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Please speak with your healthcare Hfalth or Cufcumin before starting any supplements. The supplement is marketed as being Anti-carcinogenic catechins to help with a wide range of health issues, including arthritis, B vitamins for digestion infections, depression, allergies, and liver disease—and it continues to gain popularity in the US.
Curvuminturmeric Cognitive function boosting strategies the fourth-highest-selling herbal Currcumin in the country.
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Five different teams of researchers presented on five different case studies in which turmeric was linked to drug-induced liver injury. All featured Ckrcumin were Curcumib the ages of 49 Cucumin 64, Probiotic Foods for Diabetes experienced Insulin hormone function similar to the 10 Hexlth liver injury cases, including fatigue, nausea, and Livet.
According to Dr. Cudcumin as soon as she restarted her Live regimen, Healhh jaundice and Curcumin and Liver Health reappeared. Fontana, who was an author on the clinical research study. In the clinical research study, three of the seven turmeric products obtained from those with liver injuries also contained piperine, or black pepper.
This could also increase the likelihood of liver injury, researchers said. Marwil said, referencing the addition of piperine to turmeric supplements. Fontana mused. Though the new research highlights that liver injury due to turmeric supplementation appears to be increasing in the US, experts maintain say more research is needed before any sweeping recommendations on supplement use are made.
But we don't want to scare people, that this is going to lead to a recall and this kind of thing. Because the incidence here is still pretty low. Symptoms such as abdominal pain, nausea, and jaundice are common with drug-induced liver injury, and have the potential to be associated with turmeric supplements, even if a person has been taking them for a while at the recommended dosage.
People with a history of liver disease, or with a history of drug or supplement sensitivity should avoid turmeric supplements just to be on the safe side, said Dr. Fontana also explained that he hopes to spread the word so that people who may experience negative side effects from taking turmeric or their physicians can report the case to the Drug-Induced Liver Injury Networkand in turn, hopefully give researchers a clearer picture of who could be at risk in the future.
Fontana said. Ajayi T, Comer L, Kuntz L, et al. Turmeric-induced liver injury: a rare case of DILI. Poster presented at: American College of Gastroenterology Annual Scientific Meeting; October; Charlotte, North Carolina. Afiniwala S, Khalid F, Mohan G, Vyas C. Turmeric-associated liver injury: the yellow in your food causing the yellow in your skin.
Chang P, Liu A. A superfood with a dark side: a case of severe liver injury due to turmeric. Ashraf B, Brown T, Saeed S, Saeed Z, Tambovtseva A.
Skin as yellow as turmeric: a case report on turmeric-induced liver injury. Garcia Lopez J, Kee T, Marwil Z. Too much turmeric? A case of drug-induced liver injury. Halegoua-DeMarzio D, Navarro V, Ahmad J, et al.
Liver injury associated with turmeric-a growing problem: ten cases from the Drug-Induced Liver Injury Network [DILIN]. Am J Med. Food and Drug Administration. Curcumin from turmeric Curcuma longa L. National Center for Complementary and Integrative Health.
Smith T, Majid F, Eckl V, Morton Reynolds C. Herbal supplement sales in US increase by record-breaking Packaged turmeric-based beverages market by application and geography - forecast and analysis Vuppalanchi R, Bonkovsky HL, Ahmad J, et al.
Garcinia cambogiaeither alone or in combination with green tea, causes moderate to severe liver injury. Clin Gastroenterol Hepatol. Use limited data to select advertising. Create profiles for personalised advertising.
Use profiles to select personalised advertising. Create profiles to personalise content. Use profiles to select personalised content. Measure advertising performance. Measure content performance. Understand audiences through statistics or combinations of data from different sources. Develop and improve services.
Use limited data to select content. List of Partners vendors. By Healthwhere she covers breaking and trending news on health and wellness topics. Before joining HealthJulia held an internship position at Verywell Healthwhere she also covered news.
Her work has been featured in The Heightsan independent student newspaper at Boston College, and Minnesota Monthly. Julia Landwehr.
Julia is a news reporter for Healthwhere she covers breaking and trending news on health and wellness topics.
health's editorial guidelines. Fact checked by Nick Blackmer. Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years of experience in consumer-facing health and wellness content. health's fact checking process. Trending Videos.
Though turmeric is a common household spice and supplement, researchers are concerned that it may be linked to liver injury in some rare cases. Newer turmeric supplements are engineered to be more easily absorbed by the body, which could explain what appears to be an increase in negative reactions.
Experts hope with more awareness and reporting, we can get a clearer picture of the extent of the issue and figure out who might be at the greatest risk. What Is Turmeric? What Are the Effects of Daily Supplements on Your Health?
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: Curcumin and Liver Health| ‘A rare phenomenon’: Experts weigh in on DILIN data linking turmeric supplements to liver injury | This study was approved and funded by the Isfahan University of Medical Sciences, Isfahan, Iran with grant number Ziccardi P, et al. Lindenmeyer, C. Other remedies for fatty liver disease. Article CAS Google Scholar Tang Y. Nonalcoholic fatty liver disease NAFLD is one of the most common causes of chronic liver disease 1 , and its incidence is increasing across the world along with greater metabolic dysfunction, including hypertension, atherosclerosis, type 2 diabetes T2D , and obesity 2 , 3 , 4. The sample size was calculated according to the serum TNF-α. |
| Curcumin and liver injury risk correlation does not imply causation – CMA | Toxicol Ind Health. National Heart, Lung, and Blood Institute. Medications for fatty liver disease are currently in development. Trends Food Sci. Soleimani, V. Forest plots demonstrating the effect of curcumin on aspartate aminotransferase: all curcumin forms. Prevalence of and risk factors for fatty liver in the general population of northern Italy: the Bagnacavallo study. |
| The Trouble With Turmeric: Associated Liver Injuries | Jefferson Health | Jalali M, Mahmoodi M, Mosallanezhad Z, Jalali R, Imanieh MH, Moosavian SP. Very few studies have directly tested the safety of turmeric with other drugs. Recently, the relationship between MAFLD and metabolic syndrome have been suggested to be bidirectional 60 , 61 , Nakmareong S, Kukongviriyapan U, Pakdeechote P, Donpunha W, Kukongviriyapan V, Kongyingyoes B, et al. Rights and permissions Open Access This article is distributed under the terms of the Creative Commons Attribution 4. |
| ‘A rare phenomenon’: Experts weigh in on DILIN data linking turmeric supplements to liver injury | Halegoua-DeMarzio D, Navarro V, Ahmad J, et al. Liver injury associated with turmeric-a growing problem: ten cases from the Drug-Induced Liver Injury Network [DILIN]. Am J Med. Food and Drug Administration. Curcumin from turmeric Curcuma longa L. National Center for Complementary and Integrative Health. Smith T, Majid F, Eckl V, Morton Reynolds C. Herbal supplement sales in US increase by record-breaking Packaged turmeric-based beverages market by application and geography - forecast and analysis Vuppalanchi R, Bonkovsky HL, Ahmad J, et al. Garcinia cambogia , either alone or in combination with green tea, causes moderate to severe liver injury. Clin Gastroenterol Hepatol. Use limited data to select advertising. Create profiles for personalised advertising. Use profiles to select personalised advertising. Create profiles to personalise content. Use profiles to select personalised content. Measure advertising performance. Measure content performance. Understand audiences through statistics or combinations of data from different sources. Develop and improve services. Use limited data to select content. List of Partners vendors. By Health , where she covers breaking and trending news on health and wellness topics. Before joining Health , Julia held an internship position at Verywell Health , where she also covered news. Her work has been featured in The Heights , an independent student newspaper at Boston College, and Minnesota Monthly. Julia Landwehr. Julia is a news reporter for Health , where she covers breaking and trending news on health and wellness topics. health's editorial guidelines. Fact checked by Nick Blackmer. Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years of experience in consumer-facing health and wellness content. health's fact checking process. Trending Videos. Though turmeric is a common household spice and supplement, researchers are concerned that it may be linked to liver injury in some rare cases. Newer turmeric supplements are engineered to be more easily absorbed by the body, which could explain what appears to be an increase in negative reactions. Experts hope with more awareness and reporting, we can get a clearer picture of the extent of the issue and figure out who might be at the greatest risk. What Is Turmeric? What Are the Effects of Daily Supplements on Your Health? Was this page helpful? Thanks for your feedback! Tell us why! com uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Related Articles. Newsletter Sign Up. You may accept or manage your choices by clicking below, including your right to object where legitimate interest is used, or at any time in the privacy policy page. Independent sample t -tests or chi-squared tests were used to explore the bivariate differences at baseline and the end of the intervention. The changes in quantitative data were compared before and after the intervention using a paired sample t -test. The baseline characteristics of participants were compared between the groups by independent samples t -test or chi-squared test. One-way ANOVA tests were used to compare the groups in terms of quantitative variables. Out of 60 subjects, 56 completed the trial, and no patient experienced any adverse event. There were two dropouts in the curcumin group and two in the placebo group. All participants who dropped out did so due to personal reasons. Except for age, there was no significant difference in baseline characteristics including marital status, level of education, occupation, use of drugs affecting liver and blood lipids, sex, weight, BMI, WC, blood pressure BP, FBG, total cholesterol, TG, HDL-C, LDL-C, AST, ALT, fibrosis, and hepatic steatosis between the two groups at baseline Table 1. No significant differences were found in dietary intake and physical activity of the groups except for protein intake, omega-6, and selenium Table 2. Table 2. Nutritional intakes and physical activity and their changes in the treatment and control groups at baseline, after 6 weeks, and after 12 weeks. Even in some patients, the use of phytosomal curcumin, although it did not change the stage of steatosis, reduced the proportion of steatosis. Table 3. Comparison of anthropometry, biochemical parameters, and FibroScan factors before and after the study. NAFLD is one of the most common chronic liver disorders in the world 1. In this study, our findings are of great clinical importance because only one clinical trial evaluated the efficacy of curcumin on NAFLD by FibroScan This clinical trial showed that phytosomal curcumin had positive effects on fatty liver even at low doses. On the contrary, phytosomal curcumin consumption has important implications for managing NAFLD, which is a public health concern worldwide The present study showed that using phytosomal curcumin compared to placebo significantly improved fibrosis and steatosis symptoms in patients with NAFLD. In a study by Saadati et al. Despite its many properties, curcumin has low bioavailability due to low intestinal absorption and rapid metabolism The formulation of curcumin with phospholipids in the form of phytosomes increases the bioavailability of curcumin by improving intestinal absorption and metabolic stability 42 , which might explain the different findings of this study compared with the study by Saadati et al. To explain our findings regarding the beneficial effects of curcumin on fibrosis and steatosis, it should be mentioned that there is an association between oxidative stress, lipid peroxidation, and liver damage Insulin resistance is a major pathophysiological factor in metabolic syndrome, which is independently associated with fatty liver Therefore, curcumin can have beneficial effects on non-alcoholic fatty liver by controlling insulin resistance Conversely, curcumin inhibits NF-κB activation; reduces downstream induction of ICAM-1, COX-2, and MCP-1; and decreases intrahepatic gene expression of monocyte chemoattractant protein-1, of CD11b, of procollagen type I, and on the tissue inhibitor of metalloprotease-1, leading to the mitigation of the development and progression of hepatic inflammation and fibrosis In addition, curcumin enhances the activity of antioxidant enzymes, such as superoxide dismutase SOD and glutathione peroxidase GSH , by scavenging free radicals Thus, it appears that curcumin through the reduction of stress oxidative and inflammation plays a favorable role in liver diseases such as NAFLD. However, according to the study by Panahi et al. Conversely, according to the study by Mirhafez et al. The results of a systematic review study by Mansour—Ghanaei et al. Curcumin may improve hepatic steatosis and prevent the progression of fatty liver disease by inhibiting the synthesis of fatty acids and the biosynthesis of unsaturated fatty acids such as stearic acid, oleic acid, and linoleic acid Although liver enzymes are elevated in most patients with NAFLD, relying on liver enzymes to diagnose and monitor disease progression may be misleading and unreliable because they can fluctuate throughout the course of the disease. The patient may also be in the final stages of fatty liver cirrhosis , but the levels of these enzymes are normal In this study, in comparison to the placebo group, both fibrosis and steatosis were significantly reduced in the phytosomal curcumin receiving group, although it had no significant effects on the liver enzymes. These contradictory results suggest that more studies are needed to show the effects of phytosomal curcumin on liver status. These results may indicate that phytosomal curcumin is more effective with higher doses and longer duration of use. In the present study, the phytosomal curcumin receiving group resulted in a significant reduction in blood pressure compared to the placebo group. Hadi et al. Curcumin in high doses lowers blood pressure by inducing endothelial nitric oxide synthase eNOS protein expression and increasing antioxidant capacity through restoring glutathione GSH and a decrease in the overproduction of reactive oxygen species ROS 52 , Curcumin can improve the relaxation response of endothelial vessels to acetylcholine as well as increase the bioavailability of NO, and it also induces the expression of several antioxidant enzyme genes by the activation of the Nrf2-antioxidant response element signaling pathways 54 — In this study, supplementation with phytosomal curcumin resulted in a significant reduction in waist circumference compared with the placebo group, but it could not reduce weight and BMI. The results of a meta-analysis by Jafari Rad et al. The reason for this discrepancy may be the condition of the patients. In Mousavi et al. On the contrary, in Mousavi et al. Therefore, to better evaluate the effectiveness of curcumin on anthropometric indices, it is recommended to conduct more trials with longer intervention duration and different doses and types of curcumin. Nevertheless, it has been reported that curcumin can inhibit obesity by reducing the production of inflammatory compounds 59 , One possible mechanism of the impact of curcumin on anthropometric indices in cells and animals is accompanied by the suppression of peroxisome proliferator-activated receptor gamma and cytosine-cytosine-adenosine-adenosine-thymidine expressions 61 , Curcumin can also increase energy expenditure by increasing the production of adenosine triphosphate ATP and increasing AMP-activated protein kinase AMPK activity 63 — Curcumin can affect obesity through hormones. Moreover, curcumin can lower leptin and increase adiponectin levels, thereby modulating appetite and energy homeostasis Conversely, overproduction of the hormone adiponectin by activating AMPK can increase glucose utilization and oxidation of fatty acids, which facilitates weight loss 62 , In addition, because high levels of the stress hormone cortisol cause central obesity 68 , 69 , curcumin reduces the activating enzyme known as 11β-hydroxysteroid dehydrogenase type 1 11β-HSD1 68 , Curcumin can also cause weight loss by suppressing proinflammatory cytokines such as monocyte chemoattractant protein-1 MCP-1 , tumor necrosis factor-alpha TNF-α , and plasminogen activator inhibitor type-1 PAI-1 65 , Although it has been observed that curcumin has antidiabetic and lipid-modifying properties 26 , 46 , the results of this study showed that curcumin consumption did not lead to a significant reduction in profile lipids and FBG. The results of Mirhafez et al. The results of a meta-analysis of Jalali et al. Therefore, curcumin may have a better effect on FBG and lipid profile at higher doses, which explained the inconsistency in the results of our study with the recent meta-analysis In this study, the mean intake of selenium was significantly different between the study groups. We conducted further analyses to adjust its potential impact; however, the results remained unchanged data were not shown. Indeed, although the selenium intake was significantly different between the groups, the differences were minor. In addition, as mentioned above, patients who received antioxidant supplementation such as vitamin E and selenium were excluded from the study. Therefore, although it has been shown that selenium supplementation can effectively alleviate metabolic disorders such as NAFLD 72 , in our study, the difference in selenium intake did not account for the observed effects. Although this study was one of the first double-blind, randomized clinical trials to investigate the effect of phytosomal curcumin as a natural and available herbal medicine on NAFLD using FibroScan, some limitations of the study should be noted. The sample size was small, and future studies are needed to be performed with a larger sample size. Conversely, we used a single dose of phytosomal curcumin, which makes it difficult to draw conclusions concerning the dose-dependent effects of phytosomal curcumin on fatty liver. In addition, not all participants had elevated transaminase levels at baseline, precluding the possibility of a precise assessment of the effects of supplementation on liver enzymes and function. Finally, although the patients were randomized and classified based on gender and steatosis status, the mean age was significantly different between the study groups at baseline. However, all patients were categorized as adults, and no significant physiological and clinical differences could be observed between the two groups, which can affect the NAFLD status among them. This double-blind, placebo-controlled clinical trial indicated that the daily intake of mg phytosomal curcumin for 12 weeks could significantly improve liver fibrosis and steatosis and also reduce blood pressure and waist circumference. In addition, phytosomal curcumin could not significantly reduce fasting blood sugar, lipid profile, liver enzymes, and some anthropometric indices. Further studies are warranted to confirm these findings and to discover the underlying mechanisms. The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. The studies involving human participants were reviewed and approved by the IR. All authors designed the study, involved in the data collection, analysis, drafting of the manuscript, read, and approved the final manuscript. This study was approved and funded by the Isfahan University of Medical Sciences, Isfahan, Iran with grant number The authors would like to thank the valuable assistance of all participants. The authors are grateful for the support provided by the Indena S. A, Milan, Italy. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. NAFLD, non-alcoholic fatty liver disease; FBG, fasting blood sugar; ALT, alanine transaminase; AST, aspartate aminotransferase; TC, total cholesterol; TG, triglyceride; LDL, low-density lipoprotein; HDL, high-density lipoprotein; BMI, body mass index; WC, waist circumference; MET, metabolic equivalent; ATP, adenosine triphosphate; AMPK, adenosine monophosphate-activated protein kinase; ROS, reactive oxygen species; GSH, glutathione; SOD, superoxide dismutase; LSM, liver stiffness measurement; 11β-HSD1, 11β-hydroxysteroid dehydrogenase type1; TE, transient elastography; NF-κB, Nuclear Factor kappa-light-chain-enhancer of activated B cells; ICAM-1, intercellular adhesion molecule 1; COX-2, cyclooxygenase-2; MCP-1, monocyte chemoattractant protein-1; NO, nitric oxide; Nrf2, nuclear factor erythroid 2-related factor 2; eNOS, endothelial nitric oxide synthase. Ryoo J-H, Choi J-M, Moon SY, Suh YJ, Shin J-Y, Shin HC, et al. The clinical availability of non alcoholic fatty liver disease as an early predictor of the metabolic syndrome in Korean men: 5-year's prospective cohort study. doi: PubMed Abstract CrossRef Full Text Google Scholar. Mantovani A, Beatrice G, Stupia R, Dalbeni A. Prevalence and incidence of intra-and extrahepatic complications of NAFLD in patients with type 2 diabetes mellitus. Hepatoma Res. CrossRef Full Text Google Scholar. Wei Y, Wang S, Meng Y, Yu Q, Wang Q, Xu H, et al. Effects of vitamin d supplementation in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis. Hudert CA, Tzschätzsch H, Rudolph B, Loddenkemper C, Holzhütter H-G, Kalveram L, et al. How histopathologic changes in pediatric nonalcoholic fatty liver disease influence in vivo liver stiffness. Acta Biomater. Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Flisiak-Jackiewicz M, Lebensztejn DM. Update on pathogenesis, diagnostics and therapy of nonalcoholic fatty liver disease in children. Boursier J, Vergniol J, Guillet A, Hiriart J-B, Lannes A, Le Bail B, et al. Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease. J Hepatol. Hernandez-Rodas MC, Valenzuela R, Videla LA. Relevant aspects of nutritional and dietary interventions in non-alcoholic fatty liver disease. Int J Mol Sci. Taliento AE, Dallio M, Federico A, Prati D, Valenti L. Novel insights into the genetic landscape of nonalcoholic fatty liver disease. Int J Environ Res Public Health. Saeed N, Nadeau B, Shannon C, Tincopa M. Evaluation of dietary approaches for the treatment of non-alcoholic fatty liver disease: a systematic review. Liu ZL, Xie LZ, Zhu J, Li GQ, Grant SJ, Liu JP. Herbal medicines for fatty liver diseases. Cochrane Datab. Abrahams S, Haylett WL, Johnson G, Carr JA, Bardien S. Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: a review. da Silva AC, de Freitas Santos PD. do Prado Silva JT, Leimann FV, Bracht L, Goncalves OH. Impact of curcumin nanoformulation on its antimicrobial activity. Trends Food Sci. Song L, Zhang F, Yu J, Wei C, Han Q, Meng X. Antifungal effect and possible mechanism of curcumin mediated photodynamic technology against Penicillium expansum. Postharvest Biol Technol. Mathew D, Hsu W-L. Antiviral potential of curcumin. J Funct Foods. Farhood B, Mortezaee K, Goradel NH, Khanlarkhani N, Salehi E, Nashtaei MS, et al. Curcumin as an anti-inflammatory agent: implications to radiotherapy and chemotherapy. J Cell Physiol. Jahanbakhshi F, Dana PM, Badehnoosh B, Yousefi B, Mansournia MA, Jahanshahi M, et al. Curcumin anti-tumor effects on endometrial cancer with focus on its molecular targets. Cancer Cell Int. Mortezaee K, Salehi E, Mirtavoos-mahyari H, Motevaseli E, Najafi M, Farhood B, et al. Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy. Shakeri A, Cicero AFG, Panahi Y, Mohajeri M, Sahebkar A. Curcumin: a naturally occurring autophagy modulator. Afshari AR, Jalili-Nik M, Abbasinezhad-Moud F, Javid H, Karimi M, Mollazadeh H, et al. Anti-tumor effects of curcuminoids in glioblastoma multiforme: an updated literature review. Curr Med Chem. Mohajeri M, Bianconi V, Ávila-Rodriguez MF, Barreto GE, Jamialahmadi T, Pirro M, et al. Curcumin: a phytochemical modulator of estrogens and androgens in tumors of the reproductive system. Pharmacol Res. Nasri H, Abedi-Gheshlaghi Z, Rafieian-Kopaei M. Curcumin and kidney protection; current findings and new concepts. Acta Persica Pathophysiologica. Google Scholar. Pakzad B, Hedayat A, Ahmadian M, Bagheri GA, Akbari M. The effect of curcumin pill in treatment of non-alcoholic fatty liver disease: a clinical trial study. J Med Schl. Um MY, Hwang KH, Ahn J, Ha TY. Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase. Basic Clin Pharmacol Toxicol. Megahed MA-G, Fayed HM, Shamseya MM, Hassan SM, Shaaban MM. Am J Biomed Sci. Jalali M, Mahmoodi M, Mosallanezhad Z, Jalali R, Imanieh MH, Moosavian SP. The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. Chi C, Zhang C, Liu Y, Nie H, Zhou J, Ding Y. Phytosome-nanosuspensions for silybin-phospholipid complex with increased bioavailability and hepatoprotection efficacy. Lu M, Qiu Q, Luo X, Liu X, Sun J, Wang C, et al. Phyto-phospholipid complexes phytosomes : a novel strategy to improve the bioavailability of active constituents. Asian J. Hao H, Jia Y, Han R. Phytosomes: an effective approach to enhance the oral bioavailability of active constituents extracted from plants. J Chin Pharm Sci. Cicero AF, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr. Matthews DR, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Antolin GS, Pajares FG, Vallecillo M, Orcajo PF, de la Cuesta SG, Sagrado MG, et al. FibroScan Evaluation of Liver Fibrosis in Liver Transplantation. Transplantation Proceedings. Amsterdam: Elsevier Nguyen-Khac E, Chatelain D, Tramier B, Decrombecque C, Robert B, JOLY JP, et al. Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests. Aliment Pharmacol Ther. Wong GL-H. Update of liver fibrosis and steatosis with transient elastography Fibroscan. Gastroenterol Rep. de Lédinghen V, Vergniol J, Gonzalez C, Foucher J, Maury E, Chemineau L, et al. Screening for liver fibrosis by using FibroScan ® and FibroTest in patients with diabetes. Digestive Liver Disease. Tuong TTK, Tran DK, Phu PQT, Hong TND, Dinh TC, Chu DT. Non-alcoholic fatty liver disease in patients with type 2 diabetes: evaluation of hepatic fibrosis and steatosis using fibroscan. Oeda S, Tanaka K, Oshima A, Matsumoto Y, Sueoka E, Takahashi H. Diagnostic accuracy of fibroscan and factors affecting measurements. Lombardi R, Airaghi L, Targher G, Serviddio G, Maffi G, Mantovani A, et al. |
Curcumin and Liver Health -
According to Dr. But as soon as she restarted her turmeric regimen, the jaundice and hepatitis reappeared. Fontana, who was an author on the clinical research study. In the clinical research study, three of the seven turmeric products obtained from those with liver injuries also contained piperine, or black pepper.
This could also increase the likelihood of liver injury, researchers said. Marwil said, referencing the addition of piperine to turmeric supplements. Fontana mused. Though the new research highlights that liver injury due to turmeric supplementation appears to be increasing in the US, experts maintain say more research is needed before any sweeping recommendations on supplement use are made.
But we don't want to scare people, that this is going to lead to a recall and this kind of thing. Because the incidence here is still pretty low.
Symptoms such as abdominal pain, nausea, and jaundice are common with drug-induced liver injury, and have the potential to be associated with turmeric supplements, even if a person has been taking them for a while at the recommended dosage.
People with a history of liver disease, or with a history of drug or supplement sensitivity should avoid turmeric supplements just to be on the safe side, said Dr.
Fontana also explained that he hopes to spread the word so that people who may experience negative side effects from taking turmeric or their physicians can report the case to the Drug-Induced Liver Injury Network , and in turn, hopefully give researchers a clearer picture of who could be at risk in the future.
Fontana said. Ajayi T, Comer L, Kuntz L, et al. Turmeric-induced liver injury: a rare case of DILI. Poster presented at: American College of Gastroenterology Annual Scientific Meeting; October , ; Charlotte, North Carolina. Afiniwala S, Khalid F, Mohan G, Vyas C.
Turmeric-associated liver injury: the yellow in your food causing the yellow in your skin. Chang P, Liu A. A superfood with a dark side: a case of severe liver injury due to turmeric. Ashraf B, Brown T, Saeed S, Saeed Z, Tambovtseva A.
Skin as yellow as turmeric: a case report on turmeric-induced liver injury. Garcia Lopez J, Kee T, Marwil Z. Too much turmeric? A case of drug-induced liver injury.
Halegoua-DeMarzio D, Navarro V, Ahmad J, et al. Liver injury associated with turmeric-a growing problem: ten cases from the Drug-Induced Liver Injury Network [DILIN]. Am J Med. Food and Drug Administration. Curcumin from turmeric Curcuma longa L. National Center for Complementary and Integrative Health.
Smith T, Majid F, Eckl V, Morton Reynolds C. Herbal supplement sales in US increase by record-breaking Packaged turmeric-based beverages market by application and geography - forecast and analysis Vuppalanchi R, Bonkovsky HL, Ahmad J, et al.
Garcinia cambogia , either alone or in combination with green tea, causes moderate to severe liver injury. Clin Gastroenterol Hepatol. Use limited data to select advertising.
Create profiles for personalised advertising. Use profiles to select personalised advertising. Create profiles to personalise content.
Use profiles to select personalised content. Measure advertising performance. Measure content performance. Understand audiences through statistics or combinations of data from different sources. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.
Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. NAFLD, non-alcoholic fatty liver disease; FBG, fasting blood sugar; ALT, alanine transaminase; AST, aspartate aminotransferase; TC, total cholesterol; TG, triglyceride; LDL, low-density lipoprotein; HDL, high-density lipoprotein; BMI, body mass index; WC, waist circumference; MET, metabolic equivalent; ATP, adenosine triphosphate; AMPK, adenosine monophosphate-activated protein kinase; ROS, reactive oxygen species; GSH, glutathione; SOD, superoxide dismutase; LSM, liver stiffness measurement; 11β-HSD1, 11β-hydroxysteroid dehydrogenase type1; TE, transient elastography; NF-κB, Nuclear Factor kappa-light-chain-enhancer of activated B cells; ICAM-1, intercellular adhesion molecule 1; COX-2, cyclooxygenase-2; MCP-1, monocyte chemoattractant protein-1; NO, nitric oxide; Nrf2, nuclear factor erythroid 2-related factor 2; eNOS, endothelial nitric oxide synthase.
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Vollkommen
Ganz richtig! Ich denke, dass es die gute Idee ist.
Wie die Variante, ja
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