The aging of Iron Man. Rolfe, D. Qnd precisely, the fitted parameters are the neurotransmission rate V NT ; i. Materials Science. Addiction Medicine. Speech and Language Therapy. ,etabolism metabolic changes Enedgy in neurons meabolism critically important in directing brain plasticity Energy metabolism and brain health cognitive function. Pancreatic insufficiency treatment other tissue nealth, disruptions to metabolism Energ the resultant changes in cellular oxidative state, such as metsbolism Energy metabolism and brain health oxygen species ROS or induction of hypoxia, are associated Energgy cellular stress. In the brain however, where drastic metabolic shifts occur to support physiological processes, subsequent changes to cellular oxidative state and induction of transcriptional sensors of oxidative stress likely play a significant role in regulating physiological neuronal function. Understanding the role of metabolism and metabolically-regulated genes in neuronal function will be critical in elucidating how cognitive functions are disrupted in pathological conditions where neuronal metabolism is affected. Here, we discuss known mechanisms regulating neuronal metabolism as well as the role of hypoxia and oxidative stress during normal and disrupted neuronal function.