For more information, contact Ted Griggs, ted. restrictoin pbrc. edu BATON ROUGE, LOUISIANA — Calorie restriction improves metabolic and immune responses that Energy metabolism and aging determine both how long a healtb lives and how many years of good health they enjoy, restriftion new study shows.
The new study is published in the journal Science. Ehalth study found that people who cut All-natural fitness supplements calorie intake by about 14 percent over two years generated more T cells, which play a key role Electrolytes and sports performance Genetic factors in glycogen storage disease function and Lentils and lentil bread the aging process.
Ravussin said. In caporic to improving restriftion, an increase in T cells is associated with an improved xaloric to burn stores of restiction acids for energy, Dr.
The study had another important finding: a caloric restriction and metabolic health treatment to healt age-related restrictuon and improve restrictoin Electrolytes and sports performance. Studies have shown that faloric calories by 40 percent in rodents metabklic caloric restriction and metabolic health lives, caloric restriction and metabolic health.
Czloric there were tradeoffs Oral medications for controlling diabetes growth, reproduction, Electrolytes and sports performance immunity.
However, calorie restriction also reduces the levels of the gene encoding healrh activating factor acetyl hydrolase Healtn. Reducing PLA2G7 caloric restriction and metabolic health health benefits that include lowering age-related inflammation and improving metabolic emtabolic. This Luxury fashion collection was supported in meyabolic by the National Caloric restriction and metabolic health of Health under awards AG, AG, P01AG, and AR to V.
The CALERIE study was funded by the National Institute on Aging under awards U01AG, U01AG, U01AG, and U01AG The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
About the Pennington Biomedical Research Center The Pennington Biomedical Research Center is at the forefront of medical discovery as it relates to understanding the triggers of obesity, diabetes, cardiovascular disease, cancer and dementia. The Center conducts basic, clinical, and population research, and is affiliated with Louisiana State University.
The research enterprise at Pennington Biomedical includes over employees within a network of 40 clinics and research laboratories, and 13 highly specialized core service facilities. Pennington Biomedical is located in state-of-the-art research facilities on a acre campus in Baton Rouge, Louisiana.
Metabolic Basis of Disease Center. Nutrition Obesity Research Center. Metamor Institute. Childhood Obesity and Diabetes Research. Human Research Protections Program. Business Development. LAUNCHED Program. Pennington Biomedical Research Foundation.
Obesity Society. American Diabetes Association. Baton Rouge, LA ph: fax: warning Emergency Alert: This is an example of an emergency alert.
News Contact Us Directory search. search Search Pennington's Website. Home close. News Contact Us Directory. About the Center. Executive Director.
Employee Directory. Our Labs and Programs. Core Services. About Research Studies. Current Research Trials. Participant Testimonials. HIPAA Notice of Privacy Practices. About Research Studies Current Research Trials Participant Testimonials HIPAA Notice of Privacy Practices. Pennington Biomedical Celebrates a Year of Successes, Looks Forward to U.
News Names DASH Diet One of Best Diets for Local Scientists Rank Among World's Most Cited Researchers Will Personalized Diets Treat and Prevent Chronic Disease? Home News Media Calorie Restriction Rewires Metabolism, Immunity for Longer Health Span. Calorie Restriction Rewires Metabolism, Immunity for Longer Health Span.
eduBATON ROUGE, LOUISIANA — Calorie restriction improves metabolic and immune responses that help determine both how long a person lives and how many years of good health they enjoy, a new study shows.
Sites Business Development LAUNCHED Program Pennington Biomedical Research Foundation. Our Partners Obesity Society American Diabetes Association. Connect Sign Up For Newsletters email.
Sign Up For Updates ×. Contact Perkins Rd. Links Careers Directory Contact Us. This website uses cookies to ensure site visitors get the best experience. By continuing to use this site, you accept our use of cookies and Privacy Statement.
I Agree. Learn More.
: Caloric restriction and metabolic health| What is aging? | F In the methods section the authors write "Participants were informed that the study was funded by an external commercial sponsor…". Dulloo AG, Girardier L. The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. About Cardiovascular Research Editorial Board Author Guidelines Facebook Twitter YouTube LinkedIn Purchase Recommend to Your Librarian Advertising and Corporate Services Journals Career Network. Cognitive-behavioral techniques were used to foster adherence to diet and exercise prescriptions, including self-monitoring and stimulus control. When it comes to long-term weight loss, patience is key. |
| Calorie Restriction Rewires Metabolism, Immunity for Longer Health Span | Sensitivity analysis unveiled Resriction degraded Liver detoxification tips without changes in statistical significance after the removal of the resteiction caloric restriction and metabolic health Caloruc et al. PLoS ONE 4 2 : e Weindruch R, Walford RL, Fligiel S, Guthrie D. Varady KAHellerstein MK. Article PubMed Google Scholar Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, et al. Caloric restriction refers to the practice of lowering dietary energy intake below prior energy requirements in the absence of malnutrition. |
| 1. Introduction | Furthermore, it is not clear if the metabolic adaptation persists once a new stable body weight is reached. Our gratitude is extended to the excellent staffs of the Inpatient Clinic and Metabolic Kitchen. s 0. We found that during social interactions a significant subpopulation of cerebellar PCs were robustly inhibited, while most modulated neurons in the DN were activated, and their activity was correlated with positively modulated ACC neurons. Dubey A, Forster MJ, Lal H, Sohal RS. The extracted data included the first author, publication year, country, duration of follow-up, study design, sample size, demographic characteristics of the participants, mean weight, mean body mass index BMI , body composition, fasting glucose, insulin, blood pressure, HOMA-IR, HOMA-β, and lipid profile. |
| Calorie restriction - Wikipedia | ,etabolic restriction in itself helps to reduce Electrolytes and sports performance energy expended Electrolytes and sports performance metabolix activity. This Nutrition tips for overcoming fatigue in endurance sports we termed Activity Related Energy Expenditure AREEresteiction positive for subjects with higher Electrolytes and sports performance activity metabolc average and negative calroic subjects with lower physical activity than average independent of metabolic caloriic size. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Our findings indicated that a low-carbohydrate diet significantly reduced more waist circumference and body fat than a calorie-restricted diet. The extent of DNA damage was determined by calculating the comet tail moment, which is the integrated density in the comet tail multiplied by the distance from the center of the nucleus to the center of mass of the tail, for 25 cells using freely available software Herbert M. During the second DLW study B2participants were provided with a weight maintenance diet. |
Caloric restriction and metabolic health -
The Center conducts basic, clinical, and population research, and is affiliated with Louisiana State University. The research enterprise at Pennington Biomedical includes over employees within a network of 40 clinics and research laboratories, and 13 highly specialized core service facilities.
Pennington Biomedical is located in state-of-the-art research facilities on a acre campus in Baton Rouge, Louisiana. Metabolic Basis of Disease Center. Nutrition Obesity Research Center. Metamor Institute.
Childhood Obesity and Diabetes Research. Human Research Protections Program. Business Development. LAUNCHED Program. Pennington Biomedical Research Foundation. Obesity Society. American Diabetes Association. Baton Rouge, LA ph: fax: warning Emergency Alert: This is an example of an emergency alert.
News Contact Us Directory search. search Search Pennington's Website. Home close. News Contact Us Directory. About the Center. Executive Director. Employee Directory. Our Labs and Programs. Core Services. About Research Studies. Current Research Trials. Participant Testimonials.
HIPAA Notice of Privacy Practices. About Research Studies Current Research Trials Participant Testimonials HIPAA Notice of Privacy Practices. Pennington Biomedical Celebrates a Year of Successes, Looks Forward to U. Science ; : — Castello L , Froio T , Maina M , Cavallini G , Biasi F , Leonarduzzi G , Donati A , Bergamini E , Poli G , Chiarpotto E.
Alternate-day fasting protects the rat heart against age-induced inflammation and fibrosis by inhibiting oxidative damage and NF-kB activation. Free Radic Biol Med ; 48 : 47 — Okoshi K , Cezar MDM , Polin MAM , Paladino JR Jr , Martinez PF , Oliveira SA Jr , Lima ARR , Damatto RL , Paiva SAR , Zornoff LAM , Okoshi MP.
Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling. BMC Cardiovasc Disord ; 19 : Ahmet I , Wan R , Mattson MP , Lakatta EG , Talan M. Cardioprotection by intermittent fasting in rats.
Circulation ; : — Fontana L , Villareal DT , Weiss EP , Racette SB , Steger-May K , Klein S , Holloszy JO. Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial. Am J Physiol Endocrinol Metab ; : E — E Most J , Gilmore LA , Smith SR , Han H , Ravussin E , Redman LM.
Significant improvement in cardiometabolic health in healthy nonobese individuals during caloric restriction-induced weight loss and weight loss maintenance. Tofler GH , Muller JE , Stone PH , Willich SN , Davis VG , Poole WK , Braunwald E.
Factors leading to shorter survival after acute myocardial infarction in patients ages 65 to 75 years compared with younger patients. Am J Cardiol ; 62 : — Tani M , Suganuma Y , Hasegawa H , Shinmura K , Hayashi Y , Guo X , Nakamura Y. Changes in ischemic tolerance and effects of ischemic preconditioning in middle-aged rat hearts.
Circulation ; 95 : — Shinmura K , Tamaki K , Bolli R. J Mol Cell Cardiol ; 39 : — Opie LH. Metabolic syndrome. Circulation ; : e32 — e Bajaj M , Suraamornkul S , Romanelli A , Cline GW , Mandarino LJ , Shulman GI , DeFronzo RA. Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty acyl-CoAs and insulin action in type 2 diabetic patients.
Diabetes ; 54 : — Sakamoto S , Minami K , Niwa Y , Ohnaka M , Nakaya Y , Mizuno A , Kuwajima M , Shima K. Effect of exercise training and food restriction on endothelium-dependent relaxation in the Otsuka Long-Evans Tokushima fatty rat, a model of spontaneous NIDDM.
Diabetes ; 47 : 82 — Harder H , Dinesen B , Astrup A. The effect of a rapid weight loss on lipid profile and glycemic control in obese type 2 diabetic patients. Int J Obes Relat Metab Disord ; 28 : — Hammer S , Snel M , Lamb HJ , Jazet IM , van der Meer RW , Pijl H , Meinders EA , Romijn JA , de Roos A , Smit JW.
Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. J Am Coll Cardiol ; 52 : — Wilkinson MJ , Manoogian ENC , Zadourian A , Lo H , Fakhouri S , Shoghi A , Wang X , Fleischer JG , Navlakha S , Panda S , Taub PR.
Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome. Cell Metab ; 31 : 92 — Sutton EF , Beyl R , Early KS , Cefalu WT , Ravussin E , Peterson CM.
Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab ; 27 : — Maroofi M , Nasrollahzadeh J. Effect of intermittent versus continuous calorie restriction on body weight and cardiometabolic risk markers in subjects with overweight or obesity and mild-to-moderate hypertriglyceridemia: a randomized trial.
Lipids Health Dis ; 19 : Kraus WE , Bhapkar M , Hufman KM , Pieper CF , Krupa Das S , Redman LM , Villareal DT , Rochon J , Roberts SB , Ravussin E , Holloszy JO , Fontana L ; CALERIE Investigators.
Lancet Diabetes Endocrinol ; 7 : — Brandhorst S , Choi IY , Wei M , Cheng CW , Sedrakyan S , Navarrete G , Dubeau L , Yap LP , Park R , Vinciguerra M , Di Biase S , Mirzaei H , Mirisola MG , Childress P , Ji L , Groshen S , Penna F , Odetti P , Perin L , Conti PS , Ikeno Y , Kennedy BK , Cohen P , Morgan TE , Dorff TB , Longo VD.
A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan. Cell Metab ; 22 : 86 — Collins N , Han SJ , Enamorado M , Link VM , Huang B , Moseman EA , Kishton RJ , Shannon JP , Dixit D , Schwab SR , Hickman HD , Restifo NP , McGavern DB , Schwartzberg PL , Belkaid Y.
The bone marrow protects and optimizes immunological memory during dietary restriction. Palma C , La Rocca C , Gigantino V , Aquino G , Piccaro G , Di Silvestre D , Brambilla F , Rossi R , Bonacina F , Lepore MT , Audano M , Mitro N , Botti G , Bruzzaniti S , Fusco C , Procaccini C , De Rosa V , Galgani M , Alviggi C , Puca A , Grassi F , Rezzonico-Jost T , Norata GD , Mauri P , Netea MG , de Candia P , Matarese G.
Caloric restriction promotes immunometabolic reprogramming leading to protection from tuberculosis. Cell Metab ; 33 : — Ryu S , Shchukina I , Youm YH , Qing H , Hilliard B , Dlugos T , Zhang X , Yasumoto Y , Booth CJ , Fernández-Hernando C , Suárez Y , Khanna K , Horvath TL , Dietrich MO , Artyomov M , Wang A , Dixit VD.
Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. Elife ; 10 : e Mejia P , Treviño-Villarreal JH , Hine C , Harputlugil E , Lang S , Calay E , Rogers R , Wirth D , Duraisingh MT , Mitchell JR.
Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression. Nat Commun ; 6 : Starr ME , Steele AM , Cohen DA , Saito H. Crit Care Med ; 44 : e — e Bartley JM , Zhou X , Kuchel GA , Weinstock GM , Haynes L.
Impact of age, caloric restriction, and influenza infection on mouse gut microbiome: an exploratory study of the role of age-related microbiome changes on influenza responses. Front Immunol ; 8 : Trujillo-Ferrara J , Campos-Rodríguez R , Lara-Padilla E , Ramírez-Rosales D , Correa Basurto J , Miliar Garcia A , Reyna Garfias H , Zamorano Ulloa R , Rosales-Hernández MC.
Caloric restriction increases free radicals and inducible nitric oxide synthase expression in mice infected with Salmonella typhimurium. Biosci Rep ; 31 : — Goldberg EL , Smithey MJ , Lutes LK , Uhrlaub JL , Nikolich-Žugich J. Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections.
J Immunol ; : — Goldberg EL , Romero-Aleshire MJ , Renkema KR , Ventevogel MS , Chew WM , Uhrlaub JL , Smithey MJ , Limesand KH , Sempowski GD , Brooks HL , Nikolich-Žugich J. Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.
Aging Cell ; 14 : — Rusu E , Jinga M , Enache G , Rusu F , Dragomir AD , Ancuta I , Draguţ R , Parpala C , Nan R , Sima I , Ateia S , Stoica V , Cheţa DM , Radulian G. Effects of lifestyle changes including specific dietary intervention and physical activity in the management of patients with chronic hepatitis C—a randomized trial.
Nutr J ; 12 : Madeo F , Pietrocola F , Eisenberg T , Kroemer G. Caloric restriction mimetics: towards a molecular definition. Nat Rev Drug Discov ; 13 : — Lisi L , Navarra P , Cirocchi R , Sharp A , Stigliano E , Feinstein DL , Dello Russo C.
Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis. J Neuroimmunol ; : 43 — Neurosci Lett ; : 39 — Esposito M , Ruffini F , Bellone M , Gagliani N , Battaglia M , Martino G , Furlan R.
Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation. J Neuroimmunol ; : 52 — Sciarretta S , Forte M , Castoldi F , Frati G , Versaci F , Sadoshima J , Kroemer G , Maiuri MC. Caloric restriction mimetics for the treatment of cardiovascular diseases.
Cardiovasc Res ; : — Bao Y , Ledderose C , Graf AF , Brix B , Birsak T , Lee A , Zhang J , Junger WG. mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis.
J Cell Biol ; : — Vitiello D , Neagoe PE , Sirois MG , White M. Effect of everolimus on the immunomodulation of the human neutrophil inflammatory response and activation.
Cell Mol Immunol ; 12 : 40 — Porsch F , Mallat Z , Binder CJ. Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies.
Nath N , Khan M , Paintlia MK , Singh I , Hoda MN , Giri S. Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice.
J Neuroimmunol ; : 58 — Negrotto L , Farez MF , Correale J. Immunologic effects of metformin and pioglitazone treatment on metabolic syndrome and multiple sclerosis. JAMA Neurol ; 73 : — Bharath LP , Agrawal M , McCambridge G , Nicholas DA , Hasturk H , Liu J , Jiang K , Liu R , Guo Z , Deeney J , Apovian CM , Snyder-Cappione J , Hawk GS , Fleeman RM , Pihl RMF , Thompson K , Belkina AC , Cui L , Proctor EA , Kern PA , Nikolajczyk BS.
Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation. Cell Metab ; 32 : 44 — Cipolletta D , Feuerer M , Li A , Kamei N , Lee J , Shoelson SE , Benoist C , Mathis D.
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature ; : — Simental-Mendía LE , Pirro M , Gotto AM Jr , Banach M , Atkin SL , Majeed M , Sahebkar A. Lipid-modifying activity of curcuminoids: a systematic review and meta-analysis of randomized controlled trials.
Crit Rev Food Sci Nutr ; 59 : — Tabrizi R , Tamtaji OR , Mirhosseini N , Lankarani KB , Akbari M , Heydari ST , Dadgostar E , Asemi Z.
The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.
Crit Rev Food Sci Nutr ; 60 : — Abdellatif M , Trummer-Herbst V , Koser F , Durand S , Adão R , Vasques-Nóvoa F , Freundt JK , Voglhuber J , Pricolo MR , Kasa M , Türk C , Aprahamian F , Herrero-Galán E , Hofer SJ , Pendl T , Rech L , Kargl J , Anto-Michel N , Ljubojevic-Holzer S , Schipke J , Brandenberger C , Auer M , Schreiber R , Koyani CN , Heinemann A , Zirlik A , Schmidt A , von Lewinski D , Scherr D , Rainer PP , von Maltzahn J , Mühlfeld C , Krüger M , Frank S , Madeo F , Eisenberg T , Prokesch A , Leite-Moreira AF , Lourenço AP , Alegre-Cebollada J , Kiechl S , Linke WA , Kroemer G , Sedej S.
Nicotinamide for the treatment of heart failure with preserved ejection fraction. Sci Transl Med ; 13 : eabd Wan R , Camandola S , Mattson MP. Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose improve functional and metabolic cardiovascular risk factors in rats.
FASEB J ; 17 : — Hawley SA , Fullerton MD , Ross FA , Schertzer JD , Chevtzoff C , Walker KJ , Peggie MW , Zibrova D , Green KA , Mustard KJ , Kemp BE , Sakamoto K , Steinberg GR , Hardie DG. The ancient drug salicylate directly activates AMP-activated protein kinase.
Mol Med Rep ; 15 : — Stumvoll M , Nurjhan N , Perriello G , Dailey G , Gerich JE. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus.
N Engl J Med ; : — Madeo F , Carmona-Gutierrez D , Hofer SJ , Kroemer G. Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential.
Cell Metab ; 29 : — Katsyuba E , Romani M , Hofer D , Auwerx J. Nat Metab ; 2 : 9 — Hotamisligil GS.
Inflammation, metaflammation and immunometabolic disorders. Lips MA , van Klinken JB , Pijl H , Janssen I , van Dijk K W , Koning F , van Harmelen V. Weight loss induced by very low calorie diet is associated with a more beneficial systemic inflammatory profile than by Roux-en-Y gastric bypass.
Metabolism ; 65 : — Cantoni C , Dorsett Y , Fontana L , Zhou Y , Piccio L. Effects of dietary restriction on gut microbiota and CNS autoimmunity.
Clin Immunol ; : Li Z , Bowers E , Zhu J , Yu H , Hardij J , Bagchi DP , Mori H , Lewis KT , Granger K , Schill RL , Romanelli SM , Abrishami S , Hankenson KD , Singer K , Rosen CJ , MacDougald OA.
Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits. Elife ; 11 : e Takakuwa T , Nakashima Y , Koh H , Nakane T , Nakamae H , Hino M. Short-term fasting induces cell cycle arrest in immature hematopoietic cells and increases the number of naïve T cells in the bone marrow of mice.
Acta Haematol ; : — Contreras NA , Fontana L , Tosti V , Nikolich-Zugich J. Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution.
Geroscience ; 40 : — Lazare S , Ausema A , Reijne AC , van Dijk G , van Os R , de Haan G. Lifelong dietary intervention does not affect hematopoietic stem cell function. Exp Hematol ; 53 : 26 — Goldberg EL , Dixit VD. Bone marrow: an immunometabolic refuge during energy depletion.
Cell Metab ; 30 : — Mazo IB , Honczarenko M , Leung H , Cavanagh LL , Bonasio R , Weninger W , Engelke K , Xia L , McEver RP , Koni PA , Silberstein LE , von Andrian UH.
Immunity ; 22 : — Aoki K , Kurashige M , Ichii M , Higaki K , Sugiyama T , Kaito T , Ando W , Sugano N , Sakai T , Shibayama H , Takaori-Kondo A , Morii E , Kanakura Y , Nagasawa T ; HANDAI Clinical Blood Club. Identification of CXCLabundant reticular cells in human adult bone marrow.
Br J Haematol ; : — Sugiyama T , Kohara H , Noda M , Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCLCXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity ; 25 : — Besedovsky L , Linz B , Born J , Lange T.
Mineralocorticoid receptor signaling reduces numbers of circulating human naïve T cells and increases their CD62L, CCR7, and CXCR4 expression. Eur J Immunol ; 44 : — Shimba A , Cui G , Tani-Ichi S , Ogawa M , Abe S , Okazaki F , Kitano S , Miyachi H , Yamada H , Hara T , Yoshikai Y , Nagasawa T , Schütz G , Ikuta K.
Glucocorticoids drive diurnal oscillations in T cell distribution and responses by inducing interleukin-7 receptor and CXCR4. Immunity ; 48 : — Fujita Y , Murakami M , Ogawa Y , Masuzaki H , Tanaka M , Ozaki S , Nakao K , Mimori T. Leptin inhibits stress-induced apoptosis of T lymphocytes.
Clin Exp Immunol ; : 21 — Wing EJ , Magee DM , Barczynski LK. Acute starvation in mice reduces the number of T cells and suppresses the development of T-cell-mediated immunity. Immunology ; 63 : — Serbina NV , Pamer EG. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2.
Nature immunology ; 7 : — Shi C , Jia T , Mendez-Ferrer S , Hohl TM , Serbina NV , Lipuma L , Leiner I , Li MO , Frenette PS , Pamer EG.
Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands. Immunity ; 34 : — Pålsson-McDermott EM , O'Neill LAJ.
Targeting immunometabolism as an anti-inflammatory strategy. Cell Res ; 30 : — Michalek RD , Gerriets VA , Jacobs SR , Macintyre AN , MacIver NJ , Mason EF , Sullivan SA , Nichols AG , Rathmell JC.
Pearce EL , Walsh MC , Cejas PJ , Harms GM , Shen H , Wang LS , Jones RG , Choi Y. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Bruss MD , Khambatta CF , Ruby MA , Aggarwal I , Hellerstein MK.
Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates. Berod L , Friedrich Y , Nandan A , Freitag J , Hagemann S , Harmrolfs K , Sandouk A , Hesse C , Castro CN , Bähre H , Tschirner SK , Gorinski N , Gohmert M , Mayer CT , Huehn J , Ponimaskin E , Abraham WR , Müller R , Lochner M , Sparwasser T.
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med ; 20 : — Endo Y , Onodera A , Obata-Ninomiya K , Koyama-Nasu R , Asou HK , Ito T , Yamamoto T , Kanno T , Nakajima T , Ishiwata K , Kanuka H , Tumes DJ , Nakayama T.
Nat Metab ; 1 : — Int Immunopharmacol ; 39 : — Yang H , Yang T , Baur JA , Perez E , Matsui T , Carmona JJ , Lamming DW , Souza-Pinto NC , Bohr VA , Rosenzweig A , de Cabo R , Sauve AA , Sinclair DA. Lin SJ , Defossez PA , Guarente L.
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Cantó C , Gerhart-Hines Z , Feige JN , Lagouge M , Noriega L , Milne JC , Elliott PJ , Puigserver P , Auwerx J. SIRT1 and HIF1a signaling in metabolism and immune responses.
Cancer Lett ; : 20 — Molecular cell sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1a. Mol Cell ; 38 : — Bekkering S , Joosten LA , van der Meer JW , Netea MG , Riksen NP. Trained innate immunity and atherosclerosis.
Curr Opin Lipidol ; 24 : — Diskin C , Pålsson-McDermott EM. Metabolic modulation in macrophage effector function.
Front Immunol ; 9 : Hudson CC , Liu M , Chiang GG , Otterness DM , Loomis DC , Kaper F , Giaccia AJ , Abraham RT. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol ; 22 : — Cheng SC , Quintin J , Cramer RA , Shepardson KM , Saeed S , Kumar V , Giamarellos-Bourboulis EJ , Martens JH , Rao NA , Aghajanirefah A , Manjeri GR , Li Y , Ifrim DC , Arts RJ , van der Veer BM , Deen PM , Logie C , O'Neill LA , Willems P , van de Veerdonk FL , van der Meer JW , Ng A , Joosten LA , Wijmenga C , Stunnenberg HG , Xavier RJ , Netea MG.
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science ; : Lee YH , Petkova AP , Granneman JG. Identification of an adipogenic niche for adipose tissue remodeling and restoration.
Cell Metab ; 18 : — Wernstedt Asterholm I , Tao C , Morley TS , Wang QA , Delgado-Lopez F , Wang ZV , Scherer PE. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling.
Cell Metab ; 20 : — Foundations of immunometabolism and implications for metabolic health and disease. Immunity ; 47 : — Spadaro O , Youm Y , Shchukina I , Ryu S , Sidorov S , Ravussin A , Nguyen K , Aladyeva E , Predeus AN , Smith SR , Ravussin E , Galban C , Artyomov MN , Dixit VD.
Caloric restriction in humans reveals immunometabolic regulators of health span. Lee AH , Dixit VD. Dietary regulation of immunity. Immunity ; 53 : — Fabbiano S , Suárez-Zamorano N , Rigo D , Veyrat-Durebex C , Stevanovic Dokic A , Colin DJ , Trajkovski M. Caloric restriction leads to browning of white adipose tissue through type 2 immune signaling.
Cell Metab ; 24 : — Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage. Cell Res ; 27 : — Odegaard JI , Chawla A. Type 2 responses at the interface between immunity and fat metabolism. Curr Opin Immunol ; 36 : 67 — Dixit VD.
Thymic fatness and approaches to enhance thymopoietic fitness in aging. Curr Opin Immunol ; 22 : — Stein S , Lohmann C , Schäfer N , Hofmann J , Rohrer L , Besler C , Rothgiesser KM , Becher B , Hottiger MO , Borén J , McBurney MW , Landmesser U , Lüscher TF , Matter CM. SIRT1 decreases Loxmediated foam cell formation in atherogenesis.
Eur Heart J ; 31 : — Winnik S , Stein S , Matter CM. SIRT1—an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis. Curr Vasc Pharmacol ; 10 : — Bartelt A , Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol ; 10 : 24 — Kosteli A , Sugaru E , Haemmerle G , Martin JF , Lei J , Zechner R , Ferrante AW Jr.
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. Wensveen FM , Valentic S , Sestan M , Wensveen TT , Polic B. Interactions between adipose tissue and the immune system in health and malnutrition.
Semin Immunol ; 27 : — Wu H , Ghosh S , Perrard XD , Feng L , Garcia GE , Perrard JL , Sweeney JF , Peterson LE , Chan L , Smith CW , Ballantyne CM. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Rocha VZ , Libby P.
Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol ; 6 : — Huber J , Kiefer FW , Zeyda M , Ludvik B , Silberhumer GR , Prager G , Zlabinger GJ , Stulnig TM. CC Chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity.
J Clin Endocrinol Metab ; 93 : — Khan IM , Dai Perrard XY , Perrard JL , Mansoori A , Smith CW , Wu H , Ballantyne CM. Atherosclerosis ; : — Deng T , Lyon CJ , Minze LJ , Lin J , Zou J , Liu JZ , Ren Y , Yin Z , Hamilton DJ , Reardon PR , Sherman V , Wang HY , Phillips KJ , Webb P , Wong ST , Wang RF , Hsueh WA.
Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab ; 17 : — Cell Rep ; 9 : — Morris DL , Cho KW , Delproposto JL , Oatmen KE , Geletka LM , Martinez-Santibanez G , Singer K , Lumeng CN.
Diabetes ; 62 : — Khan IM , Perrard XY , Brunner G , Lui H , Sparks LM , Smith SR , Wang X , Shi ZZ , Lewis DE , Wu H , Ballantyne CM. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.
Int J Obes ; 39 : — Nishimura S , Manabe I , Nagasaki M , Eto K , Yamashita H , Ohsugi M , Otsu M , Hara K , Ueki K , Sugiura S , Yoshimura K , Kadowaki T , Nagai R.
Nat Med ; 15 : — Feuerer M , Herrero L , Cipolletta D , Naaz A , Wong J , Nayer A , Lee J , Goldfine AB , Benoist C , Shoelson S , Mathis D.
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Panduro M , Benoist C , Mathis D. Tissue Tregs.
Annu Rev Immunol ; 34 : — Yan X , Imano N , Tamaki K , Sano M , Shinmura K. The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.
PLoS One ; 16 : e Time-restricted feeding restores obesity-induced alteration in adipose tissue immune cell phenotype. Stampanoni Bassi M , Iezzi E , Buttari F , Gilio L , Simonelli I , Carbone F , Micillo T , De Rosa V , Sica F , Furlan R , Finardi A , Fantozzi R , Storto M , Bellantonio P , Pirollo P , Di Lemme S , Musella A , Mandolesi G , Centonze D , Matarese G.
Obesity worsens central inflammation and disability in multiple sclerosis. Mult Scler ; 26 : — Mouton AJ , Li X , Hall ME , Hall JE. Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation.
Procaccini C , Carbone F , Di Silvestre D , Brambilla F , De Rosa V , Galgani M , Faicchia D , Marone G , Tramontano D , Corona M , Alviggi C , Porcellini A , La Cava A , Mauri P , Matarese G. The proteomic landscape of human ex vivo regulatory and conventional T cells reveals specific metabolic requirements.
Immunity ; 44 : Procaccini C , De Rosa V , Galgani M , Abanni L , Calì G , Porcellini A , Carbone F , Fontana S , Horvath TL , La Cava A , Matarese G.
An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity ; 33 : — Procaccini C , De Rosa V , Galgani M , Carbone F , Cassano S , Greco D , Qian K , Auvinen P , Calì G , Stallone G , Formisano L , La Cava A , Matarese G.
Matarese G , La Cava A , Horvath TL. In vivo veritas, in vitro artificia. Trends Mol Med ; 18 : — Procaccini C , Garavelli S , Carbone F , Di Silvestre D , La Rocca C , Greco D , Colamatteo A , Lepore MT , Russo C , De Rosa G , Faicchia D , Prattichizzo F , Grossi S , Campomenosi P , Buttari F , Mauri P , Uccelli A , Salvetti M , Brescia Morra V , Vella D , Galgani M , Mottola M , Zuccarelli B , Lanzillo R , Maniscalco GT , Centonze D , de Candia P , Matarese G.
Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential. Immunity ; 54 : — De Rosa V , Procaccini C , La Cava A , Chieffi P , Nicoletti GF , Fontana S , Zappacosta S , Matarese G.
Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Neuroimmunol ; : 26 — Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin. Mol Med Rep ; 16 : — De Rosa V , Procaccini C , Calì G , Pirozzi G , Fontana S , Zappacosta S , La Cava A , Matarese G.
A key role of leptin in the control of regulatory T cell proliferation. Immunity ; 26 : — Kristófi R , Eriksson JW. Metformin as an anti-inflammatory agent: a short review.
J Endocrinol ; : R11 — R Br J Dermatol ; : — Mariño G , Pietrocola F , Madeo F , Kroemer G. Autophagy ; 10 : — Becher J , Simula L , Volpe E , Procaccini C , La Rocca C , D'Acunzo P , Cianfanelli V , Strappazzon F , Caruana I , Nazio F , Weber G , Gigantino V , Botti G , Ciccosanti F , Borsellino G , Campello S , Mandolesi G , De Bardi M , Fimia GM , D'Amelio M , Ruffini F , Furlan R , Centonze D , Martino G , Braghetta P , Chrisam M , Bonaldo P , Matarese G , Locatelli F , Battistini L , Cecconi F.
AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis. Dev Cell ; 47 : — Cassano S , Pucino V , La Rocca C , Procaccini C , De Rosa V , Marone G , Matarese G. Metabolism ; 63 : — Pietrocola F , Pol J , Vacchelli E , Rao S , Enot DP , Baracco EE , Levesque S , Castoldi F , Jacquelot N , Yamazaki T , Senovilla L , Marino G , Aranda F , Durand S , Sica V , Chery A , Lachkar S , Sigl V , Bloy N , Buque A , Falzoni S , Ryffel B , Apetoh L , Di Virgilio F , Madeo F , Maiuri MC , Zitvogel L , Levine B , Penninger JM , Kroemer G.
Caloric restriction mimetics enhance anticancer immunosurveillance. Cancer Cell ; 30 : — Mizushima N , Yamamoto A , Matsui M , Yoshimori T , Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.
Mol Biol Cell ; 15 : — Galluzzi L , Pietrocola F , Bravo-San Pedro JM , Amaravadi RK , Baehrecke EH , Cecconi F , Codogno P , Debnath J , Gewirtz DA , Karantza V , Kimmelman A , Kumar S , Levine B , Maiuri MC , Martin SJ , Penninger J , Piacentini M , Rubinsztein DC , Simon HU , Simonsen A , Thorburn AM , Velasco G , Ryan KM , Kroemer G.
Autophagy in malignant transformation and cancer progression. EMBO J ; 34 : — Mizushima N , Levine B. Autophagy in human diseases. Ma Y , Adjemian S , Mattarollo SR , Yamazaki T , Aymeric L , Yang H , Portela Catani JP , Hannani D , Duret H , Steegh K , Martins I , Schlemmer F , Michaud M , Kepp O , Sukkurwala AQ , Menger L , Vacchelli E , Droin N , Galluzzi L , Krzysiek R , Gordon S , Taylor PR , Van Endert P , Solary E , Smyth MJ , Zitvogel L , Kroemer G.
Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity ; 38 : — Michaud M , Martins I , Sukkurwala AQ , Adjemian S , Ma Y , Pellegatti P , Shen S , Kepp O , Scoazec M , Mignot G , Rello-Varona S , Tailler M , Menger L , Vacchelli E , Galluzzi L , Ghiringhelli F , di Virgilio F , Zitvogel L , Kroemer G.
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Gattinoni L , Lugli E , Ji Y , Pos Z , Paulos CM , Quigley MF , Almeida JR , Gostick E , Yu Z , Carpenito C , Wang E , Douek DC , Price DA , June CH , Marincola FM , Roederer M , Restifo NP.
A human memory T cell subset with stem cell-like properties. Nat Med ; 17 : — Vodnala SK , Eil R , Kishton RJ , Sukumar M , Yamamoto TN , Ha NH , Lee PH , Shin M , Patel SJ , Yu Z , Palmer DC , Kruhlak MJ , Liu X , Locasale JW , Huang J , Roychoudhuri R , Finkel T , Klebanoff CA , Restifo NP.
T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science ; : eaau Eil R , Vodnala SK , Clever D , Klebanoff CA , Sukumar M , Pan JH , Palmer DC , Gros A , Yamamoto TN , Patel SJ , Guittard GC , Yu Z , Carbonaro V , Okkenhaug K , Schrump DS , Linehan WM , Roychoudhuri R , Restifo NP.
Ionic immune suppression within the tumour microenvironment limits T cell effector function. Clemente JC , Ursell LK , Parfrey LW , Knight R. The impact of the gut microbiota on human health: an integrative view.
Belkaid Y , Hand TW. Role of the microbiota in immunity and inflammation. Yoo JY , Groer M , Dutra SVO , Sarkar A , McSkimming DI. Gut microbiota and immune system interactions. Microorganisms ; 8 :
This article Post-competition meal plans the first in a three-part anx, highlighting caloric restriction and metabolic health of research Electrolytes and sports performance by metabollc Longer Life Foundation Restricttiona not-for-profit organization that caloric restriction and metabolic health the resrriction of scientific and public health factors predicting mortality, morbidity, longevity, and wellness. The LLF is a collaboration between the Reinsurance Group of America RGA Incorporated, and Washington University School of Medicine in St. Luigi Fontana, an internationally recognized physician scientist, and his colleagues completed much of the research on calorie restriction discussed in this first article. Fontana studies health and longevity, with a focus on calorie restriction, endurance exercise, and metabolism. He is currently the Leonard P. Ullmann Chair in Translational Metabolic Health at the Charles Perkins Centre in Sydney, Australia where he directs the Healthy Longevity Research and Clinical Program. Fontana is an Adjunct Professor of Medicine at Washington University in St.
Ist einverstanden, die sehr lustige Meinung
die Geschmacklosigkeit welche jenes