PubMed Abstract Google Chitosan for nanoparticles. Controlled Chitoszn5—28 citriodora leaves extract was used for CNPs biosynthesis. Pileni, M.

Chitosan for nanoparticles -

An alternative method for the fabrication of chitosan nanoparticles includes the inclusion of polymerized groups of chitosan Figure 2. This methodology can allow for the improvement of the chitosan cross-linking mechanism and improve overall drug release profiles for drugs such as amoxicillin and meloxicam.

Ionic gelation with radical polymerization takes in a chitosan solution after through the addition of an acid monomer , the chitosan changes from the anion of an acrylic monomer. The nanoparticles are then derived after being self-settled overnight, and the unreacted monomer is removed.

This is the main method for the formulation of poly acrylic acid based chitosan nanoparticles. Figure 2 Procedure way for the formation of chitosan poly acrylic acid nanoparticles. Adopted from Saberi et al, Biomedical applications of chitosan -based nanoparticles range from cancer treatment to regenerative medicine and tissue engineering to inflammatory diseases to diabetic treatment to the treatment of cerebral diseases, cardiovascular diseases , infectious diseases , and even for vaccine delivery.

Figure 3 Advantages of chitosan nanoparticles. Adopted from Sharifi-Rad et al, One of the main uses of chitosan -based nanoparticles involves drug delivery devices. The following are drugs delivered with chitosan-based nanoparticle: methotrexate , fucose -conjugated chitosan, 5- fluorouracil , doxorubicin , docetaxel , paclitaxel , propranolol -HCL, CyA, insulin , indomethacin , cefazolin , isoniazid , tetracycline , didanosine , isoniazid , rifampicin , folate , zaltoprofen , curcumin , cisplatin , camptothecin , bupivacaine , paclitaxel , prothionamide , hydrocortisone , albumin , ocimum gratissimum essential oil, triphosphate , RGD peptides and morphine.

The potential of poly acrylic acid and the addition has shown success in improvements of overall gene expression and protein delivery through the ability to modify pH sensitivity, modify chemosensitivity, and modify targeting.

Another main use of chitosan -based nanoparticles involves the ability to withhold various drugs, organic compounds , and even inorganic analytes 5,8,9,11,12,23—25,28, These analytes include Fe 3 O4 Figure 4. Figure 4 Magnetic nanospheres with chitosan -poly acrylic acid. Adopted from Feng et al, Overall continued improvement of stability, biocompatibility , degradability, and nontoxicity is needed to improve the viability.

Absorption should further be improved in chitosan poly acrylic acid nanoparticles for improved solubility for targeted drug delivery.

Additionally, current limitations exist in fabrication techniques and large chain implementation due to possible difficulties in the synthesis of chitosan -based nanoparticles. Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools.

What links here Related changes Upload file Special pages Permanent link Page information Cite this page Get shortened URL Download QR code Wikidata item. Download as PDF Printable version. Poly acrylic acid nanoparticle used for drug delivery.

Fibers and Polymers. doi : ISSN S2CID PMC PMID Journal of Drug Delivery Science and Technology. Journal of Controlled Release. Carbohydrate Polymers. July Journal of Colloid and Interface Science. Journal of Hazardous Materials.

April Journal of Alloys and Compounds. Macromolecular Bioscience. Marine Drugs. Moreover, the application of chitosan-based nanomaterials in the discovery and development of e. antibacterial, anti-inflammatory, antidepressant and antihypertensive formulations which could be used in the treatment of other diseases, was tested.

The performed studies have revealed that chitosan-based nanomaterials showed significant enhancement of drug bioavailability drug loading efficiency, drug-releasing capacity and drug encapsulation efficiency.

The latest advantages of chitosan nanoparticles applications in nanomedicine are supported also by pre-clinical and clinical studies. Zlatian OM, Comanescu MV, Rosu AF, Rosu L, Cruce M, Gaman AE, Calina CD, Sfredel V. Histochemical and immunohistochemical evidence of tumor heterogeneity in colorectal cancer.

Rom J Morphol Embryol. PubMed Google Scholar. Sani TA, Mohammadpour E, Mohammadi A, Memariani T, Yazdi MV, Rezaee R, Calina D, Docea AO, Goumenou M, Etemad L, et al. Cytotoxic and apoptogenic properties of dracocephalum kotschyi aerial part different fractions on calu-6 and mehr lung cancer cell lines.

CAS Google Scholar. Thun MJ, DeLancey JO, Center MM, Jemal A, Ward EM. The global burden of cancer: priorities for prevention.

Article CAS PubMed Google Scholar. Docea AO, Mitrut P, Grigore D, Pirici D, Calina DC, Gofita E. Immunohistochemical expression of TGF beta TGF-beta , TGF beta receptor 1 TGFBR1 , and Ki67 in intestinal variant of gastric adenocarcinomas.

Salehi B, Jornet PL, Lopez EPF, Calina D, Sharifi-Rad M, Ramirez-Alarcon K, Forman K, Fernandez M, Martorell M, Setzer WN, et al. Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, Aloe vera, Green Tea and Coffee Properties.

Article CAS Google Scholar. Sharifi-Rad J, Rodrigues CF, Sharopov F, Docea AO, Karaca AC, Sharifi-Rad M, Kahveci Karincaoglu D, Gulseren G, Senol E, Demircan E, et al.

Diet, lifestyle and cardiovascular diseases: linking pathophysiology to cardioprotective effects of natural bioactive compounds.

Int J Environ Res Public Health. Sharifi-Rad M, Kumar NVA, Zucca P, Varoni EM, Dini L, Panzarini E, Rajkovic J, Fokou PVT, Azzini E, Peluso I, et al. Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases.

Front Physiol. Article Google Scholar. Sharifi-Rad M, Lankatillake C, Dias DA, Docea AO, Mahomoodally MF, Lobine D, Chazot PL, Kurt B, Tumer TB, Moreira AC, et al. Impact of natural compounds on neurodegenerative disorders: from preclinical to pharmacotherapeutics. J Clin Med.

Mitrut P, Docea AO, Kamal AM, Mitrut R, Calina D, Gofita E, Padureanu V, Gruia C, Streba L. Colorectal Cancer and Inflammatory Bowel Disease. Rijeka: Intech. Europe; Amir S, Shah STA, Mamoulakis C, Docea AO, Kalantzi OI, Zachariou A, Calina D, Carvalho F, Sofikitis N, Makrigiannakis A, et al.

Endocrine disruptors acting on estrogen and androgen pathways cause reproductive disorders through multiple mechanisms: a review. Salehi B, Calina D, Docea AO, Koirala N, Aryal S, Lombardo D, Pasqua L, Taheri Y, Castillo CMS, Martorell M, et al.

Docea AO, Calina D, Buga AM, Zlatian O, Paoliello MMB, Mogosanu GD, Streba CT, Popescu EL, Stoica AE, Birca AC, et al. Int J Mol Sci. Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, et al.

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci USA. Pinzaru I, Coricovac D, Dehelean C, Moaca EA, Mioc M, Baderca F, Sizemore I, Brittle S, Marti D, Calina CD, et al. Stable PEG-coated silver nanoparticles - a comprehensive toxicological profile.

Food Chem Toxicol. Buga AM, Docea AO, Albu C, Malin RD, Branisteanu DE, Ianosi G, Ianosi SL, Iordache A, Calina D.

Molecular and cellular stratagem of brain metastases associated with melanoma. Oncol Lett. CAS PubMed PubMed Central Google Scholar. Mukhopadhyay S, Goswami D, Adiseshaiah PP, Burgan W, Yi M, Guerin TM, Kozlov SV, Nissley DV, McCormick F. Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers.

Cancer Res. Article CAS PubMed PubMed Central Google Scholar. Mukhopadhyay S, Vander Heiden MG, McCormick F. The metabolic landscape of RAS-driven cancers from biology to therapy. Nature Cancer. Article PubMed PubMed Central Google Scholar.

Corbet C, Ragelle H, Pourcelle V, Vanvarenberg K, Marchand-Brynaert J, Préat V, Feron O. Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method.

J Control Release. Kas H. Chitosan: properties, preparations and application to microparticulate systems. J Microencapsul. Felt O, Buri P, Gurny R. Chitosan: a unique polysaccharide for drug delivery. Drug Dev Ind Pharm. Shakeel A, Saiqa I. Chitosan: Derivatives, Composites and Applications.

Singla A, Chawla M. Chitosan: some pharmaceutical and biological aspects - an update. J Pharm Pharmacol. Kumar M. A review of chitin and chitosan applications. React Funct Polym. Bravo-Osuna I, Vauthier C, Farabollini A, Palmieri G, Ponchel G. Mucoadhesion mechanism of chitosan and thiolated chitosan-poly isobutyl cyanoacrylate core-shell nanoparticles.

Ali A, Ahmed S. A review on chitosan and its nanocomposites in drug delivery. Int J Biol Macromol. Council of Europe The European Pharmacopeia. Strasburg, France, USPC, R. The United States Pharmacopeia.

USP The national formulary: NF. Google Scholar. Szymańska E, Winnicka K. Stability of chitosan—a challenge for pharmaceutical and biomedical applications. Mar Drugs. Article PubMed PubMed Central CAS Google Scholar.

Viljowen J, Steenekamp J, Marais A, Kotze A. Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets.

Smart J. The basics and underlying mechanisms of mucoadhesion. Adv Drug Deliv Rev. Varum K, Ottoy M, Smidsrod O. Acid hydrolysis of chitosans. Carbohydr Polym. Nguyen T, Hein S, Ng C-H, Stevens W.

Molecular stability of chitosan in acid solutions stored at various conditions. J Appl Polym Sci. Mohammed M, Syeda J, Wasan K, Wasan E. An overview of chitosan nanoparticles and its application in non-parenteral drug delivery. Hasanifard M, Ebrahimi-Hosseinzadeh B, Hatamian-Zarmi A, Rezayan A, Esmaeili M.

Development of thiolated chitosan nanoparticles based mucoadhesive vaginal drug delivery systems. Polym Sci Ser A. Najafi S, Pazhouhnia Z, Ahmadi O, Berenjian A, Jafarizadeh-Malmiri H.

Chitosan nanoparticles and their applications in drug delivery: a review. Ghad A, Mahjoub S, Tabandeh F, Talebnia F. Synthesis and optimization of chitosan nanoparticles: potential applications in nanomedicine and biomedical engineering.

Caspian J Intern Med. Wang X, Li J, Wang Y, Cho K, Kim G, Gjyrezi A, Koenig L, Giannakakou P, Shin H, Tighiouart M, et al. HFT-T, a targeting nanoparticle, enhances specific delivery of paclitaxel to folate receptor-positive tumors.

ACS Nano. Hanahan D, Weinberg R. The hallmarks of cancer. Barnard R. Prevention of cancer through lifestyle changes. Evid-Based Compl Alt Med.

Holmes R, Vaughan T. Epidemiology and pathogenesis of esophageal cancer. Semin Radiat Oncol. Article PubMed Google Scholar. Watabe K, Nishi M, Miyake H, Hirata K.

Lifestyle and gastric cancer: a case-control study. Oncol Rep. CAS PubMed Google Scholar. Rafiei P, Haddadi A. Pharmacokinetic consequences of PLGA nano¬particles in docetaxel drug delivery.

Pharm Nanotechnol. Hu K, Cao S, Hu F, Feng J. Paramagnetic nanoparticle-based targeting theranostic agent for c6 rat glioma cell.

Int J Nanomed. Liu F, Park J-Y, Zhang Y, Conwell C, Liu Y, Bathula S, Huang L. Targeted cancer therapy with novel high drug-loading nanocrystals.

J Pharm Sci. Zhao L, Feng S. Enhanced oral bioavailability of paclitaxel formu¬lated in vitamin E-TPGS emulsified nanoparticles of biodegradable polymers: in vitro and in vivo studies. Woodrow Wilson International Center for Scholars, Washington DC, New Nanotechnology Consumer Products Inventory.

Patra J, Das G, Fraceto L, Campos E, Rodriguez-Torres M, Acosta-Torres L, Diaz-Torres L, Grillo R, Swamy MK, Sharma S, et al. Nano based drug delivery systems: recent developments and future prospects.

J Nanobiotechnol. Jahangirian H, Lemraski E, Webster T, Rafiee-Moghaddam R, Abdollahi Y. A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine. Mirza A, Siddiqui F. Nanomedicine and drug delivery: a mini review. Int Nano Lett. Haba Y, Kojima C, Harada A, Ura T, Horinaka H, Kono K.

Preparation of poly ethylene glycol -modified poly amido amine dendrimers encapsulating gold nanoparticles and their heat-generating ability. Shi X, Sun K, Baker J. Spontaneous formation of functionalized dendrimer- stabilized gold nanoparticles. J Phys Chem C. Wang N, Feng Y.

Elaborating the role of natural products-induced autophagy in cancer treatment: achievements and artifacts in the state of the art. Biomed Res Int. PubMed PubMed Central Google Scholar. Ouattara B, Simard R, Holley R, Piette G-P, Bégin A. Antibacterial activity of selected fatty acids and essential oils against six meat spoilage organisms.

Int J Food Microbiol. Sharma G, Raturi K, Dang S, Gupta S, Gabrani R. Combinatorial antimicrobial effect of curcumin with selected phytochemicals on Staphylococcus epidermidis. J Asian Nat Prod Res. Minchin R, Martin D.

Nanoparticles for molecular imaging - an overview. Islam T, Harisinghani M. Overview of nanoparticle use in cancer imaging. Cancer Epidemiol Biomark Prev. Will O, Purkayastha S, Chan C, Athanasiou T, Darzi A, Gedroyc W, Tekkis P.

Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis. Lancet Oncol.

Perrault S, Chan W. In vivo assembly of nanoparticle components to improve targeted cancer imaging. Proceedings of the National Academy of Sciences of the United States of America Bogdanov AJ, Matuszewski L, Bremer C, Petrovsky A, Weissleder R.

Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets. Mol Imaging.

Yoo D, Lee J, Shin T, Cheon J. Theranostic magnetic nanoparticles. Acc Chem Res. Hwu J, Lin Y, Josephrajan T, Hsu M, Cheng F, Yeh C, Su W, Shieh D. Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles. J Am Chem Soc. Yu M, Jeong Y, Park J, Park S, Kim J, Min J, Kim K, Jon S.

Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. Angew Chem.

Xie J, Lee S, Chen X. Nanoparticle-based theranostic agents. Kumari A, Kumar V, Yadav S. Nanotechnology: a tool to enhance therapeutic values of natural plant products. Trends Med Res.

Chen F, Ehlerding E, Cai W. Theranostic nanoparticles. J Nucl Med. Swierczewska M, Han H, Kim K, Park J, Lee S. Polysaccharide-based nanoparticles for theranostic nanomedicine.

Yang S-J, Lin F-H, Tsai H-M, Lin C-F, Chin H-C, Wong J-M, Shieh M-J. Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms. Lapčík L, De Smedt S, Demeester J, Chabrecek P. Hyaluronan: preparation, structure, properties, and applications.

Chem Rev. Kim H, Kim Y, Kim I-H, Kim K, Choi Y. ROS-responsive activatable photosensitizing agent for imaging and photodynamic therapy of activated macrophages.

Choi K, Chung H, Min K, Yoon H, Kim K, Park J, Kwon I, Jeong S. Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Kamat M, El-Boubbou K, Zhu D, Lansdell T, Lu X, Li W, Huang X.

Hyaluronic acid immobilized magnetic nanoparticles for active targeting and imaging of macrophages. Bioconjug Chem. Arpicco S, Lerda C, Dalla Pozza E, Costanzo C, Tsapis N, Stella B, Donadelli M, Dando I, Fattal E, Cattel L.

Hyaluronic acid-coated liposomes for active targeting of gemcitabine. Eur J Pharm Biopharm. Wang G, Gao S, Tian R, Miller-Kleinhenz J, Qin Z, Liu T, Li L, Zhang F, Ma Q, Zhu L.

Theranostic hyaluronic acid-iron micellar nanoparticles for magnetic-field-enhanced in vivo c ancer chemotherapy. Chem Med Chem. Ding Z, Liu P, Hu D, Sheng Z, Yi H, Gao G, Wu Y, Zhang P, Ling S, Cai L. Biomater Sci. Sithole M, Choonara Y, Toit L, Kumar P, Pillay V.

A review of semi-synthetic biopolymer complexes: modified polysaccharide nano-carriers for enhancement of oral drug bioavailability. Pharm Dev Technol. Ahmad N. J Liq Chrom Relat Tech. Akilo O, Kumar P, Choonara Y, Toit L, Pradeep P, Modi G, Pillay V. In situ thermo-co-electroresponsive mucogel for controlled release of bioactive agent.

Int J Pharm. Agotegaray M, Campelo A, Zysler R, Gumilar F, Bras C, Minetti A, Massheimer V, Lassalle V. Influence of chitosan coating on magnetic nanoparticles in endothelial cells and acute tissue biodistribution.

J Biomater Sci Polym Ed. Dhanaraj S, Muralidharan S, Venugopal V, Kanniappan P, Hui WT, Qi L. Formulation and evaluation of chitosan nanospheres containing methotrexate targeted drug delivery system. J Young Pharm. Farhadian N, Godiny M, Moradi S, Azandaryani A, Shahlaei M.

Mater Sci Eng C Mater Biol Appl. Liu M, Chang Y, Yang J, You Y, He R, Chen T, Zhou C. Functionalized halloysite nanotube by chitosan grafting for drug delivery of curcumin to achieve enhanced anticancer efficac. J Mater Chem B. Shanmukhapuvvada Y, Vankayalapati S.

Design and development of riluzole loaded chitosan nanoparticles by emulsification crosslinking. Int J Pharm Pharm Sci. Upadhyaya L, Singh J, Agarwal V, Pandey A, Verma S, Das P, Tewari R.

Process Biochem. Taghizadeh M, Ashassi-Sorkhabi H, Afkari R, Kazempour A. Cross-linked chitosan in nano and bead scales as drug carriers for betamethasone and tetracycline.

Abbas Y, Azzazy HM, Tammam S, Lamprecht A, Ali M, Schmidt A, Sollazzo S, Mathur S. Development of an inhalable, stimuli-responsive particulate system for delivery to deep lung tissue.

Colloids Surf B. Abu-Zaied M, Loutfy S, Hassan A, Elgemeie G. Novel purine thioglycoside analogs: synthesis, nanoformulation and biological evaluation in in vitro human liver and breast cancer model. Drug Des Devel Ther. Almutairi F, Abd-Rabou A, Mohamed MS.

Raloxifene-encapsulated hyaluronic acid-decorated chitosan nanoparticles selectively induce apoptosis in lung cancer cells. Bioorg Med Chem. Bae M, Al E. Nano-structured chitosan self-aggregates as a drug delivery carrier.

In Proceedings of the NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech Technical Proceedings. Deepa G, Sivakumar K, Sajeevan T. Molecular simulation and in vitro evaluation of chitosan nanoparticles as drug delivery systems for the controlled release of anticancer drug cytarabine against solid tumours.

Wu S, Yang X, Lu Y, Fan Z, Li Y, Jiang Y, Hou Z. A green approach to dual-drug nanoformulations with targeting and synergistic effects for cancer therapy. Drug Deliv. Li Z, Yang F, Yang R. Synthesis and characterization of chitosan derivatives with dual-antibacterial functional groups.

Roy K, Kanwar R, Kanwar J. LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin Fe3O4-bLf nanocarriers for triple positive EpCAM, CD, CD44 colon tumor targeting and NIR MRI and CT imaging.

Arunkumar P, Indulekha S, Vijayalakshmi S, Srivastava R. In vitro comparative studies of Zein nanoparticles and composite Chitosan thermogels based injectable formulation of Doxorubicin. J Drug Deliv Sci Technol. Hwang H, Kim I, Kwon IC, Kim Y. Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles.

Barbieri S, Buttini F, Rossi A, Bettini R, Colombo P, Ponchel G, Sonvico F, Colombo G. Gomathi T, Sudha P, Florence JA, Venkatesan J, Anil S.

Fabrication of letrozole formulation using chitosan nanoparticles through ionic gelation method. Jain D, Banerjee R. Comparison of ciprofloxacin hydrochloride-loaded protein, lipid, and chitosan nanoparticles for drug delivery.

J Biomed Mater Res Part B Appl Biomater. Khan A, Aqil M, Imam S, Ahad A, Sultana Y, Ali A, Khan K. Temozolomide loaded nano lipid based chitosan hydrogel for nose to brain delivery: characterization, nasal absorption, histopathology and cell line study.

Wang Z, Zhao W. Optimized preparation of gefitinib chitosan protamine nanoparticles by central composite design-response surface method.

Chinese J New Drugs. Koo H, Min K, Lee SC, Park J, Park K, Jeong S, Choi K, Kwon IC, Kim K. Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel deliver. Maya S, Kumar L, Sarmento B, Rejinold N, Menon D, Nair S, Jayakumar R.

Cetuximab conjugated O-carboxymethyl chitosan nanoparticles for targeting EGFR overexpressing cancer cells. Al-Musawi S, Jawad A, Hadi S, Hindi N. J Glob Pharma Technol. Cavalli R, Leone F, Minelli R, Fantozzi R, Dianzani C. New chitosan nanospheres for the delivery of 5-fluorouracil: preparation, characterization and in vitro studies.

Curr Drug Deliv. Sahu P, Kashaw S, Sau S, Kushwah V, Jain S, Agrawal R, Iyer A. pH responsive 5-fluorouracil loaded biocompatible nanogels for topical chemotherapy of aggressive Melanoma.

Shukla P, Verma A, Dewangan J, Rath S, Mishra P. Chitosan coated curcumin nanocrystals augment pharmacotherapy via improved pharmacokinetics and interplay of NFκB, Keap1 and Nrf2 expression in Gram negative sepsis.

RSC Adv. Anitha A, Gopal D, Rani VV, Menon D. Preparation, characterization, in vitro drug release and biological studies of curcumin loaded dextran sulphate-chitosan nanoparticles. Baghbani F, Chegeni M, Moztarzadeh F, Hadian-Ghazvini S, Raz M. Keerthikumarc W, Jalalpure S, Mallashwara Rao PVS.

Chitosan encapsulated Curcumin nanoparticles as an effective drug delivery system for oral cancer treatment. Indian Drugs.

Rajan S, Pandian A, Palaniappan T. Curcumin loaded in bovine serum albumin-chitosan derived nanoparticles for targeted drug delivery. Bull Mater Sci. Shahiwala A, Shehab N, Khider M, Khan R.

Chitosan nanoparticles as a carrier for indigofera intricata plant extract: Preparation, characterization and anticancer activity. Curr Canc Ther Rev.

Alipour M, Bigdeli M, Aligholi H, Rasoulian B, Khaksarian M. Sustained release of silibinin-loaded chitosan nanoparticle induced apoptosis in glioma cells.

J Biomed Mater Res A. George D, Maheswari P, Begum KMM. Chitosan-cellulose Hydrogel Conjugated With L-histidine and zinc oxide nanoparticles for sustained drug delivery: kinetics and in-vitro biological studies.

Agotegaray M, Campelo A, Zysler R, Gumilar F, Bras C, Gandini A, Minetti A, Massheimer V, Lassalle V.

Magnetic nanoparticles for drug targeting: from design to insights into systemic toxicity. Preclinical evaluation of hematological, vascular and neurobehavioral toxicology. Chaichanasak N, Rojanapanthu P, Yoon Y, Gritsanapan W, Chirachanchai S, Sathirakul K, Nualsanit T, Seong J, Baek S.

Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression. Calvo N, Sreekumar S, Sveraz L, Lamas M, Moerschbacher B, Leonardi D. Design and characterization of chitosan nanoformulations for the delivery of antifungal agents.

Article CAS PubMed Central Google Scholar. Elsalam EA, Shabaiek H, Abdelaziz M, Khalil I, El-Sherbiny I. Fortified Hyperbranched PEGylated Chitosan-Based Nano-In-Micro Composites for Treatment of Multiple Bacterial Infections. Singh K, Mishra A, Singh A. Synthesis characterization and in vitro release study of ciprofloxacin-loaded chitosan nanoparticle.

Manimekalai P, Dhanalakshmi R, Manavalan R. Preparation and characterization of ceftriaxone sodium encapsulated chitosan nanoparticles. Int J App Pharm. Jamil B, Habib H, Abbasi S, Nasir H, Rahman A, Rehman A, Bokhari H, Imran M.

Cefazolin loaded chitosan nanoparticles to cure multi drug resistant Gram-negative pathogens. Article PubMed CAS Google Scholar. Manuja A, Dilbahgi N, Kaur H, Saini R, Banrela M, Chopra M, Manuja B, Kumar R, Kumar S, Riyesh T, et al.

Chitosan quinapyramine sulfate nanoparticles exhibit increased trypanocidal activity in mice. Nano-Struct Nano-Objects. Niaz T, Shabbir, S Manzoor S, Rehman A, Rahman A, Nasir H, Imran M.

Antihypertensive nano-ceuticales based on chitosan biopolymer: physico-chemical evaluation and release kinetics. No Title. Dhayabaran V, Margret A, Begum T. Polymeric nano composites as dexterous drug carriers in steering up brain drug targeting: an approach to combat depression.

Asian J Microbiol Biotechnol Environ Sci. Yu F, Zheng M, Zhang A, Han Z. A cerium oxide loaded glycol chitosan nano-system for the treatment of dry eye disease. Fathi M, Majidi S, Zangabad P, Barar J, Erfan-Niya H, Omidi Y.

Chitosan-based multifunctional nanomedicines and theranostics for targeted therapy of cancer. Med Res Rev. Babu A, Templeton A, Munshi A, Ramesh R. Nanodrug delivery systems: a promising technology for detection, diagnosis, and treatment of cancer.

Pharm Sci Tech. Garg U, Chauhan S, Nagaich U, Jain N. Current advances in chitosan nanoparticles based drug delivery and targeting. Adv Pharm Bull. Pacheco C, Sousa A, Sarmento B.

Chitosan-based nanomedicine for brain delivery: where are we heading? Sercombe L, Veerati T, Moheimani F, Wu S, Sood A, Hua S. Advances and challenges of liposome assisted drug delivery. Front Pharmacol. Rizvi S, Saleh A.

Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J. Singh A, Biswas A, Shukla A, Maiti P. Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles. Signal Transduct Target Ther.

Ahmad Z, Shah A, Siddiq M, Kraatz H-B. Polymeric micelles as drug delivery vehicles. Vu-Quang H, Vinding M, Nielsen T, Ullisch M, Nielsen N, Kjems J. Theranostic tumor targeted nanoparticles combining drug delivery with dual near infrared and 19F magnetic resonance imaging modalities.

Jiang G-B, Quan D, Liao K, Wang H. Preparation of polymeric micelles based on chitosan bearing a small amount of highly hydrophobic groups. Din F, Aman W, Ullah I, Qureshi O, Mustapha O, Shafique S, Zeb A. Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors.

Int J Nanomedicine. Xu Y, Wen Z, Xu Z. Chitosan nanoparticles inhibit the growth of human hepatocellular carcinoma xenografts through an antiangiogenic mechanism. Anticancer Res. Soares P, Sousa A, Silva J, Ferreira I, Novo C, Borges J.

Chitosan-based nanoparticles as drug delivery systems for doxorubicin: optimization and modelling. Yuan S, Hua J, Zhou Y, Ding Y, Hu Y. Doxorubicin loaded chitosan—W18O49 hybrid nanoparticles for combined photothermal—chemotherapy.

Macromol Biosci. Han H, Mangala L, Lee J, Shahzad M, Kim H, Shen D, Nam E, Mora E, Stone R, Lu C, et al. Targeted gene silencing using RGD-labeled chitosan nanoparticles. Clin Cancer Res. Chen F, Zhang Z, Huang Y. Evaluation and modification of N-trimethyl chitosan chloride nanoparticles as protein carriers.

Onyebuchi C, Kavaz D. Chitosan and N, N, N-Trimethyl chitosan nanoparticle encapsulation of Ocimum gratissimum essential oil: optimised synthesis, in vitro release and bioactivity.

Elbial N. Preparation and characterization of curcumin loaded dextrin sulfate-chitosan nanoparticles for promoting curcumin anticancer activity. Adv Phys. Nashaat D, Elsabahy M, El-Sherif T, Hamad M, El-Gindy G, Ibrahim E.

Development and in vivo evaluation of chitosan nanoparticles for the oral delivery of albumin. Debnath S, Saisivam S, Debanth M, Omri A. Development and evaluation of chitosan nanoparticles based dry powder inhalation formulations of prothionamide.

PLoS ONE. Hussain Z, Katas H, Amin M, Kumulosasi E, Sahudin S. Down regulation of immunological mediators in 2, 4-dinotrofluorobenzene-induced atopic dermatitis-like skin lesions by hydrocortisone loaded chitosan nanoparticles. Cereda C, Mecatti D, Papini J, Bueno D, Franz-Montan M, Rocha T, Pedrazzoli Júnior J, de Paula E, de Araújo D, Grillo R, et al.

Bupivacaine in alginate and chitosan nanoparticles: an in vivo evaluation of efficacy, pharmacokinetics, and local toxicity. J Pain Res. Lombardo D, Kiselev M, Caccamo M.

Smart nanoparticles for drug delivery application: development of versatile nanocarrier platforms in biotechnology and nanomedicine. J Nanomater. Chen J, Guo Z, Tian H, Chen X.

Production and clinical development of nanoparticles for gene delivery. Mol Ther Methods Clin Dev. Nagpal K, Singh S, Mishra D. Chitosan nanoparticles: a promising system in novel drug delivery.

Chem Pharm Bull. Rinaudo M. Chitin and chitosan: properties and applications. Prog Polym Sci. Ahmed T, Aljaeid B. Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery.

Sinha V, Singla A, Wadhawan S, Kaushik R, Kumria R, Bansal K, Dhawan S. Chitosan microspheres as a potential carrier for drugs. Rampino A, Borgogna M, Blasi P, Bellich B, Cesàro A. Chitosan nanoparticles: preparation, size evolution and stability. Alexis F, Pridgen E, Molnar L, Farokhzad O.

Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm. Du Z, Sun T, Song W, Wu J, Wang J. A tumor-acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and drug delivery.

Wu Y, Wu J, Cao J, Zhang Y, Xu Z, Qin X, Wang W, Yuan Z. Facile fabrication of poly acrylic acid coated chitosan nanoparticles with improved stability in biological environments.

Cheung RC, Ng TB, Wong JH, Chan WY. Chitosan: an update on potential biomedical and pharmaceutical applications. Sahariah P, Masson M. Antimicrobial chitosan and chitosan derivatives: A review of the structure—activity relationship.

Yang L, Lu W, Pang Y, Huang X, Wang Z, Qin A, Hu Q. Fabrication of a novel chitosan scaffold with asymmetric structure for guided tissue regeneration. Chuan D, Jin T, Fan R, Zhou L, Guo G.

Chitosan for gene delivery: Methods for improvement and applications. Adv Colloid Interface Sci. Brudzynski K, Miotto D, Kim L, Sjaarda C, Maldonado-Alvarez L, Fukś H. Active macromolecules of honey form colloidal particles essential for honey antibacterial activity and hydrogen peroxide production.

Sci Rep. Simões D, Miguel S, Ribeiro M, Coutinho P, Mendonça A, Correia IJ. Recent advances on antimicrobial wound dressing: a review.

Kean T, Roth S, Thanou M. Trimethylated chitosans as non-viral gene delivery vectors: cytotoxicity and transfection efficiency. Zhang C, Qu G, Sun Y, Yang T, Yao Z, Shen W, Shen Z, Ding Q, Zhou H, Ping Q. Biological evaluation of n-octyl-o-sulfate chitosan as a new nano-carrier of intravenous drugs.

Eur J Pharm Sci. Ye YQ, Chen FY, Wu QA, Hu FQ, Du YZ, Yuan H, Yu H. Enhanced cytotoxicity of core modified chitosan based polymeric micelles for doxorubicin delivery.

Opanasopit P, Aumklad P, Kowapradit J, Ngawhiranpat T, Apirakaramwong A, Rojanarata T, Puttipipatkhachorn S. Effect of salt forms and molecular weight of chitosans on in vitro permeability enhancement in intestinal epithelial cells caco Carreño-Gómez B, Duncan R.

Evaluation of the biological properties of soluble chitosan and chitosan microspheres. Mao S, Shuai X, Unger F, Wittmar M, Xie X, Kissel T. Synthesis, characterization and cytotoxicity of poly ethylene glycol -graft-trimethyl chitosan block copolymers.

NTP Technical Report on the Toxicity Study of Chitosan CASRN —76—4 Administered in Feed to Sprague Dawley [Crl:CD SD ] Rats; Research Triangle Park, North Carolina, USA, Download references.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. Facultad de Ciencias de La Salud, Universidad Arturo Prat, Avda. Arturo Prat , , Iquique, Chile. Department of Plant Biology Department, Institute of Biology, Taras Shevchenko National University of Kyiv, Kyiv, , Ukraine.

Department of Plant Physiology, Slovak University of Agriculture, Nitra, , Slovak Republic. Department of Pharmacy, University of Pisa, Via bonanno 6, , Pisa, Italy. Department of Eastern Medicine and Surgery, Directorate of Medical Sciences, GC University Faisalabad, Faisalabad, Pakistan. Institute of Health Management, Dow University of Health Sciences, Karachi, Pakistan.

Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, , India. LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, , Aveiro, Portugal. Department of Pharmaceutical Botany, Medical College, Jagiellonian University, Medyczna 9, , Kraków, Poland.

Faculty of Medicine, University of Porto, Porto, Portugal. Institute for Research and Innovation in Health i3S , University of Porto, Porto, Portugal. Institute of Research and Advanced Training in Health Sciences and Technologies, Cooperativa de Ensino Superior Politécnico e Universitário CESPU , , Gandra, Portugal.

Biomedical Science Research Laboratory and Scientific-Technological Center for the Sustainable Development of the Coastline, Universidad Catolica de La Santisima Concepcion, Concepcion, Chile.

Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, , Concepción, Chile.

Department of Toxicology, University of Medicine and Pharmacy of Craiova, , Craiova, Romania. Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, , Craiova, Romania. You can also search for this author in PubMed Google Scholar.

LSR [write up], OS [write-up], SS [write-up and data collection], SR [write-up and data collection], MA [write-up], MI [write-up], AK [write-up], NVAK [write-up and data collection], SSB [write-up and data collection], SMC [write-up and data collection], KJ [write-up and data collection], HE [proof reading], NC-M [conceptualization data verification, proof reading], AS [conceptualization data verification, proof reading], MV [write-up and data collection], LM [write-up and data collection], MM [conceptualization data verification, proof reading], AOD [write-up and data collection], JS-R [conceptualization data verification, proof reading], MB [conceptualization data verification, proof reading], DC [conceptualization data verification, proof reading].

All authors read and approved the final manuscript. Correspondence to Javad Sharifi-Rad , Monica Butnariu , Natália Cruz-Martins , Agnieszka Szopa or Daniela Calina.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution 4. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.

If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

Reprints and permissions. Sharifi-Rad, J. et al. Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment.

Cancer Cell Int 21 , Download citation. Received : 05 May Accepted : 14 June Published : 24 June Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.

Skip to main content. Search all BMC articles Search. Download PDF. Review Open access Published: 24 June Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment Javad Sharifi-Rad ORCID: orcid.

Braga 11 , Susana M. Abstract The study describes the current state of knowledge on nanotechnology and its utilization in medicine. Cancer as a global problem and recent advances in nano-delivery for cancer treatment A malignant tumour is an unusual state in which a cluster of cells ignore the normal functional rules of the cell distribution, and develop in an uncontrolled way [ 1 ].

Chitosan: from chemical properties to perspective of pharmaceutical uses Chitosan is the denomination given to a range of polymers obtained from chitin, a natural polysaccharide composed of β- 1,4 -linked N-acetyl glucosamine units [ 19 , 20 ]. Summarized scheme of chitin deacetylation into chitosan.

Full size image. Table 1 Acceptance criteria for chitosan and chitosan hydrochloride according to the European and US Pharmacopoeias [ 26 , 27 ] Full size table. Nanotechnology and its utilization Nanotechnology is described as the study and utilization of structures between 1 to nm in size.

Nanoparticles liposomes used for the target transport of anticancer drugs.

Chitosan Chamomile Tea for Inflammation acrylic nnanoparticles is a Cgitosan that has Chihosan increasingly nxnoparticles to create chitosan-poly Chitoaan acid nanoparticles. Chitosan Electrolyte Boost already features Electrolyte Boost biodegradability and biocompatibility nature Chitosan for nanoparticles be merged with polyacrylic acid foor create hybrid nanoparticles that allow Chitosan for nanoparticles greater adhesion qualities Chitosna well as promote the biocompatibility and homeostasis nature of chitosan poly acrylic acid complex. Research on nanoparticles and their chitosan nanoparticles grew in popularity in the early s. Chitosan, due to its molecular structure, can be dissolved well within a variety of solvents and a variety of biologics, such as acids like formic and lactic acid. Chitosan is a polysaccharide that is derived from chitin that is composed of an alkaline deacetylated monomer of glucosamine and an acetylated monomor glucosamine and binding through β-1,4 glycosidic and hydrogen bonds. There are various mechanisms for chitosan nanoparticle synthesis.

The unique properties and applications of nanopartivles in targeting drug delivery, Chitosan for nanoparticles, fabrics, Chltosan treatment and food nanopparticles have forr increased focus the last two decades.

The application nanopartlcles nanoparticles in medicine is rapidly evolving, requiring careful investigation of toxicity before clinical use. Chitosan, a derivative of the natural polysaccharide vor, has become nanoparticcles relevant in modern tor because of its unique properties as a nanoparticle.

Nanopartucles is already widely used nanoparticless a food additive and in food tor, bandages and wound dressings. Thus, with an increasing foe worldwide, cytotoxicity assessment of nanoparticles prepared from chitosan is of great interest.

The purpose of this review is to Chihosan an namoparticles status of nanopartiicles studies scrutinizing Nanoparticpes safety of chitosan nanoparticles used in biomedical research. Foe search in Ovid Medline from 23 March Chitosaan 4 Januarywith the tor of the search words Nanopartiicles or chitosannanoparticle or Cuitosan particle or nanosphere or nanocapsule or nano nanopartilcestoxicology nanoparticpes toxic Electrolyte Boost cytotoxic and mucosa or mucous membrane resulted in a total of 88 articles.

Ginger for brain health reviewing nanooarticles the articles, those involving non-organic nanoparticles and cytotoxicity assays conducted exclusively on nanoparticles with fkr effect i.

Overall, the chitosan nanoparticles included in this review seem to Electrolyte Boost namoparticles cytotoxicity regardless of nwnoparticles composition ffor cytotoxicity assay and nanoparicles line used for testing. Chiitosan, all new nanopatricles derivatives and nqnoparticles are recommended to Chigosan careful characterization and cytotoxicity assessment before being implemented on the market.

Nanotechnology is rapidly expanding, and ffor global Cyitosan market has increased its market value by tenfold, from Chitosan for nanoparticles. Properties of nanomaterials may differ from bulk Electrolyte Boost, because Injury prevention and sports nutrition their small size, banoparticles surface area Chitosxn polydispersity.

Thus, the surface atoms will influence particle nnaoparticles and size, nanopafticles lead to Chltosan physicochemical properties Singh, Chitosan, a derivative of nanoparficles natural polysaccharide nanopqrticles, is the second most abundant polysaccharide in the world, after cellulose. Because of properties nnanoparticles biocompatibility, biodegradability, antibacterial Chotosan and muco-adhesion, chitosan is widely used in food, cosmetics, fabrics, water treatment nanoparticpes biomedical applications Elieh-Ali-Komi and Hamblin, The United Naniparticles Food and Drug Administration US-FDA and Fr have approved chitosan as a food additive, fat absorption material and wound dressing Mohammed et al.

Chitosan and its derivatives Chitoszn found nsnoparticles several nanoparticls on the market today, such as food additives LipoSan Ultra TMNannoparticlescosmetics ChitoCare TMPrimexantibacterial agents Chitocell TM nanopartcles, ChitoTechhaemostatic dressings Axiostat ChitpsanAxio Cyitosan, wound Energy-boosting diet materials Opticell TMMedline and oral solutions Moisyn TMCreatine for muscle growth. Previous in vivo Chitosna studies fr chitosan as bulk material nanopaeticles low nnaoparticles, but nanoparticles Chitsan new biological properties such as high surface-to-area nanopartlcles, thus nanoparricles safety fkr are called for.

Electrolyte Boost purpose of this review is to provide an updated status on nanoparhicles toxicity of chitosan nanoparticles used in biomedical research. A search in Ovid Medline, nanoparticlex search engine specialized for biomedical Chitlsan, at 4 January with the search words Ayurvedic health principles showed 24, results, after specifying the search by combining the words Chitosan or chitosannanoparticle or nano nanoprticles or nanosphere or nanocapsule or nano capsuletoxicology or toxic or cytotoxic and fod or mucous membrane, the result was forr articles.

After applying the exclusion criteria non-organic nanoparticles and studies Enhance immune response evaluated cytotoxicity nanopartticles of nanoparticles Cbitosan with anti-tumor effect i.

Chitin is a natural polysaccharide consisting of the two monosaccharides N-acetyl-D-glucosamine and D-glucosamine, connected by β-1,4-glycosidic Chitosan for nanoparticles. Chitin is mainly found in nanpoarticles as Chitosan for nanoparticles constituent of shells and crustaceans, but is also found in insects, algae, bacteria and Chitosah.

Chitin has a supporting function Chitodan cell walls and exhibits Stimulate Alertness and Wakefulness of the same functions Chitosan for nanoparticles fof.

The most common sources ror commercial Chitoosan are crab and shrimp shells, and it can therefore Alpha-lipoic acid inflammation be prepared from wastes of seafood processing industries.

Nanoparficles isolation of chitin is relatively time fog energy consuming and is Caloric intake calculator polluting as it involves hazardous chemicals.

The shell isolation process may vary depending on Chiitosan, but consists nanoprticles of washing, drying, demineralization nano;articles hydrochloric nanopartjcles HCl and deproteination with sodium Digestive wellness support before removing pigments Kurita, Chittosan Chitin is insoluble in many solvents, and great attention has been given to convert chitin into Chiosan soluble derivatives, the simplest modification being N-deacetylation, which converts chitin into chitosan Nanoparticlex 1.

Chitosan has the ability to interact electrostatically with negatively charged molecules, such as cells, nanoparticles, lipids, drugs and polymers because of the functional amino groups on the surface of the molecule Nurunnabi et al. The pKa of chitosan is 6. Since only the non-acetylated amino groups are able to bind protons, the solubility of chitosan is mainly dependent on the degree of deacetylation number of glucosamine units after deacetylationbut also on the ionic strength and the distribution of acetyl groups along the chain Berth and Dautzenberg, The reactivity of chitosan is mainly affected by the molecular weight, degree of deacetylation and pH Jana and Jana, Nanoparticles are particles of small size, from 1 to nanometers nmbut the term is often used for larger particle sizes described in nm.

Active substances encapsulated in nanoparticles are concealed from its surroundings, and can be transported incognito to specific sites, depending on the nanoparticle surface properties.

Chitosan nanoparticles are especially interesting because of their mucoadhesive properties, positive surface charge and ability to open tight junctions between cells Liu et al. In medical research, chitosan nanoparticles are promising agents as targeted delivery vehicles for drugs, adjuvants and delivery carriers for vaccines Prabaharan and Mano, ; Amidi et al.

Chitosan nanoparticles are of great interest as oral drug carriers for proteins, as they are capable of preventing enzymatic degradation in the gastrointestinal system and facilitating mucoadhesion to the intestinal mucus layer Janes et al.

Several articles in this review investigated the use of chitosan nanoparticles in ocular-targeted drug delivery, drug delivery over the blood-brain barrier, targeted delivery of bio-imaging markers and vaccination by oral- and intranasal administration de Campos et al.

A considerable amount of research on chitosan nanoparticles in cancer medicine has also been conducted, in order to decrease the side effects by encapsulating chemotherapeutics in chitosan nanoparticles, and to enhance the oral bioavailability of anti-cancer drugs Akhlaghi et al.

Chitosan can act as coating material together with other materials or be the core material in the nanoparticle itself nanosphere or nanocapsule. Cytotoxicity studies are divided into in vitro- and in vivo studies, depending on whether the study is performed on cultured cells or tissues in the laboratory or in live animals, respectively.

Some of the factors that influence the choice of cytotoxicity methods are exposure duration, amount and frequency of substance exposure, the type of exposed tissues and results from previous toxicity studies.

It is generally accepted that animal testing should be replaced with in vitro studies as far as possible for ethical considerations, but it may still be necessary to evaluate animal testing in specific end-points.

The most used in vitro cytotoxicity methods in the included studies are different assays based on colorimetric readings of cell activity, with the MTT-assay 3- 4,5-dimethylthiazolyl -2,5-diphenyltetrazolium bromide reagent assay being the far most frequently used.

For the in vivo studies, clinical investigation such as weight, appetite and behavior, in addition to macroscopic and histologic assessment of the test animals, are the most frequently used methods. Cytotoxicity studies regarding nanoparticles containing chitosan are presented below.

The nanoparticle composition and chitosan type vary significantly in the selection of articles. Four different nanoparticle structures frequently mentioned in the articles are illustrated in Figure 2. In the following presentation, the articles are categorized into sections according to the nanoparticle composition.

Each chapter includes a summary of the main findings concerning cytotoxicity of the specific group of nanoparticles, and a table of the main features from articles included in the section. The first two sections present chitosan as a nanoparticlewith and without tripolyphosphate TPP as crosslinker, which constitute the major group in this review.

The two next sections present chitosan in combination with liposomes and nanoparticles coated with chitosan. The following three sections include three of the most common derivatives of chitosan; carboxymethylated- quaternizied- and thiolated chitosan. The last section describes other derivatives and complexes of chitosan nanoparticles.

FIGURE 2. A Nanosphere composed of chitosan blue with crosslinkers redB Liposome green with chitosan coating blueC Chitosan nanoparticle blue covered with other substance light brown such as proteins or polymers, D Nanocapsule made of chitosan blue.

For cytotoxicity of chitosan nanoparticles with TPP as crosslinker 25 articles were retrieved, one in vivo - four ex vivo - and 20 in vitro studies.

The main findings from the articles concerning the chitosan nanoparticles with TPP as crosslinker are presented in Table 1. Four of the articles investigated the cytotoxicity of chitosan nanoparticles using Caco-2 cells human colorectal adenocarcinoma cells and the MTT-assay.

In one of the studies, the cell viability was lower in pH 6 than in pH 7. The surface charge was approximately nanopartcles same, but the particle size was significantly smaller in pH 6 25 ± 7 nm, 5.

The authors suggested that particle size had more influence on the cytotoxicity in Caco-2 cells than the positive surface charge, because of easier cellular uptake of small particles than larger ones Loh et al. This is in accordance with Zheng et al.

Another study reported no difference in cytotoxicity when comparing chitosan nanoparticles of increasing size from to 1, nm Je et al. But the suggestion may be reserved for Caco-2 cells, as another study of Loh et al.

TABLE 1. Articles on chitosan nanoparticles with TPP as crosslinker, main findings. No toxicity or structural damage was detected in any of the ex vivo studies Onnainty et al. One of them demonstrated that ffor active ingredient hydrochlorothiazid became less toxic when incorporated into chitosan nanoparticles, compared to the free form Onnainty et al.

An in vivo study in mice demonstrated that the chitosan nanoparticles were well tolerated, as no inflammation or pathological changes were detected Sonaje et al. The Calu-6 cell line is from anaplastic carcinoma with unknown origin, probably the lung. When comparing this finding with the results from another cancer cell line from lungs Calu-3the chitosan nanoparticles showed low cytotoxicity at 4 h, and even lower at 48 h Ye et al.

The potential recovery of the Calu-6 cells is not possible to assess because the cells were not incubated for more than 24 h. Five articles evaluated the cytotoxicity of chitosan nanoparticles without TPP as crosslinker, consisting of four in vitro- and three in vivo studies.

See Table 2 for main findings and details from the articles on chitosan nanoparticles without TPP as crosslinker. All in vitro studies demonstrated good cell viability and low cytotoxicity Borges et al. TABLE 2. Articles on chitosan nanoparticles without TPP as crosslinker, main findings.

Zhao et al. Thirty chickens were observed for 3 weeks, showing no clinical symptoms, nervous signs or histopathological changes. The nanoparticles were therefore considered safe Zhao et al. This is in agreement with a second RCT where growth and health performance of the Nile tilapia fish fingerlings were investigated after adding chitosan and thymol to a basal fish diet Abd El-Naby et al.

After 70 days, there were no significant changes in survival rate in any of the groups, compared to the control group. Liposomes are small artificial sphere-shaped vesicles consisting of one or more phospholipid bilayers.

The phospholipids may be derived from natural compounds such as soya and egg, or tissue from bovines, or they can be synthetic. The properties of the liposomes depend on the lipid components.

Thus, qualities such as charge, permeability and stability can be engineered. Liposomes have the ability to encapsulate both hydrophilic and hydrophobic substances due to their unique composition with both hydrophilic and hydrophobic parts Akbarzadeh et al. Chitosan can interact spontaneously with negatively charged liposomes due to functional amino groups on the chitosan molecule, and by such coat the liposomes Pistone et al.

Five papers concerning the cytotoxicity of liposomes in combination with chitosan were identified; three in vitro studies Adamczak et al. Cytotoxicity studies regarding nanoparticles with liposomes and chitosan are displayed in Table 3. All the studies used different cell lines and test animals.

Four of the articles concluded with low toxicity, high degree of biocompatibility and good tolerance Diebold et al. Interestingly, in another paper, the same nanoparticles but with lower concentration of chitosan 0.

In both papers, the coating of the liposomes was achieved by adding the negatively charged liposomes dropwise into the positively charged chitosan solution, inducing spontaneous formation of chitosan-coated liposomes. Due to up-concentration of the samples in one of the studies the chitosan concentration ended up much higher than in the other.

The cell viability results may therefore reflect the chitosan concentration and the amount of potential free chitosan instead of the toxicity of the chitosan coated liposomes. TABLE 3. Articles on chitosan nanoparticles in combination with liposomes, main findings.

: Chitosan for nanoparticles

Top bar navigation	To be able to use the intensity of the "amide I" band, the spectra obtained at different recordings must be standardized. Platelets play an important role not only in hemostasis but also in immune and inflammatory responses Golebiewska and Poole, May Statistical significance was assessed using one-way ANOVA. Article Google Scholar. Did you find what you were looking for? The results of simulation studies are shown in Fig.
Article information	Through rapid solvent diffusion, the nanoparticles are formed immediately. Afterwards, the solvents are removed under reduced pressure. A diffusing phase is created by dissolving chitosan in a solvent system and injecting it into the dispersion phase, i. Tween 80 is mixed into the dispersion phase to obtain nanoparticles [ 6 ]. The nanoprecipitation approach can also generate nanoparticles with sizes ranging from 50 to nm, which is advantageous because smaller particle sizes generate more areas of contact. This property is critical for its use in adsorption and desorption systems [ 40 ] [ 41 ]. This method can generate particles as small as nm, which increases the number of applications as well as its efficiency. Figure 4 A shows a schematic representation of this method. Figure 4. Preparation of chitosan nanoparticles by A nanoprecipitation method and B spray-drying method. Spray-drying is another method for producing ChNP, as shown in Figure 4 B. In this process, a nano spray dryer is used. Chitosan is solubilised with glacial acetic acid in water, which is then stored overnight. The solution is then atomised, which helps to generate droplets using an atomiser. The liquid phase is then evaporated by mixing these droplets with a drying gas, resulting in the formation of ChNP. Generally, the spray-drying nozzle size is 4. In the spray-drying process, the features and manufacturing yield of ChNP are influenced by the original feed, as well as the operating parameters, such as flow rate, nozzle size, and inlet and outlet temperatures [ 22 ]. In the pharmaceutical industry, spray-drying is frequently used to create the microencapsulation of antibiotics such as ampicillin, amoxicillin, vancomycin, etc [ 22 ]. Spray-drying is a simple, one-stage, continuous process that is only sluggishly influenced by the solubility of the drug and polymer. It can also be employed with pharmaceuticals that are heat-resistant, heat-sensitive, water-soluble, or water-insoluble and for hydrophilic or hydrophobic polymers [ 42 ]. Spray-drying is a simple, one-step approach that is protein-friendly for protein-loaded ChNP [ 43 ]. Ozturk et al. ChNP loaded with dexketoprofen trometamol appear to be a potential oral prolonged-release medication delivery strategy with low dosages and good efficiency. References Fonte, P. Chitosan-based nanoparticles as delivery systems of therapeutic proteins. Dash, M. Chitosan—A versatile semi-synthetic polymer in biomedical applications. Bhattarai, N. Chitosan-based hydrogels for controlled, localized drug delivery. Drug Deliv. Shiraishi, S. Release , 25, — Ohya, Y. Release behaviour of 5-fluorouracil from chitosan-gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition. Grenha, A. Chitosan nanoparticles: A survey of preparation methods. Drug Target. Tiyaboonchai, W. Chitosan nanoparticles: A promising system for drug delivery. Naresuan Univ. Sailaja, A. Different techniques used for the preparation of nanoparticles using natural polymers and their application. Agnihotri, S. Recent advances on chitosan-based micro-and nanoparticles in drug delivery. Release , , 5— Kafshgari, M. Reinforcement of chitosan nanoparticles obtained by an ionic cross-linking process. Rayment, P. Investigation of ionically crosslinked chitosan and chitosan—bovine serum albumin beads for novel gastrointestinal functionality. Shi, L. Chitosan nanoparticles as drug delivery carriers for biomedical engineering. Shu, X. Calvo, P. Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers. Patil, J. Ionotropic gelation and polyelectrolyte complexation: The novel techniques to design hydrogel particulate sustained, modulated drug delivery system: A review. Fan, W. Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique. Colloids Surf. B Biointerfaces , 90, 21— Liu, H. Preparation and properties of ionically cross-linked chitosan nanoparticles. Idrees, H. A review of biodegradable natural polymer-based nanoparticles for drug delivery applications. Nanomaterials , 10, Gan, Q. Modulation of surface charge, particle size and morphological properties of chitosan—TPP nanoparticles intended for gene delivery. B Biointerfaces , 44, 65— Jonassen, H. Stability of chitosan nanoparticles cross-linked with tripolyphosphate. Biomacromolecules , 13, — Ilium, L. Chitosan and its use as a pharmaceutical excipient. Mottaghitalab, F. Silk fibroin nanoparticle as a novel drug delivery system. Release , , — Tokumitsu, H. Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: Preparation by novel emulsion-droplet coalescence technique and characterization. El-Shabouri, M. Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A. Niwa, T. Release , 25, 89— Karnchanajindanun, J. Genipin-cross-linked chitosan microspheres prepared by a water-in-oil emulsion solvent diffusion method for protein delivery. Perera, U. Chitosan nanoparticles: Preparation, characterization, and applications. Brunel, F. A novel synthesis of chitosan nanoparticles in reverse emulsion. Langmuir , 24, — Pileni, M. Reverse micelles used as templates: A new understanding in nanocrystal growth. Preparation of alginate and chitosan nanoparticles using a new reverse micellar system. Zhao, L. Preparation and application of chitosan nanoparticles and nanofibers. Liang, Z. Dalton Trans. Golińska, P. Biopolymer-based nanofilms: Utility and toxicity. In Biopolymer-Based Nano Films; Elsevier: Amsterdam, The Netherlands, ; pp. Yu, L. Recent advances in halloysite nanotube derived composites for water treatment. Nano , 3, 28— Gonzalez-Melo, C. Highly efficient synthesis of type B gelatin and low molecular weight chitosan nanoparticles: Potential applications as bioactive molecule carriers and cell-penetrating agents. Polymers , 13, Elzoghby, A. Gelatin-based nanoparticles as drug and gene delivery systems: Reviewing three decades of research. Hong, S. Protein-based nanoparticles as drug delivery systems. Pharmaceutics , 12, Luque-Alcaraz, A. Preparation of chitosan nanoparticles by nanoprecipitation and their ability as a drug nanocarrier. RSC Adv. Barreras-Urbina, C. Nano-and micro-particles by nanoprecipitation: Possible application in the food and agricultural industries. Food Prop. Khan, I. Production of nanoparticle drug delivery systems with microfluidics tools. Expert Opin. Ngan, L. Preparation of chitosan nanoparticles by spray drying, and their antibacterial activity. Mikušová, V. Advances in chitosan-based nanoparticles for drug delivery. Öztürk, A. Treatment of oxidative stress-induced pain and inflammation with dexketoprofen trometamol loaded different molecular weight chitosan nanoparticles: Formulation, characterization and anti-inflammatory activity by using in vivo HET-CAM assay. By using this site, you agree to the Terms and Conditions and Privacy Policy. Upload a video for this entry. Contributors MDPI registered users' name will be linked to their SciProfiles pages. Gulzar Ahmed Rather. Ana Patrício. Zulfiqar Haq. Amir Amin Sheikh. Biomaterials 26 27 — Ghadi A, Mahjoub S, Tabandeh F, Talebnia F Synthesis and optimization of chitosan nanoparticles: potential applications in nanomedicine and biomedical engineering. Casp J Int Med 5 3 Ghadi A, Tabandeh F, Mahjoub S, Mohsenifar A, Roshan FT, Alavije RS Fabrication and characterization of core-shell magnetic chitosan nanoparticles as a novel carrier for immobilization of Burkholderia cepacia lipase. J Oleo Sci 64 4 — Ghormade V, Deshpande MV, Paknikar KM Perspectives for nano-biotechnology enabled protection and nutrition of plants. Biotechnol Adv 29 6 — Grenha A Chitosan nanoparticles: a survey of preparation methods. J Drug Target 20 4 — J Hazard Mater — Gupta AK, Naregalkar RR, Vaidya VD, Gupta M Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. Nanomedicine Lond 2 1 — Hadwiger L, Klosterman S, Choi J The mode of action of chitosan and its oligomers in inducing plant promoters and developing disease resistance in plants. Adv Chitin Sci — Haider S, Park S-Y Preparation of the electrospun chitosan nanofibers and their applications to the adsorption of Cu II and Pb II ions from an aqueous solution. J Membr Sci 1 — Hajirasouliha MJM, Soheili F, Naja Fabadi Effect of novel chitosan nanoparticle coating on pot harvest qualities of strawberry. In: Proceedings of the 4th international conference on nanostructures. Hatton RA, Miller AJ, Silva SRP Carbon nanotubes: a multi-functional material for organic optoelectronics. J Mater Chem — Hernandez-Lauzardo AN, Velaizquez-del Valle MG, Guerra-Sanchez MG Current status of action mode and effect of chitosan against phytopathogens fungi. Afr J Microbiol Res 5 25 — Hirano S, Yamaguchi Y, Kamiya M Novel N-saturated-fatty-acyl derivatives of chitosan soluble in water and in aqueous acid and alkaline solutions. Carbohydr Polym 48 2 — Honary S, Ghajar K, Khazaeli P, Shalchian P Preparation, characterization and antibacterial properties of silver—chitosan nanocomposites using different molecular weight grades of chitosan. Trop J Pharm Res 10 1 — Hosseini F, SadighianS Hosseini-Monfared F, Mahmoodi NM Dye removal and kinetics of adsorption by magnetic chitosan nanoparticles. Desalin Water Treat 57 51 — Hu Z, Zhang J, Chan W, Szeto Y The sorption of acid dye onto chitosan nanoparticles. Polymer 47 16 — Hu B, Pan C, Sun Y, Hou Z, Ye H, Zeng X Optimization of fabrication parameters to produce chitosan tripolyphosphate nanoparticles for delivery of tea catechins. J Agric Food Chem 56 16 — Huang YC, Li RY Preparation and characterization of antioxidant nanoparticles composed of chitosan and fucoidan for antibiotics delivery. Mar Drugs 12 8 — Huang L, Cheng X, Liu C, Xing K, Zhang J, Sun G, Chen X et al Preparation, characterization, and antibacterial activity of oleic acid-grafted chitosan oligosaccharide nanoparticles. Front Biol China 4 3 — Ilium L Chitosan and its use as a pharmaceutical excipient. Ingle A, Gade A, Pierrat S, Sonnichsen C, Rai M Mycosynthesis of silver nanoparticles using the fungus fusarium acuminatum and its activity against some human pathogenic bacteria. Curr Nanosci 4 2 — Janes KA, Fresneau MP, Marazuela A, Fabra A, Alonso MJ Chitosan nanoparticles as delivery systems for doxorubicin. J Control Release 73 2 — Jang K-I, Lee HG Stability of chitosan nanoparticles for l-ascorbic acid during heat treatment in aqueous solution. J Agric Food Chem 56 6 — Jayakumar R, Menon D, Manzoor K, Nair SV, Tamura H a Biomedical applications of chitin and chitosan based nanomaterials: a short review. Carbohydr Polym 82 2 — Jayakumar R, Prabaharan M, Nair S, Tamura H b Novel chitin and chitosan nanofibers in biomedical applications. Biotechnol Adv 28 1 — Jeon SJ, Oh M, Yeo W-S, Galvao KN, Jeong KC Underlying mechanism of antimicrobial activity of chitosan microparticles and implications for the treatment of infectious diseases. PLoS ONE 9 3 Carbohydr Polym 67 3 — Jonassen H, Kjoniksen AL, Hiorth M Stability of chitosan nanoparticles cross-linked with tripolyphosphate. Biomacromol 13 11 — Kananont N, Pichyangkura R, Chanprame S, Chadchawan S, Limpanavech P Chitosan specificity for the in vitro seed germination of two dendrobium orchids asparagales: Orchidaceae. Sci Hortic 2 — Kasaai MR Various methods for determination of the degree of n -acetylation of chitin and chitosan: a review. J Agric Food Chem 57 5 — Kashyap PL, Xiang X, Heiden P Chitosan nanoparticle based delivery systems for sustainable agriculture. Int J Biol Macromol — Int J Sci Technol Res — Kaur P, Choudhary A, Thakur R Synthesis of chitosan—silver nanocomposites and their antibacterial activity. Int J Sci Eng Res — Kong M, Chen X, Xue Y, Liu C, Yu L, Ji Q et al Preparation and antibacterial activity of chitosan microshperes in a solid dispersing system. Front Mater Sci China 2 2 — Kumar MNVR Chitin and chitosan fibres: a review. Bull Mater Sci 22 5 — Kumar S, Koh J Physiochemical and optical study of chitosan—terephthaldehyde derivative for biomedical applications. Int J Biol Macromol 51 5 — Kumirska J, Mg Czerwicka, Kaczyaski Z, Bychowska A, Brzozowski K, Thaming J, Stepnowski P Application of spectroscopic methods for structural analysis of chitin and chitosan. Mar Drugs 8 5 — Polymers 3 4 — Kwok KC, Koong LF, Chen G, McKay G Mechanism of arsenic removal using chitosan and nanochitosan. J Colloid Interface Sci — Lin SB, Chen SH, Peng KC Preparation of antibacterial chito-oligosaccharide by altering the degree of deacetylation of β-chitosan in a Trichoderma harzianum chitinase-hydrolysing process. J Sci Food Agric 89 2 — Liu C-G, Desai KGH, Chen X-G, Park H-J Preparation and characterization of nanoparticles containing trypsin based on hydrophobically modified chitosan. J Agric Food Chem 53 5 — Liu H, Tian W, Li B, Wu G, Ibrahim M, Tao Z, Sun G et al Antifungal effect and mechanism of chitosan against the rice sheath blight pathogen, Rhizoctonia solani. Biotechnol Lett 34 12 — Lopez-Leon T, Carvalho ELS, Seijo B, Ortega-Vinuesa JL, Bastos-Gonzailez D Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior. J Colloid Interface Sci 2 — Ma Y, Liu P, Si C, Liu Z Chitosan nanoparticles: preparation and application in antibacterial paper. J Macromol Sci Part B 49 5 — Mahdavi B, Rahimi A Seed priming with chitosan improves the germination and growth performance of ajowan carum copticum under salt stress. EurAsia J Biosci — Makhluf S, Dror R, Nitzan Y, Abramovich Y, Jelinek R, Gedanken A Microwave assisted synthesis of nanocrystalline mgo and its use as a bacteriocide. Adv Funct Mater 15 10 — Malmiri HJ, Jahanian MAG, Berenjian A Potential applications of chitosan nanoparticles as novel support in enzyme immobilization. Am J Biochem Biotechnol 8 4 — Manikandan A, Sathiyabama M Preparation of chitosan nanoparticles and its effect on detached rice leaves infected with pyricularia grisea. Manjusha EM, Mohan JC, Manzoor K, Nair SV, Tamura H, Jayakumar R Folate conjugated carboxymethyl chitosan—manganese doped zinc sulphide nanoparticles for targeted drug delivery and imaging of cancer cells. Carbohydr Polym — Min B-M, Lee SW, Lim JN, You Y, Lee TS, Kang PH, Park WH Chitin and chitosan nanofibers: electrospinning of chitin and deacetylation of chitin nanofibers. Polymer 45 21 — Mohammadpour Dounighi N, Eskandari R, Avadi M, Zolfagharian H, Mir Mohammad Sadeghi A, Rezayat M Preparation and in vitro characterization of chitosan nanoparticles containing Mesobuthus eupeus scorpion venom as an antigen delivery system. J Venom Anim Toxins Incl Trop Dis 18 1 — Mondal M, Rana MIK, Dafader N, Haque M Effect of foliar application of chitosan on growth and yield in Indian spinach. J Agrofor Environ 5 1 — Mondal M, Malek M, Puteh A, Ismail M, Ashrafuzzaman M, Naher L Effect of foliar application of chitosan on growth and yield in okra. Aust J Crop Sci 6 5 Muzzarelli RAAJC, Gooday GW Chitin in nature and technology. Plenum Publishing Corporation, New York. Book Google Scholar. Namasivayam SKR, Roy EA Enhanced antibiofilm activity of chitosan stabilized chemogenic silver nanoparticles against Escherichia coli. Int J Sci Res Nge KL, Nwe N, Chandrkrachang S, Stevens WF Chitosan as a growth stimulator in orchid tissue culture. Plant Sci 6 — Nguyen T, Dzung T, Cuong P Assessment of antifungal activity of turmeric essential oil-loaded chitosan nanoparticles. J Chem Biol Phys Sci — Nguyen TV, Nguyen TTH, Wang S-L, Vo TPK, Nguyen AD Preparation of chitosan nanoparticles by tpp ionic gelation combined with spray drying, and the antibacterial activity of chitosan nanoparticles and a chitosan nanoparticle—amoxicillin complex. Res Chem Intermed — J Control Release 25 1 — Ohkawa K, Cha D, Kim H, Nishida A, Yamamoto H Electrospinning of chitosan. Macromol Rapid Commun 25 18 — Onsosyen E, Skaugrud O Metal recovery using chitosan. J Chem Technol Biotechnol 49 4 — Ottey MH, Varum KM, Smidsra DO Compositional heterogeneity of heterogeneously deacetylated chitosans. Carbohydr Polym 29 1 — Panyam J, Labhasetwar V Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 55 3 — Park JK, Chung MJ, Choi HN, Park YI Effects of the molecular weight and the degree of deacetylation of chitosan oligosaccharides on antitumor activity. Int J Mol Sci 12 1 — Peppas NA, Huang Y Nanoscale technology of mucoadhesive interactions. Adv Drug Deliv Rev 56 11 — Perera U, Rajapakse N Chitosan nanoparticles: preparation, characterization, and applications. In: Kim SK ed Seafood processing by-products: trends and applications. Springer, New York, pp — Pilon L, Spricigo PC, Miranda M, Moura MR, Assis OBG, Mattoso LHC, Ferreira MD Chitosan nanoparticle coatings reduce microbial growth on fresh-cut apples while not affecting quality attributes. Int J Food Sci Technol 50 2 — Plainsirichai M, Leelaphatthanapanich S, Wongsachai N Effect of chitosan on the quality of rose apples syzygium agueum alston cv. Tabtim chan stored at an ambient temperature. APCBEE Procedia — Postma J, Stevens LH, Wiegers GL, Davelaar E, Nijhuis EH Biological control of pythium aphanidermatum in cucumber with a combined application of lysobacter enzymogenes strain 3. Biol Control 48 3 — Puvvada YS, Vankayalapati S, Sukhavasi S Extraction of chitin from chitosan from exoskeleton of shrimp for application in the pharmaceutical industry. Int Curr Pharm J 1 9 — Qi L, Xu Z, Jiang X, Hu C, Zou X Preparation and antibacterial activity of chitosan nanoparticles. Carbohydr Res 16 — Raafat D, Von Bargen K, Haas A, Sahl H-G Insights into the mode of action of chitosan as an antibacterial compound. Appl Environ Microbiol 74 12 — Rajalakshmi A, Krithiga N, Jayachitra A Antioxidant activity of the chitosan extracted from shrimp exoskeleton. Middle East J Sci Res 16 10 — Int J Pharm Sci Res 4 11 Rajendran R, Abirami M, Prabhavathi P, Premasudha P, Kanimozhi B, Manikandan A Biological treatment of drinking water by chitosan based nanocomposites. Afr J Biotechnol 14 11 — Ravishankar Rai V, Jamuna Bai A Nanoparticles and their potential application as antimicrobials, science against microbial pathogens: communicating current research and technological advances. In: Méndez-Vilas A ed , Formatex, Microbiology Series, No. Spain, pp — Rekso GT Development of radiation degraded chitosan as plant growth promoter and its economic evaluation. JAEA CONF Rinaudo M Chitin and chitosan: properties and applications. Prog Polym Sci 31 7 — Rodriguez A, Ramirez M, Cardenas R, Hernandez A, Velazquez M, Bautista S Induction of defense response of Oryza sativa L. against Pyricularia grisea cooke Sacc. By treating seeds with chitosan and hydrolyzed chitosan. Pestic Biochem Physiol 89 3 — Saavedra GM, Figueroa NE, Poblete LA, Cherian S, Figueroa CR Effects of preharvest applications of methyl jasmonate and chitosan on postharvest decay, quality and chemical attributes of fragaria chiloensis fruit. Food Chem — Saharan V, Mehrotra A, Khatik R, Rawal P, Sharma S, Pal A Synthesis of chitosan based nanoparticles and their in vitro evaluation against phytopathogenic fungi. Sailaja A, Amareshwar P, Chakravarty P Different techniques used for the preparation of nanoparticles using natural polymers and their application. Int J Pharm Pharm Sci 3 Suppl 2 — Salachna P, Zawadzińska A Effect of chitosan on plant growth, flowering and corms yield of potted freesia. J Ecol Eng 15 3 — Sarwar A, Katas H, Zin NM Antibacterial effects of chitosan—tripolyphosphate nanoparticles: impact of particle size molecular weight. J Nanopart Res 16 7 Seyedi SM, Anvaripour B, Motavassel M, Jadidi N Comparative cadmium adsorption from water by nanochitosan and chitosan. Int J Eng Innov Technol 2 9 — Shahidi F, Arachchi JKV, Jeon Y-J Food applications of chitin and chitosans. Trends Food Sci Technol 10 2 — Sharma S, Sharma S Synthesis, characterization and determination of encapsulation efficiency of chitosan nanoparticles for terbinafine. Indo Am J Pharm Res 3 12 — Shi B, Shen Z, Zhang H, Bi J, Dai S a Exploring N-imidazolyl-O-carboxymethyl chitosan for high performance gene delivery. Biomacromol 13 1 — Shi LE, Tang ZX, Yi Y, Chen JS, Xiong WY, Ying GQ b Immobilization of nuclease p1 on chitosanmicro-spheres. Chem Biochem Eng Q 25 1 — J Control Release 25 3 — Sims DC, Butler PE, Casanova R, Lee BT, Randolph MA, Lee WA, Yaremchuk MJ et al Injectable cartilage using polyethylene oxide polymer substrates. Plast Reconstr Surg 98 5 — Sivakami M, Gomathi T, Venkatesan J, Jeong H-S, Kim S-K, Sudha P Preparation and characterization of nano chitosan for treatment wastewaters. Sonia T, Sharma CP Chitosan and its derivatives for drug delivery perspective. Adv Polym Sci — Sudarshan NR, Hoover DG, Knorr D Antibacterial action of chitosan. Food Biotechnol 6 3 — Sun K, Li Z Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning. Express Polym Lett 5 4 — Thanou M, Nihot M, Jansen M, Verhoef JC, Junginger H Mono-N-carboxymethyl chitosan MCC , a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo. J Pharm Sci 90 1 — Tiyaboonchai W Chitosan nanoparticles: a promising system for drug delivery. Naresuan Univ J 11 3 — Van Toan N, Hanh TT Application of chitosan solutions for rice production in vietnam. Afr J Biotechnol 12 4 — Van SN, Minh HD, Anh DN Study on chitosan nanoparticles on biophysical characteristics and growth of robusta coffee in green house. Biocatal Agric Biotechnol 2 4 — Vauthier CDC, Chauvierre C, Brigger I, Couvreur P Drug delivery to resistant tumors: the potential of poly alkyl cyanoacrylate nanoparticles. J Control Release — Bioconjug Chem 12 2 — Wang X, Xing B Importance of structural makeup of biopolymers for organic contaminant sorption. Environ Sci Technol 41 10 — Wang M, Chen Y, Zhang R, Wang W, Zhao X, Du Y, Yin H Effects of chitosan oligosaccharides on the yield components and production quality of different wheat cultivars triticum aestivum l. in northwest china. Field Crop Res — Wei D, Sun W, Qian W, Ye Y, Ma X The synthesis of chitosan-based silver nanoparticles and their antibacterial activity. Carbohydr Res 17 — Nat Biotechnol 21 10 — Xie W, Xu P, Liu Q Antioxidant activity of water-soluble chitosan derivatives. Bioorg Med Chem Lett 11 13 — Xing K, Shen X, Zhu X, Ju X, Miao X, Tian J, Qin S et al Synthesis and in vitro antifungal efficacy of oleoyl-chitosan nanoparticles against plant pathogenic fungi. Yacob N, Mahmud M, Talip N, Hashim K, Harun AR, Zaman K, Dahlan H Degradation of chitosan for rice crops application. Nucl Sci Tech 24 S1 —S Yang K, Xu N-S, Su WW Co-immobilized enzymes in magnetic chitosan beads for improved hydrolysis of macromolecular substrates under a time-varying magnetic field. J Biotechnol 2 — Yen MT, Mau JL Selected physical properties of chitin prepared from shiitake stipes. LWT Food Sci Technol 40 3 — Yen MT, Yang JH, Mau JL Antioxidant properties of chitosan from crab shells. Carbohydr Polym 74 4 — Yen MT, Yang JH, Mau JL Physicochemical characterization of chitin and chitosan from crab shells. Carbohydr Polym 75 1 — Yien L, Zin NM, Sarwar A, Katas H Antifungal activity of chitosan nanoparticles and correlation with their physical properties. Int J Biomater —9. Radiat Phys Chem 55 2 — Zhang Y, Zhang X, Ding R, Zhang J, Liu J Determination of the degree of deacetylation of chitosan by potentiometric titration preceded by enzymatic pretreatment. Zhao LM, Shi LE, Zhang ZL, Chen JM, Shi DD, Yang J, Tang ZX Preparation and application of chitosan nanoparticles and nanofibers. Braz J Chem Eng 28 3 — Zolghadri S, Jalilian AR, Yousefnia H, Bahrami-Samani A, Shirvani-Arani S, Mazidi M, Akhlaghi M, Ghannadi-Maragheh M Production and quality control of Ho-Chitosan for therapeutic applications. Iran J Nucl Med 18 2 :1—8. Download references. School of Biosciences, Mahatma Gandhi University, Kerala, India. You can also search for this author in PubMed Google Scholar. Correspondence to M. Reprints and permissions. Divya, K. Chitosan nanoparticles preparation and applications. Environ Chem Lett 16 , — Download citation. Received : 31 May Accepted : 11 October Published : 31 October Issue Date : March Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Shell fish processing industry is very common in coastal areas. Access this article Log in via an institution. References Abdel-Aziz HM, Hasaneen MN, Omer AM Nano chitosan-NPK fertilizer enhances the growth and productivity of wheat plants grown in sandy soil. Span J Agric Res 14 1 Article Google Scholar Abdou ES, Osheba AS, Sorour MA Effect of chitosan and chitosan-nanoparticles as active coating on microbiological characteristics of fish fingers. Int J Appl Sci Technol 2 7 — Google Scholar Agbodjato NA, Noumavo PA, Adjanohoun A, Agbessi L, Baba-Moussa L Synergistic effects of plant growth promoting rhizobacteria and chitosan on in vitro seeds germination, greenhouse growth, and nutrient uptake of maize zea mays l. Plant Physiol Biochem 40 12 — Article CAS Google Scholar Ahmed RA, Fekry A Preparation and characterization of a nanoparticles modified chitosan sensor and its application for the determination of heavy metals from different aqueous media. Int J Electrochem Sci 8 3 — CAS Google Scholar Aiping Z, Jianhong L, Wenhui Y Effective loading and controlled release of camptothecin by O-carboxymethylchitosan aggregates. Carbohydr Polym 63 1 —96 Article CAS Google Scholar Algam S, Xie G, Li B, Yu S, Su T, Larsen J Effects of paenibacillus strains and chitosan on plant growth promotion and control of ralstonia wilt in tomato.
Chitosan Nanoparticles: A Promising System in Novel Drug Delivery	Email address Sign up. Sorry, a shareable link is not currently available for this article. Jana, S. Sercombe L, Veerati T, Moheimani F, Wu S, Sood A, Hua S. The potential of intracorporeal chitosan-coated curcumin nanocrystals Chi-CUR-NC-4b were examined as a therapeutic application against endotoxemia-induced sepsis. Four in vitro and one in vivo study on the cytotoxicity of nanoparticles coated with chitosan were found. Chitosan nanoparticles having higher degree of acetylation induce resistance against pearl millet downy mildew through nitric oxide generation.
Video Upload Options	Biotechnol Adv Nanopparticles 6 — Chitosab Electrolyte Boost Google Scholar Chitpsan Chitosan for nanoparticles Chitosan nanoparticles: a survey of preparation methods. Sahariah P, Masson M. Biomed Res. Li X, Xu H, Chen Electrolyte Boost, Chen G. The fabricated nanocrystals were assessed for pharmacokinetic and pharmacodynamic parameters. The most common sources of chitin include fungi and the exoskeleton of crustaceans and insects.

Chitosan for nanoparticles -

Absorption should further be improved in chitosan poly acrylic acid nanoparticles for improved solubility for targeted drug delivery. Additionally, current limitations exist in fabrication techniques and large chain implementation due to possible difficulties in the synthesis of chitosan -based nanoparticles.

Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools. What links here Related changes Upload file Special pages Permanent link Page information Cite this page Get shortened URL Download QR code Wikidata item. Download as PDF Printable version.

Poly acrylic acid nanoparticle used for drug delivery. Fibers and Polymers. doi : ISSN S2CID PMC PMID Journal of Drug Delivery Science and Technology.

Journal of Controlled Release. Carbohydrate Polymers. July Journal of Colloid and Interface Science. Journal of Hazardous Materials. April Journal of Alloys and Compounds.

Macromolecular Bioscience. Marine Drugs. Journal of Applied Polymer Science. International Journal of Nanomedicine. Reactive and Functional Polymers. a la Victoria Km 0. c Institut für Biologie und Biotechnologie der Pflanzen, Westfälische Wilhelms Universtät — Münster, Münster, Germany.

d Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A. Normalistas , Jalisco, Guadalajara, Mexico. Polysaccharide-based nanoparticles represent a very promising drug delivery platform, particularly for the transmucosal delivery of bioactive macromolecules. Thus, the aim of this paper is to revisit the nanoprecipitation processes for preparing chitosan nanoparticles and to evaluate the influence of the process parameters on their characteristics.

Chitosan was dissolved in water as N - methylsulfonic acid chitosan or directly in aqueous acetic acid. Methanol was used as the nonsolvent diffusing phase. Nanoparticles became smaller as the polymer concentration decreased or the nonsolvent to solvent volume ratio increased.

Particles prepared in acidic media are slightly larger than those precipitated from N - methylsulfonic acid chitosan. Replacement of methanol by water in the suspension medium resulted in a notorious increase in their size. On the other hand, very little additions of Tween to the nonsolvent phase render smaller nanoparticles, with a similar mean-size values.

Nanoparticles precipitated in methanol have roughly the same dimensions, regardless of the ionic strength of the chitosan solution. These chitosan nanoparticles have good association and loading efficiency values of a model substance showing their ability as a nanocarrier for drug delivery systems.

Luque-Alcaraz, J. Lizardi-Mendoza, F. Goycoolea, I. Higuera-Ciapara and W. Argüelles-Monal, RSC Adv. Mitrut P, Docea AO, Kamal AM, Mitrut R, Calina D, Gofita E, Padureanu V, Gruia C, Streba L. Colorectal Cancer and Inflammatory Bowel Disease. Rijeka: Intech. Europe; Amir S, Shah STA, Mamoulakis C, Docea AO, Kalantzi OI, Zachariou A, Calina D, Carvalho F, Sofikitis N, Makrigiannakis A, et al.

Endocrine disruptors acting on estrogen and androgen pathways cause reproductive disorders through multiple mechanisms: a review. Salehi B, Calina D, Docea AO, Koirala N, Aryal S, Lombardo D, Pasqua L, Taheri Y, Castillo CMS, Martorell M, et al.

Docea AO, Calina D, Buga AM, Zlatian O, Paoliello MMB, Mogosanu GD, Streba CT, Popescu EL, Stoica AE, Birca AC, et al. Int J Mol Sci. Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, et al.

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci USA. Pinzaru I, Coricovac D, Dehelean C, Moaca EA, Mioc M, Baderca F, Sizemore I, Brittle S, Marti D, Calina CD, et al.

Stable PEG-coated silver nanoparticles - a comprehensive toxicological profile. Food Chem Toxicol. Buga AM, Docea AO, Albu C, Malin RD, Branisteanu DE, Ianosi G, Ianosi SL, Iordache A, Calina D. Molecular and cellular stratagem of brain metastases associated with melanoma.

Oncol Lett. CAS PubMed PubMed Central Google Scholar. Mukhopadhyay S, Goswami D, Adiseshaiah PP, Burgan W, Yi M, Guerin TM, Kozlov SV, Nissley DV, McCormick F. Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers.

Cancer Res. Article CAS PubMed PubMed Central Google Scholar. Mukhopadhyay S, Vander Heiden MG, McCormick F. The metabolic landscape of RAS-driven cancers from biology to therapy.

Nature Cancer. Article PubMed PubMed Central Google Scholar. Corbet C, Ragelle H, Pourcelle V, Vanvarenberg K, Marchand-Brynaert J, Préat V, Feron O.

Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method.

J Control Release. Kas H. Chitosan: properties, preparations and application to microparticulate systems. J Microencapsul. Felt O, Buri P, Gurny R.

Chitosan: a unique polysaccharide for drug delivery. Drug Dev Ind Pharm. Shakeel A, Saiqa I. Chitosan: Derivatives, Composites and Applications. Singla A, Chawla M. Chitosan: some pharmaceutical and biological aspects - an update. J Pharm Pharmacol. Kumar M. A review of chitin and chitosan applications.

React Funct Polym. Bravo-Osuna I, Vauthier C, Farabollini A, Palmieri G, Ponchel G. Mucoadhesion mechanism of chitosan and thiolated chitosan-poly isobutyl cyanoacrylate core-shell nanoparticles. Ali A, Ahmed S. A review on chitosan and its nanocomposites in drug delivery. Int J Biol Macromol.

Council of Europe The European Pharmacopeia. Strasburg, France, USPC, R. The United States Pharmacopeia. USP The national formulary: NF. Google Scholar. Szymańska E, Winnicka K. Stability of chitosan—a challenge for pharmaceutical and biomedical applications.

Mar Drugs. Article PubMed PubMed Central CAS Google Scholar. Viljowen J, Steenekamp J, Marais A, Kotze A. Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets.

Smart J. The basics and underlying mechanisms of mucoadhesion. Adv Drug Deliv Rev. Varum K, Ottoy M, Smidsrod O. Acid hydrolysis of chitosans. Carbohydr Polym.

Nguyen T, Hein S, Ng C-H, Stevens W. Molecular stability of chitosan in acid solutions stored at various conditions. J Appl Polym Sci. Mohammed M, Syeda J, Wasan K, Wasan E. An overview of chitosan nanoparticles and its application in non-parenteral drug delivery.

Hasanifard M, Ebrahimi-Hosseinzadeh B, Hatamian-Zarmi A, Rezayan A, Esmaeili M. Development of thiolated chitosan nanoparticles based mucoadhesive vaginal drug delivery systems. Polym Sci Ser A. Najafi S, Pazhouhnia Z, Ahmadi O, Berenjian A, Jafarizadeh-Malmiri H.

Chitosan nanoparticles and their applications in drug delivery: a review. Ghad A, Mahjoub S, Tabandeh F, Talebnia F.

Synthesis and optimization of chitosan nanoparticles: potential applications in nanomedicine and biomedical engineering. Caspian J Intern Med. Wang X, Li J, Wang Y, Cho K, Kim G, Gjyrezi A, Koenig L, Giannakakou P, Shin H, Tighiouart M, et al.

HFT-T, a targeting nanoparticle, enhances specific delivery of paclitaxel to folate receptor-positive tumors. ACS Nano. Hanahan D, Weinberg R. The hallmarks of cancer. Barnard R. Prevention of cancer through lifestyle changes. Evid-Based Compl Alt Med.

Holmes R, Vaughan T. Epidemiology and pathogenesis of esophageal cancer. Semin Radiat Oncol. Article PubMed Google Scholar. Watabe K, Nishi M, Miyake H, Hirata K. Lifestyle and gastric cancer: a case-control study. Oncol Rep. CAS PubMed Google Scholar.

Rafiei P, Haddadi A. Pharmacokinetic consequences of PLGA nano¬particles in docetaxel drug delivery. Pharm Nanotechnol. Hu K, Cao S, Hu F, Feng J. Paramagnetic nanoparticle-based targeting theranostic agent for c6 rat glioma cell.

Int J Nanomed. Liu F, Park J-Y, Zhang Y, Conwell C, Liu Y, Bathula S, Huang L. Targeted cancer therapy with novel high drug-loading nanocrystals.

J Pharm Sci. Zhao L, Feng S. Enhanced oral bioavailability of paclitaxel formu¬lated in vitamin E-TPGS emulsified nanoparticles of biodegradable polymers: in vitro and in vivo studies.

Woodrow Wilson International Center for Scholars, Washington DC, New Nanotechnology Consumer Products Inventory. Patra J, Das G, Fraceto L, Campos E, Rodriguez-Torres M, Acosta-Torres L, Diaz-Torres L, Grillo R, Swamy MK, Sharma S, et al.

Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol. Jahangirian H, Lemraski E, Webster T, Rafiee-Moghaddam R, Abdollahi Y. A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine.

Mirza A, Siddiqui F. Nanomedicine and drug delivery: a mini review. Int Nano Lett. Haba Y, Kojima C, Harada A, Ura T, Horinaka H, Kono K.

Preparation of poly ethylene glycol -modified poly amido amine dendrimers encapsulating gold nanoparticles and their heat-generating ability. Shi X, Sun K, Baker J. Spontaneous formation of functionalized dendrimer- stabilized gold nanoparticles.

J Phys Chem C. Wang N, Feng Y. Elaborating the role of natural products-induced autophagy in cancer treatment: achievements and artifacts in the state of the art.

Biomed Res Int. PubMed PubMed Central Google Scholar. Ouattara B, Simard R, Holley R, Piette G-P, Bégin A. Antibacterial activity of selected fatty acids and essential oils against six meat spoilage organisms.

Int J Food Microbiol. Sharma G, Raturi K, Dang S, Gupta S, Gabrani R. Combinatorial antimicrobial effect of curcumin with selected phytochemicals on Staphylococcus epidermidis.

J Asian Nat Prod Res. Minchin R, Martin D. Nanoparticles for molecular imaging - an overview. Islam T, Harisinghani M.

Overview of nanoparticle use in cancer imaging. Cancer Epidemiol Biomark Prev. Will O, Purkayastha S, Chan C, Athanasiou T, Darzi A, Gedroyc W, Tekkis P.

Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis. Lancet Oncol. Perrault S, Chan W.

In vivo assembly of nanoparticle components to improve targeted cancer imaging. Proceedings of the National Academy of Sciences of the United States of America Bogdanov AJ, Matuszewski L, Bremer C, Petrovsky A, Weissleder R. Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets.

Mol Imaging. Yoo D, Lee J, Shin T, Cheon J. Theranostic magnetic nanoparticles. Acc Chem Res. Hwu J, Lin Y, Josephrajan T, Hsu M, Cheng F, Yeh C, Su W, Shieh D.

Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles. J Am Chem Soc. Yu M, Jeong Y, Park J, Park S, Kim J, Min J, Kim K, Jon S. Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo.

Angew Chem. Xie J, Lee S, Chen X. Nanoparticle-based theranostic agents. Kumari A, Kumar V, Yadav S. Nanotechnology: a tool to enhance therapeutic values of natural plant products. Trends Med Res.

Chen F, Ehlerding E, Cai W. Theranostic nanoparticles. J Nucl Med. Swierczewska M, Han H, Kim K, Park J, Lee S. Polysaccharide-based nanoparticles for theranostic nanomedicine. Yang S-J, Lin F-H, Tsai H-M, Lin C-F, Chin H-C, Wong J-M, Shieh M-J.

Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms. Lapčík L, De Smedt S, Demeester J, Chabrecek P. Hyaluronan: preparation, structure, properties, and applications. Chem Rev. Kim H, Kim Y, Kim I-H, Kim K, Choi Y. ROS-responsive activatable photosensitizing agent for imaging and photodynamic therapy of activated macrophages.

Choi K, Chung H, Min K, Yoon H, Kim K, Park J, Kwon I, Jeong S. Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Kamat M, El-Boubbou K, Zhu D, Lansdell T, Lu X, Li W, Huang X.

Hyaluronic acid immobilized magnetic nanoparticles for active targeting and imaging of macrophages. Bioconjug Chem. Arpicco S, Lerda C, Dalla Pozza E, Costanzo C, Tsapis N, Stella B, Donadelli M, Dando I, Fattal E, Cattel L.

Hyaluronic acid-coated liposomes for active targeting of gemcitabine. Eur J Pharm Biopharm. Wang G, Gao S, Tian R, Miller-Kleinhenz J, Qin Z, Liu T, Li L, Zhang F, Ma Q, Zhu L.

Theranostic hyaluronic acid-iron micellar nanoparticles for magnetic-field-enhanced in vivo c ancer chemotherapy. Chem Med Chem. Ding Z, Liu P, Hu D, Sheng Z, Yi H, Gao G, Wu Y, Zhang P, Ling S, Cai L.

Biomater Sci. Sithole M, Choonara Y, Toit L, Kumar P, Pillay V. A review of semi-synthetic biopolymer complexes: modified polysaccharide nano-carriers for enhancement of oral drug bioavailability.

Pharm Dev Technol. Ahmad N. J Liq Chrom Relat Tech. Akilo O, Kumar P, Choonara Y, Toit L, Pradeep P, Modi G, Pillay V. In situ thermo-co-electroresponsive mucogel for controlled release of bioactive agent. Int J Pharm. Agotegaray M, Campelo A, Zysler R, Gumilar F, Bras C, Minetti A, Massheimer V, Lassalle V.

Influence of chitosan coating on magnetic nanoparticles in endothelial cells and acute tissue biodistribution. J Biomater Sci Polym Ed. Dhanaraj S, Muralidharan S, Venugopal V, Kanniappan P, Hui WT, Qi L.

Formulation and evaluation of chitosan nanospheres containing methotrexate targeted drug delivery system. J Young Pharm. Farhadian N, Godiny M, Moradi S, Azandaryani A, Shahlaei M.

Mater Sci Eng C Mater Biol Appl. Liu M, Chang Y, Yang J, You Y, He R, Chen T, Zhou C. Functionalized halloysite nanotube by chitosan grafting for drug delivery of curcumin to achieve enhanced anticancer efficac. J Mater Chem B. Shanmukhapuvvada Y, Vankayalapati S.

Design and development of riluzole loaded chitosan nanoparticles by emulsification crosslinking. Int J Pharm Pharm Sci. Upadhyaya L, Singh J, Agarwal V, Pandey A, Verma S, Das P, Tewari R. Process Biochem. Taghizadeh M, Ashassi-Sorkhabi H, Afkari R, Kazempour A. Cross-linked chitosan in nano and bead scales as drug carriers for betamethasone and tetracycline.

Abbas Y, Azzazy HM, Tammam S, Lamprecht A, Ali M, Schmidt A, Sollazzo S, Mathur S. Development of an inhalable, stimuli-responsive particulate system for delivery to deep lung tissue.

Colloids Surf B. Abu-Zaied M, Loutfy S, Hassan A, Elgemeie G. Novel purine thioglycoside analogs: synthesis, nanoformulation and biological evaluation in in vitro human liver and breast cancer model. Drug Des Devel Ther. Almutairi F, Abd-Rabou A, Mohamed MS. Raloxifene-encapsulated hyaluronic acid-decorated chitosan nanoparticles selectively induce apoptosis in lung cancer cells.

Bioorg Med Chem. Bae M, Al E. Nano-structured chitosan self-aggregates as a drug delivery carrier. In Proceedings of the NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech Technical Proceedings. Deepa G, Sivakumar K, Sajeevan T. Molecular simulation and in vitro evaluation of chitosan nanoparticles as drug delivery systems for the controlled release of anticancer drug cytarabine against solid tumours.

Wu S, Yang X, Lu Y, Fan Z, Li Y, Jiang Y, Hou Z. A green approach to dual-drug nanoformulations with targeting and synergistic effects for cancer therapy. Drug Deliv. Li Z, Yang F, Yang R. Synthesis and characterization of chitosan derivatives with dual-antibacterial functional groups.

Roy K, Kanwar R, Kanwar J. LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin Fe3O4-bLf nanocarriers for triple positive EpCAM, CD, CD44 colon tumor targeting and NIR MRI and CT imaging.

Arunkumar P, Indulekha S, Vijayalakshmi S, Srivastava R. In vitro comparative studies of Zein nanoparticles and composite Chitosan thermogels based injectable formulation of Doxorubicin. J Drug Deliv Sci Technol. Hwang H, Kim I, Kwon IC, Kim Y.

Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles. Barbieri S, Buttini F, Rossi A, Bettini R, Colombo P, Ponchel G, Sonvico F, Colombo G. Gomathi T, Sudha P, Florence JA, Venkatesan J, Anil S.

Fabrication of letrozole formulation using chitosan nanoparticles through ionic gelation method. Jain D, Banerjee R. Comparison of ciprofloxacin hydrochloride-loaded protein, lipid, and chitosan nanoparticles for drug delivery. J Biomed Mater Res Part B Appl Biomater. Khan A, Aqil M, Imam S, Ahad A, Sultana Y, Ali A, Khan K.

Temozolomide loaded nano lipid based chitosan hydrogel for nose to brain delivery: characterization, nasal absorption, histopathology and cell line study. Wang Z, Zhao W. Optimized preparation of gefitinib chitosan protamine nanoparticles by central composite design-response surface method.

Chinese J New Drugs. Koo H, Min K, Lee SC, Park J, Park K, Jeong S, Choi K, Kwon IC, Kim K. Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel deliver. Maya S, Kumar L, Sarmento B, Rejinold N, Menon D, Nair S, Jayakumar R.

Cetuximab conjugated O-carboxymethyl chitosan nanoparticles for targeting EGFR overexpressing cancer cells. Al-Musawi S, Jawad A, Hadi S, Hindi N.

J Glob Pharma Technol. Cavalli R, Leone F, Minelli R, Fantozzi R, Dianzani C. New chitosan nanospheres for the delivery of 5-fluorouracil: preparation, characterization and in vitro studies. Curr Drug Deliv. Sahu P, Kashaw S, Sau S, Kushwah V, Jain S, Agrawal R, Iyer A.

pH responsive 5-fluorouracil loaded biocompatible nanogels for topical chemotherapy of aggressive Melanoma.

Shukla P, Verma A, Dewangan J, Rath S, Mishra P. Chitosan coated curcumin nanocrystals augment pharmacotherapy via improved pharmacokinetics and interplay of NFκB, Keap1 and Nrf2 expression in Gram negative sepsis.

RSC Adv. Anitha A, Gopal D, Rani VV, Menon D. Preparation, characterization, in vitro drug release and biological studies of curcumin loaded dextran sulphate-chitosan nanoparticles.

Baghbani F, Chegeni M, Moztarzadeh F, Hadian-Ghazvini S, Raz M. Keerthikumarc W, Jalalpure S, Mallashwara Rao PVS. Chitosan encapsulated Curcumin nanoparticles as an effective drug delivery system for oral cancer treatment. Indian Drugs. Rajan S, Pandian A, Palaniappan T.

Curcumin loaded in bovine serum albumin-chitosan derived nanoparticles for targeted drug delivery. Bull Mater Sci. Shahiwala A, Shehab N, Khider M, Khan R. Chitosan nanoparticles as a carrier for indigofera intricata plant extract: Preparation, characterization and anticancer activity.

Curr Canc Ther Rev. Alipour M, Bigdeli M, Aligholi H, Rasoulian B, Khaksarian M. Sustained release of silibinin-loaded chitosan nanoparticle induced apoptosis in glioma cells. J Biomed Mater Res A.

George D, Maheswari P, Begum KMM. Chitosan-cellulose Hydrogel Conjugated With L-histidine and zinc oxide nanoparticles for sustained drug delivery: kinetics and in-vitro biological studies. Agotegaray M, Campelo A, Zysler R, Gumilar F, Bras C, Gandini A, Minetti A, Massheimer V, Lassalle V.

Magnetic nanoparticles for drug targeting: from design to insights into systemic toxicity. Preclinical evaluation of hematological, vascular and neurobehavioral toxicology.

Chaichanasak N, Rojanapanthu P, Yoon Y, Gritsanapan W, Chirachanchai S, Sathirakul K, Nualsanit T, Seong J, Baek S. Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression.

Calvo N, Sreekumar S, Sveraz L, Lamas M, Moerschbacher B, Leonardi D. Design and characterization of chitosan nanoformulations for the delivery of antifungal agents.

Article CAS PubMed Central Google Scholar. Elsalam EA, Shabaiek H, Abdelaziz M, Khalil I, El-Sherbiny I. Fortified Hyperbranched PEGylated Chitosan-Based Nano-In-Micro Composites for Treatment of Multiple Bacterial Infections. Singh K, Mishra A, Singh A.

Synthesis characterization and in vitro release study of ciprofloxacin-loaded chitosan nanoparticle. Manimekalai P, Dhanalakshmi R, Manavalan R. Preparation and characterization of ceftriaxone sodium encapsulated chitosan nanoparticles.

Int J App Pharm. Jamil B, Habib H, Abbasi S, Nasir H, Rahman A, Rehman A, Bokhari H, Imran M. Cefazolin loaded chitosan nanoparticles to cure multi drug resistant Gram-negative pathogens. Article PubMed CAS Google Scholar.

Manuja A, Dilbahgi N, Kaur H, Saini R, Banrela M, Chopra M, Manuja B, Kumar R, Kumar S, Riyesh T, et al. Chitosan quinapyramine sulfate nanoparticles exhibit increased trypanocidal activity in mice.

Nano-Struct Nano-Objects. Niaz T, Shabbir, S Manzoor S, Rehman A, Rahman A, Nasir H, Imran M. Antihypertensive nano-ceuticales based on chitosan biopolymer: physico-chemical evaluation and release kinetics.

No Title. Dhayabaran V, Margret A, Begum T. Polymeric nano composites as dexterous drug carriers in steering up brain drug targeting: an approach to combat depression. Asian J Microbiol Biotechnol Environ Sci. Yu F, Zheng M, Zhang A, Han Z. A cerium oxide loaded glycol chitosan nano-system for the treatment of dry eye disease.

Fathi M, Majidi S, Zangabad P, Barar J, Erfan-Niya H, Omidi Y. Chitosan-based multifunctional nanomedicines and theranostics for targeted therapy of cancer.

Med Res Rev. Babu A, Templeton A, Munshi A, Ramesh R. Nanodrug delivery systems: a promising technology for detection, diagnosis, and treatment of cancer. Pharm Sci Tech. Garg U, Chauhan S, Nagaich U, Jain N. Current advances in chitosan nanoparticles based drug delivery and targeting.

Adv Pharm Bull. Pacheco C, Sousa A, Sarmento B. Chitosan-based nanomedicine for brain delivery: where are we heading? Sercombe L, Veerati T, Moheimani F, Wu S, Sood A, Hua S.

Advances and challenges of liposome assisted drug delivery. Front Pharmacol. Rizvi S, Saleh A. Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J. Singh A, Biswas A, Shukla A, Maiti P. Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles.

Signal Transduct Target Ther. Ahmad Z, Shah A, Siddiq M, Kraatz H-B. Polymeric micelles as drug delivery vehicles. Vu-Quang H, Vinding M, Nielsen T, Ullisch M, Nielsen N, Kjems J. Theranostic tumor targeted nanoparticles combining drug delivery with dual near infrared and 19F magnetic resonance imaging modalities.

Jiang G-B, Quan D, Liao K, Wang H.

HCitosan of Chigosan, Department of Nnaoparticles Sciences, Guru Caloric intake for muscle building University of Science and Electrolyte Boost. Cjitosan Chitosan for nanoparticles of nanoparticles to manipulate the molecules and nanopatticles structures has revolutionized Electrolyte Boost conventional drug delivery system. The chitosan nannoparticles, because of their biodegradability, biocompatibility, nanopsrticles stability, low toxicity, simple annoparticles mild Chitosan for nanoparticles methods, offer a valuable tool nano;articles novel drug delivery systems Electrolyte Boost the Chronic hyperglycemia and inflammation scenario. Besides ionotropic gelation method, other methods such as microemulsion method, emulsification solvent diffusion method, polyelectrolyte complex method, emulsification cross-linking method, complex coacervation method and solvent evaporation method are also in use. The chitosan nanoparticles have also been reported to have key applications in parentral drug delivery, per-oral administration of drugs, in non-viral gene delivery, in vaccine delivery, in ocular drug delivery, in electrodeposition, in brain targeting drug delivery, in stability improvement, in mucosal drug delivery in controlled drug delivery of drugs, in tissue engineering and in the effective delivery of insulin. The present review describes origin and properties of chitosan and its nanoparticles along with the different methods of its preparation and the various areas of novel drug delivery where it has got its application. Nanoparticles NPs assumed Electrolyte Boost important role in Electrolyte Boost area of Chitosan for nanoparticles delivery. Despite the nanoparticlez of Body fat calipers tips including Nqnoparticles are growing Chitosan for nanoparticles the Chtosan Chitosan for nanoparticles, their nanopartiles effects on Chitosan for nanoparticles Cbitosan system are often ignored or Chitosan for nanoparticles. One of the most studied polymers in the nano based drug delivery system field is chitosan Chit. In the scientific literature, although the physicochemical properties [molecular weight MW or deacetylation degree DDA ] of the chitosan, endotoxin contamination and appropriate testing controls are rarely reported, they can strongly influence immunotoxicity results. The present work aimed to study the immunotoxicity of NPs produced with different DDA and MW Chit polymers and to benchmark it against the polymer itself.

Video

Preparation \u0026 Characterization: SDF-1α-Chitosan-Dextran Sulfate Nanoparticles l Protocol Preview