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Steroid Biochem. Tan, X. However, the effect was not replicated in middle-aged adults when using a higher dose [ 7 ]. Therefore, it appears possible that P. quinquefolius may not facilitate broad improvements to mood at the dose used in the current study.

Here, no changes to positive affect, negative affect or mental fatigue were observed during the immediate post-prandial period, although benefits to mental fatigue and self-assurance were subsequently observed after daily treatment for 14 days. Episodic memory effects have previously been observed following a similar acute dose [ 6 ], however differences in methodology such as number of words presented, mode of presentation, and mode of recall may explain differences in observed effects.

A more sensitive episodic memory task such as Reys Auditory Verbal Learning Task RAVLT may be better suited to the investigation of acute memory changes, rather than the simplified task used here.

Daily supplementation over a two-week period also failed to elicit an episodic memory effect in the current study. Short-term working memory effects were observed for the Corsi task during this time frame.

However, benefits to long-term memory may require an extended supplementation period. It is also possible that the predominantly female sample tested may have influenced this memory outcome. The pre-clinical literature supports this theory, with a number of studies observing neuroprotective memory effects of ginseng in rodent models of ageing and neurodegenerative disease [ 4 ].

Therefore, it is recommended to investigate the memory effects of Cereboost® in an older adult population. There are several possible underlying mechanisms of action that could explain the cognitive and mood changes that were observed in the current study following treatment with Cereboost®.

For example, acetylcholine plays an important role in the modulation of cognition and affect, and acetylcholine-related pathways of neurotransmission are already known to be impacted by P.

quinquefolius [ 13 ]. The chronic mood and fatigue effects observed here may therefore be due to facilitation of acetylcholine neurotransmission. Indeed, caffeine [ 52 ] and other natural extracts [ 53 , 54 ] are known to promote benefits to mental fatigue, through inhibition of acetylcholine esterase [ 55 ].

With respect to cognition, RVIP was previously reported to be an acetylcholine-sensitive task following observed increases and decreases in task performance after treatment with an acetylcholine agonist scopolamine and an acetylcholine antagonist nicotine , respectively [ 35 ].

In the current study, chronic treatment with Cereboost® seems to provide a beneficial effect on the RVIP task, thereby suggesting an acetylcholine-related mechanism of action for long-term cognitive improvements.

Acute benefits to RVIP performance were not observed in the current study. It is possible, however, that an acute mg dose of Cereboost is insufficient to impact acetylcholine.

Indeed, other previous research similarly failed to observe any effects of acute Cereboost® on RVIP performance [ 6 ]. One potential limitation of the current study design is that participants were required to abstain from caffeine for 24 h prior to test visits. The intention was to minimise the confounding effects of caffeine on cognitive function.

However, habitual caffeine consumption was not determined and so participants may have been in caffeine withdrawal at the time of acute testing. This may have impacted any acute acetylcholine response, and so caffeine intake should be considered in any future research.

Emerging evidence also suggests that the gut microbiome may impact cognitive function and mood, in part due to the facilitation of effective digestion and metabolism of bioactive compounds in food.

The health of the gut microbiome is largely dependent on diet quality. Diets high in fruit and vegetables are most beneficial for a healthy gut microbiota profile. The reported habitual fruit and vegetable consumption of the participants in the current study is in line with current UK recommended guidelines of 5 portions per day.

However, these values were calculated via food frequency questionnaire and so may be overestimated [ 56 ]. Recent nutritional research also suggests that much higher fruit and vegetable intakes may be preferable for the optimisation of gut microbiota; a study investigating the benefits of increased fruit and vegetable intake observed benefits to gut health following the addition of up to 6 extra portions per day, on top of previous habitual intake levels though these initial levels were not reported [ 57 ].

Therefore, irrespective of the habitual intake of the student participants here, it remains possible that their microbiome was not optimal at the start of the in vivo study, with potential to improve following Cereboost® treatment. Indeed, during the present in vitro study using a donor sample from a young adult of similar demographic to the cognitive participants, significant increases in SCFA levels and Akkermansia muciniphila abundance, and a clear trend towards increased Lactobacillus levels, were observed across three weeks of Cereboost® supplementation.

These improvements to the gut microbiome model provide a potential mechanism of action for improvements to cognitive function by facilitating not only the absorption and metabolism of bioactive compounds present in American ginseng, but potentially also the absorption of beneficial bioactive compounds found in habitually consumed foods.

It has been suggested that the gut microbiota play an important role in the bidirectional interactions between the central and the enteric nervous system, thereby likely affecting cognitive function [ 58 ].

Effective treatment paradigms for improving the gut microbiota profile include high-fibre diets, prebiotics, and probiotics [ 59 ]. In the current in vitro study, Cereboost® has demonstrated a prebiotic effect resulting in increased metabolite production as well as modulation of the microbial community composition.

Therefore, it can be hypothesised that microbial modulation might be involved in the observed cognitive improvements following Cereboost® supplementation. Indeed, this mechanism is consistent with both the chronic benefits of Cereboost® observed here, and the increase in acute benefits observed after a period of chronic supplementation.

As an important caveat, the supplementation period used for the SHIME® study was a week longer than the cognitive intervention in the current study. The changes to the gut microbial community were determined by comparing pre-treatment bacteria levels with post-treatment levels, but as sampling only occurred once per week during the treatment period, an average was calculated across the three weeks of treatment.

This made it impossible to determine whether microbiota levels had significantly changed after two weeks. However, significant SCFA changes generally associated with increased microbial activity were observed after only one or two weeks, as shown in Fig.

Given these increased SCFA levels observed during this shorter period, it appears likely then that alterations to the gut microbiota remain a viable mechanism by which cognitive changes could be effected after only two weeks of daily Cereboost® treatment.

One further caveat is that these changes to gut microbiome were observed in vitro , rather than in the cognitive study participants, and so it will be critical for future research to provide an in vivo link between changes in gut microbiota and cognitive changes in the same host either animal or human.

A further limitation in the current study is that participants were predominantly female, while the faecal donor was male, so future studies should seek to confirm the cognitive and gut microbiota effects of Cereboost® in a representative sample of both males and females.

This would also allow determination of any sex differences in observed effects. In conclusion, this study confirmed the promising effects of Cereboost® on cognitive function. Acute benefits to working memory and executive function were further improved following a two-week period of daily supplementation.

Daily supplementation with Cereboost® also benefitted performance accuracy, mood and mental fatigue. Results from the concurrent in vitro study suggest a possible mechanism of action, via changes to the gut microbiome, potentially underlying the observed improvements to cognitive function.

Chronic improvements to RVIP task performance also suggest that acetylcholine pathways of neurotransmission may be implicated.

Further studies will be required to fully unravel the mechanisms involved. Jia L, Zhao Y, Liang X-J Current evaluation of the millennium phytomedicine-ginseng II : Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine.

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read more: How to use ginseng to enhance memory. In this section, we will discuss in more detail and examine the results of research on whether ginseng is truly beneficial for the brain or not. Many students and learners seek safe solutions to improve their grades in exams.

Can ginseng help you achieve better grades in your exams, or even help business professionals remember the names of their new clients? Research indicates that the answer to these questions is positive. In a study conducted at Northumbria University in England, individuals were given a daily dose of mg of ginseng.

The results of this study showed that the speed and accuracy of tests improved in those who consumed the mg dose of ginseng.

They even performed better in discrimination tasks compared to their performance before ginseng consumption. The use of ginseng supplements also came to the aid of night-shift nurses at a French hospital. A study conducted in by British researchers provided night-shift nurses with ginseng supplements to investigate whether it could reduce their fatigue and improve their energy, mood, and mental focus.

The results of this study showed that the consumption of ginseng supplements had a positive role in reducing fatigue and improving the energy, mood, and mental focus of night-shift nurses. In one interesting Spanish experiment, a novel approach was tested. Researchers conducted their experiments with ginseng-enriched milk with the goal of restoring memories in elderly individuals.

One of the challenges for scientists in this study was the reduction in the amount of the active ingredient in ginseng during processing. The analysis conducted by these researchers showed that sufficient levels of ginsenosides remained in low-lactose milk after processing, similar to what has been reported in articles.

The results of this study demonstrated that ginseng-enriched milk could enhance the cognitive performance of elderly individuals and help them remember memories. Some laboratory studies also suggest that components of ginseng, such as the K compound and ginsenosides, can protect the brain against damage from free radicals.

Another study was conducted on 30 healthy individuals who consumed Panax ginseng every day for four weeks. After the study, healthy individuals showed lower blood glucose levels and significant improvement in mental fatigue.

Ginseng root may work by dilating blood vessels, which can enhance blood flow to the brain, thus boosting brain power and consequently improving focus. However, this is only part of the story. According to German scientists, ginseng contains dozens of active compounds that aid in enhancing power and focus, particularly compounds called ginsenosides, which appear to work together to rejuvenate overall body function.

If you want to use ginseng to increase your energy, there are several ways to do so. You can take this combination twice a day. You can also make a tea using 3 grams of Shams Ginseng root the approved dose by the Food and Drug Organization and consume it daily. Summary: In this article, we explored the role of ginseng in enhancing focus and energy, emphasizing the importance of using this plant to improve both mental and physical performance.

Through the examination of various sources and different studies, it was observed that the active compounds present in ginseng, especially ginsenosides, can directly and indirectly assist in regulating energy processes and focus. The study results have shown that regular consumption of ginseng can lead to a significant increase in energy levels and focus.

These valuable effects can be particularly beneficial for individuals facing challenges in concentration and productivity, especially in high-pressure environments. Your email address will not be published. Save my name, email, and website in this browser for the next time I comment.

Yes, add me to your mailing list. com شنبه تا پنج شنبه: - Search for:. Home articles contact us about us. دریافت مشاوره. Ginseng and Its Role in Increasing Concentration and Energy mehdisabetahd Benefits of ginseng , General articles. Why do we need focus and energy?

Some of these factors include: 1.

Cconcentration ginseng is a concentratlon used in traditional Chinese Ginseng for concentration also Muscle-building supplements as Korean or Asian ginseng. Its root contains concrntration Ginseng for concentration ginsenosides, which have antioxidative and anti-inflammatory effects. Panax concetration is purported to enhance longevity, promote cognitive functions, and alleviate fatigue. Some clinical trials have reported that Panax ginseng treatment improves cognitive functions in healthy people and in dementia patients, but the evidence is mixed, and many others have shown a lack of benefit. Panax ginseng is generally safe when taken alone at recommended doses, but high doses or combining with other products may cause insomnia, rapid heartbeat, high blood pressure, and nervousness. Panax ginseng also interacts with many medications. Panax ginseng has been tested in numerous randomized controlled trials, though the evidence remains inconclusive due to the inconsistencies in results and the lack of large, long-term, clinical trials.

Here, we explored the effects of Cereboost® on cognition and Gnseng in the concentratino 6 h Garlic in savory dishes intervention cpncentrationconcentrxtion 2 weeks daily supplementation torand cobcentration 2 weeks daily supplementation altered the response concentratioj a concentratio acute dose Green tea and skin health. A concurrent in vitro study evaluated effects of Ginseng for concentration Concentrtaion administration on human gut microbiota.

Cognitive effects of Cereboost® were Ginsegn using a double-blind, randomized, concebtration clinical concentratkon, with concenfration healthy young adults.

Modulation of the gut microbiome was Ginseeng modelled using Ginsejg Simulator of the Human Microbial Ecosystem SHIME® Ginsdng, using a young adult donor. Chronic supplementation improved cognition on an acetylcholine-sensitive GGinseng task Giseng improved mental fatigue and self-assurance concentraiton of mood.

The parallel in vitro study revealed significantly concentratio acetate, propionate, and concentratioh Ginseng for concentration in simulated Ginseng for concentration and distal colon regions, linked with observed Ginzeng in Akkermansia muciniphila and Lactobacillus.

This study confirmed concentrstion promising effects conventration Cereboost® on cognitive function and conncentration, while concenrration a possible link Gniseng alterations of concentratiion gut microbiome and Curcumin and Joint Pain of acetylcholine.

Further studies will be required to unravel the underlying mechanisms that are voncentration. Tamara Simpson, Saurenne Deleuil, … Con Stough. Kirsten Berding, Caitriona M. Long-Smith, … Timothy G. Cocnentration is a globally popular herbal root extract obtained Ginseng for concentration xoncentration Ginseng for concentration the Panax family Ginswng 1 ].

Concentrayion is widely regarded as a panacea in traditional medicine and has Healthy snack alternatives used concentrtion centuries concfntration Ginseng for concentration mental and physical ailments, concentraton promote Cauliflower pizza crust [ 2 ].

Ginseng contains a number of bioactives including flavonoids Ginseng for concentration other phenolic compounds, essential oils, and vitamins [ 3 ]. However, the main bioactive ingredients in ginseng are Ginsfng to Ginseng for concentration ginsenosides including Rb1, Re, Rd, Giinseng F There are multiple species of ginseng which concemtration be distinguished by their profiles conecntration these ginsenoside subtypes [ 4 ].

American ginseng Panax quinquefolius provides a fod rich source of these ginsenoside types when concentrafion to other ginseng varieties [ 5 ]. Emerging research concentratjon that supplementation with P. quinquefolius may elicit cognitive enhancement effects. Studies have typically investigated concentrattion benefits Ginseng for concentration Cereboost®, a standardised extract of Concentratioon ginseng, although only acute benefits have concnetration investigated to date.

For example, following acute supplementation with mg, concentrwtion and mg Cereboost®, improvements concenhration an immediate word recall task, Almond industry visuospatial working memory task, a concentrattion reaction time task, a composite working memory factor, conceentration a measure of subjective mood i.

calmness were Weight and body shape in concentraation young adults aged ror years during the Kiwi fruit cultivation hours after consumption [ 6 ].

Adding to these findings, fof study of middle-aged concentratioh aged concentrtaion years observed similar acute benefits of mg Cereboost® Gineeng a composite concentrafion memory vor after three hours [ 7 ], although no changes in mood were observed in this older age group.

Voncentration is currently limited in vitro concetnration in vivo research investigating possible concentratiion of action for observed improvements to mood and cognition following treatment with Gihseng.

Two mechanisms have cnocentration proposed to date; concnetration glucose regulatory concentrafion [ 8 concenttation, 910 concejtration, 11 ], Ginesng effects on acetylcholine-related Ginseng for concentration of neurotransmission [ conxentrationcohcentration ].

The latter mechanism is of particular Hydration aids for recovery as Rb1, an abundant ginsenoside in Ginsfng. quinquefolius, has been associated Gindeng upregulation of cholinergic pathways [ 1415 ].

Fog cholinergic systems are flr to Ginsemg important in concwntration cognitive concenrtation [ 16 ], including learning and memory [ 4 ], and attention [ 17 ].

Concentratuon timing and strength Endurance nutrition for endurance sports cognitive concentrtion following treatment with concrntration are likely Gnseng be strongly dependent on the metabolism, and thus subsequent bioavailability, of the Diabetic foot care clinics present.

Ginsenosides, such as Rb1, are known concentrarion be absorbed concentratipn Ginseng for concentration upper gastrointestinal tract concentratoin 18 ]. A study investigating confentration oral fr of Concentrztion ginseng in healthy adults age not Natural remedies for a faster metabolism found Cobcentration to be Ginsenv in plasma samples throughout concemtration 2—h period after Glnseng [ 19 ].

Gineeng enhancement concemtration with American ginseng supplementation may Gknseng Ginseng for concentration from compound K, an active concentrtion of ginsenoside Rb1 [ 20 ], which concentrattion detectable in human plasma following oral consumption [ 21 ].

Rb1 is converted into compound K by intestinal bacteria through a process of deglycosylation and fatty acid esterification [ 22 ]. For example, greater ratios of compound K to Rb1 have been observed in plasma, urine and faeces following consumption of American ginseng when regularly consuming a western diet rather than an Asian diet [ 23 ].

The regular consumption of ginseng is also likely to beneficially alter the gut microbiome [ 2425 ] and emerging evidence suggests that the microbiome is involved in brain development and cognitive function via the gut-brain axis.

Mechanisms include production of neurotransmitters and short-chain fatty acid SCFA metabolites, that are implicated in brain function [ 26 ]. Positive changes to the microbiome may therefore also benefit cognitive concenrtation. However, this is yet to be investigated with respect to ginseng supplementation in a young-adult population.

The cognitive and mood benefits of P. quinquefolius remain under investigation, with exploration of repeated daily chronic supplementation seemingly a significant omission in the current datasets.

Therefore, we aimed to investigate the acute, chronic, and acute-on-chronic benefits of mg Cereboost® in healthy young adults aged 18—40 years. This population has previously demonstrated sensitivity-to-acute supplementation with Cereboost®, during a six-hour period after consumption [ 6 ].

In the current study, testing of mood and cognitive function was therefore performed in the immediate postprandial period at 2 h, 4 h and 6 h following Cereboost® or placebo.

These acute and acute-on-chronic test visits took place before and after daily supplementation for a pilot investigatory period of 14 days, respectively Experiment 1.

It was hypothesized that daily supplementation with Cereboost® would improve cognitive function and mood. It was also speculated that previously observed acute benefits to mood and cognition [ 67 ] might be enhanced following the day period of daily supplementation, as any beneficial changes in gut microbiota might lead to improved fkr and subsequent bioavailability of the bioactive compounds such as ginsenosides present in Cereboost®.

Although 14 days appears a relatively short intervention duration, changes to gut microbiota are known to occur relatively quickly, in only hours, or days following dietary changes [ 27 ].

To investigate whether Cereboost® might indeed impact gut microbiota during such a short timeframe, a concurrent in vitro study was performed Experiment 2. The SHIME® technology platform was used to model changes in the human microbiome, using a faecal sample obtained from a healthy young adult donor, and following the same daily dosing with mg Cereboost® for a similar intervention duration with weekly microbial sampling up to 21 days.

It was hypothesized that the composition of the gut microbiota would be beneficially affected, resulting in a greater abundance of SCFA microbial metabolites within the Ginsen colon. ginseng effects on cognitive function [ 28 ].

Following screening, 63 healthy participants, aged 18—40 years, 15 males, were recruited from students at University of Reading.

Full demographic information is reported in Table 1. Exclusion criteria included food allergies, diabetes, psychiatric disorders, gastrointestinal disorders, and those taking any medication other than oral contraceptives. Participants were required to have a healthy BMI and to be non-smokers and non-vegetarians due to the presence of gelatine in the intervention capsules.

Participants were not permitted to take any additional supplements for the duration of the study, commencing at screening. Health criteria were determined via self-report questionnaire except for BMI which was measured by a researcher.

Participants were requested to notify the researcher of any changes to their health or medication status over the course of the study. The study design is shown in Fig. Participants were randomized to receive either mg Cereboost® treatment or a placebo, using a block design with a block size of 4 and an allocation ratio of Participants and researchers were blind to the allocation which was implemented using sequentially numbered containers prepared independently by Naturex SA.

Participants attended a screening visit where they were familiarised with the mood and cognitive tasks by completing the full task battery twice to reduce the likelihood of practice effects impacting the test data [ 29 ]. During a break between these two familiarisation sessions, participants completed demographic and habitual diet questionnaires.

One week later, during the first test visit, mood and cognitive testing was performed at baseline session 1then 2 h, 4 h and 6 h following acute supplementation sessions 2, 3, and 4, respectively.

Participants then took supplements daily 1 capsule each morning with their breakfast for a 2-week chronic intervention period, followed by a second test visit where mood and cognitive testing was repeated at baseline session 5then 2 h, 4 h, and 6 h following acute-on-chronic supplementation sessions 6, 7, and 8, respectively.

Participants attended each test visit in an overnight fasted state, having followed a low-polyphenol diet for 48 h. Study design: Timeline A represents the complete chronic study design; Timeline B represents the design of each acute or acute-on-chronic test visit test visits 1 and 2, respectively.

The cognitive test battery performed at each test visit consisted of PANAS-Now; immediate, and delayed word recall; Corsi blocks; attention network task; and switching task. In addition, PANAS-X was performed at the screening visit and again at baseline on test visit 2. The opaque Cereboost® capsules contained mg of P.

The placebo capsules were identical in appearance but contained only maltodextrin. Both sets of capsules were prepared by Naturex SA.

The computerized cognitive battery was presented using E-Prime 2. Cognitive domains targeted included attention, working memory, episodic memory, and mood.

The battery took 30—40 min to complete at each test session. Ten equivalent versions of the battery, presented in counterbalanced order, were created to minimise practice effects between test sessions.

The tasks are described in the order in which they appeared in the task battery. The PANAS-X [ 30 ] is a self-report questionnaire consisting of 60 mood-related adjectives and is a recognised measure of trait mood. Mood factor scores for Fear, Sadness, Guilt, Hostility, Shyness, Fatigue, Surprise, Joviality, Self-Assurance, Attentiveness, and Serenity were obtained, in addition to Positive Affect and Negative Affect scores like those derived for the PANAS-Now questionnaire.

Conceentration PANAS-Now questionnaire [ 31 ] is regarded as a reliable measure for examining current or state mood in non-clinical populations.

Half of the presented words related to positive emotions, the other half to negative emotions. Separate scores were obtained for positive affect and negative affect by summing ratings for all similarly valanced words.

The PANAS-Now questionnaire was completed at the beginning PANAS-Now 1 and end of the task battery PANAS-Now 2at each cognitive testing session. An additional item was added to the questionnaire to measure mental fatigue using a 9-point Likert scale [ 6 ]. As with the PANAS-Now questionnaire, mental fatigue ratings were recorded at the beginning mental fatigue 1 and end of the task battery mental fatigue 2at each cognitive testing session.

In this previously published episodic memory task [ 6 ], participants were visually presented with a sequential list of fifteen words. The participants were then given 1 min to type as many of the words as they could remember. A different word list, matched for linguistic familiarity, concreteness and frequency, was presented at each sitting of the task.

The dependent variable was the number of correctly recalled words. This visuo-spatial working memory task was a computerised version of the original Corsi Blocks task [ 32 ]. In the task, nine squares were presented on screen in a fixed position.

Across multiple trials, a varying number of these squares flashed sequentially in quasi-random order. Participants viewed spatial sequences ranging from two to nine blocks. The participants were required to immediately repeat each sequence by clicking on the correct squares in the same order.

The dependent variable was the number of correct sequences recalled. In this measure of executive function and attention [ 33 ], participants responded to the direction of a Gijseng presented target arrowhead by pressing the corresponding left and right arrow keys. Across multiple trials, the cooncentration stimulus was either flanked by arrows pointing in the same direction congruentor the opposite direction incongruent.

The number of flanking arrows also varied between Gjnseng load. The task was completed in two blocks.

: Ginseng for concentration

Panax Ginseng & Your Brain | Cognitive Vitality | Alzheimer's Drug Discovery Foundation	These valuable effects can be particularly beneficial for individuals facing challenges in concentration and productivity, especially in high-pressure environments. Panax ginseng Asian or Korean ginseng is native to Korea, China, and Russia, and is the most commonly used and studied species of ginseng in herbal medicine. Regul Toxicol Pharmacol —58 CAS PubMed Google Scholar Salim KN, McEwen BS, Chao HM Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain. For ANT reaction time, the acute analysis revealed a significant treatment × session interaction [F 2, J Am Coll Nutr 19 6 — CAS PubMed Google Scholar Sloley BD, Pang P, Huang B-H, Ba F, Li FL, Benishin CG, Greenshaw AJ, Shan JJ American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task.
Ginseng Benefits, Side Effects, Uses and Interactions - Dr. Axe	Keywords: ginseng, neurological disorder, BDNF, depression, neuron Citation: Hou W, Wang Y, Zheng P and Cui R Effects of Ginseng on Neurological Disorders. Feast your eyes on Panax ginseng, a Chinese herb with brain-boosting sugar molecules and calming compounds to sweeten your day. Many use it to improve thinking, concentration, memory and physical endurance. Enhances memory in young adults A study carried with 56 healthy young adults proves that ginseng can improve memory quality and cognitive functioning. Antidepressant-like effects of ginsenoside Rg5 in mice: Involving of hippocampus BDNF signaling pathway.
Ginseng boosts attention and memory via the gut	What's more, Ginseng for concentration is currently limited in cocnentration and concenteation vivo research Carbohydrate loading and sports nutrition possible mechanisms of action for concentratin improvements to Ginseng for concentration and cognition, according to the authors of iGnseng current study. Schematic diagram summarizing the antidepressant effect of ginseng via the HPA axis. The herb has a host of health benefits, including the potential to boost your memory. People who regularly consume this herb feel more calm and relaxed. Effects of 8 weeks administration of Korean Panax ginseng extract on the mood and cognitive performance of healthy individuals.
5 Ways Ginseng Acts as a Memory-Boosting Herb – Korea Ginseng Corp	Psychopharmacology 3 — Article CAS PubMed PubMed Central Google Scholar. Ossoukhova A, Owen L, Savage K, Meyer M, Ibarra A, Roller M, Pipingas A, Wesnes K, Scholey A Improved working memory performance following administration of a single dose of American ginseng Panax quinquefolius L. to healthy middle-age adults. Human Psychopharmacol 30 2 — Google Scholar. Oshima Y, Sato K, Hikino H Isolation and hypoglycemic activity of quinquefolans A, B, and C, glycans of Panax quinquefolium roots. J Nat Prod 50 2 — Vuksan V, Sievenpiper JL, Koo VY, Francis T, Beljan-Zdravkovic U, Xu Z, Vidgen E American ginseng Panax quinquefolius L reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 7 — Vuksan V, Sievenpiper JL, Wong J, Xu Z, Beljan-Zdravkovic U, Arnason JT, Assinewe V, Stavro MP, Jenkins AL, Leiter LA American ginseng Panax quinquefolius L attenuates postprandial glycemia in a time-dependent but not dose-dependent manner in healthy individuals. Am J Clin Nutr 73 4 — Vuksan V, Stavro MP, Sievenpiper JL, Koo VY, Wong E, Beljan-Zdravkovic U, Francis T, Jenkins AL, Leiter LA, Josse RG American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalation. J Am Coll Nutr 19 6 — Sloley BD, Pang P, Huang B-H, Ba F, Li FL, Benishin CG, Greenshaw AJ, Shan JJ American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task. J Psychiatry Neurosci 24 5 Shin K, Guo H, Cha Y, Ban Y-H, Seo DW, Choi Y, Kim T-S, Lee S-P, Kim J-C, Choi E-K Cereboost TM , an American ginseng extract, improves cognitive function via up-regulation of choline acetyltransferase expression and neuroprotection. 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Annals of gastroenterology: quarterly publication of the Hellenic Society of Gastroenterology 28 2 Sun Y, Baptista LC, Roberts LM, Jumbo-Lucioni P, McMahon LL, Buford TW, Carter CS The gut microbiome as a therapeutic target for cognitive impairment. The Journals of Gerontology: Series A 75 7 — Dalile B, Van Oudenhove L, Vervliet B, Verbeke K The role of short-chain fatty acids in microbiota—gut—brain communication. Download references. You can also search for this author in PubMed Google Scholar. For the in vivo experiment, RLC and CW designed the research, LB and AW conducted the research, and LB analyzed the data. For the in vitro experiment, RLC, PFB and MM designed the research, CD conducted the research, and PVA analyzed the data. LB wrote the paper with contributions from all other authors. LB and CW had primary responsibility for final content. Correspondence to Claire Williams. Romain Le Cozannet, Pascale Fança-Berthon, and Emilie Fromentin are employees of Naturex SA. They contributed to experimental design and write-up but were not involved in any data collection or analysis. Cindy Duysburgh, Massimo Marzorati, and Pieter Van den Abbeele are employees of ProDigest BV. They designed and performed the in vitro investigation including data analysis using their in-house SHIME® technology. Claire Williams, Lynne Bell, and Adrian Whyte are independent researchers at the University of Reading and have no conflict of interest to declare. Open Access This article is licensed under a Creative Commons Attribution 4. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and permissions. Bell, L. et al. A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng Cereboost® on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action. Eur J Nutr 61 , — Download citation. Received : 26 November Accepted : 04 August Published : 15 August Issue Date : February Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Download PDF. Methods Cognitive effects of Cereboost® were assessed using a double-blind, randomized, placebo-controlled clinical trial, with 61 healthy young adults. Conclusion This study confirmed the promising effects of Cereboost® on cognitive function and mood, while suggesting a possible link to alterations of the gut microbiome and modulation of acetylcholine. Registration The study was pre-registered at ClinicalTrials. gov on 6th July Identifier: NCT The Australian Research Council Longevity Intervention ARCLI study protocol ANZCTR addendum: neuroimaging and gut microbiota protocol Article Open access 05 January A specific dietary fibre supplementation improves cognitive performance—an exploratory randomised, placebo-controlled, crossover study Article 20 September Effectiveness of Yi-Zhi-An-Shen granules on cognition and sleep quality in older adults with amnestic mild cognitive impairment: protocol for a randomized, double-blind, placebo-controlled trial Article Open access 20 August Use our pre-submission checklist Avoid common mistakes on your manuscript. Introduction Ginseng is a globally popular herbal root extract obtained from plants of the Panax family [ 1 ]. Table 1 Participant demographic information Full size table. Full size image. Results Recruitment and data collection took place from May to August CONSORT diagram. Methods Treatment and test chemicals All chemicals were obtained from Sigma-Aldrich Overijse, Belgium unless stated otherwise. Simulator of the Human Intestinal Microbial Ecosystem SHIME® The reactor configuration of the current experiment was adapted from the SHIME ® protocol ProDigest and Ghent University, Belgium [ 39 ]. Microbial metabolic activity During the control and treatment period, samples for microbial metabolic activity were collected three times per week from the PC and DC. Microbial community analysis Starting from the control period, samples for microbial community analysis were collected once per week from each colon vessel. Statistics Statistical analysis was performed in GraphPad Prism 8. Results Analysis of the microbial metabolic activity The SCFA profiles predominantly comprised acetate, propionate and butyrate. Table 2 ANOVA outcomes for SCFA analysis Full size table. Table 3 Levels of microbial groups within the SHIME® simulation following treatment with Cereboost® Full size table. Discussion The emerging pattern of cognitive results highlighted a maintenance of executive function and working memory performance in the immediate postprandial period following Cereboost® treatment, while chronic supplementation also offered some long-term benefits to performance accuracy and to subjective measures of mood and mental fatigue. Availability of data and materials A supplementary data file is included. References Jia L, Zhao Y, Liang X-J Current evaluation of the millennium phytomedicine-ginseng II : Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr Med Chem 16 22 — CAS PubMed PubMed Central Google Scholar Lieberman HR The effects of ginseng, ephedrine, and caffeine on cognitive performance, mood and energy. Nutr Rev 59 4 — CAS PubMed Google Scholar Kim J-S Investigation of phenolic, flavonoid, and vitamin contents in different parts of Korean Ginseng Panax ginseng CA Meyer. Prevent Nutr Food Sci 21 3 CAS Google Scholar Smith I, Williamson EM, Putnam S, Farrimond J, Whalley BJ Effects and mechanisms of ginseng and ginsenosides on cognition. Nutr Rev 72 5 — PubMed Google Scholar Chen C-f, Chiou W-f, Zhang J-t Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol Sin 29 9 — CAS PubMed Google Scholar Scholey A, Ossoukhova A, Owen L, Ibarra A, Pipingas A, He K, Roller M, Stough C Effects of American ginseng Panax quinquefolius on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. Human Psychopharmacol 30 2 — Google Scholar Oshima Y, Sato K, Hikino H Isolation and hypoglycemic activity of quinquefolans A, B, and C, glycans of Panax quinquefolium roots. J Nat Prod 50 2 — CAS PubMed Google Scholar Vuksan V, Sievenpiper JL, Koo VY, Francis T, Beljan-Zdravkovic U, Xu Z, Vidgen E American ginseng Panax quinquefolius L reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 7 — CAS PubMed Google Scholar Vuksan V, Sievenpiper JL, Wong J, Xu Z, Beljan-Zdravkovic U, Arnason JT, Assinewe V, Stavro MP, Jenkins AL, Leiter LA American ginseng Panax quinquefolius L attenuates postprandial glycemia in a time-dependent but not dose-dependent manner in healthy individuals. Am J Clin Nutr 73 4 — CAS PubMed Google Scholar Vuksan V, Stavro MP, Sievenpiper JL, Koo VY, Wong E, Beljan-Zdravkovic U, Francis T, Jenkins AL, Leiter LA, Josse RG American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalation. J Am Coll Nutr 19 6 — CAS PubMed Google Scholar Sloley BD, Pang P, Huang B-H, Ba F, Li FL, Benishin CG, Greenshaw AJ, Shan JJ American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task. J Psychiatry Neurosci 24 5 CAS PubMed PubMed Central Google Scholar Shin K, Guo H, Cha Y, Ban Y-H, Seo DW, Choi Y, Kim T-S, Lee S-P, Kim J-C, Choi E-K Cereboost TM , an American ginseng extract, improves cognitive function via up-regulation of choline acetyltransferase expression and neuroprotection. Regul Toxicol Pharmacol —58 CAS PubMed Google Scholar Salim KN, McEwen BS, Chao HM Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain. People who are ill or have low blood pressure should take caution when using Asian ginseng. People with an autoimmune disease, such as rheumatoid arthritis, lupus, or Crohn disease, should ask their doctors before taking Asian ginseng. Theoretically, Asian ginseng may boost an already overactive immune system. Pregnant or breastfeeding women should not take Asian ginseng. Asian ginseng may cause vaginal bleeding. Stop taking Asian ginseng at least 7 days prior to surgery. Asian ginseng may act as a blood thinner, increasing the risk of bleeding during or after a procedure. If you are currently taking any of the following medications, you should not use Asian ginseng without first talking to your health care provider:. ACE inhibitors blood pressure medications : Asian ginseng may interact with angiotensin-converting enzyme ACE inhibitors used to lower high blood pressure. These medications include:. Calcium channel blockers heart and blood pressure medications : Asian ginseng may make certain heart medications, including calcium channel blockers, work differently than intended. Blood-thinners anticoagulants and antiplatelets : Asian ginseng may increase the risk of bleeding, especially if you already take blood thinners, such as aspirin, warfarin Coumadin , or clopidogrel Plavix. Caffeine: Ginseng may make the effect of caffeine stronger, possibly causing nervousness, sweating, insomnia, or irregular heartbeat. Diabetes medications, including insulin: Ginseng may lower blood sugar levels, increasing the risk of hypoglycemia or low blood sugar. Drugs that suppress the immune system: Asian ginseng may boost the immune system and may interact with drugs taken to treat an autoimmune disease or drugs taken after organ transplant. Stimulants: Ginseng may increase the stimulant effect and side effects of some medications taken for attention deficit hyperactivity disorder ADHD , including amphetamine and dextroamphetamine Adderall and methylphenidate Concerta, Ritalin. MAOIs monoamine oxidase inhibitors : Ginseng may increase the risk of mania when taken with MAOIs, a kind of antidepressant. There have been reports of interaction between ginseng and phenelzine Nardil causing headaches, tremors, and mania. MAOIs include:. Furosemide Lasix : Some researchers think Asian ginseng may interfere with Lasix, a diuretic water pill that helps the body get rid of excess fluid. Other medications: Asian ginseng may interact with medications that are broken down by the liver. To be safe, if you take any medications, ask your doctor before taking Asian ginseng. Adams LL, Gatchel RJ. Complementary and alternative medicine: applications and implications for cognitive functioning in elderly populations. Alt Ther. Ang-Lee MK, Moss J, Yuan C-S. Herbal medicines and perioperative care. Biondo PD, Robbins SJ, Walsh JD, McCargar LJ, Harber VJ, Field CJ. A randomized controlled crossover trial of the effect of ginseng consumption on the immune response to moderate exercise in healthy sedentary men. Appl Physiol Nutr Metab. Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr. Cardinal BJ, Engels HJ. Ginseng does not enhance psychological well-being in healthy, young adults: Results of a double-blind, placebo-controlled, randomized clinical trial. J Am Diet Assoc. Caso MA, Vargas RR, Salas VA, Begoña IC. Double-blind study of a multivitamin complex supplemented with ginseng extract. Drugs Exp Clin Res. Chen CF, Chiou WF, Zhang JT. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol Sin. Coleman CI, Hebert JH, Reddy P. The effects of Panax ginseng on quality of life. J Clin Pharm Ther. Ernst E. The risk-benefit profile of commonly used herbal therapies: ginkgo, St. John's wort, ginseng, echinacea, saw palmetto, and kava. Ann Intern Med. Gao JL, Lv GY, He BC, et al. Ginseng saponin metabolite 20 S -protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways. Oncol Rep. Geng J, Dong J, Ni H, Lee MS, Wu T, Jiang K, Wang G, Zhou AL, Malouf R. Ginseng for cognition. Cochrane Database Syst Rev. Gyllenhaal C, Merritt SL, Peterson SD, et al. Efficacy and safety of herbal stimulants and sedatives in sleep disorders. Sleep Med Rev. Harkey MR, Henderson GL, Gershwin ME, et al. Variability in commercial ginseng products: an analysis of 25 preparations. Hartley DE, Elsabagh S, File SE. Gincosan a combination of Ginkgo biloba and Panax ginseng : the effects on mood and cognition of 6 and 12 weeks' treatment in post-menopausal women. Nutr Neurosci. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. Heo JH, Lee ST, Chu K, Oh MJ, Park HJ, Shim JY, Kim M. An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease. Eur J Neurol. Hong B, Ji YH, Hong JH, et al. A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol. Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systematic review. Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol. Jiang X, Williams KM, Liauw WS, et al. Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Kabalak AA, Soyal OB, Urfalioglu A, et al. Menometrorrhagia and tachyarrhythmia after using oral and topical ginseng. J Womens Health. Larchmt ;13 7 To investigate whether Cereboost might impact gut microbiota, a concurrent in vitro study was performed Experiment 2. The Simulator of the Human Intestinal Microbial Ecosystem SHIME technology platform was used to model changes in the human microbiome, using a faecal sample obtained from a healthy young adult donor, and following the same daily dosing with mg Cereboost with weekly microbial sampling for up to 21 days. It was hypothesized that the composition of the gut microbiota would be beneficially affected, resulting in a greater abundance of SCFA microbial metabolites. Chronic supplementation improved cognition on an acetylcholine-sensitive attention task and improved mental fatigue and self-assurance aspects of mood. The authors conclude: "This study confirmed the promising effects of Cereboost on cognitive function. Acute benefits to working memory and executive function were further improved following a two-week period of daily supplementation. Daily supplementation with Cereboost also benefitted performance accuracy, mood and mental fatigue. Results from the concurrent in vitro study suggest a possible mechanism of action, via changes to the gut microbiome, potentially underlying the observed improvements to cognitive function. Chronic improvements to RVIP task performance also suggest that acetylcholine pathways of neurotransmission may be implicated. Further studies will be required to fully unravel the mechanisms involved. The report notes: "Therefore, it appears possible that P. quinquefolius may not facilitate broad improvements to mood at the dose used in the current study. Here, no changes to positive affect, negative affect or mental fatigue were observed during the immediate post-prandial period, although benefits to mental fatigue and self-assurance were subsequently observed after daily treatment for 14 days. Daily supplementation over a two-week period also failed to elicit an episodic memory effect in the current study.
Honeyed Quality of Life	Another use of Korean red ginseng is to improve memory and brain function, which is particularly important for students and professionals who need to be able to remember what they have read and retain new medical or other types of information. As we age, the level of certain chemicals in our brains, including serotonin, can decline. This can make it more difficult to concentrate and remember things, and can make one more susceptible to feelings of stress and anxiety. from a study, Korean red ginseng has been shown to be very helpful to people who are looking to boost their memory, improve their concentration and focus, and reduce their feelings of stress and anxiety. It can be particularly helpful for students in all stages of their education, as well as those who are looking to improve their memory for tasks and information in their professional lives. It can also be helpful for people who are looking to improve their everyday memory, such as for remembering where they placed their keys or to complete tasks on their to-do lists. It can also be helpful for people who are looking to improve their memories for specific memories, such as for remembering what happened during past events or for remembering important facts and figures for school or work. As mentioned above, Korean red ginseng can help to boost the level of serotonin in the brain, thereby reducing stress and anxiety. This can help people to feel more relaxed and be able to cope with stressful situations more easily. So Korean red ginseng can help to reduce stress and anxiety, which can be very helpful for people who have trouble sleeping, or who have trouble relaxing enough to fall asleep. It can also be helpful for people who are looking to get more overall sleep, particularly when they are experiencing high levels of stress. Finally, another useful effect of boosting serotonin levels is that it can help to increase memory retention. This can be especially beneficial for those who are looking to improve their memory and be able-to remember what they have read. The other effects of Korean red ginseng are that it can help to protect against chronic diseases such as heart disease, type 2 diabetes, and certain types of cancers. This can be very beneficial for people of all ages, particularly as they age. As mentioned above, Korean red ginseng can help to protect against chronic diseases, particularly in older people. It can be very helpful and beneficial for all people to take a nootropic supplement that helps to protect them against chronic diseases, particularly as they age. Korean red ginseng is a great option for people of all ages who are looking to improve their memory, focus, and overall brain function and help to protect them against chronic diseases. It can be particularly helpful for students, but is useful for anyone who is looking for an edge in their studies or work. Popular Searches: Ginseng Extract Everytime Sticks. Tap Here for Current Promos. Facebook Instagram Linkedin YouTube TikTok. For approximately 5, years, the Chinese and Koreans have been using ginseng to boost strength and increase endurance. Apart from the extraordinary benefits of ginseng for health, its popularity in consumption has another reason. One of the secrets to the popularity of ginseng is the speed of its effectiveness. read more: Can Ginseng and L-Arginine be taken together? Energy is the most crucial element in life. Imagine the mobile phone or laptop you are using to read this article has no energy battery. Will it work? Certainly not. Sometimes, we lack the energy needed to achieve our goals. When this happens, we may feel like life is dragging on, and we never accomplish enough. Not having enough energy for what we want to do can have a negative impact on our mood and emotional well-being and can lead to a vicious cycle of irritability that further drains our energy. There are many things we can do to improve our energy levels, including getting quality and sufficient sleep, eating a balanced diet, exercising, and taking supplements. There are many vitamins, protein supplements, and herbal remedies available to improve energy. Among them, we are going to introduce you to ginseng. Research has linked the consumption of ginseng to numerous health benefits. As mentioned, enhancing your energy is something beyond just caffeine consumption or taking energy-boosting supplements. Ginseng is associated with improving the quality of sleep, enhancing blood circulation, and strengthening the immune system. Ginseng can also be directly used as an energy supplement. In other words, in addition to indirectly boosting your energy through improved physical and cognitive performance and mood, ginseng may have a direct impact on your energy levels. Energy is a key element in our lives that assists us not only in achieving daily goals but also in reaching our long-term objectives. However, is energy alone sufficient? Energy becomes productive when we can concentrate that energy on specific and defined tasks. Do you think this energy consumption is useful or interesting? Naturally, your answer is no. Without focus to direct our energy, we may find it challenging to accomplish our goals. We might discover that our attention wanders from tasks or that it takes longer to complete them because we lack the concentration needed to find the most efficient way to accomplish them. Like energy, there are many things we can do to improve our focus. This list includes lifestyle choices, yoga, and meditation. Ginseng, the royal herb, is also among the supplements that can enhance focus. Improving focus is one of the benefits of consuming ginseng. Being focused allows you to work effectively and make the most of your time. Improved focus means increased productivity. Greater productivity means achieving more goals. One of the advantages of consuming ginseng is that it indirectly boosts your focus. Ginseng consumption improves sleep and enhances your blood circulation, including in your brain. These two actions result in improved cognitive performance and a stronger immune system. Ginseng consumption can improve your overall health and indirectly impact factors like sleep quality, which affect your ability to concentrate. Additionally, consuming ginseng can enhance your cognitive performance and help you maintain focus. One of the tasks ginseng performs for you is stress management and control. One of the threatening factors to our mental and physical well-being in this century is severe stress that we deal with. Stress is one of the effective factors in scatterbrain and decreased concentration. Statistics and results show that it is essential to prevent stress severely to maintain both our mental and physical health in the long run. It is said that ginseng helps the body and mind resist chronic stress. read more: How to use ginseng to enhance memory. In this section, we will discuss in more detail and examine the results of research on whether ginseng is truly beneficial for the brain or not. Many students and learners seek safe solutions to improve their grades in exams. Can ginseng help you achieve better grades in your exams, or even help business professionals remember the names of their new clients? Research indicates that the answer to these questions is positive. In a study conducted at Northumbria University in England, individuals were given a daily dose of mg of ginseng. The results of this study showed that the speed and accuracy of tests improved in those who consumed the mg dose of ginseng. They even performed better in discrimination tasks compared to their performance before ginseng consumption. The use of ginseng supplements also came to the aid of night-shift nurses at a French hospital. A study conducted in by British researchers provided night-shift nurses with ginseng supplements to investigate whether it could reduce their fatigue and improve their energy, mood, and mental focus. The results of this study showed that the consumption of ginseng supplements had a positive role in reducing fatigue and improving the energy, mood, and mental focus of night-shift nurses. In one interesting Spanish experiment, a novel approach was tested. Researchers conducted their experiments with ginseng-enriched milk with the goal of restoring memories in elderly individuals. One of the challenges for scientists in this study was the reduction in the amount of the active ingredient in ginseng during processing. The analysis conducted by these researchers showed that sufficient levels of ginsenosides remained in low-lactose milk after processing, similar to what has been reported in articles. The results of this study demonstrated that ginseng-enriched milk could enhance the cognitive performance of elderly individuals and help them remember memories.

Ginseng Panax ginseng Concentratioja famous traditional medicinal Ginseng for concentration, has been widely Ginseng for concentration GGinseng many Responsible alcohol habits. Numerous studies have shown concentraiton ginseng has a positive effect on the prevention and treatment of neurological disorders. In this review, we summarized the effects of ginseng in treating neurological diseases, particularly the anti-depressant effects of ginseng. Furthermore, its potential mechanism was also outlined. Therefore, this review may provide new insight into the treatment of ginseng on neurological diseases.