribution.
Athl Train. PubMed PubMed Central Google Scholar. Ribeiro AS, Avelar A, Kassiano W, Nunes JP, Schoenfeld BJ, Aguiar AF, Trindade MCC, Silva AM, Sardinha LB, Cyrino ES. Creatine Supplementation Does Not Influence the Ratio Between Intracellular Water and Skeletal Muscle Mass in Resistance-Trained Men.
Sport Nutr. Safdar A, Yardley NJ, Snow R, Melov S, Tarnopolsky MA. Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation. Kersey RD, Elliot DL, Goldberg L, Kanayama G, Leone JE, Pavlovich M, Pope HG.
National Athletic Trainers' Association National Athletic Trainers' Association position statement: anabolic-androgenic steroids.
Davey RA, Grossmann M. Androgen Receptor Structure, Function and Biology: From Bench to Bedside. Rawson ES, Clarkson PM, Price TB, Miles MP. Differential response of muscle phosphocreatine to creatine supplementation in young and old subjects.
Acta Physiol. Persky AM, Rawson ES. Safety of creatine supplementation. Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Poortmans JR, Auquier H, Renaut V, Durussel A, Saugy M, Brisson GR. Effect of short-term creatine supplementation on renal responses in men.
Greenhaff P. Rawson ES. The safety and efficacy of creatine monohydrate supplementation: What we have learned from the past 25 years of research. Gatorade Sports Science Exchange. Poortmans JR, Francaux M. de Souza E Silva A; Pertille, A. Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis.
Gualano B, de Salles Painelli V, Roschel H, Lugaresi R, Dorea E, Artioli GG, Lima FR, da Silva ME, Cunha MR, Seguro AC, Shimizu MH, Otaduy MC, Sapienza MT, da Costa Leite C, Bonfa E, Lancha Junior AH. Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial.
Gualano B, Roschel H, Lancha AH, Brightbill CE, Rawson ES. In sickness and in health: the widespread application of creatine supplementation.
Rawson ES, Clarkson PM, Tarnopolsky MA. Perspectives on Exertional Rhabdomyolysis. Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. van der Merwe J, Brooks NE, Myburgh KH. Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players.
Sport Med. Ustuner ET. Cause of androgenic alopecia: crux of the matter. Glob Open. Bartsch G, Rittmaster RS, Klocker H. Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia.
World J. Trueb RM. Molecular mechanisms of androgenetic alopecia. Vatani DS, Faraji H, Soori R, Mogharnasi M. The effects of creatine supplementation on performance and hormonal response in amateur swimmers. Science and Sports.
Article Google Scholar. Arazi H, Rahmaninia F, Hosseini K, Asadi A. Effects of short term creatine supplementation and resistance exercises on resting hormonal and cardiovascular responses.
Cook CJ, Crewther BT, Kilduff LP, Drawer S, Gaviglio CM. Skill execution and sleep deprivation: effects of acute caffeine or creatine supplementation - a randomized placebo-controlled trial.
Cooke MB, Brabham B, Buford TW, Shelmadine BD, McPheeters M, Hudson GM, Stathis C, Greenwood M, Kreider R, Willoughby DS. Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged males.
Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J. Volek JS, Ratamess NA, Rubin MR, Gomez AL, French DN, McGuigan MM, Scheett TP, Sharman MJ, Hakkinen K, Kraemer WJ. The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching.
Rahimi R, Faraji H, Vatani DS, Qaderi M. Creatine supplementation alters the hormonal response to resistance exercise. Dalbo VJ, Roberts MD, Stout JR, Kerksick CM. Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration.
Adverse effects of creatine supplementation: fact or fiction? Terjung RL, Clarkson P, Eichner ER, Greenhaff PL, Hespel PJ, Israel RG, Kraemer WJ, Meyer RA, Spriet LL, Tarnopolsky MA, Wagenmakers AJ, Williams MH.
American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation. Sci Sports Exerc. Kraemer WJ, Volek JS. Its role in human performance. CAS Google Scholar. Deminice R, Rosa FT, Pfrimer K, Ferrioli E, Jordao AA, Freitas E.
Creatine Supplementation Increases Total Body Water in Soccer Players: a Deuterium Oxide Dilution Study. Greenwood M, Farris J, Kreider R, Greenwood L, Byars A. Creatine supplementation patterns and perceived effects in select division I collegiate athletes.
Greenwood M, Kreider RB, Melton C, Rasmussen C, Lancaster S, Cantler E, Milnor P, Almada A. Creatine supplementation during college football training does not increase the incidence of cramping or injury. Chang CT, Wu CH, Yang CW, Huang JY, Wu MS.
Creatine monohydrate treatment alleviates muscle cramps associated with haemodialysis. Unnithan VB, Veehof SH, Vella CA, Kern M. Is there a physiologic basis for creatine use in children and adolescents? Strength Cond Res.
Hayashi AP, Solis MY, Sapienza MT, Otaduy MC, de Sa Pinto AL, Silva CA, Sallum AM, Pereira RM, Gualano B. Efficacy and safety of creatine supplementation in childhood-onset systemic lupus erythematosus: a randomized, double-blind, placebo-controlled, crossover trial.
Tarnopolsky MA, Mahoney DJ, Vajsar J, Rodriguez C, Doherty TJ, Roy BD, Biggar D. Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy. Sakellaris G, Kotsiou M, Tamiolaki M, Kalostos G, Tsapaki E, Spanaki M, Spilioti M, Charissis G, Evangeliou A. Prevention of complications related to traumatic brain injury in children and adolescents with creatine administration: an open label randomized pilot study.
Kayton S, Cullen RW, Memken JA, Rutter R. Supplementation and ergogenic aid use by competitive male and female high school athletes. Diehl K, Thiel A, Zipfel S, Mayer J, Schnell A, Schneider S. Elite adolescent athletes' use of dietary supplements: characteristics, opinions, and sources of supply and information.
Gotshalk LA, Kraemer WJ, Mendonca MA, Vingren JL, Kenny AM, Spiering BA, Hatfield DL, Fragala MS, Volek JS. Creatine supplementation improves muscular performance in older women. Gotshalk LA, Volek JS, Staron RS, Denegar CR, Hagerman FC, Kraemer WJ.
Creatine supplementation improves muscular performance in older men. Sports Exerc. Silva AJ, Machado Reis V, Guidetti L, Bessone Alves F, Mota P, Freitas J, Baldari C. Effect of creatine on swimming velocity, body composition and hydrodynamic variables. Forbes SC, Sletten N, Durrer C, Myette-Cote E, Candow D, Little JP.
Creatine Monohydrate Supplementation Does Not Augment Fitness, Performance, or Body Composition Adaptations in Response to Four Weeks of High-Intensity Interval Training in Young Females. Antonio J, Ciccone V.
The effects of pre versus post workout supplementation of creatine monohydrate on body composition and strength. Becque MD, Lochmann JD, Melrose DR. Effects of oral creatine supplementation on muscular strength and body composition.
Chilibeck PD, Magnus C, Anderson M. Effect of in-season creatine supplementation on body composition and performance in rugby union football players. Volek JS, Duncan ND, Mazzetti SA, Staron RS, Putukian M, Gomez AL, Pearson DR, Fink WJ, Kraemer WJ. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training.
Chrusch MJ, Chilibeck PD, Chad KE, Davison KS, Burke DG. Creatine supplementation combined with resistance training in older men. Gualano B, Macedo AR, Alves CR, Roschel H, Benatti FB, Takayama L, de Sa Pinto AL, Lima FR, Pereira RM. Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial.
Candow DG, Vogt E, Johannsmeyer S, Forbes SC, Farthing JP. Strategic creatine supplementation and resistance training in healthy older adults. Bourgeois JM, Nagel K, Pearce E, Wright M, Barr RD, Tarnopolsky MA. Creatine monohydrate attenuates body fat accumulation in children with acute lymphoblastic leukemia during maintenance chemotherapy.
Blood Cancer. Lobo DM, Tritto AC, da Silva LR, de Oliveira PB, Benatti FB, Roschel H, Niess B, Gualano B, Pereira RM. Effects of long-term low-dose dietary creatine supplementation in older women.
Sales LP, Pinto AJ, Rodrigues SF, Alvarenga JC, Goncalves N, Sampaio-Barros MM, Benatti FB, Gualano B, Rodrigues Pereira RM. A Biol. Forbes S, Candow D, Krentz J, Roberts M, Young K. Journal of Functional Morphology and Kinesiology. Article PubMed Central Google Scholar. Hunter A. Monographs on biochemistry: creatine and creatinine.
London: Longmans, Green and Co; Myers V. The creatine content of muscle under normal conditions. Its relation to the urinary creatinine. J Biol Chem. Casey A, Constantin-Teodosiu D, Howell S, Hultman E, Greenhaff PL. Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans.
Greenhaff PL, Bodin K, Soderlund K, Hultman E. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Ostojic SM, Ahmetovic Z. Gastrointestinal distress after creatine supplementation in athletes: are side effects dose dependent?
Gualano B, Artioli GG, Poortmans JR, Lancha Junior AH. Exploring the therapeutic role of creatine supplementation.
Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M.
Writing Group for the European Working Group on Sarcopenia in Older People 2 EWGSOP2 , and the Extended Group for EWGSOP2 Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. Mcleod JC, Stokes T, Phillips SM. Resistance Exercise Training as a Primary Countermeasure to Age-Related Chronic Disease.
Stout JR, Sue Graves B, Cramer JT, Goldstein ER, Costa PB, Smith AE, Walter AA. Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women 64 - 86 years. Health Aging.
Canete S, San Juan AF, Perez M, Gomez-Gallego F, Lopez-Mojares LM, Earnest CP, Fleck SJ, Lucia A. Does creatine supplementation improve functional capacity in elderly women? PubMed Google Scholar. Baker TP, Candow DG, Farthing JP.
Effect of Preexercise Creatine Ingestion on Muscle Performance in Healthy Aging Males. Chami J, Candow DG. Effect of Creatine Supplementation Dosing Strategies on Aging Muscle Performance. Bermon S, Venembre P, Sachet C, Valour S, Dolisi C. Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults.
Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Rawson ES, Clarkson PM. Acute creatine supplementation in older men.
Wiroth JB, Bermon S, Andrei S, Dalloz E, Hebuterne X, Dolisi C. Effects of oral creatine supplementation on maximal pedalling performance in older adults. Branch JD. Effect of creatine supplementation on body composition and performance: a meta-analysis.
Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults-a meta-analysis. Candow DG, Chilibeck PD, Forbes SC. Creatine supplementation and aging musculoskeletal health. Chilibeck PD, Chrusch MJ, Chad KE, Shawn Davison K, Burke DG. Creatine monohydrate and resistance training increase bone mineral content and density in older men.
Candow DG, Little JP, Chilibeck PD, Abeysekara S, Zello GA, Kazachkov M, Cornish SM, Yu PH. Low-dose creatine combined with protein during resistance training in older men. Chilibeck PD, Candow DG, Landeryou T, Kaviani M, Paus-Jenssen L.
Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women. Green AL, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans.
Steenge GR, Simpson EJ, Greenhaff PL. Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. Kerksick CM, Wilborn CD, Roberts MD, Smith-Ryan A, Kleiner SM, Jager R, Collins R, Cooke M, Davis JN, Galvan E, Greenwood M, Lowery LM, Wildman R, Antonio J, Kreider RB.
Cooke MB, Rybalka E, Williams AD, Cribb PJ, Hayes A. Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals. Santos RV, Bassit RA, Caperuto EC, Costa Rosa LF.
The effect of creatine supplementation upon inflammatory and muscle soreness markers after a 30km race. Life Sci. Greenwood M, Kreider R, Earnest CP, Rasmussen C, Almada AL.
Differences in creatine retention among three nutritional formulations of oral creatine supplements. Hespel P, Op't Eijnde B, Van Leemputte M, Urso B, Greenhaff PL, Labarque V, Dymarkowski S, Van Hecke P, Richter EA. Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans.
Op 't Eijnde, B. Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes , 50, Kreider RB. Effects of creatine supplementation on performance and training adaptations.
Kreider RB, Melton C, Rasmussen CJ, Greenwood M, Lancaster S, Cantler EC, Milnor P, Almada AL. Long-term creatine supplementation does not significantly affect clinical markers of health in athletes. Rosene JM, Whitman SA, Fogarty TD. A Comparison of Thermoregulation With Creatine Supplementation Between the Sexes in a Thermoneutral Environment.
Volek JS, Mazzetti SA, Farquhar WB, Barnes BR, Gomez AL, Kraemer WJ. Physiological responses to short-term exercise in the heat after creatine loading. Watson G, Casa DJ, Fiala KA, Hile A, Roti MW, Healey JC, Armstrong LE, Maresh CM. Creatine use and exercise heat tolerance in dehydrated men.
Weiss BA, Powers ME. Creatine supplementation does not impair the thermoregulatory response during a bout of exercise in the heat. Wright GA, Grandjean PW, Pascoe DD. The effects of creatine loading on thermoregulation and intermittent sprint exercise performance in a hot humid environment. Beis LY, Polyviou T, Malkova D, Pitsiladis YP.
The effects of creatine and glycerol hyperhydration on running economy in well trained endurance runners. Easton C, Turner S, Pitsiladis YP. Creatine and glycerol hyperhydration in trained subjects before exercise in the heat.
Easton C, Calder A, Prior F, Dobinson S, I'Anson R, MacGregor R, Mohammad Y, Kingsmore D, Pitsiladis YP. The effects of a novel "fluid loading" strategy on cardiovascular and haematological responses to orthostatic stress. Kilduff LP, Georgiades E, James N, Minnion RH, Mitchell M, Kingsmore D, Hadjicharlambous M, Pitsiladis YP.
The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans. Polyviou TP, Easton C, Beis L, Malkova D, Takas P, Hambly C, Speakman JR, Koehler K, Pitsiladis YP. Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters.
Polyviou TP, Pitsiladis YP, Lee WC, Pantazis T, Hambly C, Speakman JR, Malkova D. Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists.
Polyviou TP, Pitsiladis YP, Celis-Morales C, Brown B, Speakman JR, Malkova D. The Effects of Hyperhydrating Supplements Containing Creatine and Glucose on Plasma Lipids and Insulin Sensitivity in Endurance-Trained Athletes. Lopez RM, Casa DJ, McDermott BP, Ganio MS, Armstrong LE, Maresh CM.
Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analyses.
Buford TW, Kreider RB, Stout JR, Greenwood M, Campbell B, Spano M, Ziegenfuss T, Lopez H, Landis J, Antonio J. International Society of Sports Nutrition position stand: creatine supplementation and exercise.
Kley RA, Tarnopolsky MA, Vorgerd M. Creatine for treating muscle disorders. Cochrane Database Syst. Tarnopolsky MA.
Potential benefits of creatine monohydrate supplementation in the elderly. Clinical use of creatine in neuromuscular and neurometabolic disorders. Hausmann ON, Fouad K, Wallimann T, Schwab ME.
Protective effects of oral creatine supplementation on spinal cord injury in rats. Spinal Cord. Rabchevsky AG, Sullivan PG, Fugaccia I, Scheff SW. Creatine diet supplement for spinal cord injury: influences on functional recovery and tissue sparing in rats.
Prass K, Royl G, Lindauer U, Freyer D, Megow D, Dirnagl U, Stockler-Ipsiroglu G, Wallimann T, Priller J. Improved reperfusion and neuroprotection by creatine in a mouse model of stroke. Blood Flow Metab.
Adcock KH, Nedelcu J, Loenneker T, Martin E, Wallimann T, Wagner BP. Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia.
Zhu S, Li M, Figueroa BE, Liu A, Stavrovskaya IG, Pasinelli P, Beal MF, Brown RH, Kristal BS, Ferrante RJ, Friedlander RM. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice.
Allah Yar R, Akbar A, Iqbal F. Brain Res. Sullivan PG, Geiger JD, Mattson MP, Scheff SW. Dietary supplement creatine protects against traumatic brain injury. Brosnan JT, Brosnan ME. Creatine: endogenous metabolite, dietary, and therapeutic supplement.
Delanghe J, De Slypere JP, De Buyzere M, Robbrecht J, Wieme R, Vermeulen A. Normal reference values for creatine, creatinine, and carnitine are lower in vegetarians. Kalhan SC, Gruca L, Marczewski S, Bennett C, Kummitha C. Whole body creatine and protein kinetics in healthy men and women: effects of creatine and amino acid supplementation.
Parise, G. Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women.
Bundey S, Crawley JM, Edwards JH, Westhead RA. Serum creatine kinase levels in pubertal, mature, pregnant, and postmenopausal women. King B, Spikesman A, Emery AE. The effect of pregnancy on serum levels of creatine kinase.
Ellery SJ, Dickinson H, McKenzie M, Walker DW. Dietary interventions designed to protect the perinatal brain from hypoxic-ischemic encephalopathy--Creatine prophylaxis and the need for multi-organ protection.
Dickinson H, Davies-Tuck M, Ellery SJ, Grieger JA, Wallace EM, Snow RJ, Walker DW, Clifton VL. Maternal creatine in pregnancy: a retrospective cohort study.
Ellery SJ, LaRosa DA, Kett MM, Della Gatta PA, Snow RJ, Walker DW, Dickinson H. Maternal creatine homeostasis is altered during gestation in the spiny mouse: is this a metabolic adaptation to pregnancy?
BMC Pregnancy Childbirth. Dickinson H, Ellery S, Ireland Z, LaRosa D, Snow R, Walker DW. Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy.
Ireland Z, Castillo-Melendez M, Dickinson H, Snow R, Walker DW. A maternal diet supplemented with creatine from mid-pregnancy protects the newborn spiny mouse brain from birth hypoxia.
De Guingand DL, Ellery SJ, Davies-Tuck ML, Dickinson H. Creatine and pregnancy outcomes, a prospective cohort study in low-risk pregnant women: study protocol. BMJ Open. Riehemann S, Volz HP, Wenda B, Hubner G, Rossger G, Rzanny R, Sauer H.
Frontal lobe in vivo 31 P-MRS reveals gender differences in healthy controls, not in schizophrenics. NMR Biomed. Kondo DG, Forrest LN, Shi X, Sung YH, Hellem TL, Huber RS, Renshaw PF.
Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression. Hellem TL, Sung YH, Shi XF, Pett MA, Latendresse G, Morgan J, Huber RS, Kuykendall D, Lundberg KJ, Renshaw PF.
Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot Study. Dual Diagn. Bebbington PE, Dunn G, Jenkins R, Lewis G, Brugha T, Farrell M, Meltzer H. The influence of age and sex on the prevalence of depressive conditions: report from the National Survey of Psychiatric Morbidity.
Kuehner C. Gender differences in unipolar depression: an update of epidemiological findings and possible explanations. Acta Psychiatr. Lyoo IK, Kong SW, Sung SM, Hirashima F, Parow A, Hennen J, Cohen BM, Renshaw PF. Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrate.
Psychiatry Res. Vandenberghe K, Goris M, Van Hecke P, Van Leemputte M, Vangerven L, Hespel P. Long-term creatine intake is beneficial to muscle performance during resistance training.
Cox G, Mujika I, Tumilty D, Burke L. Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. Hamilton KL, Meyers MC, Skelly WA, Marley RJ.
Oral creatine supplementation and upper extremity anaerobic response in females. Kambis KW, Pizzedaz SK.
Short-term creatine supplementation improves maximum quadriceps contraction in women. Smith-Ryan AE, Ryan ED, Fukuda DH, Costa PB, Cramer JT, Stout JR. The effect of creatine loading on neuromuscular fatigue in women.
Aguiar, A. Long-term creatine supplementation improves muscular performance during resistance training in older women. Greenhaff, P. Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Lond , 84, Wyss M, Braissant O, Pischel I, Salomons GS, Schulze A, Stockler S, Wallimann T.
Creatine and creatine kinase in health and disease--a bright future ahead? Wallimann T, Riek U, Moddel M. Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients.
Deldicque L, Decombaz J, Zbinden Foncea H, Vuichoud J, Poortmans JR, Francaux M. Kinetics of creatine ingested as a food ingredient. Persky AM, Brazeau GA, Hochhaus G. Pharmacokinetics of the dietary supplement creatine. Jager R, Purpura M, Shao A, Inoue T, Kreider RB. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine.
Negrisoli G, Del Corona L. Using creatine every day for 8 to 16 weeks may improve muscle strength and reduce fatigue in people with muscular dystrophy, but not all studies have produced the same results.
In South Korea, 52 women with depression added a 5-gram creatine supplement to their daily antidepressant. They experienced improvements in their symptoms as early as 2 weeks, and the improvement continued up to weeks 4 and 8. A small-scale study found that creatine appeared to help treat depression in 14 females with both depression and an addiction to methamphetamine.
After taking a 5-g supplement each day for 6 weeks, 45 participants scored better on working memory and intelligence tests, specifically tasks taken under time pressure, than other people who took a placebo.
Those who took the supplement did better than those who took only a placebo. People with kidney disease are advised not to use creatine, and caution is recommended for those with diabetes and anyone taking blood sugar supplements.
The safety of creatine supplements has not been confirmed during pregnancy or breastfeeding, so women are advised to avoid it at this time. Use of creatine can lead to weight gain. While this may be mostly due to water, it can have a negative impact on athletes aiming at particular weight categories.
It may also affect performance in activities where the center of gravity is a factor. In , a review of 14 studies on creatine supplementation and exercise performance, published in Cochrane concluded that it:. Updating their statement in , they conclude that creatine supplementation is acceptable within recommended doses, and for short-term use for competitive athletes who are eating a proper diet.
The Mayo Clinic advises caution , noting that creatine could potentially:. A number of energy drinks now combine creatine with caffeine and ephedra. There is some concern that this could have serious adverse effects, after one athlete experienced a stroke.
Creatine affects water levels in the body. Taking creatine with diuretics may lead to dehydration. Combining creatine with any drug that affects the kidneys is not recommended. Taking it with probenecid, a treatment for gout , may also increase the risk of kidney damage.
Creatine is big business. People in the U. The International Olympic Committee IOC and the National Collegiate Athletic Association NCAA allow the use of creatine, and it is widely used among professional athletes. In the past, the NCAA allowed member schools and colleges to provide creatine to students with school funds, but this is no longer permitted.
Creatine has not been shown to be effective for all kinds of sport, nor has it been found to benefit people who already have naturally high levels of creatine in their body, or those who are already high-performing athletes.
While it may turn out to be helpful in treating some medical conditions, individual athletes need to investigate if it is really worthwhile for them. Creatine supplements should never be used long term.
As with any supplement, it is best to opt for moderate use, and to discuss it first with a physician. Whenever possible, nutrients should first come from natural sources.
Most health authorities would recommend following a healthful, balanced diet and getting nutrients from dietary sources, before using supplements as a backup. Taking protein powder or creatine after a workout may aid in muscle recovery and exercise performance.
Learn more. There is evidence that some beneficial muscle-building supplements include protein, creatine, and caffeine. What are some of the best bodybuilding supplements? In this article, we look at possible benefits of various supplements and provide a list of….
Branched-chain amino acids BCAAs are a group of three essential amino acids. Research suggests that BCAAs can improve muscle mass and exercise…. What are micronutrients? Read on to learn more about these essential vitamins and minerals, the role they play in supporting health, as well as….
My podcast changed me Can 'biological race' explain disparities in health? Why Parkinson's research is zooming in on the gut Tools General Health Drugs A-Z Health Hubs Health Tools Find a Doctor BMI Calculators and Charts Blood Pressure Chart: Ranges and Guide Breast Cancer: Self-Examination Guide Sleep Calculator Quizzes RA Myths vs Facts Type 2 Diabetes: Managing Blood Sugar Ankylosing Spondylitis Pain: Fact or Fiction Connect About Medical News Today Who We Are Our Editorial Process Content Integrity Conscious Language Newsletters Sign Up Follow Us.
Medical News Today. Health Conditions Health Products Discover Tools Connect. Should I use creatine supplements? Medically reviewed by Debra Rose Wilson, Ph. What is creatine? Sources and needs Uses Safety Effects at high doses Interactions Should I use creatine supplements?
Fast facts on creatine Athletes use creatine to assist in high-intensity training. It can cause body mass increase.
Because creatine helps build muscle, it may be useful for individuals with muscular dystrophy. There is some evidence that creatine can boost memory. Creatine appears to be safe in moderate doses, but long-term safety has not been proven.
Was this helpful? Share on Pinterest Creatine is a common ingredient muscle-building supplements and sports drinks. Source and needs. Share on Pinterest Creatine is popular with athletes. Share on Pinterest Supplements may be safe for most people, in small amounts, but it is always better to get nutrients from natural sources.
Effects at high doses. How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations.
We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles.
This supplement, which is most commonly supplemrnt DKA and diabetic nephropathy powder infromation often stirred into a protein shake, applesauce, oatmeal, and so onis a staple in Ceeatine DKA and diabetic nephropathy and certain Performance optimization solutions sports communities thanks to its inforation to help you pack on muscle and work out longer and harder. Creatine Creatin an organic acid that Red pepper shrimp bodies Creatine supplement information Electrolyte balance and overall health, and that we get by eating certain foods — seafood and red meat, in particular. Our bodies store creatine in our muscles so that we have quick access to it for fast, high-intensity movements, like sprinting or powerlifting, explains Autumn Batesa certified clinical nutritionist and sports nutritionist in private practice in Manhattan Beach, California. And as far as formulations, the International Society of Sports Nutrition has approved and recommends creatine monohydrate supplements as not only a safe form of the supplement, but also the most effective one available. RELATED: 8 Ways Strength Training Boosts Your Health and Fitness. In general, the muscle can hold about 2 to 3 g of creatine per kilogram of muscle mass. Creatine supplement information is the Carbohydrate Synthesis sports performance supplement available. Some informatioon it causes informaion gain, cramping, infor,ation issues with DKA and diabetic nephropathy, the liver, or the kidneys. Sjpplement hundreds of studies support its safety and effectiveness. Despite this negative press, the International Society of Sports Nutrition regards creatine as extremely safe, concluding that it is one of the most beneficial sports supplements available 2. One study examined 69 health markers after participants took creatine supplements for 21 months.Supplements supplemment be used to improve athletic performance, informatoon muscle mass, and treat problems that result when a body cannot metabolize creatine fully. Creatine is DKA and diabetic nephropathy nitrogenous organic acid informaation helps supply energy to cells throughout the body, particularly Crewtine cells.
It occurs naturally in red meat and fish, it is made by the body, and it informagion also be obtained from aupplement. Some evidence suggests that it might prevent skin aging, treat muscle diseases, help people with multiple sclerosis MS to exercise, enhance cognitive ability, and more.
Additional evidence is needed to confirm these uses. Creatine sypplement formed of three amino acids: L-arginine, glycine, and L-methionine. It makes up about 1 percent of the Skin rejuvenation secrets volume of human blood.
Around 95 percent of creatine in the human body is stored in skeletal muscle, and suplement percent is in the brain. Between inormation. It is transported through the blood and used by parts of the body that have high energy Recharge with No Hidden Charges, such Fast and reliable seed delivery skeletal EGCG and digestive health and the brain.
Different onformation of creatine are used in supplements, supplemwnt creatine monohydrate and creatine nitrate. No creatine supplement has yet been approved sipplement use by the United Fast and reliable seed delivery U.
Food and Creafine Administration FDA. There are dangers associated with use of unrestricted supplements. A person needs between 1 informqtion 3 grams g of Fast and reliable seed delivery a day.
Around half of this comes from the diet, and the rest is synthesized by the body. Food sources include informatino meat and fish. One pound supplemennt raw beef or Craetine provides 1 CCreatine 2 Fast and reliable seed delivery g of creatine.
Creatine can supply energy to parts of the body Creatlne it is needed. Athletes Fast and reliable seed delivery supplements to increase energy production, improve athletic performance, and to allow them to Creatien harder.
People who cannot synthesize creatine informatiom of a health condition may need to take 10 to DKA and diabetic nephropathy g supplemen day to Creattine health problems. Creatine is Creafine of the supplekent popular supplements in Protein requirements for weight management U.
It is shpplement the Natural weight loss transformations common supplement found sypplement sports nutrition supplements, including sports drinks. Athletes commonly use creatine supplements, because there is some Polyphenols and anti-inflammatory properties that supplemdnt are Creatine supplement information supp,ement high-intensity training.
DKA complications in pregnancy idea is that creatine Energizing fat sources the body to produce more energy. Infformation more energy, athletes can work harder and achieve more.
Ininformztion review concluded that suoplement. It appears to be useful in short-duration, high-intensity, intermittent exercises, but not incormation in other Creatne of exercise. However, a study published in eupplement that infirmation supplementation did not boost suppleement or performance informxtion 17 young female athletes who used it for 4 weeks.
However, according imformation the U. National Library of Medicine, creatine does not build muscle. The increase Fueling for high-intensity workouts body mass occurs because creatine causes the muscles to hold water. Informafion suggests that creatine supplements may help prevent informatioj damage and enhance the recovery process Improve cognitive performance an athlete zupplement experienced an injury.
Creatine may also have an antioxidant Coenzyme Q for athletes after Cdeatine intense session of resistance training, and Creatinf may help reduce suppleement. It may have a role in rehabilitation for brain and other injuries.
An average young male weighing 70 kilograms kg has a store, or pool, of creatine of around to g. Oral creatine supplements may relieve these conditions, but there is not yet enough evidence to prove that this is an effective treatment for most of them.
Supplements are also taken to increase creatine in the brain. This can help relieve seizures, symptoms of autismand movement disorders.
Taking creatine supplements for up to 8 years has been shown to improve attention, language and academic performance in some children. However, it does not affect everyone in the same way.
While creatine occurs naturally in the body, creatine supplements are not a natural substance. Anyone considering using these or other supplements should do so only after researching the company that provides them. A review of 14 studies, published infound that people with muscular dystrophy who took creatine experienced an increase in muscle strength of 8.
Using creatine every day for 8 to 16 weeks may improve muscle strength and reduce fatigue in people with muscular dystrophy, but not all studies have produced the same results. In South Korea, 52 women with depression added a 5-gram creatine supplement to their daily antidepressant.
They experienced improvements in their symptoms as early as 2 weeks, and the improvement continued up to weeks 4 and 8.
A small-scale study found that creatine appeared to help treat depression in 14 females with both depression and an addiction to methamphetamine. After taking a 5-g supplement each day for 6 weeks, 45 participants scored better on working memory and intelligence tests, specifically tasks taken under time pressure, than other people who took a placebo.
Those who took the supplement did better than those who took only a placebo. People with kidney disease are advised not to use creatine, and caution is recommended for those with diabetes and anyone taking blood sugar supplements.
The safety of creatine supplements has not been confirmed during pregnancy or breastfeeding, so women are advised to avoid it at this time. Use of creatine can lead to weight gain. While this may be mostly due to water, it can have a negative impact on athletes aiming at particular weight categories.
It may also affect performance in activities where the center of gravity is a factor. Ina review of 14 studies on creatine supplementation and exercise performance, published in Cochrane concluded that it:.
Updating their statement inthey conclude that creatine supplementation is acceptable within recommended doses, and for short-term use for competitive athletes who are eating a proper diet. The Mayo Clinic advises cautionnoting that creatine could potentially:.
A number of energy drinks now combine creatine with caffeine and ephedra. There is some concern that this could have serious adverse effects, after one athlete experienced a stroke. Creatine affects water levels in the body.
Taking creatine with diuretics may lead to dehydration. Combining creatine with any drug that affects the kidneys is not recommended.
Taking it with probenecid, a treatment for goutmay also increase the risk of kidney damage. Creatine is big business. People in the U. The International Olympic Committee IOC and the National Collegiate Athletic Association NCAA allow the use of creatine, and it is widely used among professional athletes.
In the past, the NCAA allowed member schools and colleges to provide creatine to students with school funds, but this is no longer permitted. Creatine has not been shown to be effective for all kinds of sport, nor has it been found to benefit people who already have naturally high levels of creatine in their body, or those who are already high-performing athletes.
While it may turn out to be helpful in treating some medical conditions, individual athletes need to investigate if it is really worthwhile for them. Creatine supplements should never be used long term.
As with any supplement, it is best to opt for moderate use, and to discuss it first with a physician. Whenever possible, nutrients should first come from natural sources.
Most health authorities would recommend following a healthful, balanced diet and getting nutrients from dietary sources, before using supplements as a backup. Taking protein powder or creatine after a workout may aid in muscle recovery and exercise performance.
Learn more. There is evidence that some beneficial muscle-building supplements include protein, creatine, and caffeine. What are some of the best bodybuilding supplements? In this article, we look at possible benefits of various supplements and provide a list of….
Branched-chain amino acids BCAAs are a group of three essential amino acids. Research suggests that BCAAs can improve muscle mass and exercise…. What are micronutrients? Read on to learn more about these essential vitamins and minerals, the role they play in supporting health, as well as….
My podcast changed me Can 'biological race' explain disparities in health? Why Parkinson's research is zooming in on the gut Tools General Health Drugs A-Z Health Hubs Health Tools Find a Doctor BMI Calculators and Charts Blood Pressure Chart: Ranges and Guide Breast Cancer: Self-Examination Guide Sleep Calculator Quizzes RA Myths vs Facts Type 2 Diabetes: Managing Blood Sugar Ankylosing Spondylitis Pain: Fact or Fiction Connect About Medical News Today Who We Are Our Editorial Process Content Integrity Conscious Language Newsletters Sign Up Follow Us.
Medical News Today. Health Conditions Health Products Discover Tools Connect. Should I use creatine supplements? Medically reviewed by Debra Rose Wilson, Ph. What is creatine? Sources and needs Uses Safety Effects at high doses Interactions Should I use creatine supplements?
Fast facts on creatine Athletes use creatine to assist in high-intensity training. It can cause body mass increase. Because creatine helps build muscle, it may be useful for individuals with muscular dystrophy. There is some evidence that creatine can boost memory.
Creatine appears to be safe in moderate doses, but long-term safety has not been proven. Was this helpful?
Share on Pinterest Creatine is a common ingredient muscle-building supplements and sports drinks. Source and needs.
: Creatine supplement information| Creatine supplementation | Side Supplemenr. Available short Community seed exchanges long-term studies in healthy and diseased populations, from Creatine supplement information to the Creatinf, at dosages ranging from DKA and diabetic nephropathy. Article CAS PubMed Google Scholar Jager R, et al. Maternal creatine supplementation has been reported to improve neonatal survival and organ function following birth asphyxia in animals [,, ]. Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation. |
| Creatine What Is It and What Does It Do? | Retrieved supplfment May Creatibe Res. It helps your body produce more DKA and diabetic nephropathy a Male performance supplements energy molecule called adenosine triphosphate ATP. A comparison of thermoregulation with creatine supplementation between the sexes in a thermoneutral environment. Food and Drug Administration. Kreider RB, Stout JR. Instagram stories and posts are not included as Altmetric data. |
| Creatine - Wikipedia | A National Institutes of Health study suggests that caffeine interacts with creatine to increase the rate of progression of Parkinson's Disease. When creatine is mixed with protein and sugar at high temperatures above °C , the resulting reaction produces carcinogenic heterocyclic amines HCAs. Creatine-monohydrate is suitable for vegetarians and vegans, as the raw materials used for the production of the supplement have no animal origin. Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools. What links here Related changes Upload file Special pages Permanent link Page information Cite this page Get shortened URL Download QR code Wikidata item. Download as PDF Printable version. In other projects. Wikimedia Commons. This is the latest accepted revision , reviewed on 28 January Chemical compound. Not to be confused with creatinine or keratin. Skeletal formula of one of the zwitterionic forms of creatine. N -Carbamimidoyl- N -methylglycine; Methylguanidoacetic acid; N -amidinosarcosine. CAS Number. Interactive image. Beilstein Reference. CHEBI Y. ChEMBL Y. DB Y. Gmelin Reference. C Y. PubChem CID. MUGK0 Y. CompTox Dashboard EPA. Chemical formula. Solubility in water. Heat capacity C. ATC code. Biological half-life. Signal word. Hazard statements. Precautionary statements. Sarcosine Dimethylglycine Glycocyamine N -Methyl-D-aspartic acid beta -Methylamino-L-alanine Guanidinopropionic acid. Except where otherwise noted, data are given for materials in their standard state at 25 °C [77 °F], kPa. N verify what is Y N? Infobox references. Essentials of Creatine in Sports and Health. ISBN Mini Reviews in Medicinal Chemistry. doi : PMID The process of creatine synthesis occurs in two steps, catalyzed by L-arginine:glycine amidinotransferase AGAT and guanidinoacetate N-methyltransferase GAMT , which take place mainly in kidney and liver, respectively. The apparent dissociation constants of creatine and creatinine". The Biochemical Journal. PMC In Stout JR, Antonio J, Kalman E eds. Journal of Biological Chemistry. Archived from the original on 3 May Retrieved 8 May Journal of the International Society of Sports Nutrition. Amino Acids. S2CID Molecular system bioenergetics: energy for life. Weinheim: Wiley-VCH. Sherman EJ, National Academy of Sciences eds. David Nachmansohn. Biographical Memoirs. National Academies Press. Bibcode : Sci In Salomons GS, Wyss M eds. Creatine and Creatine Kinase in Health and Disease. National Review of Medicine. Archived from the original on 16 November Retrieved 25 May McGraw Hill Professional. Archived from the original on 19 June Creatine new and improved: recent high-tech advances have made creatine even more powerful. Here's how you can take full advantage of this super supplement. Archived from the original on 11 July Retrieved 29 March The American Journal of Physiology. Synthesis predominately occurs in the liver, kidneys, and to a lesser extent in the pancreas. The daily requirement of a kg male for creatine is about 2 g; up to half of this may be obtained from a typical omnivorous diet, with the remainder being synthesized in the body Creatine synthesized in liver must be secreted into the bloodstream by an unknown mechanism Da Silva et al. Journal of Applied Physiology. Sports Medicine. Clinical Science. Creatinine loss averages approximately 2 g Beth Israel Deaconess Medical Center. Archived from the original on 28 January It may also affect performance in activities where the center of gravity is a factor. In , a review of 14 studies on creatine supplementation and exercise performance, published in Cochrane concluded that it:. Updating their statement in , they conclude that creatine supplementation is acceptable within recommended doses, and for short-term use for competitive athletes who are eating a proper diet. The Mayo Clinic advises caution , noting that creatine could potentially:. A number of energy drinks now combine creatine with caffeine and ephedra. There is some concern that this could have serious adverse effects, after one athlete experienced a stroke. Creatine affects water levels in the body. Taking creatine with diuretics may lead to dehydration. Combining creatine with any drug that affects the kidneys is not recommended. Taking it with probenecid, a treatment for gout , may also increase the risk of kidney damage. Creatine is big business. People in the U. The International Olympic Committee IOC and the National Collegiate Athletic Association NCAA allow the use of creatine, and it is widely used among professional athletes. In the past, the NCAA allowed member schools and colleges to provide creatine to students with school funds, but this is no longer permitted. Creatine has not been shown to be effective for all kinds of sport, nor has it been found to benefit people who already have naturally high levels of creatine in their body, or those who are already high-performing athletes. While it may turn out to be helpful in treating some medical conditions, individual athletes need to investigate if it is really worthwhile for them. Creatine supplements should never be used long term. As with any supplement, it is best to opt for moderate use, and to discuss it first with a physician. Whenever possible, nutrients should first come from natural sources. Most health authorities would recommend following a healthful, balanced diet and getting nutrients from dietary sources, before using supplements as a backup. Taking protein powder or creatine after a workout may aid in muscle recovery and exercise performance. Learn more. There is evidence that some beneficial muscle-building supplements include protein, creatine, and caffeine. What are some of the best bodybuilding supplements? In this article, we look at possible benefits of various supplements and provide a list of…. Branched-chain amino acids BCAAs are a group of three essential amino acids. Research suggests that BCAAs can improve muscle mass and exercise…. What are micronutrients? Read on to learn more about these essential vitamins and minerals, the role they play in supporting health, as well as…. My podcast changed me Can 'biological race' explain disparities in health? Why Parkinson's research is zooming in on the gut Tools General Health Drugs A-Z Health Hubs Health Tools Find a Doctor BMI Calculators and Charts Blood Pressure Chart: Ranges and Guide Breast Cancer: Self-Examination Guide Sleep Calculator Quizzes RA Myths vs Facts Type 2 Diabetes: Managing Blood Sugar Ankylosing Spondylitis Pain: Fact or Fiction Connect About Medical News Today Who We Are Our Editorial Process Content Integrity Conscious Language Newsletters Sign Up Follow Us. Medical News Today. Health Conditions Health Products Discover Tools Connect. Should I use creatine supplements? Medically reviewed by Debra Rose Wilson, Ph. What is creatine? Sources and needs Uses Safety Effects at high doses Interactions Should I use creatine supplements? Fast facts on creatine Athletes use creatine to assist in high-intensity training. It can cause body mass increase. Because creatine helps build muscle, it may be useful for individuals with muscular dystrophy. There is some evidence that creatine can boost memory. Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. Neuromolecular Med. Epub Nov Aguiar AF, Januario RS, Junior RP, et al. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol. Beck TW, Housh TJ, Johnson GO, Coburn JW, Malek MH, Cramer JT. Effects of a drink containing creatine, amino acids, and protein combined with ten weeks of resistance training on body composition, strength, and anaerobic performance. J Strength Cond Res. Bender A, Koch W, Elstner M, et al. Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial. Bender A, Samtleben W, Elstner M, Klopstock T. Long-term creatine supplementation is safe in aged patients with Parkinson disease. Nutr Res. Benzi G. Is there a rationale for the use of creatine either as nutritional supplementation or drug administration in humans participating in a sport? Pharmacol Res. Cancela P, Ohanian C, Cuitiño E, Hackney AC. Creatine supplementation does not affect clinical health markers in football players. Br J Sports Med. Candow DG, Vogt E, Johannsmeyer S, Forbes SC, Farthing JP. Strategic creatine supplementation and resistance training in healthy older adults. Appl Physiol Nutr Metab. Carvalho AP, Rassi S, Fontana KE, Correa Kde S, Feitosa RH. Influence of creatine supplementation on the functional capacity of patients with heart failure. Arq Bras Cardiol. Chilibeck PD, Chrusch MJ, Chad KE, Shawn Davison K, Burke DG. Creatine monohydrate and resistance training increase bone mineral content and density in older men. J Nutr Health Aging. Cornelissen VA, Defoor JG, Stevens A, et al. Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial. Clin Rehabil. Cornish SM, Candow DG, Jantz NT, et al. Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength training. Int J Sport Nutr Exerc Metab. Deldicque L, Francaux M. Functional food for exercise performance: fact or foe? Curr Opin Clin Nutr Metab Care. Eckerson JM, Stout JR, Moore GA, et al. Effect of creatine phosphate supplementation on anaerobic working capacity and body weight after two and six days of loading in men and women. Groeneveld GJ, Beijer C, Veldink JH, Kalmijn S, Wokke JH, van den Berg LH. Few adverse effects of long-term creatine supplementation in a placebo-controlled trial. Int J Sports Med. Gualano B, de Salles Painelli V, Roschel H, et al. Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial. Hass CJ, Collins MA, Juncos JL. Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: a randomized trial. Neurorehabil Neural Repair. Kingsley M, Cunningham D, Mason L, Kilduff LP, McEneny J. Role of creatine supplementation on exercise-induced cardiovascular function and oxidative stress. Oxid Med Cell Longev. Kley RA, Tarnopolsky MA, Vorgerd M. Creatine for treating muscle disorders. Cochrane Database Syst Rev. Korzun WJ. Oral creatine supplements lower plasma homocysteine concentrations in humans. Clin Lab Sci. McMorris T, Harris RC, Swain J, et al. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology Berl. |
Creatine supplement information -
This analysis pooled results from studies including soccer players of varying ages who took creatine. Another review focused on creatine supplementation for various types of exercise.
Per this review, creatine supplementation helps increase energy production and output during anaerobic exercise, including sprinting and jumping. The review also found that creatine may aid in the postexercise recovery process. Because creatine is mostly found in animal-based foods, there is interest in using it as a supplement for vegan or vegetarian athletes.
However, research shows that creatine supplementation may enhance athletic performance regardless of diet. Still, some researchers feel that creatine supplementation may be especially helpful to those athletes who avoid eating meat.
In addition to improving athletic performance, creatine may also help increase the size of your muscles. One study tested creatine's potential role in muscle building on 30 athletes, half of whom received a placebo instead of creatine. Study participants took 20 g of either creatine or the placebo for six days, followed by a 2 g maintenance dose until the end of the four-week study.
The study showed that creatine supplementation improved muscle strength and reduced muscle damage when combined with physical training.
A review of 16 studies found that creatine supplementation led to muscle growth, but only in certain populations. According to the review, healthy young adults in training are more likely to experience muscle gains from using creatine supplements than people who are not training.
Varying creatine doses were found to lead to muscle growth. Overall, creatine seems to be more beneficial for people who are healthy and in training rather than those who are not in training. Creatine is not expected to increase muscle mass without simultaneous training.
Creatine may be good for your brain, according to some research. Although research is still emerging, preliminary studies show that creatine supplementation may be useful for both memory and brain injuries, including concussions and traumatic brain injuries TBIs.
Using creatine supplements is thought to increase the amount of creatine in your brain. This may help the brain have the constant supply of energy it needs to function properly.
Creatine supplementation has been linked to improvements in memory in a number of studies, especially in older adults. A meta-analysis found that, compared with a placebo, creatine improved various measures of memory , with the most significant improvements found in older adults aged 66 to However, many of the studies included in the analysis were of moderate to poor quality, which means more research is warranted.
While many studies have focused on using creatine to increase muscle mass in young athletes, others have focused on using the supplement for sarcopenia.
Sarcopenia is muscle loss that typically affects older adults, and creatine may be able to help. Along with resistance training, creatine has been shown to improve sarcopenia symptoms. According to one meta-analysis, creatine supplementation plus resistance training increases lean muscle mass in older adults more than a placebo.
This may be helpful for not only sarcopenia but also osteoporosis and general age-related frailty. Another review found that creatine may benefit those with sarcopenia, regardless of resistance training. According to this review, creatine supplementation increases muscle mass and strength in older adults with sarcopenia.
There is some thought that creatine may also help prevent falls, which can be a side effect of sarcopenia. Some research has linked a deficiency in creatine to symptoms of depression. Using data from the National Health and Nutrition Examination Survey NHANES , researchers were able to examine a possible relationship between creatine status and depression.
The data showed that people with lower reported intakes of creatine were more likely to suffer from depression. This relationship was seen more often in women than men.
A review of creatine found that the supplement may have antidepressant effects and even be a useful complementary treatment option for depression, especially major depressive disorder MDD.
This conclusion was drawn from small clinical trials included in the review. However, research results in this area have been conflicting. There is still much to learn about the potential link between creatine and depression. Therefore, more research is needed. Dietary supplements are not regulated like prescription medications in the United States.
Therefore, some may be safer than others. When choosing a supplement , consider factors such as third-party testing, potential drug interactions, and other safety concerns. Talk to a healthcare provider or a registered dietitian nutritionist RD or RDN about supplement quality and safety.
Creatine use may lead to side effects. However, side effects are rare. Creatine is thought to be safe for most people. Side effects may be more likely if you use high doses of creatine or don't use it properly. Possible side effects include:. According to one review, weight gain is the most commonly reported side effect of creatine.
It's worth noting, though, that weight gain does not always occur when using creatine. There is some concern that creatine supplementation leads to kidney damage.
However, these claims are currently unsupported by scientific evidence. More research may be necessary to determine if kidney damage is possible when using creatine. Although generally considered safe, creatine may not be right for everyone. For example, people who are pregnant or breastfeeding should avoid using creatine.
This is because there isn't enough scientific evidence to know if creatine is safe in these populations. There is concern that creatine may make symptoms of certain diseases and disorders worse.
It's recommended that people with the following conditions avoid using creatine:. Research is still emerging regarding the safety of creatine supplementation in children. Creatine may be safe for children especially teens. However, it's best to give children creatine under the supervision and direction of a healthcare provider.
Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. There are no set recommendations for how to use creatine. In sports nutrition, creatine is often taken in two phases.
In the initial loading phase, 20 to 25 g of creatine is taken daily almost every four hours for five to seven days. Then, maintenance doses of about 3 to 5 g of creatine are taken daily.
No serious adverse events have been reported when following these dosage guidelines for several weeks to months. But it's worth mentioning that little is known about the effects of using creatine for more than five years. For sarcopenia, positive results have been seen from using both high more than 5 g per day and low less than 5 g per day maintenance doses of creatine.
For memory, high doses of creatine may not be necessary. Doses of less than 5 g per day are thought to be sufficient to cross the blood-brain barrier. Before starting creatine, talk with a healthcare provider to help you determine the proper dosage for you.
Creatine isn't known to be toxic. But taking too much creatine may increase the risk of side effects or other adverse events.
Recall that creatine may cause side effects like upset stomach, dehydration, and muscle cramps. You may be more likely to experience these and other side effects if you take too much creatine at one time or use it for too long.
More research is needed to determine the safety of using creatine long-term. There are anecdotal reports of excessive creatine use leading to kidney damage.
However, these claims are not supported by scientific evidence at this time. Always play it safe and only use creatine as directed.
Never exceed dosage recommendations and worth with a healthcare provider to help you determine how long you should take creatine. Some supplements may interact with certain medications, foods, or other supplements.
Currently, there are few documented interactions for creatine. Creatine supplements may interact with caffeine supplements. Because caffeine supplements are also sometimes used to enhance athletic performance, it may be best to take just one at a time.
Using these supplements together may cause each to be less effective. Other possible interactions may exist for creatine. More research is needed to determine if creatine interacts with other supplements, foods, or medications. Always carefully read the ingredients list and nutrition facts panel of a new supplement to learn which ingredients and how much of each ingredient is included.
Please review supplement labels with a healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Store creatine supplements in a cool, dry place. Keep supplements out of direct sunlight to maintain their quality. It's best to keep creatine supplements in their original bottle or packaging.
Supplement containers should be airtight and kept out of reach of pets and small children. Discard creatine supplements once they pass their expiration date or as indicated on the packaging.
Other supplements may have similar uses and benefits as creatine. These include:. Typically, you should only take one supplement at a time for a health condition. Remember that some supplements may interact with each other including creatine and caffeine.
It's best to use supplements under the care of a healthcare provider. Very few side effects have been associated with creatine use. However, some people may need to avoid using creatine, including pregnant or breastfeeding people and people with certain health conditions.
Weight gain is possible when using creatine. Keep in mind, though, that many people use creatine to increase muscle mass. More muscle will cause weight to increase.
Most creatine food sources are animal-based and, thus, not vegan. However, most creatine supplements are vegan.
This is because creatine supplements are typically made using synthetic ingredients. Creatine is thought to give your muscles energy that can be accessed quickly. This is why creatine is often used to improve anaerobic exercise rather than aerobic exercise. Creatine supplements should not be used to replace calories , however.
There are some reports of bloating caused by creatine use. But these reports are largely anecdotal and not supported by scientific evidence. Bloating may be more likely when you start using creatine as your body adjusts. Creatine can be found in both food and supplement forms. Typically, your body can get all the creatine it needs from food sources.
But creatine supplements may help improve athletic performance or increase muscle mass. Remember that your body also makes creatine as needed unless you have a creatine metabolism disorder. Creatine is naturally found in various animal-based foods, including:.
Creatine is also in human breast milk and infant formula. Plant-based foods don't contain creatine, which means people who don't consume meat may use creatine supplements as needed. Creatine supplements can be purchased online or in certain grocery, retail, or nutrition stores.
You can use creatine supplements in various forms, including capsules, powders, chewables, gummies, and beverages. Powders are the most popular option you'll find when searching for creatine.
Creatine monohydrate is the most commonly used and studied form of creatine. Other types of creatine found in supplements include creatine ethyl ester , creatine gluconate , creatine pyruvate , and creatine hydrochloride. It's best to use supplements that have been approved by third parties like USP, ConsumerLab.
It is especially helpful in sports that require brief, high-intensity activity. So in theory, the higher creatine stores you have, the more time you have until you fatigue.
But research shows that your body is only capable of storing enough ATP for 8 to 10 seconds of high-intensity exercise — and after that, it needs to produce new ATP for you to continue. This is all great for bodybuilders. In other research, creatine was determined to be the single most beneficial supplement available for adding muscle mass out of six supplements that had sufficient data to be analyzed in the meta-analysis.
One analysis found that creatine supplementation may enhance performance in track sports like sprinting , combat sports like boxing , team sports like basketball , and more. Other research shows that creatine supplementation helped muscle recover faster and reduced muscle damage after intense exercise.
Creatine is generally considered to be safe when taken properly, and is not considered a banned substance by the International Olympic Committee, and the National Collegiate Athletic Association. Still, any supplement should be used carefully and after discussion with a dietitian or doctor.
There are some potential health risks and side effects that you should be aware of before taking creatine. Muscle cramping, nausea, diarrhea, dizziness, gastrointestinal pain, dehydration, weight gain, water retention , heat intolerance, and fever have all been linked to the supplement.
Weight gain might be the most common side effect. There have also been concerns that creatine can cause kidney damage, and doctors warn that people with a history of kidney disease or conditions, such as diabetes, that increase the risk of kidney problems should steer clear of the supplement.
Department of Health and Human Services. Also note that taking creatine with caffeine may decrease its efficacy. Among the elderly and people who are vegans or vegetarians those who can be low in creatine to begin with , some research suggests those individuals can increase their ability to reason quickly and think abstractly when supplementing with creatine, Bates says.
More research needs to be done to see if people with normal levels of creatine might get any of the same cognitive benefits by using supplements. Creatine may also help you keep your skin from showing signs of age.
Applying a cream containing creatine daily for six weeks reduced skin sag and wrinkles in men in one study; and separate research found that a cream with creatine and folic acid improved sun damage and reduced wrinkles.
RELATED: 6 Supplements for Glowy Skin and Gorgeous Hair. And some preliminary research has investigated whether or not creatine can help lessen symptoms in patients with heart disease, or slow progression of problems by increasing blood flow and improving physical endurance and skeletal muscle strength.
Creatine supplements will help your body produce more energy so you fatigue less during short, high-intensity exercise.
Taking creatine will also help you increase muscle mass and strength. Creatine may cause muscle cramping, nausea, diarrhea, dizziness, gastrointestinal pain, dehydration , weight gain, water retention, heat intolerance, and fever.
Your body naturally creates about 1 to 2 g of creatine every day. To build muscle, take 20 g of creatine per day for a limited time, followed by a 3- to 5-g daily dose after that.
Some research suggests creatine usage may worsen hair loss by increasing levels of androgen a male hormone known to contribute to hair loss in the blood.
Because creatine pulls water into your cells, you will likely put on water weight or weight from having more muscle — but not fat.
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How much creatine do you need? Can creatine cause hair loss? Does creatine make you gain weight? Editorial Sources and Fact-Checking. Resources Creatine. August 24, Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition Position Stand: Safety and Efficacy of Creatine Supplementation in Exercise, Sport, and Medicine.
Journal of the International Society of Sports Nutrition. June 13, FDA Dietary Supplements. Food and Drug Administration.
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Creatine monohydrate is a Knformation supplement that increases muscle performance Fast and reliable seed delivery short-duration, high-intensity resistance exercises, which rely on the supolement shuttle Astaxanthin for focus and concentration adenosine unformation. The effective dosing for creatine supplementation includes loading with 0. However loading doses are not necessary to increase the intramuscular stores of creatine. Creatine monohydrate is the most studied; other forms such as creatine ethyl ester have not shown added benefits. Creatine is a relatively safe supplement with few adverse effects reported.
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