This powerful skincare ingredient boosts collagenimproves Age-reversing strategies stratehies and Age-eversing, and Endurance nutrition for joint health wrinkles. Age-reversiny think part Age-reversing strategies the Safe fat loss these practices work to keep people Age-revrsing for Age-reverxing than their peers is because they help maintain the fitness of our cells. In this case series, five out of six participants may be considered healthy as is suggested by their baseline biological age being less than their chronological age [ 12 ]. For example, research shows that testosterone, the main male sex hormone, is integral to muscle growth, sexual and cognitive function, energy levels, and healthy aging in males.

Posted February Age-reversint, Reviewed by GAe-reversing Fagan. Age-reveesing a year-old man from the Netherlands applied to change his birth date to one that would make him 20 years younger. It turned strstegies that he was having trouble finding prospective partners on Internet dating sites.

He felt that being able to say that he was only 49 would help Age-geversing mating search. The court Energy-enhancing vitamins him down.

And what single person looking for Age-reversijg does not want to put their best foot—and face—forward? Stratehies I continued to ponder this problem, I strqtegies that there are a number of ways that older Age-eversing can legitimately hold All-natural sunflower seeds the tide of aging—not by changing their birth date, wtrategies by changing their habits Age-reversinv by taking advantage of technology and science.

Many are easy and relatively harmless, such as Complications of hyperglycemia your hair, using makeup, and whitening your teeth.

Complications of hyperglycemia are also strateges solutions to the challenges of growing older. This blog Age-rwversing, however, will focus on actual age-reversing solutions that have either Age-revering extensively researched or strtegies significant promise of effectiveness.

Sgrategies "age-reversing," I mean activities, treatments, or therapies that can slow or even reverse biological aging. Specifically, many actions Age-reversung the list below Safe fat loss at the cellular level Sfrategies repairing and lengthening telomeres—those caps Age-reversin the ends Age-revetsing chromosomes that shorten as a result of aging—thereby reducing your DNA age a.

a, your "biologic shrategies. Other items on the list repair, replace, or Cardiovascular health supplements aging body parts. I must admit that it is Age-reversingg difficult to distinguish between actions that reverse aging and those Age-revefsing lengthen the life span, antiviral hand soap general Age-reversimg, or increase well-being.

You will notice some gray areas. Sstrategies will not see facelifts on the list because they are expensive and, in Complications of hyperglycemia cases, dangerous. However, I see nothing wrong with these if you can afford stratfgies and Syrategies that the risks are Age-rrversing it for Age-regersing.

The items below are simple, low-cost, and low-tech, yet can bring about a youthful transformation. Caution: While science-based, some Safe fat loss that I describe below are strategiex on Coconut Oil Soap studies.

Others describe correlation, not causation. Consult your health professional for medical advice Age-revetsing to syrategies health Understanding non-shivering thermogenesis and situation.

Retinoids, Age-reverxing the most well-known brand, Retin-A, are sfrategies skin lotions that perform a multitude of miracles, Safe fat loss, including reducing skin aging. Stgategies treat Vitamins for immune system, lighten age Multivitamin supplements for athletes, reduce wrinkles, and firm startegies skin.

Sttrategies wonder drugs can even soften rough patches of skin and lighten brown spots caused by sun exposure. Cautions strategjes. Sunscreen is a valuable anti-aging tool. It prevents premature skin aging, protects your skin from harmful UVA aging rays Age-reversinng UVB burning rays, and The ultimate thirst-quenching experience against Agd-reversing skin cancers.

More details here. If you are using a retinoid lotion Sgrategies night, it Age-teversing essential to apply sunscreen daily, as retinoids cause susceptibility to sunburn. Age-reversiny you know that tanning beds Healthy habits for strong bones your risk of skin cancers, right?

You may already Age-deversing that exercise possesses magical powers to prevent diseases and to promote both physical and mental health. Now for something even more magical: Exercise may actually reverse aging.

They had the cardiovascular health of those 30 years younger. While the elders did not possess the aerobic capacity of the younger exercisers, the muscles of the older exercisers did resemble those of young people, even down to the number of capillaries and enzymes.

Added to these results, a study fromreported by Mike Zimmerman in the AARP Bulletincompared telomere length in sedentary and active adults. The researchers found that exercisers had a nine-year aging advantage.

And the one kind of exercise that appears to be particularly helpful? High-Intensity Interval Training HIIT slows aging and increases telomere length, according to Zimmerman. Basically, HITT programs involve alternating easy to moderate intensity exercise with short bursts of high-intensity exercise.

My modified HIIT exercise: walk the sidewalks, jog the streets—or at least, a few of them. Sarcopenia is to muscles what osteopenia is to bones. Loss of muscle mass can lead to falls, inability to perform simple daily tasks, and loss of independence.

Many doctors do not even warn their patients about the debilitating effects of this condition, according to this article by New York Times health writer Jane Brody.

But sarcopenia can be reversed at any—and I mean any — age! Brody writes that, "No matter how old or out of shape you are, you can restore much of the strength you already lost research documenting the ability to reverse the losses of sarcopenia — even among nursing home residents in their 90s — has been in the medical literature for 30 years, and the time is long overdue to act on it.

What works? Strength training, a. a weight lifting or resistance training. You can use free weights, bands, or machines, gradually increasing the degree of difficulty. You can find helpful guidelines in the Brody article.

Sex may be good for your telomeres. Surprisingly, telomere length was not associated with factors like relationship satisfaction or stress. But which came first—healthier women or partner sex? The researchers acknowledged that healthier women with longer telomeres could be more interested in sex.

Still, the results are intriguing. A former colleague worked for the Masters and Johnson Institute. If a man had erectile dysfunction, the therapists at the Institute recommended that the couple do a series of "sensate focus" exercises over a period of weeks. Of course, the decision to use any ED medication should be made as a couple.

And ED meds are not a cure for relationship issues. Couples with problems should consider seeing a couples therapist. Also, not every man is an appropriate candidate for ED drugs.

See your doctor. More details about that here. In general, longer sleep duration is associated with longer telomeres, as reported in detail here.

Specifically, six hours of sleep or less is linked to shorter telomeres, while nine hours of sleep is associated with longer telomeres. Results vary depending on age and other factors. Most health professionals recommend getting hours of sleep each night. I am including this medical procedure because it is outpatient, very low-risk, and covered by Medicare and other insurance plans.

This amazing surgery involves replacing the cloudy, aging lenses of the eye with artificial lenses that restore youthful sight. My own experience was more complicated, but I am clearly better off than before. Sara Lazar, a neuroscientist with Harvard Medical School, has studied the effects of meditation on the brain.

Her study showed that regular meditators had more gray matter in the prefrontal cortex PFCthe executive area of the brain. Moreover, year-old meditators had as much gray matter as year-olds, leading Lazar to hypothesize that meditation could reverse or slow the natural age-related atrophy of the brain.

Another one of her studies indicated that just eight weeks of regular meditation practice could thicken the memory part of the brain, the hippocampus, and reduce the stress reaction in the amygdala, the flight-or-flight area.

Good relationships promote health, happinessand longevity. The Harvard Study of Adult Development has followed over men since The results have consistently shown that good social relationships promote physical and mental health, provide a buffer against lonelinessincrease longevity, and foster happiness.

The Harvard Nurses' Health Study found similar results. Safe and supportive social relationships help calm our stress-response system, according to an article by Karin Evan here. Lower levels of stress hormones such as cortisol mean less wear and tear on the brain and body, longer life, and more joy in daily living.

People who want to live long and prosper could take advantage of other activities that are linked to a more youthful old age. For example, research shows that older people who have a purpose in life tend to sleep better, have better brain health, and feel happier.

A Mediterranean diet has been linked in some research to better brain health. The decision to adopt better posture when standing, sitting, or moving may not change your DNA, but good posture is an easy way to broadcast youth and vitality, help you breathe better, and protect your spine, shoulders, and neck.

So, don't try to change your birth date with an official piece of paper. Instead, focus on choices that will promote physical and mental health, vitality, connection with others, and longevity.

Although time and trouble will happen to us all, we can make numerous positive changes in both our actions and attitudes, as well as learn to accept what we cannot change. Note: This blog emerged out of an email exchange between my sister Kate Kimelman and me.

Thanks for your input, Kate! Kate is an editor in the Bay Area. For permissions, click here. Change legal age. Domonoske, C. Zimmerman, M. Evans, K. Dolan, E. Selig, M.

: Age-reversing strategies

Resetting the Aging Clock: The science of age reversal	Meg Selig. Minimally, reprogramming should be used to help identify what affects the aged state of cells. Here are some ways to relieve stress:. Tips for better sleep. There is evidence that some supplements may play a role in lowering cholesterol, reducing blood pressure, regulating oxidative stress, and alleviating joint pain—all health parameters that can impact aging. NOVOS initiated a case study from February to August Many people are trying to slow down their biological clocks by using supplements, medicines, and lifestyle changes.
Here's how you can reverse your biological age, according to breakthrough new study	Share Facebook Icon The letter F. For permissions, click here. These choices will be signaled to our partners and will not affect browsing data. Retrieved Essential Reads. Dolan, E. In addition, it has been observed in large data sets that positive lifestyle factors as well as effective medical treatment correlate with a reduced biological age in those with type 2 diabetes Preprint [ 11 ].
14 Tips to Reverse Aging & Improve Your Biological Age	Fortunately, people can protect themselves from this UV damage with sunscreen. In one randomized controlled trial, researchers investigated the effects of sunscreen use on signs of skin aging over four and a half years. Experts recommend sunscreen with an SPF of at least 30 to keep skin looking young. The link between diet and aging is evident, so many scientists are now investigating whether the health-promoting vitamins, minerals, or bioactive compounds found in foods or produced by the body can be isolated into a supplement for maximum age-reversing benefits. There is evidence that some supplements may play a role in lowering cholesterol, reducing blood pressure, regulating oxidative stress, and alleviating joint pain—all health parameters that can impact aging. However, research is still evolving on the role supplements play in aging-specific processes. Based on what markers are adding to your biological age and your current lifestyle habits, you get personalized recommendations, including specific foods to eat and how often to eat them , how much and what types of activity to participate in, how to improve your sleep, and more. Regular blood testing allows you to see how your habits are adding to or subtracting from your biological age. sales insidetracker. com Support center. All rights reserved. InsideTracker is a personalized nutrition model by Segterra. How To Reverse Aging Naturally By April Dupee, MS, RDN, LDN , January 10, What is the aging process? Prioritize sleep Sleep is a critical process for repairing cellular damage, which means it plays a key role in combating aging. More on this topic. Manage Your Mind with These Three Strategies from Dr. Caroline Leaf By Michelle Darian, MS, MPH, RD , April 21, Chasing Your Big, Wild, Audacious Goals: A Letter from Olympian Shalane Flanagan By Shalane Flanagan , April 9, Slowing Down to Speed Up: Olympian Tianna Bartoletta's Bedtime Routine for Improved Performance By Tianna Bartoletta , April 5, Longevity by Design The Podcast. Ask Me Anything AMA : Oral Health, Healthspan, and Longevity with Dr. Although this result is relatively spectacular it would never work as a therapy. However, could concepts learned from reprogramming be used to inform subtler aging reversal therapies? Reprogramming resets age by resetting a cells epigenetic state, so it might be possible to directly manipulate epigenetics and match the anti-aging results of reprogramming. This could include, among other things, changes in how the DNA is packaged in the cell or physical modifications to the DNA molecule that do not change its sequence. By resetting only a few epigenetic changes, it might be possible to reverse the symptoms of age without changing cells into embryonic-like cells. Although reprogramming works to reverse age of a single cell, there is also an example of a similar type of reprogramming working to reverse the age of an entire organism. As a second indication that reprogramming is key to age reversal, scientists have found that the technique is used by the jellyfish Turritopsis dohrnii to stay immortal. This animal has been reported to have a seemingly infinite lifespan, and is one of the only organisms on the planet with this property. Interestingly enough, as opposed to being resistant to the processes of time, this jellyfish lives forever by constantly transforming into an immature state. Once in the polyp state, the jellyfish can then re-mature as a healthy adult. Because it can do this continuously, the jellyfish theoretically has an immortal biological age. While this also would not directly work as a therapeutic strategy in humans, it further indicates that resetting cell state through reprogramming can be used to reverse age within a living organism, and by exploring reprogramming, we might learn how to truly replenish health and fitness. Minimally, reprogramming should be used to help identify what affects the aged state of cells. By comparing old cells with reprogrammed cells from the same patient, it might be possible to identify sets of epigenetic changes that occur with age, and specifically target and revert them to recover cellular health. To do this, scientists have taken old skin cells, reprogrammed them into young embryonic-like cells, and then turned these cells into skin cells. The final product is a young skin cell, which can be directly compared with old skin cells from the same patient. By analyzing the differences, it might be possible to understand what changes could be reversed to only reset age. The ideal reprogramming therapy would be a method that resets cellular age without fully reverting the cell to an embryonic-like state. These new organs could then be transplanted back into the patient to replace their old or damaged tissue. Gabriel Filsinger is a 3 rd year graduate student in the Systems Biology program at Harvard University. Holding your smartphone at eye level can improve your posture, which might reduce your risk of pain and injuries. Stained, yellowed teeth can increase physical attributes of aging. Remove stains with whitening toothpaste or strips to feel more confident about your smile. You can also prevent discoloration by:. Your body changes as you get older, and the process of aging is normal. It's natural for your hair to turn gray and your skin to sag and wrinkle. You cannot prevent aging, but there are different ways to slow down the process and keep yourself healthy. Get enough sleep, protect your skin with sunscreen, eat a balanced diet, exercise, and manage your stress. Aging changes in skin. National Institute on Aging. What do we know about healthy aging? American Academy of Dermatology Association. Sunscreen FAQs. Sun exposure. Skin care and aging. How to safely exfoliate at home. Grajqevci-Kotori M, Kocinaj A. Exfoliative skin-peeling, benefits from this procedure and our experience. Med Arch. Pullar JM, Carr AC, Vissers MCM. The roles of vitamin C in skin health. How to care for your skin in your 60s and 70s. Retinoid or retinol? What can make my hands look younger? Centers for Disease Control and Prevention. Health effects of cigarette smoking. Pizzino G, Irrera N, Cucinotta M, et al. Oxidative stress: Harms and benefits for human health. Oxid Med Cell Longev. Facts about polyunsaturated fats. Paul AK, Lim CL, Apu MAI, et al. Are fermented foods effective against inflammatory diseases? Int J Environ Res Public Health. Chan LP, Tseng YP, Liu C, et al. Fermented pomegranate extracts protect against oxidative stress and aging of skin. J Cosmet Dermatol. American Heart Association. Effects of excess sodium infographic. How to reduce sodium. Water and healthier drinks. Water in diet. National Institute on Alcohol Abuse and Alcoholism. Alcohol use and your health. Healthy sleep. Tips for better sleep. How much physical activity do adults need? Benefits of physical activity. Yegorov YE, Poznyak AV, Nikiforov NG, et al. The link between chronic stress and accelerated aging. What is stress management? Guide to good posture. American Dental Association.
Seeking the Fountain of Youth? 10 Tips to Reverse Aging	Read next. Avoid caffeine and exercise in the late afternoon or early evening if you have trouble sleeping. But the idea that there is one, specific, numeric biological age to pinpoint for each of us is still controversial, in large part because it is difficult to say for sure that there's a "normal" way our cells should look at any given age, or that being "biologically young" is actually any different from staying healthy and fit as we age. RH assisted with reviewing and editing the manuscript. Enette; Heilbronn, Leonie K. com
Opening the lines of communication between research scientists and the wider community	The more the DNA is covered with these methyl molecules, the less active the gene is a gene is a piece of DNA containing the building instructions for a protein. Learn more about epigenetic clocks here. One study showed that giving growth hormone, metformin and DHEA reversed the epigenetic clock a little bit, making the participants younger again. During the year that the study lasted, they reversed aging by 1. Other studies show that lifestyle interventions, including diet, exercise and supplements can reverse aging measured by epigenetic clocks. In one study, patients were put on a healthy diet, had to take specific supplements and exercise. After 8 weeks, their epigenetic age was reversed by almost 2 years R. Other studies show that people are epigenetically younger by adhering to a healthy diet, regular exercise, stress reduction, moderate alcohol consumption, and so on R , R. Below you can find some tips to improve your biological age we have much more tips on this page :. We compiled 60 tips to slow down and even partially reverse aging here. These and other studies show that aging can be reversed. And not just aging, but also various aging-related diseases at the same time. For example, if people adhere to a very healthy diet, many cases of type 2 diabetes can be reversed , and even atherosclerosis. In one study, people who adhered to a more healthy diet, and had to exercise could reduce the atherosclerotic plaque in the coronary arteries of their heart, not needing a heart operation anymore which they were recommended to undergo R. And even despite these impressive results, these study interventions read: diets can be further improved upon. Our foundational formulation, NOVOS Core, targets all the root causes of aging to promote longevity, appearance, cognition, and energy. Slow down aging with these 12 highly-effective longevity ingredients in one daily dose, which you can mix with water to drink. Each box contains 30 packets for a one-month supply. NOVOS Boost is your best NMN supplement, containing high-quality, high-purity NMN which is 3rd party tested. NOVOS' team consists of the brightest minds in the longevity field. Track your pace of aging and learn about the impacts of lifestyle changes. Includes comprehensive guidance on how to improve your scores with lifestyle upgrades. NOVOS initiated a case study from February to August For the study, 12 participants were provided with an epigenetic test kit the same test behind NOVOS Age , plus […]. Give the gift of longevity! With NOVOS longevity solutions, you can help your loved ones unlock their vitality and slow down aging through science — all with the help of a simple daily routine. You will need more water than normal if you live in a humid, hot environment, are physically active, or have a bout of illness that causes diarrhea and vomiting. Alcohol dehydrates your body since it increases urination. Dehydrated skin often appears dry, sallow, and dull. Cutting back on alcohol can also improve overall health. Excess alcohol intake can lead to long-term health concerns, including a weak immune system , cancer, high blood pressure, mental health problems, and more. Make sure you get at least seven to eight hours of sleep per day for a good night's rest. A lack of quality sleep can also increase your risk of a host of health problems, such as:. Avoid caffeine and exercise in the late afternoon or early evening if you have trouble sleeping. Try removing electronic devices from your bedroom, and make sure your space is quiet, dark, and relaxing. Regular physical activity has a positive effect on your brain health. Exercise helps improve your thinking, learning, and judgment skills as you age. The Centers for Disease Control and Prevention CDC advises minutes of aerobic activity per week, such as biking, jogging, running, or walking. The CDC also advises two days of muscle-strengthening activities per week. This type of exercise, which includes doing bodyweight exercises and lifting weights, strengthens your bones, joints, and muscles so you can do your daily activities. Research has shown chronic stress speeds up aging. Stress is also a risk factor for autoimmune disorders, cancer, heart disease, and neurological diseases. Here are some ways to relieve stress:. You might look down at your smartphone constantly throughout the day. Craning your neck downward and other repetitive motions cause fine lines and wrinkles. Holding your smartphone at eye level can improve your posture, which might reduce your risk of pain and injuries. Stained, yellowed teeth can increase physical attributes of aging. Remove stains with whitening toothpaste or strips to feel more confident about your smile. You can also prevent discoloration by:. Your body changes as you get older, and the process of aging is normal. It's natural for your hair to turn gray and your skin to sag and wrinkle. You cannot prevent aging, but there are different ways to slow down the process and keep yourself healthy. Get enough sleep, protect your skin with sunscreen, eat a balanced diet, exercise, and manage your stress. Aging changes in skin. National Institute on Aging. What do we know about healthy aging? American Academy of Dermatology Association. Sunscreen FAQs. Sun exposure. Skin care and aging. How to safely exfoliate at home. Grajqevci-Kotori M, Kocinaj A. Exfoliative skin-peeling, benefits from this procedure and our experience. Med Arch. Pullar JM, Carr AC, Vissers MCM. The roles of vitamin C in skin health. How to care for your skin in your 60s and 70s. Retinoid or retinol? What can make my hands look younger? Centers for Disease Control and Prevention. Health effects of cigarette smoking. Pizzino G, Irrera N, Cucinotta M, et al. Oxidative stress: Harms and benefits for human health. Oxid Med Cell Longev. Facts about polyunsaturated fats. Paul AK, Lim CL, Apu MAI, et al. Are fermented foods effective against inflammatory diseases? Int J Environ Res Public Health. After the age of 40, you can lose eight percent of muscle mass every decade, slowing your metabolism and weakening your body, so cement good habits early. Compound lifts also increase your production of testosterone, and research in the Journal Of Clinical Endocrinology And Metabolism has linked reduced testosterone to an elevated risk of heart disease. Cycling, running or other endurance training will keep you feeling young. Sitting at a desk is terrible for our posture but these exercises fight the bad habits which age you. A heavy one-rep max day or brutal CrossFit class is fine but not every session should be a pain-fest. Your exercise should be regular — 40 minutes, five days a week will cut your biological age by nine years, according to Brigham Young University — but moderate exercise is fine: a study by Appalachian State University showed that moderate-intensity resistance training is as good as hypertensive medication at lowering blood pressure. You get them from oily fish, olive oil, raw nuts, seeds and avocado. A study in the British Journal Of Nutrition suggested that changing to a Mediterranean-style diet of fish, vegetables, wholegrain and unrefined carbohydrates — even later in life — brings a 25 percent reduction in all-cause mortality. Research in the journal Neurology has also shown that following this diet helps you retain brain volume to ward off dementia and memory loss. Research by the University of Miami shows that ginger has an anti-inflammatory effect on cells, while a study in the Saudi Medical Journal suggests a daily dose can improve cholesterol levels. Curcumin, found in turmeric, also has anti-inflammatory properties, according to a report in Advances In Experimental Medicine And Biology. For an antioxidant hit, try her body-boosting green smoothie, made from three handfuls of kale, two sticks of celery, two apples, ¼ avocado, 1tsp ground flaxseeds and water. Get your eight hours. A University of California study revealed that stress is linked to shortened telomeres and higher oxidative stress — both markers that correlate to reduced longevity. Keeping a daily journal can help you achieve clarity thoughts and a sense of closure — writing always involves a beginning and an end. The process itself encourages you to find solutions. Written by Mark Bailey for Coach and legally licensed through the Matcha publisher network. Please direct all licensing questions to legal getmatcha. For acute orthopedic injuries after scheduled clinic and urgent care hours, please utilize the HURT! App, in partnership with OrthoCarolina, for fast free access to orthopedic advice with a response time of ~4 minutes.

Age-reversing strategies -

This meant their biological age was lower or higher depending on the amount of methylation in their DNA than their chronological age. Severe stress has been previously linked to higher mortality rates by increasing biological age due to increased susceptibility to stress-related diseases.

In the same way, the new study shows that reversing your biological age can decrease your mortality. The results of the study suggest that your biological age may now also be a useful measure of your stress levels and how well you have recovered.

As the study shows that our bodies are able to induce this reversal naturally, it provokes questions as to whether we might be able to reverse our age below the recovery baseline. For the study, Duke University School of Medicine provided the mice samples which were then analysed by academics from Harvard Medical School, including first author Dr Jesse Poganik.

But is the kind of bad day that gives you dark circles under your eyes enough to accelerate biological ageing as much as surgery or, say, pregnancy? It also remains unclear whether we can bring down accelerated ageing over a longer time period.

While the study did not pursue whether recovery must be active or passive, White speculates that a combination of physical and mental rest is important to recovery — and if either is lacking then the other will be limited.

Recovery is mostly a passive process, according to White, but an often-neglected aspect of recovery is the mental side which some people might need extra help with. The results also showed some variability that suggests that some people might be better at recovering than others.

The study began with a process known as heterochronic parabiosis, which involves surgically attaching pairs of young and old mice together so they share one circulation.

The infusion of young blood into the older mouse induces a reversal of its biological age — but for the young mouse, the stress of being exposed to aged blood increases its biological age.

The study found that this was temporary, and the young mouse returned to its baseline biological age after recovery. Therefore, within the constraints of comparable data on the Horvath DNAmAge clock at baseline and endpoint, no cases were omitted.

Participants followed an intervention that included a specific set of dietary recommendations high in known epinutrients. Simple carbohydrates were restricted, and the diet was largely plant centered but included key nutrient-dense animal protein from eggs per week, 6 oz of animal protein daily, and three 3-ounce servings of liver per week or an encapsulated liver supplement.

Participants were also asked to eat all food within a hour window each day to incorporate a basic level of intermittent fasting. Different from the original study, participants were encouraged to track their water consumption aiming for 8-cups of water per day.

Dietary supplements consisted of a probiotic containing 40 million CFU of Lactobacillus plantarum v. plantarum UltraFlora® Intensive Care, Metagenics Inc. Aliso Viejo, CA, USA and a fruit and vegetable powder, rich in additional polyphenolic compounds, twice a day PhytoGanix®, Metagenics Inc.

Aliso Viejo, CA, USA. Lifestyle modifications that participants were asked to incorporate included a minimum of 30 minutes of physical activity at least 5 days a week, at an intensity of percent of maximum perceived exertion.

All participants were encouraged to get a minimum of seven hours of sleep per night, participate in two, minute breathing sessions per day designed to elicit the relaxation response a meditation video was provided.

The intervention program was delivered through the beta testing of a HIPAA-compliant digital application [herein the app].

The app provided video and written instruction, daily tracking tools, optional recipes, a shopping list, and reminders for participants to complete. An overview of the intervention is shown in Table 3. Includes broccoli, cabbage, cauliflower, Brussels sprouts, bok choy, arugula, kale, mustard greens, watercress, rutabaga, kohlrabi, radish, Swiss chard, turnip.

As in the original pilot study, adherence to the program was supported by regular coaching sessions conducted by trained nutritionists, delivered weekly during the first four weeks, and then at least every other week thereafter. Nutrition coaches had a predefined list of questions that covered adherence to intervention guidelines and queried any changes to medications.

Participants had access to nutrition coaches between sessions via texting within the app, with an expected response time of hours. Biological age testing was conducted at baseline and at week 8 for all six participants by TruDiagnostc Laboratory.

To calculate the Horvath DNAmAge clock, the agep function in the wateRmelon R package was used. Beta values were normalized using the SeSAMe pipeline [a]. While it was trained against chronological age, multiple studies have shown acceleration of this clock to be associated with age-related disease risk and all-cause mortality [ 8 ].

KF and TC developed the manuscript. SM contributed to the data analysis and results reporting. RH assisted with reviewing and editing the manuscript. All authors approved the manuscript. We would like to acknowledge and thank the following for their assistance: Nutritionist coaches: Karen Herb MS CNS LDN, Amanda Turton-Huff, MS, Melissa Parker MS CNS CDN, Miranda Kusi MS CNS CDN, Olivia Moeller MS CNS, Despina Giannopoulou MS IFMCP, Sally Logan MS CNS CKNS, Melissa Twedt MS CNS LDN, Rachel Suprenant, ND IFMCP, Darisa Espinal ND, MS and Josette Herdell MS CNS LDN.

Suggestic staff: Victor Chapela, Shai Rozen, Erica Sanders and Ives Laurent. TruDiagnostic staff: Ryan Smith and Varun Dwaraka PHD. The authors declare that they have no conflicts of interest. Kara Fitzgerald is the owner of a patent application for the intervention used in this study.

Kara N. Fitzgerald kf drkarafitzgerald. Navigate Home Editorial Board Information For Authors Advance Online Publications Current Issue Archive Scientific Integrity Publication Ethics and Publication Malpractice Statements Contact Special Collections Podcast News Room Interviews with Outstanding Authors.

Research Paper Volume 15, Issue 6 pp — Cite this Article How to cite Fitzgerald KN , Campbell T , Makarem S , Hodges R ,.

Abstract Here we report on a case series of six women who completed a methylation-supportive diet and lifestyle program designed to impact DNA methylation and measures of biological aging. Introduction Six in ten adults in the United States have at least one chronic disease and four in ten adults have two or more [ 1 ].

Retrieved The Cochrane Database of Systematic Reviews. ISSN X. Nature Medicine. Experimental Gerontology. Bibcode : Sci Journal of Aging Studies. Le Annals of the New York Academy of Sciences. Bibcode : NYASA Free Radical Biology and Medicine.

Frontiers in Behavioral Neuroscience. Enette; Heilbronn, Leonie K. Diabetes Care. Cell Stem Cell. October Trends in Biotechnology. Positive Futurist. Archived from the original on March 18, Cleveland Clinic Journal of Medicine. org: Independent Open Letter in Support of Aging Research.

April Rejuvenation Research. Outline of life extension. Anti-oxidants Anti-aging movement Biohacking Calorie restriction Cryonics Cyborg Exercise Free-radical theory Gene therapy Gerontology Glycation Indefinite lifespan Index of topics related to life extension List of aging processes Longevity escape velocity Mind uploading Nanomedicine Organ printing Rejuvenation Senescence Stem-cell therapy Strategies for engineered negligible senescence Transhumanist politics.

Timeline of senescence research. Bill Andrews Eric R. Braverman Aubrey de Grey Laura Deming Denham Harman Leonard Hayflick Saul Kent Cynthia Kenyon Dimu Kotsovsky Ray Kurzweil Ilya Mechnikov Liz Parrish Durk Pearson Mark Roth Sandy Shaw Roy Walford Michael D.

Life Extension The First Immortal Fantastic Voyage Ending Aging Lifespan: Why We Age — and Why We Don't Have To Ageing Research Reviews Aging Aging Cell Biogerontology Experimental Gerontology Neurobiology of Aging Rejuvenation Research.

Life extension. Old age Senescence aging-associated diseases degenerative diseases negligible senescence Gerontology biogerontology cognitive epidemiology Centenarian supercentenarian research into centenarians Longevity myths Life expectancy Maximum life span Biomarkers of aging.

Topic outline index Anti-aging movement Biodemography of human longevity Indefinite lifespan Longevity escape velocity Methods calorie restriction Diet and longevity gene therapy nanomedicine organ printing rejuvenation stem-cell therapy SENS.

Biological immortality Regeneration Digital immortality Agelessness Eternal youth Immortality in fiction. Longevity claims Oldest people verified by country living. FOXO3 APOE CETP ACE IL6 Klotho SIRT1 TNF. Blue zone Longevity insurance Longevity risk Transhumanist politics Longest-living organisms.

Outline of transhumanism Transhumans Transhumanism in fiction. Abolitionism Extropianism Immortalism Postgenderism Postpoliticism Singularitarianism Technogaianism.

Your Age-reversinf influences many things Non-GMO foods your life: Complications of hyperglycemia wage packet, insurance premiums, dating habits, even your Age-revversing tastes and Ave-reversing preferences. But it reveals surprisingly little about your personal Age-revwrsing, Age-reversing strategies, vulnerability to injury and illness, or cognitive function. Obvious signs of a higher health age are excess body fat or muscle wastage, which trigger a premature risk of age-related problems like heart disease and impaired physical function. Knowing your biological age can help slash this risk, by verifying if you are aging well or inspiring you to rewind the clock. Without consensus, it is impossible to have one definitive biological age test. What if strategirs wrinkles, losing your strength, and developing age-related srategies were Safe fat loss inevitable? Safe fat loss Anti-angiogenesis potential of natural compounds the gAe-reversing developments Complications of hyperglycemia the field of longevity, this may Age-reverslng the case. Aging is a complex process sttrategies Complications of hyperglycemia begin and progress at some point in your life. But research suggests you can turn back your biological age clock—how old you are internally—and by preventing and in some cases even reversing aging processes by implementing simple yet powerful lifestyle choices. Some of these changes are benign, like gray hair and wrinkles, while others can have a significant impact on our health and longevity, like reduced mobility and increased disease risk.

Video

Researchers Say They Are Close To Reversing Aging