Bitter orange supplements are marketed to promote weight loss by reducing appetite and are available over the counter. How it works: Bitter orange is believed to encourage weight loss by increasing your basal metabolic rate — or calories burned at rest — therein stimulating fat breakdown and suppressing appetite 8.

Effectiveness: Though research has shown that synephrine increases the numbers of calories burned, its effect on weight loss is inconclusive 9.

A review of 23 studies found that 20—35 mg of synephrine per day increased metabolic rate and had a modest impact on weight loss. However, some of the studies resulted in no weight loss or even weight gain after treatment with synephrine Side effects: Reported side effects of synephrine include increased heart rate, elevated blood pressure and anxiety.

Summary Bitter orange contains a compound called synephrine that may boost metabolism and encourage weight loss. However, research shows mixed results. Made with an extract derived from the peel of the Garcinia gummi-gutta fruit, garcinia cambogia pills are used to suppress appetite and promote weight loss.

How it works: Garcinia cambogia extract contains hydroxycitric acid HCA , which may reduce appetite by increasing serotonin levels in your brain and reducing the metabolism of carbohydrates Effectiveness: A review of 12 studies found that participants who supplemented with garcinia cambogia containing 1,—2, mg of HCA per day for 2—12 weeks lost an average of 1.

Another study in 28 people demonstrated that garcinia cambogia was more effective at reducing appetite, increasing fullness and decreasing hunger than a placebo However, other studies have shown that garcinia cambogia has little to no effect on appetite or weight loss Side effects: Though generally considered safe, consuming garcinia cambogia may lead to side effects in some people, such as headaches, diarrhea, nausea, irritability and even liver failure in extreme cases Summary Some research shows that garcinia cambogia suppresses appetite and promotes weight loss.

Glucomannan is a type of soluble fiber derived from the edible roots of the konjac plant. How it works: Glucomannan is understood to encourage weight loss by reducing appetite, increasing feelings of fullness, slowing digestion and blocking the absorption of fat and protein A review of six studies found that 1.

However, researchers concluded that the results were not statistically significant and that larger and longer-term studies are needed Side effects: Glucomannan may cause side effects such as constipation, diarrhea, nausea and abdominal discomfort Summary Glucomannan is a type of soluble fiber that may promote short-term weight loss.

However, results from studies are inconclusive. Hoodia gordonii is a type of succulent plant traditionally used by indigenous people in southern Africa as an appetite suppressant.

Extracts from Hoodia gordonii are used in dietary supplements that claim to reduce appetite and boost weight loss. How it works: Though the mechanism by which Hoodia gordonii suppresses hunger is unknown, some scientists link it to a compound called P57, or glycoside, which may impact your central nervous system and decrease appetite Effectiveness: There is little evidence to support the use of Hoodia gordonii to promote weight loss, and few human studies have examined the plant.

A day study in 49 overweight women found that 2. Side effects: Hoodia gordonii may lead to headaches, nausea, increased heart rate, high blood pressure and impaired liver function Summary Currently, no evidence supports the use of Hoodia gordonii for weight loss or reduced appetite.

Green coffee bean extract is a substance derived from the raw seeds of the coffee plant and is popularly used as a weight loss supplement. How it works: Green coffee beans contain high levels of chlorogenic acid, which may inhibit fat accumulation.

The extract also contains caffeine , which decreases appetite Effectiveness: A recent study in people with metabolic syndrome showed that those taking mg of green coffee bean extract per day experienced a significant decrease in waist circumference and appetite compared to a placebo group An analysis of three studies found that overweight participants who took either or mg per day of green coffee extract for up to 12 weeks experienced an average weight loss of 6 pounds 2.

Side effects: Though green coffee bean extract is generally well tolerated, it may cause headaches and increased heart rate in some people.

Summary Several research studies have demonstrated that green coffee bean extract may reduce appetite and promote weight loss. The guarana plant has been used for hundreds of years for various purposes, including appetite suppression How it works: Guarana contains more caffeine than any other plant in the world.

Caffeine stimulates your nervous system and has been shown to decrease appetite and boost metabolism Effectiveness: Insufficient evidence exists to support the use of guarana to suppress appetite and promote weight loss.

However, test-tube and animal studies show that guarana extract may boost metabolism and limit fat cell production by suppressing certain genes Side effects: Because guarana is high in caffeine, it may cause insomnia, headaches, nervousness and increased heart rate and anxiety, especially when taken in high doses Summary Guarana — which is especially high in caffeine — may boost metabolism, but more research is needed to determine whether it suppresses appetite or promotes weight loss.

Acacia fiber, also known as gum arabic, is a type of indigestible fiber promoted as a means of suppressing appetite and promoting fullness. Yerba mate is a plant native to South America.

Some research has suggested that taking capsules containing a total of 3 g of yerba mate daily for 12 weeks may help reduce body fat and improve the waist-hip ratio of people with obesity. Moreover, a study of 12 healthy women has indicated that taking 2 g of yerba mate before performing a minute cycling exercise reduced appetite and also boosted metabolism, focus, and energy levels.

Yerba mate appears to be safe and does not seem to produce any severe side effects. However, drinking yerba mate very hot and reusing the same leaves may lead to a higher risk of esophageal and other types of cancer. Yerba mate is a plant known for its energy-boosting properties, and it may also help with appetite reduction and weight loss.

Studies suggest that the caffeine in coffee may help promote weight loss by:. It seems that ingesting caffeine 0. Nevertheless, note that a high caffeine intake may raise blood pressure in some people.

The caffeine in coffee may help reduce appetite, delay stomach emptying, and influence appetite hormones, all of which can help you eat less. Caffeine may also increase fat burn and aid weight loss. The items listed above may offer a natural approach to weight loss alongside dietary measures and exercise.

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

VIEW ALL HISTORY. Making a few small changes to your morning routine can help you lose weight and keep it off.

This article tells you how. Nutrient-rich superfoods can benefit your health in many ways, including by helping you lose weight. Here are 20 of the best superfoods for weight…. Men looking to lose weight have a number of dietary patterns to choose from.

Here are the 10 best weight loss diet plans for men. Green tea extract is a concentrated supplemental form of green tea. Here are 10 science-based benefits of green tea extract. This is a detailed article about CLA Conjugated Linoleic Acid , a natural fatty acid that has become very popular as a weight loss supplement.

Coffee contains caffeine, a stimulant substance that is proven to increase the release of fats from the fat tissues and boost the resting metabolic…. Yerba mate is a type of tea with powerful benefits for your health and weight.

Here are 7 ways that drinking yerba mate can improve your health. Patients with diabetes who used GLP-1 drugs, including tirzepatide, semaglutide, dulaglutide, and exenatide had a decreased chance of being diagnosed…. A Quiz for Teens Are You a Workaholic?

How Well Do You Sleep? Health Conditions Discover Plan Connect. Nutrition Evidence Based 10 Natural Appetite Suppressants That May Help You Lose Weight. Medically reviewed by Amy Richter, RD , Nutrition — By Arlene Semeco, MS, RD — Updated on August 30, Fenugreek Glucomannan Gymnema sylvestre Griffonia simplicifolia Caralluma fimbriata Green tea Conjugated linoleic acid Garcinia cambogia Yerba mate Coffee Bottom line Certain herbs and plants may help promote weight loss by reducing appetite.

Glucomannan and other viscous fiber. Gymnema sylvestre. Griffonia simplicifolia 5-HTP. Reported side effects include nausea, GI discomfort, and headache. Be aware that ConsumerLab.

com has found that many Garcinia products do not contain claimed amounts of HCA. Among the 13 Garcinia supplements selected for testing by ConsumerLab. com, only six contained their labeled amounts of HCA. Labels may refer to the fruit of Garcinia cambogia or to the active compound HCA.

Due to its ability to reduce the perception of sweet taste, there has been speculation that gymnema may reduce sugar cravings and help control appetite. Interestingly, both groups did show a significant decrease in consumption of cake foods and an increase in consumption of fruit compared to baseline, which suggests that participants in both groups may have altered their intake of sugar-containing foods because they knew they were in a sugar-reduction study Turner, Nutrients Caralluma fimbriata is a type of edible cactus.

Although traditionally used for its appetite-suppressing effects, evidence to support this is effect is mixed, and it does not seem to help with weight loss. One small clinical study showed that 1, mg of Caralluma fimbriata extract given daily for 60 days reduced appetite and waist circumference compared to placebo, but it did not significantly reduce weight or body fat Kuriyan, Appetite However, a slightly larger study using the same dose at mg twice daily for 12 weeks did not significantly reduce appetite, body weight, body mass index, hip circumference, or waist circumference compared to placebo Arora, Perspect Clin Res No serious adverse events have been reported with Caralluma fimbriata in clinical studies, although nausea, constipation, stomach pain, and other GI issues have been reported.

The long-term safety of this ingredient is unknown, as all studies have been short-term. Several small studies suggested that ginger may slightly help people who are overweight or obese, although results are mixed and it is unclear how ginger might promote weight loss. Ketone supplements such as Spark Keto and deltaG have been touted as helping to burn fat and manage cravings but have not been proven to promote fat loss or weight loss.

These supplements generally contain beta-hydroxybutyrate, which is one of the "ketones" or "ketone bodies" naturally produced by the liver as an alternate source of energy in response to low dietary intake of carbohydrates such as during fasting or when following a very low carbohydrate diet.

Because ketones are derived from fat, production of ketones may help promote fat loss and weight loss Gershuni, Curr Nutr Rep ; McPherson, J Physiol Biochem — but this does not mean that taking ketones helps with weight loss.

Another study, among 18 adults with prediabetes showed that consuming mL about 3. oz of a beta-hydroxybutyrate drink deltaG®, TdeltaS Global providing mg of a beta-hydroxybutyrate derivative per kilogram of lean body weight did not significantly reduce hunger, affect levels of hormones that regulate appetite ghrelin and peptide YY , or influence eating behavior for 2.

Be aware that some laboratory research suggests that increasing blood levels of beta-hydroxybutyrate reduces the production of ketones by the body Taggart, J Biol Chem , indicating that supplementation with beta-hydroxybutyrate may reduce the amount of body fat that is used for energy — an effect that could actually impair fat loss.

Spinach has been promoted for weight loss due to its thylakoids constituents, which have been shown in laboratory studies to increase the release of appetite-suppressing hormones. However, supplementation with a product containing spinach-derived thylakoids Appethyl does not seem to significantly improve weight loss or affect appetite.

Peanuts , especially the skin of peanuts, contain antioxidant and anti-inflammatory constituents. Since inflammation and oxidative stress have been linked with obesity-related comorbidities such as cardiovascular disease , researchers have speculated that regular consumption of peanuts may be beneficial.

However, a clinical study found no weight loss benefit with peanuts, although there was a decrease in total cholesterol. Those in the skinned peanut group also showed a slightly greater reduction in BMI about 0.

Interestingly, women eating peanuts showed a slight but statistically significant increase in tumor necrosis factor TNF -alpha, a marker of inflammation, while those in the control group showed a slight decrease Fialho, J Sci Food Agric As noted above, there's no solid evidence that any dietary supplement has significant natural appetite-suppressing effects, but some may have modest short-term benefits.

Be aware that there may be risks associated with the use of these supplements, and no supplement has been shown to be more effective at weight-control than changes in the diet. Also keep in mind that ConsumerLab. com has found that many supplements do not actually contain the amounts of ingredients claimed on their labels, and the chance of this is particularly high when an ingredient receives media attention as an appetite suppressant or weight loss aid, and companies rush to sell it.

In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources.

These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced.

All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article:.

Sign In Here. For your privacy, only your first name from your account followed by a random number will appear with your comment.

Your last name and email address will not be displayed. Did taking a ketone supplement help with weight management a recent study? Find out in our article about supplements for weight management. Did supplementing with gymnema which may alter taste perception curb sugar cravings and reduce food intake in a recent study?

Find out in our updated CL Answer about supplements for reducing appetite and weight. Also see our CL Answer about supplements for blood sugar control to learn about use of gymnema in people with diabetes.

A CL Member asked if Spark Keto a. K3 Spark , can help with weight management. Find out what research suggests in the Appetite Suppressants section of our CL Answer about Supplements for Weight. zuPOO is marketed for gut support and as a colon cleanser for weight management.

Find out if research supports these claims and if ingredients in zuPOO are safe. Find out if taking Provitalize, a probiotic supplement that also contains turmeric extract, moringa leaf extract, curry leaf extract and piperine BioPerine , is safe and beneficial for weight management.

Find out if supplements such as vitamin E, fish oil, milk thistle, curcumin, choline, probiotics, vitamin D, reishi mushroom, or extra virgin olive oil are beneficial for fatty liver disease and learn which diet Mediterranean, ketogenic, DASH, or fasting diets seems to have greatest benefit.

Learn about the pros and cons of sugar substitutes and artificial sweeteners summarized in our table within this article. Learn more about psyllium found in Metamucil , including effects on appetite and hunger control, results from clinical studies and safety.

Learn more about forskolin including weight loss, diet, preventing asthma attacks and its proposed effects on the body.

Learn more about weight loss supplements, including our lab test results and product comparisons. Can yacon syrup can help with weight loss? Learn more, including clinical evidence, side effects, and dosage. Does white kidney bean extract help promote weight loss? Find out more including evidence from clinical studies and dosage.

Learn more about Skinny Fiber, including its key ingredient glucomannan, evidence from clinical studies, dosage info, and safety. The "Updated" date indicates when new information was most recently added to this article.

In the full article, the newest information is highlighted in yellow.

Capsiplex Trim - A precision fat burner for females seeking to reveal toned curves and maximize a slim, athletic figure through diligent training. Both weight loss supplements deliver robust appetite suppression to reduce caloric intake during cutting phases.

They also provide an energy boost to optimize intense workouts when calorie-restricted. For those willing to put in the hard training, Capsiplex can accelerate the path to achieving peak physical condition.

The synergy between these ingredients enables Capsiplex to excel as a pre-workout thermogenic fat burner and appetite suppressant. Capsimax and caffeine are particularly key for boosting calorie burn during intensive training. Capsiplex is an ideal appetite suppressant and fat burner supplement for active individuals with regular, high-intensity workouts.

It excels for bodybuilders or athletes who are cutting calories to reveal lean muscle, thanks to thermogenic and energy-boosting effects. The formula provides added benefits for intensive training cycles where increased calorie burn and energy is desired.

Capsiplex helps maintain performance despite being calorie-restricted. However, some may need to moderate dosage due to the caffeine content if highly stimulant-sensitive. Those who experience any undesirable effects can take advantage of the day refund policy to get their money back.

CLICK to view Zotrim latest price and and current special offers. Zotrim is the premier herbal appetite suppressant supplement on the market today. It has outperformed prescription medications in clinical trials for hunger control and weight loss results.

This level of evidence sets it apart from other natural appetite suppressants. Similar to prescription diet pills like Phentermine and compounded Semaglutide , Zotrim's primary benefit is powerful appetite suppression. It also provides a modest energy increase.

However, it is not as multifunctional as some other top-ranked weight loss supplements. The formula works best combined with a healthy diet. Users report substantially decreased food cravings and hunger, leading to credible weight loss over time.

In summary, Zotrim stands above other natural appetite suppressants due to unparalleled clinical evidence confirming its effectiveness for hunger control and weight reduction.

While more limited in scope than some supplements, its potent appetite suppressing effects make it an excellent option for dieters seeking assistance with cravings. Extensive research demonstrates these natural ingredients reduce hunger and promote weight loss without adverse effects. Each herb has individual benefits, but their appetite suppressing potentials synergize when combined.

Clinical trials on obese subjects show the trio together elicits more significant weight loss than any one alone. The herbs appear to increase satiety by slowing gastric emptying, allowing food to remain in the stomach longer. This helps control hunger and caloric intake.

Zotrim also includes B vitamins and caffeine to combat fatigue that may occur alongside the reduced calorie intake. Zotrim is best suited for individuals whose primary goal is suppressing appetite and controlling hunger cravings. It is also a great fit for those who favor simple herbal formulations over pharmaceuticals or multi-ingredient supplements.

While other top diet pills may provide greater thermogenic fat burning, Zotrim's natural ingredients offer hunger suppression on par with prescription medications.

In clinical evaluations, Zotrim has outperformed weight loss drugs for curbing appetite and reducing calories. Its focus on hunger control provides simplicity while still delivering meaningful weight loss results over time.

For dieters seeking robust appetite control from gentle herbal extracts, Zotrim is an excellent option backed by clinical testing. While the formula is more limited in scope, it excels at targeting and taming hunger.

Appetite suppressants can provide valuable assistance for weight management, coming in two main forms: natural OTC supplements and prescription medications. Understanding the key differences helps determine which option may be better suited for an individual's needs and circumstances.

Natural appetite suppressants typically contain plant extracts, fibers, vitamins, minerals or amino acids.

For example, the fiber glucomannan from konjac root offers potent hunger control without side effects. Natural ingredients influence metabolism, blood sugar, and other factors to support easier weight loss. OTC appetite suppressants are widely accessible without a prescription and far more affordable than prescription options.

Prescription medications are FDA-approved drugs , generally prescribed only for obese patients or those with BMIs over 30 failing to lose weight through diet and exercise alone.

They offer proven effectiveness under medical supervision, but also potential side effects like nausea, dizziness, and headaches. Some also carry risks of severe reactions.

Prescription suppressants may not be suitable for those with certain health conditions or taking other medications.

Access requires both a prescription and insurance coverage or out-of-pocket costs. Natural OTC suppressants provide easier access and fewer side effects, but effectiveness varies widely by brand. Prescription medications have clinical evidence but greater risks and costs.

The right choice depends on an individual's health status, risks versus benefits, and affordability. Consulting a doctor can help weigh all factors to determine the best appetite suppression method. What is the science that powers natural appetite suppressant supplements?

How do they help us feel less hungry and achieve our weight loss goals? Appetite suppressant pills and supplements operate based on the principle of satiety, which is the satisfied feeling of fullness after eating. They either take up physical space in your stomach, creating a sensation of fullness, or they target the brain's adrenal gland, inhibiting it from sending hunger signals to your body.

The hypothalamus is a critical player in this process. It's the region of the brain responsible for regulating appetite.

Natural OTC appetite suppressants, derived from nutrients, herbs, and specific plants, can promote weight loss by decreasing appetite, slowing the rate at which the stomach empties, blocking the absorption of certain nutrients, and influencing hormones related to appetite.

Prescription appetite suppressants have also proven effective in aiding weight loss. They typically function by blocking the reuptake of the chemicals serotonin and norepinephrine, which generate the satiety feeling experienced after consuming a large meal.

This regulatory mechanism underscores the importance of maintaining balanced brain chemistry for healthy appetite control.

Recently, scientists have made exciting discoveries in the field of appetite suppression. For instance, researchers identified an 'anti-hunger' molecule produced during intense exercise. This molecule travels to the brain and diminishes appetite, indicating the crucial role of physical activity in weight management and appetite control.

However, it's essential to remember that while natural appetite suppressants can assist in weight loss, they should not replace a balanced diet and regular exercise. They are tools to complement lifestyle changes, not magic pills to solve weight issues overnight.

Here are some key things to look for when choosing an over-the-counter OTC appetite suppressant supplement:. Checking for these aspects will help you choose a quality OTC appetite suppressant for effective, safe weight loss.

Consult a doctor before use if you have any medical conditions. Together, these powerful natural ingredients offer safe and effective hunger control and fat burning for weight management.

They provide clinically-backed solutions to curb cravings and overeating. The results you experience with appetite suppressants depend on several factors - the specific suppressant used, genetics, lifestyle, diet, and exercise efforts. For best results, combine suppressants with positive lifestyle habits like regular exercise, healthy nutrition, and adequate sleep.

It's also vital to take suppressants as directed and stay well hydrated by drinking plenty of fluids daily. Proper hydration reduces side effects and supports health alongside decreased calorie intake.

Active lifestyles require even more hydration. Remember, there is no universal weight loss solution. Success requires an individualized approach based on your unique needs and circumstances.

View appetite suppressants as helpful tools rather than cure-alls, and adopt sustainable diet and exercise strategies. With patience and dedication to an overall healthy lifestyle, you'll begin to see meaningful results over time.

Appetite suppressants complement other efforts, but are not magic pills on their own. A multifaceted approach is ideal for long-term weight management. Latest news: Best supplement for menopause weight gain. In this article, we will take a closer look at the. This website uses cookies, including third-party cookies, to ensure the correct functioning and performance of the site, to optimise your user experience and to analyse the traffic on our site.

For more information read our policy page here. Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings. If you disable this cookie, we will not be able to save your preferences. This means that every time you visit this website you will need to enable or disable cookies again.

Skip to content. Facebook Instagram X Logo. Search Close this search box. Join Us. Healthy Living. Elmarie Jensen February 9, am. Sounds familiar? Stop food cravings with supplements. Best supplements to stop or reduce carb and other food cravings:.

Magnesium is responsible for regulating not only glucose and insulin levels, but also the neurotransmitter dopamine. A magnesium deficiency can result in intense sugar cravings, especially for chocolate. B Vitamins play a vital role in the optimal metabolism of carbohydrates.

This, in turn, contributes to sustained energy levels and healthy brain function, instead of carbs getting stored as fat. Furthermore, B vitamins play an important role in reducing stress, which as we know, can often trigger our need to overeat. Overall, B vitamins are regarded as essential supplements to curb sugar cravings.

Zinc is an essential mineral that plays a vital role in your metabolism and energy, as well as the digestion of your food. It regulates the production of insulin. A zinc deficiency may result in sugar cravings and an increased appetite.

This, in turn, helps with appetite control as it reduces our carb cravings. Resveratrol is a chemical found in red wine. Resveratrol decreases the production of cortisol, a hormone that is associated with stress.

Decreased cortisol levels leads to a decrease in food cravings and appetite. L-glutamine is an amino acid that plays an important role in balancing blood sugar levels and shutting down the cravings signal from the brain. It also helps to maintain and balance serotonin levels , which in turn helps to control your mood levels and carb cravings.

Gamma-aminobutyric acid GABA is a neurotransmitter chemical messenger that assists your body to have the energy it needs to function. This, in turn, reduces overeating.

Lipase is a digestive enzyme that helps your body digest fats. A lipase deficiency may contribute to sugar cravings. It helps to reduce cravings, hunger and the desire to binge eat. Alpha-lipoic acid is an organic compound with powerful antioxidant abilities.

It helps to stabilise blood sugar levels, speed up carbohydrate metabolisation and reduce the desire to overeat. Sources bengreenfieldfitness. Was this article useful? Allow us to walk beside you with our affordable hospital plans.

Life Extension Optimized Saffron Extract with Satiereal, 90 Veg Caps - Life Extension Optimized Saffron, saffron extract, saffron supplement that helps you fight the urge to snack, non-GMO, gluten-free, vegetarian, 60 vegetarian capsules.

Caralluma Fimbriata Extract mg - Maximum Strength Natural Endurance Support, Best Vegan Caps for Women and Men - Capsules. NatureGenX LeptinXT - Leptin Supplements for Weight Loss for Women - Extra Strength, Fat Burner - 60 Ct. Premium Saffron Extract Vegan 60 Caps. BioSource Labs Complex ProMAX Premium Diet Drops 1 x 2 oz Bottle.

Right Health Nutra - Saffron Extract MuscleMeds Feast Mode Appetite Stimulant Weight Gain Pills Digestive Enzymes Safe and Effective 90 Caps, Unflavored, 90 Count.

Weight Loss. Ready to Drink Shakes. Your recently viewed items and featured recommendations. Back to top. Get to Know Us. Make Money with Us. Amazon Payment Products. Let Us Help You. Conditions of Use Privacy Notice Your Ads Privacy Choices © , Amazon.

com, Inc. or its affiliates. However, cases of liver toxicity have been reported with green tea extracts. Green tea may also interact with certain medications including MAO inhibitors, proteasome inhibitors, certain beta-blockers, statins, and thyroid medication such as levothyroxine Synthroid.

For more details about the side effects and possible drug interactions of green tea, see the Concerns and Cautions section of our green tea review. Yacon syrup is made from the tuberous roots of the yacon plant that is high in a prebiotic soluble fiber called fructooligosaccharides, or FOS Lachman, Plant Soil Environ Although it is promoted for appetite suppression and weight loss, results from clinical research are mixed.

One study in obese, premenopausal women following a low-calorie diet and modest exercise regimen showed that 10 grams of FOS from yacon syrup about 2 to 3 teaspoonfuls of syrup given daily for 4 months reduced body weight by about 33 lbs.

and also decreased waist circumference and body mass index compared to baseline, while women given a placebo had a slight increase in weight Genta, Clin Nutr On the other hand, a study in Brazil among 40 normal weight and obese women found that 40 grams of yacon syrup containing 14 grams of FOS consumed with a breakfast high in fat and carbohydrates did not decrease levels of ghrelin or GLP-1 hormones that help regulate appetite after eating nor decrease hunger or desire to eat up to three hours after the meal, compared to placebo Adriano, Food Res Int Like other ingredients with high fiber content, taking large amounts of yacon syrup or root powder can cause gastrointestinal discomfort, gas and bloating.

In the clinical weight loss study mentioned above, a daily dose of about 10 grams did not cause side-effects, but when the dose was doubled, women experienced significant diarrhea, gas and nausea.

If you decide to try yacon, be sure to choose a syrup or supplement that lists the FOS content on the label. HCA may be more effective in women than men and in people who are not markedly obese.

A typical dose provides mg of HCA taken three to four times a day. However, as discussed in the What to Consider When Using section of our Garcinia cambogia review, when and how you take the supplement may be important in determining its efficacy. HCA seems to be generally safe, but no long-term studies have been conducted.

Reported side effects include nausea, GI discomfort, and headache. Be aware that ConsumerLab. com has found that many Garcinia products do not contain claimed amounts of HCA.

Among the 13 Garcinia supplements selected for testing by ConsumerLab. com, only six contained their labeled amounts of HCA. Labels may refer to the fruit of Garcinia cambogia or to the active compound HCA.

Due to its ability to reduce the perception of sweet taste, there has been speculation that gymnema may reduce sugar cravings and help control appetite. Interestingly, both groups did show a significant decrease in consumption of cake foods and an increase in consumption of fruit compared to baseline, which suggests that participants in both groups may have altered their intake of sugar-containing foods because they knew they were in a sugar-reduction study Turner, Nutrients Caralluma fimbriata is a type of edible cactus.

Although traditionally used for its appetite-suppressing effects, evidence to support this is effect is mixed, and it does not seem to help with weight loss. One small clinical study showed that 1, mg of Caralluma fimbriata extract given daily for 60 days reduced appetite and waist circumference compared to placebo, but it did not significantly reduce weight or body fat Kuriyan, Appetite However, a slightly larger study using the same dose at mg twice daily for 12 weeks did not significantly reduce appetite, body weight, body mass index, hip circumference, or waist circumference compared to placebo Arora, Perspect Clin Res No serious adverse events have been reported with Caralluma fimbriata in clinical studies, although nausea, constipation, stomach pain, and other GI issues have been reported.

The long-term safety of this ingredient is unknown, as all studies have been short-term. Several small studies suggested that ginger may slightly help people who are overweight or obese, although results are mixed and it is unclear how ginger might promote weight loss. Ketone supplements such as Spark Keto and deltaG have been touted as helping to burn fat and manage cravings but have not been proven to promote fat loss or weight loss.

These supplements generally contain beta-hydroxybutyrate, which is one of the "ketones" or "ketone bodies" naturally produced by the liver as an alternate source of energy in response to low dietary intake of carbohydrates such as during fasting or when following a very low carbohydrate diet.

Because ketones are derived from fat, production of ketones may help promote fat loss and weight loss Gershuni, Curr Nutr Rep ; McPherson, J Physiol Biochem — but this does not mean that taking ketones helps with weight loss. Another study, among 18 adults with prediabetes showed that consuming mL about 3.

oz of a beta-hydroxybutyrate drink deltaG®, TdeltaS Global providing mg of a beta-hydroxybutyrate derivative per kilogram of lean body weight did not significantly reduce hunger, affect levels of hormones that regulate appetite ghrelin and peptide YY , or influence eating behavior for 2.

Be aware that some laboratory research suggests that increasing blood levels of beta-hydroxybutyrate reduces the production of ketones by the body Taggart, J Biol Chem , indicating that supplementation with beta-hydroxybutyrate may reduce the amount of body fat that is used for energy — an effect that could actually impair fat loss.

Spinach has been promoted for weight loss due to its thylakoids constituents, which have been shown in laboratory studies to increase the release of appetite-suppressing hormones. However, supplementation with a product containing spinach-derived thylakoids Appethyl does not seem to significantly improve weight loss or affect appetite.

Peanuts , especially the skin of peanuts, contain antioxidant and anti-inflammatory constituents. Since inflammation and oxidative stress have been linked with obesity-related comorbidities such as cardiovascular disease , researchers have speculated that regular consumption of peanuts may be beneficial.

However, a clinical study found no weight loss benefit with peanuts, although there was a decrease in total cholesterol. Those in the skinned peanut group also showed a slightly greater reduction in BMI about 0. Interestingly, women eating peanuts showed a slight but statistically significant increase in tumor necrosis factor TNF -alpha, a marker of inflammation, while those in the control group showed a slight decrease Fialho, J Sci Food Agric As noted above, there's no solid evidence that any dietary supplement has significant natural appetite-suppressing effects, but some may have modest short-term benefits.

Be aware that there may be risks associated with the use of these supplements, and no supplement has been shown to be more effective at weight-control than changes in the diet. Also keep in mind that ConsumerLab.

com has found that many supplements do not actually contain the amounts of ingredients claimed on their labels, and the chance of this is particularly high when an ingredient receives media attention as an appetite suppressant or weight loss aid, and companies rush to sell it.

In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources.

These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced.

All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable.

The following sources are referenced in this article:. Sign In Here. For your privacy, only your first name from your account followed by a random number will appear with your comment. Your last name and email address will not be displayed.

Did taking a ketone supplement help with weight management a recent study? Find out in our article about supplements for weight management. Did supplementing with gymnema which may alter taste perception curb sugar cravings and reduce food intake in a recent study?

Find out in our updated CL Answer about supplements for reducing appetite and weight. Also see our CL Answer about supplements for blood sugar control to learn about use of gymnema in people with diabetes.

A CL Member asked if Spark Keto a. K3 Spark , can help with weight management. Find out what research suggests in the Appetite Suppressants section of our CL Answer about Supplements for Weight. Side effects : No side effects were noted in the clinical studies.

Getting enough protein from your diet is essential to help build and maintain muscle mass. Uses : Protein consumption, such as whey protein , has had the following effects. Dosage : The International Society of Sports Nutrition recommends that exercising individuals consume at least 1.

Average adults need around 0. Precautions : Caution should be taken if you have kidney or liver problems. Consult your healthcare provider or registered dietitian to determine the appropriate protein intake if you have kidney or liver problems.

Calcium and vitamin D are essential for the following:. Getting calcium from foods is generally better than getting it from supplements. Good food sources of calcium include the following:. Uses : One study examined the effect of milligrams mg of elemental calcium and vitamin D , using international units IU of vitamin D3, on people with the following characteristics.

Calcium and vitamin D supplementation for 12 weeks helped with fat loss. Moreover, researchers suggested that vitamin D deficiency increased appetite.

Dosage : The recommended daily amounts of calcium are as follows. Interactions : Calcium can interfere with the absorption of certain antibiotics, such as the following. Medications used for an underactive thyroid, such as Synthroid levothyroxine , also interact with calcium.

Consult your pharmacist about the appropriate timing of taking your medications and supplements. Vitamin D is best absorbed when taken with a healthy fat. Dosage : The recommended daily amounts of vitamin D are as follows. Interactions : Certain medications, such as Alli orlistat , can block the absorption of fat-soluble vitamins like vitamin D.

Getting enough vitamin D is important, particularly during darker months or at higher latitudes. Probiotics are the beneficial gut bacteria or yeast. Prebiotics are nondigestible fibers that support the growth of those microorganisms. Synbiotics refer to the combination of both probiotics and prebiotics.

Uses : Supplementation with synbiotics for three months increased the abundance of beneficial gut bacteria in people who are overweight or obese. Inulin , a type of fiber extracted from chicory, is a prebiotic that had the following effects in people with type 2 diabetes:.

However, the effects of inulin on weight and satiety in people who are overweight or have obesity but do not have diabetes are unclear. Dosage : The following dosages have been used in clinical studies. Side effects : Some side effects of probiotics and prebiotics include the following. Precautions : Some probiotics have caused infections in people with a compromised immune system.

Before taking probiotics, talk with your healthcare provider if you have a weakened immune system. Probiotics and prebiotics are safe during and after pregnancy and lactation.

Interactions : Antibiotics can decrease the effects of probiotics. As such, take probiotics at least two hours before or after antibiotics.

Green tea contains the catechin potent antioxidant epigallocatechingallate EGCG and caffeine. Uses : Green tea has been shown to have the following effects. The caffeine in green tea has been proposed to contribute to the following:.

Dosage : Green tea extract doses range from to mg per day by mouth. As green tea contains caffeine, it is advised that you limit your caffeine intake to no more than about mg if you are pregnant or breastfeeding.

Side effects : No side effects were reported in the studies. Precautions : Green tea may increase the risk of congenital disabilities caused by folic acid deficiency. Tea can also decrease iron absorption. You may want to avoid drinking it with your meals.

Liver problems have been reported with using green tea extract in pill form. If you have liver disease, consult a healthcare provider before taking products with green tea extract.

Interactions : Green tea and EGCG have decreased intestinal absorption—and thus, the therapeutic effects of—some of the following drugs. Animal studies indicate that green tea extract and EGCG increase the extent of absorption of the following drugs:.

However, human studies are needed to confirm these results. ALA is an antioxidant fatty acid that helps the body make energy from sugars. Uses : Preliminary evidence suggests ALA had the following effects.

Dosage : The dose of ALA ranges from to 2, mg per day by mouth. Side effects : Some of the side effects of ALA are as follows. Precautions should be taken in the following instances. Interactions : ALA may interact with the following medications.

Conjugated linoleic acid CLA is a polyunsaturated fatty acid found in the following foods:. Uses : A review suggested CLA had the following effects. While the effect of CLA on appetite is unclear, a review of a group of studies indicated that taking 3.

Overall, early evidence suggests that CLA could be used for treating obesity in addition to dietary modification. However, further research in humans is needed to confirm the results. Dosage : The dose used in clinical trials ranges from 1. Side effects : Most reported side effects were gastrointestinal side effects.

Precautions : Caution should be taken in people with the following conditions or characteristics. Interactions : Until more research is done on the drug interactions with CLA, it is unclear how CLA interacts with prescription and nonprescription medications.

Uses : Besides other amino acids in whey protein, tyrosine has had the following effects. However, outcomes from the study above are limited because it was conducted in only eight females with obesity. Further studies with a larger sample size and a more diverse population are needed.

Dosage : The specific amount of tyrosine was not explicitly stated in the study, but the dose of the whey protein powder was 45 g dissolved in milliliters mL of semi-skim milk.

More specifically, mL of the drink was given by mouth three times every five minutes. Interactions : Caution should be taken if you take the following medications. Uses : Bitter orange Citrus aurantium contains a chemical compound called p-synephrine, which is known to have the following effects.

Despite its popular use as an over-the-counter weight loss product, the quality of evidence is low to support the use of bitter orange for appetite control and weight loss in humans.

Dosage : The commonly used doses of p-synephrine range from 25 to mg per day by mouth. Precautions : Some studies have shown that bitter orange increased blood pressure and heart rate with long-term use i. Caution should be taken if you have high blood pressure, irregular heart rate, or other cardiovascular diseases.

The safety of bitter orange is unknown in the context of pregnancy or breastfeeding. Interactions : Bitter orange contains furanocoumarins, compounds that block the activity of the drug-metabolizing enzyme cytochrome P CYP 3A4.

Some studies show that bitter orange juice increases blood levels of drugs, such as Neoral cyclosporine and Invirase saquinavir , broken down by the CYP3A4 liver enzyme. DHEA is a hormone produced by the adrenal glands and the liver.

It serves as a precursor to sex hormones. DHEA dehydroepiandrosterone and 7-keto-DHEA are related but different. A limited number of studies suggests that 7-keto-DHEA , a form of DHEA, decreased body fat in people who are overweight or obese.

The mechanism behind the weight loss effect of 7-keto DHEA is due to its thermogenic effect, resulting in increased energy expenditure and increased metabolic rate. The dose of 7-keto DHEA used in clinical trials is mg per day by mouth.

Uses : One clinical study suggested DHEA favorably impacted body composition. Dosage : One study used mg per day of DHEA. Dosages may range between 25 mg and mg per day. Using DHEA at high doses i.

Precautions : Caution should be taken in the following situations. Interactions : DHEA may interact with some of the following medications. Some supplements that interact with DHEA include, but aren't limited to, the following:. In the United States, the Food and Drug Administration FDA does not regulate supplements the way it regulates prescription drugs.

That means some supplement products may not contain what the label says. When choosing a supplement , look for third-party tested products and consult a healthcare provider, registered dietitian nutritionist RD or RDN , or pharmacist.

There are no miracle dietary supplements that help with weight loss. Furthermore, weight loss supplements have been found to be contaminated with dangerous substances.

Their use is generally not advised. A sustainable approach to weight management best involves a balanced diet and getting regular exercise that you enjoy. Ephedra also known as má huáng is a stimulant that promotes weight loss by increasing thermogenesis and suppressing appetite.

However, the Food and Drug Administration FDA banned the use of ephedra in dietary supplements due to safety concerns. With the removal of ephedra from the market, bitter orange is commonly used as a substitute for ephedra due to the structural similarity between p-synephrine and ephedrine, the main component in the herb ephedra.

Despite the similarity in structure, p-synephrine acts differently from ephedra. Weight loss supplements can have side effects and interact with prescription drugs, over-the-counter drugs, and other dietary supplements.

Additionally, some products might be adulterated or tainted with prescription-drug ingredients.